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Brian Webster, Scott W Werneke, Biljana Zafirova, Sébastien This, Séverin Coléon, Elodie Décembre, Helena Paidassi, Isabelle Bouvier, Pierre-Emmanuel Joubert, Darragh Duffy, Thierry Walzer, Matthew L Albert, Marlène Dreux
Type I interferon (IFN-I) responses are critical for the control of RNA virus infections, however, many viruses, including Dengue (DENV) and Chikungunya (CHIKV) virus, do not directly activate plasmacytoid dendritic cells (pDCs), robust IFN-I producing cells. Herein, we demonstrated that DENV and CHIKV infected cells are sensed by pDCs, indirectly, resulting in selective IRF7 activation and IFN-I production, in the absence of other inflammatory cytokine responses. To elucidate pDC immunomodulatory functions, we developed a mouse model in which IRF7 signaling is restricted to pDC...
June 19, 2018: ELife
Valentin Joubert, Virginie Silvestre, Mathilde Grand, Denis Loquet, Virginie Ladroue, Fabrice Besacier, Serge Akoka, Gerald Stanislas Remaud
For the last ten years, quantitative isotope ratio monitoring 13C NMR (irm-13C NMR) has been successfully tested and proved as an efficient tool for the determination of the position-specific determination of 13C/12C ratios. Several applications in different domains have shown its interest. In the context of origin assignment, the possibility to track the distribution network of illicit drugs or cutting agents is of prime importance. However irm-13C NMR still suffers from a relative lack of sensitivity limiting its dissemination among control laboratories...
June 18, 2018: Analytical Chemistry
Johan W Joubert
This article presents the procedure followed to generate complete synthetic populations from the South African National Census. The populations are accurate at both household and individual level, and were generated for nine major metropolitan and provincial areas. The disaggregate description of the population is useful in a variety of modelling contexts, especially if one wants to observe or study the distributional effects of, for example, policy measures. That is, studies in which equity and equality are of concern...
August 2018: Data in Brief
Bastien Joubert, Kevin Rostásy, Jérôme Honnorat
Immune-mediated cerebellar ataxia (CA) comprises a group of rare diseases that are still incompletely described, and are probably underdiagnosed. Both acute and progressive progressions are possible. Different syndromes have been identified, including CA associated with anti-GAD antibodies, the cerebellar type of Hashimoto encephalopathy, primary autoimmune CA, gluten ataxia, opsoclonus-myoclonus syndrome, and paraneoplastic cerebellar degenerations. Most of these syndromes are associated with autoantibodies targeting neuronal antigens...
2018: Handbook of Clinical Neurology
Sandrine Tury, Franck Assayag, Florian Bonin, Sophie Chateau-Joubert, Jean-Luc Servely, Sophie Vacher, Véronique Becette, Martial Caly, Audrey Rapinat, David Gentien, Pierre de la Grange, Anne Schnitzler, François Lallemand, Elisabetta Marangoni, Ivan Bièche, Céline Callens
To ensure their high proliferation rate, tumor cells display an iron metabolic disorder with increased iron needs, making them more susceptible to iron deprivation. This vulnerability could be a therapeutic target. In breast cancers, the development of new therapeutic approaches is urgently needed for patients with triple negative tumors which frequently relapse after chemotherapy and suffer from a lack of targeted therapies. In this work, we demonstrated that deferasirox (DFX) synergizes with standard chemotherapeutic agents such as with doxorubicin, cisplatin and carboplatin to inhibit cell proliferation and induce apoptosis and autophagy in triple-negative breast cancer (TNBC) cell lines...
June 7, 2018: Journal of Pathology
T Nguyen, D B Fofana, M P Lê, C Charpentier, G Peytavin, M Wirden, S Lambert-Niclot, N Desire, M Grude, L Morand-Joubert, P Flandre, C Katlama, D Descamps, V Calvez, E Todesco, A G Marcelin
Background: Integrase strand transfer inhibitors (INSTIs) are recommended by international guidelines as first-line therapy in antiretroviral-naive and -experienced HIV-1-infected patients. Objectives: This study aimed at evaluating the prevalence at failure of INSTI-resistant variants and the impact of baseline minority resistant variants (MiRVs) on the virological response to an INSTI-based regimen. Methods: Samples at failure of 134 patients failing a raltegravir-containing (n = 65), an elvitegravir-containing (n = 20) or a dolutegravir-containing (n = 49) regimen were sequenced by Sanger sequencing and ultra-deep sequencing (UDS)...
June 4, 2018: Journal of Antimicrobial Chemotherapy
Yves Reznik, Aklilu Habteab, Javier Castaneda, John Shin, Michael Joubert
AIMS: The relative contribution of basal hyperglycemia (BHG) and postprandial hyperglycemia (PPHG) in type 2 diabetes patients treated with multiple daily injections (MDI) of insulin is poorly documented. In this study, the BHG and PPHG of OpT2mise patients initially treated with MDI were assessed before randomization and after 6 months of continuous subcutaneous insulin infusion (CSII). MATERIALS AND METHODS: Blinded Continuous Glucose Monitoring (CGM) data were collected in 259 MDI patients after completion of an 8-week run-in period...
June 4, 2018: Diabetes, Obesity & Metabolism
Nimesh Joseph, Caezar Al-Jassar, Christopher M Johnson, Antonina Andreeva, Deepak D Barnabas, Stefan M V Freund, Fanni Gergely, Mark van Breugel
Ciliopathies are a group of genetic disorders caused by a failure to form functional cilia. Due to a lack of structural information, it is currently poorly understood how ciliopathic mutations affect protein functionality to give rise to the underlying disease. Using X-ray crystallography, we show that the ciliopathy-associated centriolar protein CEP120 contains three C2 domains. The point mutations V194A and A199P, which cause Joubert syndrome (JS) and Jeune asphyxiating thoracic dystrophy (JATD), respectively, both reduce the thermostability of the second C2 domain by targeting residues that point toward its hydrophobic core...
May 29, 2018: Cell Reports
Jessica Pineault, Pierre Jolicoeur, Stephan Grimault, Patrick Bermudez, Simona Maria Brambati, Jacinthe Lacombe, Juan Manuel Villalpando, Marie-Jeanne Kergoat, Sven Joubert
OBJECTIVE: Semantic memory impairment has been documented in individuals with amnestic Mild cognitive impairment (aMCI), who are at risk of developing Alzheimer's disease (AD), yet little is known about the neural basis of this breakdown. The aim of this study was to investigate the brain mechanisms associated with semantic performance in aMCI patients. METHOD: A group of aMCI patients and a group of healthy controls carried out a semantic categorization task while their brain activity was recorded using magnetoencephalography (MEG)...
May 2018: Neuropsychology
Quentin Giraud, Julio Gonçalvès, Benoît Paris, Antoine Joubert, Stéfan Colombano, David Cazaux
Remediation of dense non-aqueous phase liquids (DNAPLs) represents a challenging issue because of their persistent behaviour in the environment. This pilot-scale study investigates, by means of in situ experiments and numerical modelling, the feasibility of the pulsed pumping process of a large amount of a DNAPL in an alluvial aquifer. The main compound of the DNAPL is hexachlorobutadiene (HCBD), added in 2015 to the persistent organic pollutants list (POP). A low-permeability keyed enclosure was built at the location of the DNAPL source zone in order to isolate a finite volume of soil and a 3-month pulsed pumping process was applied inside the enclosure to exclusively extract the DNAPL...
May 23, 2018: Journal of Contaminant Hydrology
Els Visser, David Edholm, B Mark Smithers, Iain G Thomson, Bryan H Burmeister, Euan T Walpole, David C Gotley, Warren L Joubert, Victoria Atkinson, Tao Mai, Janine M Thomas, Andrew P Barbour
BACKGROUND: The optimal treatment strategy for patients with esophageal adenocarcinoma (EAC) remains undetermined. This study compared outcomes in patients undergoing neoadjuvant chemotherapy (nCT) and neoadjuvant chemoradiotherapy (nCRT) for EAC. METHODS: Patients who underwent nCT or nCRT followed by surgery for EAC were identified from a prospective database (2000-2017) and included. After propensity score matching, the impact of the treatments on postoperative complications, in-hospital mortality, pathological outcomes, and survival rates were compared...
May 28, 2018: Journal of Surgical Oncology
Clément Portois, Elyess Essouayed, Michael D Annable, Nathalie Guiserix, Antoine Joubert, Olivier Atteia
A novel approach using foam to manage hazardous waste was successfully demonstrated under active site conditions. The purpose of the foam was to divert groundwater flow, that would normally enter the source zone area, to reduce dissolved contaminant release to the aquifer. During the demonstration, foam was pre generated and directly injected surrounding the chlorinated solvent source zone. Despite the constraints related to the industrial activities and non-optimal position of the injection points, the applicability and effectiveness of the approach have been highlighted using multiple metrics...
May 1, 2018: Journal of Contaminant Hydrology
Caroline Spasojevic, Elisabetta Marangoni, Sophie Vacher, Franck Assayag, Didier Meseure, Sophie Château-Joubert, Martine Humbert, Manale Karam, Jean Marc Ricort, Christian Auclair, Marie Regairaz, Ivan Bièche
Protein Kinase D1 (PKD1) is a serine/threonine kinase encoded by the PRKD1 gene. PKD1 has been previously shown to be a prognostic factor in ERα+ tamoxifen-resistant breast tumors and PKD1 overexpression confers estrogen independence to ERα+ MCF7 cells. In the present study, our goal was to determine whether PKD1 is a prognostic factor and/or a relevant therapeutic target in breast cancer. We analyzed PRKD1 mRNA levels in 527 primary breast tumors. We found that high PRKD1 mRNA levels were significantly and independently associated with a low metastasis-free survival in the whole breast cancer population and in the triple-negative breast cancer (TNBC) subtype specifically...
May 1, 2018: Oncotarget
Jacqueline F Yates, Matthew M Troester, David G Ingram
PURPOSE OF REVIEW: Congenital malformations of the central nervous system may be seen in isolation or in association with syndromes that have multiorgan involvement. Among the potential health challenges these children may face, sleep concerns are frequent and may include chronic insomnia, sleep-related breathing disorders, and circadian rhythm disorders. RECENT FINDINGS: In this review, we describe recent research into sleep disorders affecting children with congenital malformations of the CNS including visual impairment, septo-optic dysplasia, agenesis of the corpus callosum, Aicardi syndrome, Chiari malformation, spina bifida, achondroplasia, Joubert syndrome, fetal alcohol spectrum disorders, and congenital Zika syndrome...
May 23, 2018: Current Neurology and Neuroscience Reports
Y H Li, X S Shao, X H Jiang
No abstract text is available yet for this article.
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Hanneke Brits, Jeanie Adendorff, Dyanti Huisamen, Dahne Beukes, Kristian Botha, Hanre Herbst, Gina Joubert
BACKGROUND:  Neonatal jaundice affects one in two infants globally. The jaundice is the result of an accumulation of bilirubin as foetal haemoglobin is metabolised by the immature liver. High serum levels of bilirubin result in lethargy, poor feeding and kernicterus of the infant. AIM:  The main aim of this article was to determine the prevalence of neonatal jaundice and secondly to explore its risk factors in healthy term neonates. SETTING:  Maternity ward, National District Hospital, Bloemfontein, South Africa...
April 12, 2018: African Journal of Primary Health Care & Family Medicine
Loic Joubert-Doriol, Artur F Izmaylov
We review techniques for simulating fully quantum nonadiabatic dynamics using the frozen-width moving Gaussian basis functions to represent the nuclear wavefunction. A choice of these basis functions is primarily motivated by the idea of the on-the-fly dynamics that will involve electronic structure calculations done locally in the vicinity of each Gaussian center and thus avoiding "curse of dimensionality'' appearing in large systems. For quantum dynamics involving multiple electronic states there are several aspects that need to be addressed...
May 21, 2018: Journal of Physical Chemistry. A
M M Rahman, S M Rahman
Joubert's syndrome and related disorders are primarily disorder of cerebellar development. It has heterogeneity of presentation that varies from patient to patient. In the recent past we encountered a pair of children who presented with developmental delay, hypotonia and abnormal eye movements. Classic Joubert's syndrome was confirmed on the basis of clinical and neuro-imaging findings. So careful clinical assessment and appropriate neuro-imaging should be done in suspected cases for confirmation of diagnosis...
April 2018: Mymensingh Medical Journal: MMJ
Sidonie Lambert-Niclot, Maxime Grude, Jean-Luc Meynard, Anne-Geneviève Marcelin, Marc-Antoine Valantin, Philippe Flandre, Jacques Izopet, Laetitia Moinot, Vincent Bouteloup, Vincent Calvez, Christine Katlama, Pierre-Marie Girard, Laurence Morand-Joubert
Background: We pooled the results of three randomized trials that compared the efficacy of PI/r monotherapy and standard triple therapy as maintenance therapy and evaluated: 1) the distribution of ultrasensitive viral load (USVL) at week 96 (W96), 2) factors associated with virological success (VL<50 copy/mL) at W96, and 3) factors associated with USVL<1 copy/ml (c/ml) at W96. Methods: Virological failure was defined as two consecutive measurements of HIV-1 RNA viral load >50 copies/mL and was analyzed in intention-to-treat...
May 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Mokgadi Violet Gwangwa, Anna Margaretha Joubert, Michelle Helen Visagie
Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearly 100 years ago. Furthermore, increased reactive oxygen species (ROS) and lactate quantities increase metabolic, survival and proliferation signalling, resulting in increased tumourigenesis. In order to maintain redox balance, the cell possesses innate antioxidant defence systems such as superoxide dismutase, catalase and glutathione...
2018: Cellular & Molecular Biology Letters
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