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https://www.readbyqxmd.com/read/27904775/disease-evolution-and-heterogeneity-in-bilateral-breast-cancer
#1
Elena Fountzilas, Vassiliki Kotoula, Flora Zagouri, Eleni Giannoulatou, George Kouvatseas, George Pentheroudakis, Triantafyllia Koletsa, Mattheos Bobos, Kyriaki Papadopoulou, Epaminontas Samantas, Efterpi Demiri, Spyros Miliaras, Christos Christodoulou, Sofia Chrisafi, Evangelia Razis, Florentia Fostira, Dimitrios Pectasides, George Zografos, George Fountzilas
Bilateral breast cancers (BBC) are currently treated as independent tumors arising in the same patient. Herein, we investigated whether BBC indeed evolve independently at the genomic level. We examined paired targeted next generation sequencing genotypes from 155 paraffin tumors corresponding to 76 BBC patients (75 women and one man; 52 concurrent and 24 metachronous), for coding mutations (amino acid changing, minor allele frequency <0.1%) and single nucleotide polymorphism (SNP) zygosity. Germline genotypes were available for 29 patients...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27893618/early-resuscitation-with-lyophilized-plasma-provides-equal-neuroprotection-compared-with-fresh-frozen-plasma-in-a-large-animal-survival-model-of-traumatic-brain-injury-and-hemorrhagic-shock
#2
Ihab Halaweish, Ted Bambakidis, Vahagn C Nikolian, Patrick Georgoff, Peter Bruhn, Patryk Piascik, Lisa Buckley, Ashok Srinivasan, Baoling Liu, Yongqing Li, Hasan B Alam
BACKGROUND: Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) is highly lethal. In previous models of combined TBI + HS, we showed that early resuscitation with fresh frozen plasma (FFP) improves neurologic outcomes. Delivering FFP, however, in austere environments is difficult. Lyophilized plasma (LP) is a logistically superior alternative to FFP, but data are limited regarding its efficacy for treatment of TBI. We conducted this study to determine the safety and long-term outcomes of early treatment with LP in a large animal model of TBI + HS...
December 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27889470/delayed-administration-of-dopaminergic-drugs-is-not-associated-with-prolonged-length-of-stay-of-hospitalized-patients-with-parkinson-s-disease
#3
Rob Skelly, Lisa Brown, Andrew Fogarty
BACKGROUND: Punctual delivery of dopaminergic medication to Parkinson's disease (PD) patients may be important in optimizing disease control. We tested the hypothesis that prompt delivery of l-dopa medications to emergency hospital inpatients was associated with a decreased length of stay in hospital. METHODS: The study population consisted of all urgent hospitalizations for patients with a diagnosis of PD to the Royal Derby Hospital over a two-year period. Data were extracted on timing of delivery of drugs, number of co-morbidities and length of stay...
November 14, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27869105/an-open-access-database-for-the-evaluation-of-heart-sound-algorithms
#4
Chengyu Liu, David Springer, Qiao Li, Benjamin Moody, Ricardo Abad Juan, Francisco J Chorro, Francisco Castells, José Millet Roig, Ikaro Silva, Alistair E W Johnson, Zeeshan Syed, Samuel E Schmidt, Chrysa D Papadaniil, Leontios Hadjileontiadis, Hosein Naseri, Ali Moukadem, Alain Dieterlen, Christian Brandt, Hong Tang, Maryam Samieinasab, Mohammad Reza Samieinasab, Reza Sameni, Roger G Mark, Gari D Clifford
In the past few decades, analysis of heart sound signals (i.e. the phonocardiogram or PCG), especially for automated heart sound segmentation and classification, has been widely studied and has been reported to have the potential value to detect pathology accurately in clinical applications. However, comparative analyses of algorithms in the literature have been hindered by the lack of high-quality, rigorously validated, and standardized open databases of heart sound recordings. This paper describes a public heart sound database, assembled for an international competition, the PhysioNet/Computing in Cardiology (CinC) Challenge 2016...
November 21, 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27865922/low-frequency-cortical-oscillations-are-modulated-by-temporal-prediction-and-temporal-error-coding
#5
Louise Catheryne Barne, Peter Maurice Erna Claessens, Marcelo Bussotti Reyes, Marcelo Salvador Caetano, André Mascioli Cravo
Monitoring and updating temporal predictions are critical abilities for adaptive behavior. Here, we investigated whether neural oscillations are related to violation and updating of temporal predictions. Human participants performed an experiment in which they had to generate a target at an expected time point, by pressing a button while taking into account a variable delay between the act and the stimulus occurrence. Our behavioral results showed that participants quickly adapted their temporal predictions in face of an error...
November 16, 2016: NeuroImage
https://www.readbyqxmd.com/read/27862571/avoidant-conversations-about-death-by-clinicians-causes-delays-in-reporting-of-neutropenic-sepsis-grounded-theory-study
#6
Catherine Oakley, Cath Taylor, Emma Ream, Alison Metcalfe
BACKGROUND: Evidence suggests patients delay reporting symptoms of neutropenic sepsis (NS) despite the risk to their life. This study aimed to elicit factors that contribute to delayed patient reporting of NS symptoms. METHODS: A constructivist grounded theory study used observations of chemotherapy consultations (13 hours) and 31 in-depth interviews to explore beliefs, experiences and behaviors related to NS. Participants included women with breast cancer, their carers (partners, family or friends) and clinicians...
November 18, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27852677/processing-of-intraoral-olfactory-and-gustatory-signals-in-the-gustatory-cortex-of-awake-rats
#7
Chad L Samuelsen, Alfredo Fontanini
: The integration of gustatory and olfactory information is essential to the perception of flavor. Human neuroimaging experiments have pointed to the gustatory cortex (GC) as one of the areas involved in mediating flavor perception. While GC's involvement in encoding the chemical identity and hedonic value of taste stimuli is well studied, it is unknown how single GC neurons process olfactory stimuli emanating from the mouth. In this study, we relied on multi-electrode recordings to investigate how single GC neurons respond to intraorally delivered tastants and tasteless odorants dissolved in water and whether/how these two modalities converge in the same neurons...
November 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27852333/emergency-department-visits-for-attempted-suicide-and-self-harm-in-the-usa-2006-2013
#8
J K Canner, K Giuliano, S Selvarajah, E R Hammond, E B Schneider
AIMS: To characterise and identify nationwide trends in suicide-related emergency department (ED) visits in the USA from 2006 to 2013. METHODS: We used data from the Nationwide Emergency Department Sample (NEDS) from 2006 to 2013. E-codes were used to identify ED visits related to suicide attempts and self-inflicted injury. Visits were characterised by factors such as age, sex, US census region, calendar month, as well as injury severity and mechanism. Injury severity and mechanism were compared between age groups and sex by chi-square tests and Wilcoxon rank-sum tests...
November 17, 2016: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/27829303/psychometric-validation-of-the-electronic-chronic-pain-questions-ecpq-in-a-primary-care-setting
#9
Karin S Coyne, Brooke M Currie, Sean Donevan, Marina Brodsky, Michael J Asmus, Daniel W Krichbaum, Joseph C Cappelleri, Rozelle Hegeman-Dingle, Alesia Sadosky, Samuel Z Whipple, Claire Burbridge, Elie Mulhem, J Bruce Hillenberg
OBJECTIVE: Collecting data that helps evaluate different types of pain may improve physicians' decision-making with regard to treatment selection and on-going monitoring of patients. To date, no chronic pain assessments have been widely implemented in primary care. The aim of this study was to psychometrically validate the electronic Chronic Pain Questions (eCPQ) in a primary care setting. RESEARCH DESIGN AND METHODS: All men and women ≥18 years arriving at two similar primary care clinics in southeastern Michigan were invited to participate...
November 10, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27823757/how-does-a-concurrent-diagnosis-of-cancer-influence-outcomes-in-emergency-general-surgery-patients
#10
Adil A Shah, Syed Nabeel Zafar, Awais Ashfaq, Alyssa B Chapital, Daniel J Johnson, Chee-Chee Stucky, Barbara Pockaj, Richard J Gray, Mallory Williams, Edward E Cornwell, Lori L Wilson, Nabil Wasif
BACKGROUND: A significant proportion of hospital admissions in the US are secondary to emergency general surgery (EGS). The aim of this study is to quantify outcomes for EGS patients with cancer. METHODS: The Nationwide Inpatient Sample (2007 to 2011) was queried for patients with a diagnosis of an EGS condition as determined by the American Association for the Surgery of Trauma. Of these, patients with a diagnosis of malignant cancers (ICD-9-CM diagnosis codes; 140-208...
September 30, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27815131/sensory-coding-and-cognitive-processing-of-sound-in-veterans-with-blast-exposure
#11
Scott Bressler, Hannah Goldberg, Barbara Shinn-Cunningham
Recent anecdotal reports from VA audiology clinics as well as a few published studies have identified a sub-population of Service Members seeking treatment for problems communicating in everyday, noisy listening environments despite having normal to near-normal hearing thresholds. Because of their increased risk of exposure to dangerous levels of prolonged noise and transient explosive blast events, communication problems in these soldiers could be due to either hearing loss (traditional or "hidden") in the auditory sensory periphery or from blast-induced injury to cortical networks associated with attention...
November 2, 2016: Hearing Research
https://www.readbyqxmd.com/read/27809374/the-process-of-patient-enablement-in-general-practice-nurse-consultations-a-grounded-theory-study
#12
Jane Desborough, Michelle Banfield, Christine Phillips, Jane Mills
AIM: The aim of this study was to gain insight into the process of patient enablement in general practice nursing consultations. BACKGROUND: Enhanced roles for general practice nurses may benefit patients through a range of mechanisms, one of which may be increasing patient enablement. In studies with general practitioners enhanced patient enablement has been associated with increases in self-efficacy and skill development. DESIGN: This study used a constructivist grounded theory design...
November 3, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27795739/the-open-spectral-database-an-open-platform-for-sharing-and-searching-spectral-data
#13
Stuart J Chalk
BACKGROUND: A number of websites make available spectral data for download (typically as JCAMP-DX text files) and one (ChemSpider) that also allows users to contribute spectral files. As a result, searching and retrieving such spectral data can be time consuming, and difficult to reuse if the data is compressed in the JCAMP-DX file. What is needed is a single resource that allows submission of JCAMP-DX files, export of the raw data in multiple formats, searching based on multiple chemical identifiers, and is open in terms of license and access...
2016: Journal of Cheminformatics
https://www.readbyqxmd.com/read/27764589/a-combinatorial-model-for-dentate-gyrus-sparse-coding
#14
William Severa, Ojas Parekh, Conrad D James, James B Aimone
The dentate gyrus forms a critical link between the entorhinal cortex and CA3 by providing a sparse version of the signal. Concurrent with this increase in sparsity, a widely accepted theory suggests the dentate gyrus performs pattern separation-similar inputs yield decorrelated outputs. Although an active region of study and theory, few logically rigorous arguments detail the dentate gyrus's (DG) coding. We suggest a theoretically tractable, combinatorial model for this action. The model provides formal methods for a highly redundant, arbitrarily sparse, and decorrelated output signal...
October 20, 2016: Neural Computation
https://www.readbyqxmd.com/read/27757055/reliability-and-validity-of-the-italian-version-of-the-14-item-resilience-scale
#15
Camilla Callegari, Lorenza Bertù, Melissa Lucano, Marta Ielmini, Elena Braggio, Simone Vender
BACKGROUND: In recent years resilience has gained clinical relevance in sociological, psychological, and medical disciplines, and a lot of scales measuring resilience have been developed and have been utilized in the western countries. The aim of the study was to assess the psychometric properties of the Italian version of the 14-item Resilience Scale (RS-14), by describing its validity and reliability. As agreed with the authors of the original English version of the RS-14, it was translated into Italian...
2016: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/27749468/chronic-pain-patients-perceptions-of-their-future-a-verbal-fluency-task
#16
Adina C Rusu, Tamar Pincus
Depression is a common feature of chronic pain, but the content of depressed cognitions in groups with chronic pain may be qualitatively different from other depressed groups. Future thinking has been extensively studied in depressed population, however, to our knowledge this is the first study to investigate future thinking, using a verbal fluency task, in chronic pain. This study investigated the content of cognitions about the future, which are postulated to be a key mechanism in the development of clinical depression, but have not been studies in groups with chronic pain...
October 1, 2016: Pain
https://www.readbyqxmd.com/read/27743423/the-patient-care-paradox-an-interprofessional-qualitative-study-of-agitated-patient-care-in-the-emergency-department
#17
Ambrose Hon-Wai Wong, Joan Combellick, Beth Ann Wispelwey, Allison Squires, Maureen Gang
OBJECTIVES: The emergency department (ED) has been recognized as a high-risk environment for workplace violence. Acutely agitated patients who perpetrate violence against healthcare workers represent a complex care challenge in the ED. Recommendations to improve safety are often based on expert opinion rather than empirical data. In this study we aim to describe the lived experience of staff members caring for this population in order to provide a broad perspective of ED patient violence...
October 15, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27741229/theta-gamma-coding-meets-communication-through-coherence-neuronal-oscillatory-multiplexing-theories-reconciled
#18
Douglas McLelland, Rufin VanRullen
Several theories have been advanced to explain how cross-frequency coupling, the interaction of neuronal oscillations at different frequencies, could enable item multiplexing in neural systems. The communication-through-coherence theory proposes that phase-matching of gamma oscillations between areas enables selective processing of a single item at a time, and a later refinement of the theory includes a theta-frequency oscillation that provides a periodic reset of the system. Alternatively, the theta-gamma neural code theory proposes that a sequence of items is processed, one per gamma cycle, and that this sequence is repeated or updated across theta cycles...
October 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27739524/characterization-of-factors-underlying-the-metabolic-shifts-in-developing-kernels-of-colored-maize
#19
Chaoyang Hu, Quanlin Li, Xuefang Shen, Sheng Quan, Hong Lin, Lei Duan, Yifa Wang, Qian Luo, Guorun Qu, Qing Han, Yuan Lu, Dabing Zhang, Zheng Yuan, Jianxin Shi
Elucidation of the metabolic pathways determining pigmentation and their underlying regulatory mechanisms in maize kernels is of high importance in attempts to improve the nutritional composition of our food. In this study, we compared dynamics in the transcriptome and metabolome between colored SW93 and white SW48 by integrating RNA-Seq and non-targeted metabolomics. Our data revealed that expression of enzyme coding genes and levels of primary metabolites decreased gradually from 11 to 21 DAP, corresponding well with the physiological change of developing maize kernels from differentiation through reserve accumulation to maturation, which was cultivar independent...
October 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27725219/hidden-morbidity-of-ventral-hernia-repair-with-mesh-as-concerning-as-common-bile-duct-injury
#20
Kristy Kummerow Broman, Li-Ching Huang, Adil Faqih, Sharon E Phillips, Rebeccah B Baucom, Richard A Pierce, Michael D Holzman, Kenneth W Sharp, Benjamin K Poulose
BACKGROUND: Ventral hernia repair with mesh is increasingly common, but the incidence of long term complications that necessitate mesh explantation is unknown. We aimed to determine the epidemiology of mesh explantation after ventral hernia repair and to compare this with common bile duct injury, a dreaded complication of laparoscopic cholecystectomy. STUDY DESIGN: We evaluated a retrospective cohort of patients undergoing ventral hernia repair by linking the all-payers State Inpatient Databases and State Ambulatory Surgery Databases for NY, CA, and FL...
October 7, 2016: Journal of the American College of Surgeons
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