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radiation proctitis

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https://www.readbyqxmd.com/read/27816539/feasibility-study-of-toxicity-outcomes-using-gec-estro-contouring-guidelines-on-ct-based-instead-of-mri-based-planning-in-locally-advanced-cervical-cancer-patients
#1
Vicky Koh, Bok Ai Choo, Khai Mun Lee, Teng Hwee Tan, Jen Hui Jeffrey Low, Soon Yau Joseph Ng, Arunachalam Ilancheran, Liang Shen, Johann Tang
PURPOSE: To report late rectal and bladder toxicity outcomes of a CT-based image-guided brachytherapy (IGBT) technique for treatment of cervical cancer. METHODS AND MATERIALS: Between 2008 and 2014, 95 women with International Federation of Gynecology and Obstetrics stage IB to IVA cervical carcinoma treated with definitive concurrent cisplatin-based chemotherapy and external beam radiation therapy 50.4 Gy in 28 fractions followed by planned prescription dose of 7 Gy × 4 fractions of high-dose-rate IGBT was retrospectively reviewed...
November 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27807581/pouchitis-associated-with-pelvic-radiation-for-prostate-cancer
#2
Geeta Kulkarni, Xiuli Liu, Bo Shen
Radiation therapy is a viable option in managing potentially life-threatening malignancies including prostate cancer. It is known that pelvic radiation can result in injury of the distal large bowel with the development of radiation proctitis. Despite reports from retrospective studies, there is a lack of direct endoscopic and histologic evidence of external pelvic radiation injury to the ileal pouch-anal anastomosis. We present a case of a 68-year-old male with pouchitis resulting from pelvic radiation for prostate cancer...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27681755/simultaneous-integrated-boost-volumetric-modulated-arc-therapy-in-the-postoperative-treatment-of-high-risk-to-intermediate-risk-endometrial-cancer-results-of-ada-ii-phase-1-2-trial
#3
Gabriella Macchia, Savino Cilla, Francesco Deodato, Anna Ianiro, Francesco Legge, Martina Marucci, Silvia Cammelli, Anna Myriam Perrone, Pierandrea De Iaco, Maria Antonietta Gambacorta, Rosa Autorino, Vincenzo Valentini, Alessio G Morganti, Gabriella Ferrandina
PURPOSE: A prospective phase 1-2 clinical trial aimed at determining the recommended postoperative dose of simultaneous integrated boost volumetric modulated arc therapy (SIB-VMAT) in a large series of patients with high-risk and intermediate-risk endometrial cancer (HIR-EC) is presented. The study also evaluated the association between rate and severity of toxicity and comorbidities and the clinical outcomes. METHODS AND MATERIALS: Two SIB-VMAT dose levels were investigated for boost to the vaginal vault, whereas the pelvic lymph nodes were always treated with 45 Gy...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674005/endorectal-epinephrine-suspension-may-protect-against-radiation-proctitis-during-radiation-therapy-for-pelvic-tumor
#4
S Qin, X S Gao, H Z Li, C X Liu, D L Hou, W D Nian, X Y Li
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27663931/long-term-results-on-the-efficacy-of-argon-plasma-coagulation-for-patients-with-chronic-radiation-proctitis-after-conventionally-fractionated-dose-escalated-radiation-therapy-for-prostate-cancer
#5
Joseph Weiner, David Schwartz, Manuel Martinez, Joseph Safdieh, Ayse Aytaman, David Schreiber
PURPOSE: This study was designed to assess the efficacy and outcomes of argon plasma coagulation (APC) in the management of chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy (≥7560 cGy). METHODS AND MATERIALS: We retrospectively reviewed the charts on all patients treated with external beam radiation therapy (minimum dose, 7560 cGy) for histologically confirmed prostate cancer at our institution from 2003 to 2011. Five hundred patients met these criteria; of these, 35 patients (7...
August 1, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27644912/management-of-radiation-and-chemotherapy-related-acute-toxicity-in-gastrointestinal-cancer
#6
REVIEW
Gerhard G Grabenbauer, Göbel Holger
Possible toxic effects following radiation and chemotherapy of gastrointestinal tumours may cause a depletion of the mucosal barrier within the radiation volumes with severe mucositis. Diarrhoea, nausea, emesis and severe malabsorption followed by infections with dehydration and electrolyte disorders have to be encountered. For prevention and treatment of oropharyngeal mucositis an oral care protocol, oral cryotherapy together with benzydamine mouthwash may be recommended. Lower gastrointestinal diarrhoea is best treated by Octreotide (>100 μg s...
August 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27631775/acute-adverse-events-and-postoperative-complications-in-a-randomized-trial-of-preoperative-short-course-radiotherapy-versus-long-course-chemoradiotherapy-for-t3-adenocarcinoma-of-the-rectum-trans-tasman-radiation-oncology-group-trial-trog-01-04
#7
Nabila Ansari, Michael J Solomon, Richard J Fisher, John Mackay, Bryan Burmeister, Stephen Ackland, Alexander Heriot, David Joseph, Sue-Anne McLachlan, Bev McClure, Samuel Y Ngan
OBJECTIVE: To compare acute adverse events (AE) and postoperative complication rates in a randomized trial of short-course (SC) versus long-course (LC) preoperative radiotherapy. BACKGROUND: Evidence demonstrates that adding neoadjuvant radiotherapy to surgery offers better local control in the management of rectal cancer. With both SC and LC therapy there is a potential for acute treatment-related toxicity and increased patient morbidity. METHODS: Eligible patients had clinical-stage T3 rectal adenocarcinoma within 12 cm of the anal verge with no evidence of metastasis...
September 14, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27613188/severe-weight-loss-during-preoperative-chemoradiotherapy-compromises-survival-outcome-for-patients-with-locally-advanced-rectal-cancer
#8
Junzhong Lin, Jianhong Peng, Aiham Qdaisat, Liren Li, Gong Chen, Zhenhai Lu, Xiaojun Wu, Yuanhong Gao, Zhifan Zeng, Peirong Ding, Zhizhong Pan
PURPOSE: In addition to tumor factors, poor nutritional status before and during anti-tumor treatment might compromise prognosis in several types of cancer. This study was done to determine the impact of weight loss during preoperative chemoradiotherapy (CRT) on the survival outcome of patients with locally advanced rectal cancer (LARC). METHODS: The retrospective study examined consecutive patients with LARC who underwent preoperative CRT followed by radical resection in a single institute, between 2003 and 2013...
December 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27610010/endoscopic-and-non-endoscopic-approaches-for-the-management-of-radiation-induced-rectal-bleeding
#9
REVIEW
Joseph Paul Weiner, Andrew Thomas Wong, David Schwartz, Manuel Martinez, Ayse Aytaman, David Schreiber
Pelvic radiation is a commonly utilized treatment for malignancy of the genitourinary and lower gastrointestinal tract. Radiation proctitis and the resultant clinical picture varies from asymptomatic to potentially life threatening. Similarly, treatment options also vary greatly, from medical therapy to surgical intervention. Commonly utilized medical therapy includes sucralfate enemas, antibiotics, 5-aminosalicylic acid derivatives, probiotics, antioxidants, short-chain fatty acids, formalin instillation and fractionated hyperbaric oxygen...
August 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27602924/impact-of-preoperative-radiotherapy-on-anastomotic-leakage-and-stenosis-after-rectal-cancer-resection-post-hoc-analysis-of-a-randomized-controlled-trial
#10
Qiyuan Qin, Tenghui Ma, Yanhong Deng, Jian Zheng, Zhiyang Zhou, Hui Wang, Lei Wang, Jianping Wang
BACKGROUND: Evidence regarding the effect of preoperative radiotherapy on anastomotic integrity remains conflicting in rectal cancer surgery. Prospective comparisons with appropriate controls are needed. OBJECTIVE: This study aimed to assess the impact of preoperative radiotherapy on anastomotic leakage and stenosis after rectal cancer resection. DESIGN: This was a post hoc analysis of a randomized controlled trial (NCT01211210). SETTINGS: Data were retrieved from the leading center of the trial, which is a tertiary hospital...
October 2016: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27527929/complication-and-remission-rates-after-endoscopic-argon-plasma-coagulation-in-the-treatment-of-haemorrhagic-radiation-proctitis
#11
S L Siow, H A Mahendran, C J Seo
PURPOSE: The management of haemorrhagic radiation proctitis is challenging because of the necessity for repeated intervention. The efficacy of argon plasma coagulation has been described before but the optimum treatment strategy remains debatable. This is a review of our experience over a decade treating patients with haemorrhagic radiation proctitis and their follow-up. METHODS: This is a retrospective review of consecutive patients who underwent argon plasma coagulation for haemorrhagic radiation proctitis between January 2003 and December 2013...
August 15, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27504391/exploring-the-management-of-radiation-proctitis-in-current-clinical-practice
#12
REVIEW
Nupur Bansal, Abhishek Soni, Paramjeet Kaur, Ashok Kumar Chauhan, Vivek Kaushal
INTRODUCTION: Radiation proctitis is radiation induced rectal mucositis, occurring as a consequence to radiation therapy of the pelvic organs for various pelvic region malignancies. The management of radiation proctitis is extremely challenging as no recommended guidelines are available and limited number of studies are there in the literature involving the various treatment options. AIM: The aim of the study is the in-depth review of published literature to see the role of various treatment modalities in the management of radiation proctitis...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27489794/proctitis-1-week-after-stereotactic-body-radiation-therapy-for-prostate-cancer-implications-for-clinical-trial-design
#13
Ima Paydar, Robyn A Cyr, Thomas M Yung, Siyuan Lei, Brian Timothy Collins, Leonard N Chen, Simeng Suy, Anatoly Dritschilo, John H Lynch, Sean P Collins
BACKGROUND: Proctitis following prostate cancer radiation therapy is a primary determinant of quality of life (QOL). While previous studies have assessed acute rectal morbidity at 1 month after stereotactic body radiotherapy (SBRT), little data exist on the prevalence and severity of rectal morbidity within the first week following treatment. This study reports the acute bowel morbidity 1 week following prostate SBRT. MATERIALS AND METHODS: Between May 2013 and August 2014, 103 patients with clinically localized prostate cancer were treated with 35-36...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27462390/chronic-haemorrhagic-radiation-proctitis-a-review
#14
REVIEW
Vishnu Prasad Nelamangala Ramakrishnaiah, Srinivasan Krishnamachari
Chronic haemorrhagic radiation proctitis (CHRP) is a difficult problem faced by the patients following radiation for pelvic malignancy. There is no standard treatment for this condition, but many methods of treatment are available. The aim of this study was to review the literature to see whether there is an improvement in the available evidence in comparison with previously published systematic reviews in treating patients with CHRP. The PubMed/Medline database and Google Scholar search was selectively searched...
July 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27448578/microbiota-metabolite-short-chain-fatty-acids-gpcr-and-inflammatory-bowel-diseases
#15
Mingming Sun, Wei Wu, Zhanju Liu, Yingzi Cong
Gut microbiota has been well recognized in regulation of intestinal homeostasis and pathogenesis of inflammatory bowel diseases. However, the mechanisms involved are still not completely understood. Further, the components of the microbiota which are critically responsible for such effects are also largely unknown. Accumulating evidence suggests that, in addition to pathogen-associated molecular patterns, nutrition and bacterial metabolites might greatly impact the immune response in the gut and beyond. Short chain fatty acids (SCFA), which are metabolized by gut bacteria from otherwise indigestible fiber-rich diets, have been shown to ameliorate diseases in animal models of inflammatory bowel diseases (IBD) and allergic asthma...
July 23, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27416796/impact-of-treatment-time-related-factors-on-prognoses-and-radiation-proctitis-after-definitive-chemoradiotherapy-for-cervical-cancer
#16
Eng-Yen Huang, Hao Lin, Chong-Jong Wang, Chan-Chao Chanchien, Yu-Che Ou
This study aimed to investigate the impact of treatment time-related factors on outcomes and radiation proctitis in patients undergoing concurrent chemoradiotherapy (CCRT) for cervical cancer. From September 2001 to December 2012, 146 patients with stage IIB cervical squamous cell carcinoma treated with CCRT were reviewed from a prospective cohort. Patients who received the same dose (45 Gy) of external beam radiation therapy (EBRT) were included in the analysis (n = 125). The same equivalent dose of 2 Gy (EQD2) of high-dose-rate intracavitary brachytherapy (HDR-ICBT) was delivered at either 4 fractions of 6 Gy or 6 fractions of 4...
September 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27389021/high-quality-linac-based-stereotactic-body-radiation-therapy-with-flattening-filter-free-beams-and-volumetric-modulated-arc-therapy-for-low-intermediate-risk-prostate-cancer-a-mono-institutional-experience-with-90-patients
#17
G D'Agostino, C Franzese, F De Rose, D Franceschini, T Comito, E Villa, F Alongi, R Liardo, S Tomatis, P Navarria, P Mancosu, G Reggiori, L Cozzi, M Scorsetti
AIMS: The aim of this phase II study was to evaluate the efficacy and toxicity of stereotactic body radiotherapy in patients with low or intermediate risk prostate cancer. MATERIALS AND METHODS: Biopsy-confirmed prostate cancer patients were enrolled, provided that they had the following characteristics: initial prostate-specific antigen (PSA) ≤ 20 ng/ml, Gleason Score < 7, International Prostate Symptom Score < 7. The treatment schedule was 35 Gy in five fractions, delivered with volumetric modulated arcs with flattening filter free beams...
July 4, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27387204/chemotherapy-versus-radiotherapy-for-figo-stages-ib1-and-iia1-cervical-carcinoma-patients-with-postoperative-isolated-deep-stromal-invasion-a-retrospective-study
#18
Lei Li, XiaoYan Song, RuoNan Liu, Nan Li, Ye Zhang, Yan Cheng, HongTu Chao, LiYing Wang
BACKGROUND: The adjuvant treatment for patients with isolated stromal invasion after radical hysterectomy and pelvic lymph node dissection (PLND) in FIGO stage IB1 and IIA1 cervical carcinoma has not been established. This study assessed the survival outcomes and recurrent patterns in this particular group of patients treated with chemotherapy or radiation-based adjuvant therapy. METHODS: The records 133 IB1 and IIA1 postoperative cervical carcinoma patients with histopathology-confirmed isolated deep stromal invasion (DSI) without any other unfavorable pathological finding between June 2010 and March 2013 were analyzed...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27350738/colostomy-is-a-simple-and-effective-procedure-for-severe-chronic-radiation-proctitis
#19
Zi-Xu Yuan, Teng-Hui Ma, Huai-Ming Wang, Qing-Hua Zhong, Xi-Hu Yu, Qi-Yuan Qin, Jian-Ping Wang, Lei Wang
AIM: To assess the efficacy and safety of diverting colostomy in treating severe hemorrhagic chronic radiation proctitis (CRP). METHODS: Patients with severe hemorrhagic CRP who were admitted from 2008 to 2014 were enrolled into this study. All CRP patients were diagnosed by a combination of pelvic radiation history, clinical rectal bleeding, and endoscopic findings. Inclusion criteria were CRP patients with refractory bleeding with moderate to severe anemia with a hemoglobin level < 90 g/L...
June 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27342943/-hyperbaric-oxygen-and-radiotherapy-from-myth-to-reality
#20
S Espenel, C Raffoux, A Vallard, M-A Garcia, J-B Guy, C Rancoule, M Ben Mrad, J Langrand-Escure, J-C Trone, G Pigne, P Diao, N Magné
Worldwide, more than a million people receive each year a curative radiotherapy. While local control and overall survival are steadily increasing, 5 to 15% of patients still develop above grade 2 late toxicities. Late toxicities treatments are complex. Hyperbaric oxygenation was shown to induce revascularization and healing of injured tissues, but indications are still debated. Through a literature review, we summarized the hyperbaric oxygenation indications in radiation-induced late toxicities. We also studied the knowledge and practice of French local radiation therapists...
July 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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