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https://www.readbyqxmd.com/read/28593993/myc-activation-cooperates-with-vhl-and-ink4a-arf-loss-to-induce-clear-cell-renal-cell-carcinoma
#1
Sean T Bailey, Aleisha M Smith, Jordan Kardos, Sara E Wobker, Harper L Wilson, Bhavani Krishnan, Ryoichi Saito, Hyo Jin Lee, Jing Zhang, Samuel C Eaton, Lindsay A Williams, Ujjawal Manocha, Dorien J Peters, Xinchao Pan, Thomas J Carroll, Dean W Felsher, Vonn Walter, Qing Zhang, Joel S Parker, Jen Jen Yeh, Richard A Moffitt, Janet Y Leung, William Y Kim
Renal carcinoma is a common and aggressive malignancy whose histopathogenesis is incompletely understood and that is largely resistant to cytotoxic chemotherapy. We present two mouse models of kidney cancer that recapitulate the genomic alterations found in human papillary (pRCC) and clear cell RCC (ccRCC), the most common RCC subtypes. MYC activation results in highly penetrant pRCC tumours (MYC), while MYC activation, when combined with Vhl and Cdkn2a (Ink4a/Arf) deletion (VIM), produce kidney tumours that approximate human ccRCC...
June 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28533051/features-of-ipsilateral-renal-recurrences-after-partial-nephrectomy-a-proposal-of-a-pathogenetic-classification
#2
Alessandro Antonelli, Maria Furlan, Regina Tardanico, Simona Fisogni, Mario Sodano, Francesca Carobbio, Sandra Belotti, Alberto Cozzoli, Tiziano Zanotelli, Claudio Simeone
BACKGROUND: Poor data are reported on the pathogenesis of ipsilateral relapse (IR) after partial nephrectomy (PN). The objective of this study was to investigate features of IR after PN with the intention to propose a pathogenetic classification. MATERIALS AND METHODS: Retrospective consultation of an institutional database that stores the data of 683 patients submitted to PN since 1993. The clinical, radiological, and follow-up data of the cases submitted to salvage nephrectomy due to an IR were analyzed...
April 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28416107/characteristics-of-the-peritumoral-pseudocapsule-vary-predictably-with-histologic-subtype-of-t1-renal-neoplasms-jacob-jm-williamson-sr-gondim-dd-leese-ja-terry-c-grignon-dj-boris-rs-urology-november-2015-86-5-956-961
#3
Oleksandr N Kryvenko
OBJECTIVE: To determine characteristics of the peritumoral pseudocapsule (PC) between renal tumor subtypes. METHODS: The peritumoral PCs of 160 pT1 renal tumors were examined, including 60 clear cell renal cell carcinomas (RCCs), 50 papillary RCCs, 25 chromophobe RCCs, and 25 oncocytoma. Pathologic features (presence or absence of PC, mean thickness, continuity, and invasion by tumor) were analyzed. PC thickness was measured using an ocular micrometer to the nearest 1/10mm...
June 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28351779/prognostic-factors-for-overall-survival-after-lung-metastasectomy-in-renal-cell-cancer-patients-a-systematic-review-and-meta-analysis
#4
REVIEW
Yongsheng Zhao, Jian Li, Chuan Li, Jun Fan, Lunxu Liu
BACKGROUND: Pulmonary metastasis of Renal cell carcinomas (RCC) is usually considered as a systemic disease. However, some studies revealed potential survival benefits of pulmonary metastasectomies for such patients. The aim of this study was to conduct a systematic review and meta-analysis to assess the prognostic factors for pulmonary metastasectomy of RCC patients. METHODS: An electronic search in MEDLINE, EMBASE, CENTRAL and Chinese BioMedical Literature Database (CBM) were conducted to identify eligible studies...
March 27, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28321372/treatment-outcomes-of-rathke-s-cleft-cysts-managed-with-marsupialization
#5
Edward C Kuan, Frederick Yoo, Jennifer Chyu, Marvin Bergsneider, Marilene B Wang
Objectives Rathke's cleft cysts (RCC) are benign cystic lesions of the sella resulting from incomplete obliteration of Rathke's cleft. Symptomatic lesions often require surgical decompression, which is often amenable to a transnasal, transsphenoidal (TNTS) approach. We report our experience with marsupialization of RCC and describe a novel technique to promote re-epithelization of the cyst cavity. Design Retrospective review. Setting Tertiary academic medical center. Participants Patients who underwent TNTS for RCC between 2007 and 2015...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28315424/diagnostic-criteria-for-oncocytic-renal-neoplasms-a-survey-of-urologic-pathologists
#6
Sean R Williamson, Ramya Gadde, Kiril Trpkov, Michelle S Hirsch, John R Srigley, Victor E Reuter, Liang Cheng, L Priya Kunju, Ravi Barod, Craig G Rogers, Brett Delahunt, Ondrej Hes, John N Eble, Ming Zhou, Jesse K McKenney, Guido Martignoni, Stewart Fleming, David J Grignon, Holger Moch, Nilesh S Gupta
Renal oncocytoma and chromophobe renal cell carcinoma (RCC) have been long recognized as distinct tumors; however, it remains unknown if uniform diagnostic criteria are used to distinguish these tumor types in practice. A survey was distributed to urologic pathologists regarding oncocytic tumors. Responses were received from 17/26 invitees. Histologically, >1 mitotic figure was regarded as most worrisome (n=10) or incompatible (n=6) with oncocytoma diagnosis. Interpretation of focal nuclear wrinkling, focal perinuclear clearing, and multinucleation depended on extent and did not necessarily exclude oncocytoma if minor...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28188091/a-prospective-multicenter-analysis-of-pseudocapsule-characteristics-do-all-stages-of-renal-cell-carcinoma-have-complete-pseudocapsules
#7
Seok Cho, Jeong Hyeon Lee, Seung Hyun Jeon, Jinsung Park, Sang Hyub Lee, Chul Hwan Kim, Ji-Youn Sung, Joo Heon Kim, Jong Hyun Pyun, Jeong Gu Lee, Je Jong Kim, Jun Cheon, Sung Gu Kang, Seok Ho Kang
OBJECTIVES: To assess the characteristics of pseudocapsule (PC) in localized renal cell carcinoma (RCC) by analyzing the rates of completeness of PC and pseudocapsular invasion and clinical and pathological risk factors of it. MATERIALS AND METHODS: Between February 2013 and September 2015, data were gathered prospectively from 180 consecutive patients who underwent partial nephrectomy or radical nephrectomy at 3 institutions, and 161 were enrolled. Evaluated factors included age and sex; histologic factors such as tumor diameter, stage, tumor subtype, necrosis, and Fuhrman grade; and clinical factors such as RENAL score; and completeness of PC...
June 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28185421/fine-needle-aspiration-findings-of-xp11-translocation-renal-cell-carcinoma-metastatic-to-a-hilar-lymph-node
#8
Reima El Naili, Marlo Nicolas, Amanda Gorena, Maria Luisa C Policarpio-Nicolas
Xp11 translocation renal cell carcinoma (RCC) is a specific type of renal cell carcinoma recently placed under the "MiT family translocation RCC" at the last 2013 ISUP Vancouver classification of renal neoplasia. This tumor contains variable proportions of clear cells and could easily mimic papillary RCC, clear cell type, and clear cell papillary RCC. Given the small number of published cytologic findings of this tumor, it could easily present as a diagnostic pitfall. We describe a case of a 23-year-old man with a history of prior nephrectomy who presented with multiple mediastinal lymphadenopathies on imaging surveillance follow-up...
May 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28116740/determination-of-the-safe-surgical-margin-for-t1b-renal-cell-carcinoma
#9
Kan Zhang, Wen Lian Xie
PURPOSE: To determine the rational surgical margin for pathological T1b renal cell carcinoma (RCC). MATERIALS AND METHODS: This retrospective study included surveys of 60 patients with T1bN0M0 RCC who underwentradical nephrectomy (RN, n = 40) or partial nephrectomy (PN, n = 20) between October 2008 and December2014 at the Sun Yat-sen Memorial Hospital affiliated with Zhongshan University. Specimens were collectedfrom 6 sites at the tumour periphery for RN and PN, and at suspected sites on the tumour surface for PN in addition...
January 18, 2017: Urology Journal
https://www.readbyqxmd.com/read/28061437/keap1-nrf2-pathway-in-kidney-cancer-frequent-methylation-of-keap1-gene-promoter-in-clear-renal-cell-carcinoma
#10
Federico Pio Fabrizio, Manuela Costantini, Massimiliano Copetti, Annamaria la Torre, Angelo Sparaneo, Andrea Fontana, Luana Poeta, Michele Gallucci, Steno Sentinelli, Paolo Graziano, Paola Parente, Vincenzo Pompeo, Laura De Salvo, Giuseppe Simone, Rocco Papalia, Francesco Picardo, Teresa Balsamo, Gerardo Paolo Flammia, Domenico Trombetta, Angela Pantalone, Klaas Kok, Ferronika Paranita, Lucia Anna Muscarella, Vito Michele Fazio
The Keap1/Nrf2 pathway is a master regulator of the cellular redox state through the induction of several antioxidant defence genes implicated in chemotherapeutic drugs resistance of tumor cells. An increasing body of evidence supports a key role for Keap1/Nrf2 pathway in kidney diseases and renal cell carcinoma (RCC), but data concerning the molecular basis and the clinical effect of its deregulation remain incomplete.Here we present a molecular profiling of the KEAP1 and NFE2L2 genes in five different Renal Cell Carcinoma histotypes by analysing 89 tumor/normal paired tissues (clear cell Renal Carcinoma, ccRCCs; Oncocytomas; Papillary Renal Cell Carcinoma Type 1, PRCC1; Papillary Renal Cell Carcinoma Type 2, PRCC2; and Chromophobe Cell Carcinoma)...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/27793960/u-s-food-and-drug-administration-approval-cabozantinib-for-treatment-of-advanced-renal-cell-carcinoma
#11
Harpreet Singh, Michael Brave, Julia A Beaver, Joyce Cheng, Shenghui Tang, Eias Zahalka, Todd R Palmby, Rajesh Venugopal, Pengfei Song, Qi Liu, Chao Liu, Jingyu Yu, Xiao Hong Chen, Xing Wang, Yaning Wang, Paul G Kluetz, Selena R Daniels, Elektra J Papadopoulos, Rajeshwari Sridhara, Amy E McKee, Amna Ibrahim, Geoffrey Kim, Richard Pazdur
On April 25, 2016, the U. S. Food and Drug Administration (FDA) approved cabozantinib (CABOMETYX{trade mark, serif}, Exelixis, Inc.) for the treatment of advanced renal cell carcinoma (RCC) in patients who have received prior anti-angiogenic therapy. The approval was based on data from one randomized, open-label, multicenter study in which RCC patients who had received prior anti-angiogenic therapy were treated with either cabozantinib 60 mg orally once daily (N=330) or everolimus 10 mg orally once daily (N=328)...
October 28, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27562252/renal-cell-carcinoma-with-inferior-vena-cava-involvement-prognostic-effect-of-tumor-thrombus-consistency-on-cancer-specific-survival
#12
MULTICENTER STUDY
Rene Mager, Siamak Daneshmand, Christopher P Evans, Joan Palou, Juan I Martínez-Salamanca, Viraj A Master, James M McKiernan, John A Libertino, Axel Haferkamp, Axel Haferkamp, Umberto Capitanio, Joaquín A Carballido, Venancio Chantada, Thomas Chromecki, Gaetano Ciancio, Siamak Daneshmand, Christopher P Evans, Paolo Gontero, Javier González, Markus Hohenfellner, William C Huang, Theresa M Koppie, John A Libertino, Estefanía Linares Espinós, Adam Lorentz, Juan I Martínez-Salamanca, Viraj A Master, James M McKiernan, Francesco Montorsi, Giacomo Novara, Padraic O'Malley, Sascha Pahernik, Joan Palou, José Luis Pontones Moreno, Raj S Pruthi, Oscar Rodriguez Faba, Paul Russo, Douglas S Scherr, Shahrokh F Shariat, Martin Spahn, Carlo Terrone, Derya Tilki, Dario Vázquez-Martul, Cesar Vera Donoso, Daniel Vergho, Eric M Wallen, Richard Zigeuner
BACKGROUND: Renal cell carcinoma forming a venous tumor thrombus (VTT) in the inferior vena cava (IVC) has a poor prognosis. Recent investigations have been focused on prognostic markers of survival. Thrombus consistency (TC) has been proposed to be of significant value but yet there are conflicting data. The aim of this study is to test the effect of IVC VTT consistency on cancer specific survival (CSS) in a multi-institutional cohort. METHODS: The records of 413 patients collected by the International Renal Cell Carcinoma-Venous Thrombus Consortium were retrospectively analyzed...
November 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27434279/metastatic-urinary-tract-cancers-in-pap-test-cytomorphologic-findings-and-differential-diagnosis
#13
Derek B Allison, Matthew T Olson, Zahra Maleki, Syed Z Ali
Although the cervical Pap test was devised for the detection of primary cervical neoplasia, it can provide additional diagnostic information, and in some cases, be diagnostic for noncervical processes. The diagnosis of metastatic extrauterine cervical cancers on the Pap test is extremely rare; and in most cases, it is the result of an ovarian or fallopian tube primary. Further, urinary tract cancers, including renal and urinary primaries are exceedingly rare. To our knowledge, six surgical cases of metastatic clear cell renal cell carcinoma (RCC) have been described...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27338155/complete-metastasectomy-for-renal-cell-carcinoma-comparison-of-five-solid-organ-sites
#14
COMPARATIVE STUDY
Christopher D Jakubowski, Emily A Vertosick, Brian R Untch, Daniel Sjoberg, Elizabeth Wei, Frank L Palmer, Snehal G Patel, Robert J Downey, Vivian E Strong, Paul Russo
BACKGROUND AND OBJECTIVES: Patients with metastatic RCC can undergo metastasectomy to improve survival time. Our goal was to provide and compare characteristics and oncological outcomes of RCC patients who underwent complete metastasectomy at a single organ site. METHODS: A total of 138 RCC patients were identified as undergoing complete metastasectomy at a single organ site including adrenal, lung, liver, pancreas, or thyroid. Competing risk regression analysis was used to assess RFS and CSS adjusting for several covariates...
September 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27323152/il-16-rs4778889-polymorphism-contribution-to-the-development-of-renal-cell-cancer-in-a-chinese-population
#15
S X Yang, F Chen, J W Zhang, Z Q Sun, B P Chen
IL-16 plays an important role in affect the secretion of tumor-related inflammatory cytokines. We aimed to assess the role of interleukin-16 (IL-16) rs4778889 T/C and rs11556218 T/G polymorphisms in the occurrence of renal cell cancer (RCC). This study is composed of 274 RCC patients and 274 control subjects. Genotyping of polymorphisms was performed using polymerase chain reaction combined with restriction fragment length polymorphism analysis. All statistical analysis was carried out by the SPSS statistical software package, version 16...
June 10, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27074886/surgical-margin-does-not-influence-recurrence-rate-in-pt1-clear-cell-renal-cell-carcinoma-after-partial-nephrectomy-a-multicenter-study
#16
MULTICENTER STUDY
Ho Won Kang, Sang Keun Lee, Won Tae Kim, Seok Joong Yun, Sang-Cheol Lee, Wun-Jae Kim, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Hyeon Hoe Kim, Cheol Kwak, Seok-Soo Byun, Yong-June Kim
PURPOSE: To assess the risk factors of positive surgical margins (PSM) and the influence of margin status on recurrence in pT1 clear cell renal cell carcinoma (RCC) following partial nephrectomy (PN). MATERIALS AND METHODS: Patients (1,831) with pathologically confirmed stage T1 clear cell RCC were retrospectively analyzed following PN at eight institutions in Korea between 1999 and 2011. Demographics, operative data, pathological margin status, and site of recurrence were analyzed...
July 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26863421/organ-preserving-surgical-treatment-of-a-horseshoe-kidney-occupied-by-a-large-renal-cell-carcinoma-with-extensive-venous-invasion-a-case-report
#17
Johannes Linxweiler, Roushanak Shayesteh-Kheslat, Peter Fries, Günther Schneider, Martin Janssen, Carsten H Ohlmann, Michael Stöckle, Stefan Siemer, Matthias Saar
The horseshoe kidney is one of the most common congenital disorders affecting the urogenital system. Following a fusion of the lower kidney poles, which in turn lead to the formation of an isthmus, this anatomical variation is accompanied by other characteristic properties like an incomplete ascension, ventral rotation of the pelvices as well as atypical vascular supply. Even though renal carcinoids and Wilms tumors are more common in horseshoe kidneys, the incidence of renal cell carcinomas seems to be unaffected...
February 11, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/26846902/spinal-metastasectomy-of-renal-cell-carcinoma-a-16-year-single-center-experience-with-a-minimum-3-year-follow-up
#18
Satoshi Kato, Hideki Murakami, Satoru Demura, Koshi Nambu, Yoshiyasu Fujimaki, Katsuhito Yoshioka, Norio Kawahara, Katsuro Tomita, Hiroyuki Tsuchiya
BACKGROUND AND OBJECTIVES: Metastasectomy of spinal lesions from renal cell carcinoma (RCC) is a promising strategy. However, its clinical outcome after spinal metastasectomy is unknown owing to the difficulty of curative surgical resection. This is the first study to examine the survival rates of patients who underwent metastasectomy of solitary spinal metastases from RCC. METHODS: A retrospective cohort study of 36 consecutive patients with RCC who underwent nephrectomy and complete removal of solitary spinal lesions between 1995 and 2010 at our institution...
April 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26776076/genome-wide-uniparental-disomy-and-copy-number-variations-in-renal-cell-carcinomas-associated-with-birt-hogg-dub%C3%A3-syndrome
#19
Yasuhiro Iribe, Masahiro Yao, Reiko Tanaka, Naoto Kuroda, Yoji Nagashima, Yukio Nakatani, Mitsuko Furuya
Birt-Hogg-Dubé syndrome is an inherited disorder caused by germline mutations of the folliculin gene (FLCN). The affected patients are prone to developing renal cell carcinomas (RCCs). Most mutant FLCN-associated RCCs (mFLCN-RCCs) are histologically chromophobe RCCs and hybrid oncocytic/chromophobe tumors. It is incompletely understood whether mFLCN-RCCs have different chromosomal abnormalities compared with their sporadic histological counterparts. Herein, we describe somatic mutations of FLCN and DNA-copy number abnormalities using a high-density, whole-genome, single-nucleotide polymorphism array...
February 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/26531112/impact-of-fellowship-training-on-robotic-assisted-laparoscopic-partial-nephrectomy-benchmarking-perioperative-safety-and-outcomes
#20
Abby S Taylor, Bruce Lee, Bhupendra Rawal, David D Thiel
To provide perioperative benchmark data for surgeons entering practice from formal robotic training and performing robotic-assisted laparoscopic partial nephrectomy (RAPN). Perioperative outcomes of the first 100 RAPN from a surgeon entering into practice directly from robotic fellowship training were analyzed. Postoperative complications were categorized by Clavien-Dindo grade. Surgical "trifecta scores" and Margin, Ischemia, and Complication (MIC) scoring were utilized to assess surgical outcomes. Statistical analyses were performed using SAS (version 9...
June 2015: Journal of Robotic Surgery
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