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Michelle Wong, Esther Bejarano, Graeme Carvlin, Katie Fellows, Galatea King, Humberto Lugo, Michael Jerrett, Dan Meltzer, Amanda Northcross, Luis Olmedo, Edmund Seto, Alexa Wilkie, Paul English
Air pollution continues to be a global public health threat, and the expanding availability of small, low-cost air sensors has led to increased interest in both personal and crowd-sourced air monitoring. However, to date, few low-cost air monitoring networks have been developed with the scientific rigor or continuity needed to conduct public health surveillance and inform policy. In Imperial County, California, near the U.S./Mexico border, we used a collaborative, community-engaged process to develop a community air monitoring network that attains the scientific rigor required for research, while also achieving community priorities...
March 15, 2018: International Journal of Environmental Research and Public Health
Amanda T Parrish, Kristen Hammerback, Peggy A Hannon, Caitlin Mason, Michelle N Wilkie, Jeffrey R Harris
OBJECTIVE: The aim of this study was to identify alignments between wellness offerings low socioeconomic status (SES) employees need and those large companies can provide. METHODS: Focus groups (employees); telephone interviews (large companies). Employees were low-SES, insured through their employers, and employed by large Washington State companies. Focus groups covered perceived barriers to healthy behaviors at work and potential support from companies. Interviews focused on priorities for employee health and challenges reaching low-SES employees...
March 13, 2018: Journal of Occupational and Environmental Medicine
Vaia Florou, Breelyn A Wilky
Angiosarcomas are rare vascular neoplasms that are among the most aggressive subtypes of soft tissue sarcomas. Surgical resection is often challenging even in localized disease, as the infiltrative nature of these cancers leads to frequent local and metastatic recurrences. Cytotoxic chemotherapy, including anthracycline-based regimens and taxanes can produce significant responses in a subset of patients but durability is limited with most patients ultimately succumbing to metastatic disease. Targeted therapy with tyrosine kinase inhibitors is usually well-tolerated but prone to development of resistance...
March 8, 2018: Current Treatment Options in Oncology
Santhosh A Upadhyaya, Rose B McGee, Breelyn A Wilky, Alberto Broniscer
Malignant progression of a benign or low-grade tumor in individuals with germline alteration of SMARCB1 gene is not well characterized. In a family in which two carrier children had germline SMARCB1 mutations and atypical teratoid rhabdoid tumor, we report malignant progression of a nerve sheath tumor over a 7-year period in an affected adult family member. Prompt identification of the germline SMARCB1 alteration and the resultant rhabdoid tumor predisposition syndrome can help guide genetic counseling and surveillance in affected family members...
March 7, 2018: Pediatric Blood & Cancer
Keesha L Roach, Patricia E Hershberger, Julienne N Rutherford, Robert E Molokie, Zaijie Jim Wang, Diana J Wilkie
Pain is the quintessential symptom for individuals suffering from sickle cell disease (SCD). Although the degree of suffering and the cost of treatment are staggering, SCD continues to be grossly understudied, including a lack of data for pain-related genes and prevalence of polymorphisms in this population. This lack of data adds to the inadequacy of pain therapy in this population. Pain genetics investigators have recently examined allele frequencies of single-nucleotide polymorphisms from candidate genes in people who have SCD...
March 1, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
Miriam O Ezenwa, Robert E Molokie, Zaijie Jim Wang, Yingwei Yao, Marie L Suarez, Brenda Dyal, Khulud Abudawood, Diana J Wilkie
Patients with sickle cell disease (SCD) report pain scores that appear greater than those reported in a meta-analysis for patients with cancer, but statistical comparisons of the pain scores from both populations have not been published. The goal of the study described here was to compare pain outcomes reported by outpatients with cancer or SCD. Descriptive comparative study. Outpatient oncology or sickle cell clinics. The participants were outpatients (N = 415) from three studies: (1) 106 patients with SCD, 93% African-American (referent group); (2) 140 patients with cancer, 90% Caucasian (race discordant); (3) 169 patients with cancer, 20% Caucasian, 65% African-American (race concordant)...
February 28, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
James E M Watson, Tom Evans, Oscar Venter, Brooke Williams, Ayesha Tulloch, Claire Stewart, Ian Thompson, Justina C Ray, Kris Murray, Alvaro Salazar, Clive McAlpine, Peter Potapov, Joe Walston, John G Robinson, Michael Painter, David Wilkie, Christopher Filardi, William F Laurance, Richard A Houghton, Sean Maxwell, Hedley Grantham, Cristián Samper, Stephanie Wang, Lars Laestadius, Rebecca K Runting, Gustavo A Silva-Chávez, Jamison Ervin, David Lindenmayer
As the terrestrial human footprint continues to expand, the amount of native forest that is free from significant damaging human activities is in precipitous decline. There is emerging evidence that the remaining intact forest supports an exceptional confluence of globally significant environmental values relative to degraded forests, including imperilled biodiversity, carbon sequestration and storage, water provision, indigenous culture and the maintenance of human health. Here we argue that maintaining and, where possible, restoring the integrity of dwindling intact forests is an urgent priority for current global efforts to halt the ongoing biodiversity crisis, slow rapid climate change and achieve sustainability goals...
February 26, 2018: Nature Ecology & Evolution
Sara Catarino Santos, Ana Rita Loureiro, Rosa Simão, Jorge Pereira, Luís Filipe Pinheiro, Carlos Casimiro
Wilkie's syndrome, or superior mesenteric artery syndrome (SMAS), is a rare clinical entity caused by compression of the third portion of the duodenum between the abdominal aorta and superior mesenteric artery, leading to duodenal obstruction and severe malnutrition. The authors report a case of a female patient with years of chronic intestinal obstruction with abdominal pain, vomits and weight loss. Contrast intestinal series showed dilation of stomach and duodenum. Abdominal computed tomography study revealed findings compatible with SMAS...
February 2018: Journal of Surgical Case Reports
Svetlana Dolgova, Brian N Popp, Kevin Courtoreille, Rick H M Espie, Bruce Maclean, Mark McMaster, Jason R Straka, Gerald R Tetreault, Steve Wilkie, Craig E Hebert
Levels of biomagnifying contaminants are greatest in high trophic level biota, e.g. predatory birds such as gulls. Gull eggs have been used to assess contaminant spatial patterns and sources but such assessments must consider how organism trophic position may influence spatial inferences. Stable nitrogen isotopes (δ 15 N) in bulk tissue are routinely used in this context. However, bulk δ 15 N values are only useful if spatial differences in baseline δ 15 N values are considered. Amino acid-compound specific stable nitrogen isotope analysis (AA-CSIA) can generate estimates of baseline and trophic position δ 15 N from the same sample...
February 15, 2018: Environmental Toxicology and Chemistry
Hannah J Wilkie, Martyn Standage, Fiona B Gillison, Sean P Cumming, Peter T Katzmarzyk
OBJECTIVES: Physical activity (PA) can provide numerous physical and psychological health gains, yet a low proportion of children in England are sufficiently active to accrue benefit. Analysing the correlates of PA from a socioecological perspective may help to identify factors that promote versus discourage PA. The purpose of the present study was to: (1) assess the relationships between a wide range of potential correlates and intensity-specific PA and (2) explore which correlates are associated with meeting government PA guidelines...
February 3, 2018: BMJ Open
Georgia Vasileiou, Silvia Vergarajauregui, Sabine Endele, Bernt Popp, Christian Büttner, Arif B Ekici, Marion Gerard, Nuria C Bramswig, Beate Albrecht, Jill Clayton-Smith, Jenny Morton, Susan Tomkins, Karen Low, Astrid Weber, Maren Wenzel, Janine Altmüller, Yun Li, Bernd Wollnik, George Hoganson, Maria-Renée Plona, Megan T Cho, Christian T Thiel, Hermann-Josef Lüdecke, Tim M Strom, Eduardo Calpena, Andrew O M Wilkie, Dagmar Wieczorek, Felix B Engel, André Reis
Variants affecting the function of different subunits of the BAF chromatin-remodelling complex lead to various neurodevelopmental syndromes, including Coffin-Siris syndrome. Furthermore, variants in proteins containing PHD fingers, motifs recognizing specific histone tail modifications, have been associated with several neurological and developmental-delay disorders. Here, we report eight heterozygous de novo variants (one frameshift, two splice site, and five missense) in the gene encoding the BAF complex subunit double plant homeodomain finger 2 (DPF2)...
February 5, 2018: American Journal of Human Genetics
Ming Wang, Neil White, Volker Grimm, Helen Hofman, David Doley, Grant Thorp, Bronwen Cribb, Ella Wherritt, Liqi Han, John Wilkie, Jim Hanan
Background and Aims: Functional-structural plant (FSP) models have been widely used to understand the complex interactions between plant architecture and underlying developmental mechanisms. However, to obtain evidence that a model captures these mechanisms correctly, a clear distinction must be made between model outputs used for calibration and thus verification, and outputs used for validation. In pattern-oriented modelling (POM), multiple verification patterns are used as filters for rejecting unrealistic model structures and parameter combinations, while a second, independent set of patterns is used for validation...
February 7, 2018: Annals of Botany
N A Bryant, G S Wilkie, C A Russell, L Compston, D Grafham, L Clissold, K McLay, L Medcalf, R Newton, A J Davison, D M Elton
Equine herpesvirus 1 (EHV-1) causes respiratory disease, abortion, neonatal death and neurological disease in equines and is endemic in most countries. The viral factors that influence EHV-1 disease severity are poorly understood, and this has hampered vaccine development. However, the N752D substitution in the viral DNA polymerase catalytic subunit has been shown statistically to be associated with neurological disease. This has given rise to the term "neuropathic strain," even though strains lacking the polymorphism have been recovered from cases of neurological disease...
February 9, 2018: Transboundary and Emerging Diseases
Laura Bozal-Basterra, Itziar Martín-Ruíz, Lucia Pirone, Yinwen Liang, Jón Otti Sigurðsson, Maria Gonzalez-Santamarta, Immacolata Giordano, Estibaliz Gabicagogeascoa, Angela de Luca, Jose A Rodríguez, Andrew O M Wilkie, Jürgen Kohlhase, Deborah Eastwood, Christopher Yale, Jesper V Olsen, Michael Rauchman, Kathryn V Anderson, James D Sutherland, Rosa Barrio
Townes-Brocks syndrome (TBS) is characterized by a spectrum of malformations in the digits, ears, and kidneys. These anomalies overlap those seen in a growing number of ciliopathies, which are genetic syndromes linked to defects in the formation or function of the primary cilia. TBS is caused by mutations in the gene encoding the transcriptional repressor SALL1 and is associated with the presence of a truncated protein that localizes to the cytoplasm. Here, we provide evidence that SALL1 mutations might cause TBS by means beyond its transcriptional capacity...
February 1, 2018: American Journal of Human Genetics
Fang Kuan Chiou, Sue V Beath, Gwen M Wilkie, Mark A Vickers, Bruce Morland, Girish L Gupte
EBV-CTL immunotherapy targets EBV antigens expressed by tumor cells in PTLD. Data on outcome of EBV-CTL in pSOT patients are limited. The aim of the study is to describe our experience with allogeneic, third-party EBV-CTL for the treatment of PTLD in pSOT patients in a single tertiary center. Retrospective review was performed of all pSOT patients who received EBV-CTL for PTLD. PTLD was diagnosed using World Health Organization histologic criteria. EBV-CTLs were derived from human leukocyte antigen-typed, EBV-seropositive third-party donors, and cryopreserved and maintained by an accredited national blood transfusion service...
February 1, 2018: Pediatric Transplantation
Michele R Schaeffer, Christopher J Ryerson, Andrew H Ramsook, Yannick Molgat-Seon, Sabrina S Wilkie, Satvir S Dhillon, Reid A Mitchell, A William Sheel, Nasreen Khalil, Pat G Camp, Jordan A Guenette
Our understanding of the mechanisms of dyspnoea in fibrotic interstitial lung disease (ILD) is incomplete. The aims of this study were two-fold: 1) to determine whether dyspnoea intensity is better predicted by neural respiratory drive (NRD) or neuromechanical uncoupling (NMU) of the respiratory system in fibrotic ILD, and 2) to examine the effect of breathing 60% oxygen on NRD, NMU and dyspnoea ratings.Fourteen patients with fibrotic ILD were included. Visit 1 comprised a familiarisation incremental cycle exercise test, Visit 2 comprised a normoxic incremental cycling test to address Aim 1, and Visits 3 and 4 consisted of constant-load cycling while breathing room air or 60% oxygen to address Aim 2...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Martin Wilkie
No abstract text is available yet for this article.
January 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Emily J Goldstein, William T Harvey, Gavin S Wilkie, Samantha J Shepherd, Alasdair R MacLean, Pablo R Murcia, Rory N Gunson
Genetic surveillance of seasonal influenza is largely focused on sequencing of the haemagglutinin gene. Consequently, our understanding of the contribution of the remaining seven gene segments to the evolution and epidemiological dynamics of seasonal influenza is relatively limited. The increased availability of next-generation sequencing technologies allows rapid and economic whole-genome sequencing (WGS) of influenza virus. Here, 150 influenza A(H3N2) positive clinical specimens with linked epidemiological data, from the 2014/15 season in Scotland, were sequenced directly using both Sanger sequencing of the HA1 region and WGS using the Illumina MiSeq platform...
December 21, 2017: Microbial Genomics
Adrian R Wilkie, Mayuri Sharma, Jean M Pesola, Maria Ericsson, Rosio Fernandez, Donald M Coen
Herpesviruses replicate and package their genomes into capsids in replication compartments within the nuclear interior. Capsids then move to the inner nuclear membrane for envelopment and release into the cytoplasm in a process called nuclear egress. We previously found that nuclear F-actin is induced upon infection with the β-herpesvirus, human cytomegalovirus, and is important for nuclear egress and capsid localization away from replication compartment-like inclusions towards the nuclear rim. Despite these and related findings, it has not been shown that any specific motor protein is involved in herpesvirus nuclear egress...
January 3, 2018: Journal of Virology
Rowena Killick, Alberto Rodriguez Barbon, Michelle Barrows, Andrew Routh, Richard Saunders, Charlotte Day, P G Cert Exotic Animal Studies, Adam Naylor, Nicolette Hayward, David Sewell, Kieran Borgeat, Aimee L Drane, Lois Wilkie
Eleven cases of dilated cardiomyopathy have been diagnosed and treated in captive Livingstone fruit bats ( Pteropus livingstonii) in the United Kingdom over the past 7 yr. All but one case received treatment with a diuretic plus an angiotensin-converting enzyme inhibitor (ACEI), and, or pimobendan. One case is still under treatment with pimobendan alone, following diagnosis before onset of clinical signs. Diuretic treatment consisted of furosemide at a dose rate of 0.5-5 mg/kg, one to three times daily, and, or spironolactone at a dose rate of 1-4 mg/kg, once or twice daily...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
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