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Post exposure hiv prophylaxis

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https://www.readbyqxmd.com/read/29909589/-it-was-not-my-aim-to-sleep-there-the-impact-of-timing-and-location-of-sex-on-adherence-to-coitally-dependent-hiv-pre-exposure-prophylaxis
#1
Fiona Scorgie, Jonathan Stadler, Deborah Baron, Susan Ju, Tshepiso Ikaneng, Zonke Mabude, Sylvia Makgopa, Matshidiso A Malefo, Kgahlisho N Manenzhe, Thulani Mazibuko, Hilda Ntjana, Busi Nkala, Thesla Palanee-Phillips, Glenda Gray, Helen Rees, Sinead Delany-Moretlwe
The FACTS 001 trial found that vaginal pre- and post-coital application of 1% tenofovir gel did not prevent HIV-1 infection amongst young South African women. The trial included a multi-faceted approach to adherence support and collected objective and self-reported adherence measures. Using qualitative data collected from a random sub-set of FACTS 001 participants (135 in-depth interviews at product discontinuation and 13 focus group discussions at dissemination of trial results), we explore the importance of 'place' and 'timing' in shaping acts of sexual intimacy and product adherence...
June 16, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29902179/hybrid-stochastic-framework-predicts-efficacy-of-prophylaxis-against-hiv-an-example-with-different-dolutegravir-prophylaxis-schemes
#2
Sulav Duwal, Laura Dickinson, Saye Khoo, Max von Kleist
To achieve the 90-90-90 goals set by UNAIDS, the number of new HIV infections needs to decrease to approximately 500,000 by 2020. One of the 'five pillars' to achieve this goal is pre-exposure prophylaxis (PrEP). Truvada (emtricitabine-tenofovir) is currently the only medication approved for PrEP. Despite its advantages, Truvada is costly and requires individuals to adhere to the once-daily regimen. To improve PrEP, many next-generation regimen, including long-acting formulations, are currently investigated...
June 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29868545/hiv-prevention-after-discontinuing-pre-exposure-prophylaxis-conclusions-from-a-case-study
#3
Kai J Jonas, Natthakhet Yaemim
Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate in combination with emtricitabine (FTC) is a highly effective form of HIV prevention. Endeavors of health-care providers and activists in many countries over the world are directed at making access to PrEP possible, or increasing PrEP use among men-who-have-sex-with-men (MSM). We argue while this effort is necessary, we also need to consider modes of HIV prevention after a period of PrEP use. PrEP uptake is not a one-way street, meaning that individuals may discontinue PrEP use, either voluntarily and involuntarily...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29858737/post-exposure-prophylaxis-awareness-knowledge-access-and-use-among-three-populations-in-new-york-city-2016-17
#4
Beryl A Koblin, DaShawn Usher, Vijay Nandi, Hong-Van Tieu, Eddie Bravo, Debbie Lucy, London Miles, Geneva Ortiz, Marcia J Kindlon, Donna M Parisi, Victoria Frye
Post-exposure prophylaxis (PEP) is a cost-effective, but underused HIV prevention strategy. PEP awareness, knowledge, access, and usage was assessed among young men of color who have sex with men (YMSMOC; n = 177), transgender women (TW; n = 182), and cisgender women of color (CWOC; n = 170) in New York City. 59% were aware of PEP: 80% among YMSMOC, 63% among TW and 34% among CWOC (p < 0.001). 13% had ever used PEP. PEP awareness was higher among YMSMOC with a recent HIV test and lower among those with ≥ 4 partners...
June 1, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29852062/targeted-hiv-testing-at-birth-supported-by-low-and-predictable-mother-to-child-transmission-risk-in-botswana
#5
Maryanne Ibrahim, Kenneth Maswabi, Gbolahan Ajibola, Sikhulile Moyo, Michael D Hughes, Oganne Batlang, Maureen Sakoi, Chloe Auletta-Young, Laura Vaughan, Shahin Lockman, Patrick Jean-Philippe, Xu Yu, Matthias Lichterfeld, Daniel R Kuritzkes, Joseph Makhema, Roger L Shapiro
INTRODUCTION: Most African countries perform infant HIV testing at 6 weeks or later. The addition of targeted testing at birth may improve retention in care, treatment outcomes and survival for HIV-infected infants. METHODS: HIV-exposed infants were screened as part of the Early Infant Treatment (EIT) study in Botswana. Screened infants were ≥35 weeks gestational age and ≥2000 g at birth. Risk factors for mother-to-child transmission (MTCT) were assessed by maternal obstetric card or verbally...
May 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29845871/differences-in-awareness-of-and-willingness-to-use-pre-exposure-prophylaxis-and-anticipated-condom-use-among-serodiscordant-couples-in-taiwan
#6
Nai-Ying Ko, Huei-Jiuan Wu, Carol Strong, Chia-Wen Li, Wen-Wei Ku, Su-Ting Hsu
Pre-exposure prophylaxis (PrEP) has proven to be effective in reducing the risk of HIV transmission in uninfected individuals who engaged in sexual activity with HIV-infected partners. Serodiscordant couples are the key targets of PrEP implementation. The study aimed to compare awareness of and willingness to use PrEP and anticipated condom use among 112 HIV-serodiscordant couples: 32 heterosexuals couples, 70 men who have sex with men (MSM) couples, and 10 people who inject drugs (PWID) couples. A cross-sectional study was conducted in an AIDS designated hospital in Taiwan...
May 30, 2018: AIDS Care
https://www.readbyqxmd.com/read/29793873/executive-summary-of-the-gesida-consensus-document-on-control-and-monitoring-of-hiv-infected-patients
#7
(no author information available yet)
The continuous increase in our knowledge of HIV medicine and antiretroviral treatment has led us to draft specific consensus documents focused on topics other than antiretroviral therapy, such as treatment of opportunistic diseases, pre- and post-exposure prophylaxis, metabolic abnormalities, treatment of HBV or HCV coinfection, treatment of patients coinfected with tuberculosis, osteoporosis, kidney disorders, and cardiovascular risk. Accordingly, the AIDS Study Group (GeSIDA) of the Spanish Society of Infectious Diseases and Clinical Microbiology has promoted the drafting of this consensus document on the control and monitoring of adult patients infected with HIV...
May 21, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29791514/high-prevalence-of-syndemic-health-problems-in-patients-seeking-post-exposure-prophylaxis-for-sexual-exposures-to-hiv
#8
Steven A Morrison, Deborah Yoong, Trevor A Hart, Paul MacPherson, Isaac Bogoch, Vishalini Sivarajah, Kevin Gough, Mark Naccarato, Darrell H S Tan
INTRODUCTION: The standard clinical approach to non-occupational HIV post-exposure prophylaxis (nPEP) focuses on biomedical aspects of the intervention, but may overlook co-occurring or 'syndemic' psychosocial problems that reinforce future vulnerability to HIV. We therefore sought to determine the prevalence of syndemic health problems in a cohort of Ontario nPEP patients, and explored the relationship between syndemic burden and HIV risk. METHODS: Between 07/2013-08/2016, we distributed a self-administered questionnaire to patients presenting to three clinics in Toronto and Ottawa seeking nPEP for sexual HIV exposures...
2018: PloS One
https://www.readbyqxmd.com/read/29790254/chemsex-and-new-hiv-diagnosis-in-gay-bisexual-and-other-men-who-have-sex-with-men-attending-sexual-health-clinics
#9
M Pakianathan, W Whittaker, M J Lee, J Avery, S Green, B Nathan, A Hegazi
OBJECTIVES: The aim of the study was to analyse associations between chemsex and new HIV and sexually transmitted infection (STI) diagnoses among gay, bisexual and other men who have sex with men (GBMSM) accessing sexual health clinics. METHODS: A retrospective case note review was carried out for all GBMSM attending two London sexual health clinics between 1 June 2014 and 31 July 2015. RESULTS: Chemsex status was documented for 1734 of 1840 patients...
May 22, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29777425/the-use-of-hiv-post-exposure-prophylaxis-in-forensic-medicine-following-incidents-of-sexual-violence-in-hamburg-germany-a-retrospective-study
#10
Julia Ebert, Jan Peter Sperhake, Olaf Degen, Ann Sophie Schröder
In Hamburg, Germany, the initiation of HIV post-exposure prophylaxis (HIV PEP) in cases of sexual violence is often carried out by forensic medical specialists (FMS) using the city's unique Hamburg Model. FMS-provided three-day HIV PEP starter packs include a combination of raltegravir and emtricitabine/tenofovir. This study aimed to investigate the practice of offering HIV PEP, reasons for discontinuing treatment, patient compliance, and whether or not potential perpetrators were tested for HIV. We conducted a retrospective study of forensic clinical examinations carried out by the Hamburg Department of Legal Medicine following incidents of sexual violence from 2009 to 2016...
May 18, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29770060/setting-the-stage-for-expanding-hiv-pre-exposure-prophylaxis-use-in-canada
#11
EDITORIAL
M Hull, Dhs Tan
Human immunodeficiency virus (HIV) infection continues to disproportionately affect vulnerable populations in Canada; particularly men who have sex with men (MSM). Novel HIV prevention strategies have recently expanded from the use of non-occupational post-exposure prophylaxis (nPEP) after high risk exposures to the use of pre-exposure prophylaxis (PrEP) in which individuals reduce risk of HIV infection through use of combination antiretrovirals taken prior to risk exposure. With approval of tenofovir/emtricitabine (TDF/FTC) for use as PrEP only in early 2016, and with limited public funding to date, uptake in Canada is in its preliminary stages...
December 7, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29765441/suspected-unexpected-and-other-adverse-reactions-to-antiretroviral-drugs-used-as-post-exposure-prophylaxis-of-hiv-infection-five-year-experience-from-clinical-practice
#12
Justyna D Kowalska, Ewa Pietraszkiewicz, Ewa Firląg-Burkacka, Andrzej Horban
Introduction: With increased use of antiretroviral drugs (ARVs) in HIV uninfected persons, proper reporting on suspected unexpected serious adverse reactions (SUSARs) and continued insight into adverse drug reactions (ADRs) are needed for adequate information on safety of ARVs in such populations. Material and methods: Medical documentation of persons receiving ARVs after non-occupational HIV exposure (non-occupational post-exposure prophylaxis - nPEP) during 5 successive years (2009-2013) was evaluated by two HIV physicians...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29762169/change-in-sexual-risk-behaviour-after-six-months-of-pre-exposure-prophylaxis-use-results-from-the-amsterdam-prep-demonstration-project
#13
Elske Hoornenborg, Liza Coyer, Anna van Laarhoven, Roel Achterbergh, Henry de Vries, Maria Prins, Maarten Schim van der Loeff
OBJECTIVE: HIV pre-exposure prophylaxis (PrEP) use may lead to higher STI incidence via behavioral risk compensation. We examined changes in sexual behaviour between baseline and six months after PrEP initiation among men who have sex with men (MSM) and transgender women (TGW). DESIGN: Prospective, open-label demonstration study at a large sexually transmitted infections (STI) clinic in Amsterdam, the Netherlands. METHODS: Participants answered questions about sexual behaviour in the preceding three months, including number of anal sex partners and frequency of anal sex with and without condom by partner type and were tested for STI...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29700052/changes-in-recreational-drug-use-drug-use-associated-with-chemsex-and-hiv-related-behaviours-among-hiv-negative-men-who-have-sex-with-men-in-london-and-brighton-2013-2016
#14
Janey Sewell, Valentina Cambiano, Ada Miltz, Andrew Speakman, Fiona C Lampe, Andrew Phillips, David Stuart, Richard Gilson, David Asboe, Nneka Nwokolo, Amanda Clarke, Graham Hart, Alison Rodger
OBJECTIVES: The objective of this study was to compare the prevalence of polydrug use, use of drugs associated with chemsex, specific drug use, and HIV-related behaviours, between two time periods , using two groups of HIV-negative men who have sex with men (MSM) attending the same sexual health clinics in London and Brighton, in two consecutive periods of time from 2013 to 2016. METHODS: Data from MSM in the cross-sectional Attitudes to and Understanding Risk of Acquisition of HIV (AURAH) study (June 2013 to September 2014) were compared with baseline data from different MSM in the prospective cohort study Attitudes to and Understanding Risk of Acquisition of HIV over Time (AURAH2) (November 2014 to April 2016)...
April 26, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29687590/a-systematic-review-of-risk-of-hiv-transmission-through-biting-or-spitting-implications-for-policy
#15
F V Cresswell, J Ellis, J Hartley, C A Sabin, C Orkin, D R Churchill
OBJECTIVES: The perceived threat of HIV transmission through spitting and biting is evidenced by the increasing use of "spit hoods" by Police Forces in the UK. In addition, a draft parliamentary bill has called for increased penalties for assaults on emergency workers, citing the risk of communicable disease transmission as one justification. We aimed to review literature relating to the risk of HIV transmission through biting or spitting. METHODS: A systematic literature search was conducted using Medline, Embase and Northern Lights databases and conference websites using search terms relating to HIV, AIDS, bite, spit and saliva...
April 23, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29684327/do-health-promotion-messages-integrate-unintended-pregnancy-and-sti-prevention-a-content-analysis-of-online-information-for-adolescents-and-young-adults
#16
Riley J Steiner, Catherine N Rasberry, Jessica M Sales, Laura M Gaydos, Karen Pazol, Michael R Kramer, Andrea Swartzendruber
OBJECTIVE: Recently there have been calls to strengthen integration of unintended pregnancy and sexually transmitted infection (STI) prevention messages, spurred by increasing use of long-acting reversible contraception. To assess the extent to which public health/clinical messages about unintended pregnancy prevention also address STI prevention, we conducted a content analysis of web-based health promotion information for young people. STUDY DESIGN: Websites identified through a systematic Google search were eligible for inclusion if they were operated by a United States-based organization with a mission related to public health/clinical services and the URL included: 1) original content; 2) about sexual and reproductive health; 3) explicitly for adolescents and/or young adults...
April 21, 2018: Contraception
https://www.readbyqxmd.com/read/29676342/audit-of-prevention-of-mother-to-child-transmission-programme-interventions-in-hiv-exposed-children-at-national-hospital-abuja-nigeria
#17
Mariya Mukhtar-Yola, Adekunle Tolulope Otuneye, Amsa Baba Mairami, Yewande Wey, Vincent Nwatah, Lamidi Isah Audu
Background: Ninety percentage of children acquire human immunodeficiency virus (HIV) infection in the form of Mother-to-child Transmission (MTCT). In the absence of interventions, transmission rates range from 15% to 45%. This can be reduced to below 5% with effective interventions. The last published national guideline (NG) on prevention of MTCT (PMTCT) was in 2010. Clinical audits are essential in improving the quality of care delivered to patients. Objectives: The study objectives were to determine the rate of MTCT of HIV in exposed infants at a follow-up clinic between 2011 and 2014 and to determine the level of adherence to 2010 NG on the use of highly active antiretroviral therapy (HAART), polymerase chain reaction (PCR) testing, feeding options, antiretroviral (ARV) prophylaxis and the use of co-trimoxazole (CTZ)...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29673698/-which-information-is-given-during-the-purchase-of-an-hiv-self-test-in-a-caen-pharmacy-a-comprehensive-transversal-and-observational-study-using-surveys-without-modification-of-practice
#18
S Guitton, A Rabiaza
INTRODUCTION: HIV infection affects about 150,000 people in France. In total, 30,000 of them are unaware of their serostatus. In this context, HIV self-testing has arrived in France in September 2015. The aim of our study was to analyze the level of application of the recommendations during the purchase of an HIV self-test. Our primary hypothesis was that the delivered information is poor. METHODS: We realized a comprehensive transversal and observational study with surveys without modification of practice in all Caen pharmacies...
April 16, 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29626043/hiv-1-disease-progression-in-immune-competent-hiv-1-infected-and-breastfeeding-mothers-participating-in-the-anrs-12174-clinical-trial-in-burkina-faso-south-africa-uganda-and-zambia-a-cohort-study
#19
Eric Nagaonle Somé, Ingunn M S Engebretsen, Nicolas Nagot, Nicolas Yelbomkan Meda, Roselyne Vallo, Chipepo Kankasa, James K Tumwine, Mandisa Singata-Madliki, Kim Harper, G Justus Hofmeyr, Philippe Van de Perre, Thorkild Tylleskär
OBJECTIVE: We have assessed HIV-1 disease progression among HIV-1-positive mothers in relation to duration of any or exclusive breast feeding in the context of ANRS 12174 trial. METHODS: The analysis was completed on 203, 212, 272 and 529 HIV-1-positive and lactating mothers with CD4 count >350 cells/µL from Burkina Faso, South Africa, Uganda and Zambia, respectively. The trial compared lamivudine and lopinavir/ritonavir as a peri-exposure prophylaxis during a 50-week follow-up time...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29625796/sexualised-drug-use-in-the-united-kingdom-uk-a-review-of-the-literature
#20
Claire Edmundson, Ellen Heinsbroek, Rachel Glass, Vivian Hope, Hamish Mohammed, Martin White, Monica Desai
BACKGROUND: Sexualised drug use (SDU) refers to the use of drugs in a sexual context. This includes 'Chemsex'- the use of drugs (specifically crystal methamphetamine, GHB/GBL and mephedrone) before or during planned sexual activity to sustain, enhance, disinhibit or facilitate the experience. Here we aimed to synthesise available UK prevalence data for Chemsex, SDU and the use of Chemsex drugs in an undefined context (CDU) in men who have sex with men (MSM). METHODS: Papers published between January 2007 and August 2017 reporting Chemsex, SDU and/or Chemsex drug use (CDU) prevalence in MSM were identified through PubMed...
May 2018: International Journal on Drug Policy
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