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https://www.readbyqxmd.com/read/29055287/efficacy-and-tolerability-of-high-dose-pelargonium-extract-in-patients-with-the-common-cold
#1
David S Riley, Viktor G Lizogub, Andrea Zimmermann, Petra Funk, Walter Lehmacher
Context • The common cold (CC) is usually caused by a viral infection. Antibiotics are often prescribed unnecessarily for it, although no evidence exists for any benefit in the CC. Effective alternatives are needed. Objective • The study intended to evaluate the efficacy of 7630, a proprietary extract of Pelargonium sidoides, the active ingredient in umckaloabo, compared with a placebo for the treatment of the CC. Design • This was a prospective, double-blind, parallel-group, placebo-controlled, phase 3 clinical trial (RCT), with an adaptive group-sequential design with 2 parts, both of which were 2-arm trials...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055279/a-molecularly-imprinted-dual-emission-carbon-dot-quantum-dot-mesoporous-hybrid-for-ratiometric-determination-of-anti-inflammatory-drug-celecoxib
#2
Mohammad Amjadi, Roghayeh Jalili
We report on a ratiometric fluorescent sensor based on dual-emission molecularly imprinted mesoporous silica embedded with carbon dots and CdTe quantum dots (mMIP@CDs/QDs) for celecoxib (CLX) as target molecule. The fluorescence of the embedded CDs is insensitive to the analyte while the green emissive QDs are selectively quenched by it. This effect is much stronger for the MIP than for the non-imprinted polymer, which indicates a good recognition ability of the mesoporous MIP. The hybrid sensor also exhibited good selectivity to CLX over other substances...
October 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055277/structural-photophysical-and-theoretical-studies-of-imidazole-based-excited-state-intramolecular-proton-transfer-molecules
#3
Sivaraman Somasundaram, Eswaran Kamaraj, Su Jin Hwang, Sanghyuk Park
Imidazole-based excited state intramolecular proton transfer (ESIPT) blue fluorescent molecules, 2-(1-(4-chlorophenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol (BHPI-Cl) and 2-(1-(4-bromophenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol (BHPI-Br) were designed and synthesized by Debus-Radziszewski method through a one-pot multicomponent reaction in high yield. The synthesized compounds were fully characterized by (1)H NMR, (13)C NMR, FT-IR, FT-Raman, GC-Mass, and elemental analysis. The molecular structures in single crystal lattice were studied by X-ray crystallographic analysis...
October 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055258/cognitive-functioning-in-first-episode-bipolar-i-disorder-patients-with-and-without-history-of-psychosis
#4
Chakrabarty Trisha, Alamian Golnoush, Kozicky Jan-Marie, Ivan J Torres, Lakshmi N Yatham
BACKGROUND: Psychosis in bipolar I disorder (BDI) has been associated with increased cognitive dysfunction, which may relate to poorer functional outcomes. However, it is not known whether cognition differs between BDI patients with (BDP+) or without (BDP-) history of psychosis early in the disease course, or if it is impacted by the presence of mood congruent (MCP) versus incongruent (MIC) psychotic features. We compare cognition between these groups in BDI patients recently recovered from first episode of mania...
October 2, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29055198/dual-competitive-lateral-flow-aptasensor-for-detection-of-aflatoxin-b1-in-food-and-feedstuffs
#5
Chao Zhu, Guilan Zhang, Yafei Huang, Shuming Yang, Shuyue Ren, Zhixian Gao, Ailiang Chen
A novel dual-competitive lateral flow aptasensor (LFA) benefited from aptamer and lateral flow strips was first designed by using aflatoxin B1 (AFB1) as the model target. In this LFA assay, the target AFB1 competed with AFB1-hapten at T line for binding to Cy5-labeled AFB1 aptamer and the complementary strand competed with the target AFB1 for binding to Cy5-labeled AFB1 aptamer at C line. The ratio of their fluorescent intensities at the T line and C line (ST/SC ratio) was employed in order to increase the sensitivity for target AFB1 detection...
October 13, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29055194/a-graphene-quantum-dots-based-electrochemiluminescence-immunosensor-for-carcinoembryonic-antigen-detection-using-poly-5-formylindole-reduced-graphene-oxide-nanocomposite
#6
Guangming Nie, Yang Wang, Yun Tang, Dan Zhao, Qingfu Guo
A novel electrochemiluminescence (ECL) immunosensor for ultrasensitive detection of carcinoembryonic antigen (CEA) was developed using signal amplification strategy based on poly(5-formylindole)/reduced graphene oxide nanocomposite (P5FIn/erGO) and Au nanoparticle (AuNP) decorated graphene quantum dots (GQDs) (GQDs@AuNP). As an effective matrix for immobilization of primary antibody (Ab1), P5FIn/erGO nanocomposite facilitated the ion transport during the redox reactions and provided larger surface areas for the immobilization of Ab1...
October 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29055188/healthcare-investment-and-income-inequality
#7
Ayona Bhattacharjee, Jong Kook Shin, Chetan Subramanian, Shailender Swaminathan
This paper examines how the relative shares of public and private health expenditures impact income inequality. We study a two period overlapping generation's growth model in which longevity is determined by both private and public health expenditure and human capital is the engine of growth. Increased investment in health, reduces mortality, raises return to education and affects income inequality. In such a framework we show that the cross-section earnings inequality is non-decreasing in the private share of health expenditure...
October 7, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/29055059/application-of-the-bbcid-mass-spectrometry-approach-for-protein-glycosylation-and-phosphorylation-analysis
#8
Narciso Couto, Liliya Davlyatova, Caroline A Evans, Phillip C Wright
RATIONALE: Post-translational modified peptides analysis by mass spectrometry (MS) remains incomplete, in part due to incomplete sampling of all peptides which is inherent to traditional data-dependent acquisition (DDA). An alternative MS approach, data-independent acquisition (DIA), enables comprehensive recording of all detectable precursor and product ions, independent of precursor intensity. The use of broad band collision-induced dissociation (bbCID), a DIA method, was evaluated for the identification of protein glycosylation and phosphorylation...
October 21, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29054980/one-year-language-outcomes-in-toddlers-with-language-delays-an-rct-follow-up
#9
Lauren H Hampton, Ann P Kaiser, Megan Y Roberts
OBJECTIVES: The current study is a 1-year follow-up analysis of data from a randomized controlled trial of Enhanced Milieu Teaching (EMT) for toddlers with language delays. Outcomes and predictors of child language and parent intervention implementation were examined 6 and 12 months after the end of the intervention. METHODS: Toddlers with language delays were recruited from the community, and 97 toddlers and parents were randomly assigned to receive usual community treatments or a 3-month EMT intervention with parent training...
October 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/29054937/learning-from-errors-unnecessary-intensive-care-unit-admissions
#10
Cecil A Rambarat, David E Winchester
An elderly man was transferred to our emergency department with reported ventricular tachycardia requiring intravenous amiodarone and intensive care unit admission. Device interrogation, the following day, revealed only frequent premature ventricular contractions and non-sustained ventricular tachycardia in a patient with a known history of these conditions. The patient underwent unnecessary invasive monitoring after being emergently transferred to our facility and admitted to the intensive care unit. Fortunately, our patient did not suffer any unwarranted side effects from intravenous amiodarone...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054907/secondary-aortoduodenal-fistula-and-the-unrecognised-herald-bleed
#11
Francesc Simó Alari, Esther Molina González, Israel Gutierrez, Aïcha Ahamdanech-Idrissi
A 65-year-old man with history of aortobifemoral surgery 4 years ago was admitted to hospital after sudden abdominal pain. Initially misdiagnosed as renal colic, he was treated with analgesics, and while on observation he started with haematemesis, rapidly responding to volume infusion. Upper gastrointestinal endoscopy showed fresh blood in the stomach with no visible active bleeding. CT scan showed an important contrast extravasation from the aorta to the third duodenal portion, restarting haemodynamic instability and a cardiac arrest...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054892/transthoracic-littre-s-hernia-presenting-with-faecopneumothorax-following-perforation-of-the-meckel-s-diverticulum-a-late-complication-of-oesophagectomy
#12
Charles West, Karen Erskine, Khaled Hamdan
A Littre's hernia is an unusual phenomenon where a Meckel's diverticulum protrudes through a potential abdominal opening. We wish to present a unique case of a 79-year-old man with respiratory distress following a fall from standing, initially managed as a haemothorax. After a chest drain was placed, bowel contents were drained from the pleural cavity and he was taken to theatre. He had a history of minimally invasive oesophagectomy for cancer and had subsequently developed a diaphragmatic hernia. A blind ending diverticulum with a perforation at its tip was found in the left oblique lung fissure that was subsequently confirmed histologically as a perforated Meckel's diverticulum...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054886/the-ssu-processome-interactome-in-saccharomyces-cerevisiae-reveals-potential-new-protein-subcomplexes
#13
Nicholas G Vincent, J Michael Charette, Susan J Baserga
Ribosome assembly is an evolutionarily conserved and energy intensive process required for cellular growth, proliferation, and maintenance. In yeast, assembly of the small ribosomal subunit (SSU) requires approximately 75 assembly factors that act in coordination to form the SSU processome, a 6 MDa ribonucleoprotein complex. The SSU processome is required for processing, modifying, and folding the pre-ribosomal RNA (rRNA) to prepare it for incorporation into the mature SSU. Although the protein composition of the SSU processome has been known for some time, the interaction network of the proteins required for its assembly has remained poorly defined...
October 20, 2017: RNA
https://www.readbyqxmd.com/read/29054835/a-strategy-to-reduce-critical-cardiorespiratory-alarms-due-to-intermittent-enteral-feeding-of-preterm-neonates-in-intensive-care
#14
Rohan Joshi, Carola van Pul, Anouk Sanders, Hans Weda, Jan Willem Bikker, Loe Feijs, Peter Andriessen
BACKGROUND: Many preterm infants require enteral feeding as they cannot coordinate sucking, swallowing, and breathing. In enteral feeding, milk feeds are delivered through a small feeding tube passed via the nose or mouth into the stomach. Intermittent milk feeds may either be administered using a syringe to gently push milk into the infant's stomach (push feed) or milk can be poured into a syringe attached to the tube and allowed to drip in by gravity (gravity feed). This practice of enteral feeding is common in neonatal intensive care units...
October 20, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/29054757/mir-767-promoted-cell-proliferation-in-human-melanoma-by-suppressing-cyld-expression
#15
Kejin Zhang, Ling Guo
MicroRNAs (miRNAs) have emerged as critical regulators for cancer development and progression of human melanoma. However, the potential molecular mechanism of miR-767 in human melanoma has not been intensively investigated. In this present study, we confirmed that miR-767 was frequently up-regulated in human melanoma tissues and cell lines. Ectopic expression of miR-767 promoted cell proliferation in human melanoma cell lines A375 and WM35, whereas miR-767-in reversed the function. Bioinformatics analysis revealed that cylindromatosis (CYLD) was hypothesized to be a possible target gene of miR-767, and this was confirmed by luciferase activity assay...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29054740/cordycepin-inhibits-lps-induced-acute-lung-injury-by-inhibiting-inflammation-and-oxidative-stress
#16
Jiaji Lei, Youlei Wei, Pengcheng Song, Yongchao Li, Tianze Zhang, Qingjiang Feng, Guangquan Xu
Acute lung injury (ALI) is a common severe clinical syndrome in intensive care unit. Inflammation has been reported to play a critical role in the development of ALI. Cordycepin, an active component isolated from Cordyceps militaris, has been reported to have anti-inflammatory effects. However, the anti-inflammatory effects of cordycepin on LPS-induced ALI remain unclear. Therefore, in the present study, we assessed whether cordycepin could attenuate ALI induced by LPS. The mice were conditioned with cordycepin 1h before intranasal instillation of LPS...
October 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29054697/a-novel-method-for-oxygen-glucose-deprivation-model-in-organotypic-spinal-cord-slices
#17
Jing-Jie Liu, Xiao-Yan Ding, Li Xiang, Feng Zhao, Sheng-Li Huang
This study aimed to establish a model to closely mimic spinal cord hypoxic-ischemic injury with high production and high reproducibility. Fourteen-day cultured organotypic spinal cord slices were divided into 4 groups: control (Ctrl), oxygen glucose deprived for 30min (OGD 30min), OGD 60min, and OGD 120min. The Ctrl slices were incubated with 1ml propidium iodide (PI) solution (5μg/ml) for 30minutes. The OGD groups were incubated with 1ml glucose-free DMEM/F12 medium and 5μl PI solution (1mg/ml) for 30min, 60min and 120min, respectively...
October 17, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29054691/impact-of-critical-illness-polyneuromyopathy-in-rehabilitation-a-prospective-observational-study
#18
Cameron Cunningham, Heather C Finlayson, William R Henderson, Russell J O'Connor, Andrew Travlos
BACKGROUND: Critical illness polyneuromyopathy (CIPNM) is increasingly recognized as a source of disability in patients requiring intensive care unit (ICU) admission. The prevalence and impact of CIPNM on patients in the rehabilitation setting has not been established. OBJECTIVES: To determine the proportion of at-risk rehabilitation inpatients with evidence of CIPNM and the functional sequelae of this disorder. DESIGN: Prospective observational study...
October 17, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29054674/bacterial-communities-in-soil-become-sensitive-to-drought-under-intensive-grazing
#19
Stephanie D Jurburg, Tiago Natal-da-Luz, João Raimundo, Paula V Morais, José Paulo Sousa, Jan Dirk van Elsas, Joana Falcao Salles
Increasing climatic and anthropogenic pressures on soil ecosystems are expected to create a global patchwork of disturbance scenarios. Some regions will be strongly impacted by climate change, others by agricultural intensification, and others by both. Soil microbial communities are integral components of terrestrial ecosystems, but their responses to multiple perturbations are poorly understood. Here, we exposed soils from sustainably- or intensively-managed grasslands in an agro-silvo-pastoral oak woodland to month-long intensified drought and flood simulation treatments in a controlled mesocosm setting...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054643/polycyclic-aromatic-hydrocarbons-in-the-urban-atmosphere-of-nepal-distribution-sources-seasonal-trends-and-cancer-risk
#20
Balram Pokhrel, Ping Gong, Xiaoping Wang, Chuanfei Wang, Shaoping Gao
Atmospheric polycyclic aromatic hydrocarbons (PAHs) in urban areas have always been a global concern, as these areas are considered to be the source region. Despite studies on the concentrations of PAHs in water, soils and sediments, knowledge of the distribution patterns, seasonality and sources of PAHs in urban areas of Nepal remains limited. In this study, polyurethane foam passive air samplers were used to measure gas-phase PAH concentrations over different land types in three major cities of Nepal-namely, Kathmandu (the capital) and Pokhara (both densely populated cities), and Hetauda (an agricultural city)...
October 17, 2017: Science of the Total Environment
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