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https://www.readbyqxmd.com/read/29792999/does-solid-fusion-eliminate-rod-fracture-after-pedicle-subtraction-osteotomy-in-ankylosing-spondylitis-related-thoracolumbar-kyphosis
#1
Shi-Zhou Zhao, Bang-Ping Qian, Mu Qiao, Jun Jiang, Yong Qiu
BACKGROUND CONTEXT: Rod fracture (RF) has a negative impact on the surgical outcome of ankylosing spondylitis (AS) patients following lumbar pedicle subtraction osteotomy (PSO). However, there is a paucity of published studies analyzing the risk factors for RF in PSO-treated AS patients with thoracolumbar kyphosis. PURPOSE: To investigate the risk factors for RF after PSO for thoracolumbar kyphosis secondary to AS. STUDY DESIGN/SETTING: Retrospective single-center study...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792998/bmi-and-gender-increase-risk-for-sacral-fractures-after-multilevel-instrumented-spinal-fusion-compared-to-bone-mineral-density-and-pelvic-parameters
#2
Stephan N Salzmann, Courtney Ortiz Miller, John A Carrino, Jingyan Yang, Jennifer Shue, Andrew A Sama, Frank P Cammisa, Federico P Girardi, Alexander P Hughes
BACKGROUND CONTEXT: Sacral fractures are a rare but potentially devastating complication. Long-fusion constructs including the sacrum that do not extend to the pelvis may result in sacral fractures. Besides established risk factors including gender, age and number of levels fused, body mass index (BMI), pelvic parameters and bone mineral density (BMD) have also been proposed as potential risk factors for postoperative sacral fractures. The literature supporting this, however, is limited...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792965/characterization-sulfated-modification-and-bioactivity-of-a-novel-polysaccharide-from-millettia-dielsiana
#3
Zhonghua Wang, Tongqiang Cai, Xipu He
Millettia dielsiana is a traditional herb medicine to treat rheumatic arthritis and gynecological diseases. In this study, a novel polysaccharide (MDP1) with a molecular weight of 139.54 kDa was isolated from Millettia dielsiana by DEAE-52 cellulose chromatography. Its sulfated derivative (S-MDP1) was prepared by the chlorosulfonic acid-pyridine method. Structural analysis indicated that MDP1 was a pectic polysaccharide and did not exhibit a triple helical conformation. In vitro, MDP1 and S-MDP1 had protective effect on H2 O2 -induced PC12 cells death...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792695/bond-dissociation-energies-of-metallo-supramolecular-building-blocks-insight-from-fragmentation-of-selectively-self-assembled-heterometallic-metallo-supramolecular-aggregates
#4
Yvonne Lorenz, Albert Gutiérrez, Montserrat Ferrer, Marianne Engeser
A series of selectively self-assembled metallo-supramolecular square-like macrocycles with unsymmetric ditopic linkers and two different types of metal corners, i.e., {Pd(η3 -2-Me-C3 H4 )} and {M(dppp)} with dppp = 1,3-bis(diphenylphosphino)propane and M = Pd2+ or Pt2+ , have been studied in the gas phase using collision-induced dissociation. The aggregates show distinct fragmentation patterns determined by ligand length, i.e, aggregate size, and type of metal corner. Information on relative binding strength can be deduced...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792321/explanation-of-dramatic-ph-dependence-of-hydrogen-binding-on-noble-metal-electrode-greatly-weakened-water-adsorption-at-high-ph
#5
Tao Cheng, Lu Wang, Boris V Merinov, William A Goddard
Hydrogen oxidation reaction (HOR) and hydrogen evolution reac-tion (HER) are both two orders slower in alkaline electrolyte than in acidic electrolyte, but no explanation has been provided. The first step towards understanding this dramatic pH-dependent HOR/HER performance is to explain the pH-dependent hydrogen binding to the electrode, a perplexing behavior observed experimentally. In this work, we carried out Quantum Mechanics Molecular Dynam-ics (QMMD) with explicit considerations of solvent and applied voltage (U) to in situ simulate water/Pt (100) interface in the condi-tion of under-potential adsorption of hydrogen (HUPD)...
May 24, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29792104/association-of-hip-and-foot-factors-with-patellar-tendinopathy-jumper-s-knee-in-athletes
#6
Luciana D Mendonça, Juliana M Ocarino, Natália F N Bittencourt, Luciana G Macedo, Sérgio T Fonseca
Study Design Clinical measurement, cross-sectional. Background Investigations on the causes of patellar tendinopathy (PT) should consider impairments at the hip and foot/ankle since they are known to influence movement patterns and affect patellar tendon loading. Objectives To investigate, by means of CART analysis, impairments of the hip and foot/ankle that are associated with PT in volleyball and basketball athletes. Methods One-hundred and ninety athletes were assessed for impairments of the hip and foot/ankle including: shank-forefoot alignment (SFA), ankle dorsiflexion range of motion (DF ROM), iliotibial band flexibility, passive hip internal rotation (IR) ROM, and hip external rotator (ER) and hip abductor isometric strength...
May 23, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29792060/warfarin-monitoring-with-viscoelastic-haemostatic-assays-thrombin-generation-coagulation-factors-and-correlations-to-owren-and-quick-prothrombin-time
#7
Caroline U Nilsson, Karin Strandberg, Peter Reinstrup
The anticoagulant warfarin is commonly monitored with prothrombin time (PT). Viscoelastic haemostatic assays (VHA) are primarily used in situations of acute bleeding to guide haemostatic therapy. Much research has focused on VHA monitoring of new oral anticoagulants. However, many patients are still anticoagulated with warfarin and effect of warfarin anticoagulation on VHA is uncertain. The aim of this study was to assess warfarin anticoagulation on three different VHA and compare these findings with prothrombin time (PT), coagulation factor analyses and a thrombin generation assay (TGA)...
May 23, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29791704/use-of-neuromuscular-electrical-stimulation-during-physical-therapy-may-reduce-the-incidence-of-arthrofibrosis-after-total-knee-arthroplasty
#8
Chukwuweike U Gwam, Tanner McGinnis, Jennifer I Etcheson, Nicole E George, Assem A Sultan, Ronald E Delanois, Anil Bhave, Steven F Harwin, Michael A Mont
INTRODUCTION: Arthrofibrosis remains a major complication following total knee arthroplasty (TKA) that negatively impacts patient outcomes and exhausts healthcare resources. The use of neuromuscular electrical stimulation (NMES) has demonstrated the ability to facilitate quadriceps muscle recovery and reduce pain. Therefore, the purpose of this study was to compare TKA patients who received physical therapy (PT) and adjuvant NMES therapy versus physical therapy alone in terms of: 1) rates of manipulation under anesthesia (MUA) to treat arthrofibrosis; and 2) post-therapy range of motion (ROM)...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791132/ptml-model-of-chembl-data-for-dopamine-targets-docking-synthesis-and-assay-of-new-plg-peptidomimetics
#9
Joana Ferreira da Costa, David Silva, Olga Caamaño, José M Brea, Maria Isabel Loza, Cristian R Munteanu, Alejandro Pazos, Xerardo García-Mera, Humbert González-Díaz
Predicting Drug-Protein Interactions (DPIs) for target proteins involved in Dopamine pathways is very important goal in medicinal chemistry. We can tackle this problem using Molecular Docking or Machine Learning (ML) models for one specific protein. Unfortunately, these models fail to account for large and complex Big Data sets of preclinical assays reported in public databases. This includes multiple conditions of assay like different experimental parameters, biological assays, target proteins, cell lines, organism of the target, organism of assay, etc...
May 23, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29790858/focused-electron-beam-induced-deposition-for-fabrication-of-highly-durable-and-sensitive-metallic-afm-ir-probes
#10
Wen Qian, Shuo Sun, Jingfeng Song, Charles Nguyen, Steven Ducharme, Joseph A Turner
We report on the fabrication of metallic, ultra-sharp atomic force microscope (AFM) tips for localized nanoscale infrared (IR) spectrum measurements by using focused electron-beam-induced deposition of platinum (Pt) or tungsten (W). The tip length can be controlled by changing the duration time of the electron beam. Probes of 12.0 ± 5.0 nm radius-of-curvature can be routinely produced with high repeatability and near-100% yield. The near-field-enhancement appears stronger at the extremity of the metallic tip, compared with commercial pristine silicon nitride (SiN) probe tip...
May 23, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29790548/role-of-flower-like-ultrathin-co-3-o-4-nanosheets-in-water-splitting-and-non-aqueous-li-o-2-batteries
#11
Haitao Wu, Wang Sun, Junrong Shen, David W Rooney, Zhenhua Wang, Kening Sun
The oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) are both fundamental and essential processes for various energy conversion and storage systems. The kinetics of ORR and OER play a critical role in their energy efficiency and practicality. Here, flower-like ultrathin Co3O4 nanosheets synthesized through a facile solvothermal technique were studied as a bifunctional catalyst for both water splitting and non-aqueous Li-O2 batteries. Due to the novel structure and highly active {110} and {100} exposed facets, which can effectively facilitate mass transfer and enhance catalytic capability, Co3O4 nanosheets exhibit better stability and higher ORR/OER activity than Co3O4 nanoparticles, Co3O4 bulks, Pt/C, and RuO2 in alkaline solution...
May 23, 2018: Nanoscale
https://www.readbyqxmd.com/read/29790531/mechanism-of-h-adatoms-improving-the-o-2-reduction-reaction-on-the-zn-modified-anatase-tio-2-101-surface-studied-by-first-principles-calculation
#12
Liangliang Liu, Chongyang Li, Man Jiang, Xiaodong Li, Xiaowei Huang, Zhu Wang, Yu Jia
First principles calculations were performed to cast insight into the mechanism of the improvement of O2 reduction reaction (ORR) activity by Zn and H interstitials on the anatase TiO2 (101) surface. For the Zn-modified anatase TiO2 (101) surface, both surface and subsurface Zn interstitials could contribute to O2 adsorption and dissociation, but the dissociation barriers of O2 molecules are still too high, which limits the ORR activity. After a H adatom is introduced onto the Zn-modified anatase TiO2 (101) surface, the highest energy barriers are greatly reduced compared with those of the Zn-modified surface...
May 23, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29790166/physical-therapy-as-the-first-point-of-care-to-treat-low-back-pain-an-instrumental-variables-approach-to-estimate-impact-on-opioid-prescription-health-care-utilization-and-costs
#13
Bianca K Frogner, Kenneth Harwood, C Holly A Andrilla, Malaika Schwartz, Jesse M Pines
OBJECTIVE: To compare differences in opioid prescription, health care utilization, and costs among patients with low back pain (LBP) who saw a physical therapist (PT) at the first point of care, at any time during the episode or not at all. DATA SOURCES: Commercial health insurance claims data, 2009-2013. STUDY DESIGN: Retrospective analyses using two-stage residual inclusion instrumental variable models to estimate rates for opioid prescriptions, imaging services, emergency department visits, hospitalization, and health care costs...
May 23, 2018: Health Services Research
https://www.readbyqxmd.com/read/29790125/management-of-major-bleeding-and-outcomes-in-patients-treated-with-direct-oral-anticoagulants-results-from-the-start-event-registry
#14
Sophie Testa, Walter Ageno, Emilia Antonucci, Rossella Morandini, Jan Beyer-Westendorf, Maurizio Paciaroni, Marc Righini, Piera Sivera, Peter Verhamme, Vittorio Pengo, Daniela Poli, Gualtiero Palareti
The management of major bleeding in patients treated with direct oral anticoagulants (DOACs) is still not well established. START-Events, a branch of the START registry (Survey on anTicoagulated pAtients RegisTer) (NCT02219984), aims to describe the actual management of bleeding or recurrent thrombotic events in routine clinical practice. We here present the results of the management of bleeding patients. The START-Event registry is a prospective, observational, multicenter, international study. Baseline characteristics (demographic, clinical, risk factors) of patients, laboratory data at admission and during follow-up, site of bleeding, therapeutic strategies, and outcomes at the time of hospital discharge and after 6 months were recorded on a web-based case report form...
May 22, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29789846/macroscopic-and-local-approaches-of-phase-transition-in-sol-gel-synthesized-bi-0-5-na-0-5-tio-3-srtio-3-thin-films
#15
Hyun-Young Lee, Jin Luo, Zhen Zhou, Wei Sun, Jing-Feng Li
High-quality (1 - x)(Bi0.5Na0.5)TiO3-xSrTiO3 lead-free piezoelectric thin films (x = 0, 0.1, and 0.25) on Pt(111)/Ti/SiO2/Si(100) substrates were prepared by a sol-gel method. The microstructures of the thin films as a function of SrTiO3 doping level and temperature were investigated by X-ray diffraction and Raman spectroscopy. Their temperature- and frequency-dependent piezoelectric properties were studied on the nanoscale using switching spectroscopy piezoresponse force microscopy (SS-PFM). A rhombohedral ferroelectric to pseudocubic relaxor phase transition was observed when either ST content or temperature increased...
May 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29789240/effect-of-maternal-immunization-against-pertussis-in-medellin-and-the-metropolitan-area-colombia-2016-2017
#16
Doracelly Hincapié-Palacio, María Cristina Hoyos, Jesus Ochoa, Nilton Montoya, Diego García, Elkin Osorio
BACKGROUND: In 2013, pertussis immunization (Tdap) for pregnant women was implemented in Colombia to protect newborns in response to increased pertussis incidence. OBJECTIVE: To assess the effect of Tdap maternal immunization on the concentration of mother/umbilical cord antibodies and the occurrence of pertussis in infants during their first six months of life. METHODS: A cohort study in eight randomly selected hospitals in Medellin and metropolitan area of Antioquia, Colombia was conducted in 2015-2016...
May 19, 2018: Vaccine
https://www.readbyqxmd.com/read/29789136/penetrating-trauma-in-children-on-the-united-states-mexico-border-hispanic-ethnicity-is-not-a-risk-factor
#17
Loc-Uyen T Vo, Clark Anderson, Samantha Thomas, Hannah Vernia, Jarett K Howe, Alan H Tyroch, Tamara N Fitzgerald
INTRODUCTION: The United States-Mexico border is perceived as dangerous by the media and current political leaders. Hispanic ethnicity, low socioeconomic status, male gender and adolescent age have previously been identified as risk factors for penetrating trauma (PT). METHODS: A retrospective review of PT was performed in a border region. Children 0-17 years old, admitted to the region's only level I trauma center between 2001 and 2016 were included. Standardized morbidity ratio was used to compare observed to expected morbidity...
May 17, 2018: Injury
https://www.readbyqxmd.com/read/29789087/individual-differences-in-adaptability-to-isolated-confined-and-extreme-environments
#18
Paul T Bartone, Gerald P Krueger, Jocelyn V Bartone
INTRODUCTION: Future deep space missions will expose astronauts to more intense stressors than previously encountered. Isolation will be greater and more prolonged, living and work areas more confined, and communications and resupply channels to Earth longer and less reliable. Astronauts will need to function more autonomously, with less guidance and support from Earth. Thus, it is important to select and train astronauts who can adapt and function effectively under extreme and variable conditions...
June 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29788511/training-effects-of-alternated-and-pulsed-currents-on-the-quadriceps-muscles-of-athletes
#19
Pedro Oliveira, Karenina Arrais Guida Modesto, Martim Bottaro, Nicolas Babault, João Luiz Quagliotti Durigan
The aim of the study was to evaluate the effects of 6 weeks training with different neuromuscular electrical stimulation (NMES) currents (medium alternated and low-frequency pulsed current) on muscle architecture and neuromuscular performance of competitive athletes. A double-blind controlled and randomized experimental study was carried out with 33 athletes (22.2±2.6 yrs, 74.7±9.8 kg, 176.8±6.0 cm), divided into 3 groups: mid-frequency current (MF, n=12), pulsed current (PC, n=11) and the control group (CG, n=10)...
May 22, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29787818/pathological-significance-and-prognostic-roles-of-densities-of-cd57-cells-cd68-cells-and-mast-cells-and-their-ratios-in-clear-cell-renal-cell-carcinoma
#20
Hiromi Nakanishi, Yasuyoshi Miyata, Yasushi Mochizuki, Takuji Yasuda, Yuichiro Nakamura, Kyohei Araki, Yuji Sagara, Tomohiro Matsuo, Kojiro Ohba, Hideki Sakai
The immune system is closely associated with malignant behavior in renal cell carcinoma (RCC). Therefore, understanding the pathological roles of immune cells in tumor stroma is essential to discuss the pathological characteristics of RCC. In this study, the clinical significance of densities of CD57+ cells, CD68+ cells, and mast cells, and their ratios were investigated in patients with clear cell RCC. The densities of CD57+, CD68+, and mast cells were evaluated by immunohistochemical techniques in 179 patients...
May 19, 2018: Human Pathology
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