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Acellular dermal matrix

Andrea Barnow, Todd Canfield, Ray Liao, Sashi Yadalam, Iftekhar Kalsekar, Rahul Khanna
INTRODUCTION: This study evaluated trends related to breast reconstruction and the factors associated with reconstruction. METHODS: Women with breast cancer aged 19 to 64 years who underwent a mastectomy procedure between July 1, 2011, and September 30, 2014, were identified from the MarketScan Commercial Claims and Encounters Database. The first date of surgical procedure during this period was defined as the index date. Continuous enrollment during the 12-month preindex and postindex period was required, and the patient sample was followed for 12 months postindex...
May 17, 2018: Annals of Plastic Surgery
Windy Cole, Brian Samsell, Mark A Moore
Achilles tendon ruptures are common in the general population, especially among members of the older demographic occasionally active in sports. Operative treatments provide a lower incidence of rerupture than do nonoperative treatments, although surgical complications remain a concern. The use of a human acellular dermal matrix to augment Achilles tendon repair might reduce the incidence of complications. In the present case series, we describe the outcomes of 9 patients who underwent Achilles tendon repair with acellular dermal matrix augmentation...
May 17, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Er-Jia Mao
The main purposes of periodontal graft surgery include achieving root coverage, improving the clinical attachment level and keratinized tissue, and advancing the procedure of periodontal plastic surgery. Autogenous graft, such as subepithelial connective tissue graft-based procedure, provide the best outcomes for mean and complete root coverage, as well as increase in keratinized tissue. However, a disadvantage of the procedure is in the location of the operation itself: the additional surgical site (palate)...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
Lorenzo Tavelli, Shayan Barootchi, Trang V N Nguyen, Mustafa Tattan, Andrea Ravidà, Hom-Lay Wang
BACKGROUND: Tunnel technique (TUN) has recently gained popularity among clinicians for its promising clinical and esthetic results when treating gingival recessions (GRs) defects. However, the evidence of the efficacy of TUN in the literature is still to be determined. Therefore, the aim of the present systematic review and meta-analysis was to investigate the predictability of TUN and its comparison to coronally advanced flap (CAF) procedure. MATERIAL AND METHODS: A literature search on PubMed, Cochrane libraries, EMBASE, and hand-searched journals until November 2017 was conducted to identify clinical studies investigating TUN for root coverage procedures...
May 14, 2018: Journal of Periodontology
Navid Pourtaheri, Derek Wang, Daniel Calva, Karan Chopra, Anand R Kumar
BACKGROUND: Adipofascial flaps (AFF) with acellular dermal matrix (ADM) have the potential to reconstruct neural tube defects without sacrificing muscle that may be critical for long-term function. Comparative studies between myocutaneous flap (MF) reconstruction, the accepted standard reconstructive technique, and AFF/ADM remain under-reported. The aim of this study was to evaluate the safety and efficacy of myelomeningocele reconstruction using muscle sparing AFF/ADM versus MF. METHODS: A retrospective comparison was conducted on consecutive myelomeningocele patients reconstructed with MF or AFF/ADM over an 84-month period...
May 10, 2018: Journal of Craniofacial Surgery
Jing Chu, Panpan Shi, Wenxia Yan, Jinping Fu, Zhi Yang, Chengmin He, Xiaoyuan Deng, Hanping Liu
Nanoscale delivery based on polyethylene glycol (PEG)ylated graphene oxide (GO-PEG) merits attention for biomedical applications owing to its functional surface modification, superior solubility/biocompatibility and controllable drug release capability. However, impaired skin regeneration in applications of these fascinating nanomaterials in diabetes is still limited, and critical issues need to be addressed regarding insufficient collagen hyperplasia and inadequate blood supply. Therefore, a high-performance tissue engineering scaffold with biocompatible and biodegradable properties is essential for diabetic wound healing...
May 10, 2018: Nanoscale
Andrew Simpson, Osama A Samargandi, Alison Wong, M Elise Graham, Michael Bezuhly
OBJECTIVE: The current review and survey aim to assess the effectiveness of acellular dermal matrix (ADM) in the repair of cleft palate and oronasal fistula and to evaluate the current trends of ADM use in palate surgery. DESIGN: A systematic review of English articles was conducted using MEDLINE (1960 to July 1, 2016), the Cochrane Controlled Trials Register (1960 to July 1, 2016), and EMBASE (1991 to July 1, 2016). Additional studies were identified through a review of references cited in initially identified articles...
January 1, 2018: Cleft Palate-craniofacial Journal
Cavid Ahmedbeyli, Sebnem Dirikan Ipci, Gokser Cakar, Selcuk Yilmaz
OBJECTIVES: The aim of this study was to evaluate acellular dermal matrix graft (ADM) combination with laterally positioned flap (LPF) and to compare the results with LPF alone in terms of root coverage, esthetics, and patient perspectives in gingival recessions. MATERIALS AND METHODS: Twenty-two patients with localized Miller Class I/II recessions ≥ 3 mm with gingival thickness (GT) < 0.8 mm were included. Outcome parameters such as recession height and width, keratinized tissue (KT) height, GT, mean and complete defect coverage, patient satisfaction, and root coverage esthetic score (RES) were re-evaluated at 12 months postoperatively...
May 3, 2018: Clinical Oral Investigations
Fernanda G Basso, Taisa N Pansani, Cyntia L Marcelo, Carlos Alberto de Souza Costa, Josimeri Hebling, Stephen E Feinberg
This study validates the use of a full-thickness oral mucosa model for in vitro studies with a collagen type I matrix, by comparison of this model with two other 3D oral mucosa models: human-sourced and porcine acellular dermal matrices (AlloDerm®/Strattice®, respectively). For the collagen matrix model, gingival fibroblasts were seeded either onto the dermal side of the AlloDerm® and Strattice® matrices or within the collagen matrices in complete culture medium (DMEM). For all scaffolds, DMEM was replaced every 24 h up to 72 h...
April 30, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Luo Huang, Rui Zou, Jinquan He, Kexiong Ouyang, Zhengguo Piao
Concentrated growth factor (CGF) is an autogenuous product that contains highly concentrated number of platelets and can be derived from venous blood by selective centrifugation. It has been speculated that local growth factors in human platelets (insulinlike growth factor, IGF; transforming growth factor, TGF-b; platelet derived growth factor, PDGF) would enhance healing of grafts and also counteract resorption. The osteogensis effect of CGF and acellular dermal matrix (ADM) for alveolar cleft defects was evaluated in this study...
2018: Brazilian Oral Research
Jing Sun, Xingtong Liu, Yidan Zhang, Yazhuo Huang, Sisi Zhong, Sijie Fang, Ai Zhuang, Yinwei Li, Huifang Zhou, Xianqun Fan
BACKGROUND Eyelid retraction is the most common and often the first sign of thyroid eye disease (TED). Upper-eyelid retraction causes both functional and cosmetic problems. In order to correct the position of the upper eyelid, surgery is required. Many procedures have demonstrated good outcomes in mild and moderate cases; however, unpredictable results have been obtained in severe cases. Dryden introduced an upper-eyelid-lengthening procedure, which used scleral grafts, but outcomes were unsatisfactory. A new technique is introduced in this study as a reasonable alternative for TED-related severe upper-eyelid retraction correction...
May 2, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Daniel Romeu Benchimol de Resende, Sebastião Luiz Aguiar Greghi, Aline Franco Siqueira, César Augusto Magalhães Benfatti, Carla Andreotti Damante, Mariana Schutzer Ragghianti Zangrando
OBJECTIVES: This split-mouth controlled randomized clinical trial evaluated clinical and histological results of acellular dermal matrix allograft (ADM) compared to autogenous free gingival graft (FGG) for keratinized tissue augmentation. MATERIAL AND METHODS: Twenty-five patients with the absence or deficiency of keratinized tissue (50 sites) were treated with FGG (control group) and ADM (test group). Clinical parameters included keratinized tissue width (KTW) (primary outcome), soft tissue thickness (TT), recession depth (RD), probing depth (PD), and clinical attachment level (CAL)...
April 30, 2018: Clinical Oral Investigations
Jens Holm, Lars B Stolle
Acellular Dermal Matrices have become increasing popular in breast reconstruction especially in the last decade. There is a debate on whether Acellular Dermal Matrices increase the risk of complications or not. Common complications include infection, wound dehiscence, necrosis, seroma, haematoma, capsular contracture, extrusion, loss of implant and reconstruction failure. Non-integration is not listed as a typical complication to the use of Acellular Dermal Matrices. We report a case of a completely non-integrated Acellular Dermal Matrix following breast reconstruction in a patient without significant risk factors...
2018: Case Reports in Plastic Surgery & Hand Surgery
Brooks Udelsman, Douglas J Mathisen, Harald C Ott
Aerodigestive defects involving the trachea, bronchi and esophagus are a result of prolonged intubation, operative complications, congenital defects, trauma, radiation and neoplastic disease. The vast majority of these defects may be repaired primarily. Rarely, due the size of the defect, underlying complexity, or unfavorable patient characteristics, primary repair is not possible. One alternative to primary repair is bioprosthetic repair. Materials such as acellular dermal matrix and aortic homograft have been used in a variety of applications, including closure of tracheal, bronchial and esophageal defects...
March 2018: Annals of Cardiothoracic Surgery
Craig A Blum, Frank J DellaCroce, Scott K Sullivan, Chris Trahan, M Whitten Wise
Background: When a single perforator flap does not provide adequate volume or projection for satisfactory breast reconstruction, the addition of an implant may be considered at the time of second-stage revisions. Dissection of an implant pocket beneath the flap may lead to the inadvertent injury of the flap pedicle as the tissue planes have been obscured by tissue ingrowth. The authors present a technique in which the boundaries of the implant pocket are predetermined at the time of flap reconstruction allowing an implant to be inserted at the second stage in ideal position with greater ease of dissection and minimal risk to the flap pedicle...
March 2018: Plastic and Reconstructive Surgery. Global Open
Omri Emodi, Jiriys George Ginini, John A van Aalst, Dekel Shilo, Raja Naddaf, Dror Aizenbud, Adi Rachmiel
Fistulas represent failure of cleft palate repair. Secondary and tertiary fistula repair is challenging, with high recurrence rates. In the present retrospective study, we review the efficacy of using acellular dermal matrix as an interposition layer for cleft palate fistula closure in 20 consecutive patients between 2013 and 2016. Complete fistula closure was obtained in 16 patients; 1 patient had asymptomatic recurrent fistula; 2 patients had partial closure with reduction of fistula size and minimal nasal regurgitation; 1 patient developed a recurrent fistula without changes in symptoms (success rate of 85%)...
March 2018: Plastic and Reconstructive Surgery. Global Open
Benjamin G Baker, Renu Irri, Vivienne MacCallum, Rahul Chattopadhyay, John Murphy, James R Harvey
BACKGROUND: Prepectoral acellular dermal matrix-assisted immediate implant-based breast reconstruction is gaining popularity, involving complete implant coverage with acellular dermal matrix. The authors aimed to compare pain, patient-reported outcome measures (including implant rippling), and safety of prepectoral and subpectoral Strattice-assisted implant-based breast reconstruction. METHODS: Consecutive patients were recruited prospectively, having either therapeutic or risk-reducing mastectomy...
May 2018: Plastic and Reconstructive Surgery
Charles M Zelen, Dennis P Orgill, Thomas E Serena, Robert E Galiano, Marissa J Carter, Lawrence A DiDomenico, Jennifer Keller, Jarrod P Kaufman, William W Li
Aseptically processed human reticular acellular dermal matrix (HR-ADM) has been previously shown to improve wound closure in 40 diabetic patients with non-healing foot ulcers. The study was extended to 40 additional patients (80 in total) to validate and extend the original findings. The entire cohort of 80 patients underwent appropriate offloading and standard of care (SOC) during a 2-week screening period and, after meeting eligibility criteria, were randomised to receive weekly applications of HR-ADM plus SOC or SOC alone for up to 12 weeks...
April 22, 2018: International Wound Journal
Giorgio Lisi, M Campanelli, S Grande, M Grande, D Mascagni, G Milito
PURPOSE: Symptomatic rectocele results in obstructed defecation and constipation. Surgical repair may provide symptomatic relief. A variety of surgical procedures have been used in the rectocele repair to enhance anatomical and functional results and to improve long-term outcomes. METHODS: In this prospective study, we treated 25 selected women suffering from simple symptomatic rectocele with transperineal repair using porcine dermal acellular collagen matrix Biomesh (Permacol®)...
April 19, 2018: International Journal of Colorectal Disease
Seo H Lee, Yong S Chun, Heung K Park, Yang W Kim, Young W Cheon
BACKGROUND: Elevation of a conjoined fascial flap composed of the pectoralis major, serratus anterior, and external oblique fascia is a type of surgical technique using autologous tissue to cover the lower pole after immediate one-stage direct-to-implant (DTI) breast reconstruction. However, volumetric breast implants hinder use of this technique alone. For better structural stability and more aesthetically favorable breast contour in large breasts, we have devised a technique involving dual coverage of the lower pole by a conjoined fascial flap and acellular dermal matrix (ADM)...
April 17, 2018: Aesthetic Plastic Surgery
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