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https://www.readbyqxmd.com/read/29166764/merkel-cell-carcinoma-metastatic-to-pleural-fluid-a-case-report
#1
Ye-Young Rhee, Soo Hee Kim, Eun Kyung Kim, Se Hoon Kim
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine carcinoma of the skin that shows locoregional and distant metastasis. Metastasis of MCC to body cavity effusion is extremely rare; only three cases had been reported so far. Metastatic MCC in effusion cytology shows small blue round cells with fine stippled chromatin like other small blue round cell tumors such as small cell lung carcinoma or lymphoma. The diagnosis of metastatic MCC could give patients good chances to get recently advanced therapeutic options...
November 23, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29164255/effect-of-an-indwelling-pleural-catheter-vs-talc-pleurodesis-on-hospitalization-days-in-patients-with-malignant-pleural-effusion-the-ample-randomized-clinical-trial
#2
Rajesh Thomas, Edward T H Fysh, Nicola A Smith, Pyng Lee, Benjamin C H Kwan, Elaine Yap, Fiona C Horwood, Francesco Piccolo, David C L Lam, Luke A Garske, Ranjan Shrestha, Christopher Kosky, Catherine A Read, Kevin Murray, Y C Gary Lee
Importance: Indwelling pleural catheter and talc pleurodesis are established treatments for malignant pleural effusions among patients with poor prognosis. Objective: To determine whether indwelling pleural catheters are more effective than talc pleurodesis in reducing total hospitalization days in the remaining lifespan of patients with malignant pleural effusion. Design, Setting, and Participants: This open-label, randomized clinical trial included participants recruited from 9 centers in Australia, New Zealand, Singapore, and Hong Kong between July 2012 and October 2014; they were followed up for 12 months (study end date: October 16, 2015)...
November 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29163783/abundant-expression-of-tim-3-lag-3-pd-1-and-pd-l1-as-immunotherapy-checkpoint-targets-in-effusions-of-mesothelioma-patients
#3
Elly Marcq, Jorrit De Waele, Jonas Van Audenaerde, Eva Lion, Eva Santermans, Niel Hens, Patrick Pauwels, Jan P van Meerbeeck, Evelien L J Smits
Malignant pleural mesothelioma (MPM) is an aggressive cancer with an increasing incidence, poor prognosis and limited effective treatment options. Hence, new treatment strategies are warranted which include immune checkpoint blockade approaches with encouraging preliminary data. Research on the immunological aspects of the easily accessible mesothelioma microenvironment could identify prognostic and/or predictive biomarkers and provide useful insights for developing effective immunotherapy. In this context, we investigated the immune cell composition of effusions (pleural and ascites fluids) from 11 different chemotherapy-treated MPM patients...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163656/the-usefulness-of-thoracic-ultrasonography-in-diagnosis-and-staging-of-bronchogenic-carcinoma
#4
Manal R Hafez, Eman Sm Sobh, Sawsan B Elsawy, Omaima I Abo-Elkheir
Aim: To evaluate (1) the usefulness of thoracic ultrasound in diagnosis and staging of bronchogenic carcinoma by comparing lesion detectability between thoracic- ultrasound and computed tomography and (2) the outcome of thoracic-ultrasound-guided biopsy in diagnosing bronchogenic carcinoma. Methods: We conducted a cross-sectional study on 53 patients of confirmed bronchogenic carcinoma. All patients had been investigated by thoracic-ultrasound and chest-computed tomography; data regarding the presence of mass (its size, necrosis), lymph nodes invasion, peritumoural atelectasis, consolidations, pleural effusion, chest wall invasion, and paralysis of the diaphragm were recorded...
November 2017: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29162908/human-canonical-cd157-bst1-is-an-alternatively-spliced-isoform-masking-a-previously-unidentified-primate-specific-exon-included-in-a-novel-transcript
#5
Enza Ferrero, Nicola Lo Buono, Simona Morone, Rossella Parrotta, Cecilia Mancini, Alfredo Brusco, Alice Giacomino, Stefania Augeri, Antonio Rosal-Vela, Sonia García-Rodríguez, Mercedes Zubiaur, Jaime Sancho, Alessandra Fiorio Pla, Ada Funaro
CD157/Bst1 is a dual-function receptor and β-NAD(+)-metabolizing ectoenzyme of the ADP-ribosyl cyclase family. Expressed in human peripheral blood neutrophils and monocytes, CD157 interacts with extracellular matrix components and regulates leukocyte diapedesis via integrin-mediated signalling in inflammation. CD157 also regulates cell migration and is a marker of adverse prognosis in epithelial ovarian cancer and pleural mesothelioma. One form of CD157 is known to date: the canonical sequence of 318 aa from a 9-exon transcript encoded by BST1 on human chromosome 4...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162443/visualization-of-the-inferoposterior-thoracic-wall-vip-and-boomerang-signs-novel-sonographic-signs-of-right-pleural-effusion
#6
James Siu Ki Lau, Chi Kit Yuen, Ka Leung Mok, Wing Wa Yan, Pui Gay Kan
OBJECTIVES: This study is to present the diagnostic values of the novel sonographic visualization of the inferoposterior thoracic wall (VIP) and boomerang signs in detecting right pleural effusion by sonologists with little to no experience in ultrasound. METHODS: A prospective analysis of a convenience sample of patients who were assessed by junior intensive care physicians was performed. The patients all underwent computed tomography (CT) of the chest or abdomen with lung bases as part of their care regardless of indication; the results were interpreted by radiologists and were considered the gold standard...
November 15, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29161093/b-cells-producing-type-i-interferon-modulate-macrophage-polarization-in-tuberculosis
#7
Alan Bénard, Imme Sakwa, Pablo Schierloh, André Colom, Ingrid Mercier, Ludovic Tailleux, Luc Jouneau, Pierre Boudinot, Talal Al-Saati, Roland Lang, Jan Rehwinkel, Andre G Loxton, Stefan He Kaufmann, Véronique Anton-Leberre, Anne O'Garra, Maria Del Carmen Sasiain, Brigitte Gicquel, Simon Fillatreau, Olivier Neyrolles, Denis Hudrisier
RATIONALE: In addition to their well-known function as antibody-producing cells, B lymphocytes can markedly influence the course of infectious or non-infectious diseases via antibody-independent mechanisms. In tuberculosis, B cells accumulate in lungs, yet their functional contribution to the host response remains poorly understood. OBJECTIVES: To document the role of B cells in tuberculosis in an unbiased manner. METHODS: We generated the transcriptome of B cells isolated from Mycobacterium tuberculosis (Mtb)-infected mice, and validated the identified key pathways using in vitro and in vivo assays...
November 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29159961/primary-pleural-squamous-cell-carcinoma-a-diagnostic-challenge
#8
A Ronchi, I Cozzolino, M Montella, G Vicidomini, F Morgillo, C M Della Corte, R Franco, M Accardo
No abstract text is available yet for this article.
November 21, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29159031/solitary-fibrous-tumor-of-the-abdominal-wall-re-surfacing-as-unilateral-pleural-effusion-and-mass-a-case-report-and-review-of-the-literature
#9
Xia Bi, Jixian Zhai, Carrie D Chun
Background: Solitary fibrous tumors (SFTs) are rare fibroblastic mesenchymal neoplasms that were initially described in the pleura, but have been increasingly recognized to occur in other parts of the body. They have been traditionally regarded as indolent tumors that are rare to metastasize after surgical resection. Here, we describe a case of a Filipino female who initially presented with unilateral pleural effusion and mass, and was ultimately diagnosed with recurrent solitary fibrous tumor that originated from the abdominal wall...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29159011/proton-therapy-for-malignant-pleural-mesothelioma-a-three-case-series-describing-the-clinical-and-dosimetric-advantages-of-proton-based-therapy
#10
Howard Lee, Jing Zeng, Stephen R Bowen, Ramesh Rengan
Malignant pleural mesothelioma (MPM) is a malignancy of the pleural cavity that typically presents at an advanced stage. Due to its large, circumferential clinical target volume (CTV) and proximity to major structures, including the heart and contralateral lung, delivering hemithoracic intensity-modulated radiotherapy (IMRT) with photon therapy to achieve loco-regional control following macroscopic complete resection is challenging. Intensity-modulated proton therapy (IMPT) has been shown to be a method for achieving higher therapeutic doses while limiting exposure to organs at risk (OARs), but patient outcomes after treatment have yet to be reported...
September 20, 2017: Curēus
https://www.readbyqxmd.com/read/29158780/an-interesting-case-of-undiagnosed-pleural-effusion
#11
Amit Panjwani, Thuraya Zaid
Pulmonary embolism is an important cause of undiagnosed pleural effusion http://ow.ly/HDLx30bVVa7.
June 2017: Breathe
https://www.readbyqxmd.com/read/29157885/development-and-validation-of-a-scoring-system-for-the-identification-of-pleural-exudates-of-cardiac-origin
#12
José M Porcel, Lucia Ferreiro, Carme Civit, Luis Valdés, Aureli Esquerda, Richard W Light, Silvia Bielsa
BACKGROUND: Light's criteria misclassify about 30% of cardiac effusions as exudates, possibly leading to unnecessary testing. Our purpose was to derive and validate a scoring model to effectively identify these falsely categorized cardiac effusions, in the setting of natriuretic peptide lacking data. METHODS: We retrospectively analyzed data from 3182 patients with exudative pleural effusions based on Light's criteria, of whom 276 had heart failure (derivation set)...
November 17, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29157454/developing-a-new-intelligent-system-for-the-diagnosis-of-tuberculous-pleural-effusion
#13
Chengye Li, Lingxian Hou, Bishundat Yanesh Sharma, Huaizhong Li, ChengShui Chen, Yuping Li, Xuehua Zhao, Hui Huang, Zhennao Cai, Huiling Chen
BACKGROUND AND OBJECTIVE: In countries with high prevalence of tuberculosis (TB), clinicians often diagnose tuberculous pleural effusion (TPE) by using diagnostic tests, which have not only poor sensitivity, but poor availability as well. The aim of our study is to develop a new artificial intelligence based diagnostic model that is accurate, fast, non-invasive and cost effective to diagnose TPE. It is expected that a tool derived based on the model be installed on simple computer devices (such as smart phones and tablets) and be used by clinicians widely...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29154747/disseminated-methicillin-susceptible-staphylococcus-aureus-infection
#14
David R Perkins, James A Hall, Lisa M Lopez, Lizbeth Janice Cahuayme-Zuniga
INTRODUCTION: When clinicians think about Staphylococcus aureus bacteria, what comes to the mind of most is the dreaded methicillin-resistant form. However, clinicians should not forget the methicillin-susceptible type, which is just as virulent. CASE PRESENTATION: The authors present the case of a 20-year-old woman who was admitted with septic shock and multi-organ failure and was found to have disseminated methicillin-susceptible Staphylococcus aureus (MSSA) infection...
November 20, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29154371/disseminated-nocardiosis-complicated-by-multiple-brain-abscesses-and-pleural-empyema-in-a-young-diabetic-man-a-case-report
#15
M C Mengoli, C Lazzaretti, G Rossi, F Lococo
Nocardiosis is a life-threatening infection usually affecting immunocompromised patients. Very rarely it presented with intracranial abscesses and pleuro-parenchymal infections. We herein report a very challenging case of a 34-year-old obese and diabetic man affected by disseminated nocardiosis with multiple brain abscesses and pleural empyema. Despite rare, this entity should be taken into account by the pathologists and urgently communicated to clinicians in order to promptly start an effective treatment.
September 2017: Pathologica
https://www.readbyqxmd.com/read/29154123/3d-skeletonization-feature-based-computer-aided-detection-system-for-pulmonary-nodules-in-ct-datasets
#16
Weihang Zhang, Xue Wang, Xuanping Li, Junfeng Chen
Pulmonary nodule detection has a significant impact on early diagnosis of lung cancer. To effectively detect pulmonary nodules from interferential vessels in chest CT datasets, this paper proposes a novel 3D skeletonization feature, named as voxels remove rate. Based on this feature, a computer-aided detection system is constructed to validate its performance. The system mainly consists of five stages. Firstly, the lung tissues are segmented by a global optimal active contour model, which can extract all structures (including juxta-pleural nodules) in the lung region...
November 11, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29153564/sex-dimorphism-in-the-myocardial-response-to-aortic-stenosis
#17
Thomas A Treibel, Rebecca Kozor, Marianna Fontana, Camilla Torlasco, Patricia Reant, Sveeta Badiani, Maria Espinoza, John Yap, Javier Diez, Alun D Hughes, Guy Lloyd, James C Moon
OBJECTIVES: The goal of this study was to explore sex differences in myocardial remodeling in aortic stenosis (AS) by using echocardiography, cardiac magnetic resonance (CMR), and biomarkers. BACKGROUND: AS is a disease of both valve and left ventricle (LV). Sex differences in LV remodeling are reported in AS and may play a role in disease phenotyping. METHODS: This study was a prospective assessment of patients awaiting surgical valve replacement for severe AS using echocardiography, the 6-min walking test, biomarkers (high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide), and CMR with late gadolinium enhancement and extracellular volume fraction, which dichotomizes the myocardium into matrix and cell volumes...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29152039/hepatic-hydrothorax-an-update-and-review-of-the-literature
#18
REVIEW
Dmitry Victorovich Garbuzenko, Nikolay Olegovich Arefyev
This review considers the modern concepts of pathogenesis, diagnostic methods, and treatment principles of hepatic hydrothorax (HH). HH is the excessive (> 500 mL) accumulation of transudate in the pleural cavity in patients with decompensated liver cirrhosis but without cardiopulmonary and pleural diseases. It causes respiratory failure which aggravates the clinical course of liver cirrhosis, and the emergence of spontaneous bacterial pleural empyema may be the cause of death. The information was collected from the PubMed database, the Google Scholar retrieval system, the Cochrane reviews, and the reference lists from relevant publications for 1994-2016 using the keywords: "liver cirrhosis", "portal hypertension", "hepatic hydrothorax", "pathogenesis", "diagnostics", and "treatment"...
November 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29151304/egfr-kras-and-braf-mutational-profiles-of-female-patients-with-micropapillary-predominant-invasive-lung-adenocarcinoma
#19
(no author information available yet)
Background/aim: This study aimed to analyze EGFR, KRAS, and BRAF mutations in females with micropapillary predominant invasive lung adenocarcinoma and their relationships with immunohistochemical and clinicopathological patterns.Materials and methods: A total of 15 females with micropapillary lung adenocarcinoma were selected. Mutational analysis of the EGFR, KRAS, and BRAF genes was carried out. Information regarding the demographic data, tumor size, treatment, and survival time for each patient was collated, and the predominant cell type, secondary architectural growth patterns, psammoma bodies, necrosis, and visceral pleural and angiolymphatic invasions were evaluated...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151104/clinical-efficacy-and-safety-of-first-line-dasatinib-therapy-and-the-relevance-of-velocity-of-bcr-abl1-transcript-decline-for-achievement-of-molecular-responses-in-newly-diagnosed-chronic-phase-chronic-myeloid-leukemia-report-from-the-juntendo-yamanashi-cooperative
#20
Tomoiku Takaku, Noriyoshi Iriyama, Toru Mitsumori, Eriko Sato, Akihiko Gotoh, Keita Kirito, Masaaki Noguchi, Michiaki Koike, Junichi Sakamoto, Koji Oba, Norio Komatsu
OBJECTIVE: The use of tyrosine kinase inhibitors led to an improvement in the prognoses of patients with chronic myeloid leukemia (CML). The aims of this study were to investigate the efficacy and safety of dasatinib in Japanese patients and to explore the factors that affect the achievement of molecular responses. METHODS: The primary endpoint was a major molecular response (MMR) by 12 months. The halving time for BCR-ABL1 transcripts was calculated using transcript levels...
November 18, 2017: Oncology
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