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https://www.readbyqxmd.com/read/29684901/an%C3%A3-lisis-de-costo-de-la-enfermedad-del-tratamiento-las-complicaciones-e-intervenciones-de-la-hipercolesterolemia-en-m%C3%A3-xico-en-2016
#1
German Baeza-Cruz, Gustavo Peniche-Otero, Mónica E Alva-Esqueda, Mariana Naranjo-Muedano, Noé Soria-Suárez, Héctor J Morales-Flores
OBJETIVOS: Describir los costos y el impacto económico de la atención de pacientes diagnosticados con hipercolesterolemia en México en el año 2016. METODOLOGíA: Se desarrolla una evaluación económica del tipo análisis de costo de la enfermedad donde se cuantifican los recursos médicos utilizados para el tratamiento de la hipercolesterolemia así como para sus complicaciones. Los costos de los recursos médicos utilizados son obtenidos de los costos unitarios por nivel de atención del Instituto Mexicano del Seguro Social (IMSS) así como de las licitaciones publicadas en el portal de compras del IMSS...
April 20, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29684781/effect-of-crumb-rubber-on-the-mechanical-properties-of-crushed-recycled-pavement-materials
#2
Jie Li, Mohammad Saberian, Bao Thach Nguyen
The low-carbon footprint of using recycled construction and demolition (C&D) aggregates in civil engineering infrastructure applications has been considered to be a significant solution for the replacement of conventional pavement aggregates. Investigations regarding the use of crumb rubber in the base and subbase layers of pavement have been well documented. However, information on the effects of crumb rubber and its size within C&D aggregates as the base/subbase layers is still very limited. In this study, crumb rubber with particle sizes ranging from 400 to 600 μm (fine) to 10-15 mm (coarse), 20 mm recycled crushed concrete (RCC), and 20 mm crushed rock (CR) were used...
April 20, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29684147/plasma-and-csf-pharmacokinetics-of-meropenem-in-neonates-and-young-infants-results-from-the-neomero-studies
#3
Eva Germovsek, Irja Lutsar, Karin Kipper, Mats O Karlsson, Tim Planche, Corine Chazallon, Laurence Meyer, Ursula M T Trafojer, Tuuli Metsvaht, Isabelle Fournier, Mike Sharland, Paul Heath, Joseph F Standing
Background: Sepsis and bacterial meningitis are major causes of mortality and morbidity in neonates and infants. Meropenem, a broad-spectrum antibiotic, is not licensed for use in neonates and infants below 3 months of age and sufficient information on its plasma and CSF disposition and dosing in neonates and infants is lacking. Objectives: To determine plasma and CSF pharmacokinetics of meropenem in neonates and young infants and the link between pharmacokinetics and clinical outcomes in babies with late-onset sepsis (LOS)...
April 19, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29683734/six-year-review-of-traumatic-brain-injury-in-a-regional-trauma-unit-demographics-contributing-factors-and-service-provision-in-ireland
#4
Patrick W Owens, Noel P Lynch, Donal P O'Leary, Aoife J Lowery, Michael J Kerin
BACKGROUND: Traumatic brain injury (TBI) represents a significant burden of care for acute surgical services, particularly in the absence of on-site neurosurgical cover or sufficient post-acute rehabilitation facilities. We examine factors contributing to TBI, prolonged lengths of stay (LoS) and implications for hospital resources. Long-term outcomes are assessed. METHODS: This is a retrospective cohort study of patients admitted to a regional trauma unit with TBI from 2008 to 2013...
April 23, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29683388/hematocrit-and-impact-of-transfusion-in-patients-receiving-extracorporeal-life-support
#5
Justyna Swol, Christopher Marschall, Justus T Strauch, Thomas A Schildhauer
INTRODUCTION: Increasing the hematocrit is considered to increase oxygen delivery to the patient, especially when hypoxic conditions exist and the patient may become more stable. The aim of this study was to evaluate the relationship between hematocrit and hospital mortality via subgroup analyses of trauma and non-trauma patients. METHODS: The hospital length of stay (LOS) and LOS in the intensive care unit (ICU) and hospital after extracorporeal life support (ECLS) treatment of 81 patients were analyzed and compared...
April 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29683352/a-long-lasting-oral-preformulation-of-the-angiotensin-ii-at1-receptor-antagonist-losartan
#6
Washington X De Paula, Ângelo M L Denadai, Aline N G Braga, Prasad Shastri, Sérgio V B Pinheiro, Frederic Frezard, Robson A S Santos, Rubén D Sinisterra
Losartan, a nonpeptidic orally active agent, reduces arterial pressure through specific and selective blockade of angiotensin II receptor AT1. However, this widely used AT1 antagonist presents low bioavailability and needs once or twice a day dosage. In order to improve its bioavailability, we used the host:guest strategy based on β-cyclodextrin (βCD). The results suggest that Losartan included in βCD showed a typical pulsatile release pattern after oral administration to rats, with increase of plasma levels of Losartan...
April 23, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29683206/the-effects-of-air-pollution-on-length-of-hospital-stay-for-adult-patients-with-asthma
#7
Li Luo, Jing Ren, Fengyi Zhang, Wei Zhang, Chunyang Li, Zhixin Qiu, Debin Huang
Length of hospital stay (LOS) of asthma can be a reflection of the disease burden faced by patients, and it is also sensitive to air pollution. This study aims at estimating and validating the effects of air pollution and readmission on the LOS for those who have asthma, considering their readmission history, minimum temperature, and threshold effects of air pollutants. In addition, sex, age, and season were also constructed for stratification to achieve more precise and specific results. The results show that no significant effects of PM2...
April 23, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29682984/clinical-and-economic-benefits-of-advanced-microplegia-delivery-system-in-cardiac-surgery-evidence-from-250-hospitals
#8
Marc W Gerdisch, Scott Robinson, Guy David, Stephanie Makepeace, Michael P Ryan, Candace Gunnarsson
AIM: Determine the impact of a second generation microplegia delivery system (MPS2) compared with traditional cardioplegia. Materials &  methods: Multivariable difference-in-differences analysis using fixed effects was performed for each outcome: adverse event (AE) composite, total visit cost, medication cost, length of stay (LOS) and  intensive care unit (ICU) days. RESULTS: A 2.25% absolute risk reduction in AE composite was found with MPS2 compared with traditional cardioplegia, which equates to relative risk reduction of 5...
April 23, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29682212/relationship-between-hospital-volume-and-short-term-outcomes-a-nationwide-population-based-study-including-75-280-rectal-cancer-surgical-procedures
#9
Salvatore Pucciarelli, Manuel Zorzi, Nicola Gennaro, Francesco Marchegiani, Andrea Barina, Massimo Rugge, Matteo Zuin, Alessandro Perin, Isacco Maretto, Francesca Bergamo, Caterina Boso, Emanuele Damiano Luca Urso, Patrick Frambach, Maria Chiara Corti
There is growing interest on the potential relationship between hospital volume (HV) and outcomes as it might justify the centralization of care for rectal cancer surgery. From the National Italian Hospital Discharge Dataset, data on 75,280 rectal cancer patients who underwent elective major surgery between 2002 and 2014 were retrieved and analyzed. HV was grouped into tertiles: low-volume performed 1-12, while high-volume hospitals performed 33+ procedures/year. The impact of HV on in-hospital mortality, abdominoperineal resection (APR), 30-day readmission, and length of stay (LOS) was assessed...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681446/reduction-of-radiography-with-point-of-care-elbow-ultrasonography-for-elbow-trauma-in-children
#10
Julia Tokarski, Jeffrey R Avner, Joni E Rabiner
OBJECTIVES: To determine whether point-of-care elbow ultrasound (US), with history and physical examination, can decrease radiography for patients with elbow trauma. Secondary outcomes included evaluation of pediatric emergency department (PED) length of stay (LOS) and test performance characteristics. STUDY DESIGN: This was a prospective study of patients up to age 21 years with elbow trauma necessitating radiography. After clinical examination and before radiography, pediatric emergency physicians performed elbow ultrasonography of the posterior fat pad and determined whether radiography was required...
April 19, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29681093/low-level-expression-of-epg5-leads-to-an-attenuated-vici-syndrome-phenotype
#11
Megan A Waldrop, Felecia Gumienny, Daniel Boue, Emily de Los Reyes, Richard Shell, Robert B Weiss, Kevin M Flanigan
Vici syndrome is a multisystem disorder characterized by agenesis of the corpus callosum, oculocutaneous hypopigmentation, cataracts, cardiomyopathy, combined immunodeficiency, failure to thrive, profound developmental delay, and acquired microcephaly. Most individuals are severely affected and have a markedly reduced life span. Here we describe an 8-year-old boy with a history of developmental delay, agenesis of the corpus callosum, failure to thrive, myopathy, and well-controlled epilepsy. He was initially diagnosed with a mitochondrial disorder, based in part upon nonspecific muscle biopsy findings, but mitochondrial DNA mutation analysis revealed no mutations...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29680585/functional-and-cognitive-impairment-social-functioning-frailty-and-adverse-health-outcomes-in-older-patients-with-esophageal-cancer-a-systematic-review
#12
Floor J van Deudekom, Henk G Klop, Henk H Hartgrink, Jurjen J Boonstra, Irene M Lips, Marije Slingerland, Simon P Mooijaart
BACKGROUND: Older patients with esophageal cancer are at high risk of adverse health outcomes, but the association of geriatric assessment with adverse health outcomes in these patients has not been systematically evaluated. The aim of this systematic review was to study the association of functional and cognitive impairment, social environment and frailty with adverse health outcomes in patients diagnosed with esophageal cancer. METHODS: We searched Pubmed, Embase, Web of Science and Cochrane Library for original studies reporting on associations of functional or cognitive impairment, social environment and frailty with adverse outcomes (mortality, functional or cognitive decline, adverse events during treatment, prolonged length of hospitalization (LOS) and health related quality of life (HRQoL)) after follow-up in patients with esophageal cancer...
April 18, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29679752/thermodynamic-compatibility-between-cyclodextrin-supramolecular-complexes-and-surfactant
#13
Larissa H R Meira, Guilherme A B Soares, Homero I M Bonomini, Juliana Fedoce Lopes, Frederico B De Sousa
Supramolecular structures based on cyclodextrins have been extensively used for drug delivery systems over decades. However, combining host and guest molecules in a pharmaceutical formulation is not a trivial process, being one of the majors concern the inclusion complex compatibility with other excipients presented in the final formulation. Herein, experimental and theoretical calculations were used to investigate the competition of sodium dodecyl sulfate (SDS) with atenolol (ATE) or losartan (LOS), antihypertensive drugs widely used in the treatment of hypertension...
April 18, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29679116/arthroscopic-treatment-for-intratendinous-rotator-cuff-tear-results-in-satisfactory-clinical-outcomes-and-structural-integrity
#14
Sang Jin Cheon, Hyo Yeol Lee, Woong Ki Jeon
PURPOSE: This study aimed to evaluate the clinical outcomes and structural integrity of arthroscopic repair of intratendinous rotator cuff tear. METHODS: Patients who were diagnosed with an intratendinous tear but in whom conservative treatment failed were selected and underwent arthroscopic repair. Between 2008 and 2014, a total of 30 patients (6 men, 24 women; mean age, 59 ± 3.7 years) met the inclusion criteria and were followed up. The mean follow-up period was 26...
April 20, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29678702/predictive-modeling-of-length-of-hospital-stay-following-adult-spinal-deformity-correction-analysis-of-653-patients-with-an-accuracy-of-75-within-2-days
#15
Michael M Safaee, Justin K Scheer, Tamir Ailon, Justin S Smith, Robert A Hart, Douglas C Burton, Shay Bess, Brian J Neuman, Peter G Passias, Emily Miller, Christopher I Shaffrey, Frank Schwab, Virginie Lafage, Eric O Klineberg, Christopher P Ames
BACKGROUND: Length of stay (LOS) following adult spinal deformity (ASD) surgery is a critical period that allows for optimal recovery. Predictive models that estimate length of stay allow for stratification of high risk patients. METHODS: A prospectively acquired multi-center database of ASD patients was used. Those with staged surgery or LOS>30 days were excluded. Univariable predictor importance ≥0.90, redundancy, and collinearity testing were used to identify variables for model building...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678435/prediction-of-patient-length-of-stay-on-the-intensive-care-unit-following-cardiac-surgery-a-logistic-regression-analysis-based-on-the-cardiac-operative-mortality-risk-calculator-euroscore
#16
Katherine Meadows, Richard Gibbens, Caroline Gerrard, Alain Vuylsteke
OBJECTIVE: The aim of this study was to develop a statistical model based on patient parameters to predict the length of stay (LOS) in the intensive care unit (ICU) following cardiac surgery in a single center. DESIGN: Data were collected from patients admitted to the ICU following cardiac surgery over a 10-year period (2006-2016). Both the additive and logistic EuroSCORE were calculated, and logistic regression analysis was carried out to formulate a model relating the predicted LOS to the EuroSCORE...
March 7, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29677221/a-2015-outbreak-of-flea-borne-rickettsiosis-in-san-gabriel-valley-los-angeles-county-california
#17
Kimberly Nelson, Alice N Maina, Angela Brisco, Chelsea Foo, Curtis Croker, Van Ngo, Rachel Civen, Allen L Richards, Kenn Fujioka, J Wakoli Wekesa
Although flea-borne rickettsiosis is endemic in Los Angeles County, outbreaks are rare. In the spring of 2015 three human cases of flea-borne rickettsiosis among residents of a mobile home community (MHC) prompted an investigation. Fleas were ubiquitous in common areas due to presence of flea-infested opossums and overabundant outdoor cats and dogs. The MHC was summarily abated in June 2015, and within five months, flea control and removal of animals significantly reduced the flea population. Two additional epidemiologically-linked human cases of flea-borne rickettsiosis detected at the MHC were suspected to have occurred before control efforts began...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29677012/inverse-correlation-between-daily-outdoor-temperature-and-blood-pressure-in-six-us-cities
#18
Jennifer M Radin, Daniel Neems, Ross Goglia, Khan Siddiqui, Steven R Steinhubl
This study aims to evaluate the relationship between mean outdoor temperature and mean daily blood pressure (BP) and heart rate (HR) among six, large, geographically and climatically diverse US cities. We collected BP and HR data from Higi stations, located in a wide range of neighborhood grocery stores and retail pharmacies, from six US cities (Houston, Los Angeles, Miami, Boise, Chicago, and New York City). Outdoor daily temperature data were collected from the National Centers for Environmental Information's database...
April 19, 2018: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29676892/multiple-pathways-to-bacterial-load-reduction-by-stormwater-best-management-practices-tradeoffs-in-performance-volume-and-treated-area
#19
Jordyn Wolfand, Colin D Bell, Alexandria B Boehm, Terri Hogue, Richard G Luthy
Stormwater best management practices (BMPs) are implemented to reduce microbial pollution in runoff, but their removal efficiencies differ. Enhanced BMPs, such as those with media amendments, can increase removal of fecal indicator bacteria (FIB) in runoff from 0.25-log10 to above 3-log10 ; however, their implications for watershed-scale management are poorly understood. In this work, a computational model was developed to simulate watershed-scale bacteria loading and BMP performance, using the Ballona Creek Watershed (Los Angeles County, CA) as a case study...
April 20, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29676866/detecci%C3%A3-n-y-expresi%C3%A3-n-de-superant%C3%A3-genos-y-de-resistencia-antimicrobiana-en-aislamientos-obtenidos-de-mujeres-portadoras-de-staphylococcus-aureus-que-cuidan-y-alimentan-ni%C3%A3-os
#20
Yina Marcela Guaca-González, Gladys Fernanda Flórez-Restrepo, José Ignacio Moncayo-Ortíz, Jorge Santacruz-Ibarra, Adalucy Álvarez-Aldana
Introducción. Staphylococcus aureus coloniza mucosas y piel, y causa graves infecciones en el hombre y los animales. Es importante establecer el estatus de portadoras de cepas enterotoxigénicas de este microorganismo en manipuladoras de alimentos, con el fin de prevenir intoxicaciones alimentarias.Objetivo. Establecer las correlaciones entre los genes de enterotoxinas clásicas, el gen tsst-1, la producción de toxinas en cultivo y la resistencia antimicrobiana en aislamientos de S. aureus provenientes de manipuladoras de alimentos que cuidan niños en sus comunidades...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
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