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Diabetic peripheral neuropathy

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https://www.readbyqxmd.com/read/29770116/peripheral-glial-cells-in-the-development-of-diabetic-neuropathy
#1
REVIEW
Nádia Pereira Gonçalves, Christian Bjerggaard Vægter, Lone Tjener Pallesen
The global prevalence of diabetes is rapidly increasing, affecting more than half a billion individuals within the next few years. As diabetes negatively affects several physiological systems, this dramatic increase represents not only impaired quality of life on the individual level but also a huge socioeconomic challenge. One of the physiological consequences affecting up to half of diabetic patients is the progressive deterioration of the peripheral nervous system, resulting in spontaneous pain and eventually loss of sensory function, motor weakness, and organ dysfunctions...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29763613/neuroprotective-effect-of-duloxetine-in-a-mouse-model-of-diabetic-neuropathy-role-of-glia-suppressing-mechanisms
#2
Mona K Tawfik, Seham A Helmy, Dahlia I Badran, Sawsan A Zaitone
AIMS: Painful diabetic neuropathy (PDN) is one of the most frequent complications of diabetes and the current therapies have limited efficacy. This study aimed to study the neuroprotective effect of duloxetine, a serotonin noradrenaline reuptake inhibitor (SNRI), in a mouse model of diabetic neuropathy. MAIN METHODS: Nine weeks after developing of PDN, mice were treated with either saline or duloxetine (15 or 30 mg/kg) for four weeks. The effect of duloxetine was assessed in terms of pain responses, histopathology of sciatic nerve and spinal cord, sciatic nerve growth factor (NGF) gene expression and on the spinal expression of astrocytes (glial fibrillary acidic protein, GFAP) and microglia (CD11 b)...
May 12, 2018: Life Sciences
https://www.readbyqxmd.com/read/29754759/exercise-to-improve-diabetic-peripheral-neuropathy-an-additional-option
#3
EDITORIAL
Prashanth R J Vas, Kalliopi Pafili, Nikolaos Papanas
No abstract text is available yet for this article.
May 10, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29754274/neuroprotective-and-antinociceptive-effects-of-rosemary-rosmarinus-officinalis-l-extract-in-rats-with-painful-diabetic-neuropathy
#4
Bahram Rasoulian, Zahra Hajializadeh, Saeed Esmaeili-Mahani, Marzieh Rashidipour, Iman Fatemi, Ayat Kaeidi
Diabetes mellitus is associated with the development of neuronal tissue damage in different central and peripheral nervous system regions. A common complication of diabetes is painful diabetic peripheral neuropathy. We have explored the antihyperalgesic and neuroprotective properties of Rosmarinus officinalis L. extract (RE) in a rat model of streptozotocin (STZ)-induced diabetes. The nociceptive threshold and motor coordination of these diabetic rats was assessed using the tail-flick and rotarod treadmill tests, respectively...
May 12, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29753996/risk-factors-for-diabetic-foot-ulcer-recurrence-a-prospective-2-year-follow-up-study-in-egypt
#5
Walaa A Khalifa
OBJECTIVES: To determine the frequency of diabetic foot ulcer recurrence and its potential risk factors. METHODS: This study included 93 patients with type 2 diabetes and followed for 2 years after primary healed foot ulceration. Demographic, diabetes related, comorbid and ulcer related variables were investigated as risk factors. Multiple logistic regression analysis was used to identify independent risk factors. RESULTS: 61.3% of patients had recurrent ulcers particularly in the forefoot (33...
December 28, 2017: Foot
https://www.readbyqxmd.com/read/29750992/transcriptome-analysis-of-dorsal-root-ganglia-s-diabetic-neuropathy-reveals-mechanisms-involved-in-pain-and-regeneration
#6
Maria Carolina Pedro Athie, Andre Schwambach Vieira, Juliana Maia Teixeira, Gilson Gonçalves Dos Santos, Elayne Vieira Dias, Claudia Herrera Tambeli, Cesar Renato Sartori, Carlos A Parada
Peripheral diabetic neuropathy (DN) manifests in nearly 60% of diabetic patients, being pain its most debilitating symptom. Although electrophysiological and morphological aspects are well described, little is known about its development and progression, undermining effective therapies. Hyperglycemia and insulin signaling impairment are considered the triggering events of oxidative stress observed in the dying nerves, however there are still many gaps in the knowledge of intracellular plastic changes it generates...
May 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/29750054/how-do-patients-with-diabetes-report-their-comorbidities-comparison-with-administrative-data
#7
Jonas Hoffmann, Burkhard Haastert, Manuela Brüne, Matthias Kaltheuner, Alexander Begun, Nadja Chernyak, Andrea Icks
Aims: Patients with diabetes are probably often unaware of their comorbidities. We estimated agreement between self-reported comorbidities and administrative data. Methods: In a random sample of 464 diabetes patients, data from a questionnaire asking about the presence of 14 comorbidities closely related to diabetes were individually linked with statutory health insurance data. Results: Specificities were >97%, except cardiac insufficiency (94...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29750001/effect-of-combined-dyslipidemia-and-hyperglycemia-on-diabetic-peripheral-neuropathy-in-alloxan-induced-diabetic-wbn-kob-rats
#8
Kiyokazu Ozaki, Yui Terayama, Tetsuro Matsuura, Isao Narama
Clinical and experimental research have suggested that dyslipidemia aggravates diabetic peripheral neuropathy (DPN). However, whether dyslipidemia is a risk factor for DPN remains unclear. To investigate the effect of dyslipidemia on DPN, morphological features of peripheral nerves were analyzed in diabetic rats treated with a high-fat diet (HFD). Male rats were divided into four groups: nondiabetic rats (N), alloxan-induced diabetic rats (AL), diabetic rats treated with an HFD (AH), and nondiabetic rats treated with an HFD (HF)...
April 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29749662/high-resolution-nerve-ultrasound-and-electrophysiological-findings-in-restless-legs-syndrome
#9
K Pitarokoili, M Fels, A Kerasnoudis, L Toenges, R Gold, M-S Yoon
BACKGROUND AND PURPOSE: Restless legs syndrome (RLS) is a multifactorial network disorder of a sensorimotor system extending from dopaminergic and glutamatergic cerebral structures to the spinal neurons and peripheral nerves. The role of peripheral nerve damage in the causality and severity progression for RLS patients remains unclear. METHODS: We performed a clinical and epidemiological study on a cohort of 34 RLS patients focusing on RLS risk factors and disease severity...
May 11, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29749025/photobiomodulation-induces-antinociception-recovers-structural-aspects-and-regulates-mitochondrial-homeostasis-in-peripheral-nerve-of-diabetic-mice
#10
Victória Regina da Silva de Oliveira, Diego Pulzatto Cury, Laura Basílio Yamashita, Marcos Vinicius Esteca, Ii-Sei Watanabe, Yoko Fee Bergmann, Elaine Flamia Toniolo, Camila Squarzoni Dale
Diabetic Peripheral Neuropathy (DPN) is a nervous disorder caused by diabetes mellitus, affecting about 50% of patients in clinical medicine. Chronic pain is one of the major and most unpleasant symptoms developed by those patients, and conventional available treatments for the neuropathy, including the associated pain, are still unsatisfactory and benefit only a small number of patients. Photobiomodulation (PBM) has been gaining clinical acceptance once it is able to promote early nerve regeneration resulting in significant improvement peripheral nerves disabilities...
May 11, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29746890/use-of-a-capillary-alginate-gel-capgel%C3%A2-to-study-the-three-dimensional-development-of-sensory-nerves-reveals-the-formation-of-a-rudimentary-perineurium
#11
Wesley A Anderson, Alicia R Willenberg, Alexander J Bosak, Bradley J Willenberg, Stephen Lambert
BACKGROUND: Peripheral neuropathies affect approximately 20 million people in the United States and often stem from other chronic conditions, such as diabetes. In vitro methodologies to facilitate the understanding and treatment of these disorders often lack the cellular and functional complexity required to accurately model peripheral neuropathies. In particular, they are often 2D and fail to faithfully reproduce the 3D in vivo microenvironment. NEW METHOD: Embryonic dorsal root ganglion (DRG) explants were inserted into laminin derivatized capillary alginate gel (Capgel™), a bioabsorbable, self-assembling biomaterial, possessing parallel microchannel architecture, and cultured to mimic normal nerve development, including Schwann cell myelination...
May 7, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29745916/fournier-s-gangrene-a-rare-complication-of-diabetes-mellitus-case-report
#12
Sh Muharremi
The presented case reports on 54-years old patient with T2 Diabetes mellitus who, due to hypoglycemic episodes on Insulin therapy, was treated with oral anti-hyperglycemic medications. Patient was on hemodialysis due to the stage 5 chronic kidney failure and had various comorbid conditions: arterial hypertension, history of acute myocardial infarction, dilative cardiomyopathy, amaurosis and peripheral neuropathy. Besides his complicated medical history, patient developed an early stage of Fournier's gangrene...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29745908/local-use-of-granulocyte-macrophages-colony-stimulating-factor-in-treatment-of-chronic-diabetic-neuropathic-ulcer-case-review
#13
E Karlafti, Ch Savopoulos, A Hatzitolios, T Didangelos
One of the main causes of amputations in patients with Diabetes Mellitus patients is a chronic diabetic foot ulcer. The authors present a clinical case and discussion of a successful use of Granulocyte-Macrophages Colony Stimulating Factor (GM-CSF) treatment for the promotion of healing of a chronic diabetic foot ulcer. A 65 year-old woman was admitted to the Diabetes Center with complaints of a deep non-healing chronic foot ulcer for the last 18 months. At the examination a 5 cm ulcer on the plantar surface of the right foot was revealed...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29737807/association-of-vitamin-d-deficiency-with-diabetic-peripheral-neuropathy-and-diabetic-nephropathy-in-tianjin-china
#14
Leping Fan, Yue Zhang, Jie Zhu, Yixuan Song, Jingna Lin
BACKGROUND AND OBJECTIVES: To evaluate the association of vitamin D deficiency with type 2 diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN). METHODS AND STUDY DESIGN: A total of 287 type 2 diabetic patients were categorized in two ways, and each divided into two groups: DPN (n=164) and non-DPN (NDPN) groups (n=123); and DN (n=148) and non-DN (NDN) groups (n=139). Enzyme-linked immunosorbent assay was used to measure the 25-hydroxy vitamin D [25(OH)D3] level...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29736880/comparison-of-peripheral-nerve-protection-between-insulin-based-glucose-control-and-alpha-lipoic-acid-ala-in-the-streptozotocin-stz-induced-diabetic-rat
#15
Kyung Ae Lee, Na Young Lee, Tae Sun Park, Heung Yong Jin
Strict glucose control is a well-proven therapeutic approach for peripheral neuropathies in patients with diabetes. Alpha lipoic acid (ALA) has also been accepted as a therapeutic agent for diabetic peripheral neuropathy (DPN) in the respect of pathogenesis. However, the potential of ALA as a treatment for DPN in comparison to that of glucose control is unclear. In this study, we compared the neuroprotective potential of glucose control and ALA. Animals were divided into 6 groups based on the intervention used, as follows: normal, diabetes (DM), DM+racemic form of ALA, DM+R form of ALA, DM+once daily insulin glargine, and DM+once daily insulin glargine with twice daily insulin glulisine...
May 7, 2018: Endocrine
https://www.readbyqxmd.com/read/29736170/susceptible-and-prognostic-genetic-factors-associated-with-diabetic-peripheral-neuropathy-a-comprehensive-literature-review
#16
REVIEW
L B L Prabodha, N D Sirisena, V H W Dissanayake
Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in approximately 50% of diabetic patients. It is the primary cause of diabetes-related hospital admissions and nontraumatic foot amputations. The pathogenesis of diabetic neuropathy is a complex process that involves hyperglycemia-induced oxidative stress and altered polyol metabolism that changes the nerve microvasculature, altered growth factor support, and deregulated lipid metabolism...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29735963/acupuncture-combined-with-hydrotherapy-in-diabetes-patients-with-mild-lower-extremity-arterial-disease-a-prospective-randomized-nonblinded-clinical-study
#17
Zhengqin Qi, Yan Pang, Lin Lin, Bing Zhang, Juntao Shao, Xiaodong Liu, Xin Zhang
BACKGROUND The aim of this pragmatic study was to explore the intervention of acupuncture combined with hydrotherapy and perceived effects in type 2 diabetic patients with recently diagnosed, mild, lower-extremity arterial disease (LEAD) in comparison with a control group. MATERIAL AND METHODS One hundred twenty-six diabetes patients who were diagnosed mild LEAD according to ankle-brachial blood pressure index (ABPI) and peripheral neuropathy symptom were randomly assigned to either an experimental (n=64) or control group (n=62)...
May 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29726089/diabetic-foot-syndrome-dfs-in-patients-with-diabetes-a-multicenter-german-austrian-dpv-analysis-on-33-870-dfs-patients-among-358-986-adult-subjects-with-diabetes
#18
Barbara Bohn, Arthur Grünerbel, Marcus Altmeier, Carsten Giesche, Martin Pfeifer, Christian Wagner, Nikolai Heise, Frank Best, Peter Fasching, Reinhard W Holl
AIMS: The diabetic foot syndrome (DFS) is a serious complication in patients with diabetes increasing the risk for minor/major amputations. This analysis aimed to examine differences in diabetes patients with or without DFS stratified by type 1 (T1D) or type 2 diabetes (T2D). MATERIAL AND METHODS: Adult patients (≥20y of age) with diabetes from the German/Austrian DPV-registry were included. The cross-sectional study comprised 45,722 subjects with T1D (nDFS =2,966) and 313,264 with T2D (nDFS =30,904)...
May 3, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29725581/a-high-ankle-brachial-index-is-associated-with-obesity-and-low-serum-25-hydroxyvitamin-d-in-patients-with-diabetes
#19
Barbara Depczynski, Tamara Young, Christopher White
Peripheral artery disease (PAD), when present with diabetes, is associated with significant morbidity and mortality. The spectrum of PAD in diabetes includes atherosclerosis with stenotic disease; and diffuse medial calcification with non-compliant arteries, as reflected by high ankle brachial index. The clinical characteristics of a high ABI are less well characterized than that of low ABI. The aim of this study was to determine the unique clinical phenotype of patients with diabetes who have high ankle brachial index (ABI) reading...
March 2018: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29721019/establishing-differences-in-thermographic-patterns-between-the-various-complications-in-diabetic-foot-disease
#20
Alfred Gatt, Owen Falzon, Kevin Cassar, Christian Ellul, Kenneth P Camilleri, Jean Gauci, Stephen Mizzi, Anabelle Mizzi, Cassandra Sturgeon, Liberato Camilleri, Nachiappan Chockalingam, Cynthia Formosa
Aim: To evaluate the potential of thermography as an assessment tool for the detection of foot complications by understanding the variations in temperature that occur in type 2 diabetes mellitus (DM). Methods: Participants were categorized according to a medical examination, ankle brachial index, doppler waveform analysis, and 10-gram monofilament testing into five groups: healthy adult, DM with no complications, DM with peripheral neuropathy, DM with neuroischaemia, and DM with peripheral arterial disease (PAD) groups...
2018: International Journal of Endocrinology
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