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https://www.readbyqxmd.com/read/29690576/nuc041-a-prodrug-of-the-dna-methytransferase-inhibitor-5-aza-2-2-difluorodeoxycytidine-nuc013-leads-to-tumor-regression-in-a-model-of-non-small-cell-lung-cancer
#1
Richard Daifuku, Sheila Grimes, Murray Stackhouse
5-aza-2′,2′-difluorodeoxycytidine (NUC013) has been shown to be significantly safer and more effective than decitabine in xenograft models of human leukemia and colon cancer. However, it suffers from a similar short half-life as other DNA methyltransferase inhibitors with a 5-azacytosine base, which is problematic for nucleosides that primarily target tumor cells in S phase. Because of the relative instability of 5-azanucleosides, a prodrug approach was developed to improve the pharmacology of NUC013...
April 23, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29690543/memory-function-in-feeding-habit-transformation-of-mandarin-fish-siniperca-chuatsi
#2
Yaqi Dou, Shan He, Xu-Fang Liang, Wenjing Cai, Jie Wang, Linjie Shi, Jiao Li
Mandarin fish refuse dead prey fish or artificial diets and can be trained to transform their inborn feeding habit. To investigate the effect of memory on feeding habit transformation, we compared the reaction time to dead prey fish and the success rate of feeding habit transformation to dead prey fish with training of mandarin fish in the 1st experimental group (trained once) and the 2nd experimental group (trained twice). The mandarin fish in the 2nd group had higher success rate of feeding habit transformation (100%) than those in the 1st group (67%), and shorter reaction time to dead prey fish (<1 s) than those in the 1st group (>1 s)...
April 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29690516/evaluation-of-manganese-chloride-s-effect-on-biosynthetic-properties-of-in-vitro-cultures-of-eschscholzia-californica-cham
#3
Andrea Balažová, Júlia Urdová, František Bilka, Ivana Holková, Branislav Horváth, Vladimír Forman, Pavel Mučaji
The basal production of secondary metabolites in medicinal plants is limited. One of the effective approaches that encourages plants to produce a remarkable amount of precious compounds is an application of elicitors. Our work was focused on the elicitation of Eschscholzia californica Cham. suspension cultures using various concentrations of MnCl₂ (5; 10; 15 mg/L) with the aim of evaluating its effect on sanguinarine, chelerythrine, and macarpine production and gene expression of enzymes involved in the biosynthesis of mentioned secondary metabolites (BBE, 4&prime;-OMT, CYP80B1) or in defense processes (LOX)...
April 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29689332/characterization-and-overexpression-of-rho1-from-cryptococcus-laurentii-zju10-activates-cwi-signaling-pathway-on-enhancing-the-inhibition-of-blue-mold-on-pears
#4
Ming Lin, Yangyang Zhang, Cui Sun, Yining Huang, Jiahui Zhang, Xiaodong Zheng, Ting Yu
Results from this study explored the inhibitory effect of RHO1 gene (GenBank accession number KY859864) from the antagonistic yeast, Cryptococcus laurentii ZJU10, on the control of Penicillium expansum in pear fruit and its possible mechanism involved. The RHO1 gene was successfully cloned and overexpressed in Saccharomyces cerevisiae. Sequence analysis showed high similarity with Rho family proteins, implying a primary role of Rho1 in the cell wall integrity (CWI) signaling pathway. Gene expression of RHO1 and other five CWI-related genes (including Pkc1, Rlm1, Fks1, Fks2 and Chs3) were significant up-regulated in the treatment of SC/Rho1-induced strain (Saccharomyces cerevisiae transformed with RHO1 and induced by galactose)...
April 19, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29689120/acute-on-chronic-liver-failure-getting-ready-for-prime-time
#5
Jasmohan S Bajaj, Richard Moreau, Patrick S Kamath, Hugo E Vargas, Vicente Arroyo, K Rajender Reddy, Gyongyi Szabo, Puneeta Tandon, Jody Olson, Constantine Karvellas, Thierry Gustot, Jennifer C Lai, Florence Wong
Acute on chronic liver failure (ACLF) is a culmination of chronic liver disease and extra-hepatic organ failures, which is associated with a high short-term mortality and immense healthcare expenditure. There are varying definitions for organ failures and ACLF in Europe, North America and Asia. These differing definitions need to be reconciled to enhance progress in the field. The pathogenesis of ACLF is multi-factorial and related to interactions between the immuno-inflammatory system, microbiota and the precipitating factors...
April 24, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29687552/gut-microbial-functional-maturation-and-succession-during-human-early-life
#6
Tomás Cerdó, Alicia Ruiz, Inmaculada Acuña, Ruy Jáuregui, Nico Jehmlich, Sven-Bastian Haange, Martin von Bergen, Antonio Suárez, Cristina Campoy
The evolutional trajectory of gut microbial colonization from birth has been shown to prime for health later in life. Here, we combined cultivation-independent 16S rRNA gene sequencing and metaproteomics to investigate the functional maturation of gut microbiota in faecal samples from full-term healthy infants collected at 6 and 18 months of age. Phylogenetic analysis of the metaproteomes showed that Bifidobacterium provided the highest number of distinct protein groups. Considerable divergences between taxa abundance and protein phylogeny were observed at all taxonomic ranks...
April 24, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29687190/monitoring-healthy-and-disturbed-sleep-through-smartphone-applications-a-review-of-experimental-evidence
#7
REVIEW
Edita Fino, Michela Mazzetti
Smartphone applications are considered as the prime candidate for the purposes of large-scale, low-cost and long-term sleep monitoring. How reliable and scientifically grounded is smartphone-based assessment of healthy and disturbed sleep remains a key issue in this direction. Here we offer a review of validation studies of sleep applications to the aim of providing some guidance in terms of their reliability to assess sleep in healthy and clinical populations, and stimulating further examination of their potential for clinical use and improved sleep hygiene...
April 23, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29685796/fluids-and-organ-dysfunction-a-narrative-review-of-the-literature-and-discussion-of-5-controversial-topics
#8
Adam J Kingeter, Meredith A Kingeter, Andrew D Shaw
Evidence-based clinical decision making is at the forefront of modern cardiothoracic anesthesia practice. Therefore, as a field, cardiac anesthesiologist should strive to ensure that the available evidence is of the highest possible quality. In this narrative review, 5 important topics that the authors believe require additional investigation in cardiothoracic anesthesia and critical care related to fluid therapy and organ dysfunction are outlined briefly. In particular, the authors believe that the areas of pulmonary artery catheter use, restrictive versus liberal transfusion strategies, cardiopulmonary bypass prime composition, colloid use in resuscitation and its effects on acute kidney injury, and management of acute kidney injury after cardiac surgery hold many unanswered questions and opportunities for continued improvement in the specialty of cardiac anesthesia...
March 13, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29681945/white-matter-damage-in-4-725-term-born-infants-is-determined-by-head-circumference-at-birth-the-missing-link
#9
Arne Jensen, Bert Holmer
Background: White matter damage (WMD) is a prime risk factor for cerebral palsy, in part occurring unexplained. Though primarily a problem of preterm infants, there is growing evidence that in large newborns cephalopelvic disproportion and prolonged labor are involved. Objective: To explore both incidence of and morphometric risk factors for WMD in term-born infants. Study Design: We related growth variables and risk factors of term-born infants to WMD (61/4,725) using odds ratios of z -score bands...
2018: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/29680922/bioindicator-responses-and-performance-of-plant-species-along-a-vehicular-pollution-gradient-in-western-himalaya
#10
Rachit Kashyap, Rohit Sharma, Sanjay Kr Uniyal
Loss of green cover, and increasing pollution is a prime global concern. The problem calls for screening of pollution-tolerant tree species that can be integrated into plantation drives. Recognizing this, the study analyzed bio-indicator responses and performance of commonly occurring plant species along a pollution gradient in western Himalaya. Based on distance from the road, three sites viz., highly polluted (HP), moderately polluted (MP), and least polluted (LP), were identified. From these sites, leaves of commonly occurring 26 tree species were collected and analyzed for dust accumulation, total chlorophyll, relative water content (RWC), ascorbic acid, and pH using standard protocols...
April 21, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29679885/the-influence-of-religious-concepts-on-the-effects-of-blame-appraisals-on-negative-emotions
#11
Eddie M W Tong, Alan Q H Teo
This research examined the regulatory effects of religious concepts on appraisal-emotion processes, focusing on concepts related to God and the relationships between blame appraisals and anger and guilt. In two experimental studies (Studies 1 and 2), blame appraisals were manipulated while participants were exposed to a God or neutral prime, in the context of a failed laboratory task. In an event-sampling study (Study 3), daily blame appraisals and emotions were measured repeatedly in naturalistic environments and their relationships under high perceived moral unacceptability were examined in relation to participants' the tendency to focus on God (God-focus)...
April 18, 2018: Cognition
https://www.readbyqxmd.com/read/29677537/the-rescue-effect-of-mesenchymal-stem-cell-on-sodium-iodate-induced-retinal-pigment-epithelial-cell-death-through-deactivation-of-nf-%C3%AE%C2%BAb-mediated-nlrp3-inflammasome
#12
Xiying Mao, Ting Pan, Han Shen, Huiyu Xi, Songtao Yuan, Qinghuai Liu
Age-related macular degeneration (AMD) is a multifactorial disease resulting in the gradual loss of retinal pigment epithelium (RPE) and the permanent visual damage. Various risk factors, including oxidative stress, form a complex network at the confluence of inflammation. Mesenchymal stem cell (MSC) is a well-studied population of adult stem cell with strong neuroprotective and immunoregulatory properties. Here, we reported the protective effect of MSC on sodium iodate (NaIO3)-triggered RPE degeneration. Sodium iodate (NaIO3)-induced RPE cell death was remarkably reduced when cocultured with MSC...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29676975/eighteen-month-clinical-study-of-universal-adhesives-in-noncarious-cervical-lesions
#13
V C Ruschel, S Shibata, S C Stolf, Y Chung, L N Baratieri, H O Heymann, R Walter
OBJECTIVE: To evaluate the clinical performance of Scotchbond Universal (3M Oral Care) and Prime & Bond Elect (Dentsply Sirona) in the restoration of noncarious cervical lesions (NCCLs). METHODS AND MATERIALS: This was a randomized controlled clinical trial involving 63 subjects. Two hundred and three NCCLs were restored using Scotchbond Universal and Prime & Bond Elect using both an etch-and-rinse and a self-etch technique. Lesions were notch-shaped NCCLs, and the restorations were placed without any mechanical retention...
May 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29676596/lung-dendritic-cells-drive-nk-cytotoxicity-in-chronic-obstructive-pulmonary-disease-via-il-15r%C3%AE
#14
Donna K Finch, Valerie R Stolberg, John Ferguson, Henrih Alikaj, Mohamed R Kady, Bradley W Richmond, Vasiliy V Polosukhin, Timothy S Blackwell, Lisa McCloskey, Jeffrey L Curtis, Christine M Freeman
RATIONALE: Lung natural killer (NK) cells kill a greater percentage of autologous lung parenchymal cells in COPD than in non-obstructed smokers. To become cytotoxic, NKs require priming, typically by dendritic cells (DC), but whether priming occurs in the lungs in COPD is unknown. METHODS: We used lung tissue and in some cases peripheral blood from patients undergoing clinically-indicated resections to determine in vitro killing of CD326+ lung epithelial cells by isolated lung CD56+ NKs...
April 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29673163/probing-the-inhibitor-versus-chaperone-properties-of-sp%C3%A2-iminosugars-towards-human-%C3%AE-glucocerebrosidase-a-picomolar-chaperone-for-gaucher-disease
#15
Teresa Mena-Barragán, M Isabel García-Moreno, Alen Sevšek, Tetsuya Okazaki, Eiji Nanba, Katsumi Higaki, Nathaniel I Martin, Roland J Pieters, José M García Fernández, Carmen Ortiz Mellet
A series of sp²-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern (d- gluco or l- ido ), the architecture of the glycone skeleton, and the nature of the nonglycone substituent has been synthesized and assayed for their inhibition properties towards commercial glycosidases. On the basis of their affinity and selectivity towards GH1 &beta;-glucosidases, reducing and nonreducing bicyclic derivatives having a hydroxylation profile of structural complementarity with d-glucose and incorporating an N&prime; -octyl-isourea or -isothiourea segment were selected for further evaluation of their inhibitory/chaperoning potential against human glucocerebrosidase (GCase)...
April 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29669746/learning-dependent-and-independent-enhancement-of-mitral-tufted-cell-glomerular-odor-responses-following-olfactory-fear-conditioning-in-awake-mice
#16
Jordan M Ross, Max L Fletcher
Associative fear learning produces fear toward the conditioned stimulus (CS) and often generalization, the expansion of fear from the CS to similar, unlearned stimuli. However, how fear learning affects early sensory processing of learned and unlearned stimuli in relation to behavioral fear responses to these stimuli remains unclear. We subjected male and female mice expressing the fluorescent calcium indicator GCaMP3 in olfactory bulb mitral and tufted cells to a classical olfactory fear conditioning paradigm...
April 18, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29669531/assessment-of-an-optimized-manufacturing-process-for-inactivated-quadrivalent-influenza-vaccine-a-phase-iii-randomized-double-blind-safety-and-immunogenicity-study-in-children-and-adults
#17
Carine Claeys, Mamadou Drame, José García-Sicilia, Khalequ Zaman, Alfonso Carmona, Phu My Tran, Mariano Miranda, Federico Martinón-Torres, Franck Thollot, Michael Horn, Tino F Schwarz, Ulrich Behre, José M Merino, Iwona Sadowska-Krawczenko, Henryk Szymański, Peter Schu, Elisabeth Neumeier, Ping Li, Varsha K Jain, Bruce L Innis
BACKGROUND: GSK has modified the licensed monovalent bulk manufacturing process for its split-virion inactivated quadrivalent influenza vaccine (IIV4) to harmonize the process among different strains, resulting in an increased number of finished vaccine doses, while compensating for the change from inactivated trivalent influenza vaccine (IIV3) to IIV4. To confirm the manufacturing changes do not alter the profile of the vaccine, a clinical trial was conducted to compare IIV4 made by the currently licensed process with a vaccine made by the new (investigational) process (IIV4-I)...
April 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29668394/it-s-the-other-way-around-early-modulation-of-sensory-distractor-processing-induced-by-late-response-conflict
#18
Bernhard Pastötter, Christian Frings
Understanding the neural processes that maintain goal-directed behavior is a major challenge for the study of attentional control. Although much of the previous work on the issue has focused on prefrontal brain areas, little is known about the contribution of sensory brain processes to the regulation of attentional control. The present EEG study examined brain oscillatory activities invoked in the processing of response conflict in a lateralized Eriksen single-flanker task, in which target letters were presented at fixation and single distractor letters were presented either left or right to the targets...
April 18, 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29665438/enhancement-of-anti-tubercular-activity-and-biomass-of-fermented-food-associated-staphylococcus-hominis-strain-manf2-using-taguchi-orthogonal-array-and-box-behnken-design
#19
Ameer Khusro, Chirom Aarti, Azger Dusthackeer, Paul Agastian
The prime focus of the present investigation was to optimize statistically the anti-tubercular activity and biomass of fermented food associated Staphylococcus hominis strain MANF2 using Taguchi orthogonal array (OA) and Box-Behnken design (BBD). The anti-tubercular activity of strain MANF2 was determined against Mycobacterium tuberculosis H37Rv using luciferase reporter phase assay. Among varied media examined, the isolate exhibited impressive anti-tubercular activity with paramount relative light unit reduction of >90% in de Man Rogose Sharpe (MRS) broth...
April 14, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29665351/neuroendocrine-response-to-gaba-b-receptor-agonism-in-alcohol-dependent-individuals-results-from-a-combined-outpatient-and-human-laboratory-experiment
#20
Mehdi Farokhnia, Mikela B Sheskier, Mary R Lee, April N Le, Erick Singley, Sofia Bouhlal, Timmy Ton, Zhen Zhao, Lorenzo Leggio
Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the nervous system, plays an important role in biobehavioral processes that regulate alcohol seeking, food intake, and stress response. The metabotropic GABA-B receptor has been investigated as a potential therapeutic target for alcohol use disorder, by using orthosteric agonists (e.g., baclofen) and positive allosteric modulators. Whether and how pharmacological manipulation of the GABA-B receptor, in combination with alcohol intake, may affect feeding- and stress-related neuroendocrine pathways remains unknown...
April 14, 2018: Neuropharmacology
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