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https://www.readbyqxmd.com/read/19474621/acute-pancreatitis
#1
Teresa Berkley, Kimberly Klamut
No abstract text is available yet for this article.
June 2009: Nursing
https://www.readbyqxmd.com/read/18281530/nuclear-factor-y-and-epstein-barr-virus-in-nasopharyngeal-cancer
#2
Marie C Chia, Abby Leung, Tiffany Krushel, Nehad M Alajez, Kwok W Lo, Pierre Busson, Henry J Klamut, Carlo Bastianutto, Fei-Fei Liu
PURPOSE: The Epstein Barr virus (EBV) is intimately associated with nasopharyngeal cancer (NPC) in a latent state expressing a limited number of genes. The process of switching from latency to replication is not well understood, particularly in response to DNA stress; hence, the focus of this study is on an EBV-positive NPC model. EXPERIMENTAL DESIGN: C666-1 cells were exposed to radiation (2-15 Gy) or cisplatin (0.1-50 microg/mL) assayed subsequently for relative EBV copy number (BamHI) and lytic gene expression (BRLF1 and BZLF1) using quantitative real-time PCR...
February 15, 2008: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/17637718/sca-1-hematopoietic-cell-based-gene-therapy-with-a-modified-fgf-2-increased-endosteal-trabecular-bone-formation-in-mice
#3
Susan L Hall, Kin-Hing William Lau, Shin-Tai Chen, Jon E Wergedal, Apurva Srivastava, Henry Klamut, Matilda H-C Sheng, Daila S Gridley, Subburaman Mohan, David J Baylink
This study assessed the feasibility of using an ex vivo stem cell antigen-1-positive (Sca-1(+)) cell-based systemic fibroblast growth factor-2 (FGF-2) gene therapy to promote endosteal bone formation. Sca-1(+) cells were used because of their ability to home to, and engraft into, the bone marrow cavity. The human FGF-2 gene was modified to increase protein secretion and stability by adding the bone morphogenic protein (BMP)-2/4 hybrid signal sequence and by mutating two key cysteines. Retro-orbital injection of Sca-1(+) cells transduced with a Moloney leukemia virus (MLV)-based vector expressing the modified FGF-2 gene into sub-lethally irradiated W(41)/W(41) recipient mice resulted in long-term engraftment, more than 100-fold elevation in serum FGF-2 level, increased serum bone-formation markers, and massive endosteal bone formation...
October 2007: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/16319142/inhibition-of-mechanosensitive-cation-channels-inhibits-myogenic-differentiation-by-suppressing-the-expression-of-myogenic-regulatory-factors-and-caspase-3-activity
#4
Nia Wedhas, Henry J Klamut, Charu Dogra, Apurva K Srivastava, Subburaman Mohan, Ashok Kumar
Mechanosensitive cation channels (MSC) are ubiquitous in eukaryotic cell types. However, the physiological functions of MSC in several tissues remain in question. In this study we have investigated the role of MSC in skeletal myogenesis. Treatment of C2C12 myoblasts with gadolinium ions (MSC blocker) inhibited myotube formation and the myogenic index in differentiation medium (DM). The enzymatic activity of creatine kinase (CK) and the expression of myosin heavy chain-fast twitch (MyHCf) in C2C12 cultures were also blocked in response to gadolinium...
December 2005: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/15831470/integrin-linked-kinase-mediates-bone-morphogenetic-protein-7-dependent-renal-epithelial-cell-morphogenesis
#5
Chungyee Leung-Hagesteijn, Ming Chang Hu, Ahalya S Mahendra, Sunny Hartwig, Henry J Klamut, Norman D Rosenblum, Gregory E Hannigan
Bone morphogenetic protein 7 (BMP7) stimulates renal branching morphogenesis via p38 mitogen-activated protein kinase (p38(MAPK)) and activating transcription factor 2 (ATF-2) (M. C. Hu, D. Wasserman, S. Hartwig, and N. D. Rosenblum, J. Biol. Chem. 279:12051-12059, 2004). Here, we demonstrate a novel role for integrin-linked kinase (ILK) in mediating renal epithelial cell morphogenesis in embryonic kidney explants and identify p38(MAPK) as a target of ILK signaling in a cell culture model of renal epithelial morphogenesis...
May 2005: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/15194047/a-conditionally-replicating-adenovirus-for-nasopharyngeal-carcinoma-gene-therapy
#6
Marie C Chia, Wei Shi, Jian-Hua Li, Otto Sanchez, Craig A Strathdee, Dolly Huang, Pierre Busson, Henry J Klamut, Fei-Fei Liu
Successful attainment of tumor-specific gene expression was achieved in nasopharyngeal carcinoma (NPC) by exploiting the exclusive presence of the Epstein-Barr virus (EBV) genome in the cancer cells. In the current study, we have utilized an EBV-dependent transcriptional targeting strategy to construct a novel conditionally replicating adenovirus, adv.oriP.E1A. After treatment with adv.oriP.E1A, we observed extensive cell death in the EBV-positive NPC cell line C666-1. In contrast, no cytotoxicity was observed in a panel of other human EBV-negative cell lines, including fibroblasts from the nasopharynx...
June 2004: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/15104530/progress-toward-skeletal-gene-therapy
#7
REVIEW
Henry J Klamut, Shin-Tai Chen, K-H William Lau, David J Baylink
Skeletal gene therapy is an attractive new approach to the treatment of bone disorders. Impressive advances in our knowledge of the molecular genetic basis of skeletal disorders and fracture healing have led to the development of novel therapeutics based on ectopic expression of one or more genes in patient cells that can influence repair or regenerative processes in bone. Although still a relatively immature field, proof-of-principle for enhanced bone formation through skeletal gene therapy has already been established...
2004: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/14681726/kinase-dead-pkb-gene-therapy-combined-with-hyperthermia-for-human-breast-cancer
#8
Nancy Ma, Paul Szmitko, Anthony Brade, Isabel Chu, Alex Lo, Jim Woodgett, Henry Klamut, Fei-Fei Liu
We have previously demonstrated that protein kinase B (PKB) is a mediator of heat-induced apoptosis for human breast cancer cells. To investigate the therapeutic potential of abrogating the function of this important survival protein, a novel replication-deficient adenovirus was constructed, wherein a mutant, kinase-inactive PKB gene (AAA) was inserted downstream of the CMV promoter. Two human breast cancer cell lines, MCF-7 and MDA-468, were treated, along with the MCF-10 serving as a "normal" mammary epithelial comparator...
January 2004: Cancer Gene Therapy
https://www.readbyqxmd.com/read/14664799/efficacy-of-targeted-fasl-in-nasopharyngeal-carcinoma
#9
Jian-Hua Li, Wei Shi, Marie Chia, Otto Sanchez-Sweatman, Christopher Siatskas, Dolly Huang, Pierre Busson, Henry Klamut, Wen-Chen Yeh, Chris Richardson, Brian O'Sullivan, Pat Gullane, Peter Neligan, Jeff Medin, Fei-Fei Liu
We have successfully achieved selective gene expression in human nasopharyngeal carcinoma (NPC) by exploiting the presence of the Epstein-Barr virus (EBV), utilizing a transcriptional targeting strategy (J. H. Li et al., 2002, Cancer Res. 62: 171). Building on this platform, we have generated a novel DeltaE1 adenoviral vector mediating the expression of a mutant noncleavable form of the FasL gene (HUGO-approved symbol TNFSF6) (ad5oriP.ncFasL). We observe that this therapy induces significant cytotoxicity in the EBV-positive NPC cell line C666-1, mediated by the induction of caspase-dependent apoptosis...
December 2003: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/14578461/p16-gene-therapy-a-potentially-efficacious-modality-for-nasopharyngeal-carcinoma
#10
Andrew Wing Cheong Lee, Jian-Hua Li, Willa Shi, Anna Li, Emily Ng, Ta-Jen Liu, Henry J Klamut, Fei-Fei Liu
p16 is an important regulator of the cell cycle at the G(1) phase. Frequent aberration of p16 in nasopharyngeal carcinoma (NPC) suggests a role for this tumor suppressor gene in disease development. p16 gene transfer has been demonstrated to be effective in various human cancer models, including breast, lung, and prostate, causing cell cycle arrest, apoptosis, and tumor growth delay. We investigated the potential of adenoviral-mediated p16 therapy, in combination with ionizing radiation (RT), in two distinct NPC models...
October 2003: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/14456635/-mechanical-drum-seriograph-of-the-polish-production
#11
M KLAMUT
No abstract text is available yet for this article.
November 1961: Polski Przegla̜d Radiologii i Medycyny Nuklearnej
https://www.readbyqxmd.com/read/14340009/-the-cineradiographic-method-of-studying-the-time-of-pulmonary-circulation
#12
M WAZNY, S KOPER, M KLAMUT
No abstract text is available yet for this article.
March 1965: Acta Physiologica Polonica
https://www.readbyqxmd.com/read/14289871/-2-cases-of-osteomyelosclerosis
#13
M KLAMUT, J STASZYC, ZIOLKIEWICZ SZYMANKOWA
No abstract text is available yet for this article.
September 1964: Polski Przegla̜d Radiologii i Medycyny Nuklearnej
https://www.readbyqxmd.com/read/14202975/-controlled-diagnostic-pneumomediastinum
#14
M KLAMUT, P MISIUNA
No abstract text is available yet for this article.
August 3, 1964: Polski Tygodnik Lekarski
https://www.readbyqxmd.com/read/14190177/-klippel-tr-enaunay-syndrome
#15
A PANECKA, M KLAMUT, D RAKOWSKA
No abstract text is available yet for this article.
July 13, 1964: Polski Tygodnik Lekarski
https://www.readbyqxmd.com/read/14185153/-intermediate-angiography-of-the-vertebral-artery
#16
S BRYC, M CZOCHRA, M KLAMUT
No abstract text is available yet for this article.
January 27, 1964: Polski Tygodnik Lekarski
https://www.readbyqxmd.com/read/14099209/-clinical-value-of-transcutaneous-transhepatic-cholangiography
#17
M ZAKRYS, M KLAMUT
No abstract text is available yet for this article.
October 28, 1963: Polski Tygodnik Lekarski
https://www.readbyqxmd.com/read/14033274/-hereditary-generalized-osteosclerosis-observed-in-3-generations
#18
M KLAMUT, K RUDNICKA-CHOMICZ
No abstract text is available yet for this article.
November 19, 1962: Polski Tygodnik Lekarski
https://www.readbyqxmd.com/read/14033273/-a-technic-for-right-vertebral-arteriography-with-the-aid-of-carotid-catherization
#19
M KLAMUT, M CZOCHRA, S BRYC, E ZDERKIEWICZ
No abstract text is available yet for this article.
September 1962: Neurologia, Neurochirurgia i Psychiatria Polska
https://www.readbyqxmd.com/read/14033272/-angiography-of-the-left-vertebral-artery-with-catheterization-of-the-femoral-artery
#20
M KLAMUT, S BRYC, M CZOCHRA, A MUSZYNSKI
No abstract text is available yet for this article.
July 1962: Polski Przegla̜d Radiologii i Medycyny Nuklearnej
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