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Relational priming

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https://www.readbyqxmd.com/read/28102950/quantitative-impact-of-changes-in-marrow-cellularity-skeletal-size-and-bone-mineral-density-on-active-marrow-dosimetry-based-upon-a-reference-model
#1
Amy M Geyer, Bryan C Schwarz, Robert F Hobbs, George Sgouros, Wesley E Bolch
PURPOSE: The hematopoietically active tissues of skeletal bone marrow are a prime target for computational dosimetry given potential risks of leukemia and, at higher dose levels, acute marrow toxicity. The complex three-dimensional geometry of trabecular spongiosa, however, complicates schema for dose assessment in such a way that only a few reference skeletal models have been developed to date, and which are based upon microimaging of a limited number of cadaveric bone spongiosa cores...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28101702/bone-marrow-very-small-embryonic-like-stem-cells-new-generation-of-autologous-cell-therapy-soon-ready-for-prime-time
#2
EDITORIAL
David M Smadja
Very small embryonic-like stem cells (VSELs) are major pluripotent stem cells described in human and mouse. In this issue of Stem Cell Reviews and Reports, Shaikh and colleagues show in a valuable work that mouse bone marrow collected after 5FU treatment contains VSELs able to undergo in vitro multi-lineage differentiation into cells from all three germ layers and also in germ and hematopoietic cells. These findings are robust since no confounding factor such as feeder cell fusion with VSELs can occur here...
January 18, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28097705/non-polar-lipids-accumulate-during-storage-of-transfusion-products-and-do-not-contribute-to-the-onset-of-transfusion-related-acute-lung-injury
#3
A L Peters, M A T Vervaart, R van Bruggen, D de Korte, R Nieuwland, W Kulik, A P J Vlaar
BACKGROUND AND OBJECTIVES: The accumulation of non-polar lipids arachidonic acid, 5-hydroxyeicosatetraenoic acid (HETE), 12-HETE and 15-HETE during storage of transfusion products may play a role in the onset of transfusion-related acute lung injury (TRALI), a syndrome of respiratory distress after transfusion. MATERIALS AND METHODS: We investigated non-polar lipid accumulation in red blood cells (RBCs) stored for 42 days, plasma stored for 7 days at either 4 or 20°C and platelet (PLT) transfusion products stored for 7 days...
January 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28095740/does-a-single-session-of-reading-literary-fiction-prime-enhanced-mentalising-performance-four-replication-experiments-of-kidd-and-castano-2013
#4
Dalya Samur, Mattie Tops, Sander L Koole
Prior experiments indicated that reading literary fiction improves mentalising performance relative to reading popular fiction, non-fiction, or not reading. However, the experiments had relatively small sample sizes and hence low statistical power. To address this limitation, the present authors conducted four high-powered replication experiments (combined N = 1006) testing the causal impact of reading literary fiction on mentalising. Relative to the original research, the present experiments used the same literary texts in the reading manipulation; the same mentalising task; and the same kind of participant samples...
January 17, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28094450/relational-priming-based-on-a-multiplicative-schema-for-whole-numbers-and-fractions
#5
Melissa DeWolf, Ji Y Son, Miriam Bassok, Keith J Holyoak
Why might it be (at least sometimes) beneficial for adults to process fractions componentially? Recent research has shown that college-educated adults can capitalize on the bipartite structure of the fraction notation, performing more successfully with fractions than with decimals in relational tasks, notably analogical reasoning. This study examined patterns of relational priming for problems with fractions in a task that required arithmetic computations. College students were asked to judge whether or not multiplication equations involving fractions were correct...
January 17, 2017: Cognitive Science
https://www.readbyqxmd.com/read/28093714/neuroplasticity-based-technologies-and-interventions-for-restoring-motor-functions-in-multiple-sclerosis
#6
Sofia Straudi, Nino Basaglia
Motor impairments are very common in multiple sclerosis (MS), leading to a reduced Quality of Life and active participation. In the past decades, new insights into the functional reorganization processes that occur after a brain injury have been introduced. Specifically, the motor practice seems to be determinant to induce neuroplastic changes and motor recovery. More recently, these findings have been extended to multiple sclerosis, in particular, it has been hypothesized that disease progression, functional reorganization and disability are mutually related...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28093629/liquid-release-as-a-source-of-potential-drug-exposure-during-the-handling-of-intravenous-infusions-in-nursing
#7
Verena Segner, Renate Kimbel, Philipp Jochems, André Heinemann, Stephan Letzel, Daniel Wollschläger, Bernd Roßbach
PURPOSE: This study aims at experimentally determining the incidence and extent of liquid releases onto the operator's hands and into the work environment during common nursing operations involving infusions. METHODS: A sequence of operations related to the preparation and administration of infusions was conducted by three subjects for 15 times each using fluorescein marked infusion solutions and two different infusion sets (standard set vs. safety-optimized set)...
January 16, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28089714/effects-of-touch-on-emotional-face-processing-a-study-of-event-related-potentials-facial-emg-and-cardiac-activity
#8
M M Spapé, Harjunen, N Ravaja
Being touched is known to affect emotion, and even a casual touch can elicit positive feelings and affinity. Psychophysiological studies have recently shown that tactile primes affect visual evoked potentials to emotional stimuli, suggesting altered affective stimulus processing. As, however, these studies approached emotion from a purely unidimensional perspective, it remains unclear whether touch biases emotional evaluation or a more general feature such as salience. Here, we investigated how simple tactile primes modulate event related potentials (ERPs), facial EMG and cardiac response to pictures of facial expressions of emotion...
January 12, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28089653/priming-theta-burst-stimulation-enhances-motor-cortex-plasticity-in-young-but-not-old-adults
#9
George M Opie, Eleni Vosnakis, Michael C Ridding, Ulf Ziemann, John G Semmler
BACKGROUND: Primary motor cortex neuroplasticity is reduced in old adults, which may contribute to the motor deficits commonly observed in the elderly. Previous research in young subjects suggests that the neuroplastic response can be enhanced using non-invasive brain stimulation (NIBS), with a larger plastic response observed following priming with both long-term potentiation (LTP) and depression (LTD)-like protocols. However, it is not known if priming stimulation can also modulate plasticity in older adults...
January 4, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28088407/far-off-and-close-up-dry-matter-intake-modulate-indicators-of-immunometabolic-adaptations-to-lactation-in-subcutaneous-adipose-tissue-of-pasture-based-transition-dairy-cows
#10
M Vailati-Riboni, G Farina, F Batistel, A Heiser, M D Mitchell, M A Crookenden, C G Walker, J K Kay, S Meier, J R Roche, J J Loor
The common practice of increasing dietary energy density during the close-up dry period (last ∼3 wk prepartum) has been recently associated with a higher incidence of metabolic disorders after calving. Despite these reports, over-feeding of metabolizable energy (ME) during the far-off, nonlactating period is a common management policy aimed at achieving optimum calving body condition score (BCS) in pasture-based systems, as cows are generally thinner than total mixed ration cows at the end of lactation. Our hypothesis was that both far-off and close-up overfeeding influence the peripartum adipose tissue changes associated with energy balance and inflammatory state...
January 11, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28087924/clinical-testing-of-tuberculosis-vaccine-candidates
#11
Mark Hatherill, Dereck Tait, Helen McShane
It is almost 100 years since the development of bacille Calmette-Guérin (BCG), the only licensed vaccine against tuberculosis (TB). While BCG does confer consistent protection against disseminated disease, there is an urgent need for a more effective vaccine against pulmonary disease. There are several indications for such an improved vaccine, including prevention of infection, prevention of disease, and a therapeutic vaccine to prevent recurrent disease. The two main approaches to TB vaccine development are developing an improved whole mycobacterial priming agent to replace BCG and/or developing a subunit booster vaccine to be administered after a BCG or BCG replacement priming vaccination...
October 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28086956/differential-expression-of-e-type-prostanoid-receptors-2-and-4-in-microglia-stimulated-with-lipopolysaccharide
#12
Ester Bonfill-Teixidor, Amaia Otxoa-de-Amezaga, Miriam Font-Nieves, M Glòria Sans-Fons, Anna M Planas
BACKGROUND: Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE2) is one of the products of COX activity. PGE2 has pleiotropic actions depending on the activation of specific E-type prostanoid EP1-4 receptors. We investigated the involvement of PGE2 and EP receptors in glial activation in response to an inflammatory challenge induced by LPS. METHODS: Cultures of mouse microglia or astroglia cells were treated with LPS in the presence or absence of COX-2 inhibitors, and the production of PGE2 was measured by ELISA...
January 5, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28086788/comprehensive-circrna-expression-profile-and-selection-of-key-circrnas-during-priming-phase-of-rat-liver-regeneration
#13
Lifei Li, Jianlin Guo, Yanhui Chen, Cuifang Chang, Cunshuan Xu
BACKGROUND: Rat liver regeneration (LR) proceeds along a process of highly organized and ordered tissue growth in response to the loss or injury of liver tissue, during which many physiological processes may play important roles. The molecular mechanism of hepatocyte proliferation, energy metabolism and substance metabolism during rat LR had been elucidated. Further, the correlation of circular RNA (circRNA) abundance with proliferation has recently been clarified. However, the regulatory capacity of circRNA in rat LR remains a fascinating topic...
January 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28081174/definition-of-human-epitopes-recognized-in-tetanus-toxoid-and-development-of-an-assay-strategy-to-detect-ex-vivo-tetanus-cd4-t-cell-responses
#14
Ricardo da Silva Antunes, Sinu Paul, John Sidney, Daniela Weiskopf, Jennifer M Dan, Elizabeth Phillips, Simon Mallal, Shane Crotty, Alessandro Sette, Cecilia S Lindestam Arlehamn
Despite widespread uses of tetanus toxoid (TT) as a vaccine, model antigen and protein carrier, TT epitopes have been poorly characterized. Herein we defined the human CD4+ T cell epitope repertoire by reevaluation of previously described epitopes and evaluation of those derived from prediction of HLA Class II binding. Forty-seven epitopes were identified following in vitro TT stimulation, with 28 epitopes accounting for 90% of the total response. Despite this diverse range of epitopes, individual responses were associated with only a few immunodominant epitopes, with each donor responding on average to 3 epitopes...
2017: PloS One
https://www.readbyqxmd.com/read/28078556/response-readiness-modulates-the-development-of-association-based-automaticity-in-masked-priming
#15
Yongchun Wang, Yonghui Wang, Peng Liu, Meilin Di, Yanyan Gong, Li Zhao, Qi Chen
The current study investigated the role of the automatization of stimulus and response (S-R) associations and response readiness in triggering the motor activation for masked primes in two experiments. The automatization of associations was manipulated by employing different types of stimuli, and response readiness was manipulated by varying the relative frequency of Go trials in a modified Go/No-Go task. Compatibility (compatible and incompatible), stimulus type (arrows and parallel lines), and test session (Sessions 1, 2, and 3) were manipulated in a high response-readiness condition (Experiment 1) and in a low response-readiness condition (Experiment 2)...
January 11, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28073931/histones-and-neutrophil-extracellular-traps-enhance-tubular-necrosis-and-remote-organ-injury-in-ischemic-aki
#16
Daigo Nakazawa, Santhosh V Kumar, Julian Marschner, Jyaysi Desai, Alexander Holderied, Lukas Rath, Franziska Kraft, Yutian Lei, Yuichiro Fukasawa, Gilbert W Moeckel, Maria Lucia Angelotti, Helen Liapis, Hans-Joachim Anders
Severe AKI is often associated with multiorgan dysfunction, but the mechanisms of this remote tissue injury are unknown. We hypothesized that renal necroinflammation releases cytotoxic molecules that may cause remote organ damage. In hypoxia-induced tubular epithelial cell necrosis in vitro, histone secretion from ischemic tubular cells primed neutrophils to form neutrophil extracellular traps. These traps induced tubular epithelial cell death and stimulated neutrophil extracellular trap formation in fresh neutrophils...
January 10, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28071648/foliar-application-of-the-leaf-colonizing-yeast-pseudozyma-churashimaensis-elicits-systemic-defense-of-pepper-against-bacterial-and-viral-pathogens
#17
Gahyung Lee, Sang-Heon Lee, Kyung Mo Kim, Choong-Min Ryu
Yeast associates with many plant parts including the phyllosphere, where it is subject to harsh environmental conditions. Few studies have reported on biological control of foliar pathogens by yeast. Here, we newly isolated leaf-colonizing yeasts from leaves of field-grown pepper plants in a major pepper production area of South Korea. The yeast was isolated using semi-selective medium supplemented with rifampicin to inhibit bacterial growth and its disease control capacity against Xanthomonas axonopodis infection of pepper plants in the greenhouse was evaluated...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069052/toward-a-comprehensive-drug-ontology-extraction-of-drug-indication-relations-from-diverse-information-sources
#18
Mark E Sharp
BACKGROUND: Drug ontologies could help pharmaceutical researchers overcome information overload and speed the pace of drug discovery, thus benefiting the industry and patients alike. Drug-disease relations, specifically drug-indication relations, are a prime candidate for representation in ontologies. There is a wealth of available drug-indication information, but structuring and integrating it is challenging. RESULTS: We created a drug-indication database (DID) of data from 12 openly available, commercially available, and proprietary information sources, integrated by terminological normalization to UMLS and other authorities...
January 10, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28068961/contradictory-individualized-self-blaming-a-cross-sectional-study-of-associations-between-expectations-to-managers-coworkers-one-self-and-risk-factors-for-musculoskeletal-disorders-among-construction-workers
#19
Jeppe Zielinski Nguyen Ajslev, Roger Persson, Lars Louis Andersen
BACKGROUND: Within work sociology, several studies have addressed construction workers' practices of masculinity, class, economy, safety risks and production. However, few studies have investigated room for agency in relation to bodily pain or musculoskeletal disorders and even fewer have made a quantitative approach. Accordingly, by means of a questionnaire, we examined the association between construction workers' room for agency and physical exertion, bodily and mental fatigue, and lower back pain...
January 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28068576/invisible-own-and-other-race-faces-presented-under-continuous-flash-suppression-produce-affective-response-biases
#20
Jie Yuan, Xiaoqing Hu, Yuhao Lu, Galen V Bodenhausen, Shimin Fu
One triumph of the human mind is the ability to place the multitudinous array of people we encounter into in- and out-group members based on racial characteristics. One fundamental question that remains to be answered is whether invisible own- and other-race faces can nevertheless influence subsequent affective judgments. Here, we employed continuous flash suppression (CFS) to render own- and other-race faces unperceivable in an affective priming task. Both on-line and off-line awareness checks were employed to provide more stringent control of partial awareness...
January 6, 2017: Consciousness and Cognition
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