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https://www.readbyqxmd.com/read/28931692/strengthening-the-reporting-of-cohort-studies-in-peritoneal-dialysis
#1
EDITORIAL
Martin Wilkie
No abstract text is available yet for this article.
September 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28930732/uk-renal-registry-19th-annual-report-chapter-13-home-therapies-in-2015-national-and-centre-specific-analyses
#2
Matthew Tabinor, Anna Casula, Martin Wilkie, Simon Davies, Fergus Caskey, Mark Lambie
No abstract text is available yet for this article.
2017: Nephron
https://www.readbyqxmd.com/read/28930731/uk-renal-registry-19th-annual-report-chapter-12-multisite-dialysis-access-audit-in-england-northern-ireland-and-wales-in-2015-and-2014-pd-one-year-follow-up-national-and-centre-specific-analyses
#3
Barnaby Hole, Fergus Caskey, Katharine Evans, Richard Fluck, Mick Kumwenda, Retha Steenkamp, Martin Wilkie
No abstract text is available yet for this article.
2017: Nephron
https://www.readbyqxmd.com/read/28926204/acceptability-of-clinical-decision-support-interface-prototypes-for-a-nursing-electronic-health-record-to-facilitate-supportive-care-outcomes
#4
Janet Stifter, Vanessa E C Sousa, Alessandro Febretti, Karen Dunn Lopez, Andrew Johnson, Yingwei Yao, Gail M Keenan, Diana J Wilkie
PURPOSE: To determine the acceptability, usefulness, and ease of use for four nursing clinical decision support interface prototypes. METHODS: In a simulated hospital environment, 60 registered nurses (48 female; mean age = 33.7 ± 10.8; mean years of experience = 8.1 ± 9.7) participated in a randomized study with four study groups. Measures included acceptability, usefulness, and ease of use scales. FINDINGS: Mean scores were high for acceptability, usefulness, and the ease of use for all four groups...
September 19, 2017: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/28914635/clinical-genetics-of-craniosynostosis
#5
Andrew O M Wilkie, David Johnson, Steven A Wall
PURPOSE OF REVIEW: When providing accurate clinical diagnosis and genetic counseling in craniosynostosis, the challenge is heightened by knowledge that etiology in any individual case may be entirely genetic, entirely environmental, or anything in between. This review will scope out how recent genetic discoveries from next-generation sequencing have impacted on the clinical genetic evaluation of craniosynostosis. RECENT FINDINGS: Survey of a 13-year birth cohort of patients treated at a single craniofacial unit demonstrates that a genetic cause of craniosynostosis can be identified in one quarter of cases...
September 14, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28905882/identification-of-causative-variants-in-txnl4a-in-burn-mckeown-syndrome-and-isolated-choanal-atresia
#6
Jacqueline A C Goos, Sigrid M A Swagemakers, Stephen R F Twigg, Marieke F van Dooren, A Jeannette M Hoogeboom, Christian Beetz, Sven Günther, Frank J Magielsen, Charlotte W Ockeloen, Maria A Ramos-Arroyo, Rolph Pfundt, Helger G Yntema, Peter J van der Spek, Philip Stanier, Dagmar Wieczorek, Andrew O M Wilkie, Ans M W van den Ouweland, Irene M J Mathijssen, Jane A Hurst
Burn-McKeown syndrome (BMKS) is a rare syndrome characterized by choanal atresia, prominent ears, abnormalities of the outer third of the lower eyelid, structural cardiac abnormalities, conductive and sensorineural hearing loss, and cleft lip. Recently, causative compound heterozygous variants were identified in TXNL4A. We analyzed an individual with clinical features of BMKS and her parents by whole-genome sequencing and identified compound heterozygous variants in TXNL4A (a novel splice site variant (c.258-2A>G, (p...
October 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28903491/use-of-rat-primary-mesenteric-cells-for-the-prediction-of-pde4-inhibitor-drug-induced-vascular-injury
#7
Mark M Gosink, Robert E Chapin, Dean Wilkie, Scott Davenport, Steven W Kumpf, Bradley E Enerson, Christopher Houle, Petra Koza-Taylor, Todd A Wisialowski, Michael P Lawton
Drug-induced vascular injury (DIVI) in preclinical studies can delay, if not terminate, a drug development program. Clinical detection of DIVI can be very difficult as there are no definitive biomarkers known to reliably detect this disorder in all instances. The preclinical identification of DIVI requires detailed microscopic examination of a wide range of tissues although one of the most commonly affected areas in rats is the mesenteric vasculature. The reason for this predisposition of mesenteric arteries in rats as well as the exact mechanism and cell types involved in the initial development of these lesions have not been fully elucidated...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28901920/regulatory-models-and-model-behaviours
#8
Kathy Wilkie, John Tzountzouris
We appreciate the thoughtful and thought-provoking commentaries to our lead paper (Wilkie and Tzountzouris 2017) in this issue. Clearly, the question of how to best enable the behaviours of healthcare professionals to optimize their impact on our healthcare system is a complex one. We approach the question from the position of a health regulatory authority with a recognition that we cannot act alone. In our response to the valuable contributions to this issue of Healthcare Papers, we seek to educe the common themes that are presented...
2017: HealthcarePapers
https://www.readbyqxmd.com/read/28901918/enhancing-the-relationship-between-regulators-and-their-profession
#9
Zubin Austin
Regulators face unique pressures to balance competing priorities related to patient safety, public accountability, and practitioners' expectations. Historically, the collegial model of self-regulation has been used as a tool for risk management, to recognize the importance of profession- and context-specific judgment in complex, ambiguous clinical situations. Increasingly, as public accountability concerns have grown dominant within regulatory bodies, this collegial model has shifted toward a more antagonistic relationship between the regulators and the regulated...
2017: HealthcarePapers
https://www.readbyqxmd.com/read/28901917/ensuring-proactive-regulatory-initiatives-align-with-the-public-interest
#10
Kathleen Leslie, Sioban Nelson
Regulation of health professions in Ontario has been under scrutiny in recent years with critical media attention and multiple legislative reform measures. The College of Medical Laboratory Technologists of Ontario's proactive regulatory initiative on steering professional culture, described by Wilkie and Tzountzouris (2017) in their discussion paper, is an example of a regulator evolving its role in the face of changing healthcare demands. In this response, we emphasize how regulators considering these types of initiatives need to ensure the focus remains on transparently carrying out their legislative duty of serving and protecting the public interest...
2017: HealthcarePapers
https://www.readbyqxmd.com/read/28901913/professional-healthcare-regulation-and-practice-the-case-of-medicine-in-britain
#11
Mike Saks
This contribution comments selectively on the themes of the lead paper by Wilkie and Tzountzouris (2017) on aspects of Canadian healthcare regulation that impact on the crucial agenda of public protection. In a more skeptical sociopolitical climate in the modern world, these authors particularly highlight the need to ensure professional attitudes and behaviours enhance and sustain safe patient care - using the recent stance on professionalism of the College of Medical Laboratory Technologists of Ontario as an illustration of good practice...
2017: HealthcarePapers
https://www.readbyqxmd.com/read/28901912/enabling-evolving-practice-for-healthcare-professionals-a-regulator-s-journey
#12
Kathy Wilkie, John Tzountzouris
The inherent risk involved in the provision of healthcare services leads to the inevitable requirement of health human resource oversight to protect the public from harm (Bayne 2012). As healthcare systems evolve, so do theoretical models for, and practical applications of, health human resource oversight policy and processes. The College of Medical Laboratory Technologists of Ontario (CMLTO), as one of 26 health regulatory bodies in Ontario, implements programs or processes to enact and support changes in the knowledge, skill and judgment of their members...
2017: HealthcarePapers
https://www.readbyqxmd.com/read/28901911/defining-health-profession-regulators-roles-in-the-canadian-healthcare-system
#13
Joshua Tepper, Humayun Ahmed, Adalsteinn D Brown
Health professions regulation today faces a myriad of challenges, due to both the perceived performance of regulatory colleges, how health systems have evolved, and even larger political and economic shifts such as the renegotiation of NAFTA. In this issue of Healthcare Papers, Wilkie and Tzountzouris (2017) describe the work of the College of Medical Laboratory Technologists of Ontario (CMLTO) to redefine professionalism in the context of these challenges. Their paper, and the comments of the responding authors in this issue highlight that there, is an overarching perception that health regulatory structures - across a range of professions - are not working as effectively as they should...
2017: HealthcarePapers
https://www.readbyqxmd.com/read/28890403/sex-differences-in-respiratory-muscle-activation-patterns-during-high-intensity-exercise-in-healthy-humans
#14
Reid A Mitchell, Michele R Schaeffer, Andrew H Ramsook, Sabrina S Wilkie, Jordan A Guenette
Although women experience greater ventilatory constraints and have a higher work of breathing during exercise, they are less susceptible to diaphragm fatigue compared to men. The mechanisms for diaphragmatic fatigue resistance in women is unknown but may be related to sex differences in respiratory muscle recruitment. Accordingly, the purpose of this study was to determine if electromyography (EMG) of the diaphragm (EMGdi) and extra-diaphragmatic inspiratory muscles differ between sexes during exercise. Forty subjects (21M:19F) completed a constant load cycling test at 85% of maximum work rate until exhaustion, while instrumented with an oesophageal electrode catheter to measure EMGdi and surface electrodes to measure EMG of the sternocleidomastoid (EMGscm) and scalene (EMGsca) muscles...
September 7, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28886604/the-imperial-county-community-air-monitoring-network-a-model-for-community-based-environmental-monitoring-for-public-health-action
#15
Paul B English, Luis Olmedo, Ester Bejarano, Humberto Lugo, Eduardo Murillo, Edmund Seto, Michelle Wong, Galatea King, Alexa Wilkie, Dan Meltzer, Graeme Carvlin, Michael Jerrett, Amanda Northcross
The Imperial County Community Air Monitoring Network (the Network) is a collaborative group of community, academic, nongovernmental, and government partners designed to fill the need for more detailed data on particulate matter in an area that often exceeds air quality standards. The Network employs a community-based environmental monitoring process in which the community and researchers have specific, well-defined roles as part of an equitable partnership that also includes shared decision-making to determine study direction, plan research protocols, and conduct project activities...
July 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28865992/looking-forward-to-safer-hgvs-the-impact-of-mirrors-on-driver-reaction-times
#16
Callum David Mole, Richard McGilchrist Wilkie
Heavy Goods Vehicle (HGV) collisions are responsible for a disproportionate number of urban vulnerable road user casualties (VRU - cyclists and pedestrians). Blind-spots to the front and side of HGVs can make it difficult (sometimes impossible) to detect close proximity VRUs and may be the cause of some collisions. The current solution to this problem is to provide additional mirrors that can allow the driver to see into the blind-spots. However, keeping track of many mirrors requires frequent off-road glances which can be difficult to execute during demanding driving situations...
August 31, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28862425/btn3a1-discriminates-%C3%AE-%C3%AE-t-cell-phosphoantigens-from-nonantigenic-small-molecules-via-a-conformational-sensor-in-its-b30-2-domain
#17
Mahboob Salim, Timothy J Knowles, Alfie T Baker, Martin S Davey, Mark Jeeves, Pooja Sridhar, John Wilkie, Carrie R Willcox, Hachemi Kadri, Taher E Taher, Pierre Vantourout, Adrian Hayday, Youcef Mehellou, Fiyaz Mohammed, Benjamin E Willcox
Human Vγ9/Vδ2 T-cells detect tumor cells and microbial infections by recognizing small phosphorylated prenyl metabolites termed phosphoantigens (P-Ag). The type-1 transmembrane protein Butyrophilin 3A1 (BTN3A1) is critical to the P-Ag-mediated activation of Vγ9/Vδ2 T-cells; however, the molecular mechanisms involved in BTN3A1-mediated metabolite sensing are unclear, including how P-Ag's are discriminated from nonantigenic small molecules. Here, we utilized NMR and X-ray crystallography to probe P-Ag sensing by BTN3A1...
September 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28859775/n-o-248-directive-clinique-sur-l%C3%A2-%C3%A3-valuation-et-la-prise-en-charge-de-l%C3%A2-incontinence-urinaire-r%C3%A3-currente-%C3%A3-la-suite-d%C3%A2-une-chirurgie-visant-le-plancher-pelvien
#18
Danny Lovatsis, William Easton, David Wilkie
No abstract text is available yet for this article.
September 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28859774/no-248-guidelines-for-the-evaluation-and-treatment-of-recurrent-urinary-incontinence-following-pelvic-floor-surgery
#19
Danny Lovatsis, William Easton, David Wilkie
OBJECTIVE: To provide general gynaecologists and urogynaecologists with clinical guidelines for the management of recurrent urinary incontinence after pelvic floor surgery. OPTIONS: Evaluation includes history and physical examination, multichannel urodynamics, and possibly cystourethroscopy. Management includes conservative, pharmacological, and surgical interventions. OUTCOMES: These guidelines provide a comprehensive approach to the complicated issue of recurrent incontinence that is based on the underlying pathophysiological mechanisms...
September 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28858147/toward-meaningful-care-plan-clinical-decision-support-feasibility-and-effects-of-a-simulated-pilot-study
#20
Gail M Keenan, Karen Dunn Lopez, Yingwei Yao, Vanessa E C Sousa, Janet Stifter, Alessandro Febretti, Andrew Johnson, Diana J Wilkie
BACKGROUND: Clinical decision support (CDS) tools-with easily understood and actionable information, at the point of care-are needed to help registered nurses (RNs) make evidence-based decisions. Not clear are the optimal formats of CDS tools. Thorough, preclinical testing is desirable to avoid costly errors associated with premature implementation in electronic health records. OBJECTIVE: The aims of this study were to determine feasibility of the protocol designed to compare multiple CDS formats and evaluate effects of numeracy and graph literacy on RN adoption of best practices and care planning time in a simulated environment...
September 2017: Nursing Research
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