Kazuki Nagata, Daisuke Ando, Tsubasa Ashikari, Kandai Ito, Ryosuke Miura, Izumi Fujigaki, Yuki Goto, Miki Ando, Naoto Ito, Hibiki Kawazoe, Yuki Iizuka, Mariko Inoue, Takuya Yashiro, Masakazu Hachisu, Kazumi Kasakura, Chiharu Nishiyama
Short-chain fatty acids (SCFAs) are produced by the intestinal microbiota during the fermentation of dietary fibers as secondary metabolites. Several recent studies reported that SCFAs modulate the development and function of immune-related cells. However, the molecular mechanisms by which SCFAs regulate mast cells (MCs) remain unclear. In the current study, we analyzed the function and gene expression of mouse MCs in the presence of SCFAs in vitro and in vivo. We found that the oral administration of valerate or butyrate ameliorated passive systemic anaphylaxis and passive cutaneous anaphylaxis in mice...
January 10, 2024: Journal of Immunology