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Lifespan development

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https://www.readbyqxmd.com/read/28230097/evidence-for-risk-extrapolation-in-decision-making-by-tadpoles
#1
Adam L Crane, Maud C O Ferrari
Through time, the activity patterns, morphology, and development of both predators and prey change, which in turn alter the relative vulnerability of prey to their coexisting predators. Recognizing these changes can thus allow prey to make optimal decisions by projecting risk trends into the future. We used tadpoles (Lithobates sylvaticus) to test the hypothesis that tadpoles can extrapolate information about predation risk from past information. We exposed tadpoles to an odour that represented either a temporally consistent risk or an increasing risk...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229260/dehydroepiandrosterone-sulfate-dhea-s-sex-and-age-in-zoo-housed-western-lowland-gorillas-gorilla-gorilla-gorilla
#2
Ashley N Edes
Among humans, dehydroepiandrosterone-sulfate (DHEA-S) declines with age and is hypothesized to be involved in somatic maintenance and healthy aging. Men have significantly higher DHEA-S than women, contradicting longer lifespans in the latter. Declines of DHEA-S with age also are observed in chimpanzees. In both chimpanzees and bonobos, males and females show no differences in DHEA-S production. Based on human and chimpanzee data, gorillas were predicted to show declining DHEA-S with age. Similar to chimpanzees and bonobos, it also was predicted DHEA-S would not be significantly different between males and females...
February 22, 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/28215989/klotho-regulates-ca1-hippocampal-synaptic-plasticity
#3
Qin Li, Hai T Vo, Jing Wang, Stephanie Fox-Quick, Lynn E Dobrunz, Gwendalyn D King
Global klotho overexpression extends lifespan while global klotho-deficiency shortens it. As well, klotho protein manipulations inversely regulate cognitive function. Mice without klotho develop rapid onset cognitive impairment before they are 2months old. Meanwhile, adult mice overexpressing klotho show enhanced cognitive function, particularly in hippocampal-dependent tasks. The cognitive enhancing effects of klotho extend to humans with a klotho polymorphism that increases circulating klotho and executive function...
February 12, 2017: Neuroscience
https://www.readbyqxmd.com/read/28212626/a-global-characterization-of-the-translational-and-transcriptional-programs-induced-by-methionine-restriction-through-ribosome-profiling-and-rna-seq
#4
Ke Zou, Qi Ouyang, Hao Li, Jiashun Zheng
BACKGROUND: Among twenty amino acids, methionine has a special role as it is coded by the translation initiation codon and methionyl-tRNAi (Met-tRNAi) is required for the assembly of the translation initiation complex. Thus methionine may play a special role in global gene regulation. Methionine has also been known to play important roles in cell growth, development, cancer, and aging. In this work, we characterize the translational and transcriptional programs induced by methionine restriction (MetR) and investigate the potential mechanisms through which methionine regulates gene expression, using the budding yeast S...
February 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28212591/maternal-bonding-through-pregnancy-and-postnatal-findings-from-an-australian-longitudinal-study
#5
Larissa Rossen, Delyse Hutchinson, Judy Wilson, Lucinda Burns, Steve Allsop, Elizabeth J Elliott, Sue Jacobs, Jacqui A Macdonald, Craig Olsson, Richard P Mattick
Background Mother-infant bonding provides the foundation for secure attachment through the lifespan and organizes many facets of infant social-emotional development, including later parenting. Aims To describe maternal bonding to offspring across the pregnancy and postnatal periods, and to examine a broad range of sociodemographic and psychosocial predictors of the maternal-offspring bond. Methods Data were drawn from a sample of 372 pregnant women participating in an Australian population-based longitudinal study of postnatal health and development...
February 17, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28210535/magnetic-resonance-imaging-in-a-neurofibromatosis-type-2-patient-with-a-novel-mri-compatible-auditory-brainstem-implant
#6
REVIEW
Matthew Shew, Judson Bertsch, Paul Camarata, Hinrich Staecker
Auditory brainstem implantation has become a key technique for the rehabilitation of hearing in patients with neurofibromatosis type 2. The nature of this devastating genetic disease requires ongoing MRI for the patient's lifespan. Today, most auditory brainstem implants require removal of the magnet that connects the internal device to the external speech processor to undergo imaging as their disease progresses. Patients have the option of having a short procedure to have the magnet taken out and replaced each time, or alternately using a headband to secure the processor over the receiver coil of the internal device...
January 2017: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/28210260/from-the-cradle-to-the-grave-the-role-of-macrophages-in-erythropoiesis-and-erythrophagocytosis
#7
REVIEW
Thomas R L Klei, Sanne M Meinderts, Timo K van den Berg, Robin van Bruggen
Erythropoiesis is a highly regulated process where sequential events ensure the proper differentiation of hematopoietic stem cells into, ultimately, red blood cells (RBCs). Macrophages in the bone marrow play an important role in hematopoiesis by providing signals that induce differentiation and proliferation of the earliest committed erythroid progenitors. Subsequent differentiation toward the erythroblast stage is accompanied by the formation of so-called erythroblastic islands where a central macrophage provides further cues to induce erythroblast differentiation, expansion, and hemoglobinization...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28206881/loss-of-permanent-first-molars-in-the-mixed-dentition-circumstances-resulting-in-extraction-and-requiring-orthodontic-management
#8
Kavita R Mathu-Muju, David B Kennedy
Extraction of significantly compromised permanent first molars may be indicated during the mixed dentition stage of occlusal development. The purpose of this article was to review circumstances that can result in the loss of a permanent first molar-including dental caries, molar incisor hypomineralization, eruption disturbances of permanent teeth, and failure of restorative treatment to affirm that a complete dental arch is not necessary for the existence of a functional dental arch. The extraction of permanent first molar(s) with subsequent orthodontic treatment in a young patient can be considered a cost-effective alternative to placing complex restorations that require replacement over the lifespan...
October 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28204902/-medical-rehabilitation-from-a%C3%A2-lifespan-perspective
#9
Michael Linden, Sebastian Bernert, Ariane Funke, Karsten E Dreinhöfer, Michael Jöbges, Ernst von Kardorff, Steffi G Riedel-Heller, Karla Spyra, Heinz Völler, Petra Warschburger, Pia-Maria Wippert
Lifespan research investigates the development of individuals over the course of life. As medical rehabilitation deals with primary and secondary prophylaxis, treatment, and compensation of chronic illnesses, a lifespan perspective is needed for the classification and diagnosis of chronic disorders, the assessment of course modifying factors, the identification of vulnerable life periods and critical incidents, the implementation of preventive measures, the development of methods for the evaluation of prior treatments, the selection and prioritization of interventions, including specialized inpatient rehabilitation, the coordination of therapies and therapists, and for evaluations in social and forensic medicine...
February 15, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28203146/insulin-like-growth-factor-1-at-the-crossroads-of-brain-development-and-aging
#10
REVIEW
Sarah Wrigley, Donia Arafa, Daniela Tropea
Insulin-like growth factor 1 (IGF1) is a polypeptide hormone structurally similar to insulin. It is central to the somatotropic axis, acting downstream of growth hormone (GH). It activates both the mitogen-activated protein (MAP) kinase and PI3K signaling pathways, acting in almost every tissue in the body to promote tissue growth and maturation through upregulation of anabolic processes. Overall GH and IGF1 signaling falls with age, suggesting that it is this reduced IGF1 activity that leads to age-related changes in organisms...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28202594/surface-microtopography-modulates-sealing-zone-development-in-osteoclasts-cultured-on-bone
#11
Michal Shemesh, Lia Addadi, Benjamin Geiger
Bone homeostasis is continuously regulated by the coordinated action of bone-resorbing osteoclasts and bone-forming osteoblasts. Imbalance between these two cell populations leads to pathological bone diseases such as osteoporosis and osteopetrosis. Osteoclast functionality relies on the formation of sealing zone (SZ) rings that define the resorption lacuna. It is commonly assumed that the structure and dynamic properties of the SZ depend on the physical and chemical properties of the substrate. Considering the unique complex structure of native bone, elucidation of the relevant parameters affecting SZ formation and stability is challenging...
February 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28202322/sexual-health-competencies-for-undergraduate-medical-education-in-north-america
#12
Carey Roth Bayer, Kristen L Eckstrand, Gail Knudson, Jean Koehler, Scott Leibowitz, Perry Tsai, Jamie L Feldman
INTRODUCTION: The number of hours spent teaching sexual health content and skills in medical education continues to decrease despite the increase in sexual health issues faced by patients across the lifespan. In 2012 and 2014, experts across sexuality disciplines convened for the Summits on Medical School Education and Sexual Health to strategize and recommend approaches to improve sexual health education in medical education systems and practice settings. One of the summit recommendations was to develop sexual health competencies that could be implemented in undergraduate medical education curricula...
February 12, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28197675/erratum-to-lifespan-development-of-the-bilateral-deficit-in-a-simple-reaction-time-task
#13
Solveig Vieluf, Gisa Aschersleben, Stefan Panzer
No abstract text is available yet for this article.
February 15, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28196778/mucopolysaccharidoses-seen-in-adults-in-rheumatology
#14
Stéphane Mitrovic, Hélène Gouze, Laure Gossec, Thierry Schaeverbeke, Bruno Fautrel
Mucopolysaccharidoses are a group of rare lysosomal storage diseases including a great number of polymorph syndromes, each being related to a particular mutation responsible for a deficiency of glycosaminoglycan degrading enzymes, leading to an accumulation of glycosaminoglycans in tissues. Many of them are diagnosed in children or teenagers and have a severe prognosis because of organ failure, and are consequently usually not seen by the adult rheumatologist. However, some of them have a more progressive presentation, with musculoskeletal symptoms at the forefront and a lifespan that nearly reaches that of the general population...
February 11, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28196559/the-link-between-childhood-adversity-and-late-life-mental-health-evidence-for-the-influence-of-early-life-experiences-or-illusory-correlations
#15
Tracy D Vannorsdall, Cynthia A Munro
Adverse childhood experiences (ACEs) reflect stressful or traumatic early life events such as abuse, neglect, and significant household challenges. These experiences are increasingly appreciated as factors that exert influence on physical and mental functioning throughout the lifespan. Numerous studies have demonstrated dose-response relationships between the number of ACEs reported and negative health outcomes in adulthood (Anda et al., 2006). At the same time, evidence points to the role of ACEs in the development of heightened biological reactivity to stress that may serve to increase vulnerability to the development of mental and substance use disorders (e...
March 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28194614/the-exposome-research-paradigm-an-opportunity-to-understand-the-environmental-basis-for-human-health-and-disease
#16
REVIEW
Germaine M Buck Louis, Melissa M Smarr, Chirag J Patel
PURPOSE OF REVIEW: This paper presents an overview of the exposome research paradigm with particular application to understanding human reproduction and development and its implications for health across a lifespan. RECENT FINDINGS: The exposome research paradigm has generated considerable discussion about its feasibility and utility for delineating the impact of environmental exposures on human health. Early initiatives are underway, including smaller proof-of-principle studies and larger concerted efforts...
February 13, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28194146/modulation-of-replicative-lifespan-in-cryptococcus-neoformans-implications-for-virulence
#17
Tejas Bouklas, Neena Jain, Bettina C Fries
The fungal pathogen, Cryptococcus neoformans, has been shown to undergo replicative aging. Old cells are characterized by advanced generational age and phenotypic changes that appear to mediate enhanced resistance to host and antifungal-based killing. As a consequence of this age-associated resilience, old cells accumulate during chronic infection. Based on these findings, we hypothesized that shifting the generational age of a pathogenic yeast population would alter its vulnerability to the host and affect its virulence...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28185600/health-and-lifestyle-factors-associated-with-sexual-difficulties-in-men-results-from-a-study-of-australian-men-aged-18-to-55%C3%A2-years
#18
Marisa Schlichthorst, Lena A Sanci, Jane S Hocking
BACKGROUND: Sexual difficulties (SD) are common among men of all ages and can have considerable impact on quality of life and indications for future health. SD are associated with mental and physical wellbeing and with relationship satisfaction, yet they are rarely discussed with medical professionals who are often ill equipped to assess and manage them. This paper provides an updated overview on the status of SD in Australian men from 18 to 55 years of age and will form a baseline comparison for future analyses of SD based on Ten to Men data...
October 31, 2016: BMC Public Health
https://www.readbyqxmd.com/read/28185536/a-new-anti-aging-lysophosphatidic-acid-from-arabidopsis-thaliana
#19
Yujuan Sun, Yanhui Wang, Guangfa Wang, Lan Xiang, Jianhua Qi
BACKGROUND: Aging is a risk factor of age-related diseases. With the increasing number of patients, serious consequences, and heavy economic burden, demands for drugs used to treat age-related diseases have increased. As such, anti-aging substances should be isolated to develop drugs for the prevention and treatment of age-related diseases. METHODS: In this study, a methanol extract of immature Arabidopsis thaliana seeds with coat was separated by using a K6001 yeast bioassay system...
February 9, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28167240/pharmacological-intervention-of-early-neuropathy-in-neurodegenerative-diseases
#20
REVIEW
Min Jee Kwon, Jeong-Hoon Kim, TaeSoo Kim, Sung Bae Lee
Extensive studies have reported the significant roles of numerous cellular features and processes in properly maintaining neuronal morphology and function throughout the lifespan of an animal. Any alterations in their homeostasis appear to be strongly associated with neuronal aging and the pathogenesis of various neurodegenerative diseases, even before the occurrence of prominent neuronal death. However, until recently, the primary focus of studies regarding many neurodegenerative diseases has been on the massive cell death occurring at the late stages of disease progression...
February 4, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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