keyword
https://read.qxmd.com/read/38535348/the-effects-of-temperature-on-the-development-and-survival-of-bathycoelia-distincta-hemiptera-pentatomidae-a-significant-pest-of-macadamia-in-south-africa
#1
JOURNAL ARTICLE
Mulalo M Muluvhahothe, Elsje Joubert, Stefan H Foord
Temperature is the most influential condition affecting insect development and population dynamics. Understanding its impact and other important factors, such as diet, could provide fine-scale predictions of species abundance and distribution in space and time. The two-spotted stink bug, Bathycoelia distincta Distant (Hemiptera: Pentatomidae), is a significant pest of macadamia in South Africa for which limited information on developmental biology exists. Here, for the first time, variations in key developmental parameters of the B...
February 23, 2024: Insects
https://read.qxmd.com/read/38533573/joubert-syndrome-presenting-with-levodopa-responsive-parkinsonism
#2
JOURNAL ARTICLE
Jin Hwangbo, Ki-Seok Park, Hyun Sung Kim, Jae-Hwan Choi, Jae-Hyeok Lee
No abstract text is available yet for this article.
March 27, 2024: Journal of Movement Disorders
https://read.qxmd.com/read/38527243/anti-iglon5-disease-with-inaugural-bilateral-neuropapillitis
#3
JOURNAL ARTICLE
Sarah Demortiere, Bastien Joubert, Marie Benaiteau, Frederic Hilezian, Clemence Boutiere, Audrey Rico, Natacha Stolowy, Valerie Dubois, Bertrand Audoin, Adil Maarouf, Jean Pelletier
No abstract text is available yet for this article.
April 23, 2024: Neurology
https://read.qxmd.com/read/38521583/observing-g4-formation-and-its-resolution-by-pif1-in-real-time-by-manipulation-under-magnetic-tweezers
#4
JOURNAL ARTICLE
Jessica Valle-Orero, Martin Rieu, Jean-François Allemand, Dulamkhuu Bujaa, Alexandra Joubert, Phong Lan Thao Tran, Vincent Croquette, Jean-Baptiste Boulé
G-quadruplexes (G4s) are nucleic acids secondary structures that may form in guanine-rich sequences, either intra or inter-molecularly. Ability of a primary sequence to form a G4 can be predicted computationally with an improving accuracy as well as tested in bulk using biophysical measurements. As a result, G4 density maps have been devised for a large number of genomes from all life kingdoms. Experimental validation of the formation of G4s in vivo however remains indirect and relies on their stabilization with small molecules, antibodies or proteins, or mutational studies, in order to measure downstream effects on gene expression or genome stability for example...
2024: Methods in Enzymology
https://read.qxmd.com/read/38519817/a-high-threshold-of-biotherapeutic-aggregate-numbers-is-needed-to-induce-an-immunogenic-response-in-vitro-in-vivo-and-in-the-clinic
#5
JOURNAL ARTICLE
Joseph R Cohen, Stephen R Brych, Siddharth Prabhu, Vivian Bi, Ahmed Elbaradei, Joshua M Tokuda, Cathie Xiang, Martha Hokom, Xiaohong Cui, Claudia Ly, Nathan Amos, Jilin Sun, Dominador Calamba, Jonathan Herskovitz, Allyson Capili, Kimya Nourbakhsh, Anthony Merlo, Julia Carreon, Jette Wypych, Linda O Narhi, Vibha Jawa, Marisa K Joubert
BACKGROUND AND PURPOSE: There is concern that subvisible aggregates in biotherapeutic drug products pose a risk to patient safety. We investigated the threshold of biotherapeutic aggregates needed to induce immunogenic responses. METHODS AND RESULTS: Highly aggregated samples were tested in cell-based assays and induced cellular responses in a manner that depended on the number of particles. The threshold of immune activation varied by disease state (cancer, rheumatoid arthritis, allergy), concomitant therapies, and particle number...
March 22, 2024: Pharmaceutical Research
https://read.qxmd.com/read/38513236/a-human-immunodeficiency-virus-superinfection-diagnosed-in-a-patient-on-intramuscular-long-acting-combination-of-cabotegravir-and-rilpivirine
#6
JOURNAL ARTICLE
Nadia Valin, Sidonie Lambert-Niclot, Emma Torres, Jean Luc Meynard, Claire Périllaud-Dubois, Laurence Morand-Joubert, Karine Lacombe
A case of a male with human immunodeficiency virus with plasma genotyping detecting no resistance and a CRF02_AG subtype had a controlled HIV RNA on antiretroviral therapy since 2010. We introduced intramuscular therapy with cabotegravir and rilpivirine. One month later, his HIV RNA was 1500 copies/mL; genotyping found a subtype B with many mutations.
March 21, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38510388/-but-this-is-the-new-reality-and-i-will-adapt-understanding-lecturers-experiences-of-covid-19-lockdown-online-learning-and-teaching
#7
JOURNAL ARTICLE
Lynette J van der Merwe, Sanet van Zyl, Gina Joubert
Following the 2020 COVID-19 pandemic national lockdown in South Africa, the University of the Free State launched various support initiatives for academic staff and students. Teaching and learning activities and assessments were adapted for emergency remote teaching. Students and academic staff members experienced disruption due to the migration to the online environment. This study aimed to investigate the experiences of academic staff members in an undergraduate medical programme using a mixed-methods approach in the form of a sequential exploratory design in two phases...
February 2024: Medical Science Educator
https://read.qxmd.com/read/38508515/the-iaslc-lung-cancer-staging-project-recommendation-to-introduce-spread-through-air-spaces-stas-as-a-histologic-descriptor-in-the-9-th-edition-of-the-tnm-classification-of-lung-cancer-analysis-of-4-061-pathologic-stage-i-non-small-cell-lung-carcinomas
#8
JOURNAL ARTICLE
William D Travis, Megan Eisele, Katherine K Nishimura, Rania Aly, Pietro Bertoglio, Teh-Ying Chou, Frank C Detterbeck, Jessica Donnington, Wentao Fang, Philippe Joubert, Kemp Kernstine, Young Tae Kim, Yolande Lievens, Hui Liu, Gustavo Lyons, Mari Mino-Kenudson, Andrew G Nicholson, Mauro Papotti, Ramon Rami-Porta, Valerie Rusch, Shuji Sakai, Paula Ugalde, Paul Van Schil, Jeff Yang, Vanessa J Cilento, Masaya Yotsukura, Hisao Asamura
Spread through air spaces (STAS) consists of lung cancer tumor cells that are identified beyond the edge of the main tumor in the surrounding alveolar parenchyma. It has been reported by meta-analyses to be an independent prognostic factor in the major histologic types of lung cancer, but its role in lung cancer staging is not established. To assess the clinical importance of STAS in lung cancer staging, we evaluated 4061 surgically resected pathologic Stage I R0 nonsmall cell carcinomas (NSCLC) collected from around the world in the IASLC database...
March 18, 2024: Journal of Thoracic Oncology
https://read.qxmd.com/read/38504136/fine-tuning-fam161a-gene-augmentation-therapy-to-restore-retinal-function
#9
JOURNAL ARTICLE
Yvan Arsenijevic, Ning Chang, Olivier Mercey, Younes El Fersioui, Hanna Koskiniemi-Kuendig, Caroline Joubert, Alexis-Pierre Bemelmans, Carlo Rivolta, Eyal Banin, Dror Sharon, Paul Guichard, Virginie Hamel, Corinne Kostic
For 15 years, gene therapy has been viewed as a beacon of hope for inherited retinal diseases. Many preclinical investigations have centered around vectors with maximal gene expression capabilities, yet despite efficient gene transfer, minimal physiological improvements have been observed in various ciliopathies. Retinitis pigmentosa-type 28 (RP28) is the consequence of bi-allelic null mutations in the FAM161A, an essential protein for the structure of the photoreceptor connecting cilium (CC). In its absence, cilia become disorganized, leading to outer segment collapses and vision impairment...
March 19, 2024: EMBO Molecular Medicine
https://read.qxmd.com/read/38502237/joubert-syndrome-derived-induced-pluripotent-stem-cells-show-altered-neuronal-differentiation-in-vitro
#10
JOURNAL ARTICLE
Roberta De Mori, Silvia Tardivo, Lidia Pollara, Silvia Clara Giliani, Eltahir Ali, Lucio Giordano, Vincenzo Leuzzi, Rita Fischetto, Blanca Gener, Santo Diprima, Marco J Morelli, Maria Cristina Monti, Virginie Sottile, Enza Maria Valente
Joubert syndrome (JS) is a recessively inherited congenital ataxia characterized by hypotonia, psychomotor delay, abnormal ocular movements, intellectual disability, and a peculiar cerebellar and brainstem malformation, the "molar tooth sign." Over 40 causative genes have been reported, all encoding for proteins implicated in the structure or functioning of the primary cilium, a subcellular organelle widely present in embryonic and adult tissues. In this paper, we developed an in vitro neuronal differentiation model using patient-derived induced pluripotent stem cells (iPSCs), to evaluate possible neurodevelopmental defects in JS...
March 19, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38494470/dysautonomia-in-anti-hu-paraneoplastic-neurological-syndromes
#11
JOURNAL ARTICLE
Macarena Villagrán-García, Antonio Farina, Joaquín Arzalluz-Luque, Lucia Campetella, Sergio Muñiz-Castrillo, Marie Benaiteau, Elise Peter, Pauline Dumez, Valentin Wucher, Maroua Dhairi, Géraldine Picard, Marie Rafiq, Dimitri Psimaras, Véronique Rogemond, Bastien Joubert, Jérôme Honnorat
BACKGROUND AND OBJECTIVES: Dysautonomia has been associated with paraneoplastic neurological syndrome (PNS)-related mortality in anti-Hu PNS, but its frequency and spectrum remain ill-defined. We describe anti-Hu patients with dysautonomia, estimate its frequency, and compare them to patients without dysautonomia. METHODS: Patients with anti-Hu antibodies diagnosed in the study centre (1990-2022) were retrospectively reviewed; those with autonomic signs and symptoms were identified...
March 17, 2024: Journal of Neurology
https://read.qxmd.com/read/38490881/familial-and-social-implications-of-breast-and-gynaecological-cancer-in-kerala-india
#12
JOURNAL ARTICLE
Lorane Scaria, Saju Madavanakadu Devassy, Lynette Joubert
BACKGROUND: Due to the paucity of reliable data to determine the components of family-based comprehensive care for cancer in India, we explored the familial implications of gynaecological and breast cancer diagnosis and treatment through a mixed-method study. METHODS: The mixed method study included 130 women aged above 18 with a confirmed diagnosis of gynaecological or breast cancer recruited from three selected tertiary hospitals in Kerala, India. Information on quality of life (36-Item Short Form Survey (SF-36)), psychological distress (distress thermometer), and the familial, interpersonal, social, and community impacts of cancer (semi-structured interview guide) were elicited...
March 14, 2024: Current Problems in Cancer
https://read.qxmd.com/read/38484041/successful-introgression-of-wmel-wolbachia-into-aedes-aegypti-populations-in-fiji-vanuatu-and-kiribati
#13
JOURNAL ARTICLE
Cameron P Simmons, Wesley Donald, Lekon Tagavi, Len Tarivonda, Timothy Quai, Raynelyn Tavoa, Tebikau Noran, Erirau Manikaoti, Lavinia Kareaua, Tabomoa Tinte Abwai, Dip Chand, Vineshwaran Rama, Vimal Deo, Kharishma Karti Deo, Aminiasi Tavuii, Wame Valentine, Ravi Prasad, Eremasi Seru, Leikitah Naituku, Anaseini Ratu, Mark Hesketh, Nichola Kenny, Sarah C Beebe, Anjali A Goundar, Andrew McCaw, Molly Buntine, Ben Green, Tibor Frossard, Jeremie R L Gilles, D Albert Joubert, Geoff Wilson, Le Quyen Duong, Jean B Bouvier, Darren Stanford, Carolyn Forder, Johanna M Duyvestyn, Etiene C Pacidônio, Heather A Flores, Natalie Wittmeier, Kate Retzki, Peter A Ryan, Jai A Denton, Ruth Smithyman, Stephanie K Tanamas, Peter Kyrylos, Yi Dong, Anam Khalid, Lauren Hodgson, Katherine L Anders, Scott L O'Neill
Pacific Island countries have experienced periodic dengue, chikungunya and Zika outbreaks for decades. The prevention and control of these mosquito-borne diseases rely heavily on control of Aedes aegypti mosquitoes, which in most settings are the primary vector. Introgression of the intracellular bacterium Wolbachia pipientis (wMel strain) into Ae. aegypti populations reduces their vector competence and consequently lowers dengue incidence in the human population. Here we describe successful area-wide deployments of wMel-infected Ae...
March 14, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38483130/central-nervous-system-adverse-events-of-immune-checkpoint-inhibitors
#14
JOURNAL ARTICLE
Antonio Farina, Macarena Villagrán-García, Alberto Vogrig, Bastien Joubert
PURPOSE OF REVIEW: Immune checkpoint inhibitors (ICI) may trigger immune-related adverse events which rarely affect the central nervous system (CNS-irAEs). Over the past few years, cumulative data have led to the characterization of well defined syndromes with distinct cancer and antibody associations as well as different outcomes. RECENT FINDINGS: The most frequent CNS-irAE is encephalitis, which includes three main groups: meningoencephalitis, a nonfocal syndrome usually responsive to corticosteroids; limbic encephalitis, associated with high-risk paraneoplastic neurological syndromes (PNS) antibodies (e...
March 15, 2024: Current Opinion in Neurology
https://read.qxmd.com/read/38467790/neurological-autoimmunity-in-melanoma-patients-a-comparison-between-those-exposed-and-non-exposed-to-immune-checkpoint-inhibitors
#15
JOURNAL ARTICLE
Andreu Vilaseca, Antonio Farina, Macarena Villagrán-García, Antoine Pegat, Marie Benaiteau, Nicolás Lundahl Ciano-Petersen, Le-Duy Do, Véronique Rogemond, David Gonçalves, Dimitri Psimaras, Cristina Birzu, Jérôme Honnorat, Bastien Joubert
BACKGROUND: The clinical spectrum of melanoma-associated neurological autoimmunity, whether melanoma-associated paraneoplastic neurological syndromes (PNS) or induced by immune checkpoint inhibitors (ICI), is not well characterized. We aim to describe the clinical spectrum of melanoma-associated neurological autoimmunity. METHODS: A systematic review of the literature combined with patients from French databases of paraneoplastic neurological syndromes was conducted...
March 11, 2024: Journal of Neurology
https://read.qxmd.com/read/38450697/small-bowel-metastasis-from-embryonal-rhabdomyosarcoma-of-the-extremity-a-case-report
#16
JOURNAL ARTICLE
P Joubert, M Mihalik
Rhabdomyosarcoma is the most common soft tissue tumour in children and adolescents, but extremely rare in adults with comparatively worse outcomes. Metastatic disease is not uncommon, but intra-abdominal metastases are exceedingly rare. We report an unusual case of ileal metastases from an upper extremity rhabdomyosarcoma in a 17-year-old male who presented with abdominal pain during a routine follow-up visit. Laparotomy and ileocecectomy for a perforated ileal mass confirmed metastatic embryonal rhabdomyosarcoma with 1 out of 14 positive lymph node metastases...
November 2023: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://read.qxmd.com/read/38437987/carbohydrate-counting-knowledge-and-ambulatory-glucose-profile-in-persons-living-with-type-1-diabetes
#17
JOURNAL ARTICLE
Sopio Tatulashvili, Bleuenn Dreves, Laurent Meyer, Emmanuel Cosson, Michael Joubert
UNLABELLED: Context The amount of consumed carbohydrates is the strongest factor influencing glucose levels during the four hours following a meal. Our aim was to evaluate the association between carbohydrate counting knowledge and continuous glucose monitoring (CGM) parameters in patients with type 1 diabetes (T1D) using different insulin regimens. METHOD: In this multicenter prospective study, the GluciQuizz questionnaire was used to evaluate carbohydrate knowledge...
March 2, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38428424/structurally-divergent-and-recurrently-mutated-regions-of-primate-genomes
#18
JOURNAL ARTICLE
Yafei Mao, William T Harvey, David Porubsky, Katherine M Munson, Kendra Hoekzema, Alexandra P Lewis, Peter A Audano, Allison Rozanski, Xiangyu Yang, Shilong Zhang, DongAhn Yoo, David S Gordon, Tyler Fair, Xiaoxi Wei, Glennis A Logsdon, Marina Haukness, Philip C Dishuck, Hyeonsoo Jeong, Ricardo Del Rosario, Vanessa L Bauer, Will T Fattor, Gregory K Wilkerson, Yuxiang Mao, Yongyong Shi, Qiang Sun, Qing Lu, Benedict Paten, Trygve E Bakken, Alex A Pollen, Guoping Feng, Sara L Sawyer, Wesley C Warren, Lucia Carbone, Evan E Eichler
We sequenced and assembled using multiple long-read sequencing technologies the genomes of chimpanzee, bonobo, gorilla, orangutan, gibbon, macaque, owl monkey, and marmoset. We identified 1,338,997 lineage-specific fixed structural variants (SVs) disrupting 1,561 protein-coding genes and 136,932 regulatory elements, including the most complete set of human-specific fixed differences. We estimate that 819.47 Mbp or ∼27% of the genome has been affected by SVs across primate evolution. We identify 1,607 structurally divergent regions wherein recurrent structural variation contributes to creating SV hotspots where genes are recurrently lost (e...
February 23, 2024: Cell
https://read.qxmd.com/read/38412472/variant-functional-assessment-in-drosophila-by-overexpression-what-can-we-learn
#19
JOURNAL ARTICLE
Yina Her, Danielle M Pascual, Zoe Goldstone-Joubert, Paul C Marcogliese
The last decade has been highlighted by the increased use of next-generation DNA sequencing technology to identify novel human disease genes. A critical downstream part of this process is assigning function to a candidate gene variant. Functional studies in Drosophila melanogaster, the common fruit fly, have made a prominent contribution in annotating variant impact in an in vivo system. The use of patient-derived knock-in flies or rescue-based, "humanization", approaches are novel and valuable strategies in variant testing but have been recently widely reviewed...
February 27, 2024: Genome Génome / Conseil National de Recherches Canada
https://read.qxmd.com/read/38411380/pediatric-asthma-therapy-assessment-questionnaire-for-the-brazilian-population-cross-cultural-adaptation-and-measurement-properties
#20
JOURNAL ARTICLE
Thayla Amorim Santino, Hesli de Sousa Holanda, Juliana Cirilo Soares de Souza, Maria Clara Almeida Jácome, Fernanda Elizabeth Pereira da Silva Menescal, Joubert Vitor de Souto Barbosa, Ada Cristina Jácome, Cleia Teixeira do Amaral, João Carlos Alchieri, Karla Morganna Pereira Pinto de Mendonça
OBJECTIVE: To cross-culturally adapt the Pediatric Asthma Therapy Assessment Questionnaire (ATAQ) into Brazilian Portuguese and analyze its measurement properties. METHODS: This exploratory methodological study included eight experts and 30 caregivers in the translation and cross-cultural adaptation steps. Thereafter, 118 caregivers of pediatric patients with asthma aged between 5 and 17 years were involved in the analysis of measurement properties. We analyzed the content, structural (exploratory and confirmatory factorial), construct (convergent and discriminant), and known-groups validities; floor and ceiling effects; and determined the cut-off point (receiver operator characteristic curve) to identify pediatric patients with uncontrolled asthma...
February 27, 2024: Pediatric Pulmonology
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