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https://www.readbyqxmd.com/read/28214483/systemic-thrombolysis-increases-hemorrhagic-stroke-risk-without-survival-benefit-compared-with-catheter-directed-intervention-for-the-treatment-of-acute-pulmonary-embolism
#1
Nathan L Liang, Efthymios D Avgerinos, Michael J Singh, Michel S Makaroun, Rabih A Chaer
BACKGROUND: Systemic thrombolysis (ST) and catheter-directed intervention (CDI) are both used in the treatment of acute pulmonary embolism (PE), but the comparative outcomes of these two therapies remain unclear. The objective of this study was to compare short-term mortality and safety outcomes between the two treatments using a large national database. METHODS: Patients presenting with acute PE were identified in the National Inpatient Sample (NIS) from 2009 to 2012...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28212532/long-non-coding-rna-ptenp1-functions-as-a-cerna-to-modulate-pten-level-by-decoying-mir-106b-and-mir-93-in-gastric-cancer
#2
Rupeng Zhang, Yuenan Guo, Zhenchi Ma, Gang Ma, Qiang Xue, Fangxuan Li, Liren Liu
Recent studies have shown that competing endogenous RNAs (ceRNAs) play an important role in the regulation of gene expression, and participate in a wide range of biological processes, including carcinogenesis. Long non-coding RNA PTENP1, the pseudogene of PTEN tumor suppressor, has been reported to exert its tumor suppressive function via modulation of PTEN expression in many malignancies. However, whether a PTENP1~miRNA~PTEN ceRNA network exists and how it functions in gastric cancer (GC) remains elusive. In order to identify and characterize the PTENP1~miRNA~PTEN ceRNA network in GC, we first determined PTENP1 levels in clinical GC samples and found that PTENP1 and PTEN were concurrently downregulated in these samples...
February 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28199740/incidence-of-abnormal-liver-biochemical-tests-in-hyperthyroidism
#3
Tiffany Y Lin, Anshula O Shekar, Ning Li, Michael W Yeh, Sammy Saab, Mark Wilson, Angela M Leung
OBJECTIVE: Abnormal serum liver function tests are common in patients with untreated thyrotoxicosis, even prior to the initiation of antithyroidal medications that may worsen their severity. There is a wide range of the incidence of these abnormalities in the published literature. The aim of this study was to assess the risks factors and threshold of thyrotoxicosis severity for developing an abnormal liver biochemical test upon the diagnosis of new thyrotoxicosis. DESIGN: Single-institution retrospective cohort study...
February 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28187423/integrated-automatic-workflow-for-phylogenetic-tree-analysis-using-public-access-and-local-web-services
#4
Kasikrit Damkliang, Pichaya Tandayya, Unitsa Sangket, Ekawat Pasomsub
At the present, coding sequence (CDS) has been discovered and larger CDS is being revealed frequently. Approaches and related tools have also been developed and upgraded concurrently, especially for phylogenetic tree analysis. This paper proposes an integrated automatic Taverna workflow for the phylogenetic tree inferring analysis using public access web services at European Bioinformatics Institute (EMBL-EBI) and Swiss Institute of Bioinformatics (SIB), and our own deployed local web services. The workflow input is a set of CDS in the Fasta format...
November 28, 2016: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/28167674/ventrolateral-striatal-medium-spiny-neurons-positively-regulate-food-incentive-goal-directed-behavior-independently-of-d1-and-d2-selectivity
#5
Akiyo Natsubori, Iku Tsustui-Kimura, Hiroshi Nishida, Youcef Bouchekioua, Hiroshi Sekiya, Motokazu Uchigashima, Masahiko Watanabe, Alban de Kerchove d'Exaerde, Masaru Mimura, Norio Takata, Kenji F Tanaka
: The ventral striatum is involved in motivated behavior. Akin to the dorsal striatum, the ventral striatum contains two parallel pathways: the striatomesencephalic pathway consisting of dopamine receptor type 1-expressing medium spiny neurons (D1-MSNs) and the striatopallidal pathway consisting of D2-MSNs. These two genetically identified pathways are thought to encode opposing functions in motivated behavior. It has also been reported that D1/D2 genetic selectivity is not attributed to the anatomical discrimination of two pathways...
February 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28161033/hepatitis-c-antibody-testing-in-a-commercially-insured-population-2005-2014
#6
Cheryl J Isenhour, Susan H Hariri, Craig M Hales, Claudia J Vellozzi
INTRODUCTION: In the U.S., the burden of hepatitis C virus (HCV) infection and associated sequelae is substantial. HCV prevalence is highest among those born in 1945-1965 (Birth Cohort). Newly diagnosed infections are increasing in younger people concurrent with rising opioid/heroin use. The Centers for Disease Control and Prevention (2012) and U.S. Preventive Services Task Force (2013) recommend HCV testing for at-risk individuals and one-time testing for the Birth Cohort. This study describes national trends in HCV antibody testing from 2005 to 2014...
February 1, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28158992/patients-anticipated-actions-following-transient-ischaemic-attack-symptoms-a-qualitative-vignette-based-study
#7
Parker Magin, Terry Joyce, Christopher Levi, Daniel Lasserson
BACKGROUND: Transient Ischaemic Attack (TIA) requires urgent investigation and management. Urgent management reduces the risk of subsequent stroke markedly, but non-presentation or delays in patient presentation to health services have been found to compromise timely management. We aimed to explore general practice patients' anticipated responses to TIA symptoms. METHODS: This was a qualitative study employing semi-structured telephone interviews. Participants were recruited from respondents in an earlier quantitative study based in Australian general practices...
February 3, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28152778/patterns-of-comorbidity-among-older-u-s-patients-with-non-hodgkin-lymphoma
#8
Steven I Park, Jennifer Leigh Lund
: 304 Background: Evidence suggests that the number and type ofcomorbidities at cancer diagnosis influences cancer treatment and mortality, especially among older patients.We sought to describe comorbidity patterns and identify how patterns predict all-cause mortality among older non-Hodgkin lymphoma (NHL) patients. METHODS: Using the linked Surveillance, Epidemiologic, and End Results (SEER)-Medicare databases, we identified patients aged > 66 with a first diagnosis of stage I-IV NHL from 2007-2009...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28143429/celiac-disease-and-down-syndrome-mortality-a-nationwide-cohort-study
#9
Jonas F Ludvigsson, Benjamin Lebwohl, Peter H R Green, Wendy K Chung, Karl Mårild
BACKGROUND: Individuals with Down syndrome (DS) have increased mortality and are also at increased risk of celiac disease (CD). It is unknown if CD influences mortality in DS. In this study we examined the risk of death in individuals with DS according to celiac status. METHODS: In this nationwide population-based cohort study, we first identified individuals with CD (diagnosed 1969-2008) through small intestinal biopsy report data showing villous atrophy (Marsh stage III) from Sweden's 28 pathology departments...
January 31, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28135194/validation-of-a-novel-claims-based-stroke-severity-index-in-patients-with-intracerebral-hemorrhage
#10
Ling-Chien Hung, Sheng-Feng Sung, Cheng-Yang Hsieh, Ya-Han Hu, Huey-Juan Lin, Yu-Wei Chen, Yea-Huei Kao Yang, Sue-Jane Lin
BACKGROUND: Stroke severity is an important outcome predictor for intracerebral hemorrhage (ICH) but is typically unavailable in administrative claims data. We validated a claims-based stroke severity index (SSI) in patients with ICH in Taiwan. METHODS: Consecutive ICH patients from hospital-based stroke registries were linked with a nationwide claims database. Stroke severity, assessed using the National Institutes of Health Stroke Scale (NIHSS), and functional outcomes, assessed using the modified Rankin Scale (mRS), were obtained from the registries...
January 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28133951/cost-effective-approach-to-the-diagnostic-workup-of-b-cell-lymphoproliferative-disorders-via-optimal-integration-of-flow-cytometric-data
#11
E F Mason, E A Morgan, G S Pinkus, O Pozdnyakova
INTRODUCTION: The workup of lymphoproliferative disorders (LPDs) involves the combined use of flow cytometry (FC) and immunohistochemistry (IHC). This often results in duplicate immunophenotypic testing and adds costs that may not be eligible for reimbursement based on the Medicare National Correct Coding Initiative. We aimed to establish a cost-effective diagnostic algorithm based on initial FC categorization to reduce repetitive immunophenotyping. METHODS: We retrospectively reviewed 242 cases of suspected LPDs with concurrent FC and IHC testing over a 12-month period...
January 30, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28120509/profile-of-hospital-admissions-due-to-self-inflicted-harm-in-los-angeles-county-from-2001-to-2010
#12
Shahrzad Bazargan-Hejazi, Alireza Ahmadi, Mohsen Bazargan, Elham Rahmani, Deyu Pan, Golara Zahmatkesh, Stacey Teruya
We aimed to describe the demographic profile of self-inflicted harm (SIH) in Los Angeles County between 2001 and 2010 and to investigate trends over this 10-year period. We used the California Hospital Discharge Data to investigate all cases of hospital admission due to SIH, including suicide attempts and if they had a concurrent psychiatric diagnosis based on ICD-9 codes. African-Americans (AA) had the highest 10-year SIH admission rates. SIH admission rates remained steady throughout the 10-year study period...
January 25, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28116102/self-determined-motivation-in-rehabilitating-professional-rugby-union-players
#13
Fraser Carson, Remco C J Polman
BACKGROUND: The aim of the present study was to explore the views of professional rugby union players during the early rehabilitation, late rehabilitation and return to play stages, following anterior cruciate ligament (ACL) injury. METHODS: A qualitative dominant, mixed methodological approach was utilized with five players who had suffered an ACL injury requiring reconstructive surgery. A longitudinal approach, concurrent with each player's rehabilitation, consisting of twice monthly interviews, a self-report diary and three established questionnaires (MOS-Social Support Survey, Sherbourne & Stewart, 1991; Sport Climate Questionnaire, Deci & Ryan, n...
2017: BMC Sports Science, Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28114932/alternative-financing-mechanisms-for-art-programs-in-health-facilities-in-uganda-a-mixed-methods-approach
#14
Henry Zakumumpa, Sara Bennett, Freddie Ssengooba
BACKGROUND: Sub-Saharan Africa is heavily dependent on global health initiatives (GHIs) for funding antiretroviral therapy (ART) scale-up. There are indications that global investments for ART scale-up are flattening. It is unclear what new funding channels can bridge the funding gap for ART service delivery. Many previous studies have focused on domestic government spending and international funding especially from GHIs. The objective of this study was to identify the funding strategies adopted by health facilities in Uganda to sustain ART programs between 2004 and 2014 and to explore variations in financing mechanisms by ownership of health facility...
January 23, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28097223/abca7-loss-of-function-variants-expression-and-neurologic-disease-risk
#15
Mariet Allen, Sarah J Lincoln, Morgane Corda, Jens O Watzlawik, Minerva M Carrasquillo, Joseph S Reddy, Jeremy D Burgess, Thuy Nguyen, Kimberly Malphrus, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Nilüfer Ertekin-Taner
OBJECTIVE: To investigate and characterize putative "loss-of-function" (LOF) adenosine triphosphate-binding cassette, subfamily A member 7 (ABCA7) mutations reported to associate with Alzheimer disease (AD) risk. METHODS: We genotyped 6 previously reported ABCA7 putative LOF variants in 1,465 participants with AD, 381 participants with other neuropathologies (non-AD), and 1,043 controls and assessed the overall mutational burden for association with different diagnosis groups...
February 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28088185/igc-an-integrated-analysis-package-of-gene-expression-and-copy-number-alteration
#16
Yi-Pin Lai, Liang-Bo Wang, Wei-An Wang, Liang-Chuan Lai, Mong-Hsun Tsai, Tzu-Pin Lu, Eric Y Chuang
BACKGROUND: With the advancement in high-throughput technologies, researchers can simultaneously investigate gene expression and copy number alteration (CNA) data from individual patients at a lower cost. Traditional analysis methods analyze each type of data individually and integrate their results using Venn diagrams. Challenges arise, however, when the results are irreproducible and inconsistent across multiple platforms. To address these issues, one possible approach is to concurrently analyze both gene expression profiling and CNAs in the same individual...
January 14, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28077705/processing-of-intraoral-olfactory-and-gustatory-signals-in-the-gustatory-cortex-of-awake-rats
#17
Chad L Samuelsen, Alfredo Fontanini
: The integration of gustatory and olfactory information is essential to the perception of flavor. Human neuroimaging experiments have pointed to the gustatory cortex (GC) as one of the areas involved in mediating flavor perception. Although GC's involvement in encoding the chemical identity and hedonic value of taste stimuli is well studied, it is unknown how single GC neurons process olfactory stimuli emanating from the mouth. In this study, we relied on multielectrode recordings to investigate how single GC neurons respond to intraorally delivered tastants and tasteless odorants dissolved in water and whether/how these two modalities converge in the same neurons...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28067777/a-fuzzy-based-approach-for-sensing-coding-and-transmission-configuration-of-visual-sensors-in-smart-city-applications
#18
Daniel G Costa, Mario Collotta, Giovanni Pau, Cristian Duran-Faundez
The advance of technologies in several areas has allowed the development of smart city applications, which can improve the way of life in modern cities. When employing visual sensors in that scenario, still images and video streams may be retrieved from monitored areas, potentially providing valuable data for many applications. Actually, visual sensor networks may need to be highly dynamic, reflecting the changing of parameters in smart cities. In this context, characteristics of visual sensors and conditions of the monitored environment, as well as the status of other concurrent monitoring systems, may affect how visual sensors collect, encode and transmit information...
January 5, 2017: Sensors
https://www.readbyqxmd.com/read/28066963/phenotiki-an-open-software-and-hardware-platform-for-affordable-and-easy-image-based-phenotyping-of-rosette-shaped-plants
#19
Massimo Minervini, Mario Valerio Giuffrida, Pierdomenico Perata, Sotirios A Tsaftaris
Phenotyping is important to understand plant biology but current solutions are either costly, not versatile or difficult to deploy. To solve this problem, we present Phenotiki, an affordable system for plant phenotyping which, relying on off-the-shelf parts, provides an easy to install and maintain platform, offering an out-of-box experience for a well established phenotyping need: imaging rosette-shaped plants. The accompanying software (with available source code) processes data originating from our device seamlessly and automatically...
January 9, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28062180/determination-of-cryothermal-injury-thresholds-in-tissues-impacted-by-cardiac-cryoablation
#20
Ryan P Goff, Stephen G Quallich, Robert A Buechler, John C Bischof, Paul A Iaizzo
Despite widespread clinical use of cryoablation, there remain questions regarding dosing and treatment times which may affect efficacy and collateral injury. Dosing and treatment times are directly related to the degree of cooling necessary for effective lesion formation. Human and swine atrial, ventricular, and lung tissues were ablated using two cryoablation systems with concurrent infrared thermography. Post freeze-thaw samples were cultured and stained to differentiate viable and non-viable tissue. Matlab code correlated viability staining to applied freeze-thaw thermal cycles, to determine injury thresholds...
January 3, 2017: Cryobiology
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