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https://www.readbyqxmd.com/read/27914756/the-colloid-controversy-are-colloids-bad-and-what-are-the-options
#1
REVIEW
Christine Wong, Amie Koenig
Biologic and synthetic colloid solutions are frequently used to increase oncotic pressure and to treat shock. Research has shown that each product has both risks and benefits. Hydroxyethyl starches have gained a reputation for increasing risk of death, acute kidney injury, and coagulation abnormalities in people, but additional studies are needed to see whether these concerns hold true in veterinary patients. This article reviews the risks and benefits of currently available products.
December 1, 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27903244/cryopreservation-of-dermal-fibroblasts-and-keratinocytes-in-hydroxyethyl-starch-based-cryoprotectants
#2
Yahaira Naaldijk, Adiv A Johnson, Annett Friedrich-Stöckigt, Alexandra Stolzing
BACKGROUND: Preservation of human skin fibroblasts and keratinocytes is essential for the creation of skin tissue banks. For successful cryopreservation of cells, selection of an appropriate cryoprotectant agent (CPA) is imperative. The aim of this study was to identify CPAs that minimize toxic effects and allow for the preservation of human fibroblasts and keratinocytes in suspension and in monolayers. RESULTS: We cryopreserved human fibroblasts and keratinocytes with different CPAs and compared them to fresh, unfrozen cells...
December 1, 2016: BMC Biotechnology
https://www.readbyqxmd.com/read/27894390/-effects-of-different-fluid-resuscitation-program-on-renal-function-in-swine-during-shock-stage-of-severe-burn
#3
G L Su, W X Huang, J Chen, D J Xue, J J Zhou
Objective: To explore the effects of different fluid resuscitation program on renal function in swine during shock stage of severe burn. Methods: Twenty-four Guangxi Bama miniature swine were inflicted with 40% total body surface area on the back, and then they were divided into four groups according to the random number table, with 6 swine in each group. At post injury hour (PIH) 2, swine in succinylated gelatin group (S), hydroxyethyl starch group (H), and allogeneic plasma group (A) were respectively resuscitated with succinylated gelatin, hydroxyethyl starch 130/0...
November 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27889336/characterization-of-natural-polymers-from-jackfruit-pulp-calendula-flowers-and-tara-seeds-as-mucoadhesive-and-controlled-release-components-in-buccal-tablets
#4
Vidya Sabale, Archana Paranjape, Vandana Patel, Prafulla Sabale
Identification and physiochemical parameters such as solubility, loss on drying, viscosity, pH, swelling index, starch and gum constituents were determined in natural polymers and showed satisfactory results. Spectral studies established the compatibility of natural polymers. The drug release kinetics in preliminary trial batches showed that tablets containing natural mucilages and gum showed a prolonged drug release comparable to Carbopol 974P and Methocel K4M. Also, all tablets showed a satisfactory drug permeability flux...
November 23, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27882554/study-of-heat-moisture-treatment-of-potato-starch-granules-by-chemical-surface-gelatinization
#5
Josiane Bartz, Elessandra da Rosa Zavareze, Alvaro Renato Guerra Dias
BACKGROUND: Native potato starch was heat-moisture treated (HMT) at 12, 15, 18, 21 and 24 % of moisture content at 110 °C for 1 h and the effects on morphology, structure, thermal and physicochemical properties were investigated. To reveal the internal structure, 30 and 50 % of the granular surface were removed by chemical surface gelatinization in concentrated LiCl solution. RESULTS: At moisture contents of 12 and 15 %, the HTM reduced the gelatinization temperatures and relative crystallinity of the starches while at moisture contents of 21 and 24 % both increased...
November 23, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27882140/hydroxyethyl-starch-resuscitation-downregulate-pro-inflammatory-cytokines-in-the-early-phase-of-severe-acute-pancreatitis-a-retrospective-study
#6
Qi-Jun Chen, Zhi-Yong Yang, Chun-You Wang, Li-Ming Dong, Yu-Shun Zhang, Chao Xie, Chang-Zhong Chen, Shi-Kai Zhu, Hong-Ji Yang, He-Shui Wu, Chong Yang
In the present study, we investigated the effects of hydroxyethyl starch (HES) 130/0.4 on serum pro-inflammatory variables, immunologic variables, fluid balance (FB)-negative(-) rate and renal function in severe acute pancreatitis (SAP) patients. From October, 2007 to November, 2008, a total of 120 SAP patients were enrolled in this retrospective study. Fifty-nine patients in the HES group received 6% HES 130/0.4 combined with crystalloid solution for fluid resuscitation (HES group). In the control group, 61 patients received only crystalloid solution after admission...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27872985/pharmacokinetics-and-histopathological-findings-of-chemoembolization-using-cisplatin-powder-mixed-with-degradable-starch-microspheres-in-a-rabbit-liver-tumor-model
#7
Takeshi Sato, Toshihiro Tanaka, Hideyuki Nishiofuku, Yasushi Fukuoka, Hiroshi Sakaguchi, Tetsuya Masada, Shota Tatsumoto, Nagaaki Marugami, Masato Takano, Ichiro Yamato, Masayuki Sho, Chiho Ohbayashi, Toshiko Hirai, Kimihiko Kichikawa
PURPOSE: The purpose of this study is to evaluate the pharmacokinetics and histopathological findings of transarterial chemoembolization (TACE) using cisplatin powder mixed with degradable starch microspheres (DSM) (Cis/DSM-TACE) compared with cisplatin arterial infusion (Cis-AI). MATERIALS AND METHODS: Eighteen rabbits with VX2 liver tumors were divided into two groups: Cis/DSM-TACE (n = 9) and Cis-AI (n = 9) groups. In the Cis/DSM-TACE group, a mixture of cisplatin powder and DSM was injected until stasis of hepatic arterial flow was achieved...
November 21, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27853795/formation-and-relaxation-kinetics-of-starch-particle-complexes
#8
Frida Iselau, Tuan Phan Xuan, Gregor Trefalt, Aleksandar Matic, Krister Holmberg, Romain Bordes
The formation and relaxation kinetics of starch-particle complexes were investigated in this study. The combination of cationic nanoparticles in suspension and anionic starch in solution gave rise to aggregate formation which was studied by dynamic light scattering, revealing the initial adsorption of the starch molecules on the particle surface. By examining the stability ratio, W, it was found that even in the most destabilized state, i.e. at charge neutralization, the starch chains had induced steric stabilization to the system...
November 17, 2016: Soft Matter
https://www.readbyqxmd.com/read/27816752/reduced-intake-of-carbohydrate-prevents-the-development-of-obesity-and-impaired-glucose-metabolism-in-ghrelin-o-acyltransferase-knockout-mice
#9
Tetsuya Kouno, Nobuteru Akiyama, Kumiko Fujieda, Isamu Nanchi, Tomohiko Okuda, Takanori Iwasaki, Shogo Oka, Hideo Yukioka
A close relationship between acylated-ghrelin and sucrose intake has been reported. However, little has been examined about the physiological action of ghrelin on preference for different types of carbohydrate such as glucose, fructose, and starch. The current study was aimed to investigate the role of acylated-ghrelin in the determinants of the choice of carbohydrates, and pathogenesis of chronic disorders, including obesity and insulin resistance. In a two-bottle-drinking test, ghrelin O-acyltransferase (GOAT) knockout (KO) mice consumed a less amount of glucose and maltodextrin, and almost the same amount of fructose and saccharin solution compared to WT littermates...
December 2016: Peptides
https://www.readbyqxmd.com/read/27781270/the-effects-of-entanglement-concentration-on-the-hydrodynamic-properties-of-cereal-starches
#10
Li Guo, Juanjuan Zhang, Jian Hu, Xianfeng Du, Bo Cui
BACKGROUND: The hydrodynamic properties of four cereal starches in dilute and semi-dilute aqueous solutions were investigated using a Ubbelohde viscometer, a transmission electron microscope and steady shear rheological measurements. RESULTS: The results indicated that the starch solutions showed the non-linear shape of the ηsp /c versus c curves in dilute solutions, followed by a linear increase to different extents thereafter. The intrinsic viscosity might be positively correlated with the entanglement concentration (ce )...
October 26, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27779578/does-small-volume-resuscitation-with-crystalloids-or-colloids-influence-hemostasis-and-survival-of-rabbits-subjected-to-lethal-uncontrolled-hemorrhage
#11
Bijan S Kheirabadi, Nahir Miranda, Irasema B Terrazas, Mary D Gonzales, Rose C Grimm, Michael A Dubick
INTRODUCTION: Prehospital, small-volume resuscitation of combat casualties with a synthetic colloid [6% hydroxyethyl starch (HES) 670/0.75] has been recommended when blood or blood components are unavailable. We studied hemostatic effects of a newer synthetic colloid (6% HES 130/0.4,) compared to either a natural colloid (albumin) or to crystalloids in an uncontrolled hemorrhage model. METHODS: Spontaneously breathing NZW rabbits (3.4±0.1 kg) were anesthetized, instrumented and subjected to a splenic injury with uncontrolled bleeding...
October 25, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27767972/erythrocyte-interactions-comparison-of%C3%A2-the%C3%A2-aggregation-power-of-polymer-molecules-used-in-medicine-not-only-size%C3%A2-does-matter
#12
S Jovtchev, S Alexandrov, N Hristova-Avakumova, S Miteva, L Traikov, D Gerasimova, S Stoeff
BACKGROUND: Different colloids are used as a part of solutions for fluid resuscitation and organ preservation: hydroxyethyl starches (HES), dextran (Dx), polyethylene glycols (PEG), polyvinyl pyrrolidone (PVP). Some of the problems associated with their application are addressed to alteration in erythrocyte (ERY) rheology. OBJECTIVE: We intended to estimate in vitro and compare the aggregation power (AP) of these molecules related to ERY interactions. METHODS: Washed human ERY are used during the study...
October 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27753568/compatibility-of-hydroxyethyl-starch-and-tranexamic-acid-for-battlefield-co-administration
#13
Nicholas M Studer, Ahmad H Yassin, Donald E Keen
INTRODUCTION: The current Tactical Combat Casualty Care Guidelines recommend tranexamic acid (TXA) administration for casualties in whom massive blood transfusion is anticipated. However, despite Hextend being the recommended resuscitation fluid, the guidelines recommend against using TXA with Hextend. This appears to be due to a concern about pharmaceutical compatibility, despite the absence of a direct study of compatibility in the literature. METHODS: Two solutions of Hextend and TXA were examined for compatibility...
October 2016: Military Medicine
https://www.readbyqxmd.com/read/27747968/perioperative-intravenous-fluid-therapy-in-children-guidelines-from-the-association-of-the-scientific-medical-societies-in-germany
#14
Robert Sümpelmann, Karin Becke, Sebastian Brenner, Christian Breschan, Christoph Eich, Claudia Höhne, Martin Jöhr, Franz-Josef Kretz, Gernot Marx, Lars Pape, Markus Schreiber, Jochen Strauss, Markus Weiss
This consensus- based S1 Guideline for perioperative infusion therapy in children is focused on safety and efficacy. The objective is to maintain or re-establish the child's normal physiological state (normovolemia, normal tissue perfusion, normal metabolic function, normal acid- base- electrolyte status). Therefore, the perioperative fasting times should be as short as possible to prevent patient discomfort, dehydration, and ketoacidosis. A physiologically composed balanced isotonic electrolyte solution (BS) with 1-2...
October 17, 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27746354/preparation-and-characteristic-of-gelatine-oxidized-corn-starch-and-gelatin-corn-starch-blend-microspheres
#15
Hui Chen, Zhi Hua Shan, Meng Wai Woo, Xiao Dong Chen
Combinations of gelatin (G) and oxidized corn starch (OCS) were explored as a new microcapsule composite for single droplet spray drying. The blending solutions property, gel time, transparency and viscosity of G/CS (corn starch) and G/OCS blend solutions were compared at different ratios (10:0;9:1;8:2;7:3;6:4;5:5) and concentrations(1%wt; 3%wt; 5%wt). The drying and dissolution behaviors of composite droplet have been studied using the single droplet drying technique. Possible reaction mechanisms in the composite blend were elucidated by SEM and FTIR techniques...
October 13, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27738483/comparison-of-the-effectiveness-of-hydroxyethyl-starch-voluven-solution-with-normal-saline-in-hemorrhagic-shock-treatment-in-trauma
#16
Kambiz Masoumi, Arash Forouzan, Ali Asgari Darian, Alireza Rafaty Navaii
BACKGROUND: Appropriate fluid therapy affects morbidity and mortality rates. A conclusion is yet to be reached on the role of crystalloids and colloids in immediate fluid therapy. This study was done to determine the suitable solution in immediate resuscitation of patients with hemorrhagic shock caused by tissue trauma. METHODS: One hundred trauma patients with hemorrhagic shock, who underwent fluid therapy in the emergency unit, were assigned randomly to two groups of hydroxyethyl starch (Voluven) and normal saline...
November 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27733678/direct-characterization-of-the-maize-starch-synthase-iia-product-shows-maltodextrin-elongation-occurs-at-the-non-reducing-end
#17
Mark E Larson, Daniel J Falconer, Alan M Myers, Adam W Barb
A comprehensive description of starch biosynthesis and granule assembly remains undefined despite the central nature of starch as an energy storage molecule in plants and as a fundamental calorie source for many animals. Multiple theories regarding the starch synthase (SS)-catalyzed assembly of (α1-4)-linked d-glucose molecules into maltodextrins generally agree that elongation occurs at the non-reducing terminus based on the degradation of radiolabeled maltodextrins, although recent reports challenge this hypothesis...
November 25, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27722659/solubility-of-starch-and-microcrystalline-cellulose-in-1-ethyl-3-methylimidazolium-acetate-ionic-liquid-and-solution-rheological-properties
#18
Xiaoyan Tan, Xiaoxi Li, Ling Chen, Fengwei Xie
This study compared the solubility of starch (G50) and microcrystalline cellulose (MCC) in an ionic liquid (IL), 1-ethyl-3-methylimidazolium acetate ([Emim][OAc]), at different temperatures. From SAXS and WAXS analysis, polysaccharides could be totally dissolved in [Emim][OAc]. Fourier-transform infrared (FTIR) spectra showed a similar dissolution mechanism for starch and MCC, which was related to the formation of hydrogen bonds between polysaccharide hydroxyls and acetic anions, causing the breakage of the hydrogen bonding network of the polysaccharide...
October 5, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27719887/intelligent-ph-indicator-film-composed-of-agar-potato-starch-and-anthocyanin-extracts-from-purple-sweet-potato
#19
Inyoung Choi, Jun Young Lee, Monique Lacroix, Jaejoon Han
A new colorimetric pH indicator film was developed using agar, potato starch, and natural dyes extracted from purple sweet potato, Ipomoea batatas. Both agar and potato starch are solid matrices used to immobilize natural dyes, anthocyanins. The ultraviolet-visible (UV-vis) spectrum of anthocyanin extract solutions and agar/potato starch films with anthocyanins showed color variations to different pH values (pH 2.0-10.0). Fourier transform infrared (FT-IR) and UV-vis region spectra showed compatibility between agar, starch, and anthocyanin extracts...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27712013/an-in-vitro-comparison-of-the-effects-of-voluven-6-hydroxyethyl-starch-130-0-4-and-hespan-6-hydroxyethyl-starch-670-0-75-on-measures-of-blood-coagulation-in-canine-blood
#20
Michelle Griego-Valles, Yekaterina Buriko, Jennifer E Prittie, Philip R Fox
OBJECTIVE: To assess primary and secondary hemostasis following in vitro dilution of canine whole blood (WB) with hydroxyethyl starch (HES) 130/0.4 and HES 670/0.75. DESIGN: In vitro experimental study. SETTING: Private practice, teaching hospital. ANIMALS: Twenty-five healthy dogs. INTERVENTIONS: Each dog underwent venipuncture and 18 mL of venous blood was sampled once. MEASUREMENTS AND MAIN RESULTS: Collected blood was separated in 4 aliquots...
October 6, 2016: Journal of Veterinary Emergency and Critical Care
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