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https://www.readbyqxmd.com/read/28186488/control-of-immune-ligands-by-members-of-a-cytomegalovirus-gene-expansion-suppresses-natural-killer-cell-activation
#1
Ceri Alan Fielding, Michael P Weekes, Luis V Nobre, Eva Ruckova, Gavin S Wilkie, Joao A Paulo, Chiwen Chang, Nicolás M Suárez, James A Davies, Robin Antrobus, Richard J Stanton, Rebecca J Aicheler, Hester Nichols, Borek Vojtesek, John Trowsdale, Andrew J Davison, Steven P Gygi, Peter Tomasec, Paul J Lehner, Gavin Wg Wilkinson
The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel NK cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1,300 cell surface and ~7,200 whole cell proteins, we demonstrate that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors...
February 10, 2017: ELife
https://www.readbyqxmd.com/read/28186088/current-status-of-immunotherapy-for-gastrointestinal-stromal-tumor
#2
REVIEW
Y Tan, J C Trent, B A Wilky, D A Kerr, A E Rosenberg
Gastrointestinal stromal tumors (GIST) contain tumor-infiltrating immune cells and their presence provides an opportunity and rationale for developing effective forms of immunotherapy. The types of tumor-infiltrating inflammatory cells and relevant immune checkpoint inhibitors are the focus of active investigation. The most numerous tumor-infiltrating inflammatory cells are tumor-associated macrophages (TAMs) and CD3+ T cells. Studies have shown that patients with GISTs that harbor increased numbers of CD3+ T cells have better outcomes...
February 10, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28173767/musculoskeletal-pain-and-co-morbid-insomnia-in-adults-a-population-study-of-the-prevalence-and-impact-on-restricted-social-participation
#3
Shula Baker, John McBeth, Carolyn A Chew-Graham, Ross Wilkie
BACKGROUND: Comorbidity is common in patients consulting in primary care. Musculoskeletal pain and insomnia each increase the risk of the other. Co-occurrence may pose an increased burden on well-being. However, the prevalence and impact of co-existing pain and insomnia in adults living in the community who may present to primary care is unclear. The aim of this study was to report the prevalence of pain and insomnia in adults registered with primary care, and to examine the impact of co-occurrence on social activities...
February 7, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28162517/-283-beta2-adrenergic-receptor-gene-polymorphisms-and-haplotypes-associate-with-chronic-pain-in-sickle-cell-disease
#4
E Jhun, Y He, Y Yao, D Wilkie, R Molokie, J Wang
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162515/-280-interleukin-1alpha-rs1800587-associates-with-chronic-non-crisis-pain-in-sickle-cell-disease
#5
X Hu, E Jhun, Y Yao, Y He, R Molokie, D Wilkie, Z Wang
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162473/-245-vasopressin-snp-is-related-to-sickle-cell-acute-care-utilization-for-pain
#6
K Roach, E Jhun, Y He, M Suarez, Y Yao, R Molokie, Z Wang, D Wilkie
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162413/-187-normative-values-for-quantitative-sensory-testing-in-african-americans
#7
M Ezenwa, Y Yao, M Suarez, Z Zhao, J Carrasco, V Angulo, D Shuey, K Roach, Z Wang, R Molokie, D Wilkie
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162382/-157-the-association-of-sickle-cell-related-stigma-with-physical-and-emotional-symptoms-in-patients-with-sickle-cell-pain
#8
M Ezenwa, Y Yao, R Molokie, Z Wang, M Suarez, Z Zhao, J Carrasco, V Angulo, D Shuey, K Roach, G Oraifo, D Wilkie
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162358/-550-a-hot-cold-old-new-model-for-vulvodynia-an-exploratory-study-using-eastern-and-western-traditions
#9
J Schlaeger, H Cai, X Nenggui, A Steffen, W Lin, D Wilkie
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28153962/can-we-make-better-use-of-checklists-to-improve-peritoneal-dialysis-outcomes
#10
EDITORIAL
Martin Wilkie
No abstract text is available yet for this article.
January 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28138148/many-faces-of-smchd1
#11
Andrew O M Wilkie
The chromatin scaffolding protein SMCHD1 (structural maintenance of chromosomes flexible hinge domain containing 1) was previously shown to have diverse roles in X-chromosome inactivation, imprinting and double-strand break repair, and mutations in SMCHD1 contribute to a type of muscular dystrophy. Now, development of the nose and eyes is added to its list of functions.
January 31, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28100057/wilkie%C3%A2-s-syndrome
#12
Carlos Oliva-Fonte, Cristina Fernández Rey, Javier Pereda Rodríguez, Ana María González-Fernández
We report the case of a 14 year-old woman, who presents epigastric abdominal pain, abundant vomits and an important abdominal distension. Previously, she presented similar episodes. She has not any significant prior medical history. CT is performed and the imaging findings are consistent with Wilkie´s syndrome. Wilkie´s syndrome is a rare condition, that results from a intestinal obstruction caused by third portion duodenal compression between the abdominal aorta and the superior mesenteric artery. When the angle between both structures diminishes and the distance between the SMA and the aorta decreases (the most diagnostic value), duodenal obstruction occurs...
January 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28100055/superior-mesenteric-artery-syndrome-an-uncommon-cause-of-intestinal-obstruction
#13
José Barquín Yagüez, Pedro Abadía Barnó, Juan Carlos García Pérez
Superior mesenteric artery syndrome, also Wilkie's syndrome, is an uncommon cause of upper intestinal obstruction. It includes compression of the third duodenal portion by the aorta and the overlying superior mesenteric artery when the angle formed by these two structures becomes smaller. It may result from significant weight loss or abdominal trauma, or may have a congenital origin. Treatment for most cases is conservative.
January 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28093877/a-shovel-ready-solution-to-fill-the-nursing-data-gap-in-the-interdisciplinary-clinical-picture
#14
Gail M Keenan, Karen Dunn Lopez, Vanessa E C Sousa, Janet Stifter, Tamara G R Macieira, Andrew D Boyd, Yingwei Yao, T Heather Herdman, Sue Moorhead, Anna McDaniel, Diana J Wilkie
PURPOSE: To critically evaluate 2014 American Academy of Nursing (AAN) call-to-action plan for generating interoperable nursing data. DATA SOURCES: Healthcare literature. DATA SYNTHESIS: AAN's plan will not generate the nursing data needed to participate in big data science initiatives in the short term because Logical Observation Identifiers Names and Codes and Systematized Nomenclature of Medicine - Clinical Terms are not yet ripe for generating interoperable data...
January 16, 2017: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/28074536/use-of-an-intravenous-sclerosing-foam-3-sodium-tetradecyl-sulfate-for-treatment-of-orbital-varix-in-a-dog
#15
Rebecca S Saunders, Brian A Scansen, Stephen S Jung, Hooman Khabiri, David A Wilkie
A 6-month-old intact male Standard Dachshund was referred for evaluation of a soft tissue swelling above the right eye. Examination of the right eye revealed mild lateral deviation of the globe, normal vision, and a dorsonasal soft tissue swelling. Examination of the posterior segment was normal. Dual-phase computed tomography angiography was consistent with an orbital varix of the angularis oculi and right dorsal external ophthalmic veins with no evidence of arterial involvement. Treatment involved fluoroscopically guided coil embolization of the venous outflow with nine platinum microcoils, followed by sclerotherapy of the varix using 1...
January 10, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28031660/a-rare-case-of-gastric-mantle-cell-lymphoma-causing-superior-mesenteric-artery-syndrome-in-an-adult
#16
Shailesh Garg, Alain Derzie
Superior mesenteric artery (SMA) syndrome or Wilkie syndrome is a rare condition that arises when the distal third of the duodenum becomes trapped between the SMA and the abdominal aorta causing intestinal obstruction. It is most commonly described in adolescents and rarely in adult patients. We present an interesting case of an adult who developed SMA syndrome from an uncommon gastric mantle cell lymphoma that was recognized early and treated surgically.
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28018897/patient-centered-tablet-application-for-improving-medication-adherence-after-a-drug-eluting-stent
#17
Vicki Shah, Anandu Dileep, Carolyn Dickens, Vicki Groo, Betty Welland, Jerry Field, Matthew Baumann, Jose D Flores, Adhir Shroff, Zhongsheng Zhao, Yingwei Yao, Diana J Wilkie, Andrew D Boyd
BACKGROUND/AIMS: This study's objective was to evaluate a patient-centered educational electronic tablet application, "My Interventional Drug-Eluting Stent Educational App" (MyIDEA) to see if there was an increase in patient knowledge about dual antiplatelet therapy (DAPT) and medication possession ratio (MPR) compared to treatment as usual. METHODS: In a pilot project, 24 elderly (≥50 years old) research participants were recruited after a drug-eluting stent...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/28003296/feasibility-of-a-web-based-suicide-awareness-programme-for-asian-american-college-students
#18
Heeseung Choi, Hanjong Park, Marie L Suarez, Chang Park, Zhongsheng Zhao, Diana J Wilkie
OBJECTIVE: The Truth about Suicide video has been widely used but has never been empirically tested regarding its cultural appropriateness for Asian Americans. The purpose of the study was to determine the feasibility of using the video in a web-based suicide awareness programme for Asian American and non-Hispanic white college students. METHODS: A cross-sectional, comparative, web-based study was conducted with 227 Asian Americans and 204 non-Hispanic whites at a university in the Midwest region of the USA...
December 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/28002621/acupuncture-and-acupressure-in-labor
#19
REVIEW
Judith M Schlaeger, Elizabeth M Gabzdyl, Jeanie L Bussell, Nobuari Takakura, Hiroyoshi Yajima, Miho Takayama, Diana J Wilkie
Acupuncture and acupressure, 2 modalities of Traditional Chinese Medicine, are based on reducing pain and symptoms of disease through balancing yin and yang. Acupuncture and acupressure have been used in China for reduction of labor pain, labor augmentation, and other intrapartum indications for more than 2 millennia. This article presents a review of the current literature that has addressed the effects of acupuncture and acupressure on intrapartum events. Studies of acupuncture have demonstrated that acupuncture may reduce labor pain, the use of pharmacologic agents, the use of forceps and vacuum-assisted births, and the length of labor...
January 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28002540/gallbladder-carcinoma-a-rare-cause-of-pyloric-duodenal-stenosis
#20
Zizi Niculescu, Victoria Ulmeanu, Mihaela Maria Ghinea, Liliana Mocanu, Costin Niculescu, Mircea Grigorian
Pyloric duodenal stenosis is usually caused by pyloric, juxtapyloric or duodenal ulcer, or by postbulbar ulcer. Gallbladder cancer (GBC), duodenal diverticula, annular pancreas and superior mesenteric artery syndrome (Wilkie's syndrome) are rare causes of pyloric duodenal stenosis. The case of a 66-year-old female patient is presented. The patient was admitted to hospital presenting anorexia, repeated alimentary vomiting, epigastric pain, and weight loss. Objective clinical examination upon admission: clapotage à jeun is present, triggered by tapping the epigastric region...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
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