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https://www.readbyqxmd.com/read/28687956/cd163-positive-cancer-cells-are-potentially-associated-with-high-malignant-potential-in-clear-cell-renal-cell-carcinoma
#1
Chaoya Ma, Hasita Horlad, Koji Ohnishi, Takenobu Nakagawa, Sohsuke Yamada, Shohei Kitada, Takanobu Motoshima, Tomomi Kamba, Toshiyuki Nakayama, Naohiro Fujimoto, Motohiro Takeya, Yoshihiro Komohara
CD163 is preferentially expressed by monocyte/macrophages; however, recent studies using immunohistochemistry (IHC) have reported that some cancer cells also express CD163. In the present IHC study, we investigated CD163 staining of cancer cells and macrophages in clear cell renal cell carcinoma (ccRCC) tissues and determined the relationship between cancer cell CD163 expression and clinical prognosis in patients with ccRCC. IHC for CD163 was performed in ccRCC tissues from 103 patients. CD163-positive cancer cells were detected in 35% of the patients (36/103); however, the positive signals on cancer cells were significantly lower than those on macrophages...
July 7, 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/28677779/kindlin%C3%A2-2-promotes-clear-cell-renal-cell-carcinoma-progression-through-the-wnt-signaling-pathway
#2
Muhan Li, Xuelian Pei, Guoliang Wang, Jun Zhan, Juan Du, Hao Jiang, Yan Tang, Hongquan Zhang, Huiying He
Kindlin‑2 is an integrin-interacting, FERM-domain containing protein, which plays a critical role in tumor progression. However, the specific role of Kindlin‑2 in renal cell carcinoma (RCC) progression has not been described. In this study we investigated the role of Kindlin‑2 in progression of clear cell RCC (CCRCC), which is the most common RCC subtype, and its underlying mechanisms. Immunohistochemistry studies show that expression of Kindlin‑2 in CCRCC is positively correlated with tumor grade, and Kindlin‑2 expression in advanced CCRCC with lymph node metastasis was greater than in localized CCRCC...
July 4, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28672019/phosphatase-and-tensin-homolog-pten-expression-on-oncologic-outcome-in-renal-cell-carcinoma-a-systematic-review-and-meta-analysis
#3
Lu Tang, Xintao Li, Yu Gao, Luyao Chen, Liangyou Gu, Jianwen Chen, Xiangjun Lyu, Yu Zhang, Xu Zhang
The phosphatase and tensin homolog (PTEN) gene is suggested to be a dormant tumor suppressor. However, the prognostic value of the loss of PTEN expression in renal cell carcinoma (RCC) remains controversial. Therefore, we conducted a meta-analysis to evaluate the association of PTEN expression with the clinicopathological presentations and outcomes of patients with RCC through immunohistochemistry staining analysis. We systematically searched for relevant studies in PubMed, Web of Science, and Embase until March 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28654655/the-prognostic-value-of-bap1-pbrm1-ps6-pten-tgase2-pd-l1-ca9-psma-and-ki-67-tissue-markers-in-localized-renal-cell-carcinoma-a-retrospective-study-of-tissue-microarrays-using-immunohistochemistry
#4
Sung Han Kim, Weon Seo Park, Eun Young Park, Boram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
OBJECTIVE: To assess the prognostic roles of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue biomarkers in localized renal cell carcinoma (RCC). METHODS: Patients who underwent a nephrectomy during 1992-2015 and had a primary specimen of their kidney tumor were included. The nine tissue biomarkers were immunohistochemically stained on tissue microarrays of RCC, and the semi-quantitative H-score, including intensity score, was used to grade the sample...
2017: PloS One
https://www.readbyqxmd.com/read/28646318/primary-renal-paragangliomas-and-renal-neoplasia-associated-with-pheochromocytoma-paraganglioma-analysis-of-von-hippel-lindau-vhl-succinate-dehydrogenase-sdhx-and-transmembrane-protein-127-tmem127
#5
Sounak Gupta, Jun Zhang, Dragana Milosevic, John R Mills, Stefan K Grebe, Steven C Smith, Lori A Erickson
Alterations of von Hippel-Lindau (VHL), succinate dehydrogenase (SDHX), and TMEM127 have been associated with the development of pheochromocytomas (PCs) and paragangliomas (PGLs) and are also associated with the development of renal neoplasms. This study involved 2 primary renal PGL and 12 cases of PC/PGL with associated renal neoplasia with a mean follow up of 74 months. Germline VHL and SDHX mutation status was obtained from the medical record. Immunohistochemistry for SDHB and mutation analysis for TMEM127 was performed, in addition to analysis of The Cancer Genome Atlas datasets for SDHX and TMEM127 mutated renal cell carcinomas (RCCs)...
June 23, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28551621/the-expression-of-bts-2-enhances-cell-growth-and-invasiveness-in-renal-cell-carcinoma
#6
Quoc Thang Pham, Naohide Oue, Yuji Yamamoto, Yoshinori Shigematsu, Yohei Sekino, Naoya Sakamoto, Kazuhiro Sentani, Naohiro Uraoka, Mamata Tiwari, Wataru Yasui
BACKGROUND: Renal cell carcinoma (RCC) is one of the most common types of cancer in developed countries. Bone marrow stromal cell antigen 2 (BST2) gene, which encodes BST2 transmembrane glycoprotein, is overexpressed in several cancer types. In the present study, we analyzed the expression and function of BST2 in RCC. MATERIALS AND METHODS: BST2 expression was analyzed by immunohistochemistry in 123 RCC cases. RNA interference was used to inhibit BST2 expression in a RCC cell line...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28524003/targeting-the-programmed-cell-death-1-pathway-in-genitourinary-tumors-current-progress-and-future-perspectives
#7
Rodolfo Montironi, Liang Cheng, Holger Moch, Antonio Lopez-Beltran, Marina Scarpelli, Francesco Massari, Michelangelo Fiorentino, Chiara Ciccarese, Michael Koch, Hristos Z Kaimakliotis, Lisha Wang, Roberto Pili, Steven A Mann
Immune checkpoint inhibitors have revolutionized the treatment many malignancies with over a dozen new United States Food and Drug Administration (FDA) approvals in the past six years. Due to the combination of potent treatment success and potentially deadly adverse effects from immune checkpoint inhibitors, gathering prognostic and predictive information about FDA-indicated tumors is prudent. PD-L1 expression is a poor prognostic factor and predictive of better responses from both PD-1 and PD-L1 inhibitors in a variety of tumor types including RCC and urothelial carcinoma...
May 18, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28503092/management-of-gene-variants-of-unknown-significance-analysis-method-and-risk-assessment-of-the-vhl-mutation-p-p81s-c-241c-t
#8
REVIEW
Daniela Alosi, Marie Luise Bisgaard, Sophie Nowak Hemmingsen, Lotte Nylandsted Krogh, Hanne Birte Mikkelsen, Marie Louise Mølgaard Binderup
BACKGROUND: Evaluation of the pathogenicity of a gene variant of unknown significance (VUS) is crucial for molecular diagnosis and genetic counseling, but can be challenging. This is especially so in phenotypically variable diseases, such as von Hippel-Lindau disease (vHL). vHL is caused by germline mutations in the VHL gene, which predispose to the development of multiple tumors such as central nervous system hemangioblastomas and renal cell carcinoma (RCC). OBJECTIVE: We propose a method for the evaluation of VUS pathogenicity through our experience with the VHL missense mutation c...
February 2017: Current Genomics
https://www.readbyqxmd.com/read/28464919/the-role-of-apoptosis-repressor-with-a-card-domain-arc-in-the-therapeutic-resistance-of-renal-cell-carcinoma-rcc-the-crucial-role-of-arc-in-the-inhibition-of-extrinsic-and-intrinsic-apoptotic-signalling
#9
Csaba Toth, Sarah Funke, Vanessa Nitsche, Anna Liverts, Viktoriya Zlachevska, Marcia Gasis, Constanze Wiek, Helmut Hanenberg, Csaba Mahotka, Peter Schirmacher, Sebastian Heikaus
BACKGROUND: Renal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One important anti-apoptotic factor that is strongly overexpressed in RCCs and known to inhibit both apoptotic pathways is ARC (apoptosis repressor with a CARD domain). METHODS: Expression and subcellular distribution of ARC in RCC tissue samples and RCC cell lines were determined by immunohistochemistry and fluorescent immunohistochemistry, respectively...
May 2, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28449664/distinct-immunophenotypes-and-prognostic-factors-in-renal-cell-carcinoma-with-sarcomatoid-differentiation-a-systematic-study-of-19-immunohistochemical-markers-in-42-cases
#10
Wenjuan Yu, Yuewei Wang, Yanxia Jiang, Wei Zhang, Yujun Li
BACKGROUND: Renal cell carcinoma (RCC) with sarcomatoid differentiation is a relatively rare tumor containing both carcinoma and sarcomatoid components. However, there has not been a systemic study on immunophenotypes of renal cell carcinoma with sarcomatoid differentiation, especially using some renal specific immunohistochemical markers. In this study, we aimed to comprehensively investigate the distinct immunophenotypes of RCC with sarcomatoid differentiation to analyze the pathogenesis of sarcomatoid differentiation and identify new prognostic factors in RCC with sarcomatoid differentiation...
April 27, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28416106/categorizing-renal-oncocytic-neoplasms-on-core-needle-biopsy-a-morphologic-and-immunophenotypic-study-of-144-cases-with-clinical-follow-up-alderman-ma-daignault-s-wolf-js-jr-palapattu-gs-weizer-az-hafez-ks-kunju-lp-wu-aj-hum-pathol-september-2016-55-1-10
#11
Oleksandr N Kryvenko
There is limited literature on renal oncocytic neoplasms diagnosed on core biopsy. All renal oncocytic neoplasm core biopsies from 2006 to 2013 were, retrospectively, reviewed. Morphologic features and an immunohistochemical panel of CK7, c-KIT, and S100A1 were assessed. Concordance with resection diagnosis, statistical analysis including a random forest classification, and follow-up were recorded. The postimmunohistochemical diagnoses of 144 renal oncocytic core biopsies were favor oncocytoma (67%), favor renal cell carcinoma (RCC) (12%), and cannot exclude RCC (21%)...
June 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28415646/combination-of-immunohistochemistry-fish-and-rt-pcr-shows-high-incidence-of-xp11-translocation-rcc-comparison-of-three-different-diagnostic-methods
#12
Hyun Jung Lee, Dong Hoon Shin, Gyu You Noh, Young Keum Kim, Ahrong Kim, Nari Shin, Jung Hee Lee, Kyung Un Choi, Jee Yeon Kim, Chang Hun Lee, Mee Young Sol, Seo Hee Rha, Sung Woo Park
We evaluated the frequency of translocation renal cell carcinoma (RCC) by reverse transcription polymerase chain reaction (RT-PCR) and how well the TFE3 immunoreactivity is concordant with TFE3 gene translocation status proved by fluorescence in situ hybridization (FISH) assay and RT-PCR. TFE3 and Cathepsin K expression was analyzed by immunohistochemistry in 185 RCC cases, and 48 cases either of more than weak expression of TFE3 or of positivity for Cathepsin K were done for FISH analysis and RT-PCR. All the RT-PCR positive cases were confirmed by cloning and sequencing...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404922/adipophilin-as-prognostic-biomarker-in-clear-cell-renal-cell-carcinoma
#13
Yuri Tolkach, Christine Lüders, Sebastian Meller, Klaus Jung, Carsten Stephan, Glen Kristiansen
OBJECTIVE: To study the expression of adipophilin (PLIN2), a lipid storage-associated cell protein, in different subtypes of renal cell cancer and to elucidate its prognostic value. MATERIALS AND METHODS: Two-hundred-seventy-five patients with renal cell carcinoma (RCC) were included in this study. Immunohistochemistry with a polyclonal antibody to adipophilin was used on the tissue microarray (formalin-fixed, paraffin-embedded tissue) for detection of adipophilin...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28393205/high-annexin-a5-expression-promotes-tumor-progression-and-poor-prognosis-in-renal-cell-carcinoma
#14
Jingyuan Tang, Zhiqiang Qin, Peng Han, Wei Wang, Chengdi Yang, Zhen Xu, Ran Li, Bianjiang Liu, Chao Qin, Zengjun Wang, Min Tang, Wei Zhang
Annexin A5 has been found to act as an oncogenic protein in a variety of cancers. However, its specific biological role and mechanism in renal cell cancer (RCC) remains unknown. Quantitative Real-time PCR and western blotting were used to evaluate the mRNA and protein expression level of Annexin A5 in human RCC cell lines and tissues. Immunohistochemistry was adopted to measure the Annexin A5 expression in 123 cases of RCC tissues. Survival analysis was performed to explore the association between Annexin A5 expression and the prognosis of RCC...
May 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28353093/pd-l2-a-prognostic-marker-in-chromophobe-renal-cell-carcinoma
#15
Franziska Erlmeier, Wilko Weichert, Michael Autenrieth, Max Wiedemann, Andres Jan Schrader, Arndt Hartmann, Philipp Ivanyi, Sandra Steffens
In the context of cancer immunotherapy, PD-1 as well as PD-L1 has been widely studied in renal cell carcinoma (RCC). PD-1 and PD-L1 play a significant role as prognostic markers in clear cell renal cell carcinoma. In contrast, little is known about PD-L2 expression patterns in RCC, especially in rarer subtypes. The aim of this study was to evaluate the prevalence, distribution and prognostic impact of PD-L2 expression in chromophobe (ch)RCC. Eighty-one patients who underwent renal surgery due to chRCC were retrospectively evaluated...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28349447/overexpression-of-placenta-specific-8-is-associated-with-malignant-progression-and-poor-prognosis-of-clear-cell-renal-cell-carcinoma
#16
Liping Shi, Long Xiao, Baoli Heng, Shijie Mo, Weijun Chen, Zexuan Su
BACKGROUND: Placenta specific 8 (PLAC8) plays an important role in many different cellular processes and human diseases, including multiple types of cancer. However, the functional role of PLAC8 in clear cell renal cell carcinoma (ccRCC) has never been elucidated. METHODS: PLAC8 mRNA expression was investigated in 31 pairs of fresh ccRCC tumor tissues and matched adjacent non-tumor tissues by RT-qPCR and confirmed by analyzing the TCGA KRCC dataset which contains RNA-seq data of 534 ccRCC and 72 solid normal tissues...
July 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28300276/reassessing-the-clinical-spectrum-associated-with-hereditary-leiomyomatosis-and-renal-cell-carcinoma-syndrome-in-french-fh-mutation-carriers
#17
M Muller, S Ferlicot, M Guillaud-Bataille, G Le Teuff, C Genestie, S Deveaux, A Slama, N Poulalhon, B Escudier, L Albiges, N Soufir, M-F Avril, B Gardie, C Saldana, Y Allory, A-P Gimenez-Roqueplo, B Bressac-de Paillerets, S Richard, P R Benusiglio
We addressed uncertainties regarding hereditary leiomyomatosis and renal cell carcinoma (HLRCC) by exploring all French cases, representing the largest series to date. Fumarate hydratase (FH) germline testing was performed with Sanger sequencing and qPCR/MLPA. Enzyme activity was measured when necessary. We carried out whenever possible a pathology review of RCC and S-(2-succino)-cysteine (2SC)/fumarate hydratase immunohistochemistry. We estimated survival using non-parametric Kaplan-Meier. There were 182 cases from 114 families...
March 16, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28296677/rbm10-tfe3-renal-cell-carcinoma-a-potential-diagnostic-pitfall-due-to-cryptic-intrachromosomal-xp11-2-inversion-resulting-in-false-negative-tfe3-fish
#18
MULTICENTER STUDY
Pedram Argani, Lei Zhang, Victor E Reuter, Satish K Tickoo, Cristina R Antonescu
Xp11 translocation renal cell carcinoma (RCC) are defined by chromosome translocations involving the Xp11 breakpoint which results in one of a variety of TFE3 gene fusions. TFE3 break-apart florescence in situ hybridization (FISH) assays are generally preferred to TFE3 immunohistochemistry (IHC) as a means of confirming the diagnosis in archival material, as FISH is less sensitive to the variable fixation which can result in false positive or false negative IHC. Prompted by a case report in the cytogenetics literature, we identify 3 cases of Xp11 translocation RCC characterized by a subtle chromosomal inversion involving the short arm of the X chromosome, resulting in an RBM10-TFE3 gene fusion...
May 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28288038/immunohistochemical-characterization-of-fumarate-hydratase-fh-and-succinate-dehydrogenase-sdh-in-cutaneous-leiomyomas-for-detection-of-familial-cancer-syndromes
#19
Cody S Carter, Stephanie L Skala, Arul M Chinnaiyan, Jonathan B McHugh, Javed Siddiqui, Xuhong Cao, Saravana M Dhanasekaran, Douglas R Fullen, Amir Lagstein, May P Chan, Rohit Mehra
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is caused by germline mutations in the FH gene, and is associated with increased incidence of leiomyomas and a potentially aggressive variant of renal cell carcinoma (HLRCC-associated RCC). Absent immunohistochemical expression of fumarate hydratase (FH) has previously been used to diagnose HLRCC-associated RCC, but immunohistochemical staining of leiomyomas is not standard practice. We performed immunohistochemistry (IHC) on whole sections from consecutive cutaneous leiomyomas from our archives to evaluate for both FH and succinate dehydrogenase B expression, in addition to clinicopathologic data collection and review of all hematoxylin and eosin-stained slides for blinded morphologic evaluation of features reported to be seen in HLRCC-associated uterine leiomyomas...
June 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28249616/tumor-to-tumor-metastases-papillary-thyroid-carcinoma-into-a-clear-cell-renal-cell-carcinoma
#20
Jin Soo Andy Song, S Mark Taylor, Jonathan Trites, Matthew H Rigby, Martin Joseph Bullock, Jennifer Merrimen, Ricardo Rendon, Robert D Hart
BACKGROUND: Thyroid metastases to distant sites are uncommon incidents, most often metastasizing to the lungs and bones. Rates of metastasis to the kidney are particularly low, ranging from 2.8-3.8% for papillary and 6-20% for follicular variants of well-differentiated thyroid cancers (WDTCs). In rare instances, tumor-to-tumor metastasis between two true primary neoplasms can occurs. This medical phenomenon has previously occurred as a clear cell renal cell carcinoma (CCRCC) spreading to a WDTC...
March 1, 2017: Journal of Otolaryngology—Head & Neck Surgery
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