keyword
https://read.qxmd.com/read/38459356/clinical-characteristics-of-patients-with-connective-tissue-disease-related-interstitial-lung-disease-a-retrospective-analysis
#1
JOURNAL ARTICLE
Seda Colak, Emre Tekgoz, Ezgi Cimen Gunes, Nesrin Ocal, Deniz Dogan, Canturk Tasci, Muhammet Cinar, Sedat Yilmaz
INTRODUCTION: Interstitial lung disease is one of the most critical manifestations of connective tissue diseases that may cause morbidity and mortality. This study aimed to evaluate the clinical and demographic characteristics and treatment of the patients with connective tissue disease-related interstitial lung disease. METHOD: This retrospective observational study included patients from the Gulhane Rheumatology Interstitial Lung Disease cohort between October 2016 and June 2023...
March 9, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38446195/the-relationship-between-anti-ssa-52-and-interstitial-lung-disease
#2
JOURNAL ARTICLE
Hollie Saunders, Hassan Baig, Yan Li, Launia White, David Hodge, Elizabeth Lesser, Justin T Stowell, Carlos A Rojas, Isabel Mira-Avendano
OBJECTIVE: The aims of this study were to assess whether a relationship between anti-SSA-52 and interstitial lung disease (ILD) can be further defined, and to enhance screening, detection, and potentially guide treatment. METHODS: A historical cohort study of 201 patients was conducted at a single tertiary care center between January 1, 2016 and December 31, 2020. All included patients were anti-SSA-52 antibody positive. Chart review was performed for laboratory values, symptoms, pulmonary function tests, treatment, and imaging...
March 5, 2024: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://read.qxmd.com/read/38415479/evaluation-of-interstitial-lung-diseases-with-deep-learning-method-of-two-major-computed-tomography-patterns
#3
JOURNAL ARTICLE
Hüseyin Alper Kiziloğlu, Emrah Çevik, Kenan Zengin
BACKGROUND: Interstitial lung diseases (ILD) encompass various disorders characterized by inflammation and/or fibrosis in the lung interstitium. These conditions produce distinct patterns in High-Resolution Computed Tomography (HRCT). OBJECTIVE: We employ a deep learning method to diagnose the most commonly encountered patterns in ILD differentially. MATERIALS AND METHODS: Patients were categorized into usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), and normal lung parenchyma groups...
February 26, 2024: Current medical imaging
https://read.qxmd.com/read/38410568/surgical-lung-biopsy-for-suspected-interstitial-lung-disease-with-video-assisted-thoracoscopic-surgery-is-safe-providing-exact-histological-and-disease-specific-diagnosis-for-tailoring-treatment
#4
JOURNAL ARTICLE
Leifur Thrainsson, Arnljotur Bjorn Halldorsson, Arnar Bragi Ingason, Helgi J Isaksson, Gunnar Gudmundsson, Tomas Gudbjartsson
BACKGROUND: Surgical lung biopsy (SLB) is required for diagnosis in patients with suspected interstitial lung disease (ILD) if other less invasive diagnostic methods are non-conclusive. We evaluated the outcome of SLB by using centralized databases in a whole-nation patient-cohort. METHODS: A population-based retrospective study on 68 consecutive patients (mean age 58 years, 58.8% males) that underwent SLB in Iceland between the years 2008 and 2020. Patient information was obtained from patient charts and peri- and postoperative complications were registered together with 30- and 90-day mortality...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38408707/radiological-and-histopathological-features-and-treatment-response-by-subtypes-of-interstitial-pneumonia-with-autoimmune-features-a-prospective-multicentre-cohort-study
#5
JOURNAL ARTICLE
Noriyuki Enomoto, Shusuke Yazawa, Yasutaka Mochizuka, Atsuki Fukada, Yuko Tanaka, Hyogo Naoi, Yuya Aono, Yusuke Inoue, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Kazuki Furuhashi, Mikio Toyoshima, Masato Kono, Shiro Imokawa, Takehisa Sano, Taisuke Akamatsu, Naoki Koshimizu, Koshi Yokomura, Hiroyuki Matsuda, Yusuke Kaida, Masahiro Shirai, Kazutaka Mori, Masafumi Masuda, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Hiroaki Sugiura, Hiromitsu Sumikawa, Masashi Kitani, Kazuhiro Tabata, Noriyoshi Ogawa, Takafumi Suda
BACKGROUND: Patients with idiopathic interstitial pneumonia (IIP) have a favourable prognosis when they have interstitial pneumonia with autoimmune features (IPAF). However, precise IPAF-related findings from high-resolution computed tomography (HRCT) and lung histopathological specimens and the treatment response have not been fully determined. Therefore, this study was conducted to evaluate the relationship between findings on HRCT or lung histopathological specimens and the progression of interstitial pneumonia in patients with IPAF...
February 24, 2024: Respiratory Medicine
https://read.qxmd.com/read/38384315/clustered-cystic-changes-in-long-term-follow-up-thin-section-computed-tomographic-findings-in-fibrotic-nonspecific-interstitial-pneumonia
#6
JOURNAL ARTICLE
Masanori Akira, Narufumi Suganuma
OBJECTIVES: The purpose of this study was to retrospectively assess cystic changes in findings on follow-up CT scans of patients with fibrotic nonspecific interstitial pneumonia (NSIP). METHODS: The initial and last high-resolution CT scans of 58 patients with pathologically proven fibrotic NSIP were evaluated retrospectively. The median follow-up periods were 48 months (range, 12-183 months). The pattern, extent, and distribution of abnormal CT findings were compared with findings in the same region on previous and subsequent CT scans with a focus on cystic lesions...
2024: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/38368559/can-subcutaneous-treprostinil-be-an-alternative-for-treating-pulmonary-hypertension-in-patients-with-systemic-sclerosis-related-interstitial-lung-disease
#7
JOURNAL ARTICLE
Ana Catarina Duarte, Sofia Alegria, Filipe Vinagre, Filipa Ferreira, Ana Cordeiro
Pulmonary hypertension (PH) is one of the most feared complications of systemic sclerosis (SSc). There are currently specific drugs approved for PH group I (pulmonary arterial hypertension - PAH), but for PH related to lung disease (group III) the use of vasodilators is still controversial and not routinely recommended in patients with non-severe PH. However, SSc-PH-interstitial lung disease (ILD) has a poorer survival compared with SSc-PAH, making the management of these patients a challenge, ideally carried out in a reference centre...
February 13, 2024: ARP Rheumatol
https://read.qxmd.com/read/38345107/similarities-and-differences-of-interstitial-lung-disease-associated-with-pathogenic-variants-in-sftpc-and-abca3-in-adults
#8
JOURNAL ARTICLE
Rémi Diesler, Marie Legendre, Salim Si-Mohamed, Pierre-Yves Brillet, Lidwine Wemeau, Effrosyni D Manali, Frédéric Gagnadoux, Sandrine Hirschi, Gwenaël Lorillon, Martine Reynaud-Gaubert, Vanessa Bironneau, Elodie Blanchard, Arnaud Bourdin, Stéphane Dominique, Aurélien Justet, Julie Macey, Sylvain Marchand-Adam, Hélène Morisse-Pradier, Hilario Nunes, Spyros A Papiris, Julie Traclet, Ibrahim Traore, Bruno Crestani, Serge Amselem, Nadia Nathan, Raphaël Borie, Vincent Cottin
BACKGROUND AND OBJECTIVE: Variants in surfactant genes SFTPC or ABCA3 are responsible for interstitial lung disease (ILD) in children and adults, with few studies in adults. METHODS: We conducted a multicentre retrospective study of all consecutive adult patients diagnosed with ILD associated with variants in SFTPC or ABCA3 in the French rare pulmonary diseases network, OrphaLung. Variants and chest computed tomography (CT) features were centrally reviewed. RESULTS: We included 36 patients (median age: 34 years, 20 males), 22 in the SFTPC group and 14 in the ABCA3 group...
February 12, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/38290874/pulmonary-manifestations-and-prognosis-of-a-cohort-of-patients-with-interstitial-lung-disease-and-positive-to-anti-th-to-autoantibodies
#9
JOURNAL ARTICLE
Mayra Mejía, Espiridión Ramos-Martínez, Leilany E Vázquez-Becerra, Deni Fernández-Badillo, Heidegger N Mateos-Toledo, Jhonatan Castillo, Andrea Estrada, Jorge Rojas-Serrano
INTRODUCTION: Th/To autoantibody may be relevant in evaluating patients with interstitial lung disease (ILD) because the clinical diagnosis of systemic sclerosis (SSc) may not be evident. The study's objective was to describe manifestations and evolution of pulmonary function in a cohort of ILD patients positive for Th/To autoantibodies. METHODS: ILD patients positive for anti-Th/To autoantibody were enrolled in this protocol. Baseline clinical features were registered, and survival analysis was performed to identify risk factors associated with worse survival...
January 29, 2024: Medicina Clínica
https://read.qxmd.com/read/38290451/clinical-observational-study-on-the-therapeutic-efficacy-of-pirfenidone-in-sj%C3%A3-gren-s-syndrome-complicated-with-nonspecific-interstitial-pneumonia
#10
JOURNAL ARTICLE
Wei Wei, Wei Zou, Wei Han, Jingjing Liu
OBJECTIVE: This study aimed to evaluate the therapeutic impact of pirfenidone in patients with nonspecific interstitial pneumonia (NSIP) secondary to Sjögren's syndrome, comparing its effectiveness against conventional treatments. METHODS: A controlled clinical trial was conducted on a cohort of patients diagnosed with primary Sjögren's syndrome complicated by interstitial lung disease. The study included a total of 120 patients, divided equally into two groups: a control group comprising 60 patients and an observation group with another 60 patients...
January 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38262268/histopathological-significance-of-connective-tissue-disease-associated-interstitial-lung-disease-in-transbronchial-lung-cryobiopsy-specimens
#11
JOURNAL ARTICLE
Hiroyuki Katsuragawa, Shinji Sumiyoshi, Naoya Ikegami, Seishu Hashimoto, Takashi Hajiro, Yoshio Taguchi, Yoichiro Kobashi, Hironori Haga, Akihiko Yoshizawa
Differentiating between idiopathic interstitial pneumonia (IIP) and secondary interstitial pneumonia, particularly connective tissue disease-associated interstitial lung disease (CTD-ILD), can be challenging histopathologically, and there may be discrepancies among pathologists. While surgical lung biopsy has traditionally been considered the gold standard for diagnosing interstitial pneumonia, the usefulness of transbronchial lung cryobiopsy (TBLC) has been reported. If TBLC could effectively distinguish between primary and secondary diseases, it would provide a less invasive option for patients...
January 2, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38226064/real-world-experience-of-nintedanib-for-progressive-fibrosing-interstitial-lung-disease-in-the-uk
#12
JOURNAL ARTICLE
Giles Dixon, Samuel Hague, Sarah Mulholland, Huzaifa Adamali, Aye Myat Noe Khin, Hannah Thould, Roisin Connon, Paul Minnis, Eoin Murtagh, Fasihul Khan, Sameen Toor, Alexandra Lawrence, Marium Naqvi, Alex West, Robina K Coker, Katie Ward, Leda Yazbeck, Simon Hart, Theresa Garfoot, Kate Newman, Pilar Rivera-Ortega, Lachlan Stranks, Paul Beirne, Jessica Bradley, Catherine Rowan, Sarah Agnew, Mahin Ahmad, Lisa G Spencer, Joshua Aigbirior, Ahmed Fahim, Andrew M Wilson, Elizabeth Butcher, Sy Giin Chong, Gauri Saini, Sabrina Zulfikar, Felix Chua, Peter M George, Maria Kokosi, Vasileios Kouranos, Philip Molyneaux, Elisabetta Renzoni, Benedetta Vitri, Athol U Wells, Lisa M Nicol, Stephen Bianchi, Raman Kular, HuaJian Liu, Alexander John, Sarah Barth, Melissa Wickremasinghe, Ian A Forrest, Ian Grimes, A John Simpson, Sophie V Fletcher, Mark G Jones, Emma Kinsella, Jennifer Naftel, Nicola Wood, Jodie Chalmers, Anjali Crawshaw, Louise E Crowley, Davinder Dosanjh, Christopher C Huntley, Gareth I Walters, Timothy Gatheral, Catherine Plum, Shiva Bikmalla, Raja Muthusami, Helen Stone, Jonathan C L Rodrigues, Krasimira Tsaneva-Atanasova, Chris J Scotton, Michael A Gibbons, Shaney L Barratt
BACKGROUND: Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial lung disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service in Scotland in June 2021 and in England, Wales and Northern Ireland in November 2021. To date, there has been no national evaluation of the use of nintedanib for PF-ILD in a real-world setting. METHODS: 26 UK centres were invited to take part in a national service evaluation between 17 November 2021 and 30 September 2022...
January 2024: ERJ Open Research
https://read.qxmd.com/read/38193329/s100-calcium-binding-protein-a9-a-potential-novel-diagnostic-biomarker-for-idiopathic-pulmonary-fibrosis
#13
JOURNAL ARTICLE
Jong-Uk Lee, Min Kyung Kim, Myung-Shin Kim, Sun Ju Lee, Seung-Lee Park, Hun Soo Chang, Jong-Sook Park, Choon-Sik Park
BACKGROUND: Neutrophilic inflammation is a characteristic feature of idiopathic pulmonary fibrosis (IPF). S100 calcium-binding protein A9 (S100A9) is a neutrophil-derived protein involved in the development of neutrophil-related chronic inflammatory disorders. However, the role of S100A9 in IPF remains unclear. METHODS: We used enzyme-linked immunosorbent assays to measure S100A9 levels in bronchoalveolar lavage fluid (BALF) and serum obtained from healthy controls (HCs) and patients with IPF, non-specific interstitial pneumonia, hypersensitivity pneumonitis, and sarcoidosis...
January 8, 2024: Journal of Korean Medical Science
https://read.qxmd.com/read/38183005/ild-gap-combined-with-the-monocyte-ratio-could-be-a-better-prognostic-prediction-model-than-ild-gap-in-patients-with-interstitial-lung-diseases
#14
JOURNAL ARTICLE
Momo Hirata, Yu Hara, Hiroaki Fujii, Kota Murohashi, Yusuke Saigusa, Shiqi Zhao, Miyu Kobayashi, Ryo Nagasawa, Yoichi Tagami, Ami Izawa, Yukiko Otsu, Keisuke Watanabe, Nobuyuki Horita, Nobuaki Kobayashi, Takeshi Kaneko
BACKGROUND: The ILD-GAP scoring system is known to be useful in predicting prognosis in patients with interstitial lung disease (ILD). An elevated monocyte count was associated with increased risks of IPF poor prognosis. We examined whether the ILD-GAP scoring system combined with the monocyte ratio (ILD-GAPM) is superior to the conventional ILD-GAP model in predicting ILD prognosis. METHODS: In patients with ILD treated between April 2013 and April 2017, we were retrospectively assessed the relationships between baseline clinical parameters, including age, sex, Charlson Comorbidity Index score (CCIS), ILD diagnosis, blood biomarkers, pulmonary function test results, and disease outcomes...
January 5, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38161571/gradually-progressive-interstitial-pneumonia-following-covid-19-in-an-older-patient-a-case-report
#15
Takeshi Mori, Fumiko Yamane, Chiaki Sano, Ryuichi Ohta
Since its confirmation in Wuhan, Hubei Province, China, at the end of 2019, the novel coronavirus disease (COVID-19) has rapidly spread worldwide in multiple epidemic waves while undergoing mutations. To date, numerous individuals have been infected. Symptoms range from asymptomatic and common cold-like to acute respiratory failure and acute respiratory distress syndrome (ARDS), which can lead to death. Here, we present the case of an 81-year-old woman with a fever that persisted for more than five days after infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)...
December 2023: Curēus
https://read.qxmd.com/read/38156131/combination-therapy-with-erlotinib-and-ramucirumab-in-a-patient-with-epidermal-growth-factor-receptor-mutation-positive-lung-adenocarcinoma-and-interstitial-pneumonia-a-case-report
#16
Shunya Tanaka, Taisuke Tsuji, Kazuki Jinno, Shoki Matsumoto
Interstitial pneumonia often acts as a barrier to lung cancer treatment. We report the case of a 79-year-old man who was diagnosed with epidermal growth factor receptor (EGFR) mutation positive lung adenocarcinoma (T2aN0M0, stage ⅠB, EGFR exon 19 deletion), and was positive for anti-aminoacyl-tRNA synthetase antibodies with interstitial pneumonia. Metastasis in the right seventh rib was detected three months after surgical resection and radiation therapy was initiated. As recurrence was observed at both ends of the radiation field five months later, combination chemotherapy with erlotinib and ramucirumab was initiated...
November 2023: Curēus
https://read.qxmd.com/read/38144909/role-of-multidisciplinary-team-meetings-in-the-diagnosis-and-management-of-diffuse-parenchymal-lung-diseases-in-a-tertiary-care-hospital
#17
JOURNAL ARTICLE
Mohammad Ayaz Khan, Nahid Sherbini, Sami Alyami, Abdullah Al-Harbi, Suliman Alrajhi, Reem Abdullah, Dhafer AlGhamdi, Rajkumar Rajendram, Hana Bamefleh, Hamdan Al-Jahdali
Background  Decisions on the management of interstitial lung diseases (ILD) and prognostication require an accurate diagnosis. It has been proposed that multidisciplinary team (MDT) meetings for ILD (ILD-MDT) improve these decisions in challenging cases of ILD. However, most studies in this field have been based on the decisions of individual clinicians and there are few reports on the outcomes of the ILD-MDT approach. We therefore describe the experience of the ILD-MDT meetings at our institution. Methods  A single-center retrospective review of the electronic health care records of patients discussed in the ILD-MDT meetings at our institution from February 2016 to January 2021 was performed...
October 2023: Avicenna Journal of Medicine
https://read.qxmd.com/read/38091126/respiratory-infection-risk-in-primary-sj%C3%A3-gren-s-syndrome-complicated-with-interstitial-lung-disease-a-retrospective-study
#18
JOURNAL ARTICLE
Xingyu Zhou, Hao Li, Naidi Wang, Yuebo Jin, Jing He
OBJECTIVES: To explore clinical and laboratory characteristics of primary Sjögren's syndrome (pSS) complicated with interstitial lung disease (ILD) and investigate the risk factors for respiratory infections in pSS-ILD. METHODS: A cohort of 162 pSS-ILD patients in Peking University People's Hospital from 2015 to 2020 were included, and all medical records were completely collected. We screened 53 patients suffering from respiratory infections as study cases, compared with 109 age- and sex-matched controls...
February 2024: Clinical Rheumatology
https://read.qxmd.com/read/38068534/predictors-of-interstitial-lung-disease-in-mixed-connective-tissue-disease
#19
JOURNAL ARTICLE
Manuel Silvério-António, Joana Martins-Martinho, Ana Teresa Melo, Francisca Guimarães, Eduardo Dourado, Daniela Oliveira, Jorge Lopes, André Saraiva, Ana Gago, Margarida Correia, Ana L Fernandes, Sara Dinis, Rafaela Teixeira, Susana P Silva, Carlos Costa, Tiago Beirão, Carolina Furtado, Pedro Abreu, Carmo Afonso, Nikita Khmelinskii
Interstitial lung disease (ILD) frequently complicates mixed connective tissue disease (MCTD) and contributes to increased mortality. We aimed to identify predictors of ILD in MCTD patients. This is a nationwide, multicentre, retrospective study including patients with an adult-onset MCTD clinical diagnosis who met Sharp's, Kasukawa, Alarcón-Segovia, or Kahn's diagnostic criteria and had available chest high-resolution computed tomography (HRCT) data. Univariate and multivariate analyses were conducted...
December 3, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38046148/factors-associated-with-rapid-progression-in-fibrotic-interstitial-lung-disease
#20
JOURNAL ARTICLE
Xianqiu Chen, Qiuliang Ji, Qian Yao, Ying Zhou
BACKGROUND: Early identification of fibrotic interstitial lung disease (F-ILD) patients with high risk of progression will help initiate early therapeutic intervention and potential improvement of outcomes. This study was designed to assess the predictors of progression in patients with F-ILD. METHODS: Patients with F-ILD in Shanghai Pulmonary Hospital between January 1, 2019 and July 31, 2021 were retrospectively analyzed. The patients enrolled were divided into progressive group and non-progressive group according to the specified criteria...
December 2023: Heliyon
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