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https://www.readbyqxmd.com/read/27909452/the-levels-of-cortisol-and-oxidative-stress-and-dna-damage-in-child-and-adolescent-victims-of-sexual-abuse-with-or-without-post-traumatic-stress-disorder
#1
Şeref Şimşek, Tuğba Yüksel, İbrahim Kaplan, Cem Uysal, Hüseyin Aktaş
OBJECTIVE: The aim of this study was to investigate whether cortisol and oxidative stress levels and DNA damage differ between individuals who developed PTSD or not following a sexual trauma. METHODS: The study included 61 children aged between 5 and 17 years who sustained sexual abuse (M/F: 18/43). The patients were divided into two groups: patients with PTSD and patients without PTSD based, based on the results of a structured psychiatric interview (K-SADS-PL and CAPS-CA)...
November 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27908974/effects-of-a-humor-therapy-program-on-stress-levels-in-pediatric-inpatients
#2
Julio C Sánchez, Luis F Echeverri, Manuel J Londoño, Sergio A Ochoa, Andrés F Quiroz, César R Romero, Joaquín O Ruiz
OBJECTIVE: Disease and hospitalization generate stress, which can affect the response to treatment. Humor has been used in many hospitals to decrease stress. The aim of this study was to evaluate the impact of a humor therapy program on stress levels in pediatric inpatients. METHODS: In the first phase, an intervention and a control group were studied over 2 consecutive 3-month periods; the interventions were performed by a team of artists trained in humor therapy...
December 1, 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27893234/mindful-parenting-predicts-mothers-and-infants-hypothalamic-pituitary-adrenal-activity-during-a-dyadic-stressor
#3
Heidemarie K Laurent, Larissa G Duncan, April Lightcap, Faaiza Khan
Mindfulness in the parenting relationship has been proposed to help both parents and children better regulate stress, though this has not yet been shown at the physiological level. In this study, we tested relations between maternal mindfulness in parenting and both mothers' and their infants' hypothalamic-pituitary-adrenal (HPA) axis activity during a dyadic stressor 3 months later. Participants were 73 mother-infant dyads from a larger longitudinal study. At 3 months postpartum, mothers completed self-report measures of general dispositional mindfulness and parenting-specific mindfulness, as well as stressful life events...
November 28, 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27879325/cushing-syndrome-in-a-child-due-to-pro-opiomelanocortin-pomc-secretion-from-a-yolk-sac-tumor
#4
Evelien Gevers, Suzanne Meredith, Pratik Shah, John Torpiano, Catherine Peters, Neil Sebire, Olga Slater, Anne White, Mehul Datani
CONTEXT: Pituitary microadenomas and adrenal tumours are the most common causes for endogenous Cushing syndrome (CS) in children. CASE DESCRIPTION: We describe a two-year old girl with Cushing syndrome due to ectopic pro-opiomelanocortin (POMC) production from an abdominal yolk sac tumor. Cortisol concentrations were elevated but adrenocorticotropic hormone (ACTH) concentrations were equivocal. The use of antibodies specifically detecting ACTH precursors revealed that plasma ACTH precursors were elevated...
November 22, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27865992/in-6-to-8-year-old-children-hair-cortisol-is-associated-with-body-mass-index-and-somatic-complaints-but-not-with-stress-health-related-quality-of-life-blood-pressure-retinal-vessel-diameters-and-cardiorespiratory-fitness
#5
Markus Gerber, Katharina Endes, Serge Brand, Christian Herrmann, Flora Colledge, Lars Donath, Oliver Faude, Uwe Pühse, Henner Hanssen, Lukas Zahner
OBJECTIVES: Hair cortisol measurement has become an increasingly accepted approach in endocrinology and biopsychology. However, while in adult research hair cortisol has been proposed as a relevant biomarker for chronic stress (and its adverse consequences), studies with children are scarce. Therefore, the goal of the present exploratory study was to examine the associations between hair cortisol concentrations (HCCs), stress, and a series of health-related outcomes in a sample of Swiss first grade schoolchildren...
November 9, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27849625/cortisol-response-to-adrenocorticotropin-testing-in-non-classical-congenital-adrenal-hyperplasia-nccah
#6
Fotini-Heleni Karachaliou, Maria Kafetzi, Maria Dracopoulou, Elpis Vlachopapadopoulou, Sofia Leka, Aspasia Fotinou, Stefanos Michalacos
BACKGROUND: The adequacy of cortisol response in non-classical congenital adrenal hyperplasia (NCCAH) has not been fully elucidated. The aim was to evaluate cortisol response to adrenocorticotropin (ACTH) stimulation test in children and adolescents with NCCAH and heterozygotes for CYP21A2 gene mutations. METHODS: One hundred and forty-six children and adolescents, mean age 7.9 (0.7-17.5) years with clinical hyperandrogenism, were evaluated retrospectively. Thirty-one subjects had NCCAH, 30 were heterozygotes for CYP21A2 gene mutations, while 85 showed normal response to ACTH test...
December 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27822302/do-post-trauma-symptoms-mediate-the-relation-between-neurobiological-stress-parameters-and-conduct-problems-in-girls
#7
Kimberly A Babel, Tijs Jambroes, Sanne Oostermeijer, Peter M van de Ven, Arne Popma, Robert R J M Vermeiren, Theo A H Doreleijers, Lucres M C Jansen
OBJECTIVE: Attenuated activity of stress-regulating systems has consistently been reported in boys with conduct problems. Results in studies of girls are inconsistent, which may result from the high prevalence of comorbid post-trauma symptoms. Therefore, the aim of the present study is to investigate post-trauma symptoms as a potential mediator in the relation between stress-regulation systems functioning and conduct problems in female adolescents. METHODS: The sample consisted of 78 female adolescents (mean age 15...
2016: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/27821114/bright-light-therapy-in-pregnant-women-with-major-depressive-disorder-study-protocol-for-a-randomized-double-blind-controlled-clinical-trial
#8
Babette Bais, Astrid M Kamperman, Marjolein D van der Zwaag, Gwen C Dieleman, Hanneke W Harmsen van der Vliet-Torij, Hilmar H Bijma, Ritsaert Lieverse, Witte J G Hoogendijk, Mijke P Lambregtse-van den Berg
BACKGROUND: Depression during pregnancy is a common and high impact disease. Generally, 5-10 % of pregnant women suffer from depression. Children who have been exposed to maternal depression during pregnancy have a higher risk of adverse birth outcomes and more often show cognitive, emotional and behavioural problems. Therefore, early detection and treatment of antepartum depression is necessary. Both psychotherapy and antidepressant medication, first choice treatments in a non-pregnant population, have limitations in treating depression during pregnancy...
November 8, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27810705/the-impact-of-daily-and-trait-loneliness-on-diurnal-cortisol-and-sleep-among-children-affected-by-parental-hiv-aids
#9
Samuele Zilioli, Richard B Slatcher, Peilian Chi, Xiaoming Li, Junfeng Zhao, Guoxiang Zhao
Dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and disruptions of restorative processes (e.g., sleep) have been proposed as two key mechanisms through which loneliness leads to medical morbidity in adults and late adolescents. Whether loneliness acts through these biological and behavioral intermediaries in children as well remains unexplored. In a sample of 645 children aged 8-15 affected by parental HIV/AIDS in rural China, trait and state (i.e., daily) loneliness were measured in a 3-day diary study, wherein participants also provided cortisol samples and sleep measures...
January 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27801949/maternal-prenatal-stress-and-child-atopic-dermatitis-up-to-age-2-years-the-ulm-spatz-health-study
#10
Stefanie Braig, Johannes M Weiss, Tobias Stalder, Clemens Kirschbaum, Dietrich Rothenbacher, Jon Genuneit
BACKGROUND: Evidence linking maternal psychosocial stress during pregnancy to subsequent child atopic dermatitis (AD) is growing but the definition of AD is diverse and results are inconsistent. We aimed to analyze the relationship between stress and AD using alternative methods of measurement of stress and AD. METHODS: In the Ulm SPATZ Health Study, chronic stress and symptoms of anxiety and depression were assessed by standardized self-reported questionnaires in 934 mothers of singletons following delivery in Ulm, Germany, from 04/2012-05/2013...
November 1, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27798546/evaluation-of-early-corticosteroid-therapy-in-management-of-pediatric-septic-shock-in-pediatric-intensive-care-patients-a-randomized-clinical-study
#11
Ahmed El-Nawawy, Doaa Khater, Heba Omar, Yasser Wali
BACKGROUND: Septic shock is a major healthcare problem. Adrenal insufficiency in children with septic shock is a recognized complication, yet is controversial regarding its management and effect on mortality. According to the current guidelines, children with risk factors for adrenal insufficiency should receive a stress dose of steroids in step 3 of treatment. This study aimed to evaluate and compare early corticosteroid therapy with the traditional use of steroids among pediatric septic shock patients...
October 25, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27787408/chronic-psychosocial-stress-and-gut-health-in-children-associations-with-calprotectin-and-fecal-short-chain-fatty-acids
#12
Nathalie Michels, Tom Van de Wiele, Stefaan De Henauw
OBJECTIVES: The mechanisms underpinning the association between chronic stress and gut health are poorly understood. We aimed to investigate the relationship between bacterial produced short-chain fatty acids, gut barrier function, and stress measures. METHODS: A fecal sample, hair sample, and questionnaire data were collected from 113 Belgian children (8-16 years old). Biological measures of stress included hair cortisol (most proximal 3 cm) and 5-minute heart rate variability (high frequency)...
October 26, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27774721/altered-brain-network-integrity-after-childhood-maltreatment-a-structural-connectomic-dti-study
#13
V B Puetz, D Parker, N Kohn, B Dahmen, R Verma, K Konrad
Childhood maltreatment is associated with alterations in neural architecture that potentially put these children at increased risk for psychopathology. Alterations in white matter (WM) tracts have been reported, however no study to date has investigated WM connectivity in brain networks in maltreated children to quantify global and local abnormalities through graph theoretical analyses of DTI data. We aimed for a multilevel investigation examining the DTI-based structural connectome and its associations with basal cortisol levels of 25 children with documented maltreatment experiences before age 3, and 24 matched controls (age: 10...
October 24, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27774583/cortisol-stress-responses-and-children-s-behavioral-functioning-at-school
#14
Sterre S H Simons, Antonius H N Cillessen, Carolina de Weerth
The present study investigated whether cortisol stress responses of 6-year-olds were associated with their behavioral functioning at school. Additionally, the moderating role of stress in the family environment was examined. To this end, 149 healthy children (Mage  = 6.09 years; 70 girls) participated in an age-appropriate innovative social evaluative stress test. Saliva cortisol samples were collected six times during the stress test to calculate two indices of the cortisol stress response: cortisol stress reactivity and total stress cortisol...
October 24, 2016: Developmental Psychobiology
https://www.readbyqxmd.com/read/27771566/prenatal-maternal-cortisol-concentrations-predict-neurodevelopment-in-middle-childhood
#15
Elysia Poggi Davis, Kevin Head, Claudia Buss, Curt A Sandman
Glucocorticoids (cortisol in humans) are the end product of the hypothalamic-pituitary-adrenocortical (HPA) axis and are proposed as a key mechanism for programming fetal brain development. The present prospective longitudinal study evaluates the association between prenatal maternal cortisol concentrations and child neurodevelopment. Participants included a low risk sample of 91 mother-child pairs. Prenatal maternal plasma cortisol concentrations were measured at 19 and 31 gestational weeks. Brain development and cognitive functioning were assessed when children were 6-9 years of age...
January 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27769289/effects-of-oily-fish-intake-on-cardiovascular-risk-markers-cognitive-function-and-behavior-in-school-aged-children-study-protocol-for-a-randomized-controlled-trial
#16
Camilla T Damsgaard, Lotte Lauritzen, Hanne Hauger, Stine Vuholm, Marie N Teisen, Christian Ritz, Max Hansen, Janni Niclasen, Christian Mølgaard
BACKGROUND: Most children in Western populations do not meet recommendations for fish consumption. Oily fish is an important source of n-3 long-chain polyunsaturated fatty acids (LCPUFA), which reduce blood pressure and plasma triacylglycerol in adults and may affect cognitive development and behavior. However, to our knowledge, the potential effects of oily fish on cardiometabolic health, cognitive function, and behavior in children have not been investigated. The aim of the FiSK Junior study is to investigate the effects of oily fish consumption on cardiovascular risk markers, cognitive function, and behavior in healthy children...
October 21, 2016: Trials
https://www.readbyqxmd.com/read/27766109/adrenal-suppression-in-children-treated-with-swallowed-fluticasone-and-oral-viscous-budesonide-for-eosinophilic-esophagitis
#17
Alexandra Ahmet, Eric I Benchimol, Ellen B Goldbloom, Janice L Barkey
BACKGROUND: Adrenal suppression (AS), a glucocorticoid (GC) side effect associated with significant morbidity, is well described related to inhaled corticosteroid therapy for asthma. Swallowed topical glucocorticoid therapy is the main pharmacotherapy treatment for eosinophilic esophagitis (EoE) and therefore children with EoE are potentially at increased risk of AS. METHODS: In this prospective cohort study, we included children and youth <18 years diagnosed with EoE and treated with swallowed fluticasone or oral viscous budesonide for more than 1 month...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27754123/os-24-04-a-pilot-study-assessing-the-feasibility-of-vascular-function-in-low-socioeconomic-status-preschool-children
#18
Lama Ghazi, Tanja Dudenbostel, Deborah Ejem, Anne Turner-Henson, Cynthia Irwin Joiner, Olivia Affuso, Andres Azuero, David A Calhoun, Marti Rice, Fadi Hage, Suzanne Oparil
OBJECTIVE: To assess the feasibility of measuring non-invasively central aortic blood pressure (BP) and indices of arterial stiffness (aortic augmentation index (AIx) and pulse wave velocity (PWV)) in 3-5 year old children and assess if vascular function is affected by vascular inflammation (Serum C-reactive protein (CRP)) and /or cortisol. DESIGN AND METHOD: Central BP, AIx, and PWV were measured using applanation tonometry (SphygmoCor) in 16 children recruited from Head Start centers in AL...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27751767/immunohistochemistry-of-aldosterone-synthase-leads-the-way-to-the-pathogenesis-of-primary-aldosteronism
#19
Koshiro Nishimoto, Minae Koga, Tsugio Seki, Kenji Oki, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez, Mitsuhide Naruse, Tomokazu Sakaguchi, Shinya Morita, Takeo Kosaka, Mototsugu Oya, Tadashi Ogishima, Masanori Yasuda, Makoto Suematsu, Yasuaki Kabe, Masao Omura, Tetsuo Nishikawa, Kuniaki Mukai
Our group previously purified human and rat aldosterone synthase (CYP11B2 and Cyp11b2, respectively) from their adrenals and verified that it is distinct from steroid 11β-hydroxylase (CYP11B1 or Cyp11b1), the cortisol- or corticosterone-synthesizing enzyme. We now describe their distributions immunohistochemically with specific antibodies. In rats, there is layered functional zonation with the Cyp11b2-positive zona glomerulosa (ZG), Cyp11b1-positive zona fasciculata (ZF), and Cyp11b2/Cyp11b1-negative undifferentiated zone between the ZG and ZF...
October 14, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27751222/-changes-in-serum-cortisol-and-adrenocorticotropic-hormone-in-children-with-sepsis-shock-and-their-clinical-significance
#20
Hai Lin, Zi-Jing Wang, Shi-Biao Wang, Yu-Lan Kang
OBJECTIVE: To study the changes in serum levels of cortisol and adrenocorticotropic hormone (ACTH) in children with septic shock (SS) and to explore their relationship with the disease severity and prognosis. METHODS: Twenty-five children with decompensated SS and 24 children with early SS were enrolled. Serum cortisol and ACTH levels were determined on admission and days 3 and 8 after admission. Twenty-five healthy children were used as the control group. The children with decompensated SS were further divided into death group (n=5) and survival group (n=20) based on their clinical outcome...
October 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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