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https://www.readbyqxmd.com/read/28716998/extended-training-to-prepare-gps-for-future-workforce-needs-a-qualitative-investigation-of-a-1-year-fellowship-in-urgent-care
#1
Jeremy Dale, Rachel Russell, Frances Harkness, Veronica Wilkie, Matthew Aiello
BACKGROUND: It has been argued that UK general practice specialist training should be extended to better prepare GPs for the challenges facing 21st-century health care. Evidence is needed to inform how this should occur. AIM: To investigate the experience of recently trained GPs undertaking a 1-year full-time fellowship programme designed to provide advanced skills training in urgent care, integrated care, leadership, and academic practice; and its impact on subsequent career development...
July 17, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28697269/pediatric-cellulitis-a-red-hot-concern
#2
Andrew Shriner, Laurie Wilkie
Cellulitis and other skin and soft tissue infections are a common reason for children to seek care, both in the primary care setting and the emergency department. Cellulitis is a common skin and soft-tissue infection that is usually caused by streptococci bacteria or, less commonly, Staphylococcus aureus. Most children recover quickly from cellulitis, but a small subset will require hospitalization. Practitioners need to be skilled in the diagnosis and treatment of cellulitis, including recognition of the need for inpatient treatment...
July 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28697265/pediatric-hospital-medicine
#3
EDITORIAL
Laurie Wilkie
No abstract text is available yet for this article.
July 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28688313/laparoscopic-management-of-a-complicated-case-of-wilkie-s-syndrome-a-case-report
#4
Yehya Khodear, Wisam Al-Ramli, Zsolt Bodnar
INTRODUCTION: Superior mesenteric artery (SMA) syndrome also known as Wilkie's syndrome is a rare condition caused by the entrapment of the third part of the duodenum between the aorta and the SMA. The incidence of Wilkie's syndrome range between 0.013% and 0.3%. The normal angle between the aorta and SMA has been described to range between 38° and 65°, whereas in Wilkie's syndrome this angle is reduced to less than 20° causing gastric outlet obstruction. CASE PRESENTATION: We report a case of a previously diagnosed 43 year-old male with SMA syndrome, whom had been conservatively managed for 5-years for recurrent admissions with symptoms of gastric outlet obstruction...
June 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28686291/gonadal-mosaicism-and-non-invasive-prenatal-diagnosis-for-reassurance-in-sporadic-paternal-age-effect-pae-disorders
#5
Andrew O M Wilkie, Anne Goriely
No abstract text is available yet for this article.
July 7, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28676504/overcoming-socioeconomic-differences-in-the-equitable-delivery-of-peritoneal-dialysis
#6
EDITORIAL
Martin Wilkie
No abstract text is available yet for this article.
July 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28673451/a-prospective-proteomics-study-identified-potential-biomarkers-of-encapsulating-peritoneal-sclerosis-in-peritoneal-effluent
#7
Vasileios Zavvos, Anthony T Buxton, Caroline Evans, Mark Lambie, Simon J Davies, Nicholas Topley, Martin Wilkie, Angela Summers, Paul Brenchley, Dimitrios S Goumenos, Timothy S Johnson
Encapsulating peritoneal sclerosis (EPS) is a potentially devastating complication of peritoneal dialysis (PD). Diagnosis is often delayed due to the lack of effective and accurate diagnostic tools. We therefore examined peritoneal effluent for potential biomarkers that could predict or confirm the diagnosis of EPS and would be valuable in stratifying at-risk patients and driving appropriate interventions. Using prospectively collected samples from the Global Fluid Study and a cohort of Greek PD patients, we utilized 2D SDSPAGE/ MS and iTRAQ to identify changes in the peritoneal effluent proteome from patients diagnosed with EPS and controls matched for treatment exposure...
July 1, 2017: Kidney International
https://www.readbyqxmd.com/read/28667194/the-role-of-environmental-factors-for-the-onset-of-restricted-mobility-outside-the-home-among-older-adults-with-osteoarthritis-a-prospective-cohort-study
#8
Merja Rantakokko, Ross Wilkie
OBJECTIVES: The study examines how environmental factors contribute to the onset of restricted mobility outside the home among older adults with osteoarthritis. METHODS: This is a prospective cohort study of adults aged 50 years and older with osteoarthritis (n=1802). Logistic regression tested the association between the onset of restricted mobility outside the home and health, sociodemographic and perceived environmental barriers (hills and steep slopes, inaccessible public buildings, poor pavement condition, lack of access to public parks or sport facilities, heavy traffic or speeding cars and poor weather)...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28662873/asymptomatic-hypertrophic-cardiomyopathy-diagnosis-and-therapy
#9
REVIEW
Virginia Luis Fuentes, Lois J Wilkie
Hypertrophic cardiomyopathy (HCM) affects 15% of cats, and prevalence increases with age. Although many cats with HCM will have normal life expectancy, some cats die suddenly or will develop congestive heart failure or arterial thromboembolism (ATE). High-risk cats can be recognized by left atrial enlargement on echocardiography, which can be missed on physical examination as a heart murmur is often absent. Alternatively, plasma biomarkers can be measured as an initial screening test; echocardiography is indicated in cats with plasma NT-probrain natriuretic peptide concentrations exceeding 100 pmol/L...
June 27, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28660836/superior-mesenteric-artery-syndrome-a-single-centre-experience-of-laparoscopic-duodenojejunostomy-as-the-operation-of-choice
#10
G C Kirby, E R Faulconer, S J Robinson, A Perry, R Downing
INTRODUCTION The superior mesenteric artery (SMA) syndrome, or Wilkie's syndrome, is a rare cause of postprandial epigastric pain, vomiting and weight loss caused by compression of the third part of the duodenum as it passes beneath the proximal superior mesenteric artery. The syndrome may be precipitated by sudden weight loss secondary to other pathologies, such as trauma, malignancy or eating disorders. Diagnosis is confirmed by angiography, which reveals a reduced aorto-SMA angle and distance, and contrast studies showing duodenal obstruction...
July 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28651119/experimental-ultrasonic-characterization-of-polyester-based-materials-for-cultural-heritage-applications
#11
Andres Arciniegas, Loic Martinez, Arnaud Briand, Sophie Prieto, Stéphane Serfaty, Nicolas Wilkie-Chancellier
For several years, the Réunion des musées nationaux - Grand-Palais has produced polyester resin reproductions in order to replace marble sculptures that have weakened by outdoor exposure. These objects are made of a complex multilayered polyester composite material including reinforcements to ensure the mechanical strength of the final structure and mineral fillers that allow to imitate the original aesthetics. However, the final structure also weakens because of constant outdoor exposure and ageing. This observation leads today to conduct research related to the structural health monitoring of reproductions for preventive conservation of cultural heritage...
June 17, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28650516/asymmetric-synthesis-of-pyrrolidine-containing-chemical-scaffolds-via-tsuji-trost-allylation-of-n-tert-butanesulfinyl-imines
#12
Rafid Dawood, Irene Georgiou, Ross Wilkie, William Lewis, Robert Andrew Stockman
A simple and efficient asymmetric synthesis of novel sp3-rich pyrrolidine chemical scaffolds over five steps starting from simple ketones is described. Key steps involve the use of tert-butanesulfinamide as a chiral auxiliary to perform an asymmetric Tsuji-Trost allylation, with subsequent cross-metathesis with an acrylate ester and reduction of the sulfinimine/cyclisation of the resulting amine giving the pyrrolidine scaffolds in high yields and diastereoselectivites. By removing the chiral auxiliary and functionalising the ester group, the resulting scaffold core can be further derivatised...
June 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28635532/assessing-physical-symptoms-during-the-postpartum-period-reliability-and-validity-of-the-primary-health-questionnaire-somatic-symptom-subscale-phq-15
#13
Stephanie Wilkie, Ros Crawley, Susan Button, Alexandra Thornton, Susan Ayers
INTRODUCTION: This study aimed at establishing the reliability and validity of the primary health questionnaire (PHQ-15) somatic symptom severity subscale for postpartum women. METHODS: Women (N = 495) completed the PHQ-15 approximately 6 weeks postpartum during the baseline phase of a randomized controlled trial evaluating a writing intervention for postnatal health in England. Reliability was assessed using internal consistency statistics and convergent validity by comparing differences in self-reported physical health, health-related quality of life (QoL) and primary care usage by PHQ-15 symptom severity category...
February 20, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28628105/identification-of-liver-specific-enhancer-promoter-activity-in-the-3-untranslated-region-of-the-wild-type-aav2-genome
#14
Grant J Logan, Allison P Dane, Claus V Hallwirth, Christine M Smyth, Emilie E Wilkie, Anais K Amaya, Erhua Zhu, Neeta Khandekar, Samantha L Ginn, Sophia H Y Liao, Sharon C Cunningham, Natsuki Sasaki, Martí Cabanes-Creus, Patrick P L Tam, David W Russell, Leszek Lisowski, Ian E Alexander
Vectors based on adeno-associated virus type 2 (AAV2) are powerful tools for gene transfer and genome editing applications. The level of interest in this system has recently surged in response to reports of therapeutic efficacy in human clinical trials, most notably for those in patients with hemophilia B (ref. 3). Understandably, a recent report drawing an association between AAV2 integration events and human hepatocellular carcinoma (HCC) has generated controversy about the causal or incidental nature of this association and the implications for AAV vector safety...
June 19, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28600189/effect-of-high-dose-simvastatin-on-cognitive-neuropsychiatric-and-health-related-quality-of-life-measures-in-secondary-progressive-multiple-sclerosis-secondary-analyses-from-the-ms-stat-randomised-placebo-controlled-trial
#15
Dennis Chan, Sophie Binks, Jennifer M Nicholas, Chris Frost, M Jorge Cardoso, Sebastien Ourselin, David Wilkie, Richard Nicholas, Jeremy Chataway
BACKGROUND: In the 24-month MS-STAT phase 2 trial, we showed that high-dose simvastatin significantly reduced the annualised rate of whole brain atrophy in patients with secondary progressive multiple sclerosis (SPMS). We now describe the results of the MS-STAT cognitive substudy, in which we investigated the treatment effect on cognitive, neuropsychiatric, and health-related quality-of-life (HRQoL) outcome measures. METHODS: We did a secondary analysis of MS-STAT, a 24-month, double-blind, controlled trial of patients with SPMS done at three neuroscience centres in the UK between Jan 28, 2008, and Nov 4, 2011...
August 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28597000/intraoperative-ultrasound-as-a-screening-modality-for-the-detection-of-liver-metastases-during-resection-of-primary-colorectal-cancer-a-systematic-review
#16
REVIEW
Signe Bremholm Ellebæk, Claus Wilki Fristrup, Michael Bau Mortensen
Colorectal cancer (CRC) is one of the most common cancer diseases worldwide. One in 4 patients with CRC will have a disseminated disease at the time of diagnosis and often in the form of synchronous liver metastases. Studies suggest that up to 30% of patients have non-recognized hepatic metastases during primary surgery for CRC. Intraoperative ultrasonography examination (IOUS) of the liver to detect liver metastases was considered the gold standard during open CRC surgery. Today laparoscopic surgery is the standard procedure, but laparoscopic ultrasound examination (LUS) is not performed routinely...
April 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/28589671/pain-and-mortality-in-older-adults-the-influence-of-pain-phenotype
#17
Diane Smith, Ross Wilkie, Peter Croft, John McBeth
Objective Moderate to severe chronic pain affects one in five adults. Pain may increase the risk of mortality but the relationship is unclear. This study investigated whether mortality risk was influenced by pain phenotype, characterised by pain extent or pain impact on daily life. Methods The study population was drawn from two large population cohorts of adults aged ≥50 years; the English Longitudinal Study of Ageing (ELSA) (n=6324) and the North Staffordshire Osteoarthritis Project (NorStOP) (n=10985)...
June 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28587838/effects-of-water-ph-on-the-uptake-and-elimination-of-the-piscicide-3-trifluoromethyl-4-nitrophenol-tfm-by-larval-sea-lamprey
#18
Benjamin L Hlina, Laura R Tessier, Michael P Wilkie
Invasive sea lamprey (Petromyzon marinus) populations in the Great Lakes are controlled by applying the piscicide, 3-trifluoromethyl-4-nitrophenol (TFM), to infested streams with larval sea lamprey (ammocoetes). While treatment mortality is >90%, surviving lamprey, called residuals, can undermine control efforts. A key determinant of TFM effectiveness is water pH, which can fluctuate daily and seasonally in surface waters. The objectives of this research were to evaluate the influence of pH on the uptake, elimination, and accumulation of TFM by larval sea lamprey using radio-labeled TFM ((14)C-TFM), when exposed to a nominal concentration of 4...
June 3, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28585066/modeling-the-dichotomy-of-the-immune-response-to-cancer-cytotoxic-effects-and-tumor-promoting-inflammation
#19
Kathleen P Wilkie, Philip Hahnfeldt
Although the immune response is often regarded as acting to suppress tumor growth, it is now clear that it can be both stimulatory and inhibitory. The interplay between these competing influences has complex implications for tumor development, cancer dormancy, and immunotherapies. In fact, early immunotherapy failures were partly due to a lack in understanding of the nonlinear growth dynamics these competing immune actions may cause. To study this biological phenomenon theoretically, we construct a minimally parameterized framework that incorporates all aspects of the immune response...
June 5, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28561654/the-current-landscape-of-early-drug-development-for-patients-with-sarcoma
#20
Breelyn A Wilky, Robin L Jones, Vicki L Keedy
Until recently, advancements in the treatment of patients with adult soft tissue sarcomas have been relatively slow. This is, in part, due to their heterogeneity and rarity. A better understanding of the biology and differences among the various histologies has led to substantial growth in novel strategies. In addition to novel cytotoxic chemotherapies, agents targeting platelet-derived growth factor receptor-α (PDGFRα), mTOR, and angiogenesis are areas of active investigation. Additionally, with the success of checkpoint inhibitors in other malignancies and early encouraging results of checkpoint inhibitors in some sarcoma subtypes, this approach is being widely investigated in various sarcomas...
2017: American Society of Clinical Oncology Educational Book
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