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https://www.readbyqxmd.com/read/28706191/aldehyde-dehydrogenase-1-positive-nigrostriatal-dopaminergic-fibers-exhibit-distinct-projection-pattern-and-dopamine-release-dynamics-at-mouse-dorsal-striatum
#1
Carmelo Sgobio, Junbing Wu, Wang Zheng, Xi Chen, Jing Pan, Armando G Salinas, Margaret I Davis, David M Lovinger, Huaibin Cai
Aldehyde dehydrogenase 1 (ALDH1A1)-positive dopaminergic (DA) neurons at the ventral substantia nigra pars compacta (SNpc) preferentially degenerate in Parkinson's disease (PD). Their projection pattern and dopamine release properties, however, remains uncharacterized. Here we show that ALDH1A1-positive axons project predominantly to the rostral two-thirds of dorsal striatum. A portion of these axons converge on a small fraction of striosome compartments restricted to the dorsolateral striatum (DLS), where less dopamine release was measured compared to the adjacent matrix enriched with the ALDH1A1-negative axons...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28687469/endoscope-assisted-neurectomy-and-inferior-alveolar-nerve-avulsion-in-treating-trigeminal-neuralgia
#2
Daiying Huang, Shuangxi Zhu, Junbing Guo, Songling Chen
OBJECTIVE: To explore endoscope-assisted surgical treatment for idiopathic trigeminal neuralgia (TN), with neurectomy and avulsion of the inferior alveolar nerve (IAN), when patients are not willing to undergo intracranial procedures. CLINICAL MATERIALS AND METHODS: Five TN patients with inferior alveolar neuralgia in the mandibular branch were admitted; endoscope-assisted inferior alveolar neurectomy and avulsion was performed for TN treatment. Clinical observation and postoperative follow-up were conducted...
June 15, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28659618/an-oncogenic-axis-of-stat-mediated-batf3-upregulation-causing-myc-activity-in-classical-hodgkin-lymphoma-and-anaplastic-large-cell-lymphoma
#3
A Lollies, S Hartmann, M Schneider, T Bracht, A Weiß, J Arnolds, L Klein-Hitpass, B Sitek, M-L Hansmann, R Küppers, M A Weniger
Classical Hodgkin lymphoma (cHL) and anaplastic large cell lymphoma (ALCL) feature high expression of AP-1 transcription factors, which regulate various physiological processes but also promote lymphomagenesis. The AP-1 factor basic leucine zipper transcription factor, ATF-like 3 (BATF3) is highly transcribed in cHL and ALCL; however, its functional importance in lymphomagenesis is unknown. Here we show that proto-typical CD30(+) lymphomas, namely cHL (21/30) and primary mediastinal B-cell lymphoma (8/9), but also CD30(+) diffuse large B-cell lymphoma (15/20) frequently express BATF3 protein...
June 29, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28589371/activator-protein-1-ap-1-a-bridge-between-life-and-death-in-lung-epithelial-a549-cells-under-hypoxia
#4
Seema Yadav, Namita Kalra, Lilly Ganju, Mrinalini Singh
Activator protein-1 (AP-1) transcription factor plays a central role in hypoxia to modulate the expression of genes that decides the fate of the cell. The aim of the present study was to explore the role of AP-1 subunits in lung epithelial (A549) cells under hypoxia. Cell cycle studies by flow cytometry indicated that cell viability was unaffected by the initial hypoxia exposure (0.5% O2 at 37 °C) for 6 and 12 h. However, both transient cell cycle arrest and cell death was detected at 24 and 48 h. Flow cytometry and spectrofluorometry data confirmed the increase in ROS levels...
June 6, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28588686/effect-of-continuous-renal-replacement-therapy-on-kidney-injury-molecule-1-and-neutrophil-gelatinase-associated-lipocalin-in-patients-with-septic-acute-kidney-injury
#5
Yiming Shao, Yinqiang Fan, Yuliu Xie, Lu Yin, Yuanli Zhang, Liehua Deng, Xiaocong Sun, Xin Shao, Xinzhang Tan, Junbing He, Shiman Zhao
Kidney injury molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (NGAL) have been investigated as biomarkers for acute kidney injury (AKI). However, they are seldom investigated in patients with septic AKI treated with continuous renal replacement therapy (CRRT). The aim of the present study was to investigate the therapeutic effectiveness and possible mechanisms of CRRT in septic AKI by observing the changes in Kim-1 and NGAL levels. A group of 38 patients with septic AKI was randomly divided into the conventional drug treatment group (group A) and the CRRT group (group B)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28586006/butein-inhibits-nf-%C3%AE%C2%BAb-ap-1-and-akt-activation-in-adult-t-cell-leukemia-lymphoma
#6
Chie Ishikawa, Masachika Senba, Naoki Mori
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL) but there is no effective treatment for HTLV-1-associated diseases. Herein, we determined the effect of butein, a bioactive plant polyphenol, on cell growth, apoptosis and signaling pathways in HTLV-1-infected T-cell lines and on tumor growth in SCID mice. Treatment with butein caused a decrease in viability of HTLV-1-infected T-cell lines. T cells cultured with butein showed obvious apoptosis morphology, and cleavage of poly(ADP-ribose) polymerase with activation of caspase-3, -8 and -9...
June 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28555647/junb-is-essential-for-il-23-dependent-pathogenicity-of-th17-cells
#7
Zafrul Hasan, Shin-Ichi Koizumi, Daiki Sasaki, Hayato Yamada, Nana Arakaki, Yoshitaka Fujihara, Shiho Okitsu, Hiroki Shirahata, Hiroki Ishikawa
CD4(+) T-helper cells producing interleukin-17 (IL-17), known as T-helper 17 (TH17) cells, comprise heterogeneous subsets that exhibit distinct pathogenicity. Although pathogenic and non-pathogenic TH17 subsets share a common RORγt-dependent TH17 transcriptional programme, transcriptional regulatory mechanisms specific to each of these subsets are mostly unknown. Here we show that the AP-1 transcription factor JunB is critical for TH17 pathogenicity. JunB, which is induced by IL-6, is essential for expression of RORγt and IL-23 receptor by facilitating DNA binding of BATF at the Rorc locus in IL-23-dependent pathogenic TH17 cells, but not in TGF-β1-dependent non-pathogenic TH17 cells...
May 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28497398/early-markers-of-myocardial-ischemia-from-the-experimental-model-to-forensic-pathology-cases-of-sudden-cardiac-death
#8
Sara Sabatasso, Milena Moretti, Patrice Mangin, Tony Fracasso
The goal of this study was to assess whether early markers of myocardial ischemia, identified in a previous experimental work, can be applied in forensic pathology cases of sudden, ischemic cardiac death. These markers include desphosphorylated connexin 43 (Cx43), JunB, TUNEL assay, myoglobin, and troponin T. Fourteen cases of sudden cardiac death with gross and/or histological signs of myocardial infarction and 14 cases of sudden cardiac death with signs of early ischemia at histology and positive immunoreactions for fibronectin and C5b-9 were investigated...
May 11, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28472164/association-study-of-mcp-1-promoter-polymorphisms-with-the-susceptibility-and-progression-of-sepsis
#9
Junbing He, Yuhua Chen, Yao Lin, Wenying Zhang, Yujie Cai, Feng Chen, Qinghui Liao, Zihan Yin, Yan Wang, Shoubao Tao, Xiaoli Lin, Pengru Huang, Lili Cui, Yiming Shao
Previous studies have indicated that the monocyte chemo-attractant protein 1 (MCP-1), also referred to as C-C motif chemokine ligand 2 (CCL2), plays a significant role in the pathogenesis of sepsis, and this study investigated the clinical relevance of two MCP-1 gene polymorphisms on sepsis onset and progression. The Multiplex SNaPshot genotyping method was used to detect MCP-1 gene polymorphisms in the Chinese Han population (403 sepsis patients and 400 controls). MCP-1 mRNA expression levels were measured using real-time quantitative PCR, and enzyme-linked immunosorbent assays were used to analyze MCP-1, tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and interleukin-1 beta (IL-1β) plasma concentrations...
2017: PloS One
https://www.readbyqxmd.com/read/28458545/role-of-hedgehog-gli1-signaling-in-the-enhanced-proliferation-and-differentiation-of-mg63-cells-enabled-by-hierarchical-micro-nanotextured-topography
#10
Yao Lin, Yinghe Huang, Junbing He, Feng Chen, Yanfang He, Wenying Zhang
Hedgehog-Gli1 signaling is evolutionarily conserved and plays an essential role in osteoblast proliferation and differentiation as well as bone formation. To evaluate the role of the Hedgehog-Gli1 pathway in the response of osteoblasts to hierarchical biomaterial topographies, human MG63 osteoblasts were seeded onto smooth, microstructured, and micro-/nanotextured topography (MNT) titanium to assess osteoblast proliferation and differentiation in terms of proliferative activity, alkaline phosphatase (ALP) production, and osteogenesis-related gene expression...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28458013/aberrant-methylation-of-runx3-is-present-in-aflatoxin-b1-induced-transformation-of-the-l02r-cell-line
#11
Shan Wang, Zhini He, Daochuan Li, Bo Zhang, Miao Li, Wenxue Li, Wei Zhu, Xiumei Xing, Xiaowen Zeng, Qing Wang, Guanghui Dong, Yongmei Xiao, Wen Chen, Liping Chen
Chronic exposure to aflatoxin B1 (AFB1) is linked to the development of hepatocellular carcinoma (HCC). To identify differentially methylated genes involved in AFB1-induced cell transformation, we analyzed DNA methylation patterns in immortal human hepatocyte L02 cells expressing an oncogenic H-Ras allele (L02R cells) and AFB1-transformed L02R (L02RT-AFB1) cells by performing genome-wide methylation profiling. We treated L02R cells with 0.3μM AFB1 weekly and observed a transformed phenotype at the 17th week post-treatment...
June 15, 2017: Toxicology
https://www.readbyqxmd.com/read/28454334/taxotere-induced-elevated-expression-of-il8-in-carcinoma-associated-fibroblasts-of-breast-invasive-ductal-cancer
#12
Yingliang Li, Guohua Rong, Hua Kang
Breast cancer is the most common malignant tumor in women worldwide, and accounts for an estimated 29% of new cases and 15% of cancer-associated mortalities each year. Invasive ductal carcinoma represents 70-80% of all breast cancer cases, which are responsible for the majority of breast cancer fatalities. Though great progress has been made in understanding the tumorigenesis and development of breast cancer, problems surrounding treatment persist. It was previously reported that carcinoma-associated fibroblasts (CAFs) may be closely associated with chemotherapy resistance...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28423685/tumor-fibroblast-interactions-stimulate-tumor-vascularization-by-enhancing-cytokine-driven-production-of-mmp9-by-tumor-cells
#13
Michelle Limoge, Alfiya Safina, Amy Beattie, Lauren Kapus, Alexander M Truskinovsky, Andrei V Bakin
Advance-stage breast carcinomas include significant amounts of fibroblasts and infiltrating immune cells which have been implicated in tumor growth, recurrence, and response to therapy. The present study investigated the contribution of fibroblasts to tumor growth using direct tumor-fibroblast co-cultures and tumor xenograft models. Our findings revealed that fibroblasts enhance breast carcinoma growth by promoting the tumor vasculature via the MMP9-dependent mechanism. In tumor-fibroblast co-cultures, fibroblasts increased expression of TGF-β, TNF, and IL-1β cytokines in tumor cells...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28387248/mir-1827-inhibits-osteogenic-differentiation-by-targeting-igf1-in-msmscs
#14
ShuangXi Zhu, Wei Peng, Xiang Li, JunQuan Weng, Xing Zhang, JunBing Guo, DaiYing Huang, Qiong Rong, SongLing Chen
We recently reported that maxillary sinus membrane stem cells (MSMSCs) have osteogenic potential. However, the biological mechanisms of bone formation remain unclear. In this study, we investigated the role and mechanisms of microRNAs (miRNAs) in the osteogenic differentiation of MSMSCs. The expression of miRNAs was determined in differentiated MSMSCs by comprehensive miRNA microarray analysis and quantitative RT-PCR (qRT-PCR). We selected miR-1827 for functional follow-up studies to explore its significance in MSMSCs...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298358/identification-of-%C3%AE-catenin-interacting-proteins-in-nuclear-fractions-of-native-rat-collecting-duct-cells
#15
Jacqueline R Hwang, Chung-Lin Chou, Barbara Medvar, Mark A Knepper, Hyun Jun Jung
The gene encoding the aquaporin-2 water channel is regulated transcriptionally in response to vasopressin. In the renal collecting duct, vasopressin stimulates the nuclear translocation and phosphorylation (at Ser(552)) of β-catenin, a multifunctional protein that acts as a transcriptional coregulator in the nucleus. The purpose of this study was to identify β-catenin-interacting proteins that might be involved in transcriptional regulation in rat inner medullary collecting duct (IMCD) cells, using experimental and computational approaches...
July 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28155253/characterization-of-key-transcription-factors-as-molecular-signatures-of-hpv-positive-and-hpv-negative-oral-cancers
#16
Gaurav Verma, Kanchan Vishnoi, Abhishek Tyagi, Mohit Jadli, Tejveer Singh, Ankit Goel, Ankita Sharma, Kiran Agarwal, Subhash Chandra Prasad, Durgatosh Pandey, Shashi Sharma, Ravi Mehrotra, Sukh Mahendra Singh, Alok Chandra Bharti
Prior studies established constitutively active AP-1, NF-κB, and STAT3 signaling in oral cancer. Differential expression/activation of specific members of these transcription factors has been documented in HPV-positive oral lesions that respond better to therapy. We performed a comprehensive analysis of differentially expressed, transcriptionally active members of these pivotal signaling mediators to develop specific signatures of HPV-positive and HPV-negative oral lesions by immunohistochemical method that is applicable in low-resource settings...
March 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28096474/junb-regulates-angiogenesis-and-neurovascular-parallel-alignment-in-mouse-embryonic-skin
#17
Yasuo Yoshitomi, Takayuki Ikeda, Hidehito Saito, Yoshino Yoshitake, Yasuhito Ishigaki, Toshihisa Hatta, Nobuo Kato, Hideto Yonekura
Blood vessels and nerve fibers are often closely arranged in parallel throughout the body. Therefore, neurovascular interactions have been suggested to be important for the development of vascular networks. However, the molecular mechanisms and genes regulating this process remain unclear. In the present study, we investigated the genes that are activated in endothelial cells (ECs) following interactions with neurons during vascular development. Microarray analyses of human primary microvascular ECs co-cultured with mouse primary dorsal root ganglion cells showed that JunB is strongly upregulated in ECs by neurovascular interactions...
January 17, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28063039/xenotransplantation-model-of-psoriasis
#18
Jeremy Di Domizio, Curdin Conrad, Michel Gilliet
Psoriasis is a chronic autoimmune skin disease affecting approximately 2 % of the population with a major psychosocial and socioeconomic impact. A causal therapy leading to permanent cure is not available, and current treatments only lead to limited amelioration, and therefore new therapeutic targets need to be identified. Recent works demonstrated a predominant role of TH17 cells in the pathogenesis of psoriasis; yet the underlying molecular mechanisms driving the development of the disease are still largely elusive...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28005952/microrna-and-transcription-factor-gene-regulatory-network-analysis-reveals-key-regulatory-elements-associated-with-prostate-cancer-progression
#19
Mehdi Sadeghi, Bijan Ranjbar, Mohamad Reza Ganjalikhany, Faiz M Khan, Ulf Schmitz, Olaf Wolkenhauer, Shailendra K Gupta
Technological and methodological advances in multi-omics data generation and integration approaches help elucidate genetic features of complex biological traits and diseases such as prostate cancer. Due to its heterogeneity, the identification of key functional components involved in the regulation and progression of prostate cancer is a methodological challenge. In this study, we identified key regulatory interactions responsible for primary to metastasis transitions in prostate cancer using network inference approaches by integrating patient derived transcriptomic and miRomics data into gene/miRNA/transcription factor regulatory networks...
2016: PloS One
https://www.readbyqxmd.com/read/27992400/the-histone-demethylase-utx-regulates-the-lineage-specific-epigenetic-program-of-invariant-natural-killer-t-cells
#20
Semir Beyaz, Ji Hyung Kim, Luca Pinello, Michael E Xifaras, Yu Hu, Jialiang Huang, Marc A Kerenyi, Partha P Das, R Anthony Barnitz, Aurelie Herault, Rizkullah Dogum, W Nicholas Haining, Ömer H Yilmaz, Emmanuelle Passegue, Guo-Cheng Yuan, Stuart H Orkin, Florian Winau
Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development. Here we found that the H3K27me3 histone demethylase UTX was an essential cell-intrinsic factor that controlled an iNKT-cell lineage-specific gene-expression program and epigenetic landscape in a demethylase-activity-dependent manner. UTX-deficient iNKT cells exhibited impaired expression of iNKT cell signature genes due to a decrease in activation-associated H3K4me3 marks and an increase in repressive H3K27me3 marks within the promoters occupied by UTX...
February 2017: Nature Immunology
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