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https://www.readbyqxmd.com/read/29348183/neurophysiological-mechanisms-of-exertional-dyspnoea-in-fibrotic-interstitial-lung-disease
#1
Michele R Schaeffer, Christopher J Ryerson, Andrew H Ramsook, Yannick Molgat-Seon, Sabrina S Wilkie, Satvir S Dhillon, Reid A Mitchell, A William Sheel, Nasreen Khalil, Pat G Camp, Jordan A Guenette
Our understanding of the mechanisms of dyspnoea in fibrotic interstitial lung disease (ILD) is incomplete. The aims of this study were two-fold: 1) to determine whether dyspnoea intensity is better predicted by neural respiratory drive (NRD) or neuromechanical uncoupling (NMU) of the respiratory system in fibrotic ILD, and 2) to examine the effect of breathing 60% oxygen on NRD, NMU and dyspnoea ratings.Fourteen patients with fibrotic ILD were included. Visit 1 comprised a familiarisation incremental cycle exercise test, Visit 2 comprised a normoxic incremental cycling test to address Aim 1, and Visits 3 and 4 consisted of constant-load cycling while breathing room air or 60% oxygen to address Aim 2...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29311190/peritoneal-dialysis-pd-to-support-nonrenal-solid-organ-transplantation
#2
EDITORIAL
Martin Wilkie
No abstract text is available yet for this article.
January 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29310750/integrating-patient-and-whole-genome-sequencing-data-to-provide-insights-into-the-epidemiology-of-seasonal-influenza-a-h3n2-viruses
#3
Emily J Goldstein, William T Harvey, Gavin S Wilkie, Samantha J Shepherd, Alasdair R MacLean, Pablo R Murcia, Rory N Gunson
Genetic surveillance of seasonal influenza is largely focused on sequencing of the haemagglutinin gene. Consequently, our understanding of the contribution of the remaining seven gene segments to the evolution and epidemiological dynamics of seasonal influenza is relatively limited. The increased availability of next-generation sequencing technologies allows rapid and economic whole-genome sequencing (WGS) of influenza virus. Here, 150 influenza A(H3N2) positive clinical specimens with linked epidemiological data, from the 2014/15 season in Scotland, were sequenced directly using both Sanger sequencing of the HA1 region and WGS using the Illumina MiSeq platform...
December 21, 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29298889/a-role-for-myosin-va-in-human-cytomegalovirus-nuclear-egress
#4
Adrian R Wilkie, Mayuri Sharma, Jean M Pesola, Maria Ericsson, Rosio Fernandez, Donald M Coen
Herpesviruses replicate and package their genomes into capsids in replication compartments within the nuclear interior. Capsids then move to the inner nuclear membrane for envelopment and release into the cytoplasm in a process called nuclear egress. We previously found that nuclear F-actin is induced upon infection with the β-herpesvirus, human cytomegalovirus, and is important for nuclear egress and capsid localization away from replication compartment-like inclusions towards the nuclear rim. Despite these and related findings, it has not been shown that any specific motor protein is involved in herpesvirus nuclear egress...
January 3, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29297825/medical-management-of-dilated-cardiomyopathy-in-livingstone-fruit-bats-pteropus-livingstonii
#5
Rowena Killick, Alberto Rodriguez Barbon, Michelle Barrows, Andrew Routh, Richard Saunders, Charlotte Day, P G Cert Exotic Animal Studies, Adam Naylor, Nicolette Hayward, David Sewell, Kieran Borgeat, Aimee L Drane, Lois Wilkie
Eleven cases of dilated cardiomyopathy have been diagnosed and treated in captive Livingstone fruit bats ( Pteropus livingstonii) in the United Kingdom over the past 7 yr. All but one case received treatment with a diuretic plus an angiotensin-converting enzyme inhibitor (ACEI), and, or pimobendan. One case is still under treatment with pimobendan alone, following diagnosis before onset of clinical signs. Diuretic treatment consisted of furosemide at a dose rate of 0.5-5 mg/kg, one to three times daily, and, or spironolactone at a dose rate of 1-4 mg/kg, once or twice daily...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29289476/perspectives-on-research-participation-and-facilitation-among-dialysis-patients-clinic-personnel-and-medical-providers-a-focus-group-study
#6
Jennifer E Flythe, Julia H Narendra, Adeline Dorough, Jonathan Oberlander, Antoinette Ordish, Caroline Wilkie, Laura M Dember
BACKGROUND: Most prospective studies involving individuals receiving maintenance dialysis have been small, and many have had poor clinical translatability. Research relevance can be enhanced through stakeholder engagement. However, little is known about dialysis clinic stakeholders' perceptions of research participation and facilitation. The objective of this study was to characterize the perspectives of dialysis clinic stakeholders (patients, clinic personnel, and medical providers) on: (1) research participation by patients and (2) research facilitation by clinic personnel and medical providers...
December 19, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29274184/prevalence-of-mixed-genotype-hepatitis-c-virus-infections-in-the-uk-as-determined-by-genotype-specific-pcr-and-deep-sequencing
#7
A L McNaughton, V B Sreenu, G Wilkie, R Gunson, K Templeton, E C McWilliam Leitch
The incidence of mixed genotype hepatitis C virus infections in the UK is largely unknown. As the efficacy of direct acting antivirals is variable across different genotypes, treatment regimens are tailored to the infecting genotype, which may pose issues for the treatment of underlying genotypes within undiagnosed mixed genotype HCV infections. There is therefore a need to accurately diagnose mixed genotype infections prior to treatment. PCR-based diagnostic tools were developed to screen for the occurrence of mixed genotype infections caused by the most common UK genotypes, 1a and 3, in a cohort of 506 individuals diagnosed with either of these genotypes...
December 23, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29248457/malnutrition-in-pancreatic-ductal-adenocarcinoma-pda-dietary-pancreatic-enzymes-improve-short-term-health-but-stimulate-tumor-growth
#8
Yalda Zolghadri, Shreoshi Pal Choudhuri, Ozhan Ocal, Somayeh Layeghi- Ghalehsoukhteh, Feaven Berhe, Michael A Hale, Thomas M Wilkie
Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer that resists efforts to identify better chemotherapeutics. PDA is associated with chronic pancreatitis and acinar cell dedifferentiation. This reduces enzyme production by the exocrine pancreas, resulting in digestive insufficiencies. Malabsorption of partially digested food can cause bloating, overfilled intestines, abdominal pain, excessive feces, steatorrhea, and malnutrition. These maladies affect quality of life and restrict treatment options for pancreatitis and PDA...
December 14, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29243322/transient-myocardial-thickening-in-cats-associated-with-heart-failure
#9
J Novo Matos, N Pereira, T Glaus, L Wilkie, K Borgeat, J Loureiro, J Silva, V Law, A Kranjc, D J Connolly, V Luis Fuentes
BACKGROUND: Cats with hypertrophic cardiomyopathy (HCM) and congestive heart failure (CHF) can have resolution of both left ventricular hypertrophy and CHF. OBJECTIVES: To describe the clinical characteristics of cats with transient myocardial thickening (TMT) and CHF compared with a control population of cats without resolution of HCM. ANIMALS: A total of 21 cats with TMT, 21 cats with HCM. METHODS: Retrospective study...
December 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29204239/wilkie-s-syndrome
#10
Renato Farina, Pietro Valerio Foti, Giuseppe Cocuzza, Valeria Costanzo, Giuliana Costanzo, Alessandro Conti, Alfredo Torcitto, Monica Pennisi
Superior mesenteric artery syndrome, also known as Wilkie's syndrome, is a rare vascular disease caused by the anomalous course of the superior mesenteric artery arising from the abdominal aorta with a smaller angle than the norm (<22°). The reduced angle compresses the structures situated between the aorta and the superior mesenteric artery, such as the duodenum and left renal vein; this can determine painful crises, intestinal subocclusions, and left varicocele. This syndrome can be congenital or acquired...
December 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/29180823/huwe1-variants-cause-dominant-x-linked-intellectual-disability-a-clinical-study-of-21-patients
#11
Stéphanie Moortgat, Siren Berland, Ingvild Aukrust, Isabelle Maystadt, Laura Baker, Valerie Benoit, Alfonso Caro-Llopis, Nicola S Cooper, François-Guillaume Debray, Laurence Faivre, Thatjana Gardeitchik, Bjørn I Haukanes, Gunnar Houge, Emma Kivuva, Francisco Martinez, Sarju G Mehta, Marie-Cécile Nassogne, Nina Powell-Hamilton, Rolph Pfundt, Monica Rosello, Trine Prescott, Pradeep Vasudevan, Barbara van Loon, Christine Verellen-Dumoulin, Alain Verloes, Charlotte von der Lippe, Emma Wakeling, Andrew O M Wilkie, Louise Wilson, Amy Yuen, Ddd Study, Karen J Low, Ruth A Newbury-Ecob
Whole-gene duplications and missense variants in the HUWE1 gene (NM_031407.6) have been reported in association with intellectual disability (ID). Increased gene dosage has been observed in males with non-syndromic mild to moderate ID with speech delay. Missense variants reported previously appear to be associated with severe ID in males and mild or no ID in obligate carrier females. Here, we report the largest cohort of patients with HUWE1 variants, consisting of 14 females and 7 males, with 15 different missense variants and one splice site variant...
November 27, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29178891/rationale-and-design-for-sharehd-a-quality-improvement-collaborative-to-scale-up-shared-haemodialysis-care-for-patients-on-centre-based-haemodialysis
#12
James Fotheringham, Tania Barnes, Louese Dunn, Sonia Lee, Steven Ariss, Tracey Young, Stephen J Walters, Paul Laboi, Andy Henwood, Rachel Gair, Martin Wilkie
BACKGROUND: The study objective is to assess the effectiveness and economic impact of a structured programme to support patient involvement in centre-based haemodialysis and to understand what works for whom in what circumstances and why. It implements a program of Shared Haemodialysis Care (SHC) that aims to improve experience and outcomes for those who are treated with centre-based haemodialysis, and give more patients the confidence to dialyse independently both at centres and at home...
November 24, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29177918/disruptive-behavior-treatment-progress-as-a-function-of-therapy-focus-and-youth-diagnosis-in-a-community-mental-health-setting
#13
Daniel P Wilkie, David C Cicero, Charles W Mueller
Monthly disruptive behavior treatment progress for 613 youth ages 7-18 receiving intensive in-home services was examined. Multilevel modeling indicated carrying a depressive mood diagnosis predicted less disruptive behavior progress compared to youth with only externalizing diagnoses. Paradoxically, more monthly focus on disruptive behavior treatment targets predicted lower concurrent progress ratings, while greater focus on depressive mood targets predicted greater disruptive behavior progress for youth with a depressive mood diagnosis...
November 25, 2017: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/29171135/feasibility-and-pilot-study-of-an-intervention-to-support-active-lifestyles-in-youth-with-type-1-diabetes-the-activpals-study
#14
Fiona Mitchell, Louise Wilkie, Kenneth Robertson, John J Reilly, Alison Kirk
BACKGROUND: Evidence suggests youth with type 1 diabetes (T1D) have lower levels of physical activity (PA) than the general population. The ActivPals intervention aimed to support youth with T1D to lead an active lifestyle. METHODS: Twenty youth aged 7 to 16 years with T1D were recruited to a pilot randomized controlled trial. PA and quality of life (QoL) were measured using Actigraph GT3X+ monitor and Pediatric QoL scales at baseline and 1-month follow-up. A two-way, mixed ANOVA showed indicative effects of the intervention...
November 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29145089/arsenic-removal-from-as-hyperaccumulator-pteris-vittata-biomass-coupling-extraction-with-precipitation
#15
Evandro B da Silva, Letuzia M de Oliveira, Ann C Wilkie, Yungen Liu, Lena Q Ma
Proper disposal of As-hyperaccumulator Pteris vittata biomass (Chinese brake fern) enhances its application in phytoremediation. The goal of this study was to optimize As removal from P. vittata (PV) biomass by testing different particle sizes, extractants, extraction times and solid-to-liquid ratios. PV biomass was extracted using different extractants followed by different Mg-salts to recover soluble As via precipitation. Water-soluble As in PV biomass varied from 6.8% to 61% of total As depending on extraction time, with 99% of As being arsenate (AsV)...
October 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/29145006/a-cross-disciplinary-evaluation-of-evidence-for-multipollutant-effects-on-cardiovascular-disease
#16
REVIEW
Thomas J Luben, Barbara J Buckley, Molini M Patel, Tina Stevens, Evan Coffman, Kristen M Rappazzo, Elizabeth O Owens, Erin P Hines, Danielle Moore, Kyle Painter, Ryan Jones, Laura Datko-Williams, Adrien A Wilkie, Meagan Madden, Jennifer Richmond-Bryant
BACKGROUND: The current single-pollutant approach to regulating ambient air pollutants is effective at protecting public health, but efficiencies may be gained by addressing issues in a multipollutant context since multiple pollutants often have common sources and individuals are exposed to more than one pollutant at a time. OBJECTIVE: We performed a cross-disciplinary review of the effects of multipollutant exposures on cardiovascular effects. METHODS: A broad literature search for references including at least two criteria air pollutants (particulate matter [PM], ozone [O3], oxides of nitrogen, sulfur oxides, carbon monoxide) was conducted...
November 13, 2017: Environmental Research
https://www.readbyqxmd.com/read/29141808/what-should-a-person-with-relapsing-remitting-multiple-sclerosis-know-focus-group-and-survey-data-of-a-risk-knowledge-questionnaire-rikno-2-0
#17
C Heesen, J Pöttgen, A C Rahn, K Liethmann, J Kasper, L Vahter, J Drulovic, A Van Nunen, D Wilkie, Y Beckmann, F Paul, S Köpke, A Giordano, A Solari
BACKGROUND: Risk knowledge is relevant to make informed decisions in multiple sclerosis (MS). The risk knowledge questionnaire for relapsing-remitting MS (RIKNO 1.0) was developed and piloted in Germany. OBJECTIVE: To produce a revised RIKNO 2.0 questionnaire using mixed methodology in a European setting. METHODS: The questionnaire was translated in seven languages. MS patient and health professional (HP) expert feedback was obtained from Germany, Italy, Estonia, Serbia, and the UK...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29132032/influence-of-body-size-metabolic-rate-and-life-history-stage-on-the-uptake-and-excretion-of-the-lampricide-3-trifluoromethyl-4-nitrophenol-tfm-by-invasive-sea-lampreys-petromyzon-marinus
#18
Laura R Tessier, Tristan A F Long, Michael P Wilkie
Invasive sea lamprey (Petromyzon marinus) are controlled in the Great Lakes using the lampricide 3-trifluoromethyl-4-nitrophenol (TFM), which is applied to streams infested with larval lamprey. However, lamprey that survive treatments (residuals) remain a challenge because they may subsequently undergo metamorphosis into parasitic juvenile animals that migrate downstream to the Great Lakes, where they feed on important sport and commercial fishes. The goal of this study was to determine if body size and life stage could potentially influence sea lamprey tolerance to TFM by influencing patterns of TFM uptake and elimination...
October 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29131749/patient-centred-care-a-call-to-action-for-wound-management
#19
E Lindsay, R Renyi, P Wilkie, F Valle, W White, V Maida, H Edwards, D Foster
No abstract text is available yet for this article.
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29131348/the-value-of-contrast-enhanced-laparoscopic-ultrasound-during-robotic-assisted-surgery-for-primary-colorectal-cancer
#20
Signe Bremholm Ellebaek, Claus Wilki Fristrup, Torsten Pless, Peiman Hossein Poornoroozy, Per Vadgaard Andersen, Bassam Mahdi, Michael Bau Mortensen
AIM: The aim of this study was to assess the potential clinical value of contrast enhanced laparoscopic ultrasonography (CE-LUS) as a screening modality for liver metastases during robotic assisted surgery for primary colorectal cancer (CRC). METHOD: A prospective, descriptive (feasibility) study including 50 consecutive patients scheduled for robotic assisted surgery for primary CRC. CE-LUS was performed by 2 experienced specialists. Only patients without metastatic disease were included...
November 13, 2017: Journal of Clinical Ultrasound: JCU
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