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Relational priming

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https://www.readbyqxmd.com/read/29455108/ureaplasma-isolates-differentially-modulate-growth-factors-and-cell-adhesion-molecules-in-human-neonatal-and-adult-monocytes
#1
Kirsten Glaser, Christine Silwedel, Ana Maria Waaga-Gasser, Birgit Henrich, Markus Fehrholz, Heike Claus, Christian P Speer
Generally regarded as commensal bacteria, the pathogenicity of Ureaplasma has often been considered low. Controversy remains concerning the clinical relevance of Ureaplasma infection in the pathogenesis of inflammation-related morbidities. Recently, we demonstrated Ureaplasma-driven pro-inflammatory cytokine responses in human monocytes in vitro. We hypothesized that Ureaplasma may induce further inflammatory mediators. Using qRT-PCR and multi-analyte immunoassay, we assessed the expression of granulocyte-colony stimulating factor (G-CSF), vascular endothelial growth factor (VEGF), intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in term neonatal and adult monocytes exposed to Ureaplasma urealyticum serovar 8 (Uu8) and U...
February 15, 2018: Cytokine
https://www.readbyqxmd.com/read/29454856/nucleosidic-dna-demethylating-epigenetic-drugs-a-comprehensive-review-from-discovery-to-clinic
#2
REVIEW
Khushboo Agrawal, Viswanath Das, Pankhuri Vyas, Marián Hajdúch
DNA methylation plays a pivotal role in the etiology of cancer by mediating epigenetic silencing of cancer-related genes. Since the relationship between aberrant DNA methylation and cancer has been understood, there has been an explosion of research at developing anti-cancer therapies that work by inhibiting DNA methylation. From the discovery of first DNA hypomethylating drugs in the 1980s to recently discovered second generation pro-drugs, exceedingly large number of studies have been published that describe the DNA hypomethylation-based anti-neoplastic action of these drugs in various stages of the pre-clinical investigation and advanced stages of clinical development...
February 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29453255/endophyte-mediated-modulation-of-defense-responsive-genes-and-systemic-resistance-in-withania-somnifera-l-dunal-under-alternaria-alternata-stress
#3
Aradhana Mishra, Satyendra Pratap Singh, Sahil Mahfooz, Surendra Pratap Singh, Arpita Bhattacharya, Nishtha Mishra, C S Nautiyal
Endophytes have been explored to perform an important role in plant health. However, their effects on the host physiological function and disease management remains elusive. The present study was aimed to assess the potential of endophytes singly as well as in combination on various physiological parameters and systemic defense mechanism against Alternaria alternata in Withania somnifera (L.) Dunal. Seed priming with endophytic Bacillus amyloliquefaciens and Pseudomonas fluorescens individually and in combination demonstrated enhanced vigor index and germination rate...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29451817/the-impact-of-pulse-pressure-on-cerebrovascular-events-leading-to-age-related-cognitive-decline
#4
Nathalie Thorin-Trescases, Olivia de Montgolfier, Anthony Pinçon, Adeline Raignault, Laurie Caland, Pauline Labbé, Eric Thorin
Aging is a modern concept: human life expectancy has more than doubled in less than 150 years in Western countries. Longer lifespan, however, reveals age-related diseases, including cerebrovascular diseases. The vascular system is a prime target of aging: the "wear and tear" of large elastic arteries exposed to a life-long pulsatile pressure causes arterial stiffening by fragmentation of elastin fibers and replacement by stiffer collagen. This arterial stiffening increases in return the amplitude of the pulse pressure (PP), its wave penetrating deeper into the microcirculation of low resistance, high flow organs such as the brain...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29450239/alcohol-related-mental-imagery-the-effects-of-a-priming-dose-in-at-risk-drinkers
#5
Michael Yates, Sunjeev K Kamboj
Objectives: Drug related mental imagery is proposed to play a central role in addictive behaviour. However, little is known about such cognition or how it is pharmacologically modulated. Here, we test theoretical predictions of the 'elaborated intrusion' theory by comparing neutral with alcohol related mental imagery, and examine the effects of low dose alcohol on phenomenological aspects of this imagery. Methods: Alcohol related and neutral imagery was assessed after at risk drinkers (n = 40) consumed alcohol (0...
December 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29447251/attention-to-fat-and-thin-related-words-in-body-satisfied-and-body-dissatisfied-women-before-and-after-thin-model-priming
#6
Leah N Tobin, Christopher R Sears, Alicia S Zumbusch, Kristin M von Ranson
Understanding the cognitive processes underlying body dissatisfaction provides important information on the development and perpetuation of eating pathology. Previous research suggests that body-dissatisfied women process weight-related information differently than body-satisfied women, but the precise nature of these processing differences is not yet understood. In this study, eye-gaze tracking was used to measure attention to weight-related words in body-dissatisfied (n = 40) and body-satisfied (n = 38) women, before and after exposure to images of thin fashion models...
2018: PloS One
https://www.readbyqxmd.com/read/29447214/high-efficiency-classification-of-children-with-autism-spectrum-disorder
#7
Genyuan Li, Olivia Lee, Herschel Rabitz
Autism spectrum disorder (ASD) is a wide-ranging collection of developmental diseases with varying symptoms and degrees of disability. Currently, ASD is diagnosed mainly with psychometric tools, often unable to provide an early and reliable diagnosis. Recently, biochemical methods are being explored as a means to meet the latter need. For example, an increased predisposition to ASD has been associated with abnormalities of metabolites in folate-dependent one carbon metabolism (FOCM) and transsulfuration (TS)...
2018: PloS One
https://www.readbyqxmd.com/read/29446962/borderline-personality-features-and-integration-of-positive-and-negative-thoughts-about-significant-others
#8
Kathy R Berenson, Jessica C Johnson, Fanghui Zhao, Olga Nynaes, Tamir Goren
Taking the bad with the good is a necessity of life, and people who readily integrate thoughts of their loved one's flaws with thoughts of their more positive attributes maintain more stable, satisfying relationships. Borderline personality disorder, however, is often characterized by interpersonal perceptions that fluctuate between extremes of good and bad. We used a timed judgment task to examine information processing about significant others in individuals high in borderline personality features relative to healthy individuals and those high in avoidant personality features...
February 15, 2018: Personality Disorders
https://www.readbyqxmd.com/read/29444126/applying-the-multi-threat-framework-of-stereotype-threat-in-the-context-of-digital-gaming
#9
Charlotte R Pennington, Linda K Kaye, Joseph J McCann
Females often report experiencing stigmatisation pertaining to their competency in digital gaming communities. Employing the principles of the multi-threat framework of stereotype threat, the current research examined the impact of gender-related stereotypes on females' gaming performance and related self-perceptions. In Experiment 1, 90 females were assigned to one of three conditions in which they were primed that their performance would be either diagnostic of their personal (self-as-target) or gender group's ability (group-as-target) or would be non-diagnostic of gaming ability (control)...
2018: PloS One
https://www.readbyqxmd.com/read/29439210/mycorrhiza-triggered-transcriptomic-and-metabolomic-networks-impinge-on-herbivore-fitness
#10
Moritz Kaling, Anna Schmidt, Franco Moritz, Maaria Rosenkranz, Michael Witting, Karl Kasper, Dennis Janz, Phillipe Schmitt-Kopplin, Joerg-Peter Schnitzler, Andrea Polle
Symbioses between plants and mycorrhizal fungi are ubiquitous in ecosystems and strengthen the plants' defense against aboveground herbivores. Here, we studied the underlying regulatory networks and biochemical mechanisms in leaves induced by ectomycorrhizae that modify herbivore interactions. Feeding damage and oviposition by the widespread poplar leaf beetle Chrysomela populi were reduced on ectomycorrhizal hybrid poplar Populus x canescens. Integration of transcriptomics, metabolomics and volatile emission patterns via mass difference networks demonstrated changes in nitrogen allocation in leaves of mycorrhizal poplars, down-regulation of phenolic pathways and up-regulation of defensive systems, including protease inhibitors, chitinases and aldoxime biosynthesis...
February 8, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29438157/effects-of-varenicline-alone-and-in-combination-with-low-dose-naltrexone-on-alcohol-primed-smoking-in-heavy-drinking-tobacco-users-a-preliminary-laboratory-study
#11
Walter Roberts, Julia M Shi, Jeanette M Tetrault, Sherry A McKee
OBJECTIVES: Heavy-drinking tobacco users are less likely to successfully quit smoking than their moderate-drinking counterparts, even when they are prescribed smoking cessation medication. One strategy for improving treatment outcomes in this subgroup of tobacco users may be to combine medication therapies to target both alcohol and tobacco use simultaneously. Adding naltrexone to frontline smoking cessation treatments may improve treatment outcomes in this group. METHOD: This double-blind, placebo-controlled human laboratory study examined the effects of varenicline (2 mg/d) and varenicline (2 mg/d), combined with a low dose of naltrexone (25 mg/d) on alcohol-primed smoking behavior in a laboratory model of smoking relapse in heavy-drinking tobacco users (n = 30)...
February 12, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29436231/wavelength-dependent-optical-force-imaging-of-bimetallic-al-au-heterodimers
#12
Thejaswi Tumkur, Xiao Yang, Chao Zhang, Jian Yang, Yue Zhang, Gururaj V Naik, Peter Nordlander, Naomi J Halas
Many important applications of nanometer-scale metallic complexes arise from the light-induced, near-field interactions between their component structures. Here we examine the near-field interactions in bimetallic Al-Au plasmonic nanodisk heterodimers, where the coupling between the primitive plasmons of nanostructures composed of two different metals is studied. Understanding the correlations between nanoparticle morphology and near-field optical properties, particularly for nanostructures composed of two different metals, requires spectrally resolved near-field spatial information...
February 13, 2018: Nano Letters
https://www.readbyqxmd.com/read/29436215/organelle-targeting-gold-nanorods-for-macromolecular-profiling-of-subcellular-organelles-and-enhanced-cancer-cell-killing
#13
Yanting Shen, Lijia Liang, Shuqin Zhang, Dianshuai Huang, Rong Deng, Jing Zhang, Huixin Qu, Shuping Xu, Chongyang Liang, Weiqing Xu
Subcellular organelles, e.g., nucleus, mitochondria and lysosome, are the vital organelles with responsibilities that maintain cell operation and metabolism. Owing to their roles in energy production and programmed cell death, these organelles have become prime therapeutic targets in different diseases and states. In this study, biocompatible, organelle-targeting nanoprobes were developed by modifying gold nanorods (AuNRs) with specific targeting peptides. These nanoprobes were employed to directly profile subcellular biomolecules and vital organelles in situ by surface-enhanced Raman scattering (SERS) spectroscopy...
February 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29435339/perceptions-regarding-utilization-of-meteorological-information-in-healthcare-in-korea-a-qualitative-study
#14
Minsu Ock, Eun Young Choi, Inbo Oh, Seok Hyeon Yun, Yoo-Keun Kim, Hyunsu Kim, Min-Woo Jo, Jiho Lee
Background: Health forecasting has been used in an attempt to provide timely and tailored meteorological information to patients and healthcare providers so that they might take appropriate actions to mitigate health risks and manage healthcare-related needs. This study examined the in-depth perceptions of healthcare providers and the general public regarding the utilization of meteorological information in the healthcare system in Korea. Methods: The COREQ (Consolidated Criteria for Reporting Qualitative Research) checklist was applied to this study...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29434430/microshear-bond-strength-of-self-adhesive-composite-to-ceramic-after-mechanical-chemical-and-laser-surface-treatments
#15
Maryam Ghavam, Marjan Soleimanpour, Sedighe Sadat Hashemikamangar, Hooman Ebrahimi, Mohammad Javad Kharazifard
Objectives: This study aimed to assess the microshear bond strength of a repairing self-adhesive flowable composite to ceramic after mechanical, chemical and laser treatment of the ceramic surface. Materials and Methods: Forty zirconia and forty feldspathic ceramic blocks measuring 8 x 8 x 2 mm were fabricated. Feldspathic blocks were divided into four groups of control (1), laser (2780 nm) (2), sandblasting + hydrofluoric (HF) acid + silane (3) and laser (2780 nm) + HF acid + silane (4)...
December 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29431452/smoking-by-young-women-with-restrained-eating-following-a-food-prime-in-the-context-of-an-alternative-distractor
#16
Michelle A Kovacs, Amanda M Palmer, John B Correa, Thomas H Brandon
Female smokers with elevated dietary restraint (high restrainers) may smoke more than nonrestrained eaters after a disinhibiting food event. The current study aimed to determine whether high restrainers smoke merely to distract themselves from unplanned eating or whether the weight-control aspects of smoking play a role. Primary aims were to test the effect of restraint status and a food prime on smoking and eating behavior in the presence of an alternative distractor (a computer tablet) and to examine the role of expectancies...
February 12, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29429815/long-term-immunogenicity-of-an-initial-booster-dose-of-an-inactivated-vero-cell-culture-derived-japanese-encephalitis-vaccine-je-vc-and-the-safety-and-immunogenicity-of-a-second-je-vc-booster-dose-in-children-previously-vaccinated-with-an-inactivated-mouse
#17
Ki Wook Yun, Hoan Jong Lee, Ji Young Park, Hye-Kyung Cho, Yae-Jean Kim, Kyung-Hyo Kim, Nam Hee Kim, Young Jin Hong, Dong Ho Kim, Hwang Min Kim, Sung-Ho Cha
BACKGROUND: This study was performed with the aim of determining the long-term immunogenicity of an inactivated, Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) and an inactivated, mouse brain-derived JE vaccine (JE-MB) after the 1st booster dose at 2 years of age, as well as the safety and immunogenicity of the 2nd booster dose of JE-VC at 6 years of age, in children primed and given a 1st booster dose of either JE-VC or JE-MB. METHOD: In this multicenter, open-label clinical trial, the study population consisted of healthy Korean children (aged 6 years) who participated in the previous JE vaccine trial...
February 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29428145/his-bundle-pacing-is-it-ready-for-prime-time
#18
REVIEW
Fatima M Ezzeddine, Gopi Dandamudi
Long-term right ventricular apical pacing has been associated with detrimental effects, including an increased risk for heart failure, atrial fibrillation, and death. Most of these adverse effects result from ventricular dyssynchrony related to perturbed ventricular depolarization. In addition, biventricular pacing has limited benefits in patients with non-left bundle branch block and severely reduced ejection fraction. Consequently, alternative pacing strategies that mimic natural physiology are desired. Recently, permanent His bundle pacing has emerged as a true physiologic form of ventricular pacing that has been shown to be safe and feasible in clinical practice...
March 2018: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/29426787/direct-object-pronoun-sentence-processing-in-spanish-english-children-with-without-specific-language-impairment-and-adults-a-cross-modal-priming-study
#19
Dolors Girbau
PURPOSE: This paper examines whether bilingual children with Specific Language Impairment (SLI) showed limited comprehension of Direct Object (DO) pronoun sentences and/or morphosyntactic priming compared to children with Typical Language Development (TLD) and adults. We analyzed the relation of these morphosyntactic processes to other psycholinguistic abilities, according to the MUC (Memory-Unification-Control) model. METHOD: Ten bilingual native Spanish-speaking children with SLI (8;3-10;6) and 10 age-matched children with TLD (7;6-10;10) received a psycholinguistic evaluation in Spanish-English...
February 2, 2018: Journal of Communication Disorders
https://www.readbyqxmd.com/read/29420758/moulds-associated-with-contaminated-ocular-and-injectable-drugs-fda-recalls-epidemiology-considerations-drug-shortages-and-aseptic-processing
#20
Donald G Ahearn, R Doyle Stulting
Recent (2012) grave but rare outbreaks of fungal meningitis and endophthalmitis associated with drugs contaminated with select environmental moulds (Exserohilum and Fusarium, respectively) have exacerbated mycology concerns for formulation, good laboratory practices (GLP), and use of the final drug product. Intensified investigations (2013-2015) by the Food and Drug Administration (FDA) that included added responsibilities for specialty compounding laboratories have prompted at least nine voluntary mould-related drug recalls during 2014-2015...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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