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https://www.readbyqxmd.com/read/28806758/developmental-vascular-remodeling-defects-and-postnatal-kidney-failure-in-mice-lacking-gpr116-adgrf5-and-eltd1-adgrl4
#1
Shun Lu, Shuya Liu, Astrid Wietelmann, Baktybek Kojonazarov, Ann Atzberger, Cong Tang, Ralph Theo Schermuly, Hermann-Josef Gröne, Stefan Offermanns
GPR116 (ADGRF5) and ELTD1 (ADGRL4) belong to different subfamilies of the adhesion G-protein-coupled receptor group but are both expressed in endothelial cells. We therefore analyzed their functions in mice lacking these receptors. While loss of GPR116 or ELTD1 alone had no obvious effect on cardiovascular or kidney function, mice lacking both, GPR116 and ELTD1, showed malformations of the aortic arch arteries and the cardiac outflow tract leading to perinatal lethality in about 50% of the mutants. In addition to cardiovascular malformations, surviving mice developed renal thrombotic microangiopathy as well as hemolysis and splenomegaly, and their lifespan was significantly reduced...
2017: PloS One
https://www.readbyqxmd.com/read/28803710/intrathecal-2-hydroxypropyl-%C3%AE-cyclodextrin-decreases-neurological-disease-progression-in-niemann-pick-disease-type-c1-a-non-randomised-open-label-phase-1-2-trial
#2
Daniel S Ory, Elizabeth A Ottinger, Nicole Yanjanin Farhat, Kelly A King, Xuntian Jiang, Lisa Weissfeld, Elizabeth Berry-Kravis, Cristin D Davidson, Simona Bianconi, Lee Ann Keener, Ravichandran Rao, Ariane Soldatos, Rohini Sidhu, Kimberly A Walters, Xin Xu, Audrey Thurm, Beth Solomon, William J Pavan, Bernardus N Machielse, Mark Kao, Steven A Silber, John C McKew, Carmen C Brewer, Charles H Vite, Steven U Walkley, Christopher P Austin, Forbes D Porter
BACKGROUND: Niemann-Pick disease, type C1 (NPC1) is a lysosomal storage disorder characterised by progressive neurodegeneration. In preclinical testing, 2-hydroxypropyl-β-cyclodextrins (HPβCD) significantly delayed cerebellar Purkinje cell loss, slowed progression of neurological manifestations, and increased lifespan in mouse and cat models of NPC1. The aim of this study was to assess the safety and efficacy of lumbar intrathecal HPβCD. METHODS: In this open-label, dose-escalation phase 1-2a study, we gave monthly intrathecal HPβCD to participants with NPC1 with neurological manifestation at the National Institutes of Health (NIH), Bethesda, MD, USA...
August 10, 2017: Lancet
https://www.readbyqxmd.com/read/28803147/ovarian-hormones-sleep-and-cognition-across-the-adult-female-lifespan-an-integrated-perspective
#3
REVIEW
Nicole J Gervais, Jessica A Mong, Agnès Lacreuse
Loss of ovarian function in women is associated with sleep disturbances and cognitive decline, which suggest a key role for estrogens and/or progestins in modulating these symptoms. The effects of ovarian hormones on sleep and cognitive processes have been studied in separate research fields that seldom intersect. However, sleep has a considerable impact on cognitive function. Given the tight connections between sleep and cognition, ovarian hormones may influence selective aspects of cognition indirectly, via the modulation of sleep...
August 9, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28802895/physical-activity-and-obesity-among-nine-year-old-children-with-and-without-chronic-health-problems-illness-or-disabilities-in-ireland
#4
Justin A Haegele, Sean Healy, Xihe Zhu
BACKGROUND: Regular engagement in physical activity can help youth control their weight during childhood while decreasing one's chances of developing chronic diseases (e.g., coronary heart disease, diabetes) throughout the lifespan. While numerous studies have explored physical activity participation and weight status among typically developing children, few epidemiological studies utilizing nationally representative data has focused on children with chronic health problems, illness, or disabilities (CHID)...
August 8, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28802842/the-role-of-g-protein-coupled-receptors-in-lymphoid-malignancies
#5
REVIEW
Adrienne Nugent, Richard L Proia
B cell lymphoma consists of multiple individual diseases arising throughout the lifespan of B cell development. From pro-B cells in the bone marrow, through circulating mature memory B cells, each stage of B cell development is prone to oncogenic mutation and transformation, which can lead to a corresponding lymphoma. Therapies designed against individual types of lymphoma often target features that differ between malignant cells and the corresponding normal cells from which they arise. These genetic changes between tumor and normal cells can include oncogene activation, tumor suppressor gene repression and modified cell surface receptor expression...
August 9, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28802720/application-of-green-fluorescent-protein-to-measure-antimicrobial-efficacy-and-the-kinetics-of-cell-death-against-escherichia-coli
#6
Richard Greenhalgh, Malcolm Greenhalgh, Fadwa Alshareef, Geoffrey D Robson
Industrial antimicrobials have been extensively used to control unwanted microbial growth by incorporation into a variety of products such as plastics and paints, reducing biodeterioration and biofouling and extending the lifespan of the product. Industrial antimicrobials generally have broad sites of action affecting core cellular functions such as central metabolism, enzyme function, cell wall or DNA synthesis and can either be biocidal or biostatic. In addition, susceptibility can be affected by the metabolic state of the microbe, with metabolically inactive cells generally more resistant than metabolically active cells...
August 9, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28797941/comprehensive-in-vitro-and-in-vivo-risk-assessments-of-chitosan-microparticles-using-human-epithelial-cells-and-caenorhabditis-elegans
#7
Zhengxin Ma, Alejandro Garrido-Maestu, Choonghee Lee, Jungwhan Chon, Daehee Jeong, Yiren Yue, Kidon Sung, Yeonhwa Park, Kwangcheol Casey Jeong
The safety of using nano- and microparticles is a developing concern. In this study, we conducted risk assessments of chitosan microparticles (CMs) using in vitro human epithelial cell lines and in vivo animal model, Caenorhabditis elegans. After engineering of various CMs, we screened four CMs based on antimicrobial activity, which is a potential usage for disease treatment caused by multidrug resistant bacteria, and evaluated for risk assessments. CMs, with strong antimicrobial activity, and inorganic nanoparticles (SiO2, TiO2, and ZnO) did not cause toxicity in human cells measured by cell membrane integrity, mitochondria activity, and reactive oxygen species concentration...
August 1, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28796386/heat-shock-protein-70-from-a-thermotolerant-diptera-species-provides-higher-thermoresistance-to-drosophila-larvae-than-correspondent-endogenous-gene
#8
V Y Shilova, O G Zatsepina, D G Garbuz, S Y Funikov, E S Zelentsova, N G Schostak, A M Kulikov, M B Evgen'ev
Heat shock proteins (Hsp70s) from two Diptera species that drastically differ in their heat shock response and longevity were investigated. Drosophila melanogaster is characterized by the absence of Hsp70 and other hsps under normal conditions and the dramatic induction of hsp synthesis after temperature elevation. The other Diptera species examined belongs to the Stratiomyidae family (Stratiomys singularior) and exhibits high levels of inducible Hsp70 under normal conditions coupled with a thermotolerant phenotype and much longer lifespan...
August 10, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/28795217/animals-living-in-polluted-environments-are-a-potential-source-of-anti-tumor-molecule-s
#9
REVIEW
Shareni Jeyamogan, Naveed Ahmed Khan, Ruqaiyyah Siddiqui
Despite advances in therapeutic interventions and supportive care, the morbidity and mortality associated with cancer have remained significant. Thus, there is a need for newer and more powerful anti-tumor agents. The search for new anti-tumor compounds originating from natural resources is a promising research area. Animals living in polluted environments are a potent source of anti-tumor agents. Under polluted milieus, species such as crocodiles, feed on rotten meat, are exposed to heavy metals, endure high levels of radiation, and are among the very few species to survive the catastrophic Cretaceous-Tertiary extinction event with a prolonged lifespan...
August 9, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28783712/machine-learning-for-predicting-lifespan-extending-chemical-compounds
#10
Diogo G Barardo, Danielle Newby, Daniel Thornton, Taravat Ghafourian, João Pedro de Magalhães, Alex A Freitas
Increasing age is a risk factor for many diseases; therefore developing pharmacological interventions that slow down ageing and consequently postpone the onset of many age-related diseases is highly desirable. In this work we analyse data from the DrugAge database, which contains chemical compounds and their effect on the lifespan of model organisms. Predictive models were built using the machine learning method random forests to predict whether or not a chemical compound will increase Caenorhabditis elegans' lifespan, using as features Gene Ontology (GO) terms annotated for proteins targeted by the compounds and chemical descriptors calculated from each compound's chemical structure...
July 18, 2017: Aging
https://www.readbyqxmd.com/read/28782473/importance-of-hemolysis-and-its-clinical-detection-in-neonates-with-hyperbilirubinemia
#11
Ronald J Wong, Vinod K Bhutani, David K Stevenson
Neonatal hyperbilirubinemia is generally a benign transitional phenomenon, and may even be a protective antioxidant mechanism for human neonates who may be vulnerable to the oxidative stress (compared to life in utero) encountered during birth an extra-uterine oxidative environment (1, 2). The pathophysiologic impact of neonatal unconjugated hyperbilirubinemia has been well reviewed in this supplement (see Jon fill-in). The severity of hyperbilirubinemia varies due to the magnitude of an imbalance between two major contributing processes: (i) an increase bilirubin production rate due to an increase in heme turnover (two to three times that of an adult) due to the degradation of fetal red blood cells (RBCs), which have a shortened lifespan, after birth (3, 4); and/or (ii) a diminished ability of the immature newborn liver to conjugate bilirubin and therefore excrete bilirubin in bile...
August 7, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28781934/signaling-in-parasitic-nematodes-physicochemical-communication-between-host-and-parasite-and-endogenous-molecular-transduction-pathways-governing-worm-development-and-survival
#12
James B Lok
Signaling or communication between host and parasite may occur over relatively long ranges to enable host finding and acquisition by infective parasitic nematode larvae. Innate behaviors in infective larvae transmitted from the soil that enhance the likelihood of host contact, such as negative geotaxis and hypermotility, are likely mediated by mechanoreception and neuromuscular signaling. Host cues such as vibration of the substratum, elevated temperature, exhaled CO2, and other volatile odorants are perceived by mechanosensory and chemosensory neurons of the amphidial complex...
December 2016: Current Clinical Microbiology Reports
https://www.readbyqxmd.com/read/28781785/effect-of-age-on-the-development-of-chemotherapy-associated-liver-injury-in-colorectal-cancer-liver-metastasis
#13
Taiichi Wakiya, Daisuke Kudo, Keinosuke Ishido, Norihisa Kimura, Yuta Yakoshi, Yoshikazu Toyoki, Hiroshi Kijima, Kenichi Hakamada
With the prolongation of the mean lifespan, the number of elderly individuals undergoing liver resection for colorectal cancer liver metastasis (CRLM) following chemotherapy has increased. However, the effect of age on the development of chemotherapy-associated liver injury (CALI) in CRLM remains unclear. The aim of the present study was to elucidate the effect of age on the development of CALI in CRLM. A total of 64 patients undergoing liver resection for CRLM following oxaliplatin-based chemotherapy (OBC) were investigated...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28771863/sex-specific-compensatory-growth-in-the-larvae-of-the-greater-wax-moth-galleria-mellonella
#14
Sanita Kecko, Anna Mihailova, Katariina Kangassalo, Didzis Elferts, Tatjana Krama, Ronalds Krams, Severi Luoto, Markus J Rantala, Indrikis A Krams
Deficiency of food resources in ontogeny is known to prolong an organism's developmental time and affect body size in adulthood. Yet life history traits are plastic: an organism can increase its growth rate to compensate for a period of slow growth, a phenomenon known as 'compensatory growth'. We tested whether larvae of the greater wax moth Galleria mellonella can accelerate their growth after a fast of 12, 24 or 72 h. We found that a subgroup of female larvae showed compensatory growth when starved for 12 h...
August 3, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28771106/end-state-comfort-across-the-lifespan-a-cross-sectional-investigation-of-how-movement-context-influences-motor-planning-in-an-overturned-glass-task
#15
Sara M Scharoun, David A Gonzalez, Eric A Roy, Pamela J Bryden
Young adults plan actions in advance to minimize the cost of movement. This is exemplified by the end-state comfort effect (ESC). A pattern of improvement in ESC in children is linked to the development of cognitive control processes, and decline in older adults' is attributed to cognitive decline. This study used a cross-sectional design to examine how movement context (pantomime, demonstrate with image/glass as a guide, actual grasping) influences between-hand differences in ESC planning. Children (5- to 12-year-olds), young adults and two groups of older adults (ages 60 to 70, and ages 71+) were assessed...
August 3, 2017: Motor Control
https://www.readbyqxmd.com/read/28770663/a-successful-model-for-clinical-training-in-child-adolescent-cognitive-behavior-therapy-for-graduate-psychiatric-advanced-practice-nursing-students
#16
Pamela Lusk, Beverly G Hart Abney, Bernadette Mazurek Melnyk
BACKGROUND: Graduate faculty in advanced practice nursing programs seek to provide clinical training in psychotherapy for psychiatric mental health nurse practitioner (PMHNP) students and prepare them for practice with patients across the lifespan, including children and adolescents. OBJECTIVE: To develop a clinical training model for child/adolescent cognitive behavior therapy (CBT) that is adaptable to all graduate nursing programs including online, classroom, and blended programs...
August 1, 2017: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/28770217/dairy-cows-naturally-infected-with-bovine-leukemia-virus-exhibit-abnormal-b-and-t-cell-phenotypes-after-primary-and-secondary-exposures-to-keyhole-limpet-hemocyanin
#17
Meredith C Frie, Kelly R B Sporer, Oscar J Benitez, Joseph C Wallace, Casey J Droscha, Paul C Bartlett, Paul M Coussens
Bovine leukemia virus (BLV) is a retrovirus that is highly prevalent in US dairy herds: over 83% are BLV infected and the within-herd infection rate can be almost 50% on average. While BLV is known to cause lymphosarcomas, only 5% or fewer infected cattle will develop lymphoma; this low prevalence of cancer has historically not been a concern to dairy producers. However, more recent research has found that BLV(+) cows without lymphoma produce less milk and have shorter lifespans than uninfected herdmates. It has been hypothesized that BLV infection interferes with normal immune function in infected cattle, and this could lead to reduced dairy production...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28770013/relational-developmental-systems-metatheory-a-conceptual-framework-to-understand-and-promote-older-adults-involvement-in-sport
#18
REVIEW
Amy M Gayman, Jessica Fraser-Thomas, Joseph Baker
Sport is viewed as a vehicle to develop or augment adaptive developmental processes, resources, and experiences across the lifespan. However, research has acknowledged that sport participation is associated with costs as well as benefits in older adulthood. To fully understand the influence of sport participation on psychosocial and developmental outcomes in older people, insight into the dynamic and complex relationship between the individual and his/her environment is needed. This review proposes Relational Developmental Systems (RDS) metatheory as a conceptual framework to understand the outcomes of sport participation later in life...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28769873/targeting-obesity-and-diabetes-to-treat-heart-failure-with-preserved-ejection-fraction
#19
REVIEW
Raffaele Altara, Mauro Giordano, Einar S Nordén, Alessandro Cataliotti, Mazen Kurdi, Saeed N Bajestani, George W Booz
Heart failure with preserved ejection fraction (HFpEF) is a major unmet medical need that is characterized by the presence of multiple cardiovascular and non-cardiovascular comorbidities. Foremost among these comorbidities are obesity and diabetes, which are not only risk factors for the development of HFpEF, but worsen symptoms and outcome. Coronary microvascular inflammation with endothelial dysfunction is a common denominator among HFpEF, obesity, and diabetes that likely explains at least in part the etiology of HFpEF and its synergistic relationship with obesity and diabetes...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28766905/evidence-for-reduced-neurogenesis-in-the-aging-human-hippocampus-despite-stable-stem-cell-markers
#20
Kathryn J Mathews, Katherine M Allen, Danny Boerrigter, Helen Ball, Cynthia Shannon Weickert, Kay L Double
Reduced neurogenesis in the aging mammalian hippocampus has been linked to cognitive deficits and increased risk of dementia. We utilized postmortem human hippocampal tissue from 26 subjects aged 18-88 years to investigate changes in expression of six genes representing different stages of neurogenesis across the healthy adult lifespan. Progressive and significant decreases in mRNA levels of the proliferation marker Ki67 (MKI67) and the immature neuronal marker doublecortin (DCX) were found in the healthy human hippocampus over the lifespan...
August 1, 2017: Aging Cell
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