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https://www.readbyqxmd.com/read/29332133/fumarate-hydratase-fh-deficiency-in-uterine-leiomyomas-recognition-by-histological-features-versus-blind-immunoscreening
#1
Lisa Siegler, Ramona Erber, Stefanie Burghaus, Tobias Brodkorb, David Wachter, Nafisa Wilkinson, James Bolton, Helen Stringfellow, Florian Haller, Matthias W Beckmann, Arndt Hartmann, Abbas Agaimy
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is a rare autosomal dominant disease caused by germline mutations in the fumarate hydratase (FH) gene. Affected individuals develop cutaneous and uterine leiomyomas and aggressive RCC. To date, only few publications described the frequency and morphology of FH-deficient uterine leiomyomas. We reviewed 22 cases collected over 8 years from routine and consultation files based on distinctive histological features. In addition, we screened 580 consecutive uterine leiomyomas from 484 patients, 23 extra-uterine and 8 uterine leiomyosarcomas, and 6 leiomyomas with bizarre nuclei for FH loss using immunohistochemistry (IHC) on tissue microarrays (TMAs)...
January 13, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29291011/transferrin-receptor-1-upregulation-in-primary-tumor-and-downregulation-in-benign-kidney-is-associated-with-progression-and-mortality-in-renal-cell-carcinoma-patients
#2
Christopher J Greene, Kristopher Attwood, Nitika J Sharma, Kenneth W Gross, Gary J Smith, Bo Xu, Eric C Kauffman
The central dysregulated pathway of clear cell (cc) renal cell carcinoma (RCC), the von Hippel Lindau/hypoxia inducible factor-α axis, is a key regulator of intracellular iron levels, however the role of iron uptake in human RCC tumorigenesis and progression remains unknown. We conducted a thorough, large-scale investigation of the expression and prognostic significance of the primary iron uptake protein, transferrin receptor 1 (TfR1/CD71/TFRC), in RCC patients. TfR1 immunohistochemistry was performed in over 1500 cores from 574 renal cell tumor patient tissues (primary tumors, matched benign kidneys, metastases) and non-neoplastic tissues from 36 different body sites...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29286924/expression-of-cd105-cancer-stem-cell-marker-in-three-subtypes-of-renal-cell-carcinoma
#3
Leili Saeednejad Zanjani, Zahra Madjd, Maryam Abolhasani, Ahmad Shariftabrizi, Arezoo Rasti, Mojgan Asgari
BACKGROUND: CD105 is recently described as a cancer stem cell (CSC) marker. OBJECTIVE: The present study was aimed to investigate the expression and prognostic significance of the CSC marker CD105 in different histological subtypes of renal cell carcinoma (RCC). METHODS: Expression of CD105 was evaluated using immunohistochemistry in RCC samples on tissue microarrays including clear cell RCCs (ccRCCs), papillary, and chromophobe RCCs. The association between CD105 expression and clinicopathological features as well as survival outcomes was determined...
December 20, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29243496/increased-expression-of-cd44-is-associated-with-more-aggressive-behavior-in-clear-cell-renal-cell-carcinoma
#4
Leili Saeednejad Zanjani, Zahra Madjd, Maryam Abolhasani, Arezoo Rasti, Oystein Fodstad, Yvonne Andersson, Mojgan Asgari
AIM: Although CD44 has been suggested as a prognostic marker in renal cell carcinoma (RCC), the prognostic significance of this marker in three main subtypes of RCC is still unclear. Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. METHODOLOGY/RESULTS: CD44 expression was evaluated in 206 well-defined renal tumor samples using immunohistochemistry on tissue microarrays...
December 15, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29228653/overexpression-of-capn2-promotes-cell-metastasis-and-proliferation-via-akt-mtor-signaling-in-renal-cell-carcinoma
#5
Chenkui Miao, Chao Liang, Ye Tian, Aiming Xu, Jundong Zhu, Kai Zhao, Jianzhong Zhang, Yibo Hua, Shouyong Liu, Huiyu Dong, Chao Zhang, Shifeng Su, Pu Li, Chao Qin, Zengjun Wang
The calpain 2 (CAPN2) is upregulated in various malignant carcinomas. Previous studies have reported that CAPN2 functioned as an oncogenic factor in human cancers. However, its clinical role and potential effects on cell metastasis and proliferation in renal cell carcinoma (RCC) remain unknown. In this study, we evaluated the mRNA and protein levels of CAPN2 in human RCC specimens, matched normal specimens, and RCC cell lines using quantitative Real-time PCR (RT-PCR) and western blot. Immunohistochemistry of 74 RCC tissues in a tissue microarrays (TMAs) and normal kidney tissues were performed...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221190/the-m6a-methyltransferase-mettl3-acting-as-a-tumor-suppressor-in-renal-cell-carcinoma
#6
Xiao Li, Jingyuan Tang, Wen Huang, Feng Wang, Pu Li, Chao Qin, Zhiqiang Qin, Qing Zou, Jifu Wei, Lixin Hua, Haiwei Yang, Zengjun Wang
We aimed to study the role of METTL3 in renal cell carcinoma (RCC) carcinogenesis and development. Immunohistochemistry was performed in clinical tissue microarray. Expression level of METTL3 in RCC tissues and cell lines was evaluated by quantitative real-time PCR (qRT-PCR) and western blot. Then, the effects of METTL3 on proliferation, migration, invasion and cell cycle were studied in RCC cells. Additionally, in vivo study was carried out in nude mice. Negative METTL3 expression was associated with larger tumor size (P=0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212269/low-neighbor-of-brca1-gene-expression-predicts-poor-clinical-outcome-and-resistance-of-sunitinib-in-clear-cell-renal-cell-carcinoma
#7
Wen Xiao, Zhiyong Xiong, Changfei Yuan, Lin Bao, Di Liu, Xiong Yang, Wencheng Li, Junwei Tong, Yan Qu, Lei Liu, Haibing Xiao, Hongmei Yang, Xiaoping Zhang, Ke Chen
Objective: To study the expression of Neighbor of Brca1 gene (NBR1) in clear cell renal cell carcinoma (ccRCC), renal cancer cells and the chemoresistance cells and to elucidate its clinical prognostic and chemoresistance value. Materials and Methods: We screened the NBR1 mRNA in ccRCC from The Cancer Genome Atlas (TCGA) database and examined expression levels of NBR1 mRNA in 48 cases of ccRCC tissues, renal cancer cell lines and chemoresistance cells by qRT-PCR...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209798/-two-synchronous-malignancies-in-a%C3%A2-single-nephrectomy-specimen
#8
J Hrudka, V Eis, J Šach, P Klézl, S Schilling, D Bandke
We report a case of a 65-year-old man examined for hematuria and neurologic symptoms. Radiologically a tumour of the kidney was suspected, with metastatic involvement of the brain and both lungs. The urologists then performed a cytoreductive nephrectomy.In histopathological examination of the nephrectomy specimen a clear cell renal cell carcinoma (clear cell RCC) was found. However, an additional focus of a high-grade adenocarcinoma was discovered that turned out to be a metastasis of a poor differentiated lung adenocarcinoma...
December 5, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29204790/cytoplasmic-expression-of-twist1-an-emt-related-transcription-factor-is-associated-with-higher-grades-renal-cell-carcinomas-and-worse-progression-free-survival-in-clear-cell-renal-cell-carcinoma
#9
Arezoo Rasti, Zahra Madjd, Maryam Abolhasani, Mitra Mehrazma, Leila Janani, Leili Saeednejad Zanjani, Mojgan Asgari
Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis. This study aimed to evaluate the expression patterns and clinical significance of Twist1 in renal cell carcinoma (RCC). The cytoplasmic and nuclear expression of Twist1 were examined in 252 well-defined renal tumor tissues, including 173 (68.7%) clear cell renal cell carcinomas (ccRCC), 45 (17...
December 4, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29187877/overexpression-of-ckap4-is-associated-with-poor-prognosis-in-clear-cell-renal-cell-carcinoma-and-functions-via-cyclin-b-signaling
#10
Chen-Min Sun, Jiang Geng, Yang Yan, Xudong Yao, Min Liu
Aim: We aimed to study the role of CKAP4 in clear cell renal cell carcinoma (ccRCC), which is not reported previously. Method: In silico exploration and validation using immunohistochemistry in ccRCC samples were used to identify the impact of CKAP4 expression on clinicopathological parameters. In vitro and in vivo studies were carried out to recapitulate the role of CKAP4 in ccRCC cell lines and animal models. Results: Overexpression of CKAP4 occurred in 5% of ccRCC patients, who had significantly worsened prognosis...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29187872/tumoral-anxa1-is-a-predictive-marker-for-sunitinib-treatment-of-renal-cancer-patients
#11
Marjut Niinivirta, Gunilla Enblad, Per-Henrik Edqvist, Fredrik Pontén, Anca Dragomir, Gustav J Ullenhag
Background and aims: There is no established predictive marker for the treatment of renal cancer. Metastatic renal cell carcinoma (mRCC) patients are often treated with sunitinib, a tyrosine kinase inhibitor. Sunitinibs anti-cancer effect is at least partly mediated through interfering with angiogenesis. Our aim with the current study was to assess annexin A1 (ANXA1), which stimulates angiogenesis, as a predictive marker for sunitinib therapy in mRCC patients. Since previous studies have indicated a predictive potential for cubilin, we also investigated the predictivity of ANXA1 combined with cubilin...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29180251/renal-cell-carcinoma-with-angioleiomyoma-like-stroma-and-clear-cell-papillary-renal-cell-carcinoma-exploring-sdhb-protein-immunohistochemistry-and-the-relationship-to-tuberous-sclerosis-complex
#12
Sean R Williamson, Jason L Hornick, John N Eble, Nilesh S Gupta, Craig G Rogers, Lawrence True, David J Grignon, Liang Cheng
Renal cell carcinoma (RCC) with angioleiomyoma-like stroma appears to be molecularly distinct from clear cell RCC; however, its relationship to clear cell papillary RCC remains debated. Recent studies have found that similar tumors sometimes occur in patients with tuberous sclerosis complex (TSC), of which one study found unexpectedly negative succinate dehydrogenase (SDH) B immunostaining. We evaluated immunohistochemistry for SDHB in 12 apparently sporadic RCCs with angioleiomyoma-like stroma and correlated with clinical information for stigmata of TSC...
November 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29166326/111in-dtpa-octreotide-spect-octreoscan-uptake-in-metastatic-renal-cell-carcinoma-to-the-pancreas
#13
Kenneth Chan, Tu Vinh Luong, Shaunak Navalkissoor
We report a case of late presentation of metastatic renal cell carcinoma (RCC) demonstrating intense In-DTPA-octreotide uptake in pancreas without recurrence at the primary site. Immunohistochemistry study revealed somatostatin receptor subtype 2 of metastatic RCC preferentially expressed on tumor endothelial cells. The typical hypervascular features of RCC with intense homogeneous contrast enhancement in the arterial phase on CT should raise the possibility of metastatic RCC. This case illustrates that RCC can demonstrate high octreotide uptake in abdominal metastases...
November 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29154986/gv1001-induces-apoptosis-by-reducing-angiogenesis-in-rcc-cells-both-in-vitro-and-in-vivo
#14
Ga Eun Kim, Ae Ryang Jung, Mee Young Kim, Joseph Bada Lee, Ji Houn Im, Kyu Won Lee, Yong Hyun Park, Ji Youl Lee
Objective To investigate the anti-cancer effects of GV1001 and its biological mechanism of action in renal cell carcinoma (RCC). Methods The effects of GV1001 on cell survival and apoptosis in RCC cells were examined in vitro using cell viability assay, fluorescence-activated cell sorting (FACS), and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. To evaluate the effect of GV1001 on migration, invasion and angiogenesis, we used wound healing, invasion, endothelial cell tube formation assay and western blot analysis...
November 15, 2017: Urology
https://www.readbyqxmd.com/read/29133143/pathologic-and-clinical-characteristics-of-early-onset-renal-cell-carcinoma
#15
Tyler Clemmensen, Andres Matoso, Tiffany Graham, Win Shun Lai, Soroush Rais-Bahrami, Jennifer Gordetsky
The majority of RCCs occur within the 7th decade of life, uncommonly arising in adults ≤46years. We reviewed the clinicopathologic features of early-onset renal cell carcinoma (RCC) and evaluated the role of immunohistochemistry (IHC) in potentially identifying diagnoses of newly recognized RCC subtypes that may have been previously misclassified. A retrospective review was performed from 2011-2016 for cases of RCC. Early-onset RCC was defined as ≤46years of age. Clinicopathologic findings and hematoxylin and eosin (H&E) slides were reviewed on early-onset RCC patients...
November 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/29118224/exceptional-response-to-temsirolimus-in-a-metastatic-clear-cell-renal-cell-carcinoma-with-an-early-novel-mtor-activating-mutation
#16
Juan Francisco Rodríguez-Moreno, María Apellaniz-Ruiz, Juan María Roldan-Romero, Ignacio Durán, Luis Beltrán, Cristina Montero-Conde, Alberto Cascón, Mercedes Robledo, Jesus García-Donas, Cristina Rodríguez-Antona
mTOR pathway inhibitors are important drugs for the treatment of advanced renal cell carcinoma (RCC). However, no valid predictive markers have been identified to guide treatment selection and identify patients who are sensitive to these drugs. Mutations activating the mTOR pathway have been suggested to predict response; however, their predictive value is still unclear. Here, we present the genomic and functional characterization of a patient with metastatic clear cell RCC (ccRCC) who experienced a partial response to temsirolimus after a poor response to 2 previous lines of treatment...
November 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29108248/prognostic-relevance-of-androgen-receptor-expression-in-renal-cell-carcinomas
#17
Sebastian Foersch, Mario Schindeldecker, Martina Keith, Katrin E Tagscherer, Aurélie Fernandez, Philipp J Stenzel, Sascha Pahernik, Markus Hohenfellner, Peter Schirmacher, Wilfried Roth, Stephan Macher-Goeppinger
Background: Despite rapid discoveries in molecular biology of renal cell carcinoma (RCC) and advances in systemic targeted therapies, development of new diagnostic and therapeutic strategies is urgently needed. The androgen receptor (AR) has been shown to hold prognostic and predicitve value in several malignancies. Here, we studied a possible association between AR expression and prognosis in patients with RCCs. Results: Low AR expression levels were associated with occurrence of distant metastasis and higher tumor stage in papillary and clear-cell RCCs...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104112/unclassified-hemangioma-like-renal-cell-carcinoma-a-potential-diagnostic-pitfall
#18
Kanika Taneja, Sohrab Arora, Craig G Rogers, Nilesh S Gupta, Liang Cheng, Sean R Williamson
Recently, rare renal cell carcinomas (RCC) have been reported to closely mimic hemangioma; however, these have been largely recognizable as clear cell RCC. Conversely, true hemangiomas of the kidney are also increasingly recognized. We report a 62-year-old woman who underwent partial nephrectomy for a hemangioma-like RCC without appreciable clear cell morphology. Immunohistochemistry revealed luminal structures that stained positively for cytokeratin (CK), CK7, carbonic anhydrase IX, PAX8, and high molecular weight keratin (HMWK), admixed with a CD34, CD31, and ERG-positive complex network of vessels...
November 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/29099381/-adenoma-metanephric-report-of-2-cases-and-bibliographic-review
#19
Enrique Rodríguez-Zarco, Ana Vallejo-Benítez, Francisco Javier Farfán-López, Ángel Vilches-Arenas, Sofía Pereira-Gallardo, Francisco Javier Vázquez-Ramírez
OBJECTIVE: Two cases of metanephric adenoma are presented, a rare benign renal tumor, and a literature review is done under the current WHO classification (2016). METHODS: Standard histopathological study was performed with hematoxylin-eosin and immunohistochemistry to analyze the expression of WT, Vimentin, Racemase, CK7, CD10 and RCC. RESULTS: Neoplasms of 3 and 4.5 cm, histologically, exhibiting tubulopapillary architecture. There was no evidence of significant nuclear atypia and mitotic figures...
November 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29079986/percutaneous-image-guided-core-biopsy-of-solid-renal-masses-analysis-of-safety-efficacy-pathologic-interpretation-and-clinical-significance
#20
Nisha Alle, Nelly Tan, Julie Huss, Jiatoi Huang, Allan Pantuck, Steven S Raman
PURPOSE: To determine the efficacy, safety and clinical utility of CT and US-guided percutaneous renal mass biopsy. MATERIALS AND METHODS: A retrospective IRB-approved, HIPAA-compliant study of a cohort of 183 consecutive patients who underwent percutaneous, CT or US-guided renal mass biopsy (RMB) from March 2002 through December 2012 was performed. RMB was performed in 183 consecutive patients for suspected solid renal mass of whom 14/183 (7.7%) were excluded because biopsies were performed at an outside institution, medical records were incomplete, or lesions were poorly visualized...
October 27, 2017: Abdominal Radiology
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