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Xènia Crespo-Yàñez, Carmen Aguilar-Gurrieri, Anne-Claire Jacomin, Agnès Journet, Magda Mortier, Emmanuel Taillebourg, Emmanuelle Soleilhac, Winfried Weissenhorn, Marie-Odile Fauvarque
Integration and down-regulation of cell growth and differentiation signals rely on plasma membrane receptors endocytosis and sorting towards either recycling vesicles or degradative lysosomes via multivesicular bodies (MVB). In this process, the endosomal sorting complex-III required for transport (ESCRT-III) controls membrane deformation and scission triggering intraluminal vesicle (ILV) formation at early endosomes. Here, we show that the ESCRT-III member CHMP1B can be ubiquitinated within a flexible loop known to undergo conformational changes during polymerization...
June 22, 2018: PLoS Genetics
Christos I Ioannou, Martin K Klämpfl, Babett H Lobinger, Markus Raab, Eckart Altenmüller
PURPOSE: Similar to musician's focal dystonia a task-specific phenomenon, known as yips has also been reported in professional athletes. Yips is usually described as focal dystonia, or choking under pressure, or as lying on a continuum between both. Based on the common occupational conditions across musicians and athletes, the present exploratory study aimed to investigate whether musicians diagnosed with focal dystonia and golfers affected with yips, can be similarly sub-classified based on their psychological profiles...
June 21, 2018: Medicine and Science in Sports and Exercise
Liqiu Zhang, Hee-Jeong Jang, Sung Jae Yoo, Sanghyun Cho, Ji Hye Won, Lichun Liu, Sungho Park
Site-selective synthesis of nanostructures is an important topic in the nanoscience community. Normally, the difference between seeds and deposition atoms in terms of crystallinity triggers the deposition atoms to grow initially at the specific site of nucleation. It is more challenging to control the deposition site of atoms that have the same composition as the seeds because the atoms tend to grow epitaxially, covering the whole surface of the seed nanoparticles. Gold (Au) nano-octahedrons used as seeds in this study possess obvious hierarchical surface energies depending on whether they are at vertices, edges, or terraces...
June 22, 2018: Nanotechnology
Lynn Huestegge, Aleks Pieczykolan, Markus Janczyk
In dual-task situations, which often involve some form of sequential task processing, features of Task 2 were shown to affect Task 1 performance, a phenomenon termed "backward crosstalk effect" (BCE). Most previous reports of BCEs are based on manipulations of code compatibility between tasks, while there is no clear picture whether and how mere Task 2 response selection difficulty (in the absence of cross-task dimensional code overlap, including effector system overlap) may also affect Task 1 performance...
June 19, 2018: Acta Psychologica
Zhiwen Wang, Yu Huang, Yuan Li, Bei Wang, Yishan Lu, Liqun Xia, Jufen Tang, JiChang Jian
Nile tilapia (Oreochromis niloticus) is a pivotal economic fish that has been plagued by Streptococcus agalactiae infections for many years. Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a crucial adaptor molecule of the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily, which can trigger downstream signaling cascades involved in innate immunity. In this study, the full-length cDNA of TRAF6 was cloned from O. niloticus (named On-TRAF6), which has an open reading frame of 1716 bp, and encode a polypeptide of 571 amino acids...
June 19, 2018: Fish & Shellfish Immunology
Enrico Miceli, Stefanie Wedepohl, Ernesto Rafael Osorio Blanco, Guido Noé Rimondino, Marisa Martinelli, Miriam Strumia, Maria Molina, Mrityunjoy Kar, Marcelo Calderón
The use of thermoresponsive nanogels (NGs) allows the controlled release of therapeutic molecules upon a thermal switch. Usually, this strategy involves the use of temperature increase to activate cargo expulsion from shrinking NGs. In this study, poly(N-isopropylacrylamide) (pNIPAM)-based NGs were involved in the release of a therapeutic protein corona by temperature decrease. NGs based on dendritic polyglycerol (dPG) and thermoresponsive pNIPAM were semi-interpenetrated with poly(4-acryloylamine-4-(carboxyethyl)heptanodioic acid) (pABC)...
June 19, 2018: European Journal of Pharmaceutics and Biopharmaceutics
I J May-Concha, P G Guerenstein, E A Malo, S Catalá, J C Rojas
Members of the Triatoma dimidiata complex are vectors of the protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease. Morphological and genetic studies indicate that T. dimidiata complex has three principal haplogroups in Mexico. However, whether there are differences in the olfactory physiology among the haplogroups of this complex and a possible correlation with their antennal phenotype are not yet known. Antennal responses to 13 compounds released from the metasternal and Brindley´s glands, which are involved in the alarm and mating-related behaviours of T...
June 19, 2018: Acta Tropica
Melis Karabulutoglu, Rosemary Finnon, Tatsuhiko Imaoka, Anna A Friedl, Christophe Badie
PURPOSE: The review aims to discuss the prominence of dietary and metabolic regulators in maintaining HSC function, long-term self-renewal and differentiation. RESULTS: Most adult stem cells are preserved in a quiescent, non-motile state in vivo which acts as a "protective state" for stem cells to reduce endogenous stress provoked by DNA replication and cellular respiration as well as exogenous environmental stress. The dynamic balance between quiescence, self-renewal and differentiation is critical for supporting a functional blood system throughout life of an organism...
June 22, 2018: International Journal of Radiation Biology
Taylor Howard, Amara Greer-Short, Tony Satroplus, Nehal Patel, Drew Nassal, Peter J Mohler, Thomas J Hund
The mechanisms underlying CaMKII-induced arrhythmias in ischemia/reperfusion (I/R) are not fully understood. In this study, we tested the hypothesis that CaMKII increases late Na+ current (INa,L ) via phosphorylation of Nav 1.5 at Ser571 during I/R, thereby increasing arrhythmia susceptibility. To test our hypothesis, isolated, Langendorff-perfused hearts from wildtype (WT) mice and mice expressing Nav channel variants Nav 1.5-Ser571E (S571E) and Nav 1.5-Ser571A (S571A) were studied. Wildtype (WT) hearts showed a significant increase in the levels of phosphorylated CaMKII and Nav 1...
June 22, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Mohammad Amin Shahrbaf, Mohammad Parsa Mahjoob, Isa Khaheshi, Mohammad Ali Akbarzadeh, Elham Barkhordari, Mohammadreza Naderian, Farbod Zahed Tajrishi
ST-elevation myocardial infarction (STEMI) is one of the potential causes of death worldwide. In spite of substantial advances in its diagnosis and treatment, STEMI is still considered as a major public health dilemma in developed and particularly developing countries. One of the triggering factors of STEMI is supposed to be air pollutants like gaseous pollutants including, sulfur dioxide, nitric dioxide, carbon monoxide, ozone and particulate matters (PM) including, PM under 2.5 µm (PM2.5 ) and PM under 10 µm (PM10 )...
June 22, 2018: Future Cardiology
Sanghita Sengupta, Nathan S Nichols, Adrian Del Maestro, Valeri N Kotov
We investigate wetting phenomena near graphene within the Dzyaloshinskii-Lifshitz-Pitaevskii theory for light gases of hydrogen, helium, and nitrogen in three different geometries where graphene is either affixed to an insulating substrate, submerged or suspended. We find that the presence of graphene has a significant effect in all configurations. When placed on a substrate, the polarizability of graphene can increase the strength of the total van der Waals force by a factor of 2 near the surface, enhancing the propensity towards wetting...
June 8, 2018: Physical Review Letters
Fengmiao Li, George A Sawatzky
The recent observation of replica bands in single-layer FeSe/SrTiO_{3} by angle-resolved photoemission spectroscopy (ARPES) has triggered intense discussions concerning the potential influence of the FeSe electrons coupling with substrate phonons on the superconducting transition temperature. Here we provide strong evidence that the replica bands observed in the single-layer FeSe/SrTiO_{3} system and several other cases are largely due to the energy loss processes of the escaping photoelectron, resulted from the well-known strong coupling of external propagating electrons to Fuchs-Kliewer surface phonons in ionic materials in general...
June 8, 2018: Physical Review Letters
S Fuchs, T Dey, G Aslan-Cansever, A Maljuk, S Wurmehl, B Büchner, V Kataev
We report electron spin resonance (ESR) spectroscopy results on the double perovskite Ba_{2}YIrO_{6}. On general grounds, this material is expected to be nonmagnetic due to the strong coupling of the spin and orbital momenta of Ir^{5+} (5d^{4}) ions. However, controversial experimental reports on either strong antiferromagnetism with static order at low temperatures or just a weakly paramagnetic behavior have triggered a discussion on the breakdown of the generally accepted scenario of the strongly spin-orbit coupled ground states in the 5d^{4} iridates and the emergence of a novel exotic magnetic state...
June 8, 2018: Physical Review Letters
Daniele Mazzarella, Giacomo E M Crisenza, Paolo Melchiorre
Reported herein is a visible-light-mediated organocatalytic direct C-H functionalization of toluene derivatives to afford enantioenriched β-benzylated aldehydes from the corresponding enals. The process combines the oxidative power of a chiral excited-state iminium ion and the basic nature of its counteranion to trigger the generation of benzylic radicals by means of a sequential multisite proton-coupled electron transfer mechanism. This study shows that feedstock chemicals generally used as solvents, such as toluene and xylene derivatives, can be used as substrates for making chiral molecules with high enantioselectivity...
June 22, 2018: Journal of the American Chemical Society
Behnaz Ghaemi, Elnaz Shaabani, Roqya Najafi Taher, Saeedeh Jafari Nodooshan, Amin Sadeghpour, Sharmin Kharrazi, Amir Amani
In this study, we investigated whether ZnO coating on Ag nanoparticles tunes electron flux and hole figuration at Metal-semiconductor interface under UV radiation. This effect triggers photo activity and generation of reactive oxygen species (ROS) from Ag@ZnO nanoparticles which results in enhanced cytotoxic effects and apoptotic cell death in human breast cancer cells (MDA-MB231). In this context, up-regulation of apoptotic cascade proteins (i.e. Bax/Bcl2 association, p53, Cytochrome C and caspase-3) along with activation of oxidative stress proteins suggested occurrence of apoptosis by Ag@ZnO NPs in cancer cells through mitochondrial pathway...
June 22, 2018: ACS Applied Materials & Interfaces
Freda Passam, Joyce Chiu, Lining Ju, Aster Pijning, Zeenat Jahan, Ronit Mor-Cohen, Adva Yeheskel, Katra Kolšek, Lena Thärichen, Camilo Aponte-Santamaría, Frauke Gräter, Philip J Hogg
How proteins harness mechanical force to control function is a significant biological question. Here we describe a human cell surface receptor that couples ligand binding and force to trigger a chemical event which controls the adhesive properties of the receptor. Our studies of the secreted platelet oxidoreductase, ERp5, have revealed that it mediates release of fibrinogen from activated platelet αIIbβ3 integrin. Protein chemical studies show that ligand binding to extended αIIbβ3 integrin renders the βI-domain Cys177-Cys184 disulfide bond cleavable by ERp5...
June 22, 2018: ELife
Tatiana Soboleva, Hector J Esquer, Stacey N Anderson, Lisa M Berreau, Abby D Benninghoff
While interactions between carbon monoxide (CO) and mitochondria have been previously studied, the methods used to deliver CO (gas or CO-releasing metal carbonyl compounds) lack subcellular targeting and/or controlled delivery. Thus, the effective concentration needed to produce changes in mitochondrial bioenergetics is yet to be fully defined. To evaluate the influence of mitochondrial-targeted versus intracellularly-released CO on mitochondrial oxygen consumption rates, we developed and characterized flavonol-based CO donor compounds that differ at their site of release...
June 22, 2018: ACS Chemical Biology
Alann T P Souza, Barbara L S Bezerra, Fabiola S Oliveira, Gileade P Freitas, Rayana L Bighetti Trevisan, Paulo T Oliveira, Adalberto L Rosa, Marcio M Beloti
Among bone morphogenetic proteins (BMPs), BMP-9 has been described as one with higher osteogenic potential. Here, we aimed at evaluating the effect of BMP-9 on the osteoblast differentiation of cells grown on titanium (Ti) with nanotopography, a well-known osseoinductive surface. MC3T3-E1 cells were grown either in absence or presence of BMP-9 (20 nM) on Ti with nanotopography (Ti-Nano) or machined Ti (Ti-Machined) for up to 21 days to evaluate the gene expression of RUNX2, osterix, osteocalcin, bone sialoprotein, SMAD6 and SMAD4, protein expression of SMAD4, ALP activity and extracellular matrix mineralization...
June 22, 2018: Journal of Cellular Biochemistry
Pedro Paulo Gattai, Edgar Maquigussa, Antonio da Silva Novaes, Rosemara da Silva Ribeiro, Vanessa Araújo Varela, Milene Subtil Ormanji, Mirian Aparecida Boim
Acute kidney injury is mostly reversible, and hepatocyte growth factor (HGF) has a relevant role in the tissue repair. MicroRNA (miR)-26a is an endogenous modulator of HGF. The role of miR-26a in the kidney repair process was evaluated in Wistar rats submitted to an acute kidney injury model of rhabdomyolysis induced by glycerol (6 mL/kg). Animals were evaluated 3, 12, 48, 96, and 120 hours after glycerol injection. Serum creatinine (SCr) and gene expression of HGF, c-met, signal transducer and activator of transcription 3 (STAT3), and miR-26a were estimated...
June 22, 2018: Journal of Cellular Biochemistry
Xiangzi Zheng, Nadine Wagener, Hazel McLellan, Petra C Boevink, Chenlei Hua, Paul R J Birch, Frédéric Brunner
Pathogens secrete effector proteins to interfere with plant innate immunity, in which Ca2+ /calmodulin (CaM) signalling plays key roles. Thus far, few effectors have been identified that directly interact with CaM for defence suppression. Here, we report that SFI5, an RXLR effector from Phytophthora infestans, suppresses microbe-associated molecular pattern (MAMP)-triggered immunity (MTI) by interacting with host CaMs. We predicted the CaM-binding site in SFI5 using in silico analysis. The interaction between SFI5 and CaM was tested by both in vitro and in vivo assays...
June 22, 2018: New Phytologist
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