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https://www.readbyqxmd.com/read/29155118/patterns-of-neuroendocrine-coupling-in-9-year-old-children-effects-of-sex-body-mass-index-and-life-stress
#1
Sarah R Black, Matthew D Lerner, Elizabeth A Shirtcliff, Daniel N Klein
Previous investigations have explored stress and pubertal hormones in parallel; it has been a recent development, however, to explore the relationships between different hormones during puberty, and how this hormonal cross-talk may be influenced by the environment. The current study investigated neuroendocrine coupling, or the extent to which hormones are correlated within the individual, and also investigated early life stressors that may influence coupling. Participants were 405 adrenarcheal children (mean Tanner stage=1...
November 16, 2017: Biological Psychology
https://www.readbyqxmd.com/read/29154569/the-social-transmission-of-risk-maternal-stress-physiology-synchronous-parenting-and-well-being-mediate-the-effects-of-war-exposure-on-child-psychopathology
#2
Galit Halevi, Amir Djalovski, Yaniv Kanat-Maymon, Karen Yirmiya, Orna Zagoory-Sharon, Lee Koren, Ruth Feldman
While chronic early stress increases child susceptibility to psychopathology, risk and resilience trajectories are shaped by maternal social influences whose role requires much further research in longitudinal studies. We examined the social transmission of risk by assessing paths leading from war-exposure to child symptoms as mediated by 3 sources of maternal social influence; stress physiology, synchronous parenting, and psychiatric disorder. Mothers and children living in a zone of continuous war were assessed in early childhood (1...
November 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29151100/correlation-between-cosyntropin-stimulation-study-and-disease-severity-in-children-with-fluid-and-catecholamine-refractory-shock-in-the-pediatric-and-cardiovascular-intensive-care-unit
#3
Pallavi Iyer, Brittany Harrington, Jeffrey J Fadrowski, Erica Sibinga, Ernest K Amankwah
BACKGROUND: The cosyntropin stimulation study (CSS) measures the patient's ability to adequately mount a cortisol response. Clinically, CSS results may not be used to guide hydrocortisone use. The objective of this study was to examine how the CSS results are associated with clinical parameters, mortality/disease severity, and use of glucocorticoids in pediatric patients with catecholamine- and fluid-resistant shock. METHODS: This was a retrospective cohort study of patients who had a CSS during 2009-2014 in the intensive care unit at a children's hospital...
November 17, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29115672/peer-problems-among-postinstitutionalized-internationally-adopted-children-relations-to-hypocortisolism-parenting-quality-and-adhd-symptoms
#4
Clio E Pitula, Carrie E DePasquale, Shanna B Mliner, Megan R Gunnar
Seventy-eight postinstitutionalized (PI) children adopted at ages 17-36 months were assessed 2, 8, 16, and 24 months postadoption on measures of cortisol and parenting quality, and compared to same-aged children adopted from foster care (FC, n = 45) and nonadopted children (NA, n = 45). In kindergarten (Mage  = 6.0 years), teachers, parents, and trained observers completed measures of peer relationships and attention deficit hyperactivity disorder (ADHD) symptoms. PI children had more peer problems and ADHD symptoms according to teachers and observers than NA children with FC children in between, whereas both PI and FC children were at significantly greater risk of hypocortisolism (i...
November 8, 2017: Child Development
https://www.readbyqxmd.com/read/29112905/determinants-of-hair-cortisol-concentration-in-children-a-systematic-review
#5
REVIEW
N A Gray, A Dhana, L Van Der Vyver, J Van Wyk, N P Khumalo, D J Stein
BACKGROUND: Several factors are known contribute to hair cortisol concentration (HCC) in adults. However, there is less research on determinants of HCC in children and adolescents. HCC is a valuable tool for medical research pertaining to the hypothalamic-pituitary-adrenal (HPA) axis. This review aims to assess the extent to which established determinants of HCC in adults have been consistently reported in children (birth - 18 years) and to identify determinants of HCC specific to this age group...
November 2, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29106702/hypothalamic-pituitary-adrenal-hpa-axis-suppression-after-treatment-with-glucocorticoid-therapy-for-childhood-acute-lymphoblastic-leukaemia
#6
REVIEW
Niki Rensen, Reinoud Jbj Gemke, Elvira C van Dalen, Joost Rotteveel, Gertjan Jl Kaspers
BACKGROUND: Glucocorticoids play a major role in the treatment of acute lymphoblastic leukaemia (ALL). However, supraphysiological doses can suppress the hypothalamic-pituitary-adrenal (HPA) axis. HPA axis suppression resulting in reduced cortisol response may cause an impaired stress response and an inadequate host defence against infection, which remain a cause of morbidity and death. Suppression commonly occurs in the first days after cessation of glucocorticoid therapy, but the exact duration is unclear...
November 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29102026/amygdala-reward-reactivity-mediates-the-association-between-preschool-stress-response-and-depression-severity
#7
Michael S Gaffrey, Deanna M Barch, Ryan Bogdan, Katrina Farris, Steven E Petersen, Joan L Luby
BACKGROUND: Research in adolescents and adults has suggested that altered neural processing of reward following early life adversity is a highly promising depressive intermediate phenotype. However, very little is known about how stress response, neural processing of reward, and depression are related in very young children. The present study examined the concurrent associations between cortisol response following a stressor, functional brain activity to reward, and depression severity in children 4 to 6 years old...
September 7, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29092084/hormonal-correlates-and-predictors-of-nutritional-recovery-in-malnourished-african-children
#8
Helen M Nabwera, Robin M Bernstein, Schadrac C Agbla, Sophie E Moore, Momodou K Darboe, Mariama Colley, Amadou T Jallow, Richard Bradbury, Jennifer Karafin, Anthony J Fulford, Andrew M Prentice
Background: Malnourished children show variable growth responses to nutritional rehabilitation. We aimed to investigate whether these differences could be explained by variations in growth and energy-regulating hormones. Methods: Quasi-experimental study: Children aged 6-24 months in rural Gambia were recruited to controls if weight-for-height z-score (WHZ) > -2 (n = 22), moderate acute malnutrition if WHZ < -2 and > -3 (n = 18) or severe acute malnutrition if WHZ < -3 (n = 20)...
October 30, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29071821/chinese-pediatric-reference-intervals-for-serum-cortisol-on-immulite-2000
#9
Ling Li Wang, Li Yue Zhang, Hui Yan Wang, Huai Kai Wen, Hong Qun Tao, Xiao Wei Zhao
Clinical interpretation of the test results for cortisol based on continuous reference intervals with appropriate partitions improves pediatric diagnosis; however, these values are available only for Caucasians. To develop the pediatric reference intervals for Chinese population, we examined the serum cortisol levels in 1,143 healthy Chinese children aged 4-18 years (566 boys and 577 girls), using an IMMULITE 2000 Immunoassay System (Siemens Healthcare GmbH). Phlebotomy was performed at 7-9 a.m. for 284 boys and 287 girls and at 1-3 p...
January 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29065770/salivary-cortisol-reactivity-in-preschoolers-is-associated-with-hair-cortisol-and-behavioral-problems
#10
Katie Kao, Stacey N Doan, Ashley M St John, Jerrold S Meyer, Amanda R Tarullo
The interplay between children's cortisol reactivity to challenge and cumulative cortisol exposure is not well understood. Examining the role of cortisol reactivity in early childhood may elucidate biological mechanisms that contribute to children's chronic physiological stress and behavioral dysregulation. In a sample of 65 preschool-aged children, we examined the relation between children's salivary cortisol reactivity to challenging tasks and their hair cortisol concentration (HCC). While both are biomarkers of the hypothalamic-pituitary-adrenal (HPA) axis, salivary cortisol reactivity reflects an acute cortisol response to a stressor and HCC reflects cumulative cortisol exposure...
October 24, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29062584/adrenal-insufficiency-in-pediatric-eosinophilic-esophagitis-patients-treated-with-swallowed-topical-steroids
#11
Stephanie Hsu, Colleen Wood, Zhaoxing Pan, Haseeb Rahat, Philip Zeitler, David Fleischer, Calies Menard-Katcher, Glenn T Furuta, Dan Atkins
Swallowed topical steroids (STS) are the only effective pharmacological therapy for eosinophilic esophagitis (EoE). Thus far, studies of small populations of EoE patients have reported conflicting results in relation to adrenal insufficiency (AI). We sought to measure AI in a clinical setting in children taking STS for EoE. We performed a quality improvement study of pediatric EoE patients seen in a multidisciplinary clinic, who were treated with STS for at least 3 months. Two hundred twenty-five patients completed questionnaires to assess for signs of AI...
September 1, 2017: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/29058789/sleep-biological-stress-and-health-among-toddlers-living-in-socioeconomically-disadvantaged-homes-a-research-protocol
#12
Monica R Ordway, Lois S Sadler, Craig A Canapari, Sangchoon Jeon, Nancy S Redeker
Healthy sleep is important to behavioral, neurobiological, and physiologic health. In older children and adults, stress biomarkers, such as cortisol and C-reactive protein, increase when they do not practice healthy sleep habits. However, little is known about the relationships among sleep health, stress, and health outcomes among very young children living with socioeconomic adversity, a group that is particularly at risk for poor future health. The NIH-funded study described in this protocol addresses this scientific gap to improve understanding of these relationships during a critical developmental period in children's lives-toddlerhood...
December 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/29048574/community-crime-exposure-and-risk-for-obesity-in-preschool-children-moderation-by-the-hypothalamic-pituitary-adrenal-axis-response
#13
Maria A Gartstein, Erich Seamon, Stephanie F Thompson, Liliana J Lengua
Objective: Identification of early risk factors related to obesity is critical to preventative public health efforts. In this study, we investigated links between the Hypothalamic-Pituitary-Adrenal (HPA)-axis activity (diurnal cortisol pattern), geospatially operationalized exposure to neighborhood crime, and body mass index (BMI) for a sample of 5-year-old children. Greater community crime exposure and lower HPA-axis activity were hypothesized to contribute to higher BMI, with child HPA-axis moderating the association between crime exposure and BMI...
September 18, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29037796/salivary-cortisol-levels-predict-therapeutic-response-to-a-sleep-promoting-method-in-children-with-postural-tachycardia-syndrome
#14
Jing Lin, Huacai Zhao, Jie Shen, Fuyong Jiao
OBJECTIVE: To determine the value of salivary cortisol concentrations in predicting the efficacy of sleep-promoting treatment in children with postural tachycardia syndrome (POTS). STUDY DESIGN: This prospective study involved 40 children with POTS and 20 healthy children (controls). POTS was diagnosed using the head-up or head-up tilt test. Patients with POTS received a sleep-promoting treatment: >8 hours of sleep every night and a midday nap in an appropriate environment; no drinking water or exercising before bedtime; and urination before bedtime...
October 13, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29035709/heart-rate-variability-and-salivary-cortisol-in-very-preterm-children-during-school-age
#15
Natalie Urfer-Maurer, Sebastian Ludyga, Tobias Stalder, Serge Brand, Edith Holsboer-Trachsler, Markus Gerber, Alexander Grob, Peter Weber, Sakari Lemola
The autonomic nervous system (ANS) plays a major role in the human stress response and reflects physical and psychological adaptability to a changing environment. Long-term exposure to early life stressors may alter the function of the ANS. The present study examines differences in the ANS between children born very preterm and full-term as well as the association between the ANS and the hypothalamic-pituitary-adrenal (HPA) axis, the other main branch of the human stress system. Fifty-four healthy children born very preterm (<32nd gestational week) and 67 full-term children aged 7-12 years provided data for the present study...
October 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29032322/classroom-social-experiences-in-early-elementary-school-relate-to-diurnal-cortisol-levels
#16
Pia Behnsen, Marieke Buil, Susanne Koot, Anja Huizink, Pol van Lier
Social stress has been linked to altered hypothalamic-pituitary-adrenocorticol (HPA) axis activation. During elementary school, children can become exposed to negative peer relations, such as poor appraisal among classroom peers, which is considered a social stressor. However, little is known about the association between classroom peer appraisal and the physiological stress system in children. The goal of this study was to examine the association of peer acceptance and peer non-acceptance with diurnal cortisol concentrations in 222 children from 20 mainstream elementary schools (Mage=6...
October 2, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29030905/comparing-the-effects-of-age-pubertal-development-and-symptom-profile-on-cortisol-rhythm-in-children-and-adolescents-with-autism-spectrum-disorder
#17
Rachael A Muscatello, Blythe A Corbett
Previous studies in children with autism spectrum disorder (ASD) have shown elevated evening cortisol; however, few studies have examined diurnal rhythm in adolescents with ASD. Adolescence is a time of significant physical and psychological change, and dysregulation of the hypothalamic-pituitary-adrenal axis may put adolescents with ASD at increased risk for internalizing disorders, such as anxiety and depression. The extent to which cortisol levels are associated with age, puberty and symptom profile was examined in 113 youth (ages 7-17) with ASD and typical development...
October 14, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29019550/salivary-stress-biomarkers-and-anxiety-symptoms-in-children-with-and-without-temporomandibular-disorders
#18
Fernanda Yukie Kobayashi, Maria Beatriz Duarte Gavião, Maria Carolina Salomé Marquezin, Fernando Luiz Affonso Fonseca, Ana Bheatriz Marangoni Montes, Taís de Souza Barbosa, Paula Midori Castelo
The etiology of temporomandibular disorders (TMD), which are considered as a heterogeneous group of psychophysiological disturbances, remains a controversial issue in clinical dentistry. This study aimed to evaluate whether the salivary alpha-amylase (sAA), cortisol levels, and anxiety symptoms differ between children with and without TMD. Initially, 316 young subjects were screened in public schools (nonreferred sample); 76 subjects aged 7-14 years were selected and comprised the TMD and control groups with 38 subjects each matched by sex, age, and the presence/absence of sleep bruxism...
September 28, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/29017438/hsd11b2-runx3-and-line-1-methylation-in-placental-dna-of-hypertensive-disorders-of-pregnancy-patients
#19
Aleksandra Majchrzak-Celińska, Katarzyna Kosicka, Julia Paczkowska, Franciszek K Główka, Grzegorz H Bręborowicz, Mariola Krzyścin, Anna Siemiątkowska, Marcin Szaumkessel, Wanda Baer-Dubowska
Hypertensive Disorders of Pregnancy (HDsP) remain leading causes of maternal and perinatal morbidity and mortality. Growing evidence suggests the involvement of epigenetic factors, such as gene-specific and global DNA methylation changes, both in the etiology and as an effect of HDsP. In this study, we investigated the potential association between placental DNA methylation status in selected CpGs of HSD11B2 cortisol level controlling gene, RUNX3 tumor suppressor gene, and long interspersed nucleotide element-1 (LINE-1) repetitive elements and HDsP-preeclampsia (PE), gestational hypertension (GH), and chronic hypertension (CH)...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28992603/sex-steroid-hormones-and-sex-hormone-binding-globulin-levels-cyp17-msp-ai-34t-c-and-cyp19-codon-39-trp-arg-variants-in-children-with-developmental-stuttering
#20
Hiwa Mohammadi, Mohammad Taghi Joghataei, Zohreh Rahimi, Faezeh Faghihi, Habibolah Khazaie, Hashem Farhangdoost, Masoud Mehrpour
Developmental stuttering is known to be a sexually dimorphic and male-biased speech motor control disorder. In the present case-control study, we investigated the relationship between developmental stuttering and steroid hormones. Serum levels of testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), oestradiol, progesterone, cortisol, and sex hormone binding globulin (SHBG), as well as the 2nd/4th digit ratio (2D:4D), an indicator of prenatal testosterone level, were compared between children who stutter (CWS) and children who do not stutter (CWNS)...
October 6, 2017: Brain and Language
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