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Relational priming

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https://www.readbyqxmd.com/read/29236127/-basic-knowledge-on-the-efficacy-of-hearing-aids-depending-on-the-type-of-hearing-impairment-for-ear-nose-throat-specialists
#1
REVIEW
T Steffens, S C Marcrum
For Ear, Nose & Throat specialists, the physiological and psychoacoustical deficits related to hearing impairment and the compensatory capabilities of hearing aids are topics of prime importance. In conductive hearing loss, the foremost deficit is decreased audibility, for which hearing aids can compensate almost entirely through the use of level independent gain. In the instance of sensorineural hearing loss, however, the irreversible loss of outer and inner hair cells causes a distorted sound perception, which is particularly troublesome when trying to understand speech in noisy environments...
December 13, 2017: HNO
https://www.readbyqxmd.com/read/29234754/durability-of-resin-bonding-to-lithium-disilicate-and-zirconia-ceramic-using-a-self-etching-primer
#2
Sebastian Wille, Frank Lehmann, Matthias Kern
PURPOSE: The purpose of this in vitro study was twofold: 1. To evaluate the surface conditioning effect of a self-etching ceramic primer on lithium disilicate and zirconia ceramics; (2) to study the bond durability provided by the self-etching ceramic primer after artificial aging compared with conventional ceramic conditioning methods. MATERIALS AND METHODS: Lithium disilicate blocks (10 × 10 mm, 3.4 mm thick) and zirconia disks (8 mm diameter, 3.4 mm thick) were each divided into two groups...
December 12, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/29232653/salicylic-acid-and-broad-spectrum-of-nbs-lrr-family-genes-are-involved-in-smv-soybean-interactions
#3
Qiqi Zhao, Haina Li, Hongyu Sun, Aoga Li, Shuxin Liu, Ruonan Yu, Xiuqi Cui, Dejian Zhang, Hada Wuriyanghan
Soybean mosaic virus (SMV) is a severe pathogen reducing crop yield and seed quality of soybean. Although several resistance gene loci including Rsv1, Rsv3 and Rsv4 are identified in some soybean varieties, most of the soybean genes related to SMV infection are still not characterized. In order to reveal genome-wide gene expression profiles in response to SMV infection, we used transcriptome analysis to determine SMV-responsive genes in susceptible variety Hefeng25. Time course RNA-seq analysis at 1, 5 and 10 dpi identified many deregulated pathways and gene families...
December 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29232316/prime-a-novel-low-mass-high-repetition-approach-to-improve-function-in-older-adults
#4
Jason D Allen, Mitch D VanBruggen, Neil M Johannsen, Jennifer L Robbins, Daniel P Credeur, Carl F Pieper, Richard Sloane, Conrad P Earnest, Timothy S Church, Eric Ravussin, William E Kraus, Michael A Welsch
INTRODUCTION: The ability to maintain functional independence in a rapidly aging population results in an increased life expectancy without corresponding increases in health care costs. The accelerated decline in VO2peak after the age of 65 is primarily due to peripheral tissue changes rather than centrally mediated factors. The purpose of this study was to determine if the PRIME (Peripheral Remodeling through Intermittent Muscular Exercise) approach, consisting of a low mass, high repetition/duration skeletal muscle focused training regimen would provide superior functional benefits in participants above 70 years old and at risk for losing functional independence...
December 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29230199/resource-legacies-of-organic-and-conventional-management-differentiate-soil-microbial-carbon-use
#5
Melissa M Arcand, David J Levy-Booth, Bobbi L Helgason
Long-term contrasts in agricultural management can shift soil resource availability with potential consequences to microbial carbon (C) use efficiency (CUE) and the fate of C in soils. Isothermal calorimetry was combined with 13C-labeled glucose stable isotope probing (SIP) of 16S rRNA genes to test the hypothesis that organically managed soils would support microbial communities with greater thermodynamic efficiency compared to conventional soils due to a legacy of lower resource availability and a resultant shift toward communities supportive of more oligotrophic taxa...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29229010/relative-importance-of-phosphatidylinositol-3-kinase-pi3k-akt-and-mitogen-activated-protein-kinase-mapk3-1-signaling-during-maturational-steroid-induced-meiotic-g2-m1-transition-in-zebrafish-oocytes
#6
Debabrata Das, Poulomi Nath, Soumojit Pal, Sudip Hajra, Pritha Ghosh, Sudipta Maitra
Participation and relative importance of phosphatidylinositol-3 kinase (PI3K) and mitogen-activated protein kinase (MAPK) signalling, either alone or in combination, have been investigated during 17α,20β-dihydroxy-4-pregnen-3-one (DHP)-induced meiotic G2-M1 transition in denuded zebrafish oocyte. Results demonstrate that concomitant with rapid phosphorylation (activation) of Akt (Ser473) and MAPK (ERK1/2) at as early as 15 min of incubation, DHP stimulation promotes enhanced an GVBD response and histone H1 kinase activation between 1 and 5 h in full-grown oocytes in vitro...
December 12, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/29225210/inhibitory-role-of-munc13-1-in-antigen-induced-mast-cell-degranulation
#7
Hironori Higashio, Yoh-Ichi Satoh, Tomoyuki Saino
Secretory granules (SGs) of mast cells are lysosome-related organelles that contain various inflammatory molecules such as histamine, which are stored in the cytoplasm. Mast cell degranulation is the regulated exocytosis of SGs in response to external stimuli, such as the antigen-mediated cross-linking of the high-affinity IgE receptor, FcεRI. Upon stimulation, SGs undergo priming to become fusion-competent prior to fusing with the plasma membrane, which is mediated by Munc13-4, one of the five members of the vesicle-priming Munc13 protein family...
2017: Biomedical Research
https://www.readbyqxmd.com/read/29223621/does-observation-of-a-disabled-child-s-action-moderate-action-execution-implication-for-the-use-of-action-observation-therapy-for-patient-rehabilitation
#8
Marie Alsamour, Maxime Gilliaux, Anne Renders, Thierry Lejeune, Gaëtan Stoquart, Martin Gareth Edwards
BACKGROUND: Research investigating action observation-execution priming has mainly manipulated congruent versus incongruent action, and aspects of action expertise/capability. More specifically, the literature suggests enhanced performance priming following action observation by actors closely matched to participant expertise. The aim of the present study was to extend the understanding of action expertise effects by investigating action priming in healthy participants after observing a mild hemiparetic child actor versus a neurologically healthy child actor...
November 15, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29222513/biotrophy-necrotrophy-switch-in-pathogen-evoke-differential-response-in-resistant-and-susceptible-sesame-involving-multiple-signaling-pathways-at-different-phases
#9
Supriyo Chowdhury, Arpita Basu, Surekha Kundu
Infection stages of charcoal rot fungus Macrophomina phaseolina in sesame revealed for the first time a transition from biotrophy via BNS (biotrophy-to-necrotrophy switch) to necrotrophy as confirmed by transcriptional studies. Microscopy using normal and GFP-expressing pathogen showed typical constricted thick intercellular bitrophic hyphae which gave rise to thin intracellular necrotrophic hyphae during BNS and this stage was delayed in a resistant host. Results also show that as the pathogen switched its strategy of infection, the host tailored its defense strategy to meet the changing situation...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222491/exploring-biased-attention-towards-body-related-stimuli-and-its-relationship-with-body-awareness
#10
Gerardo Salvato, Gabriele De Maio, Gabriella Bottini
Stimuli of great social relevance exogenously capture attention. Here we explored the impact of body-related stimuli on endogenous attention. Additionally, we investigate the influence of internal states on biased attention towards this class of stimuli. Participants were presented with a body, face, or chair cue to hold in memory (Memory task) or to merely attend (Priming task) and, subsequently, they were asked to find a circle in an unrelated visual search task. In the valid condition, the circle was flanked by the cue...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222172/proximal-aberrant-crypt-foci-associate-with-synchronous-neoplasia-and-are-primed-for-neoplastic-progression
#11
David A Drew, Allen Mo, James J Grady, Richard G Stevens, Joel B Levine, Bruce M Brenner, Joseph C Anderson, Faripour Forouhar, Michael J O'Brien, Thomas J Devers, Daniel W Rosenberg
Aberrant crypt foci (ACF) are the earliest morphologically identifiable lesion found within the human colon. Despite their relatively high frequency in the distal colon, few studies have examined the molecular characteristics of ACF within the proximal colon. In the following study, clinical participants (n=184) were screened for ACF using high-definition chromoendoscopy with contrast dye-spray. Following pathological confirmation, ACF biopsies were subjected to laser-capture microdissection (LCM) and epithelial cells were evaluated for somatic mutations with a customized colorectal cancer mutation panel using DNA-mass spectrometry...
December 8, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29221906/presynaptic-active-zones-of-mammalian-neuromuscular-junctions-nanoarchitecture-and-selective-impairments-in-aging
#12
REVIEW
Yomna Badawi, Hiroshi Nishimune
Neurotransmitter release occurs at active zones, which are specialized regions of the presynaptic membrane. A dense collection of proteins at the active zone provides a platform for molecular interactions that promote recruitment, docking, and priming of synaptic vesicles. At mammalian neuromuscular junctions (NMJs), muscle-derived laminin β2 interacts with presynaptic voltage-gated calcium channels to organize active zones. The molecular architecture of presynaptic active zones has been revealed using super-resolution microscopy techniques that combine nanoscale resolution and multiple molecular identification...
December 5, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29221778/long-term-treatment-with-dopamine-d3-receptor-agonists-induces-a-behavioral-switch-that-can-be-rescued-by-blocking-the-dopamine-d1-receptor
#13
Mai-Lynne Dinkins, Perrine Lallemand, Stefan Clemens
Restless legs syndrome (RLS) is commonly treated with the dopamine agonists pramipexole, and rotigotine, which target the inhibitory dopamine receptor subtype D3R. While initially highly effective, these compounds lose their efficacy in treating RLS over time, and long-term therapy regularly leads to a worsening of the symptoms (augmentation). This dopamine agonist-induced augmentation has become a prime concern in the treatment of RLS, and while alternate therapies are being proposed, the mechanisms leading to augmentation remain opaque...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29219420/sio_-2-glass-density-to-lower-mantle-pressures
#14
Sylvain Petitgirard, Wim J Malfait, Baptiste Journaux, Ines E Collings, Eleanor S Jennings, Ingrid Blanchard, Innokenty Kantor, Alexander Kurnosov, Marine Cotte, Thomas Dane, Manfred Burghammer, David C Rubie
The convection or settling of matter in the deep Earth's interior is mostly constrained by density variations between the different reservoirs. Knowledge of the density contrast between solid and molten silicates is thus of prime importance to understand and model the dynamic behavior of the past and present Earth. SiO_{2} is the main constituent of Earth's mantle and is the reference model system for the behavior of silicate melts at high pressure. Here, we apply our recently developed x-ray absorption technique to the density of SiO_{2} glass up to 110 GPa, doubling the pressure range for such measurements...
November 24, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29216926/pro-inflammatory-adjuvant-properties-of-pigment-grade-titanium-dioxide-particles-are-augmented-by-a-genotype-that-potentiates-interleukin-1%C3%AE-processing
#15
Sebastian Riedle, Laetitia C Pele, Don E Otter, Rachel E Hewitt, Harjinder Singh, Nicole C Roy, Jonathan J Powell
BACKGROUND: Pigment-grade titanium dioxide (TiO2) particles are an additive to some foods (E171 on ingredients lists), toothpastes, and pharma-/nutraceuticals and are absorbed, to some extent, in the human intestinal tract. TiO2 can act as a modest adjuvant in the secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β) when triggered by common intestinal bacterial fragments, such as lipopolysaccharide (LPS) and/or peptidoglycan. Given the variance in human genotypes, which includes variance in genes related to IL-1β secretion, we investigated whether TiO2 particles might, in fact, be more potent pro-inflammatory adjuvants in cells that are genetically susceptible to IL-1β-related inflammation...
December 8, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29216330/genome-wide-analysis-of-the-brachypodium-distachyon-l-p-beauv-hsp90-gene-family-reveals-molecular-evolution-and-expression-profiling-under-drought-and-salt-stresses
#16
Ming Zhang, Zhiwei Shen, Guoqing Meng, Yu Lu, Yilei Wang
The structure, evolution, and function of heat shock proteins 90 (Hsp90s) have been investigated in great detail in fungi and animals. However, studies on the Hsp90 genes in plants are generally limited. Brachypodium distachyon (L.) P. Beauv., as a model plant for cereal crops, has become a potential biofuel grass. During its long evolution, the Hsp90 gene family in Brachypodium has developed some strategies to cope with adverse environments. How the Hsp90 gene family in Brachypodium evolved in different plant lineages and what its role is in plant responses to drought and salt stresses remains to be elucidated...
2017: PloS One
https://www.readbyqxmd.com/read/29215039/semantic-discrimination-impacts-tdcs-modulation-of-verb-processing
#17
Valentina Niccolai, Anne Klepp, Peter Indefrey, Alfons Schnitzler, Katja Biermann-Ruben
Motor cortex activation observed during body-related verb processing hints at simulation accompanying linguistic understanding. By exploiting the up- and down-regulation that anodal and cathodal transcranial direct current stimulation (tDCS) exert on motor cortical excitability, we aimed at further characterizing the functional contribution of the motor system to linguistic processing. In a double-blind sham-controlled within-subjects design, online stimulation was applied to the left hemispheric hand-related motor cortex of 20 healthy subjects...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29213269/safety-and-immunogenicity-of-malaria-vectored-vaccines-given-with-routine-expanded-program-on-immunization-vaccines-in-gambian-infants-and-neonates-a-randomized-controlled-trial
#18
Victorine A Mensah, Sophie Roetynck, Ebrima K Kanteh, Georgina Bowyer, Amy Ndaw, Francis Oko, Carly M Bliss, Ya Jankey Jagne, Riccardo Cortese, Alfredo Nicosia, Rachel Roberts, Flavia D'Alessio, Odile Leroy, Babacar Faye, Beate Kampmann, Badara Cisse, Kalifa Bojang, Stephen Gerry, Nicola K Viebig, Alison M Lawrie, Ed Clarke, Egeruan B Imoukhuede, Katie J Ewer, Adrian V S Hill, Muhammed O Afolabi
Background: Heterologous prime-boost vaccination with chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) encoding multiple epitope string thrombospondin-related adhesion protein (ME-TRAP) has shown acceptable safety and promising immunogenicity in African adult and pediatric populations. If licensed, this vaccine could be given to infants receiving routine childhood immunizations. We therefore evaluated responses to ChAd63 MVA ME-TRAP when co-administered with routine Expanded Program on Immunization (EPI) vaccines...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29212182/oncogenic-p95her2-611ctf-primes-human-breast-epithelial-cells-for-metabolic-stress-induced-down-regulation-of-flip-and-activation-of-trail-r-caspase-8-dependent-apoptosis
#19
Rosa Martín-Pérez, Rosario Yerbes, Rocío Mora-Molina, Ana Cano-González, Joaquín Arribas, Massimiliano Mazzone, Abelardo López-Rivas, Carmen Palacios
Oncogenic transformation triggers reprogramming of cell metabolism, as part of the tumorigenic process. However, metabolic reprogramming may also increase the sensitivity of transformed cells to microenvironmental stress, at the early stages of tumor development. Herein, we show that transformation of human breast epithelial cells by the p95HER2/611CTF oncogene markedly sensitizes these cells to metabolic stress induced by the simultaneous inhibition of glucose and glutamine metabolism. In p95HER2/611CTF-transformed cells, metabolic stress activates a TNF related apoptosis-inducing ligand (TRAIL)-R and caspase-8-dependent apoptotic process that requires prior down-regulation of cellular FLICE-like inhibitor protein (c-FLIP) levels...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212039/comprehensive-mapping-of-pluripotent-stem-cell-metabolism-using-dynamic-genome-scale-network-modeling
#20
Sriram Chandrasekaran, Jin Zhang, Zhen Sun, Li Zhang, Christian A Ross, Yu-Chung Huang, John M Asara, Hu Li, George Q Daley, James J Collins
Metabolism is an emerging stem cell hallmark tied to cell fate, pluripotency, and self-renewal, yet systems-level understanding of stem cell metabolism has been limited by the lack of genome-scale network models. Here, we develop a systems approach to integrate time-course metabolomics data with a computational model of metabolism to analyze the metabolic state of naive and primed murine pluripotent stem cells. Using this approach, we find that one-carbon metabolism involving phosphoglycerate dehydrogenase, folate synthesis, and nucleotide synthesis is a key pathway that differs between the two states, resulting in differential sensitivity to anti-folates...
December 5, 2017: Cell Reports
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