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https://www.readbyqxmd.com/read/29224257/models-of-care-for-non-invasive-ventilation-in-the-acute-copd-comparison-of-three-tertiary-hospitals-act3-study
#1
Kerry Parker, Vara Perikala, Ali Aminazad, Zheng Deng, Brigitte Borg, Catherine Buchan, Jo Toghill, Louis B Irving, Jeremy Goldin, David Charlesworth, Ajay Mahal, Suhith Illesinghe, Matthew T Naughton, Alan Young
BACKGROUND AND OBJECTIVE: Non-invasive ventilation (NIV) improves clinical outcomes in hypercapnic acute exacerbations of COPD (AECOPD), but the optimal model of care remains unknown. METHODS: We conducted a prospective observational non-inferiority study comparing three models of NIV care: general ward (Ward) (1:4 nurse to patient ratio, thrice weekly consultant ward round), a high dependency unit (HDU) (1:2 ratio, twice daily ward round) and an intensive care unit (ICU) (1:1 ratio, twice daily ward round) model in three similar teaching tertiary hospitals...
December 10, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29224247/cortisol-and-blood-pressure-levels-decreased-in-fathers-during-the-first-hour-of-skin-to-skin-contact-with-their-premature-babies
#2
Natalia Varela, Réjean Tessier, George Tarabulsy, Tamarha Pierce
AIM: Premature birth is an extremely stressful experience. In 2013 to 2014 we explored the physiological stress responses of fathers during their first skin-to-skin contact with their new baby. METHODS: We recruited 49 fathers whose partners had given birth to a premature baby of up to 33 weeks and three days. The study, in the neonatal intensive care unit (NICU) of a Quebec hospital, measured the physiological stress responses of the fathers before and after they first experienced skin-to-skin contact with their new baby...
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29224200/mortality-in-acute-non-invasive-ventilation
#3
Dugal B Smith, George T P Tay, Karen Hay, Jijo Antony, Brendan Bell, Frances B Kinnear, Deanne L Curtin, James Douglas
A prospective study of non-invasive ventilation at The Prince Charles Hospital outside of the intensive care unit from March 2015 to March 2016 was performed. Overall 69 patients were included. Acute hypercapnic respiratory failure was the most common indication (n = 59; 85%). 49 (71%) had multifactorial respiratory failure. 15 (22%) patients died. Premorbid inability to perform self-care (P = 0.001) and the combination of mean pH < 7.25 and mean PaCO2 ≥ 75 mmHg within 2 h of NIV initiation (P = 0.037) were significantly associated with mortality...
December 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29224176/validation-of-a-method-for-estimating-energy-expenditure-during-walking-in-middle-aged-adults
#4
Nathan Caron, Teddy Caderby, Nicolas Peyrot, Chantal Verkindt, Georges Dalleau
PURPOSE: The aim of this study was to test the validity of a method using an inertial measurement unit for estimating activity-related energy expenditure (AEE) during walking in middle-aged adults. METHODS: Twenty healthy middle-aged participants completed different treadmill walking trials with an inertial measurement unit adhered to their lower back. Gas exchange was monitored with indirect calorimetry. Mechanical data were used to estimate AEE from an algorithm developed by Bouten et al...
December 9, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29224157/quantitative-dna-methylation-analysis-at-single-nucleotide-resolution-by-pyrosequencing%C3%A2
#5
Florence Busato, Emelyne Dejeux, Hafida El Abdalaoui, Ivo Glynne Gut, Jörg Tost
Many protocols for gene-specific DNA methylation analysis are either labor intensive, not quantitative and/or limited to the measurement of the methylation status of only one or very few CpG positions. Pyrosequencing is a real-time sequencing technology that overcomes these limitations. After bisulfite modification of genomic DNA, a region of interest is amplified by PCR with one of the two primers being biotinylated. The PCR generated template is rendered single-stranded and a pyrosequencing primer is annealed to analyze quantitatively cytosine methylation...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29224140/whole-genome-bisulfite-sequencing-using-the-ovation%C3%A2-ultralow-methyl-seq-protocol
#6
Christian Daviaud, Victor Renault, Florence Mauger, Jean-François Deleuze, Jörg Tost
The analysis of genome-wide epigenomic alterations including DNA methylation has become a subject of intensive research for many complex diseases. Whole-genome bisulfite sequencing (WGBS) using next-generation sequencing technologies can be considered the gold standard for a comprehensive and quantitative analysis of cytosine methylation throughout the genome. Several approaches including tagmentation- and post bisulfite adaptor tagging (PBAT)-based WGBS have been devised. Here, we provide a detailed protocol based on a commercial kit for the preparation of libraries for WGBS from limited amounts of input DNA (50-100 ng) using the classical approach of WGBS by ligation of methylated adaptors to the fragmented DNA prior to bisulfite conversion...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29224132/treatment-of-mild-to-moderate-hypoglycemia-in-patients-with-type-1-diabetes-treated-with-insulin-pump-therapy-are-current-recommendations-effective
#7
Véronique Gingras, Katherine Desjardins, Mohamed Raef Smaoui, Valérie Savard, Virginie Messier, Ahmad Haidar, Laurent Legault, Rémi Rabasa-Lhoret
AIMS: Mild-to-moderate hypoglycemia (blood glucose < 4.0 mmol/L) is recommended to be treated with 15 g of carbohydrates and to repeat the treatment if hypoglycemia persists after 15 min. This recommendation was established before intensive insulin therapy and based on studies using insulin with different pharmacokinetic profiles from actual insulin analogs showing that 15 g of glucose increases blood glucose by ~ 1.5 mmol/L in 15 min. We aimed to explore the effect of current recommended treatment of mild-to-moderate hypoglycemia in type 1 diabetes (T1D) participants and factors associated with treatment effectiveness...
December 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29224117/heated-communities-large-inter-and-intraspecific-variation-in-heat-tolerance-across-trophic-levels-of-a-soil-arthropod-community
#8
Oscar Franken, Milou Huizinga, Jacintha Ellers, Matty P Berg
Temperature extremes are predicted to increase in frequency, intensity and duration under global warming and are believed to significantly affect community composition and functioning. However, the effect of extreme climatic events on communities remains difficult to predict, especially because species can show dissimilar responses to abiotic changes, which may affect the outcome of species interactions. To anticipate community responses we need knowledge on within and among species variation in stress tolerance...
December 9, 2017: Oecologia
https://www.readbyqxmd.com/read/29224058/systematic-assessment-and-characterization-of-chronic-pain-in-multiple-sclerosis-patients
#9
Diana Ferraro, Domenico Plantone, Franca Morselli, Giulia Dallari, Anna M Simone, Francesca Vitetta, Patrizia Sola, Guido Primiano, Viviana Nociti, Matteo Pardini, Massimiliano Mirabella, Catello Vollono
Pain is one of the most disabling clinical symptoms in patients with multiple sclerosis (MS). Several studies have already assessed the prevalence of pain in MS patients, reporting variable results, probably due to methodological differences. The aim of this single-centre cross-sectional study was to define the prevalence and characteristics of chronic pain in a population of MS patients using validated tools, and to analyse these data in relation to demographic and clinical features, including disease duration and disability (EDSS and its single functional system scores)...
December 9, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29224039/state-of-the-art-lasers-and-light-treatments-for-vascular-lesions-from-red-faces-to-vascular-malformations
#10
Manuel Valdebran, Brent Martin, Kristen M Kelly
Notable milestones in the treatment of vascular lesions have been achieved over the past century. Many cutaneous vascular lesions can be successfully treated with lightbased devices. In this review, we will discuss the treatment of port-wine birthmarks, lymphatic malformations, infantile hemangiomas, rosacea, venous lakes, pyogenic granulomas, cherry angiomas, and angiofibromas using lasers, total reflection amplification of spontaneous emission of radiation, intense pulsed light, and photodynamic therapy. In addition, for several of these diagnoses, we will review medical therapies that can be combined with light-based devices to provide enhanced results...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29223999/two-years-follow-up-of-patients-with-abnormal-uterine-bleeding-after-insertion-of-the-levonorgestrel-releasing-intrauterine-system
#11
Numan Cim, Sunullah Soysal, Sena Sayan, Begum Yildizhan, Erbil Karaman, Orkun Cetin, Harun Egemen Tolunay, Recep Yildizhan
AIM: To evaluate the efficacy and safety of levonorgestrel-releasing intrauterine system (LNG-IUS) in the long-term treatment of heavy menstrual blood loss in women unrelated to intrauterine pathology. METHODS: One hundred and six parous women aged 33-48 years with recurrent heavy menstrual bleeding (HMB) participated in this study. The women were followed up for 24 months and were assessed for intensity of bleeding both for pre- and post-insertion periods. An LNG-IUS was inserted in each patient within 7 days of the start of menstrual flow...
December 8, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29223991/a-patient-risk-model-of-chemotherapy-induced-febrile-neutropenia-lessons-learned-from-the-anc-study-group
#12
REVIEW
Gary H Lyman, Marek S Poniewierski
Neutropenia and its complications, including febrile neutropenia (FN), represent major toxicities associated with cancer chemotherapy, resulting in considerable morbidity, mortality, and costs. The myeloid growth factors such as granulocyte colony-stimulating factor (G-CSF) have been shown to reduce the risk of neutropenia complications while enabling safe and effective chemotherapy dose intensity. Concerns about the high costs of these agents along with limited physician adherence to clinical practice guidelines, resulting in both overuse and underuse, has stimulated interest in models for individual patient risk assessment to guide appropriate use of G-CSF...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29223988/prevalence-of-physical-problems-detected-by-the-distress-thermometer-and-problem-list-in-patients-with-myeloproliferative-disorders
#13
Daniel C McFarland, Kelly M Shaffer, Heather Polizzi, John Mascarenhas, Marina Kremyanskaya, Jimmie Holland, Ronald Hoffman
Background: Patients with myeloproliferative neoplasms (MPNs) can have a severe physical symptom burden over an extended disease trajectory that contributes to decreased quality of life. Few studies, however, have characterized which patients most frequently consider physical symptoms a problem. This study describes the physical symptoms of patients with MPNs and the relationship of these symptoms to patient characteristics. Methods: Patients with MPNs (N=117) completed questionnaires in a dedicated academic medical center MPN clinic...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29223941/-medical-futility-and-family-obstinacy-in-intensive-therapy-when-to-stop-and-when-to-keep-going
#14
Alejandro R Grinberg, Vilma A Tripodoro
There have been several recent publications related to therapeutic obstinacy and futility in the Intensive Care Unit. However, little has been published about "the family obstinacy" in persisting with invasive measures in seriously ill patients, despite the appropriate information provided to them about the patient's poor short-term prognosis. On certain occasions, these critical patients are unable to make decisions on the proposed treatments and, unfortunately, many of them have not previously indicated their preferences in terms of limits to invasive measures (advanced directives)...
2017: Medicina
https://www.readbyqxmd.com/read/29223911/pcbs-and-pcdd-fs-in-soil-from-informal-e-waste-recycling-sites-and-open-dumpsites-in-india-levels-congener-profiles-and-health-risk-assessment
#15
Paromita Chakraborty, Sakthivel Selvaraj, Masafumi Nakamura, Balasubramanian Prithiviraj, Alessandra Cincinelli, John J Bang
Growth of informal electronic waste (e-waste) recycling sector is an emerging problem for India. The presence of halogenated compounds in e-wastes may result in the formation of persistent organic pollutants like polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) during recycling processes. We therefore investigated PCBs and PCDD/Fs in surface soils explicitly from the informal e-waste recycling sites and nearby open dumpsites of major metropolitan cities from four corners of India, viz...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223907/analytical-indicators-to-characterize-particulate-organic-matter-pom-and-its-evolution-in-french-vertical-flow-constructed-wetlands-vfcws
#16
M Kania, M Gautier, Z Ni, E Bonjour, R Guégan, P Michel, P Jame, J Liu, R Gourdon
The design of French VFCWs leads to the formation of a sludge layer at the surface of the first filters due to the retention of suspended solids from the percolation of unsettled wastewater. This layer plays a major role in the system but still little is known on its characteristics and evolutions. In this study, suspended solids and sludge deposits sampled from two French VFCW plants were analyzed by different methods in the objective to assess the evolution of particulate organic matter (POM) along the treatment chain and within the sludge layer, and identify relevant analytical indicators of these phenomena...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223900/driving-factors-of-soil-carbon-accumulation-in-oxisols-in-long-term-no-till-systems-of-south-brazil
#17
Ademir de Oliveira Ferreira, Telmo Jorge Carneiro Amado, Charles W Rice, Dorivar A Ruiz Diaz, Clever Briedis, Thiago Massao Inagaki, Daniel Ruiz Potma Gonçalves
In a climate change scenario, it is important to understand the factors that lead to changes in a soil carbon (C) sink. It is recognized that such process is highly dependent on climate, soil properties, topography, and vegetation. However, few studies demonstrate how these mechanisms operate in highly weathered Oxisols. Therefore, this study evaluated the driving factors for C recovery and accumulation and its relations with fertility attributes in the soil profile (0 to 1m depth) in no-till (NT) croplands of south Brazil...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223896/environmental-status-of-livestock-and-poultry-sectors-in-china-under-current-transformation-stage
#18
Yi Qian, Kaihui Song, Tao Hu, Tianyu Ying
Intensive animal husbandry had aroused great environmental concerns in many developed countries. However, some developing countries are still undergoing the environmental pollution from livestock and poultry sectors. Driven by the large demand, China has experienced a remarkable increase in dairy and meat production, especially in the transformation stage from conventional household breeding to large-scale industrial breeding. At the same time, a large amount of manure from the livestock and poultry sector is released into waterbodies and soil, causing eutrophication and soil degradation...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223871/intensity-ratio-to-improve-black-hole-assessment-in-multiple-sclerosis
#19
Gautam Adusumilli, Kathryn Trinkaus, Peng Sun, Samantha Lancia, Jeffrey D Viox, Jie Wen, Robert T Naismith, Anne H Cross
BACKGROUND: Improved imaging methods are critical to assess neurodegeneration and remyelination in multiple sclerosis. Chronic hypointensities observed on T1-weighted brain MRI, "persistent black holes," reflect severe focal tissue damage. Present measures consist of determining persistent black holes numbers and volumes, but do not quantitate severity of individual lesions. OBJECTIVE: Develop a method to differentiate black and gray holes and estimate the severity of individual multiple sclerosis lesions using standard magnetic resonance imaging...
December 2, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29223846/clinical-features-and-surgical-outcomes-of-pulmonary-artery-sarcoma
#20
Kanhua Yin, Zhiqi Zhang, Rongkui Luo, Yuan Ji, Difan Zheng, Yi Lin, Chunsheng Wang
OBJECTIVE: Pulmonary artery sarcoma is an exceedingly rare malignancy. There is a lack of consensus regarding its diagnosis and treatment. We reviewed our experience in the surgical management of pulmonary artery sarcoma over an 11-year period. METHODS: From January 2005 to February 2016, 12 patients with pulmonary artery sarcoma (age 51 ± 14 years, 5 male) underwent surgical treatment at our center. Nine patients (75%) exhibited pulmonary trunk involvement on computed tomography angiography...
November 10, 2017: Journal of Thoracic and Cardiovascular Surgery
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