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https://www.readbyqxmd.com/read/28932601/the-role-of-sodium-bicarbonate-in-the-management-of-some-toxic-ingestions
#1
REVIEW
Aibek E Mirrakhimov, Taha Ayach, Aram Barbaryan, Goutham Talari, Romil Chadha, Adam Gray
Adverse reactions to commonly prescribed medications and to substances of abuse may result in severe toxicity associated with increased morbidity and mortality. According to the Center for Disease Control, in 2013, at least 2113 human fatalities attributed to poisonings occurred in the United States of America. In this article, we review the data regarding the impact of systemic sodium bicarbonate administration in the management of certain poisonings including sodium channel blocker toxicities, salicylate overdose, and ingestion of some toxic alcohols and in various pharmacological toxicities...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28905302/non-health-care-facility-medication-errors-associated-with-hormones-and-hormone-antagonists-in-the-united-states
#2
Pranav Magal, Henry A Spiller, Marcel J Casavant, Thitphalak Chounthirath, Nichole L Hodges, Gary A Smith
INTRODUCTION: Hormones and hormone antagonists are frequently associated with medication errors and may result in important adverse outcomes. The purpose of this study is to investigate non-health care facility (non-HCF) medication errors associated with hormones and hormone antagonists in the United States (US). METHODS: A retrospective analysis of National Poison Data System data was conducted to identify characteristics and trends of unintentional non-HCF therapeutic errors involving hormones and hormone antagonists among individuals of all ages from 2000 to 2012...
September 13, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28890656/effects-of-teaching-health-care-workers-on-diagnosis-and-treatment-of-pesticide-poisonings-in-uganda
#3
REVIEW
Claudia Sibani, Kristian Kjaer Jessen, Bircan Tekin, Victoria Nabankema, Erik Jørs
BACKGROUND: Acute pesticide poisoning in developing countries is a considerable problem, requiring diagnosis and treatment. This study describes how training of health care workers in Uganda affects their ability to diagnose and manage acute pesticide poisoning. METHOD: A postintervention cross-sectional study was conducted using a standardized questionnaire. A total of 326 health care workers in Uganda were interviewed on knowledge and handling of acute pesticide poisoning...
2017: Environmental Health Insights
https://www.readbyqxmd.com/read/28882025/shipping-amounts-of-olive-flounder-from-jejudo-and-events-of-acute-food-poisoning-by-kudoa-septempunctata-in-2015-korea-an-ecological-study
#4
Jong-Myon Bae
Objectives: There are debates on Kudoa septempunctata as a pathogenic agent causing acute food poisoning because the reproducibility of experimental evidences is in doubt. If K. septempunctata were one of causal agent of acute food poisoning, the more intake of oliver flounder infected by K. septempuctata, the more occurrence of events diagnosed as Kudoa food poisoning. The aim was to evaluate an association between shipping amounts of olive flounder from Jejudo (amounts) and events of Kudoa food poisoning (events)...
September 6, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28858755/calls-to-florida-poison-control-centers-about-mercury-trends-over-2003-2013
#5
Matthew O Gribble, Aniruddha Deshpande, Wendy B Stephan, Candis M Hunter, Richard S Weisman
OBJECTIVE: The aim of this analysis was to contrast trends in exposure-report calls and informational queries (a measure of public interest) about mercury to the Florida Poison Control Centers over 2003-2013. MATERIALS AND METHODS: Poison-control specialists coded calls to Florida Poison Control Centers by substance of concern, caller demographics, and whether the call pertained to an exposure event or was an informational query. For the present study, call records regarding mercury were de-identified and provided along with daily total number of calls for statistical analysis...
August 28, 2017: Environmental Research
https://www.readbyqxmd.com/read/28857697/isoniazid-toxicosis-in-dogs-137-cases-2004-2014
#6
Dustin R Schmid, Justine A Lee, Tina A Wismer, Pedro Paulo V P Diniz, Robert J Murtaugh
OBJECTIVE To establish the minimum toxic dose of isoniazid in dogs, characterize the clinical signs and outcomes for dogs following isoniazid ingestion, and determine whether IV administration of pyridoxine to dogs with isoniazid toxicosis is protective against death. DESIGN Retrospective case series. ANIMALS 137 dogs with isoniazid toxicosis. PROCEDURES The electronic database of the American Society for the Prevention of Cruelty to Animals Animal Poison Control Center was reviewed from January 2004 through December 2014 to identify dogs with isoniazid toxicosis...
September 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28771645/opportunity-for-collaboration-between-radiation-injury-treatment-network-centers-and-medical-toxicology-specialists
#7
Elizabeth Davlantes, Samuel Shartar, Jennifer Venero, Alaina Steck, Amelia Langston, Ziad N Kazzi
OBJECTIVES: The Radiation Injury Treatment Network (RITN) comprises >50 centers across the United States that are poised to care for victims of a radiation emergency. The network is organized around bone marrow transplant centers because these facilities excel in both radiation medicine and the care of patients with severe bone marrow depression. A radiation emergency may cause not only irradiation from an external source but also internal contamination with radioactive material. Because medical toxicologists are trained in radiation injury management and have expertise in the management of internal contamination, RITN centers may benefit from partnerships with medical toxicology resources, which may be located at academic medical centers, hospital inpatient clinical services, outpatient clinics, or poison control centers...
August 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28771411/measurement-challenges-at-low-blood-lead-levels
#8
Kathleen L Caldwell, Po-Yung Cheng, Jeffery M Jarrett, Amir Makhmudov, Kathryn Vance, Cynthia D Ward, Robert L Jones, Mary E Mortensen
In 2012, the Centers for Disease Control and Prevention (CDC) adopted its Advisory Committee on Childhood Lead Poisoning Prevention recommendation to use a population-based reference value to identify children and environments associated with lead hazards. The current reference value of 5 μg/dL is calculated as the 97.5th percentile of the distribution of blood lead levels (BLLs) in children 1 to 5 years old from 2007 to 2010 NHANES data. We calculated and updated selected percentiles, including the 97.5th percentile, by using NHANES 2011 to 2014 blood lead data and examined demographic characteristics of children whose blood lead was ≥90th percentile value...
August 2017: Pediatrics
https://www.readbyqxmd.com/read/28763391/spatial-surveillance-of-childhood-lead-exposure-in-a-targeted-screening-state-an-application-of-generalized-additive-models-in-denver-colorado
#9
Kevin Berg, Stephanie Kuhn, Mike Van Dyke
CONTEXT: The targeted nature of Colorado's childhood lead screening program presents several analytical issues that complicate routine epidemiologic surveillance. OBJECTIVES: To analyze spatial patterns of childhood lead exposure among children younger than 6 years, identifying areas of increased risk along with associated covariates. METHODS: We analyzed a spatial case-control data set of childhood lead poisoning using generalized additive models...
September 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28763382/economic-valuation-of-selected-illnesses-in-environmental-public-health-tracking
#10
Ying Zhou, Tursynbek Nurmagambetov, Matthew McCord, Wan-Hsiang Hsu
BACKGROUND: In benefit-cost analysis of public health programs, health outcomes need to be assigned monetary values so that different health endpoints can be compared and improvement in health can be compared with cost of the program. There are 2 major approaches for estimating economic value of illnesses: willingness to pay (WTP) and cost of illness (COI). In this study, we compared these 2 approaches and summarized valuation estimates for 3 health endpoints included in the Centers for Disease Control and Prevention's National Environmental Public Health Tracking Network-asthma, carbon monoxide (CO) poisoning, and lead poisoning...
September 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28762882/acute-pesticide-related-illness-among-farmworkers-barriers-to-reporting-to-public-health-authorities
#11
Joanne Bonnar Prado, Prakash R Mulay, Edward J Kasner, Heidi K Bojes, Geoffrey M Calvert
Farmworkers are at high risk of acute occupational pesticide-related illness (AOPI) and AOPI surveillance is vital to preventing these illnesses. Data on such illnesses are collected and analyzed to identify high-risk groups, high-risk pesticides, and root causes. Interventions to address these risks and root causes include farmworker outreach, education, and regulation. Unfortunately, it is well known that AOPI is underreported, meaning that the true burden of this condition remains unknown. This article reviews the barriers to reporting of farmworker AOPI to public health authorities and provides some practical solutions...
2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28753046/levetiracetam-in-toxic-seizures
#12
Ted Lee, Brandon J Warrick, Preeyaporn Sarangarm, Robert L Alunday, Silas Bussmann, Susan C Smolinske, Steven A Seifert
BACKGROUND/OBJECTIVES: The use of levetiracetam (LEV) in the management of drug-induced seizures has not been systematically investigated. Repetitive and continuous seizures that do not respond to benzodiazepines require second line therapy. Levetiracetam has a unique receptor binding site, rapid absorption, no known cardiac effects at therapeutic doses, and is theoretically a good candidate for use in drug-induced seizures. We evaluate the safety of LEV and its association with seizure cessation in this retrospective chart review of patients who received LEV as a control agent in drug-induced seizures...
July 28, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28753044/severe-bark-scorpion-envenomation-in-adults
#13
Ayrn D O'Connor, Angela Padilla-Jones, Anne-Michelle Ruha
INTRODUCTION: The preponderance of medical literature regarding severe bark scorpion envenomation describes pediatric patients; however, the majority (>66%) of annual poison center calls pertain to adults. This retrospective review sought to evaluate the clinical manifestations of adults with severe Centruroides sculpturatus envenomation and determine if significant morbidity occurred. METHODS: This is a retrospective review of adults presenting to a single tertiary referral center with Grade-III or Grade-IV scorpion envenomation from 1 January 2007 to 3 March 2013...
July 28, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28741370/non-health-care-facility-anticonvulsant-medication-errors-in-the-united-states
#14
Emily A DeDonato, Henry A Spiller, Marcel J Casavant, Thitphalak Chounthirath, Nichole L Hodges, Gary A Smith
INTRODUCTION: This study provides an epidemiological description of non-health care facility medication errors involving anticonvulsant drugs. METHODS: A retrospective analysis of National Poison Data System data was conducted on non-health care facility medication errors involving anticonvulsant drugs reported to US Poison Control Centers from 2000 through 2012. RESULTS: During the study period, 108,446 non-health care facility medication errors involving anticonvulsant pharmaceuticals were reported to US Poison Control Centers, averaging 8342 exposures annually...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28741126/an-increase-in-dietary-supplement-exposures-reported-to-us-poison-control-centers
#15
Nisha Rao, Henry A Spiller, Nichole L Hodges, Thiphalak Chounthirath, Marcel J Casavant, Amrit K Kamboj, Gary A Smith
INTRODUCTION: The objective of this study was to investigate the epidemiology of dietary supplement exposures in the USA. METHODS: A retrospective analysis was conducted of out-of-hospital dietary supplement exposures reported to the National Poison Data System from 2000 through 2012. RESULTS: There were 274,998 dietary supplement exposures from 2000 through 2012. The annual rate of dietary supplement exposures per 100,000 population increased by 46...
July 24, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28734939/acetaminophen-apap-hepatotoxicity-isn-t-it-time-for-apap-to-go-away
#16
REVIEW
William M Lee
Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever around the world. At the same time, APAP can cause dose-related hepatocellular necrosis, responsible for nearly 500 deaths annually in the United States (US) alone, as well as 100,000 calls to US Poison Control Centers, 50,000 emergency room visits and 10,000 hospitalisations per year. As an over-the-counter and prescription product (with opioids), APAP toxicity dwarfs all other prescription drugs as a cause of acute liver failure in the US and Europe, but it is not regulated in any significant way...
July 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28710607/evaluation-of-a-food-and-drug-administration-mandate-to-limit-acetaminophen-in-prescription-combination-products
#17
David Goldberger, David Vearrier
INTRODUCTION: In 2014, the US Food and Drug Administration limited the production of prescription acetaminophen-opioid combination products to 325 mg per dose unit. The goal of this mandate was to decrease the likelihood of unintentional acetaminophen hepatotoxicity. This study was designed to determine if this federal regulation has succeeded in reducing unintentional acetaminophen-induced hepatotoxicity from opioid combination products. METHODS: Using data from the National Poison Data System (NPDS), we analyzed all calls to US Poison Control Centers in the years 2013 and 2015 for acetaminophen-opioid combination product exposures...
July 14, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28705022/evaluation-of-dose-and-outcomes-for-pediatric-vilazodone-ingestions
#18
Christopher E Gaw, Henry A Spiller, Jason L Russell, Thiphalak Chounthirath, Gary A Smith
BACKGROUND: Selective serotonin reuptake inhibitor (SSRI) exposures among children younger than 6 years of age are generally well tolerated. Vilazodone is an SSRI with partial agonism at the 5-HT1A receptor with demonstrated clinical efficacy for depression whose off-label usage is likely to increase. Recent evidence suggests that unintentional ingestion of vilazodone in children under 6 years old is associated with more severe clinical effects than other SSRIs. We chose to evaluate dose and outcomes for pediatric vilazodone ingestions...
July 14, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28691871/non-health-care-facility-medication-errors-resulting-in-serious-medical-outcomes
#19
Nichole L Hodges, Henry A Spiller, Marcel J Casavant, Thiphalak Chounthirath, Gary A Smith
OBJECTIVE: The objective of this study is to provide an epidemiologic analysis of medication errors occurring outside of health care facilities that result in serious medical outcomes (defined by the National Poison Database System as "moderate effect," "major effect," "death," or "death, indirect report"). METHODS: National Poison Database System data from 2000 through 2012 were used for this retrospective analysis of non-health care facility medication errors...
July 10, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28659131/childhood-pesticide-poisoning-in-zhejiang-china-a-retrospective-analysis-from-2006-to-2015
#20
Aziguli Yimaer, Guangdi Chen, Meibian Zhang, Lifang Zhou, Xinglin Fang, Wei Jiang
BACKGROUND: Pesticide poisoning in children has been a serious public health issue around the world, especially in the developing countries where agriculture is still one of the largest economic sectors. The purpose of this study was to analyze epidemiological characteristics of acute pesticide poisoning in children from Zhejiang province, China. METHODS: The pesticide poisoning cases for children were retrieved from Occupational Disease Surveillance and Reporting System, Zhejiang Provincial Center for Disease Control and Prevention, China...
June 28, 2017: BMC Public Health
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