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https://www.readbyqxmd.com/read/29338844/sfe-sfedp-adrenal-insufficiency-french-consensus-introduction-and-handbook
#1
Yves Reznik, Pascal Barat, Jérôme Bertherat, Claire Bouvattier, Frédéric Castinetti, Olivier Chabre, Philippe Chanson, Christine Cortet, Brigitte Delemer, Bernard Goichot, Damien Gruson, Laurence Guignat, Emmanuelle Proust-Lemoine, Marie-Laure Raffin Sanson, Rachel Reynaud, Dinane Samara Boustani, Dominique Simon, Antoine Tabarin, Delphine Zenaty
The French endocrinology society (SFE) and the French pediatric endocrinology society (DFSDP) have drawn up recommendations for the management of primary and secondary adrenal insufficiency in the adult and child, based on an analysis of the literature by 19 experts in 6 work-groups. A diagnosis of adrenal insufficiency should be suspected in the presence of a number of non-specific symptoms except hyperpigmentation which is observed in primary adrenal insufficiency. Diagnosis rely on plasma cortisol and ACTH measurement at 8am and/or the cortisol increase after synacthen administration...
January 12, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29334626/parenting-predicts-strange-situation-cortisol-reactivity-among-children-adopted-internationally
#2
Carrie E DePasquale, K Lee Raby, Julie Hoye, Mary Dozier
The functioning of the hypothalamic pituitary adrenal (HPA) axis can be altered by adverse early experiences. Recent studies indicate that children who were adopted internationally after experiencing early institutional rearing and unstable caregiving exhibit blunted HPA reactivity to stressful situations. The present study examined whether caregiving experiences post-adoption further modulate children's HPA responses to stress. Parental sensitivity during naturalistic parent-child play interactions was assessed for 66 children (M age = 17...
January 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29329340/cognitive-control-moderates-parenting-stress-effects-on-children-s-diurnal-cortisol
#3
Laurel Raffington, Florian Schmiedek, Christine Heim, Yee Lee Shing
This study investigated associations between parenting stress in parents and self-reported stress in children with children's diurnal cortisol secretion and whether these associations are moderated by known stress-regulating capacities, namely child cognitive control. Salivary cortisol concentrations were assessed from awakening to evening on two weekend days from 53 6-to-7-year-old children. Children completed a cognitive control task and a self-report stress questionnaire with an experimenter, while parents completed a parenting stress inventory...
2018: PloS One
https://www.readbyqxmd.com/read/29324397/serum-levels-of-cortisol-dehydroepiandrosterone-and-oxytocin-in-children-with-attention-deficit-hyperactivity-disorder-combined-presentation-with-and-without-comorbid-conduct-disorder
#4
Ümit Işık, Ayhan Bilgiç, Aysun Toker, Ibrahim Kılınç
The present study aimed to investigate serum cortisol, dehydroepiandrosterone (DHEA), and oxytocin levels of children with attention-deficit/hyperactivity disorder (ADHD) combined presentation and those diagnosed with ADHD combined presentation and coexisting conduct disorder. A total of 74 drug-naive children with ADHD combined presentation alone, 32 children with ADHD combined presentation + conduct disorder, and 42 healthy controls were included. The severities of ADHD and conduct disorder symptoms were assessed via parent- and teacher-rated questionnaires...
January 2, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29305885/a-state-trait-model-of-cortisol-in-early-childhood-contextual-and-parental-predictors-of-stable-and-time-varying-effects
#5
Stephanie F Thompson, Maureen Zalewski, Cara J Kiff, Liliana J Lengua
This study examined state-trait models of diurnal cortisol (morning level and diurnal slope), and whether income, cumulative risk and parenting behaviors predicted variance in trait and state levels of cortisol. The sample of 306 mothers and their preschool children included 29% families at or near poverty, 27% families below the median income, and the remaining families at middle and upper income. Diurnal cortisol, income, cumulative risk, and parenting were measured at 4 time points, once every 9months, starting when children were 36-40months...
January 3, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29286515/cortisol-level-as-risk-factor-for-malignant-hematologic-pathology-in-children-exposed-to-ionizing-radiation-after-chornobyl-accident
#6
V G Bebeshko, K M Bruslova, T I Pushkareva, N M Tsvietkova, L O Lyashenko, A S Sergeeva, V F Kuzmenko, S M Iatsemyrskiy, Yu M Samson, V G Boyarsky, I V Tryhlіb
OBJECTIVE: Determination of serum cortisol level in the initial period of acute leukemia in children, who exposed to ion izing radiation and other factors of Chornobyl accident, depending on their age and prognosis of disease. MATERIALS AND METHODS: The study involved 283 children residents of Kyiv, Zhytomyr and Chernihiv regions. There were 90 acute leukemia patients(AL) (ALL - 56, AML - 34), and 193 people of comparison group with anemia, leukemoid reactions and lymphadenopathy...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29280740/latest-insights-on-the-etiology-and-management-of-primary-adrenal-insufficiency-in-children
#7
Tülay Güran
Primary adrenal insufficiency (PAI) is a heterogeneous group of clinical and genetic disorders characterized by an impaired production of cortisol and other steroid hormones by the adrenal cortex. Most of the causes of PAI in childhood are inherited and monogenic in origin and are associated with significant morbidity and mortality whenever the diagnosis and treatment is delayed. Therefore, early and accurate diagnosis would allow appropriate management for the patients and more accurate genetic counseling for the family...
December 27, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29278385/a-survey-of-naturally-occurring-steroid-hormones-in-raw-milk-and-the-associated-health-risks-in-tangshan-city-hebei-province-china
#8
Xueyin Qu, Chuanyou Su, Nan Zheng, Songli Li, Lu Meng, Jiaqi Wang
In recent years, high levels of hormone residue in food, capable of damaging the health of consumers, have been recorded frequently. In this study, 195 raw milk samples were obtained from Tangshan City, China, and the concentrations of 22 steroid hormones were measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Cortisol was detected in 12.5% of raw milk samples (mean 0.61 µg/kg; range: <limit of quantification (LOQ)-0.94 µg/kg). Progesterone was detected in 85.9% of raw milk samples (mean 5...
December 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29277706/androgen-excess-is-due-to-elevated-11-oxygenated-androgens-in-treated-children-with-congenital-adrenal-hyperplasia
#9
Clemens Kamrath, Lisa Wettstaedt, Claudia Boettcher, Michaela F Hartmann, Stefan A Wudy
Adrenal androgen excess is the hallmark of classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Recently, 11-oxygenated C19 steroids, a class of highly active adrenal-derived androgens, have been described in patients with CAH. The aim of our study was to elucidate the significance of 11-oxygenated androgens in children with CAH. We retrospectively analysed 190 daily urinary excretion rates of glucocorticoid-, 17α-hydroxyprogesterone (17OHP)-, and androgen metabolites determined by gas chromatography-mass spectrometry of 99 children aged 3...
December 23, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29262485/-association-between-hair-cortisol-concentration-and-overweight-and-obesity-in-6-9-years-old-childhood
#10
J J Hu, X N Duan, J Fang, N Xu, Y H Wan, P Y Su, F B Tao, Y Sun
Objective: To determine the possible relations between hair cortisol concentration (HCC) as a biomarker of chronic stress and childhood overweight and obesity. Methods: Children from grade 1 to 3 from 2 primary schools in Bengbu were invited to participate in the study; and those who suffer from mental disorders, endocrine diseases and those who took hormone drugs were excluded. Parental questionnaire was implemented to collect information on physical activity, screen time, sleep duration, sugar-beverage consumption, as well as socio-economic status...
December 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29248565/person-centered-examination-of-salivary-cortisol-and-alpha-amylase-responses-to-psychosocial-stress-links-to-preadolescent-behavioral-functioning-and-coping
#11
Jason José Bendezú, Martha E Wadsworth
This study adopted a person-centered approach to identify preadolescent salivary cortisol (sC) and alpha-amylase (sAA) co-activation response patterns and examine links to behavioral functioning and coping. Children (N = 151, 51.7% male) were exposed to the Trier Social Stress Test (TSST) and one of two randomly-assigned, post-TSST coping conditions: distraction or avoidance. Multi-trajectory modeling yielded four child subgroups. Child internalizing and externalizing positively predicted High sC-High sAA relative to Low sC-Low sAA and Low sC-High sAA relative to High sC-Low sAA subgroup membership, respectively...
December 14, 2017: Biological Psychology
https://www.readbyqxmd.com/read/29242410/adiposity-and-cortisol-response-to-stress-in-indian-adolescents
#12
G V Krishnaveni, A Jones, S R Veena, R Somashekara, S C Karat, C H D Fall
OBJECTIVE: Greater adiposity is a risk factor for altered hypothalamic-pituitary-adrenal axis reactivity to stress. We examined associations of different adiposity measures with cortisol responses during the Trier Social Stress Test for children (TSST-C). DESIGN: Cohort study. SETTING: Holdsworth Memorial Hospital, Mysore, India. PARTICIPANTS: Adolescents aged 13.5y from a birth cohort were recruited (N=269, 133 boys)...
December 14, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29237154/effects-of-early-life-adversity-on-hippocampal-structures-and-associated-hpa-axis-functions
#13
Brigitte Dahmen, Vanessa B Puetz, Wolfgang Scharke, Georg G von Polier, Beate Herpertz-Dahlmann, Kerstin Konrad
Early-life adversity (ELA) is one of the major risk factors for serious mental and physical health risks later in life. ELA has been associated with dysfunctional neurodevelopment, especially in brain structures such as the hippocampus, and with dysfunction of the stress system, including the hypothalamic-pituitary-adrenal (HPA) axis. Children who have experienced ELA are also more likely to suffer from mental health disorders such as depression later in life. The exact interplay of aberrant neurodevelopment and HPA axis dysfunction as risks for psychopathology is not yet clear...
December 14, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/29226590/dheas-patterning-across-childhood-in-three-sub-saharan-populations-associations-with-age-sex-ethnicity-and-cortisol
#14
Courtney Helfrecht, Edward H Hagen, David DeAvila, Robin M Bernstein, Samuel J Dira, Courtney L Meehan
OBJECTIVES: Hormones have many roles in human ontogeny, including the timing of life history 'switch points' across development. Limited hormonal data exist from non-Western children, leaving a significant gap in our understanding of the diversity of life history patterning. This cross-sectional study examines dehydroepiandrosterone sulfate (DHEAS) production in relation to age, sex, ethnicity, and cortisol concentrations, as well as average age of adrenarche, among Aka and Ngandu children of the Central African Republic and Sidama children of Ethiopia...
December 11, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29225338/early-life-adversity-and-cortisol-response-to-social-stress-a-meta-analysis
#15
Ioana Maria Bunea, Aurora Szentágotai-Tătar, Andrei C Miu
Early-life adversity has been associated with a life-long increased risk for psychopathology and chronic health problems. These long-term negative effects have been explained through stress sensitization, which may involve dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis through either increased or decreased reactivity. The present meta-analysis assessed for the first time the effect of early-life adversity on cortisol response to social stress. Thirty data sets were included in the meta-analysis, in which early-life adversity and salivary cortisol response to social stress were assessed in 4292 individuals of different ages...
December 11, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29211058/decreased-lymphocytes-and-increased-risk-for-infection-are-common-in-endogenous-pediatric-cushing-syndrome
#16
Christina Tatsi, Rebecca Boden, Ninet Sinaii, Meg Keil, Charalampos Lyssikatos, Elena Belyavskaya, Sergio D Rosenzweig, Constantine A Stratakis, Maya B Lodish
BackgroundHypercortisolemia results in changes of the immune system and elevated infection risk, but data on the WBC changes in pediatric Cushing syndrome (CS) are not known. We describe the changes of the WBC lineages in pediatric endogenous hypercortisolemia, their associations with the markers of disease severity, and the presence of infections.MethodsWe identified 197 children with endogenous CS. Clinical and biochemical data were recorded. Sixty-six children with similar age and gender, and normocortisolemia served as controls...
December 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29209670/inflammatory-parameters-in-sexually-abused-children
#17
Serbülent Kılıç, Kara Ozlem, Tutanc Murat
To investigate whether serum levels of cortisol, interleukin-6 and interleukin-10 differed between children with or without a sexual trauma. Methods: This descriptive study was conducted in the Department of Child Protective Service (CPS), Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey, between May 2016 and July 2016. Three different markers (cortisol, interleukin-6 and interleukin-10) were used to perform this experiment. We included 17 children age less than 18 years old and sexually abused, and 10 children who were not abused as a control group...
December 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/29196916/bullying-victimization-heightens-cortisol-response-to-psychosocial-stress-in-chinese-children
#18
Guanghui Chen, Yanhong Kong, Kirby Deater-Deckard, Wenxin Zhang
Childhood adverse experiences have been consistently documented to engender persistent changes in the hypothalamic-pituitary-adrenal (HPA) axis reactivity to chronic stress. However, there has been very little research examining whether this effect can be elicited among children when using a standardized laboratory stress test, or whether such effects are found in non-Western youth. In the current study, 80 10-year-old Chinese children (45% girls, 4-5th grades) were selected from 970 students based on the experience of being bullied, resulting in a sample of 59 victims (physical, verbal, and relational/social), and a group of 21 nonbullied children with distributions of age and gender that were comparable...
December 2, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29175821/post-traumatic-stress-after-picu-and-corticosteroid-use
#19
Georgina Corbet Burcher, Maria D Picouto, Lorraine C Als, Mehrengise Cooper, Christine M Pierce, Simon Nadel, M Elena Garralda
AIM: To examine the association between corticosteroid use in paediatric intensive care units (PICU) and subsequent symptoms of post-traumatic stress disorder (PTSD). METHODS: The subjects were children aged 8-16 years admitted to PICU with sepsis, meningoencephalitis (ME) and other disorders. Illness information was extracted from case notes; 3-6 months post discharge children completed a PTSD symptom questionnaire (eight-item Impact of Events Scale (IES-8)) assessing intrusion and avoidance symptoms...
November 25, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29174200/group-2-adrenal-insufficiency-screening-methods-and-confirmation-of-diagnosis
#20
Philippe Chanson, Laurence Guignat, Bernard Goichot, Olivier Chabre, Dinane Samara Boustani, Rachel Reynaud, Dominique Simon, Antoine Tabarin, Damien Gruson, Yves Reznik, Marie-Laure Raffin Sanson
A diagnosis of adrenal insufficiency should be suspected in the presence of a number of non-specific symptoms (fatigue, anorexia, weight loss, hypotension, hyponatremia and hyperkalemia amongst adrenal causes of insufficiency). The diagnosis should be considered in case of pituitary disease or a state of shock. Treatment should be commenced immediately without waiting for confirmation from biochemical tests, which rely on cortisol level at 8am (expected to be low) and on ACTH level (expected to be high in the case of primary adrenal insufficiency)...
December 2017: Annales D'endocrinologie
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