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https://www.readbyqxmd.com/read/29133143/pathologic-and-clinical-characteristics-of-early-onset-renal-cell-carcinoma
#1
Tyler Clemmensen, Andres Matoso, Tiffany Graham, Win Shun Lai, Soroush Rais-Bahrami, Jennifer Gordetsky
The majority of RCCs occur within the 7th decade of life, uncommonly arising in adults ≤46years. We reviewed the clinicopathologic features of early-onset renal cell carcinoma (RCC) and evaluated the role of immunohistochemistry (IHC) in potentially identifying diagnoses of newly recognized RCC subtypes that may have been previously misclassified. A retrospective review was performed from 2011-2016 for cases of RCC. Early-onset RCC was defined as ≤46years of age. Clinicopathologic findings and hematoxylin and eosin (H&E) slides were reviewed on early-onset RCC patients...
November 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/29118224/exceptional-response-to-temsirolimus-in-a-metastatic-clear-cell-renal-cell-carcinoma-with-an-early-novel-mtor-activating-mutation
#2
Juan Francisco Rodríguez-Moreno, María Apellaniz-Ruiz, Juan María Roldan-Romero, Ignacio Durán, Luis Beltrán, Cristina Montero-Conde, Alberto Cascón, Mercedes Robledo, Jesus García-Donas, Cristina Rodríguez-Antona
mTOR pathway inhibitors are important drugs for the treatment of advanced renal cell carcinoma (RCC). However, no valid predictive markers have been identified to guide treatment selection and identify patients who are sensitive to these drugs. Mutations activating the mTOR pathway have been suggested to predict response; however, their predictive value is still unclear. Here, we present the genomic and functional characterization of a patient with metastatic clear cell RCC (ccRCC) who experienced a partial response to temsirolimus after a poor response to 2 previous lines of treatment...
November 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29108248/prognostic-relevance-of-androgen-receptor-expression-in-renal-cell-carcinomas
#3
Sebastian Foersch, Mario Schindeldecker, Martina Keith, Katrin E Tagscherer, Aurélie Fernandez, Philipp J Stenzel, Sascha Pahernik, Markus Hohenfellner, Peter Schirmacher, Wilfried Roth, Stephan Macher-Goeppinger
Background: Despite rapid discoveries in molecular biology of renal cell carcinoma (RCC) and advances in systemic targeted therapies, development of new diagnostic and therapeutic strategies is urgently needed. The androgen receptor (AR) has been shown to hold prognostic and predicitve value in several malignancies. Here, we studied a possible association between AR expression and prognosis in patients with RCCs. Results: Low AR expression levels were associated with occurrence of distant metastasis and higher tumor stage in papillary and clear-cell RCCs...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104112/unclassified-hemangioma-like-renal-cell-carcinoma-a-potential-diagnostic-pitfall
#4
Kanika Taneja, Sohrab Arora, Craig G Rogers, Nilesh S Gupta, Liang Cheng, Sean R Williamson
Recently, rare renal cell carcinomas (RCC) have been reported to closely mimic hemangioma; however, these have been largely recognizable as clear cell RCC. Conversely, true hemangiomas of the kidney are also increasingly recognized. We report a 62-year-old woman who underwent partial nephrectomy for a hemangioma-like RCC without appreciable clear cell morphology. Immunohistochemistry revealed luminal structures that stained positively for cytokeratin (CK), CK7, carbonic anhydrase IX, PAX8, and high molecular weight keratin (HMWK), admixed with a CD34, CD31, and ERG-positive complex network of vessels...
November 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/29099381/-adenoma-metanephric-report-of-2-cases-and-bibliographic-review
#5
Enrique Rodríguez-Zarco, Ana Vallejo-Benítez, Francisco Javier Farfán-López, Ángel Vilches-Arenas, Sofía Pereira-Gallardo, Francisco Javier Vázquez-Ramírez
OBJECTIVE: Two cases of metanephric adenoma are presented, a rare benign renal tumor, and a literature review is done under the current WHO classification (2016). METHODS: Standard histopathological study was performed with hematoxylin-eosin and immunohistochemistry to analyze the expression of WT, Vimentin, Racemase, CK7, CD10 and RCC. RESULTS: Neoplasms of 3 and 4.5 cm, histologically, exhibiting tubulopapillary architecture. There was no evidence of significant nuclear atypia and mitotic figures...
November 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29079986/percutaneous-image-guided-core-biopsy-of-solid-renal-masses-analysis-of-safety-efficacy-pathologic-interpretation-and-clinical-significance
#6
Nisha Alle, Nelly Tan, Julie Huss, Jiatoi Huang, Allan Pantuck, Steven S Raman
PURPOSE: To determine the efficacy, safety and clinical utility of CT and US-guided percutaneous renal mass biopsy. MATERIALS AND METHODS: A retrospective IRB-approved, HIPAA-compliant study of a cohort of 183 consecutive patients who underwent percutaneous, CT or US-guided renal mass biopsy (RMB) from March 2002 through December 2012 was performed. RMB was performed in 183 consecutive patients for suspected solid renal mass of whom 14/183 (7.7%) were excluded because biopsies were performed at an outside institution, medical records were incomplete, or lesions were poorly visualized...
October 27, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29073630/microrna-30a-5p-inhibits-the-growth-of-renal-cell-carcinoma-by-modulating-grp78-expression
#7
Changlin Wang, Licheng Cai, Jing Liu, Gang Wang, Haoming Li, Xiaoxiong Wang, Wanhai Xu, Minghua Ren, Li Feng, Pinghuang Liu, Cheng Zhang
BACKGROUND/AIMS: MiR-30a-5p, a member of the microRNA-30 family (miR-30), is known to function as a tumor suppressor in several different cancers. However, the expression levels, biological function, and underlying mechanisms of miR-30a-5p in renal cell carcinoma (RCC) remain unclear. Glucose-regulated protein78 (GRP78) is a common cancer biomarker and promotes the growth and survival of cancer cells. The expression of GRP78 has been reported to be modulated by miR-30a in neurons. In this study, the expression profile of miR-30a-5p in clear cell renal cell carcinoma (ccRCC) and its effect on ccRCC through regulating GRP78 expression was investigated...
October 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29050853/cytoplasmic-expression-of-cd133-stemness-marker-is-associated-with-tumor-aggressiveness-in-clear-cell-renal-cell-carcinoma
#8
Leili Saeednejad Zanjani, Zahra Madjd, Maryam Abolhasani, Yvonne Andersson, Arezoo Rasti, Ahmad Shariftabrizi, Mojgan Asgari
Prominin-1 (CD133) is one of the most commonly used markers for cancer stem cells (CSCs), which are characterized by their ability for self-renewal and tumorigenicity. However, the clinical and prognostic significance of CSCs in renal cell carcinoma (RCC) remains unclear. The aim of this study was to investigate the expression patterns and prognostic significance of the cancer stem cell marker CD133 in different histological subtypes of RCC. CD133 expression was evaluated using immunohistochemistry in 193 well-defined renal tumor samples on tissue microarrays, including 136 (70...
October 16, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28993942/cannabinoid-receptor-2-as-a-novel-target-for-promotion-of-renal-cell-carcinoma-prognosis-and-progression
#9
Jianfeng Wang, Yunze Xu, Liangsong Zhu, Yun Zou, Wen Kong, Baijun Dong, Jiwei Huang, Yonghui Chen, Wei Xue, Yiran Huang, Jin Zhang
PURPOSE: Renal cell carcinoma (RCC) is the most common malignancy of urogenital system, and patients with RCC may face a poor prognosis. However, limited curable therapeutic options are currently available. The aim of this study is to investigate the role of Cannabinoid receptor 2 (CB2) in RCC progression. METHODS: Immunohistochemistry was to investigate the expression pattern of CB2 in 418 RCC tissues and explore its prognostic function in RCC patients. Furthermore, the role of used CB2 si-RNA knockdown and inhibited by AM630, a CB2 inverse agonist, on cell proliferation, migration, and cell cycle of RCC cell lines in vitro was also investigated...
October 9, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28986088/expression-of-tyrosine-kinase-receptor-axl-is-associated-with-worse-outcome-of-metastatic-renal-cell-carcinomas-treated-with-sunitinib
#10
Luís Eduardo Zucca, Mariana Andozia Morini Matushita, Renato José da Silva Oliveira, Cristovam Scapulatempo-Neto, Marcos Alves de Lima, Guilherme Gomes Ribeiro, Cristiano Ribeiro Viana, Flavio Mavignier Cárcano, Rui Manuel Reis
BACKGROUND: Renal cell carcinoma (RCC) represents 2%-3% of all cancers of the Western countries. Currently, sunitinib, a receptor tyrosine kinase inhibitor, particularly of PDGF and VEGF receptors, is the first-line therapy for metastatic RCC (mRCC), with significant improvement in clinical outcome. However, there is a lack of predictive biomarkers of sunitinib response. Recently, others and our group suggested that the receptor tyrosine kinase AXL may modify the response to sunitinib...
October 3, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28983605/ldha-promotes-tumor-metastasis-by-facilitating-epithelial%C3%A2-mesenchymal-transition-in-renal-cell-carcinoma
#11
Juping Zhao, Xin Huang, Zhaoping Xu, Jun Dai, Hongchao He, Yu Zhu, Haofei Wang
Previous studies have indicated that high expression of lactate dehydrogenase A (LDHA) exists in many human cancers. Recently, several reports showed that silencing or inhibition of LDHA could suppress metastasis of human cancer including renal cell carcinoma (RCC). However, the mechanism remains unknown. The role of LDHA in RCC migration and invasion was investigated using immunohistochemistry, western blotting, Transwell and scratch assays, and in vivo experiment. The influence of LDHA on the Warburg effect was also investigated by LDHA activity and lactate production assay...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28975715/data-independent-acquisition-based-quantitative-proteomic-analysis-reveals-potential-biomarkers-of-kidney-cancer
#12
Yimeng Song, Lijun Zhong, Juntuo Zhou, Min Lu, Tianying Xing, Lulin Ma, Jing Shen
PURPOSE: Renal cell carcinoma (RCC) is a malignant and metastatic cancer with 95% mortality, and clear cell RCC (ccRCC) is the most observed among the five major subtypes of RCC. Specific biomarkers that can distinguish cancer tissues from adjacent normal tissues should be developed to diagnose this disease in early stages and conduct a reliable prognostic evaluation. EXPERIMENTAL DESIGN: Data-independent acquisition (DIA) strategy has been widely employed in proteomic analysis because of various advantages, including enhanced protein coverage and reliable data acquisition...
October 4, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28949976/prcc-tfe3-dual-fusion-fish-assay-a-new-method-for-identifying-prcc-tfe3-renal-cell-carcinoma-in-paraffin-embedded-tissue
#13
Lei Xiong, Xiancheng Chen, Ning Liu, Zhen Wang, Baolei Miao, Weidong Gan, Dongmei Li, Hongqian Guo
PRCC-TFE3 renal cell carcinoma (RCC) is one of the most common types of Xp11.2 translocation renal cell carcinoma (tRCC), of which the diagnosis mainly relies on reverse transcription-polymerase chain reaction (RT-PCR) or chromosomal analysis in fresh frozen samples. Herein, we developed a new dual-fusion fluorescence in situ hybridization (FISH) probe to succinctly identify PRCC-TFE3 RCC in paraffin-embedded tissue. We immunohistochemically analyzed TFE3 and cathepsin K expression in 23 cases of Xp11.2 tRCC which had been confirmed by break-apart TFE3 FISH probe...
2017: PloS One
https://www.readbyqxmd.com/read/28936621/expression-of-inflammatory-lipopolysaccharide-binding-protein-lbp-predicts-the-progression-of-conventional-renal-cell-carcinoma-a-short-report
#14
Gyula Kovacs, Lehel Peterfi, Nelli Farkas, Andras Javorhazy, Csaba Pusztai, Arpad Szanto
BACKGROUND: The mortality of conventional renal cell carcinoma (RCC) correlates directly with the presence or postoperative development of metastases. The aim of this study was to identify new markers associated with the postoperative progression of conventional RCC. METHODS: Tissue microarrays (TMA) of conventional RCC from a cohort of 414 patients were analysed by immunohistochemistry for expression of the lipopolysaccharide binding protein (LBP), which was identified as a candidate biomarker through Affymetrix U133 Plus 2...
September 21, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28927090/downregulation-of-pdcd4-by-mir-21-suppresses-tumor-transformation-and-proliferation-in-a-nude-mouse-renal-cancer-model
#15
Haixin Yuan, Shiyong Xin, Yaoping Huang, Yingfan Bao, Hao Jiang, Liqing Zhou, Xiaoqiang Ren, Liang Li, Qian Wang, Jianguo Zhang
Programmed cell death 4 (PDCD4) is known to suppress neoplastic transformation, cell proliferation and metastasis, and to be downregulated by microRNA-21 (miR-21) in renal cell carcinoma (RCC) cell lines and tissues. The aim of the present study was to investigate the roles of and association between PDCD4 and miR-21 in a nude mouse renal cancer model. A total of 24 BALB/c male nude mice were randomly assigned into the following three groups: Negative control (NC; n=8), miR-21 inhibitor (n=8) and miR-21 mimic (n=8)...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28918350/expression-and-functional-characterization-of-the-bnip3-protein-in-renal-cell-carcinomas
#16
Stephan Macher-Goeppinger, Martina Keith, Gencay Hatiboglu, Markus Hohenfellner, Peter Schirmacher, Wilfried Roth, Katrin E Tagscherer
BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1. Here, we studied a possible association of BNIP3 expression and the prognosis of patients with renal cell carcinomas (RCCs) and examined the functional relevance of BNIP3 in the regulation of cell survival and apoptosis of renal carcinoma cells. BNIP3 expression was determined by immunohistochemistry in RCC tumor tissue samples of 569 patients using a tissue microarray...
December 2017: Translational Oncology
https://www.readbyqxmd.com/read/28898443/re-evaluation-of-33-unclassified-eosinophilic-renal-cell-carcinomas-in-young-patients
#17
Yunjie Li, Victor E Reuter, Andres Matoso, George J Netto, Jonathan I Epstein, Pedram Argani
AIMS: We sought to determine if some unclassified renal cell carcinomas (RCCs) in children and young adults that are characterized by predominantly eosinophilic cytoplasm are related to the recently described succinate dehydrogenase (SDH)-deficient RCC, fumarate hydratase (FH)-deficient RCC, or eosinophilic solid and cystic (ESC) RCC. METHODS AND RESULTS: We reviewed 33 unclassified RCCs with predominantly eosinophilic cytoplasm in patients age 35 years or younger...
September 12, 2017: Histopathology
https://www.readbyqxmd.com/read/28827104/comprehensive-evaluation-of-prostate-specific-membrane-antigen-expression-in-the-vasculature-of-renal-tumors-implications-for-imaging-studies-and-prognostic-role
#18
Sophia Spatz, Yuri Tolkach, Klaus Jung, Carsten Stephan, Jonas Busch, Bernhard Ralla, Anja Rabien, Georg Feldmann, Peter Brossart, Ralph A Bundschuh, Hojjat Ahmadzadehfar, Markus Essler, Marieta Toma, Stefan C Müller, Jörg Ellinger, Stefan Hauser, Glen Kristiansen
PURPOSE: Prostate-specific membrane antigen (PSMA) is expressed by endothelium of many tumors. The aim of the study was to find a rationale for PSMA-based imaging and to investigate the prognostic role of vascular PSMA expression in patients with renal cell carcinoma (RCC). MATERIALS AND METHODS: Two-hundred fifty seven patients with RCC were included with a median follow-up exceeding 10.0 years. PSMA expression on the tumor vessels was detected by immunohistochemistry...
August 18, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28807339/primary-collision-tumors-of-the-kidney-composed-of-oncocytoma-and-papillary-renal-cell-carcinoma-a-review
#19
REVIEW
Zulfia McCroskey, Sue J Sim, Andrew A Selzman, Alberto G Ayala, Jae Y Ro
BACKGROUND: There are well known cases of hybrid tumors of chromophobe renal cell carcinoma (RCC) and oncocytoma in kidney, where both tumors have the same cell of origin - intercalated cell of the collecting duct. However, collision tumors composed of neoplasms originating from different cell lineages such as oncocytoma and papillary RCC are extremely rare. Herein, we made a collective literature review of reported cases of collision tumors composed of oncocytoma and papillary RCC, adding a case that we recently experienced...
August 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28807336/programmed-death-1-pd-1-receptor-pd-1-ligand-pd-l1-expression-in-fumarate-hydratase-deficient-renal-cell-carcinoma
#20
Reza Alaghehbandan, Jan Stehlik, Kiril Trpkov, Cristina Magi-Galluzzi, Enric Condom Mundo, Maria Pane Foix, Daniel Berney, Mathilde Sibony, Saul Suster, Abbas Agaimy, Delia Perez Montiel, Kristyna Pivovarcikova, Kvetoslava Michalova, Ondrej Daum, Ondrej Ondic, Pavla Rotterova, Martin Dusek, Milan Hora, Michal Michal, Ondrej Hes
Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare and aggressive tumor affecting mostly younger patients. This is the first study to assess the expression of programmed death-1 (PD-1) receptor/PD-1 ligand (PD-L1) in FH-RCC. Formalin-fixed paraffin-embedded samples from 13 FH-RCCs collected in an international multi-institutional study, were evaluated by immunohistochemistry (IHC) for PD-1/PD-L1 reactivity in tumor cells and tumor infiltrating lymphocytes (TILs). PD-1/PD-L1 expression was further evaluated by qPCR...
August 2017: Annals of Diagnostic Pathology
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