Zekai Wu, Jian Zhang, Yajiao Wu, Mengting Chen, Hong Hu, Xinyue Gao, Chutao Li, Maodong Li, Youbo Zhang, Xiaohuang Lin, Qiaomei Yang, Li Chen, Kunqi Chen, Lifeng Zheng, An Zhu
Gelsemium elegans Benth. (G. elegans) is a traditional medicinal herb that has anti-inflammatory, analgesic, sedative, and detumescence effects. However, it can also cause intestinal side effects such as abdominal pain and diarrhea. The toxicological mechanisms of gelsenicine are still unclear. The objective of this study was to assess enterotoxicity induced by gelsenicine in the nematodes Caenorhabditis elegans (C. elegans). The nematodes were treated with gelsenicine, and subsequently their growth, development, and locomotion behavior were evaluated...
May 3, 2024: Chemico-biological Interactions