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Rcc inc

Rene Mager, Siamak Daneshmand, Christopher P Evans, Joan Palou, Juan I Martínez-Salamanca, Viraj A Master, James M McKiernan, John A Libertino, Axel Haferkamp, Axel Haferkamp, Umberto Capitanio, Joaquín A Carballido, Venancio Chantada, Thomas Chromecki, Gaetano Ciancio, Siamak Daneshmand, Christopher P Evans, Paolo Gontero, Javier González, Markus Hohenfellner, William C Huang, Theresa M Koppie, John A Libertino, Estefanía Linares Espinós, Adam Lorentz, Juan I Martínez-Salamanca, Viraj A Master, James M McKiernan, Francesco Montorsi, Giacomo Novara, Padraic O'Malley, Sascha Pahernik, Joan Palou, José Luis Pontones Moreno, Raj S Pruthi, Oscar Rodriguez Faba, Paul Russo, Douglas S Scherr, Shahrokh F Shariat, Martin Spahn, Carlo Terrone, Derya Tilki, Dario Vázquez-Martul, Cesar Vera Donoso, Daniel Vergho, Eric M Wallen, Richard Zigeuner
BACKGROUND: Renal cell carcinoma forming a venous tumor thrombus (VTT) in the inferior vena cava (IVC) has a poor prognosis. Recent investigations have been focused on prognostic markers of survival. Thrombus consistency (TC) has been proposed to be of significant value but yet there are conflicting data. The aim of this study is to test the effect of IVC VTT consistency on cancer specific survival (CSS) in a multi-institutional cohort. METHODS: The records of 413 patients collected by the International Renal Cell Carcinoma-Venous Thrombus Consortium were retrospectively analyzed...
August 26, 2016: Journal of Surgical Oncology
Derek B Allison, Matthew T Olson, Zahra Maleki, Syed Z Ali
Although the cervical Pap test was devised for the detection of primary cervical neoplasia, it can provide additional diagnostic information, and in some cases, be diagnostic for noncervical processes. The diagnosis of metastatic extrauterine cervical cancers on the Pap test is extremely rare; and in most cases, it is the result of an ovarian or fallopian tube primary. Further, urinary tract cancers, including renal and urinary primaries are exceedingly rare. To our knowledge, six surgical cases of metastatic clear cell renal cell carcinoma (RCC) have been described...
July 19, 2016: Diagnostic Cytopathology
Christopher D Jakubowski, Emily A Vertosick, Brian R Untch, Daniel Sjoberg, Elizabeth Wei, Frank L Palmer, Snehal G Patel, Robert J Downey, Vivian E Strong, Paul Russo
BACKGROUND AND OBJECTIVES: Patients with metastatic RCC can undergo metastasectomy to improve survival time. Our goal was to provide and compare characteristics and oncological outcomes of RCC patients who underwent complete metastasectomy at a single organ site. METHODS: A total of 138 RCC patients were identified as undergoing complete metastasectomy at a single organ site including adrenal, lung, liver, pancreas, or thyroid. Competing risk regression analysis was used to assess RFS and CSS adjusting for several covariates...
September 2016: Journal of Surgical Oncology
S X Yang, F Chen, J W Zhang, Z Q Sun, B P Chen
IL-16 plays an important role in affect the secretion of tumor-related inflammatory cytokines. We aimed to assess the role of interleukin-16 (IL-16) rs4778889 T/C and rs11556218 T/G polymorphisms in the occurrence of renal cell cancer (RCC). This study is composed of 274 RCC patients and 274 control subjects. Genotyping of polymorphisms was performed using polymerase chain reaction combined with restriction fragment length polymorphism analysis. All statistical analysis was carried out by the SPSS statistical software package, version 16...
2016: Genetics and Molecular Research: GMR
Ho Won Kang, Sang Keun Lee, Won Tae Kim, Seok Joong Yun, Sang-Cheol Lee, Wun-Jae Kim, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Hyeon Hoe Kim, Cheol Kwak, Seok-Soo Byun, Yong-June Kim
PURPOSE: To assess the risk factors of positive surgical margins (PSM) and the influence of margin status on recurrence in pT1 clear cell renal cell carcinoma (RCC) following partial nephrectomy (PN). MATERIALS AND METHODS: Patients (1,831) with pathologically confirmed stage T1 clear cell RCC were retrospectively analyzed following PN at eight institutions in Korea between 1999 and 2011. Demographics, operative data, pathological margin status, and site of recurrence were analyzed...
July 2016: Journal of Surgical Oncology
Johannes Linxweiler, Roushanak Shayesteh-Kheslat, Peter Fries, Günther Schneider, Martin Janssen, Carsten H Ohlmann, Michael Stöckle, Stefan Siemer, Matthias Saar
The horseshoe kidney is one of the most common congenital disorders affecting the urogenital system. Following a fusion of the lower kidney poles, which in turn lead to the formation of an isthmus, this anatomical variation is accompanied by other characteristic properties like an incomplete ascension, ventral rotation of the pelvices as well as atypical vascular supply. Even though renal carcinoids and Wilms tumors are more common in horseshoe kidneys, the incidence of renal cell carcinomas seems to be unaffected...
February 11, 2016: Urologia Internationalis
Satoshi Kato, Hideki Murakami, Satoru Demura, Koshi Nambu, Yoshiyasu Fujimaki, Katsuhito Yoshioka, Norio Kawahara, Katsuro Tomita, Hiroyuki Tsuchiya
BACKGROUND AND OBJECTIVES: Metastasectomy of spinal lesions from renal cell carcinoma (RCC) is a promising strategy. However, its clinical outcome after spinal metastasectomy is unknown owing to the difficulty of curative surgical resection. This is the first study to examine the survival rates of patients who underwent metastasectomy of solitary spinal metastases from RCC. METHODS: A retrospective cohort study of 36 consecutive patients with RCC who underwent nephrectomy and complete removal of solitary spinal lesions between 1995 and 2010 at our institution...
April 2016: Journal of Surgical Oncology
Yasuhiro Iribe, Masahiro Yao, Reiko Tanaka, Naoto Kuroda, Yoji Nagashima, Yukio Nakatani, Mitsuko Furuya
Birt-Hogg-Dubé syndrome is an inherited disorder caused by germline mutations of the folliculin gene (FLCN). The affected patients are prone to developing renal cell carcinomas (RCCs). Most mutant FLCN-associated RCCs (mFLCN-RCCs) are histologically chromophobe RCCs and hybrid oncocytic/chromophobe tumors. It is incompletely understood whether mFLCN-RCCs have different chromosomal abnormalities compared with their sporadic histological counterparts. Herein, we describe somatic mutations of FLCN and DNA-copy number abnormalities using a high-density, whole-genome, single-nucleotide polymorphism array...
February 2016: American Journal of Pathology
Abby S Taylor, Bruce Lee, Bhupendra Rawal, David D Thiel
To provide perioperative benchmark data for surgeons entering practice from formal robotic training and performing robotic-assisted laparoscopic partial nephrectomy (RAPN). Perioperative outcomes of the first 100 RAPN from a surgeon entering into practice directly from robotic fellowship training were analyzed. Postoperative complications were categorized by Clavien-Dindo grade. Surgical "trifecta scores" and Margin, Ischemia, and Complication (MIC) scoring were utilized to assess surgical outcomes. Statistical analyses were performed using SAS (version 9...
June 2015: Journal of Robotic Surgery
Domenico Solari, Luigi Maria Cavallo, Teresa Somma, Carmela Chiaramonte, Felice Esposito, Marialaura Del Basso De Caro, Paolo Cappabianca
OBJECTIVE: Rathke's cleft cysts (RCCs) are quite uncommon sellar lesions that can extend or even arise in the suprasellar area. The purpose of this study is to evaluate the effectiveness of both standard and extended endoscopic endonasal approaches in the management of different located RCCs. METHODS: We retrospectively analyzed a series of 29 patients (9 males, 20 females) complaining of a RCC, who underwent a standard or an extended endoscopic transsphenoidal approach at the Division of Neurosurgery, Department of Neurosciences and Reproductive and Odontostomatological Sciences, of the Università degli Studi di Napoli "Federico II"...
2015: PloS One
Justin Rivard, Xanthoula Kostaras, Melissa Shea-Budgell, Laura Chin-Lenn, May Lynn Quan, J Gregory McKinnon
BACKGROUND: Regionalization of care to specialized centers has improved outcomes for several cancer types. We sought to determine if treatment in a regional cancer center (RCC) impacts guideline adherence and outcomes for patients with melanoma. METHODS: In Alberta, Canada, 561 patients with stage I-IIIC primary melanoma were diagnosed between January 2009 and December 2010. The electronic health record was used to capture demographic and pathologic data. Provincial guidelines for sentinel lymph node biopsy (SLNB) and wide local excision (WLE) are based on recommendations of several pre-existing guidelines including the National Comprehensive Cancer Network...
August 2015: Journal of Surgical Oncology
Reagan L Maniar, Peter Sytnik, Debrah A Wirtzfeld, David J Hochman, Andrew M McKay, Benson Yip, Pamela C Hebbard, Jason Park
BACKGROUND: Implementation of best practices surgical checklists improves patient safety and outcomes. However, documenting performance of these practices can be challenging. The American Society of Colon and Rectal Surgeons developed a Best Practices for Rectal Cancer Checklist (RCC) to standardize and improve the quality of rectal cancer surgery. This study compared the degree to which synoptic (SR) and narrative (NR) operative reports document RCC items. METHODS: Two reviewers independently reviewed a cohort of prospectively collected SR for rectal cancer surgery and a case-matched historical cohort of NR...
October 2015: Journal of Surgical Oncology
Jie Lin, Elizabeth Butts, Paul D Rockswold, Craig D Shriver, Kangmin Zhu
BACKGROUND: Information on ethnicity is important for health disparity research and health service planning. However, information on ethnicity is often incomplete in large routine databases such as cancer registries. This study aimed to compare survival status and other characteristics between cancer patients with and without information on Hispanic ethnicity in cancer registry data. METHODS: The study included 2,426 patients with clear cell renal cell carcinoma (RCC) diagnosed between 1988 and 2004 and identified from the US Department of Defense (DoD)'s Automated Central Tumor Registry (ACTUR) database...
2015: Journal of Registry Management
Jennifer D Cohen, Matthew Labenski, Nicholas J Mastrandrea, Ryan D Canatsey, Terrence J Monks, Serrine S Lau
Increased activity of B-Raf has been identified in approximately 7% of human cancers. Treatment of Eker rats (Tsc-2(EK/+) ), bearing a mutation in one allele of the tuberous sclerosis-2 (Tsc-2) gene, with the nephrocarcinogen 2,3,5-tris-(glutathion-S-yl) hydroquinone (TGHQ) results in loss of the wild-type allele of Tsc-2 in renal preneoplastic lesions and tumors. These tumors have increased protein expression of B-Raf, C-Raf (Raf-1), and increased expression and activity of ERK kinase. Similar changes are observed in Raf kinases following TGHQ-mediated transformation of primary renal epithelial cells derived from Tsc-2(EK/+) rats (QTRRE cells), cells that are also null for tuberin...
August 2016: Molecular Carcinogenesis
Sandy Giuliano, Yann Cormerais, Maeva Dufies, Renaud Grépin, Pascal Colosetti, Amine Belaid, Julien Parola, Anthony Martin, Sandra Lacas-Gervais, Nathalie M Mazure, Rachid Benhida, Patrick Auberger, Baharia Mograbi, Gilles Pagès
Metastatic renal cell carcinomas (mRCC) are highly vascularized tumors that are a paradigm for the treatment with antiangiogenesis drugs targeting the vascular endothelial growth factor (VEGF) pathway. The available drugs increase the time to progression but are not curative and the patients eventually relapse. In this study we have focused our attention on the molecular mechanisms leading to resistance to sunitinib, the first line treatment of mRCC. Because of the anarchic vascularization of tumors the core of mRCC tumors receives only suboptimal concentrations of the drug...
2015: Autophagy
Michela de Martino, Christopher Taus, Ilaria Lucca, Sebastian L Hofbauer, Andrea Haitel, Shahrokh F Shariat, Tobias Klatte
Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the human telomerase and plays a key role in telomere restitution and gene regulation. Evidence suggests that hTERT is linked with the risk and progression of several malignancies, but there are no comprehensive data in renal cell carcinoma (RCC). In this case-control study, we assessed seven polymorphic hTERT gene variants (MNS16A, rs2736100, rs2736098, rs7726159, rs2853677, rs13172201, and rs10069690), hTERT serum levels, and the telomere length of 663 individuals, including 243 with clear cell RCC and 420 age- and gender-matched healthy controls...
October 2016: Molecular Carcinogenesis
Rema Rao, David Molina, Allison M Halligan, Behzad Vakil, Susan A Alperstein, Rana S Hoda
Women ≥30 years of age with negative (-) Pap tests and positive (+) HPV co-test results have a higher prevalence and cumulative risk of developing high-grade cervical intraepithelial neoplasia (CIN 2+). Thus, the current management in these women is to repeat co-test in 12 months or immediate reflex genotyping for HPV16 or HPV 16/18. If genotyping is not an option, timely quality assurance (QA) rescreen of such Pap tests may be a valuable alternative. All ThinPrep Pap tests (TPPT) interpreted as negative for intra epithelial lesion (NILM) or NILM with reactive cellular changes (NILM/RCC) and a (+) high-risk HPV [Hybrid Capture 2 (HC2), Qiagen, Hilden, Germany] co-test result over a 45-month period (10/2009-06/2013) underwent monthly QA review...
September 2015: Diagnostic Cytopathology
Maryam Abolhasani, Sareh Salarinejad, Mojgan Asgari
BACKGROUND: Relatively little is known with certainty about the status and role of p53 or MDM2 in predicting prognosis and survival of renal cell carcinoma. The present study aimed to determine the value of P53 and MDM2 over-expression, alone and simultaneously, to predict five-year survival of patients with kidney cancer in Iran. MATERIALS AND METHODS: Patients with kidney cancer referred to Hasheminejad Kidney Center between 2007 and 2009, underwent radical nephrectomy and had pathology reports of clear cell, papillary or chromophobe renal cell carcinoma were included in our cohort study...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Joseph M Jacob, Sean R Williamson, Dibson D Gondim, Joshua A Leese, Colin Terry, David J Grignon, Ronald S Boris
OBJECTIVE: To determine characteristics of the peritumoral pseudocapsule (PC) between renal tumor subtypes. METHODS: The peritumoral PCs of 160 pT1 renal tumors were examined, including 60 clear cell renal cell carcinomas (RCCs), 50 papillary RCCs, 25 chromophobe RCCs, and 25 oncocytoma. Pathologic features (presence or absence of PC, mean thickness, continuity, and invasion by tumor) were analyzed. PC thickness was measured using an ocular micrometer to the nearest 1/10 mm...
November 2015: Urology
Takashi Yamanaka, Koichiro Yamakado, Tomomi Yamada, Masashi Fujimori, Haruyuki Takaki, Atsuhiro Nakatsuka, Hajime Sakuma, Yoshiki Sugimura
PURPOSE: To retrospectively evaluate factors affecting local tumor control in cryoablation of renal cell carcinomas (RCCs). MATERIALS AND METHODS: This study examined 61 patients (43 men, 18 women) with a mean age of 69.1 years ± 10.8 (range 38-87 y) who underwent computed tomography (CT)-guided percutaneous cryoablation for a single RCC and were followed for 6 months or longer. Maximum tumor diameter was 0.8-4.8 cm (mean ± standard deviation, 2.4 ± 0.9 cm). Factors affecting local tumor control were evaluated...
August 2015: Journal of Vascular and Interventional Radiology: JVIR
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