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https://www.readbyqxmd.com/read/27903847/technique-failure-talking-a-common-language
#1
EDITORIAL
Martin Wilkie, Simon Davies
No abstract text is available yet for this article.
November 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27884935/diagnostic-value-of-exome-and-whole-genome-sequencing-in-craniosynostosis
#2
Kerry A Miller, Stephen R F Twigg, Simon J McGowan, Julie M Phipps, Aimée L Fenwick, David Johnson, Steven A Wall, Peter Noons, Katie E M Rees, Elizabeth A Tidey, Judith Craft, John Taylor, Jenny C Taylor, Jacqueline A C Goos, Sigrid M A Swagemakers, Irene M J Mathijssen, Peter J van der Spek, Helen Lord, Tracy Lester, Noina Abid, Deirdre Cilliers, Jane A Hurst, Jenny E V Morton, Elizabeth Sweeney, Astrid Weber, Louise C Wilson, Andrew O M Wilkie
BACKGROUND: Craniosynostosis, the premature fusion of one or more cranial sutures, occurs in ∼1 in 2250 births, either in isolation or as part of a syndrome. Mutations in at least 57 genes have been associated with craniosynostosis, but only a minority of these are included in routine laboratory genetic testing. METHODS: We used exome or whole genome sequencing to seek a genetic cause in a cohort of 40 subjects with craniosynostosis, selected by clinical or molecular geneticists as being high-priority cases, and in whom prior clinically driven genetic testing had been negative...
November 24, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27883292/il1a-rs1800587-associates-with-chronic-noncrisis-pain-in-sickle-cell-disease
#3
Xiaoyu Hu, Ellie H Jhun, Yingwei Yao, Ying He, Robert E Molokie, Diana J Wilkie, Zaijie J Wang
AIM: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a cis-transcriptional regulatory region. METHODS: We genotyped IL1A rs1800587 and performed association studies with phenotype data obtained by a multidimensional pain assessment tool using the PAINReportIt(®) Questionnaire...
November 24, 2016: Pharmacogenomics
https://www.readbyqxmd.com/read/27865363/pathology-based-staging-for-hpv-positive-squamous-carcinoma-of-the-oropharynx
#4
B H Haughey, P Sinha, D Kallogjeri, R L Goldberg, J S Lewis, J F Piccirillo, R S Jackson, E J Moore, M Brandwein-Gensler, S J Magnuson, W R Carroll, T M Jones, M D Wilkie, A Lau, N S Upile, Jon Sheard, J Lancaster, S Tandon, M Robinson, D Husband, I Ganly, J P Shah, D M Brizel, B O'Sullivan, J A Ridge, W M Lydiatt
OBJECTIVE: The rapid worldwide rise in incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has generated studies confirming this disease as an entity distinct from traditional OPSCC. Based on pathology, surgical studies have revealed prognosticators specific to HPV-positive OPSCC. The current AJCC/UICC staging and pathologic nodal (pN)-classification do not differentiate for survival, demonstrating the need for new, HPV-specific OPSCC staging...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27856798/the-synthetic-diazonamide-dz-2384-has-distinct-effects-on-microtubule-curvature-and-dynamics-without-neurotoxicity
#5
Michal Wieczorek, Joseph Tcherkezian, Cynthia Bernier, Andrea E Prota, Sami Chaaban, Yannève Rolland, Claude Godbout, Mark A Hancock, Joseph C Arezzo, Ozhan Ocal, Cecilia Rocha, Natacha Olieric, Anita Hall, Hui Ding, Alexandre Bramoullé, Matthew G Annis, George Zogopoulos, Patrick G Harran, Thomas M Wilkie, Rolf A Brekken, Peter M Siegel, Michel O Steinmetz, Gordon C Shore, Gary J Brouhard, Anne Roulston
Microtubule-targeting agents (MTAs) are widely used anticancer agents, but toxicities such as neuropathy limit their clinical use. MTAs bind to and alter the stability of microtubules, causing cell death in mitosis. We describe DZ-2384, a preclinical compound that exhibits potent antitumor activity in models of multiple cancer types. It has an unusually high safety margin and lacks neurotoxicity in rats at effective plasma concentrations. DZ-2384 binds the vinca domain of tubulin in a distinct way, imparting structurally and functionally different effects on microtubule dynamics compared to other vinca-binding compounds...
November 16, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27848746/results-from-england-s-2016-report-card-on-physical-activity-for-children-and-youth
#6
Hannah Wilkie, Martyn Standage, Lauren Sherar, Sean Cumming, Caley Parnell, Adrian Davis, Charlie Foster, Russ Jago
BACKGROUND: Regular physical activity improves physical and mental health, yet children's physical activity levels were low in England's 2014 Report Card. Within this paper, we update the 2014 Report Card to assess current information for the 9 indicators of physical activity. METHODS: A search for nationally representative data on 9 indicators of physical activity was conducted and the data were assessed by an expert panel. The panel assigned grades [ie, A, B, C, D, F, or INC (incomplete)] to each indicator based on whether children across England were achieving specific benchmarks...
November 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27831695/intraindividual-variability-and-falls-in-older-adults
#7
Sarah Bauermeister, Graham Sutton, Mark Mon-Williams, Richard Wilkie, Jack Graveson, Alison Cracknell, Charles Wilkinson, Raymond Holt, David Bunce
Objective: We investigated whether a simple measure of reaction time (RT) intraindividual variability (IIV) was associated with falls in older adults. Falls and fall-related injuries represent a major cost to health care systems, it is therefore critically important to find measures that can readily identify older adults at greater risk of falling. Method: Cognitive and motor function were investigated in 108 adults aged 53 to 93 years (M = 73.49) recruited across the local community and hospital outpatient department...
November 10, 2016: Neuropsychology
https://www.readbyqxmd.com/read/27789485/patient-participation-groups-in-general-practice-building-better-partnerships
#8
EDITORIAL
Patricia Wilkie
No abstract text is available yet for this article.
November 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27784686/relationship-between-oxidative-stress-and-brain-swelling-in-goldfish-carassius-auratus-exposed-to-high-environmental-ammonia
#9
David F J Lisser, Zachary M Lister, Phillip Q H Pham-Ho, Graham R Scott, Michael P Wilkie
Build-ups of ammonia can cause potentially fatal brain swelling in mammals, but such swelling is reversible in the anoxia- and ammonia-tolerant goldfish (Carassius auratus). We investigated brain swelling and its possible relationship to oxidative stress in the brain and liver of goldfish acutely exposed to high external ammonia (HEA; 5 mmol L(-1) NH4Cl) at two different acclimation temperatures (14°C, 4°C). At 14ºC, HEA for 72 h increased internal ammonia and glutamine concentrations caused cellular oxidative damage in brain and liver...
October 26, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27756852/framework-for-mining-and-analysis-of-standardized-nursing-care-plan-data
#10
Ashfaq Khokhar, Muhammad Kamran Lodhi, Yingwei Yao, Rashid Ansari, Gail Keenan, Diana J Wilkie
Despite an unprecedented amount of health-related data being amassed from various technological innovations, our ability to process this data and extract hidden knowledge has yet to catch up with this explosive growth. Although nursing care plans can be an effective tool to support the achievement of desired patient outcomes, their online collection, storage, and processing is lagging far behind. As a result, the impact of nursing care is not well understood from qualitative as well as quantitative perspectives...
October 18, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27706161/full-genome-sequence-and-sfrna-interferon-antagonist-activity-of-zika-virus-from-recife-brazil
#11
Claire L Donald, Benjamin Brennan, Stephanie L Cumberworth, Veronica V Rezelj, Jordan J Clark, Marli T Cordeiro, Rafael Freitas de Oliveira França, Lindomar J Pena, Gavin S Wilkie, Ana Da Silva Filipe, Christopher Davis, Joseph Hughes, Margus Varjak, Martin Selinger, Luíza Zuvanov, Ania M Owsianka, Arvind H Patel, John McLauchlan, Brett D Lindenbach, Gamou Fall, Amadou A Sall, Roman Biek, Jan Rehwinkel, Esther Schnettler, Alain Kohl
BACKGROUND: The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern. Little is currently known about the evolution and biology of ZIKV and the factors that contribute to the associated pathogenesis. Determining genomic sequences of clinical viral isolates and characterization of elements within these are an important prerequisite to advance our understanding of viral replicative processes and virus-host interactions...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27699189/dataset-of-twist1-regulated-genes-in-the-cranial-mesoderm-and-a-transcriptome-comparison-of-cranial-mesoderm-and-cranial-neural-crest
#12
Heidi Bildsoe, Xiaochen Fan, Emilie E Wilkie, Ator Ashoti, Vanessa J Jones, Melinda Power, Jing Qin, Junwen Wang, Patrick P L Tam, David A F Loebel
This article contains data related to the research article entitled "Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance" by Bildsoe et al. (2016) [1]. The data presented here are derived from: (1) a microarray-based comparison of sorted cranial mesoderm (CM) and cranial neural crest (CNC) cells from E9.5 mouse embryos; (2) comparisons of transcription profiles of head tissues from mouse embryos with a CM-specific loss-of-function of Twist1 and control mouse embryos collected at E8...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27659924/the-2016-ispd-update-on-prevention-and-treatment-of-peritonitis-grading-the-evidence
#13
EDITORIAL
Martin Wilkie
No abstract text is available yet for this article.
September 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27633438/a-systematic-examination-of-preoperative-surgery-warm-up-routines
#14
T W Pike, S Pathak, F Mushtaq, R M Wilkie, M Mon-Williams, J P A Lodge
BACKGROUND: Recent evidence indicates that a preoperative warm-up is a potentially useful tool in facilitating performance. But what factors drive such improvements and how should a warm-up be implemented? METHODS: In order to address these issues, we adopted a two-pronged approach: (1) we conducted a systematic review of the literature to identify existing studies utilising preoperative simulation techniques; (2) we performed task analysis to identify the constituent parts of effective warm-ups...
September 15, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27624739/heat-shock-protein-70-expression-in-the-equine-cornea
#15
Cornelia Peterson, Elizabeth Driskell, David Wilkie, Christopher Premanandan, Ralph Hamor
OBJECTIVE: Expression of the 70-kDa heat-shock protein (HSP70) has been demonstrated in normal canine corneal epithelium, and inducible expression has been suggested to facilitate wound resolution through organized migration, proliferation, and adhesion of the corneal epithelial cells. Diminished expression of HSP70 may therefore contribute to prolonged healing in the pathologic cornea of other companion animal species, including the horse. ANIMAL STUDIED: Normal and pathologic equine cornea was evaluated to determine whether the expression of HSP70 is correlated with appropriate corneal epithelial wound healing...
September 13, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27621272/implementing-the-painrelieveit-randomized-controlled-trial-in-hospice-care-mechanisms-for-success-and-meeting-pcori-methodology-standards
#16
Miriam O Ezenwa, Marie L Suarez, Jesus D Carrasco, Theresa Hipp, Anayza Gill, Jacob Miller, Robert Shea, David Shuey, Zhongsheng Zhao, Veronica Angulo, Timothy McCurry, Joanna Martin, Yingwei Yao, Robert E Molokie, Zaijie Jim Wang, Diana J Wilkie
This purpose of this article is to describe how we adhere to the Patient-Centered Outcomes Research Institute's (PCORI) methodology standards relevant to the design and implementation of our PCORI-funded study, the PAINRelieveIt Trial. We present details of the PAINRelieveIt Trial organized by the PCORI methodology standards and components that are relevant to our study. The PAINRelieveIt Trial adheres to four PCORI standards and 21 subsumed components. The four standards include standards for formulating research questions, standards associated with patient centeredness, standards for data integrity and rigorous analyses, and standards for preventing and handling missing data...
September 12, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27600164/nurses-beliefs-regarding-pain-in-critically-ill-children-a-mixed-methods-study
#17
Cynthia M LaFond, Catherine Van Hulle Vincent, Kimberly Oosterhouse, Diana J Wilkie
: The purpose of this study was to provide a current and comprehensive evaluation of nurses' beliefs regarding pain in critically ill children. DESIGN AND METHODS: A convergent parallel mixed-methods design was used. Nurse beliefs were captured via questionnaire and interview and then compared. RESULTS: Forty nurses participated. Most beliefs reported via questionnaire were consistent with effective pain management practices. Common inaccurate beliefs included the need to verify pain reports with physical indicators and the pharmacokinetics of intravenous opioids...
November 2016: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/27577723/trust-building-recruitment-strategies-for-researchers-conducting-studies-in-african-american-aa-churches-lessons-learned
#18
Gloria Bonner, Sharon Williams, Diana Wilkie, Alysha Hart, Glenda Burnett, Geraldine Peacock
BACKGROUND: An initial and vital important step in recruiting participants for church-based hospice and palliative care research is the establishment of trust and credibility within the church community. Mistrust of medical research is an extremely important barrier hindering recruitment in African American (AA) communities. A church-based EOL dementia education project is currently being conducted at four large urban AA churches. Church leaders voiced mistrust concerns of previous researchers who conducted investigations in their faith-based institutions...
August 30, 2016: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/27555312/a-role-for-nuclear-f-actin-induction-in-human-cytomegalovirus-nuclear-egress
#19
Adrian R Wilkie, Jessica L Lawler, Donald M Coen
UNLABELLED: Herpesviruses, which include important pathogens, remodel the host cell nucleus to facilitate infection. This remodeling includes the formation of structures called replication compartments (RCs) in which herpesviruses replicate their DNA. During infection with the betaherpesvirus, human cytomegalovirus (HCMV), viral DNA synthesis occurs at the periphery of RCs within the nuclear interior, after which assembled capsids must reach the inner nuclear membrane (INM) for translocation to the cytoplasm (nuclear egress)...
2016: MBio
https://www.readbyqxmd.com/read/27548045/characterizing-the-pain-score-trajectories-of-hospitalized-adult-medical-and-surgical-patients-a-retrospective-cohort-study
#20
Thomas Kannampallil, William L Galanter, Suzanne Falck, Michael J Gaunt, Robert D Gibbons, Robert McNutt, Richard Odwazny, Gordon Schiff, Allen J Vaida, Diana J Wilkie, Bruce L Lambert
Pain care for hospitalized patients is often suboptimal. Representing pain scores as a graphical trajectory may provide insights into the understanding and treatment of pain. We describe a 1-year, retrospective, observational study to characterize pain trajectories of hospitalized adults during the first 48 hours after admission at an urban academic medical center. Using a subgroup of patients who presented with significant pain (pain score>4; n=7,762 encounters) we characterized pain trajectories and measured area under the curve, slope of the trajectory for the first two hours after admission, and pain intensity at plateau...
August 19, 2016: Pain
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