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https://www.readbyqxmd.com/read/28437864/linear-no-threshold-default-assumptions-are-unwarranted-for-cytotoxic-endpoints-independently-triggered-by-ultrasensitive-molecular-switches
#1
Kenneth T Bogen
Crump's response in this issue to my critique of linear-no-threshold (LNT) default assumptions for noncancer and nongenotoxic cancer risks (Risk Analysis 2016; 36(3):589-604) is rebutted herein. Crump maintains that distinguishing between a low-dose linear dose response and a threshold dose response on the basis of dose-response data is impossible even for endpoints involving increased cytotoxicity. My rebuttal relies on descriptions and specific illustrations of two well-characterized ultrasensitive molecular switches that govern two key cytoprotective responses to cellular stress-heat shock response and antioxidant response element activation, respectively-each of which serve to suppress stress-induced apoptotic cell death unless overwhelmed...
April 24, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28437745/comparative-study-of-the-effects-of-gadolinium-chloride-and-gadolinium-based-magnetic-resonance-imaging-contrast-agent-on-freshwater-mussel-dreissena-plymorpha
#2
Houda Hanana, Patrice Turcotte, Chantale André, Christian Gagnon, François Gagné
Gadolinium (Gd), a metal of the lanthanide series used in various industrial and medical purposes is released into the aquatic environment. However, there are few aquatic toxicological studies addressing environmental effects of Gd which remains unknown in aquatic animals. Therefore, this study aimed to compare the effects of GdCl3 and a gadolinium-based MRI contrast agent (Omniscan), in zebra mussels after 28 days through a multibiomarker approach. Data revealed that after GdCl3 exposure, the mRNA level of metallothionein (MT) was modulated, those of cytochrome c oxidase (CO1) and superoxide dismutase (SOD) were increased, while gene expressions of catalase (CAT) and glutathione-S-transferase (GST) were downregulated...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28437626/recent-advances-in-co2-bubble-generating-carrier-systems-for-localized-controlled-release
#3
REVIEW
Yu-Jung Lin, Chieh-Cheng Huang, Wei-Lin Wan, Ching-Hua Chiang, Yen Chang, Hsing-Wen Sung
This article reviews recent progress in the development of carbon dioxide (CO2) bubble-generating drug carriers, including their designs and operating mechanisms; these carriers constitute an advanced class of stimuli-responsive delivery systems with considerable potential. The drug carriers contain stimuli-responsive agents, which are stable before they reach the target location, but enable rapid drug release that is triggered by the generation of CO2 bubbles, which are chemically inert, under certain stimuli...
April 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28437479/conformational-dynamics-of-bacterial-trigger-factor-in-apo-and-ribosome-bound-states
#4
Mehmet Tarik Can, Zeynep Kurkcuoglu, Gokce Ezeroglu, Arzu Uyar, Ozge Kurkcuoglu, Pemra Doruker
The chaperone trigger factor (TF) binds to the ribosome exit tunnel and helps cotranslational folding of nascent chains (NC) in bacterial cells and chloroplasts. In this study, we aim to investigate the functional dynamics of fully-atomistic apo TF and its complex with 50S. As TF accomodates a high percentage of charged residues on its surface, the effect of ionic strength on TF dynamics is assessed here by performing five independent molecular dynamics (MD) simulations (total of 1.3 micro-second duration) at 29 mM and 150 mM ionic strengths...
2017: PloS One
https://www.readbyqxmd.com/read/28437457/tissue-factor-dependent-coagulation-activation-by-heme-a-thromboelastometry-study
#5
Gleice Regina de Souza, Bidossessi Wilfried Hounkpe, Maiara Marx Luz Fiusa, Marina Pereira Colella, Joyce M Annichino-Bizzacchi, Fabiola Traina, Fernando Ferreira Costa, Erich Vinicius De Paula
Heme has been characterized as potent trigger of inflammation. In hemostasis, although heme has been shown to both induce and inhibit different compartments of hemostasis, its net effect on the hemostatic balance, and the biological relevance of these effects remain to be determined. Herein we evaluated the effect of heme on hemostasis using a global assay able to generate clinically relevant data in several other complex hemostatic diseases. Citrated whole blood samples from healthy participants were stimulated by heme or vehicle and incubated for 4h at 37°C...
2017: PloS One
https://www.readbyqxmd.com/read/28437377/microrna-21-is-required-for-local-and-remote-ischemic-preconditioning-in-multiple-organ-protection-against-sepsis
#6
Ping Jia, Xiaoli Wu, Yan Dai, Jie Teng, Yi Fang, Jiachang Hu, Jianzhou Zou, Mingyu Liang, Xiaoqiang Ding
OBJECTIVE: Sepsis, triggered by microbial infection, is a common and life-threatening systemic illness, often leads to impaired function of vital organs. Ischemic preconditioning induced by transient brief episodes of ischemia is a powerful innate mechanism of organ protection. We have reported that a 15-minute renal ischemic preconditioning substantially attenuated subsequent renal ischemia-reperfusion injury. Here, we investigate whether a brief ischemia and reperfusion in kidney can provide protection at local and remote sites against sepsis-induced organ injury, and whether this protection is microRNA-21 dependent...
April 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28437066/electric-field-driven-direct-desulfurization
#7
Bogdana Borca, Tomasz Michnowicz, Rémi Pétuya, Marcel Pristl, Verena Schendel, Ivan Pentegov, Ulrike Kraft, Hagen Klauk, Peter Wahl, Rico Gutzler, Andrés Arnau, Uta Schlickum, Klaus Kern
The ability to elucidate the elementary steps of a chemical reaction at the atomic scale is important for the detailed understanding of the processes involved which is key to uncover avenues for improved reaction paths. Here, we track the chemical pathway of an irreversible direct desulfurization reaction of tetracenothiophene adsorbed on the Cu(111) closed-packed surface at the submolecular level. Using the precise control of the tip position in a Scanning Tunneling Microscope and the electric field applied across the tunnel junction, the two carbon-sulfur bonds of a thiophene unit are successively cleaved...
April 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28437039/uterine-artery-pseudoaneurysm-bleeding-one-decade-after-caesarean-section-a-case-report
#8
Liza Johannesson, Jennifer Mason, Martin K Oehler
Uterine artery pseudoaneurysm (UAP) can cause severe secondary post-partum hemorrhage. The lag time between the triggering event and the manifestation of UAP reportedly usually occurs within a couple of weeks. In this case report, a 46-year-old woman with no significant comorbidities presented with a one-month history of increasing lower abdominal pain. She had previously undergone two cesarean sections (14 and 10 years earlier). A computed tomography angiogram revealed a left UAP. The patient was successfully treated by selective embolization and had an uneventful recovery...
April 24, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28437016/electromechanical-nanogenerator-cell-interaction-modulates-cell-activity
#9
Gonzalo Murillo, Andreu Blanquer, Carolina Vargas-Estevez, Lleonard Barrios, Elena Ibáñez, Carme Nogués, Jaume Esteve
Noninvasive methods for in situ electrical stimulation of human cells open new frontiers to future bioelectronic therapies, where controlled electrical impulses could replace the use of chemical drugs for disease treatment. Here, this study demonstrates that the interaction of living cells with piezoelectric nanogenerators (NGs) induces a local electric field that self-stimulates and modulates their cell activity, without applying an additional chemical or physical external stimulation. When cells are cultured on top of the NGs, based on 2D ZnO nanosheets, the electromechanical NG-cell interactions stimulate the motility of macrophages and trigger the opening of ion channels present in the plasma membrane of osteoblast-like cells (Saos-2) inducing intracellular calcium transients...
April 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28436959/peptide-mhc-based-nanomedicines-for-autoimmunity-function-as-t-cell-receptor-microclustering-devices
#10
Santiswarup Singha, Kun Shao, Yang Yang, Xavier Clemente-Casares, Patricia Solé, Antonio Clemente, Jesús Blanco, Qin Dai, Fayi Song, Shang Wan Liu, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Roopa Hebbandi Nanjundappa, Pascal Detampel, Matthias Amrein, César Fandos, Robert Tanguay, Susan Newbigging, Pau Serra, Anmar Khadra, Warren C W Chan, Pere Santamaria
We have shown that nanoparticles (NPs) can be used as ligand-multimerization platforms to activate specific cellular receptors in vivo. Nanoparticles coated with autoimmune disease-relevant peptide-major histocompatibility complexes (pMHC) blunted autoimmune responses by triggering the differentiation and expansion of antigen-specific regulatory T cells in vivo. Here, we define the engineering principles impacting biological activity, detail a synthesis process yielding safe and stable compounds, and visualize how these nanomedicines interact with cognate T cells...
April 24, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28436935/tnf-superfamily-receptor-ox40-triggers-invariant-nkt-cell-pyroptosis-and-liver-injury
#11
Peixiang Lan, Yihui Fan, Yue Zhao, Xiaohua Lou, Howard P Monsour, Xiaolong Zhang, Yongwon Choi, Yaling Dou, Naoto Ishii, Rafik M Ghobrial, Xiang Xiao, Xian Chang Li
Tissue-resident immune cells play a key role in local and systemic immune responses. The liver, in particular, hosts a large number of invariant natural killer T (iNKT) cells, which are involved in diverse immune responses. However, the mechanisms that regulate survival and homeostasis of liver iNKT cells are poorly defined. Here we have found that liver iNKT cells constitutively express the costimulatory TNF superfamily receptor OX40 and that OX40 stimulation results in massive pyroptotic death of iNKT cells, characterized by the release of potent proinflammatory cytokines that induce liver injury...
April 24, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28436918/an-integrated-and-highly-sensitive-ultrafast-acoustoelectric-imaging-system-for-biomedical-applications
#12
Beatrice Berthon, Pierre-Marc Dansette, Mickael Tanter, Mathieu Pernot, Jean Provost
PURPOSE: Direct imaging of cardiac electrical activation is crucial to better understand and diagnose diseases linked to arrhythmias. This work presents an Ultrafast Acoustoelectric Imaging (UAI) system for direct and non-invasive ultrafast mapping of propagating current densities. MATERIALS AND METHODS: Acoustoelectric imaging is based on the acoustoelectric effect, the modulation of the medium's electrical impedance by a propagating ultrasonic wave. UAI triggers this effect with plane wave emissions to image current densities...
April 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28436718/design-of-a-novel-curcumin-soybean-phosphatidylcholine-complex-based-targeted-drug-delivery-systems
#13
Jiajiang Xie, Yanxiu Li, Liang Song, Zhou Pan, Shefang Ye, Zhenqing Hou
Recently, the global trend in the field of nanomedicine has been toward the design of combination of nature active constituents and phospholipid (PC) to form a therapeutic drug-phospholipid complex. As a particular amphiphilic molecular complex, it can be a unique bridge of traditional dosage-form and novel drug delivery system. In thisarticle, on the basis of drug-phospholipid complex technique and self-assembly technique, we chose a pharmacologically safe and low toxic drug curcumin (CUR) to increase drug-loading ability, achieve controlled/sustained drug release and improve anticancer activity...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28436713/modified-dextran-heparin-based-triggered-release-microspheres-for-cardiovascular-delivery-of-therapeutic-drugs-using-protamine-as-a-stimulus
#14
Hoai X Nguyen, Edgar A O'Rear
In this study, we describe the synthesis of an amine-modified acetalated dextran polymer which is combined with heparin (HP) as the basis for a novel controlled release system. Dextran-amine (DEXAM) conjugates, synthesized using reductive amination, were incorporated into DEXAM/HP microspheres. HP binds to positively charged ammonium ions of the DEXAM conjugates, contributing to the structural integrity of the microspheres. Crystal violet (CV) was encapsulated inside DEXAM/HP microspheres as a model drug to test the system...
April 24, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28436652/observation-of-the-generation-of-onoo-in-mitochondria-under-various-stimuli-with-a-sensitive-fluorescence-probe
#15
Hongyu Li, Xiaohua Li, Xiaofeng Wu, Wen Shi, Huimin Ma
Peroxynitrite (ONOO-), an important reactive oxygen species (ROS), may be generated in the mitochondria under various physiological and pathological conditions. In this work, we designed and synthesized a mitochondria-targetable fluorescence probe RPTPP by using rhodamine as the fluorophore, phenylhydrazine as the recognition moiety, and triphenyl- phosphonium cation as the mitochondria-targeting moiety. Upon reaction of the probe with ONOO-, the oxidation of phenylhydrazine by ONOO- and the subsequent hydrolysis opens the non-fluorescent spirocyclic structure and thus triggers a fluorescence turn-on response, which provides a sensitive and selective method for the detection of ONOO-...
April 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28436525/graphitic-c3n4-nanosheets-synergistic-effects-of-hydrogenation-and-n-n-junctions-for-enhanced-photocatalytic-activities
#16
Minjie Zhou, Zhaohui Hou, Xiaobo Chen
The increasing concern about environmental pollution and fossil fuel energies have urged researchers to seek renewable energy sources and methods for pollutant decomposition. Photocatalysis seems to be one of the most promising approaches, which uses natural sunlight to produce hydrogen from water and removes organic pollutants from the environment. Among the various photocatalysts, graphitic carbon nitride (g-C3N4) has recently attracted much attention as a metal-free photocatalyst; however, it did not give a satisfactory performance...
April 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28436509/covering-the-optical-spectrum-through-collective-rare-earth-doping-of-nagdf4-nanoparticles-806-and-980-nm-excitation-routes
#17
A Skripka, R Marin, A Benayas, P Canton, E Hemmer, F Vetrone
Today, at the frontier of biomedical research, the need has been clearly established for integrating disease detection and therapeutic function in one single theranostic system. Light-emitting nanoparticles are being intensively investigated to fulfil this demand, by continuously developing nanoparticle systems simultaneously emitting in both the UV/visible (light-triggered release and activation of drugs) and the near-infrared (imaging and tracking) spectral regions. In this work, rare-earth (RE) doped nanoparticles (RENPs) were synthesized via a thermal decomposition process and spectroscopically investigated as potential candidates as all-in-one optical imaging, diagnostic and therapeutic agents...
April 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28436491/extratropical-forcing-triggered-the-2015-madden-julian-oscillation-el-ni%C3%A3-o-event
#18
Chi-Cherng Hong, Huang-Hsiung Hsu, Wan-Ling Tseng, Ming-Ying Lee, Chun-Hoe Chow, Li-Chiang Jiang
In this paper, we report the triggering effect of extratropical perturbation on the onset of an atypical Madden-Julian Oscillation (MJO) and onset of the 2015-16 El Niño in March 2015. The MJO exhibited several unique characteristics: the effect of extratropical forcing, atypical genesis location and timing in the equatorial western Pacific, and the extremity of amplitudes in many aspects. The southward-penetrating northerly associated with the extratropical disturbances in the extratropical western North Pacific contributed to triggering the deep convection and westerly wind burst (WWB) and onset of the MJO over the anomalously warm tropical western Pacific in early March...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28436457/fasciola-hepatica-glycoconjugates-immuneregulate-dendritic-cells-through-the-dendritic-cell-specific-intercellular-adhesion-molecule-3-grabbing-non-integrin-inducing-t-cell-anergy
#19
Ernesto Rodríguez, Hakan Kalay, Verónica Noya, Natalie Brossard, Cecilia Giacomini, Yvette van Kooyk, Juan J García-Vallejo, Teresa Freire
Dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN) expressed on a variety of DCs, is a C-type lectin receptor that recognizes glycans on a diverse range of pathogens, including parasites. The interaction of DC-SIGN with pathogens triggers specific signaling events that modulate DC-maturation and activity and regulate T-cell activation by DCs. In this work we evaluate whether F. hepatica glycans can immune modulate DCs via DC-SIGN. We demonstrate that DC-SIGN interacts with F. hepatica glycoconjugates through mannose and fucose residues...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28436448/elevated-circulating-levels-of-the-interferon-%C3%AE-induced-chemokines-are-associated-with-disease-activity-and-cutaneous-manifestations-in-adult-onset-still-s-disease
#20
Jae Ho Han, Chang-Hee Suh, Ju-Yang Jung, Mi-Hyun Ahn, Mi Hwa Han, Ji Eun Kwon, Hyunee Yim, Hyoun-Ah Kim
C-X-C motif chemokine 9 (CXCL9), CXCL10, and CXCL11 are produced in response to interferon-γ (IFN-γ) and trigger inflammation with the accumulation of activated lymphocytes. It appears that these chemokines could play a role in the pathogenesis of adult-onset Still's disease (AOSD). Therefore, we investigated the associations between the levels of these chemokine and clinical manifestations in patients with active AOSD. Serum levels of IFN-γ, CXCL9, CXCL10 and CXCL11 were determined using enzyme-linked immunosorbent assays...
April 24, 2017: Scientific Reports
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