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https://www.readbyqxmd.com/read/29684892/effects-of-anxiety-and-mood-disorders-on-craving-and-substance-use-among-patients-with-substance-use-disorder-an-ecological-momentary-assessment-study
#1
Melina Fatseas, Fuschia Serre, Joel Swendsen, Marc Auriacombe
BACKGROUND: Despite recognition of the negative impact of psychiatric comorbidity on addictive disorders, the mechanisms underlying this association remain poorly understood. The present investigation applied mobile technologies to examine the effect of comorbid mood or anxiety disorders on craving intensity and substance use within the natural conditions of daily life. METHODS: A total of 159 participants were recruited from a French outpatient addiction clinic and completed two weeks of computerized ambulatory monitoring of daily life experiences using Ecological Momentary Assessment (EMA)...
April 12, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29684877/toxicity-and-mutagenicity-of-exhaust-from-compressed-natural-gas-could-this-be-a-clean-solution-for-megacities-with-mixed-traffic-conditions
#2
Avinash K Agarwal, Bushra Ateeq, Tarun Gupta, Akhilendra P Singh, Swaroop K Pandey, Nikhil Sharma, Rashmi A Agarwal, Neeraj K Gupta, Hemant Sharma, Ayush Jain, Pravesh C Shukla
Despite intensive research carried out on particulates, correlation between engine-out particulate emissions and adverse health effects is not well understood yet. Particulate emissions hold enormous significance for mega-cities like Delhi that have immense traffic diversity. Entire public transportation system involving taxis, three-wheelers, and buses has been switched from conventional liquid fuels to compressed natural gas (CNG) in the Mega-city of Delhi. In this study, the particulate characterization was carried out on variety of engines including three diesel engines complying with Euro-II, Euro-III and Euro-IV emission norms, one Euro-II gasoline engine and one Euro-IV CNG engine...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684832/effect-of-non-nutritive-sucking-and-sucrose-alone-and-in-combination-for-repeated-procedural-pain-in-preterm-infants-a-randomized-controlled-trial
#3
Haixia Gao, Mei Li, Honglian Gao, Guihua Xu, Fang Li, Jing Zhou, Yunsu Zou, Honghua Jiang
BACKGROUND: Sucrose combined with non-nutritive sucking provided better pain relief than sucrose or non-nutritive sucking alone in a single painful procedure. However, whether the combination of non-nutritive sucking with sucrose could obtain a significant difference in analgesic effect of the repeated procedural pain than any single intervention has not been established. OBJECTIVE: To compare the effect of non-nutritive sucking and sucrose alone and in combination of repeated procedural pain in preterm infants...
April 7, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29684812/quantitative-evaluation-of-the-matrix-effect-in-bioanalytical-methods-based-on-lc-ms-a-comparison-of-two-approaches
#4
Piotr J Rudzki, Elżbieta Gniazdowska, Katarzyna Buś-Kwaśnik
Liquid chromatography coupled to mass spectrometry (LC-MS) is a powerful tool for studying pharmacokinetics and toxicokinetics. Reliable bioanalysis requires the characterization of the matrix effect, i.e. influence of the endogenous or exogenous compounds on the analyte signal intensity. We have compared two methods for the quantitation of matrix effect. The CVs(%) of internal standard normalized matrix factors recommended by the European Medicines Agency were evaluated against internal standard normalized relative matrix effects derived from Matuszewski et al...
April 6, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684798/clinging-to-closeness-the-parental-view-on-developing-a-close-bond-with-their-infants-in-a-nicu
#5
Heli Mäkelä, Anna Axelin, Nancy Feeley, Hannakaisa Niela-Vilén
OBJECTIVE: To identify and understand how parents develop a close bond to their infants in the neonatal intensive care unit (NICU). DESIGN: A qualitative descriptive study; closeness and separation stories recorded in a smartphone application by the parents were analyzed using thematic analysis. SETTING AND PARTICIPANTS: Twenty-three parents of nineteen infants who were taken care of in a level III NICU in Finland. FINDINGS: Bonding moments and a disrupted dyadic parent-infant relationship continuously alternated as in a rollercoaster ride during the hospital stay...
April 11, 2018: Midwifery
https://www.readbyqxmd.com/read/29684783/accurate-segmenting-of-cervical-tumors-in-pet-imaging-based-on-similarity-between-adjacent-slices
#6
Liyuan Chen, Chenyang Shen, Zhiguo Zhou, Genevieve Maquilan, Kimberly Thomas, Michael R Folkert, Kevin Albuquerque, Jing Wang
Because in PET imaging cervical tumors are close to the bladder with high capacity for the secreted 18 FDG tracer, conventional intensity-based segmentation methods often misclassify the bladder as a tumor. Based on the observation that tumor position and area do not change dramatically from slice to slice, we propose a two-stage scheme that facilitates segmentation. In the first stage, we used a graph-cut based algorithm to obtain initial contouring of the tumor based on local similarity information between voxels; this was achieved through manual contouring of the cervical tumor on one slice...
April 16, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29684773/late-organ-failures-in-patients-with-prolonged-intensive-care-unit-stays
#7
Elizabeth M Viglianti, Rachel Kramer, Andrew J Admon, Michael W Sjoding, Carol L Hodgson, Rinaldo Bellomo, Theodore J Iwashyna
PURPOSE: The purpose of this study was to characterize the organ failures that develop among patients with prolonged ICU stays, defined as those who spent a minimum of 14 days in an ICU. METHODS: We retrospectively studied a cohort of consecutive patients from a university hospital who were in an ICU for a minimum of 14 days during 2014-2016. We calculated daily Sequential Organ Failure Assessment (SOFA) scores from admission to ICU day 14. The primary outcome was the number of new late organ failures, defined as occurring on ICU day 4 through 14...
April 4, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29684733/facile-preparation-of-high-density-polyethylene-superhydrophobic-superoleophilic-coatings-on-glass-copper-and-polyurethane-sponge-for-self-cleaning-corrosion-resistance-and-efficient-oil-water-separation
#8
Yuanyuan Cheng, Bei Wu, Xiaofan Ma, Shixiang Lu, Wenguo Xu, Sabine Szunerits, Rabah Boukherroub
Inspired by the lotus effect and water-repellent properties of water striders' legs, superhydrophobic surfaces have been intensively investigated from both fundamental and applied perspectives for daily and industrial applications. Various techniques are available for the fabrication of artificial superoleophilic/superhydrophobic (SS). However, most of these techniques are tedious and often require hazardous or expensive equipment, which hampers their implementation for practical applications. In the present work, we used a versatile and straightforward technique based on polymer drop-casting for the preparation SS materials that can be implemented on any substrate...
April 18, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29684686/a-comprehensive-profile-and-inter-individual-variations-analysis-of-the-human-normal-amniotic-fluid-proteome
#9
Xiang Liu, Yijun Song, Zhengguang Guo, Wei Sun, Juntao Liu
Amniotic fluid contains large amounts of proteins produced by amnion epithelial cells, fetal tissues, fetal excretions and placental tissues; thus, it is an important potential source of biomarkers for identifying fetal pathologies. In this study, a pooled AF sample from 7 healthy volunteers was used to provide a comprehensive profile of normal human AF proteome using immunoaffinity depletion of 14 high-abundance proteins. Each individual AF sample was used to analyze inter-individual variations with iTRAQ method...
April 20, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29684673/exercise-as-a-therapeutic-intervention-to-optimize-fetal-weight
#10
REVIEW
Laura M Reyes, Margie H Davenport
The Developmental Origins of Health and Disease suggest the in utero environment programs offspring obesity and cardiovascular disease. Therefore, there is a need to implement safe therapeutic interventions that do not involve the intake of medications or biological products during pregnancy that can improve maternal and fetal health. Prenatal exercise is established to promote maternal and fetal health. It is generally recommended that women accumulate at least 150 minutes per week of moderate-intensity exercise...
April 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29684627/bioadhesives-for-internal-medical-applications-a-review
#11
REVIEW
Wenzhen Zhu, Yon Jin Chuah, Dong-An Wang
Bioadhesives such as tissue adhesives, hemostatic agents, and tissue sealants have gained increasing popularity in different areas of clinical operations during the last three decades. Bioadhesives can be categorized into internal and external ones according to their application conditions. External bioadhesives are generally applied in topical medications such as wound closure and epidermal grafting. Internal bioadhesives are mainly used in intracorporal conditions with direct contact to internal environment including tissues, organs and body fluids, such as chronic organ leak repair and bleeding complication reduction...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684626/multi-scale-structural-design-and-biomechanics-of-the-pistol-shrimp-snapper-claw
#12
Shahrouz Amini, Maryam Tadayon, J Q Isaiah Chua, Ali Miserez
The Arthropoda, the largest phylum of the Animal Kingdom, have successfully evolved to survive various ecological constraints under a wide range of environmental conditions. Central to this survival are the structural designs developed in their exoskeletons and their raptorial appendages for protection and hunting. One such example, the pistol shrimp, is a shallow-water crustacean that is well-known for its aggressive hunting behavior, using its snapper claw to trigger the nucleation of cavitation bubbles that strike targets...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684583/a-novel-rpe65-inhibitor-cu239-suppresses-visual-cycle-and-prevents-retinal-degeneration
#13
Younghwa Shin, Gennadiy Moiseyev, Konstantin Petrukhin, Christopher L Cioffi, Parthasarathy Muthuraman, Yusuke Takahashi, Jian-Xing Ma
The retinoid visual cycle is an ocular retinoid metabolism specifically dedicated to support vertebrate vision. The visual cycle serves not only to generate light-sensitive visual chromophore 11-cis-retinal, but also to clear toxic byproducts of normal visual cycle (i.e. all-trans-retinal and its condensation products) from the retina, ensuring both the visual function and the retinal health. Unfortunately, various conditions including genetic predisposition, environment and aging may attribute to a functional decline of the all-trans-retinal clearance...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684565/thiotepa-based-intensified-reduced-intensity-conditioning-adult-double-unit-cord-blood-hematopoietic-stem-cell-transplantation-results-in-decreased-relapse-rate-and-improved-survival-compared-to-transplantation-following-standard-reduced-intensity-conditioning
#14
Prashant Sharma, Daniel A Pollyea, Clayton A Smith, Enkhtsetseg Purev, Manali Kamdar, Bradley Haverkos, Daniel Sherbenou, Rachel Rabinovitch, Andrew Hammes, Jonathan A Gutman
The "Minnesota" reduced intensity conditioning (RIC) cord-blood transplantation (CBT) regimen (standard-RIC) of fludarabine (Flu, 200mg/m2 ), cyclophosphamide (Cy, 50mg/kg), and 200cGy or 300cGy total body irradiation (TBI) is the most published RIC CBT regimen. Though well tolerated, high relapse rates remain a concern with this regimen. Intensification of conditioning may reduce relapse without increasing transplant related mortality (TRM). We performed a retrospective cohort comparison of outcomes in adult patients who underwent first double-unit CBT with standard-RIC as compared to the intensified regimen of fludarabine 150mg/m2 , cyclophosphamide 50mg/kg, thiotepa 10mg/kg and 400cGy TBI (intensified-RIC)...
April 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29684552/neonatal-whisker-trimming-in-wag-rij-rat-pups-causes-developmental-delay-encourages-maternal-care-and-affects-exploratory-activity-in-adulthood
#15
Kirill Smirnov, Daria Tsvetaeva, Evgenia Sitnikova
WAG/Rij rats are genetically predisposed to absence epilepsy. Maternal behavior in WAG/Rij female rats is known to differ from that in non-epileptic females. We hypothesize that (1) mother's behavior may be changed as response to changes in pup's conditions; (2) sensory deprivation at the neonatal age affect learning and behavior in adulthood. All whiskers in WAG/Rij rat pups were trimmed daily during PN1-PN8. Maternal behavior was examined during the same period. It was found that in the control group, WAG/Rij females often demonstrated abnormally long (>1 min) repetitive purposeless stereotypical actions that were roughly classified as compulsive-like behavior...
April 20, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29684533/lipid-coated-mannitol-core-microparticles-for-sustained-release-of-protein
#16
Bifeng Wang, Wolfgang Friess
Parenteral sustained release systems for proteins which provide therapeutic levels over a longer period avoiding frequent administration, which preserve protein stability during manufacturing, storage and application and which are biodegradable and highly biocompatible in the body are intensively sought after. The aim of this study was to generate and study mannitol core microparticles loaded with a monoclonal antibody IgG1 and coated with lipid either hard fat or glyceryl stearate at different coating levels...
April 20, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29684519/identification-of-a-transcription-factor-that-functions-downstream-of-corazonin-in-the-control-of-desert-locust-gregarious-body-color
#17
Ryohei Sugahara, Seiji Tanaka, Akiya Jouraku, Takahiro Shiotsuki
Corazonin (Crz) is a neuropeptide that controls phase-dependent body color polyphenism in locusts. The Crz signaling pathway is responsible for the development of gregarious black patterns in nymphs and determination of the morphometric ratio F/C (F = hind femur length, C = maximum head width) in adults. However, little information is available regarding the mediator and effector proteins regulated by Crz. In this study, we identified a novel transcriptional factor, Loct, which functions downstream of Crz in Schistocerca gregaria and Locusta migratoria...
April 20, 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29684391/a-randomized-control-trial-of-preoperative-prophylactic-antibiotics-prior-to-percutaneous-nephrolithotomy-in-low-infectious-risk-population-a-report-from-the-edge-consortium
#18
Ben H Chew, Nicole L Miller, Joel E Abbott, Dirk Lange, Mitchell R Humphreys, Vernon M Pais, Manoj Monga, Amy E Krambeck, Roger L Sur
INTRODUCTION: Single institution studies suggest a benefit of a week of preoperative antibiotics prior to percutaneous nephrolithotomy (PCNL). These studies are limited by lower quality methodology such as the inclusion of heterogeneous populations or the use of non-standard definitions of sepsis. The American Urological Association (AUA) Best Practice Statement recommends <24 hours of IV antibiotics, but no other data exist about the duration/benefit of preoperative antibiotics. We sought to perform a rigorous (using CONSORT guidelines), multi-institutional trial to assess preoperative antibiotics in PCNL patients at low risk of developing infections...
April 20, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29684374/single-center-experience-of-tracheobronchoplasty-for-tracheobronchomalacia-perioperative-outcomes
#19
Daniel H Buitrago, Adnan Majid, Daniel E Alape, Jennifer L Wilson, Mihir Parikh, Michael S Kent, Sidhu P Gangadharan
BACKGROUND: We aimed to present trends in practice as our experience has grown, and report the postoperative morbidity and its associated factors following tracheobronchoplasty. METHODS: Retrospective cohort study conducted in 161 patients who underwent tracheobronchoplasty from October 2002-September 2016. The main outcome was development of a postoperative complication within 30 days of surgery. Postoperative complication events were graded using the Clavien-Dindo system...
April 20, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29684341/predictors-of-outcome-in-patients-with-hematologic-malignancies-admitted-to-the-intensive-care-unit
#20
Nassar Al-Zubaidi, Emad Shehada, Khaled Alshabani, Jihane ZazaDitYafawi, Pascal Kingah, Ayman O Soubani
PURPOSE: Several studies showed conflicting results about prognosis and predictors of outcome of critically ill patients with hematological malignancies (HM). The aim of this study is to determine the hospital outcome of critically ill patients with HM and the factors predicting the outcome. METHODS AND MATERIALS: All patients with HM admitted to MICU at a tertiary academic medical center were enrolled. Clinical data upon admission and during ICU stay were collected...
April 17, 2018: Hematology/oncology and Stem Cell Therapy
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