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https://www.readbyqxmd.com/read/29116999/treatment-outcome-of-combined-continuous-venovenous-hemofiltration-and-hemoperfusion-in-acute-paraquat-poisoning-a-prospective-controlled-trial
#1
Changbin Li, Dayong Hu, Wen Xue, Xinhua Li, Zhen Wang, Zisheng Ai, Yaxiang Song, Xinying Liu, Jiafeng Cheng, Shuling Fan, Limin Zhao, Liya Wang, Chandra Mohan, Ai Peng
OBJECTIVES: To investigate whether combined continuous venovenous hemofiltration and hemoperfusion among paraquat-poisoned patients would improve survival. DESIGN: Prospective, controlled interventional study over 4 years. SETTING: Single, tertiary, academic medical center. PATIENTS: We recruited patients admitted to Shanghai Tenth People's Hospital within 48 hours after paraquat ingestion. Exclusions were under 14 years old, ingestion of paraquat with other toxicants, pregnant, a history of chronic pulmonary disease, psychosis, hyperthyroidism, or diabetes with impaired liver or renal function...
November 7, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29095808/harmful-algal-bloom-associated-illnesses-in-humans-and-dogs-identified-through-a-pilot-surveillance-system-new-york-2015
#2
Mary Figgatt, James Hyde, David Dziewulski, Eric Wiegert, Scott Kishbaugh, Grant Zelin, Lloyd Wilson
Cyanobacteria, also known as blue-green algae, are photosynthetic, aquatic organisms found in fresh, brackish, and marine water around the world (1). Rapid proliferation and accumulation of potentially toxin-producing cyanobacteria characterize one type of harmful algal bloom (HAB). HABs have the potential to cause illness in humans and animals (2,3); however, the epidemiology of these illnesses has not been well characterized. Statewide in 2015, a total of 139 HABs were identified in New York, 97 (70%) of which were confirmed through laboratory analysis; 77 independent beach closures were ordered at 37 beaches on 20 different bodies of water...
November 3, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29094867/electronic-cigarette-exposure-calls-to-wisconsin-poison-control-centers-2010%C3%A2-2015
#3
Debora Weiss, Carrie D Tomasallo, Jon G Meiman, Paul D Creswell, Paul C Melstrom, David D Gummin, Disa J Patel, Nancy T Michaud, Heather A Sebero, Henry A Anderson
BACKGROUND: E-cigarettes are battery-powered devices that deliver nicotine and flavorings by aerosol and have been marketed in the United States since 2007. Because e-cigarettes have increased in popularity, toxicity potential from device misuse and malfunction also has increased. National data indicate that during 2010–2014, exposure calls to US poison control centers increased only 0.3% for conventional cigarette exposures, whereas calls increased 41.7% for e-cigarette exposures. METHODS: We characterized cigarette and e-cigarette exposure calls to the Wisconsin Poison Center January 1, 2010 through October 10, 2015...
December 2016: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29032872/assessing-bleeding-risk-in-patients-with-intentional-overdoses-of-novel-antiplatelet-and-anticoagulant-medications
#4
Michael Levine, Michael C Beuhler, Anthony Pizon, F Lee Cantrel, Meghan B Spyres, Frank LoVecchio, Aaron B Skolnik, Daniel E Brooks
STUDY OBJECTIVE: In recent years, the use of novel anticoagulants and antiplatelet agents has become widespread. Little is known about the toxicity and bleeding risk of these agents after acute overdose. The primary objective of this study is to evaluate the relative risk of all bleeding and major bleeding in patients with acute overdose of novel antiplatelet and anticoagulant medications. METHODS: This study is a retrospective study of acute ingestion of apixaban, clopidogrel, ticlopidine, dabigatran, edoxaban, prasugrel, rivaroxaban, and ticagrelor reported to 7 poison control centers in 4 states during a 10-year span...
October 9, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28977311/toxic-exposures-in-children-involving-legally-and-illegally-commercialized-household-sanitizers
#5
Alessandra Marcuz de Souza Campos, Fábio Bucaretchi, Luciane Cristina Rodrigues Fernandes, Carla Borrasca Fernandes, Eduardo Mello de Capitani, Ana Raquel Medeiros Beck
OBJECTIVES: To analyze and to compare clinical repercussions of accidents involving legally and illegally commercialized household sanitizers in children under 7 years of age. METHODS: A descriptive cross-sectional design was used to collect data from electronic database of a regional Poison Control Center during one year. Data were analyzed by means of descriptive non-parametric statistics and association tests. Results: The sample had 737 reported cases. Most of the accidents occurred with children under 3 years of age (median: 1 year of age; interquartile interval: 1-3 years of age), at home (92...
January 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/28952373/antipyretic-medication-exposures-among-young-children-reported-to-us-poison-centers-2000-2015
#6
Sofia Rakowsky, Henry A Spiller, Marcel J Casavant, Thiphalak Chounthirath, Nichole L Hodges, Eun Hye Kim, Gary A Smith
This study used the National Poison Data System database to retrospectively analyze the characteristics and medical outcomes of exposures to antipyretic medications involving children younger than 6 years in the United States. From 2000 through 2015, United States Poison Control Centers recorded an average of 74 387 antipyretic exposures annually among children younger than 6 years. Most exposures involved ibuprofen (55.1%) or acetaminophen (40.1%). From 2000 to 2009, the number of exposures increased by 73...
March 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28932601/the-role-of-sodium-bicarbonate-in-the-management-of-some-toxic-ingestions
#7
REVIEW
Aibek E Mirrakhimov, Taha Ayach, Aram Barbaryan, Goutham Talari, Romil Chadha, Adam Gray
Adverse reactions to commonly prescribed medications and to substances of abuse may result in severe toxicity associated with increased morbidity and mortality. According to the Center for Disease Control, in 2013, at least 2113 human fatalities attributed to poisonings occurred in the United States of America. In this article, we review the data regarding the impact of systemic sodium bicarbonate administration in the management of certain poisonings including sodium channel blocker toxicities, salicylate overdose, and ingestion of some toxic alcohols and in various pharmacological toxicities...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28905302/non-health-care-facility-medication-errors-associated-with-hormones-and-hormone-antagonists-in-the-united-states
#8
Pranav Magal, Henry A Spiller, Marcel J Casavant, Thitphalak Chounthirath, Nichole L Hodges, Gary A Smith
INTRODUCTION: Hormones and hormone antagonists are frequently associated with medication errors and may result in important adverse outcomes. The purpose of this study is to investigate non-health care facility (non-HCF) medication errors associated with hormones and hormone antagonists in the United States (US). METHODS: A retrospective analysis of National Poison Data System data was conducted to identify characteristics and trends of unintentional non-HCF therapeutic errors involving hormones and hormone antagonists among individuals of all ages from 2000 to 2012...
September 13, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28890656/effects-of-teaching-health-care-workers-on-diagnosis-and-treatment-of-pesticide-poisonings-in-uganda
#9
REVIEW
Claudia Sibani, Kristian Kjaer Jessen, Bircan Tekin, Victoria Nabankema, Erik Jørs
BACKGROUND: Acute pesticide poisoning in developing countries is a considerable problem, requiring diagnosis and treatment. This study describes how training of health care workers in Uganda affects their ability to diagnose and manage acute pesticide poisoning. METHOD: A postintervention cross-sectional study was conducted using a standardized questionnaire. A total of 326 health care workers in Uganda were interviewed on knowledge and handling of acute pesticide poisoning...
2017: Environmental Health Insights
https://www.readbyqxmd.com/read/28882025/relationship-between-shipping-amounts-of-olive-flounder-aquacultured-from-jejudo-and-the-reported-events-of-acute-food-poisoning-by-kudoa-septempunctata-in-2015-south-korea-an-ecological-study
#10
Jong-Myon Bae
OBJECTIVES: Confirmation of Kudoa septempunctata (K. septempunctata) as the pathogenic agent causing acute food poisoning remains under debate owing to inconsistencies in the reproducibility of experimental evidence. Higher intake of olive flounder infected with K. septempunctata would result in increased diagnosis of food poisoning by K. septempunctata, if the latter was one of the causal agents of acute food poisoning. The aim was to evaluate the relationship between the shipping amount of olive flounder aquacultured from Jejudo and the incidence of K...
2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28858755/calls-to-florida-poison-control-centers-about-mercury-trends-over-2003-2013
#11
Matthew O Gribble, Aniruddha Deshpande, Wendy B Stephan, Candis M Hunter, Richard S Weisman
OBJECTIVE: The aim of this analysis was to contrast trends in exposure-report calls and informational queries (a measure of public interest) about mercury to the Florida Poison Control Centers over 2003-2013. MATERIALS AND METHODS: Poison-control specialists coded calls to Florida Poison Control Centers by substance of concern, caller demographics, and whether the call pertained to an exposure event or was an informational query. For the present study, call records regarding mercury were de-identified and provided along with daily total number of calls for statistical analysis...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28857697/isoniazid-toxicosis-in-dogs-137-cases-2004-2014
#12
Dustin R Schmid, Justine A Lee, Tina A Wismer, Pedro Paulo V P Diniz, Robert J Murtaugh
OBJECTIVE To establish the minimum toxic dose of isoniazid in dogs, characterize the clinical signs and outcomes for dogs following isoniazid ingestion, and determine whether IV administration of pyridoxine to dogs with isoniazid toxicosis is protective against death. DESIGN Retrospective case series. ANIMALS 137 dogs with isoniazid toxicosis. PROCEDURES The electronic database of the American Society for the Prevention of Cruelty to Animals Animal Poison Control Center was reviewed from January 2004 through December 2014 to identify dogs with isoniazid toxicosis...
September 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28771645/opportunity-for-collaboration-between-radiation-injury-treatment-network-centers-and-medical-toxicology-specialists
#13
Elizabeth Davlantes, Samuel Shartar, Jennifer Venero, Alaina Steck, Amelia Langston, Ziad N Kazzi
OBJECTIVES: The Radiation Injury Treatment Network (RITN) comprises >50 centers across the United States that are poised to care for victims of a radiation emergency. The network is organized around bone marrow transplant centers because these facilities excel in both radiation medicine and the care of patients with severe bone marrow depression. A radiation emergency may cause not only irradiation from an external source but also internal contamination with radioactive material. Because medical toxicologists are trained in radiation injury management and have expertise in the management of internal contamination, RITN centers may benefit from partnerships with medical toxicology resources, which may be located at academic medical centers, hospital inpatient clinical services, outpatient clinics, or poison control centers...
August 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28771411/measurement-challenges-at-low-blood-lead-levels
#14
Kathleen L Caldwell, Po-Yung Cheng, Jeffery M Jarrett, Amir Makhmudov, Kathryn Vance, Cynthia D Ward, Robert L Jones, Mary E Mortensen
In 2012, the Centers for Disease Control and Prevention (CDC) adopted its Advisory Committee on Childhood Lead Poisoning Prevention recommendation to use a population-based reference value to identify children and environments associated with lead hazards. The current reference value of 5 μg/dL is calculated as the 97.5th percentile of the distribution of blood lead levels (BLLs) in children 1 to 5 years old from 2007 to 2010 NHANES data. We calculated and updated selected percentiles, including the 97.5th percentile, by using NHANES 2011 to 2014 blood lead data and examined demographic characteristics of children whose blood lead was ≥90th percentile value...
August 2017: Pediatrics
https://www.readbyqxmd.com/read/28763391/spatial-surveillance-of-childhood-lead-exposure-in-a-targeted-screening-state-an-application-of-generalized-additive-models-in-denver-colorado
#15
Kevin Berg, Stephanie Kuhn, Mike Van Dyke
CONTEXT: The targeted nature of Colorado's childhood lead screening program presents several analytical issues that complicate routine epidemiologic surveillance. OBJECTIVES: To analyze spatial patterns of childhood lead exposure among children younger than 6 years, identifying areas of increased risk along with associated covariates. METHODS: We analyzed a spatial case-control data set of childhood lead poisoning using generalized additive models...
September 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28763382/economic-valuation-of-selected-illnesses-in-environmental-public-health-tracking
#16
Ying Zhou, Tursynbek Nurmagambetov, Matthew McCord, Wan-Hsiang Hsu
BACKGROUND: In benefit-cost analysis of public health programs, health outcomes need to be assigned monetary values so that different health endpoints can be compared and improvement in health can be compared with cost of the program. There are 2 major approaches for estimating economic value of illnesses: willingness to pay (WTP) and cost of illness (COI). In this study, we compared these 2 approaches and summarized valuation estimates for 3 health endpoints included in the Centers for Disease Control and Prevention's National Environmental Public Health Tracking Network-asthma, carbon monoxide (CO) poisoning, and lead poisoning...
September 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28762882/acute-pesticide-related-illness-among-farmworkers-barriers-to-reporting-to-public-health-authorities
#17
Joanne Bonnar Prado, Prakash R Mulay, Edward J Kasner, Heidi K Bojes, Geoffrey M Calvert
Farmworkers are at high risk of acute occupational pesticide-related illness (AOPI) and AOPI surveillance is vital to preventing these illnesses. Data on such illnesses are collected and analyzed to identify high-risk groups, high-risk pesticides, and root causes. Interventions to address these risks and root causes include farmworker outreach, education, and regulation. Unfortunately, it is well known that AOPI is underreported, meaning that the true burden of this condition remains unknown. This article reviews the barriers to reporting of farmworker AOPI to public health authorities and provides some practical solutions...
2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28753046/levetiracetam-in-toxic-seizures
#18
Ted Lee, Brandon J Warrick, Preeyaporn Sarangarm, Robert L Alunday, Silas Bussmann, Susan C Smolinske, Steven A Seifert
BACKGROUND/OBJECTIVES: The use of levetiracetam (LEV) in the management of drug-induced seizures has not been systematically investigated. Repetitive and continuous seizures that do not respond to benzodiazepines require second line therapy. Levetiracetam has a unique receptor binding site, rapid absorption, no known cardiac effects at therapeutic doses, and is theoretically a good candidate for use in drug-induced seizures. We evaluate the safety of LEV and its association with seizure cessation in this retrospective chart review of patients who received LEV as a control agent in drug-induced seizures...
July 28, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28753044/severe-bark-scorpion-envenomation-in-adults
#19
Ayrn D O'Connor, Angela Padilla-Jones, Anne-Michelle Ruha
INTRODUCTION: The preponderance of medical literature regarding severe bark scorpion envenomation describes pediatric patients; however, the majority (>66%) of annual poison center calls pertain to adults. This retrospective review sought to evaluate the clinical manifestations of adults with severe Centruroides sculpturatus envenomation and determine if significant morbidity occurred. METHODS: This is a retrospective review of adults presenting to a single tertiary referral center with Grade-III or Grade-IV scorpion envenomation from 1 January 2007 to 3 March 2013...
July 28, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28741370/non-health-care-facility-anticonvulsant-medication-errors-in-the-united-states
#20
Emily A DeDonato, Henry A Spiller, Marcel J Casavant, Thitphalak Chounthirath, Nichole L Hodges, Gary A Smith
INTRODUCTION: This study provides an epidemiological description of non-health care facility medication errors involving anticonvulsant drugs. METHODS: A retrospective analysis of National Poison Data System data was conducted on non-health care facility medication errors involving anticonvulsant drugs reported to US Poison Control Centers from 2000 through 2012. RESULTS: During the study period, 108,446 non-health care facility medication errors involving anticonvulsant pharmaceuticals were reported to US Poison Control Centers, averaging 8342 exposures annually...
January 1, 2017: Human & Experimental Toxicology
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