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Acellular dermal matrix

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https://www.readbyqxmd.com/read/28444764/prospective-unbiased-experience-with-three-acellular-dermal-matrices-in-breast-reconstruction
#1
Edward I Chang, Jun Liu
BACKGROUND: The use of acellular dermal matrix (ADM) has become the standard of care in breast reconstruction. However, the majority of current studies are biased or combine large databases introducing inherent flaws. Here, we present a prospective single surgeon experience comparing three ADM. METHODS: All expander based breast reconstructions between 2014 and 2015 using ADM were included. RESULTS: Eighteen patients (32 breasts) underwent reconstruction using Flex Pliable, 15 patients (22 breasts) used Alloderm, and 14 patients (20 breasts) had Dermacell...
April 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28423561/dermis-acellular-dermal-matrix-and-fibroblasts-from-different-layers-of-pig-skin-exhibit-different-profibrotic-characteristics-evidence-from-in-vivo-study
#2
Yanhai Zuo, Shuliang Lu
To explore the profibrotic characteristics of the autografted dermis, acellular dermal matrix, and dermal fibroblasts from superficial/deep layers of pig skin, 93 wounds were established on the dorsa of 7 pigs. 72 wounds autografted with the superficial/deep dermis and acellular dermal matrix served as the superficial/deep dermis and acellular dermal matrix group, respectively, and were sampled at 2, 4, and 8 weeks post-wounding. 21 wounds autografted with/without superficial/deep dermal fibroblasts served as the superficial/deep dermal fibroblast group and the control group, respectively, and were sampled at 2 weeks post-wounding...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412332/congenital-aphallia-novel-use-of-acellular-dermal-matrix-during-scrotal-flap-phalloplasty
#3
Rajeev Chaudhry, Katherine M Theisen, Pankaj P Dangle, Francis Schneck
Phallic reconstruction is an important part of management for congenital aphallia. Scrotal flap phalloplasty has been described in pediatric patients to create the appearance of a non-functioning phallus. We describe a modified scrotal flap technique with the addition of an acellular dermal matrix patch (AlloDerm®) to provide additional girth and support to the phallus. The post-operative cosmetic outcome has been satisfactory and there is no documented complication over a 12 month follow-up. Alloderm® dermal matrix can be a safe addition to phallic reconstruction and its overall application needs to be further studied...
April 12, 2017: Urology
https://www.readbyqxmd.com/read/28396274/acellular-dermal-matrix-for-esophageal-stricture-prevention-after-endoscopic-submucosal-dissection-in-a-porcine-model
#4
Ye Han, Jintao Guo, Siyu Sun, Weichao Wu, Sheng Wang, Nan Ge, Xiang Liu, Guoxin Wang, Shupeng Wang
BACKGROUND AND AIMS: Endoscopic submucosal dissection (ESD) is considered an effective treatment for early esophageal cancer and precancerous lesions. Esophageal stenosis is closely associated with quasi-circumferential ESD. We examined whether post-ESD esophageal stricture can be prevented by grafting an acellular dermal matrix (ADM) membrane. METHODS: Fourteen Bama miniature pigs were randomly divided into an ADM group (n=7) and a control group (n=7). Semi-circumferential ESD was performed at the distal esophagus in all animals, and in the ADM group, an ADM patch graft was placed at the resection site and secured innovatively with metal clips...
April 7, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28366460/polytetrafluoroethylene-or-acellular-dermal-matrix-for-diaphragmatic-reconstruction
#5
Juri K Bassuner, David C Rice, Mara B Antonoff, Arlene M Correa, Garrett L Walsh, Ara A Vaporciyan, Naveen Garg, Boris Sepesi, Stephen G Swisher, Wayne L Hofstetter, Jack A Roth, Reza J Mehran
BACKGROUND: We aimed to evaluate the impact of collagen matrix in the reconstruction of the diaphragm. METHODS: We queried the electronic medical record for patients who had resection of the diaphragm and simultaneous pulmonary resection between 1999 and 2016. All reconstructions were performed with either polytetrafluoroethylene or acellular dermal matrix. We evaluated the rate of empyema and herniation in each group. RESULTS: A total of 208 patients met inclusion criteria...
March 30, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28364524/extended-submuscular-implant-based-breast-reconstruction-with-pectoralis-serratus-sling-and-acellular-dermal-matrix
#6
Adam R Kolker, Paulo P Piccolo
No abstract text is available yet for this article.
April 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28350687/reply-acellular-dermal-matrix-assisted-direct-to-implant-breast-reconstruction-and-capsular-contracture-a-13-year-experience
#7
C Andrew Salzberg
No abstract text is available yet for this article.
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28350650/direct-to-implant-breast-reconstruction-without-the-use-of-an-acellular-dermal-matrix-is-cost-effective-and-oncologically-safe
#8
L Charles J Serrurier, Sarah Rayne, Marisse Venter, Carol-Ann Benn
BACKGROUND: Direct-to-implant breast reconstruction is a predictable, reliable, and cost-effective reconstruction. Most units performing direct-to-implant reconstructions recommend the use of an acellular dermal matrix or a mesh to reinforce the lower pole of the breast reconstruction. METHODS: Two hundred seventy-two consecutive patients with 488 immediate direct-to-implant breast reconstructions performed in a 34-month period are included in this group. Mean follow-up of this group is 35 months...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28347699/effect-of-adipose-derived-stem-cells-on-acellular-dermal-matrix-engraftment-in-a-rabbit-model-of-breast-reconstruction
#9
Ung Sik Jin, Ki Yong Hong, Young-Il Hwang
Acellular dermal matrix (ADM) is frequently used in implant-based breast reconstruction. Although there are several advantages, ADM implantation also increases the risk of certain complications. Recently, ADM seeded with adipose-derived stem cells (ADSCs) were shown to induce angiogenesis and improve wound healing. This study aimed to investigate the effects of ADSCs on ADM engraftment in a rabbit model of implant-based breast reconstruction. Silicone implants were inserted to submuscular pocket of 16 female New Zealand rabbits using ADM with or without seeding of fluorescent PKH26-labelled rabbit ADSCs...
February 28, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28323545/creation-of-a-bioengineered-skin-flap-scaffold-with-a-perfusable-vascular-pedicle
#10
Bernhard J Jank, Jeremy Goverman, Jacques P Guyette, Jon M Charest, Mark A Randolph, Glenn R Gaudette, Joshua R Gershlak, Martin Purschke, Emilia Javorsky, Rosalynn M Nazarian, David A Leonard, Curtis L Cetrulo, William G Austen, Harald Christian Ott
Full thickness skin loss is a challenging problem due to limited reconstructive options, demanding 75 million surgical procedures annually in the United States. Autologous skin grafting is the gold standard treatment, but results in donor site morbidity and poor aesthetics. Numerous skin substitutes are available on the market to date, however, none truly function as full thickness skin due to their lack of a vascular network. The creation of an autologous full thickness skin analogue with a vascular pedicle would result in a paradigm shift in the management of wounds and in reconstruction of full thickness skin defects...
March 21, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28323389/atomic-force-microscopy-in-the-production-of-a-biovital-skin-graft-based-on-human-acellular-dermal-matrix-produced-in-house-and-in-vitro-cultured-human-fibroblasts
#11
Wojciech Łabuś, Justyna Glik, Agnieszka Klama-Baryła, Diana Kitala, Małgorzata Kraut, Mariusz Maj, Mariusz Nowak, Marcelina Misiuga, Andrzej Marcinkowski, Barbara Trzebicka, Ryszard Poloczek, Marek Kawecki
The most efficient method in III° burn treatment is the use of the autologous split thickness skin grafts that were donated from undamaged body area. The main limitation of this method is lack of suitable donor sites. Tissue engineering is a useful tool to solve this problem. The goal of this study was to find the most efficient way of producing biovital skin substitute based on in house produced acellular dermal matrix ADM and in vitro cultured fibroblasts. Sixty samples of sterilized human allogeneic skin (that came from 10 different donors) were used to examine the influence of decellularizing substances on extracellular matrix and clinical usefulness of the test samples of allogeneic human dermis...
March 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28321377/single-layer-repair-of-large-anterior-skull-base-defects-without-vascularized-mucosal-flap
#12
Frederick Yoo, Marilene B Wang, Marvin Bergsneider, Jeffrey D Suh
Objectives Bilateral anterior skull base (ASB) defects following endoscopic endonasal tumor resection are most commonly repaired utilizing multilayered reconstruction with a vascularized mucosal flap. Single-layer closure of large ASB defects has been described in the literature but this technique has yet to gain a widespread use. We report our experience with a series of patients who underwent reconstruction of large ASB defects using a single-layer intradural graft, without nasoseptal flaps. We also compared the use of acellular dermal matrix (AlloDerm, LifeCell, Branchburg, New Jersey, United States) or collagen matrix xenograft (Duramatrix, Stryker, Kalamazoo, Michigan, United States) as the graft biomaterial...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28301366/management-of-mastectomy-skin-necrosis-in-implant-based-breast-reconstruction
#13
Gloria R Sue, Chao Long, Gordon K Lee
BACKGROUND: Mastectomy skin necrosis is a significant problem after breast reconstruction. This complication may lead to poor wound healing and need for implant removal, which may delay subsequent oncologic treatment. We sought to characterize factors associated with mastectomy skin necrosis and propose a management algorithm. METHODS: A retrospective review was performed on consecutive patients undergoing implant-based breast reconstruction by the senior author from 2006 through 2015...
May 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28296716/dermal-autograft-using-donor-breast-as-alternative-to-acellular-dermal-matrices-in-tissue-expander-breast-reconstruction-a-comparative-review
#14
William Darden North, Christopher S Kubajak, Brad St Martin, Brian Rinker
BACKGROUND: Shifting preference for implant-based breast reconstruction has resulted in an increased use of acellular dermal matrix (ADM) in tissue-expander breast reconstruction. The benefits afforded by ADM must be weighed against a potential increased risk for postoperative complications. Dermal autograft-assisted breast reconstruction using autograft harvest from the lower abdomen has been shown to result in equivalent aesthetics and patient satisfaction compared with ADM at a lower cost, with fewer complications...
March 14, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28280894/clinical-outcomes-in-breast-reconstruction-patients-using-a-sterile-acellular-dermal-matrix-allograft
#15
Juan A Ortiz
BACKGROUND: Human acellular dermal matrices (ADMs) have enabled successful breast reconstructions while decreasing muscle donor morbidity and pain for the patient. However, some literature reports indicate an increase in complications, especially infection. The decellularization and terminal sterilization properties of DermACELL (D-ADM), a human ADM, may reduce the rate of complications in augmented breast reconstruction while still maintaining successful outcomes. In the study presented here, we evaluate the quality and safety of outcomes with the use of D-ADM during tissue expander breast reconstruction...
March 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28280672/obesity-related-risk-factors-in-implant-based-breast-reconstruction-using-alloderm
#16
James C Yuen, Cathryn A Coleman, Stephen W Erickson
With a population in which 70% of the patients were overweight or obese, we reviewed retrospectively 135 breasts of 70 consecutive patients who underwent implant-based immediate breast reconstruction using freeze-dried AlloDerm as the acellular dermal matrix. Several obesity-related parameters were evaluated to determine their possible correlation to early postoperative complications. We found that breast width and surface area of AlloDerm usage correlated with the development of infection and mastectomy skin flap necrosis...
February 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28273056/technique-to-promote-symmetry-in-2-staged-bilateral-breast-reconstruction-in-the-setting-of-unilateral-postmastectomy-radiation
#17
Daniel S Roh, Matthew D Treiser, Emily H Lafleur, Yoon S Chun
BACKGROUND: Bilateral breast reconstruction in the setting of unilateral postmastectomy radiation therapy (PMRT) remains one of the most difficult reconstructive challenges due to significant radiation-induced asymmetry from capsular contracture and superior migration of the irradiated reconstructed breast. We describe a novel and straightforward intraoperative technique for creating compensatory asymmetry to maximize postradiation symmetry in immediate bilateral tissue expander (TE) and acellular dermal matrix (ADM) reconstruction requiring unilateral PMRT...
April 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28272148/predictors-for-frey-syndrome-development-after-parotidectomy-size-does-matter
#18
Chung Ching Lee, Richie Chiu-Lung Chan, Jimmy Yu-Wai Chan
BACKGROUND: Frey syndrome is a common complication after parotidectomy. The aim of this study is to investigate potential predictors for development of Frey syndrome and explore their implications in additional prophylactic procedures. To the best of our knowledge, this is the first study to address these issues. METHODS: A computer search was performed to identify all patients who received parotidectomy from January 2009 to December 2011 in Queen Mary Hospital, Hong Kong...
March 7, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28272011/human-reticular-acellular-dermal-matrix-in-the-healing-of-chronic-diabetic-foot-ulcerations-that-failed-standard-conservative-treatment-a-retrospective-crossover-study
#19
Charles M Zelen, Dennis P Orgill, Thomas E Serena, Robert D Galiano, Marissa J Carter, Lawrence A DiDomenico, Jarrod P Kaufman, Jennifer Keller, Nathan J Young, William W Li
BACKGROUND: Acellular matrices have been successfully used to heal indolent diabetic foot ulcers (DFUs). These tissues include allogenic dermis as well as xenograft dermis, pericardium, and small intestine submucosa. While all of these tissues show promise for healing DFUs, dermal-derived matrices have shown considerable potential. MATERIALS AND METHODS: The authors retrospectively reviewed healing in patients with DFUs that failed the standard of care (SOC) treatment from a previous prospective randomized, controlled trial (RCT)...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28265733/major-complex-abdominal-wall-repair-in-contaminated-fields-with-use-of-a-non-cross-linked-biologic-mesh-a-dual-institutional-experience
#20
J J Atema, E J Furnée, Y Maeda, J Warusavitarne, P J Tanis, W A Bemelman, C J Vaizey, M A Boermeester
BACKGROUND: Data on the use of biologic mesh in abdominal wall repair in complex cases remain sparse. Aim of this study was to evaluate a non-cross-linked porcine acellular dermal matrix for repair of complex contaminated abdominal wall defects. METHODS: Retrospective observational cohort study of consecutive patients undergoing abdominal wall repair with use of Strattice™ Reconstructive Tissue Matrix (LifeCell Corporation, Oxford, UK) between January 2011 and February 2015 at two National Intestinal Failure Units...
March 6, 2017: World Journal of Surgery
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