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https://www.readbyqxmd.com/read/29245092/predictors-of-hospitalization-length-of-stay-among-re-admitted-treatment-resistant-bipolar-disorder-inpatients
#1
M Fornaro, F Iasevoli, S Novello, A Fusco, A Anastasia, D De Berardis, A Valchera, A de Bartolomeis
BACKGROUND: Hospitalization accounts for significant health care resource utilization for treatment-resistant Bipolar Disorder (BD), especially among frequent users of acute inpatient psychiatric units. Appraisal of the clinical features and predictive role of selected variables is therefore crucial in such population, representing the aim of the present research. METHODS: A hundred and nineteen BD inpatients with an established history of pharmacological treatment resistance for either mania or bipolar depression were classified as long hospitalization cases (LOS+) and their controls and compared against each other for a number of demographic, clinical, and psychopathological features...
December 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29243100/parents-use-of-complementary-health-approaches-for-young-children-with-autism-spectrum-disorder
#2
Olivia J Lindly, Sheryl Thorburn, Karen Heisler, Nuri M Reyes, Katharine E Zuckerman
Knowledge of why parents use complementary health approaches (CHA) for children with autism spectrum disorder (ASD) is limited. We conducted a mixed methods study to better understand factors influencing parents' decision to use CHA for ASD. Parent-reported data about CHA use were collected on a probability sample of 352 young children with ASD in Denver, Colorado; Los Angeles, California; or Portland, Oregon. Follow-back interviews were conducted with 31 parents. CHA use was negatively associated with older child age and positively associated with parents' belief ASD has major consequences, living in Portland or Denver, and medication use...
December 14, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29242243/an-infrared-dye-conjugated-virus-like-particle-for-the-treatment-of-primary-uveal-melanoma
#3
Rhonda C Kines, Isabella Varsavsky, Sanghamitra Choudhary, Debaditya Bhattacharya, Sean Spring, Roger J McLaughlin, Shin J Kang, Hans E Grossniklaus, Demitrios G Vavvas, Stephen Monks, John R MacDougall, Elisabet de Los Pinos, John T Schiller
The work outlined herein describes AU-011, a novel recombinant papillomavirus-like particle (VLP) drug conjugate and its initial evaluation as a potential treatment for primary uveal melanoma. The VLP is conjugated with a phthalocyanine photosensitizer, IRDye 700DX, that exerts its cytotoxic effect through photo-activation with a near-infrared laser. We assessed the anti-cancer properties of AU-011 in vitro utilizing a panel of human cancer cell lines and in vivo using murine subcutaneous and rabbit orthotopic xenograft models of uveal melanoma...
December 14, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29241966/streptococcus-anginosus-is-associated-with-postoperative-intraabdominal-collections-in-appendicitis
#4
Thejasvi Subramanian, Ellen Jerome, Ian Jones, Ingo Jester
AIM OF STUDY: Streptococcus anginosus group (SA) (formerly Streptococcus milleri) are pathogens recognised to have a high risk of postoperative collection in appendicitis, although little data exist specifically in children. We performed a retrospective review of all microbiological data from appendicectomies to assess whether there was an association in children. METHODS: A retrospective case note review of patients admitted to a paediatric tertiary centre coded for appendicitis from January 2015 to October 2016 was completed...
November 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29241958/time-to-appendectomy-for-acute-appendicitis-a-systematic-review
#5
REVIEW
Danielle B Cameron, Regan Williams, Yimin Geng, Ankush Gosain, Meghan A Arnold, Yigit S Guner, Martin L Blakely, Cynthia D Downard, Adam B Goldin, Julia Grabowski, Dave R Lal, Roshni Dasgupta, Robert Baird, Robert L Gates, Julia Shelton, Tim Jancelewicz, Shawn J Rangel, Mary T Austin
OBJECTIVE: The goal of this systematic review by the American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee was to develop recommendations regarding time to appendectomy for acute appendicitis in children within the context of preventing adverse events, reducing cost, and optimizing patient/parent satisfaction. METHODS: The committee selected three questions that were addressed by searching MEDLINE, Embase, and the Cochrane Library databases for English language articles published between January 1, 1970 and November 3, 2016...
November 20, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29241943/gender-disparities-in-park-use-and-physical-activity-among-residents-of-high-poverty-neighborhoods-in-los-angeles
#6
Kathryn P Derose, Bing Han, Stephanie Williamson, Deborah A Cohen
INTRODUCTION: Physical inactivity is more prevalent among women than men and is related to poor health outcomes. Neighborhood parks constitute an important resource for physical activity (PA), however, previous studies of park users have found fewer women being physically active. METHODS: We conducted a hierarchical mixed-effect regression analysis of the independent associations between gender and park use and PA among a population-based sample in high-poverty neighborhoods in Los Angeles...
December 11, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29241342/evaluating-the-impact-of-the-addition-of-cladribine-to-standard-acute-myeloid-leukemia-induction-therapy
#7
Nathan D Seligson, Athena L V Hobbs, Joanna M Leonard, Elizabeth L Mills, Amy G Evans, Salil Goorha
BACKGROUND: Treatment for acute myeloid leukemia (AML) has remained relatively unchanged over the past few decades. Although recent drug approvals have provided an increase in the number of treatment options in AML, further optimization of standard induction therapy is still necessary. The most commonly utilized induction options have been well studied, but there is a paucity of literature comparing the combination of idarubicin with cytarabine and cladribine. OBJECTIVE: To assess the clinical effectiveness of the addition of cladribine to idarubicin and cytarabine (7+3 IA) induction therapy in the treatment of AML...
December 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29241167/nutritional-screening-and-clinical-outcome-in-hospitalized-patients-with-crohn-s-disease
#8
Azusa Takaoka, Masaya Sasaki, Naoko Nakanishi, Mika Kurihara, Akiko Ohi, Shigeki Bamba, Akira Andoh
BACKGROUND/AIMS: Hospitalized patients with Crohn's disease (CD) can develop severe nutritional deficits. However, the nutritional screening tools with the most utility for such patients are still unknown. METHODS: Nutritional status of 40 CD patients was assessed on admission using several screening tools and laboratory tests. Their validity was evaluated in relation to length of hospital stay (LOS) and intestinal resection. Receiver operating characteristic analysis was performed to predict prolonged LOS (≥28 days)...
December 14, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29239963/in-vitro-evaluation-of-a-novel-image-processing-device-to-estimate-surgical-blood-loss-in-suction-canisters
#9
Gerhardt Konig, Jonathan H Waters, Eric Hsieh, Bridget Philip, Vicki Ting, Gaurav Abbi, Mazyar Javidroozi, Griffeth W Tully, Gregg Adams
BACKGROUND: Clinicians are tasked with monitoring surgical blood loss. Unfortunately, there is no reliable method available to assure an accurate result. Most blood lost during surgery ends up on surgical sponges and within suction canisters. A novel Food and Drug Administration-cleared device (Triton system; Gauss Surgical, Inc, Los Altos, CA) to measure the amount of blood present on sponges using computer image analysis has been previously described. This study reports on performance of a complementary Food and Drug Administration-cleared device (Triton Canister System; Gauss Surgical, Inc, Los Altos, CA) that uses similar image analysis to measure the amount of blood in suction canisters...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29239831/factors-associated-with-in-hospital-mortality-among-critically-ill-surgical-patients-with-multidrug-resistant-gram-negative-infections
#10
Andrew S Jarrell, Rachel M Kruer, Loredana Diana Berescu, Peter J Pronovost, Julie B Trivedi
PURPOSE: Multidrug-resistant (MDR) Gram-negative infection increases risk of mortality, other complications, and costs. The objective of this study was to determine the prevalence of and identify factors associated with in-hospital mortality among critically ill surgical patients. MATERIALS AND METHODS: This case-control study included critically ill surgical patients from 2011 to 2014 who had a carbapenem-resistant Enterobacteriaceae (CRE), MDR P. aeruginosa, or MDR Acinetobacter spp...
November 24, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29239829/marked-elevation-of-circulating-cd19-cd38hicd24hi-transitional-b-cells-give-protection-against-neonatal-sepsis
#11
Sitao Li, Fei Ma, Hu Hao, Desheng Wang, Yu Gao, Jialiang Zhou, Fei Li, Hung-Chih Lin, Xin Xiao, Qiyi Zeng
BACKGROUND: Adequate functions of immunoregulation, mediated by regulatory cells such as IL-10 producing CD19+CD38hiCD24hi transitional B cells (Trans), play an important role in control of excessive inflammatory response. Yet, the role of Trans in neonatal sepsis is incompletely understood. We investigated the role of Trans in late-onset sepsis (LOS). METHODS: We used multicolor flow cytometry to analyse the phenotypes of B cells drawn from a cohort of 16 neonatal late-onset sepsis (LOS) (12 survivors and 4 non-survivors) and 20 healthy neonates over time...
October 19, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29239823/getting-hiv-self-test-kits-into-the-home-for-young-african-american-msm-in-los-angeles-a-qualitative-report
#12
Joseph Daniels, Robert Marlin, Alex Medline, Greg Wilson, Sean Young, Lina Rosengren, Emily Huang, Jeffrey D Klausner
No abstract text is available yet for this article.
October 10, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/29238657/30-day-adverse-event-rates-following-penile-prosthesis-surgery-an-american-college-of-surgeons-national-surgical-quality-improvement-program-based-evaluation
#13
Isaac Palma-Zamora, Akshay Sood, Ali A Dabaja
Background: Commonly utilized as a third-line therapy for erectile dysfunction (ED) management, the penile prostheses have become a staple treatment for ED refractory to pharmacological interventions. There is however a paucity of data in the literature pertaining to short-term adverse outcomes following penile prosthesis surgery. We thus sought to leverage the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) to evaluate such outcomes within 30 days of surgery in these patients...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29238640/high-risk-subgroup-membership-is-a-predictor-of-30-day-morbidity-following-anterior-lumbar-fusion
#14
Rachel S Bronheim, Jun S Kim, John Di Capua, Nathan J Lee, Parth Kothari, Sulaiman Somani, Kevin Phan, Samuel K Cho
Study Design: Retrospective cohort study. Objective: To determine if membership in a high-risk subgroup is predictive of morbidity and mortality following anterior lumbar fusion (ALF). Methods: The American College of Surgeons National Surgical Quality Improvement Program database was utilized to identify patients undergoing ALF between 2010 and 2014. Multivariate analysis was utilized to identify high-risk subgroup membership as an independent predictor of postoperative complications...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29238631/ethnic-and-age-disparities-in-patients-taking-long-acting-injectable-atypical-antipsychotics
#15
Mateen Soleman, Nikki Lam, Benjamin K Woo
Introduction This study will determine whether different ethnicities and different age groups receive equal amounts of long-acting atypical antipsychotics in comparison to their oral equivalents. Methods Secondary analyses of data from the Los Angeles County Department of Health Services Electronic Health Record (total N=63,134 inpatient visits) were performed. Chi-squared statistics were used to compare ethnicity and age with the use of either risperidone injectable or paliperidone palmitate (r-LAIs) versus risperidone oral...
October 12, 2017: Curēus
https://www.readbyqxmd.com/read/29237289/safely-converting-an-entire-academic-medical-center-from-sliding-scale-to-basal-bolus-insulin-via-implementation-of-the-eglycemic-management-system
#16
Rosalina Newsom, Christopher Patty, Emma Camarena, Regina Sawyer, Raymie McFarland, Thomas Gray, Melanie Mabrey
OBJECTIVE: Hyperglycemia is common in the inpatient setting and providers frequently rely on sliding scale insulin. This case study reviews the experience of one hospital moving from high utilization of sliding scale to basal bolus insulin therapy. METHOD: This Retrospective Quality Improvement Study describes the journey of clinicians at a 580-bed hospital to convert from high usage of SSI to BBI. Hyperglycemic adult patients prescribed insulin, with/without a diagnosis of diabetes, were included...
December 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29237135/spontaneous-pneumothorax-in-children-national-management-strategies-and-outcomes
#17
Kibileri Williams, Tolulope A Oyetunji, Grace Hsuing, Richard J Hendrickson, Timothy B Lautz
INTRODUCTION: The timing of surgical intervention in the management of spontaneous pneumothorax remains controversial. The aim of this multicenter review was to compare management strategies and outcomes in children with spontaneous pneumothorax. METHODS: We retrospectively reviewed patients 10-19 years old in the Pediatric Health Information System admitted for spontaneous pneumothorax from 2010 to 2014. Three treatment groups were identified based on initial hospital management-no intervention, initial chest tube placement, and operation; and outcomes were compared...
December 13, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29237009/recent-trends-in-chemotherapy-use-and-oncologists-treatment-recommendations-for-early-stage-breast-cancer
#18
Allison W Kurian, Irina Bondarenko, Reshma Jagsi, Christopher R Friese, M Chandler McLeod, Sarah T Hawley, Ann S Hamilton, Kevin C Ward, Timothy P Hofer, Steven J Katz
Background: There is growing concern about overtreatment of breast cancer as outcomes have improved over time. However, little is known about how chemotherapy use and oncologists' recommendations have changed in recent years. Methods: We surveyed 5080 women (70% response rate) diagnosed with breast cancer between 2013 and 2015 and accrued through two Surveillance, Epidemiology, and End Results registries (Georgia and Los Angeles) about chemotherapy receipt and their oncologists' chemotherapy recommendations...
December 11, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29236843/weakness-acquired-in-the-intensive-care-unit-incidence-risk-factors-and-their-association-with-inspiratory-weakness-observational-cohort-study
#19
Ladislao Pablo Diaz Ballve, Nahuel Dargains, José García Urrutia Inchaustegui, Antonella Bratos, Maria de Los Milagros Percaz, Cesar Bueno Ardariz, Sabrina Cagide, Carolina Balestrieri, Claudio Gamarra, Dario Paz, Eliana Rotela, Sebastian Muller, Fernando Bustos, Ricard Aranda Castro, Esteban Settembrino
OBJECTIVE: This paper sought to determine the accumulated incidence and analyze the risk factors associated with the development of weakness acquired in the intensive care unit and its relationship to inspiratory weakness. METHODS: We conducted a prospective cohort study at a single center, multipurpose medical-surgical intensive care unit. We included adult patients who required mechanical ventilation ≥ 24 hours between July 2014 and January 2016. No interventions were performed...
December 7, 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29236627/structural-factors-affecting-asians-and-pacific-islanders-in-community-based-substance-use-treatment-treatment-provider-perspectives
#20
Jamie Suki Chang, James L Sorensen, Carmen L Masson, Michael S Shopshire, Kim Hoffman, Dennis McCarty, Martin Iguchi
Asians and Pacific Islanders (API) have large disparities in utilization of substance use treatment compared to other racial groups. In this study, we analyzed factors that shape API experiences accessing and engaging in community-based treatment from the perspective of treatment providers. We conducted semi-structured interviews with 40 treatment providers who work with API clients in treatment programs in San Francisco and Los Angeles. We analyzed the transcribed interview data in ATLAS.ti using a content analysis approach...
October 2017: Journal of Ethnicity in Substance Abuse
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