keyword
https://read.qxmd.com/read/38536807/turkish-cultural-adaptation-validity-and-reliability-of-the-stroke-activity-scale-in-individuals-with-hemiparesis
#1
JOURNAL ARTICLE
Ayşe Göktaş, Volkan Türkmen, Fulya Damla Çolak, Gamze Ekici
AIM: The aim of this study was to make the Turkish cultural adaptation of the the Stroke Activity Scale (SAS). METHOD: This study was designed as a methodological research. The psychometric properties of the SAS scale were evaluated by validity and reliability analyses. RESULTS: The average age of 84 stroke patients (mean ± SD) was 59.52 ± 14.03 years. Kaiser-Meyer-Olkin (0.816) and Bartlett's Test of Sphericity (χ2 = 288...
March 27, 2024: Topics in Stroke Rehabilitation
https://read.qxmd.com/read/38536167/risk-assessment-and-prevention-of-falls-in-older-community-dwelling-adults-a-review
#2
JOURNAL ARTICLE
Cathleen S Colón-Emeric, Cara L McDermott, Deborah S Lee, Sarah D Berry
IMPORTANCE: Falls are reported by more than 14 million US adults aged 65 years or older annually and can result in substantial morbidity, mortality, and health care expenditures. OBSERVATIONS: Falls result from age-related physiologic changes compounded by multiple intrinsic and extrinsic risk factors. Major modifiable risk factors among community-dwelling older adults include gait and balance disorders, orthostatic hypotension, sensory impairment, medications, and environmental hazards...
March 27, 2024: JAMA
https://read.qxmd.com/read/38535326/reproductive-enhancement-through-phytochemical-characteristics-and-biological-activities-of-date-palm-pollen-a-comprehensive-review-on-potential-mechanism-pathways
#3
REVIEW
Saad Salhi, Abdellatif Rahim, Mouad Chentouf, Hasnaa Harrak, Jean Loup Bister, Naima Hamidallah, Bouchra El Amiri
Infertility represents a significant global health challenge affecting both men and women. Despite regular unprotected sexual intercourse, approximately 15% of couples of reproductive age struggle to conceive within 12 months, with 10% of infertility cases attributed to unknown causes worldwide. As a result, numerous studies have turned their attention to exploring the use of natural products for the prevention and treatment of infertility. Among these natural remedies is date palm pollen (DPP), a male reproductive powder derived from the blossoms of the Phoenix dactylifera L...
March 14, 2024: Metabolites
https://read.qxmd.com/read/38534735/microbial-based-bioactive-compounds-to-alleviate-inflammation-in-obesity
#4
REVIEW
Oladayo Emmanuel Apalowo, Grace Adeola Adegoye, Tolulope Mobolaji Obuotor
The increased prevalence of obesity with several other metabolic disorders, including diabetes and non-alcoholic fatty liver disease, has reached global pandemic proportions. Lifestyle changes may result in a persistent positive energy balance, hastening the onset of these age-related disorders and consequently leading to a diminished lifespan. Although suggestions have been raised on the possible link between obesity and the gut microbiota, progress has been hampered due to the extensive diversity and complexities of the gut microbiota...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534413/-enterobacteriaceae-in-the-human-gut-dynamics-and-ecological-roles-in-health-and-disease
#5
REVIEW
Maria Ines Moreira de Gouveia, Annick Bernalier-Donadille, Gregory Jubelin
The human gut microbiota plays a crucial role in maintaining host health. Our review explores the prevalence and dynamics of Enterobacteriaceae , a bacterial family within the Proteobacteria phylum, in the human gut which represents a small fraction of the gut microbiota in healthy conditions. Even though their roles are not yet fully understood, Enterobacteriaceae and especially Escherichia coli ( E. coli ) play a part in creating an anaerobic environment, producing vitamins and protecting against pathogenic infections...
February 23, 2024: Biology
https://read.qxmd.com/read/38533972/heart-rate-variability-deceleration-capacity-of-heart-rate-and-death-a-veteran-twins-study
#6
JOURNAL ARTICLE
Minxuan Huang, Amit J Shah, Rachel Lampert, Donald L Bliwise, Dayna A Johnson, Gari D Clifford, Richard Sloan, Jack Goldberg, Yi-An Ko, Giulia Da Poian, Erick A Perez-Alday, Zakaria Almuwaqqat, Anish Shah, Mariana Garcia, An Young, Kasra Moazzami, J Douglas Bremner, Viola Vaccarino
BACKGROUND: Autonomic function can be measured noninvasively using heart rate variability (HRV), which indexes overall sympathovagal balance. Deceleration capacity (DC) of heart rate is a more specific metric of vagal modulation. Higher values of these measures have been associated with reduced mortality risk primarily in patients with cardiovascular disease, but their significance in community samples is less clear. METHODS AND RESULTS: This prospective twin study followed 501 members from the VET (Vietnam Era Twin) registry...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533894/long-term-intake-of-thermo-induced-oxidized-oil-results-in-anxiety-like-and-depression-like-behaviors-involvement-of-microglia-and-astrocytes
#7
JOURNAL ARTICLE
Meishan Lu, Jiachen Shi, Xue Li, Yanjun Liu, Yuanfa Liu
Frequent consumption of fried foods has been strongly associated with a higher risk of anxiety and depression, particularly among young individuals. The existing evidence has indicated that acrylamide produced from starchy foods at high temperatures can induce anxious behavior. However, there is limited research on the nerve damage caused by thermo-induced oxidized oil (TIOO). In this study, we conducted behavioral tests on mice and found that prolonged consumption of TIOO led to significant anxiety behavior and a tendency toward depression...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38532789/the-effect-of-reward-on-motor-learning-different-stage-different-effect
#8
REVIEW
Jingwang Zhao, Guanghu Zhang, Dongsheng Xu
Motor learning is a prominent and extensively studied subject in rehabilitation following various types of neurological disorders. Motor repair and rehabilitation often extend over months and years post-injury with a slow pace of recovery, particularly affecting the fine movements of the distal extremities. This extended period can diminish the motivation and persistence of patients, a facet that has historically been overlooked in motor learning until recent years. Reward, including monetary compensation, social praise, video gaming, music, and virtual reality, is currently garnering heightened attention for its potential to enhance motor motivation and improve function...
2024: Frontiers in Human Neuroscience
https://read.qxmd.com/read/38532534/unilateral-magnetic-resonance-imaging-guided-laser-interstitial-thermal-therapy-thalamotomy-for-essential-tremor
#9
JOURNAL ARTICLE
Mickael Aubignat, Mélissa Tir, Martial Ouendo, Salem Boussida, Jean-Marc Constans, Michel Lefranc
BACKGROUND: Essential tremor (ET) affects numerous adults, impacting quality of life (QOL) and often defying pharmacological treatment. Surgical interventions like deep brain stimulation (DBS) and lesional approaches, including radiofrequency, gamma-knife radiosurgery, and magnetic resonance imaging (MRI)-guided focused ultrasound, offer solutions but are not devoid of limitations. OBJECTIVES: This retrospective, single-center, single-blinded pilot study aimed to assess the safety and efficacy of unilateral MRI-guided laser interstitial thermal therapy (MRIg-LITT) thalamotomy for medically intractable ET...
March 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38532458/a-phase-ii-study-of-belumosudil-for-chronic-graft-versus-host-disease-in-patients-who-failed-at-least-one-line-of-systemic-therapy-in-china
#10
JOURNAL ARTICLE
Ying Wang, Depei Wu, Xiang Zhang, Yuhua Li, Yanjie He, Qifa Liu, Li Xuan, Zhenyu Li, Kunming Qi, Yuqian Sun, Shunqing Wang, Wenjian Mo, Lei Gao, Ye Hua, Yu Wang, Ying Zhang
BACKGROUND: Chronic graft-versus-host disease (cGVHD) is an immune-related disorder that is the most common complication post-allogenic hematopoietic stem cell transplant. Corticosteroids with or without calcineurin inhibitors (CNIs) remain the mainstay of cGVHD treatment for first-line therapy. However, for many patients, cGVHD symptoms cannot be effectively managed and thus require second-line therapy. Currently, there is no approved treatment for second-line cGVHD treatment in China...
March 26, 2024: BMC Medicine
https://read.qxmd.com/read/38531632/deletion-of-the-clock-gene-bmal2-leads-to-alterations-in-hypothalamic-clocks-circadian-regulation-of-feeding-and-energy-balance
#11
JOURNAL ARTICLE
Rosana Dantas-Ferreira, Dominique Ciocca, Patrick Vuillez, Stéphanie Dumont, Christian Boitard, Ute C Rogner, Etienne Challet
BMAL2 (ARNTL2) is a paralog of BMAL1 that can form heterodimers with the other circadian factors CLOCK and NPAS2 to activate transcription of clock and clock-controlled genes. To assess a possible role of Bmal2 in the circadian regulation of metabolism, we investigated daily variations of energy metabolism, feeding behavior, and locomotor behavior, as well as ability to anticipate restricted food access in male mice knock-out for Bmal2 (B2KO). While their amount of food intake and locomotor activity were normal compared to wild-type mice, B2KO mice displayed increased adiposity (1...
March 26, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38529859/-possibilities-of-%C3%A2-therapeutic-retargeting%C3%A2-of-3-hydroxypyridine-and-succinic-acid-derivatives-due-to-their-dopaminergic-action
#12
JOURNAL ARTICLE
I A Volchegorskii, L M Rassokhina, I U Miroshnichenko
The review is devoted to a comparative analysis of the clinical efficacy of the original domestic derivatives of 3-hydroxypyridine and succinic acid (emoxipine, reamberin and mexidol) in comparison with the results of an experimental study of their dopaminergic action. The position that the dopaminomimetic activity of emoxipin, reamberin and mexidol largely determines their anti-ischemic, antihypoxic, insulin-potentiating neuroprotective, nootropic and antidepressant potential has been substantiated. A comparative analysis of the safety profile of emoxipine, reamberin and mexidol was carried out, taking into account potential and real side-effects caused by iatrogenic deviations from the eudopaminergic state...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38529532/large-scale-animal-model-study-uncovers-altered-brain-ph-and-lactate-levels-as-a-transdiagnostic-endophenotype-of-neuropsychiatric-disorders-involving-cognitive-impairment
#13
JOURNAL ARTICLE
Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth G N Grant, Michiru Ida-Eto, Masaaki Narita, Ken-Ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa
Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicated in patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed in five mouse models of schizophrenia, bipolar disorder, and autism, suggesting a shared endophenotype among these disorders rather than mere artifacts due to medications or agonal state...
March 26, 2024: ELife
https://read.qxmd.com/read/38529309/effectiveness-of-therapeutic-ultrasound-on-reducing-pain-intensity-and-functional-disability-in-patients-with-plantar-fasciitis-a-systematic-review-of-randomised-controlled-trials
#14
JOURNAL ARTICLE
Anas Mohammed Alhakami, Reem Abdullah Babkair, Ahmad Sahely, Shibili Nuhmani
BACKGROUND: Ultrasound therapy is one of the preferred conservative treatments for patients with plantar fasciitis. This study aims to evaluate the effectiveness of therapeutic ultrasound in decreasing pain intensity and improving functional disability in patients with plantar fasciitis. METHODS: Five randomised control trials (RCT) were selected based on an electronic search in PubMed, Trip Database and PEDro. To be included in the systematic review, the study should be an RCT which investigated the effectiveness of therapeutic ultrasound conducted in patients with plantar fasciitis with pain intensity and functional disability as outcome measures...
2024: PeerJ
https://read.qxmd.com/read/38529039/therapeutic-potential-to-target-sialylation-and-siglecs-in-neurodegenerative-and-psychiatric-diseases
#15
REVIEW
Jannis Wißfeld, Tawfik Abou Assale, German Cuevas-Rios, Huan Liao, Harald Neumann
Sialic acids, commonly found as the terminal carbohydrate on the glycocalyx of mammalian cells, are pivotal checkpoint inhibitors of the innate immune system, particularly within the central nervous system (CNS). Sialic acid-binding immunoglobulin-like lectins (SIGLECs) expressed on microglia are key players in maintaining microglial homeostasis by recognizing intact sialylation. The finely balanced sialic acid-SIGLEC system ensures the prevention of excessive and detrimental immune responses in the CNS. However, loss of sialylation and SIGLEC receptor dysfunctions contribute to several chronic CNS diseases...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38529019/theater-practice-and-interpersonal-synchronization-behaviors-a-pilot-study-comparing-actors-and-non-actors
#16
JOURNAL ARTICLE
Gabriele Sofia, Clément Mager, Lionel Brunel, Anne-Sophie Noel
Recent studies in the field of theater studies no longer view theater as an object, but rather as a dynamic relationship between actors and spectators. In an embodied and situated perspective of cognition, imagination emerges as a product of this dynamic. This study aims to investigate whether acting practice enhances someone's abilities to set up an effective relationship with others and allows the individual to better manage not only the relationship itself, but also her/his own feelings and those of her/his partner...
2024: Frontiers in Human Neuroscience
https://read.qxmd.com/read/38527899/molybdenum-and-cadmium-co-induce-necroptosis-through-th1-th2-imbalance-mediated-endoplasmic-reticulum-stress-in-duck-ovaries
#17
JOURNAL ARTICLE
Ting Cui, Xueyan Dai, Huiling Guo, Dianyun Wang, Bingyan Huang, Wenjing Pu, Xuesheng Chu, Caiying Zhang
Cadmium (Cd) and excess molybdenum (Mo) pose serious threats to animal health. Our previous study has determined that Cd and/or Mo exposure can cause ovarian damage of ducks, while the specific mechanism is still obscure. To further investigate the toxic mechanism of Cd and Mo co-exposure in the ovary, forty 8-day-old female ducks were randomly allocated into four groups for 16 weeks, and the doses of Cd and Mo in basic diet per kg were as follows: control group, Mo group (100 mg Mo), Cd group (4 mg Cd), and Mo + Cd group (100 mg Mo + 4 mg Cd)...
August 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/38527891/enhanced-hepatic-metabolic-perturbation-of-polystyrene-nanoplastics-by-uv-irradiation-induced-hydroxyl-radical-generation
#18
JOURNAL ARTICLE
Shiyu He, Jingran Wang, Lihong Zhou, Zhen Mao, Xiaodan Zhang, Jin Cai, Peili Huang
The environmental behavior of and risks associated with nanoplastics (NPs) have attracted considerable attention. However, compared to pristine NPs, environmental factors such as ultraviolet (UV) irradiation that lead to changes in the toxicity of NPs have rarely been studied. We evaluated the changes in morphology and physicochemical properties of polystyrene (PS) NPs before and after UV irradiation, and compared their hepatotoxicity in mice. The results showed that UV irradiation caused particle size reduction and increased the carbonyl index (CI) and negative charge on the particle surface...
August 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/38527275/development-and-validation-of-the-bilingual-catalan-spanish-cross-cultural-adaptation-of-the-consensus-auditory-perceptual-evaluation-of-voice
#19
JOURNAL ARTICLE
Neus Calaf, David Garcia-Quintana
PURPOSE: This study aimed to develop a valid and reliable bilingual version of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) for the auditory-perceptual evaluation of voice in Catalan and Spanish speakers. METHOD: The development of this CAPE-V adaptation included Delphi methodology with 20 voice and speech experts reaching consensus on the optimal adapted terminology of the perceptual vocal attributes, considering also input from the original instrument authors...
March 25, 2024: Journal of Speech, Language, and Hearing Research: JSLHR
https://read.qxmd.com/read/38526883/assessment-of-sensorized-insoles-in-balance-and-gait-in-individuals-with-parkinson-s-disease
#20
JOURNAL ARTICLE
A Pergolini, T Bowman, T Lencioni, A Marzegan, M Meloni, M C Carrozza, E Trigili, N Vitiello, D Cattaneo, S Crea
Individuals with Parkinson's disease (PD) are characterized by gait and balance disorders limiting their independence and quality of life. Home-based rehabilitation programs, combined with drug therapy, demonstrated to be beneficial in the daily-life activities of PD subjects. Sensorized shoes can extract balance- and gait-related data in home-based scenarios and allow clinicians to monitor subjects' activities. In this study, we verified the capability of a pair of sensorized shoes (including pressure-sensitive insoles and one inertial measurement unit) in assessing ground-level walking and body weight shift exercises...
March 25, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
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