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https://www.readbyqxmd.com/read/29672318/a-novel-2-methoxyestradiol-analogue-is-responsible-for-vesicle-disruption-and-lysosome-aggregation-in-breast-cancer-cells
#1
Sandra D Nkandeu, Iman van den Bout, Marianne J Cronjé, Dirk H van Papendorp, Anna M Joubert
BACKGROUND: 2-Methoxyestradiol (2ME2) is an endogenous metabolite of 17-β-estradiol with anti-proliferative and anti-angiogenic properties. Due to 2ME2's rapid metabolism and low oral bioavailability in in vivo settings, 2ME2 analogues have been designed to alleviate these issues. One of these compounds is 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16). A previous work alluded to the ability of ESE-16 to induce autophagic cell death. Therefore, we investigated the mode of action of ESE-16 by studying its effects on autophagy, vesicle formation, and lysosomal organisation...
April 19, 2018: Pharmacology
https://www.readbyqxmd.com/read/29669906/cortical-and-subcortical-gray-matter-bases-of-cognitive-deficits-in-rem-sleep-behavior-disorder
#2
Shady Rahayel, Ronald B Postuma, Jacques Montplaisir, Daphné Génier Marchand, Frédérique Escudier, Malo Gaubert, Pierre-Alexandre Bourgouin, Julie Carrier, Oury Monchi, Sven Joubert, Frédéric Blanc, Jean-François Gagnon
OBJECTIVE: To investigate cortical and subcortical gray matter abnormalities underlying cognitive impairment in patients with REM sleep behavior disorder (RBD) with or without mild cognitive impairment (MCI). METHODS: Fifty-two patients with RBD, including 17 patients with MCI, were recruited and compared to 41 controls. All participants underwent extensive clinical assessments, neuropsychological examination, and 3-tesla MRI acquisition of T1 anatomical images...
April 18, 2018: Neurology
https://www.readbyqxmd.com/read/29663881/recent-developments-in-drug-design-of-no-donor-hybrid-compounds
#3
Sarel Francois Malan, Rajan Sharma, Jacques Joubert
The free radical nitric oxide (NO) is considered one of the most versatile endogenous molecules and is a crucial signalling molecule in numerous biochemistry pathways of the human body. NO is directly related to pathological processes and plays an important role in many different and interrelated physiological processes. In some cases, a depletion of NO or an attenuation of its effector system could exist as in hypertension, angina and impotence; in others, an overproduction of NO may be a major cause of damage, as in circulatory shock, sepsis, neurodegenerative disorders and inflammatory responses...
April 16, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29662843/insulinotropic-effect-of-s-allyl-cysteine-in-rat-pups
#4
Busisani W Lembede, Jeanette Joubert, Pilani Nkomozepi, Kennedy H Erlwanger, Eliton Chivandi
S -Allyl cysteine (SAC) is found in garlic and has been reported to exert antidiabetic and antiobesity properties in drug-induced adult experimental models of metabolic dysfunction, but its potential beneficial effects in high-fructose diet neonatal rat models have not been determined. This study investigated the potential prophylactic effects of SAC in high-fructose diet fed suckling rat pups modelling human neonates fed a high-fructose diet. Four-day-old male (n=32) and female (n=32) Wistar rat pups, were randomly assigned to and administered the following treatment regimens daily for 15 days: group I, distilled water; group II, 20% fructose solution (FS); group III, SAC; group IV, SAC+FS...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29652866/optimizing-the-energy-and-throughput-of-a-water-quality-monitoring-system
#5
Segun O Olatinwo, Trudi-H Joubert
This work presents a new approach to the maximization of energy and throughput in a wireless sensor network (WSN), with the intention of applying the approach to water-quality monitoring. Water-quality monitoring using WSN technology has become an interesting research area. Energy scarcity is a critical issue that plagues the widespread deployment of WSN systems. Different power supplies, harvesting energy from sustainable sources, have been explored. However, when energy-efficient models are not put in place, energy harvesting based WSN systems may experience an unstable energy supply, resulting in an interruption in communication, and low system throughput...
April 13, 2018: Sensors
https://www.readbyqxmd.com/read/29642759/cannabis-use-and-knowledge-among-medical-students-at-the-university-of-the-free-state-bloemfontein-south-africa
#6
Roshini Jain, Ch Chiech Chang, Mpho A Koto, Alden N Geldenhuys, Richard J Nichol, Gina Joubert
OBJECTIVE: The study aimed to investigate the prevalence of cannabis use among undergraduate medical students of the University of the Free State (UFS), and the extent of their knowledge about the substance. METHOD: This cross-sectional study included five year groups of undergraduate medical students. A self-administered, anonymous questionnaire was used. RESULTS: Of the 643 medical students, 541 (84.1%) completed the questionnaire. In total, 161 (30...
April 11, 2018: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/29626554/physical-activity-and-dual-disease-burden-among-south-african-primary-schoolchildren-from-disadvantaged-neighbourhoods
#7
Markus Gerber, Ivan Müller, Cheryl Walter, Rosa du Randt, Larissa Adams, Stefanie Gall, Nandi Joubert, Siphesihle Nqweniso, Danielle Smith, Peter Steinmann, Nicole Probst-Hensch, Jürg Utzinger, Uwe Pühse
People from low- and middle-income countries still face challenges stemming from parasitic infections. Additionally, non-communicable diseases (NCDs) and their risk factors are rapidly increasing, which puts South African children at an elevated risk of a dual disease burden, with negative consequences for child development and wellbeing. Contrastingly, regular physical activity (PA) is associated with decreased cardiovascular disease (CVD) risk. Therefore, the objective of this study was to examine whether PA is associated with the double infection-CVD phenotype burden in South African schoolchildren...
April 4, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29605658/novel-mutations-in-the-ciliopathy-associated-gene-cplane1-c5orf42-cause-ofd-syndrome-type-vi-rather-than-joubert-syndrome
#8
Carine Bonnard, Mohammad Shboul, Seyed Hassan Tonekaboni, Alvin Yu Jin Ng, Sumanty Tohari, Kakaly Ghosh, Angeline Lai, Jiin Ying Lim, Ene Choo Tan, Louise Devisme, Morgane Stichelbout, Adila Alkindi, Nazreen Banu, Zafer Yüksel, Jamal Ghoumid, Nadia Elkhartoufi, Lucile Boutaud, Alessia Micalizzi, Maggie Siewyan Brett, Byrappa Venkatesh, Enza Maria Valente, Tania Attié-Bitach, Bruno Reversade, Ariana Kariminejad
Mutations in CPLANE1 (previously known as C5orf42) cause Oral-Facial-Digital Syndrome type VI (OFD6) as well as milder Joubert syndrome (JS) phenotypes. Seven new cases from five unrelated families diagnosed with pure OFD6 were systematically examined. Based on the clinical manifestations of these patients and those described in the literature, we revised the diagnostic features of OFD6 and include the seven most common characteristics: 1) molar tooth sign, 2) tongue hamartoma and/or lobulated tongue, 3) additional frenula, 4) mesoaxial polydactyly of hands, 5) preaxial polydactyly of feet, 6) syndactyly and/or bifid toe, and 7) hypothalamic hamartoma...
March 29, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29592971/the-joubert-syndrome-protein-arl13b-binds-tubulin-to-maintain-uniform-distribution-of-proteins-along-the-ciliary-membrane
#9
Ekaterina Revenkova, Qing Liu, G Luca Gusella, Carlo Iomini
Cilia-mediated signal transduction involves precise targeting and localization of selected molecules along the ciliary membrane. However, the molecular mechanism underlying these events is unclear. The Joubert syndrome protein ARL13B is a membrane-associated G-protein that localizes along the cilium and functions in protein transport and signaling. We identify tubulin as a direct interactor of ARL13B and demonstrate that the association occurs via the G-domain and independently from ARL13B's GTPase activity...
March 28, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29590458/muscular-disorder-related-to-immune-checkpoint-inhibitors-forewarned-is-forearmed
#10
Laure Gallay, Julie Bourgeois-Vionnet, Bastien Joubert, Nathalie Streichenberger, Arnaud Hot
No abstract text is available yet for this article.
March 24, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29584910/week-96-efficacy-of-lopinavir-ritonavir-monotherapy-in-virologically-suppressed-patients-with-hiv-a-randomized-non-inferiority-trial-anrs-140-dream
#11
Jean-Luc Meynard, Laetitia Moinot, Roland Landman, Laurence Morand-Joubert, Amel Besseghir, Sami Kolta, Bruno Spire, Eve Todesco, Olivier Bouchaud, Catherine Fagard, Geneviève Chene, Pierre-Marie Girard
Background: Sparing of antiretroviral drug classes could reduce the toxicity and cost of maintenance treatment for HIV infection. Objectives: To evaluate the non-inferiority of efficacy and the safety of lopinavir/ritonavir (r) monotherapy versus a single-tablet regimen of efavirenz, emtricitabine and tenofovir (EFV/FTC/TDF) over 2 years. Methods: Adults on stable ART with plasma HIV-1 RNA viral load <50 copies/mL for the past 12 months and no documented treatment failure were randomized to receive either lopinavir/r or EFV/FTC/TDF for 2 years...
March 23, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29568536/cerebellar-cognitive-affective-syndrome-insights-from-joubert-syndrome
#12
Chelsea L Hickey, Janet C Sherman, Paula Goldenberg, Amy Kritzer, Paul Caruso, Jeremy D Schmahmann, Mary K Colvin
Background: Joubert syndrome (JS) is a rare, autosomal recessively inherited genetic disorder characterized morphologically by unique developmental malformations of the cerebellum and brainstem (the molar tooth sign), and clinically by impaired motor functions and intellectual disability. Patients with JS often face multiple cognitive challenges, but the neuropsychological profile of this condition has not been well characterized. Methods: We performed comprehensive neurological and neuropsychological evaluations in three adult brothers with JS, ages 32, 27, and 25 years...
2018: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/29568313/the-in-vitro-effects-of-a-novel-estradiol-analog-on-cell-proliferation-and-morphology-in-human-epithelial-cervical-carcinoma
#13
Laura Susan Boyd, Devrim Gozuacik, Anna Margaretha Joubert
Background: The majority of novel chemotherapeutics target the cell cycle, aiming to effect arrest and cause apoptosis. One such agent, 2-methoxyestradiol (2ME), has been shown to possess anticancer properties against numerous cancer types, both in vitro and in vivo. Despite its promise, 2ME has exhibited limitations, including low oral bioavailability and rapid hepatic enzymatic inactivation in vivo. A novel sulphamoylated estrogen analog, 2-ethyl-3- O -sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16), was in silico-designed in our laboratory to overcome these issues...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29566517/variational-nonadiabatic-dynamics-in-the-moving-crude-adiabatic-representation-further-merging-of-nuclear-dynamics-and-electronic-structure
#14
Loïc Joubert-Doriol, Artur F Izmaylov
A new methodology of simulating nonadiabatic dynamics using frozen-width Gaussian wavepackets within the moving crude adiabatic representation with the on-the-fly evaluation of electronic structure is presented. The main feature of the new approach is the elimination of any global or local model representation of electronic potential energy surfaces; instead, the electron-nuclear interaction is treated explicitly using the Gaussian integration. As a result, the new scheme does not introduce any uncontrolled approximations...
March 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29559277/adamantane-amine-linked-chloroquinoline-derivatives-as-chloroquine-resistance-modulating-agents-in-plasmodium-falciparum
#15
Opute M Yvette, Sarel F Malan, Dale Taylor, Erika Kapp, Jacques Joubert
Previously we have shown that pentacycloundecylamine-chloroquinoline (PCU-CQ) conjugates possess significant chemosensitizing abilities and can circumvent the resistance associated with chloroquine (CQ) resistant plasmodia. In order to further explore structurally related polycyclic compounds as reversed CQ agents we synthesized a series of eight aza-adamantanol (1-4) and adamantane-imine (5-8) CQ conjugates. All conjugates showed limited cytotoxicity against CHO cells (IC50  > 37 µM). Compounds 1, 2 and 5 were highly active (K1 IC50  < 100 nM) exhibiting a 3-4-fold increase in antiplasmodial activity against CQ resistant strain K1 compared to CQ...
March 12, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29556062/androgen-receptor-modulation-following-combination-exposure-to-brominated-flame-retardants
#16
Joubert Banjop Kharlyngdoh, Ajay Pradhan, Per-Erik Olsson
Endocrine disrupting compounds can interfere with androgen receptor (AR) signaling and disrupt steroidogenesis leading to reproductive failure. The brominated flame-retardant (BFR) 1, 2-dibromo-4-(1, 2-dibromoethyl) cyclohexane (TBECH), is an agonist to human, chicken and zebrafish AR. Recently another group of alternative BFRs, allyl 2, 4, 6-tribromophenyl ether (ATE), and 2, 3-dibromopropyl 2, 4, 6-tribromophenyl ether (DPTE) along with its metabolite 2-bromoallyl 2, 4, 6-tribromophenyl ether (BATE) were identified as potent human AR antagonists...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29553717/impact-of-site-specific-conjugation-of-scfv-to-multifunctional-nanomedicines-using-second-generation-maleimide
#17
Katel Herve-Aubert, Emilie Allard-Vannier, Nicolas Joubert, Zineb Lakhrif, Christophe Alric, Camille Martin, Marie-Claude Viaud-Massuard, Isabelle Dimier-Poisson, Nicolas Aubrey, Igor Chourpa
Biocompatible multifunctional nanomedicines (NMs) are known to be an attractive platform for targeted anticancer theranosis. However, these nanomedicines have an interest only if they efficiently target diseased cells and accumulate in tumors. Here we report the synthesis of a new generation of immunotargeted nanomedicines composed of a superparamagnetic iron oxide nanoparticle (SPION) core, polyethylene glycol coating and the anti-HER2 single chain fragment variable (scFv) of Trastuzumab antibody. We developed two novel bioengineered scFv carrying two cysteines located (i) at the end (4D5...
March 19, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29547942/leveraging-lung-tissue-transcriptome-to-uncover-candidate-causal-genes-in-copd-genetic-associations
#18
Maxime Lamontagne, Jean-Christophe Bérubé, Ma'en Obeidat, Michael H Cho, Brian D Hobbs, Phuwanat Sakornsakolpat, Kim de Jong, H Marike Boezen, David Nickle, Ke Hao, Wim Timens, Maarten van den Berge, Philippe Joubert, Michel Laviolette, Don D Sin, Peter D Paré, Yohan Bossé
Causal genes of chronic obstructive pulmonary disease (COPD) remain elusive. The current study aims at integrating genome-wide association studies (GWAS) and lung expression quantitative loci (eQTL) data to map COPD candidate causal genes and gain biological insights into the recently discovered COPD susceptibility loci. Two complementary genomic datasets on COPD were studied. First, the lung eQTL dataset which included whole-genome gene expression and genotyping data from 1,038 individuals. Second, the largest COPD GWAS to date from the International COPD Genetics Consortium (ICGC) with 13,710 cases and 38,062 controls...
March 14, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29547447/an-acute-bout-of-aquatic-treadmill-exercise-induces-greater-improvements-in-endothelial-function-and-post-exercise-hypotension-than-land-treadmill-exercise-a-crossover-study
#19
Dustin P Joubert, Jorge Z Granados, Jonathan M Oliver, Bethany L Noack, Peter W Grandjean, Christopher R Woodman, Steven E Riechman, Stephen F Crouse
OBJECTIVE: The purpose of the study was to compare acute bouts of aquatic treadmill (ATM) and land treadmill (LTM) exercise on flow-mediated dilation (FMD), post-exercise blood pressure (BP), plasma nitrate/nitrite (PN), and atrial natriuretic peptide (ANP) in untrained, pre-hypertensive men. DESIGN: In a counterbalanced, crossover design, 19 untrained, pre-hypertensive men completed bouts of ATM and LTM on separate days. FMD was measured pre-exercise and 1-hour post-exercise...
March 15, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29518159/correction-the-sulfated-laminarin-triggers-a-stress-transcriptome-before-priming-the-sa-and-ros-dependent-defenses-during-grapevine-s-induced-resistance-against-plasmopara-viticola
#20
Adrien Gauthier, Sophie Trouvelot, Jani Kelloniemi, Patrick Frettinger, David Wendehenne, Xavier Daire, Jean-Marie Joubert, Alberto Ferrarini, Massimo Delledonne, Victor Flors, Benoit Poinssot
[This corrects the article DOI: 10.1371/journal.pone.0088145.].
2018: PloS One
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