Alexandre Porcello, Farid Hadjab, Maryam Ajouaou, Virginie Philippe, Robin Martin, Philippe Abdel-Sayed, Nathalie Hirt-Burri, Corinne Scaletta, Wassim Raffoul, Lee Ann Applegate, Eric Allémann, Olivier Jordan, Alexis Laurent
While many injectable viscosupplementation products are available for osteoarthritis (OA) management, multiple hydrogel functional attributes may be further optimized for efficacy enhancement. The objective of this study was to functionally benchmark four commercially available hyaluronan-based viscosupplements (Ostenil, Ostenil Plus, Synvisc, and Innoryos), focusing on critical (rheological, lubricative, adhesive, and stability) attributes. Therefore, in vitro and ex vivo quantitative characterization panels (oscillatory rheology, rotational tribology, and texture analysis with bovine cartilage) were used for hydrogel product functional benchmarking, using equine synovial fluid as a biological control...
October 9, 2023: Gels