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https://www.readbyqxmd.com/read/28434756/evaluation-of-tinnitus-retraining-therapy-for-patients-with-normal-audiograms-versus-patients-with-hearing-loss
#1
Kana Lee, Kunihiko Makino, Kohei Yamahara
OBJECTIVE: A few chronic tinnitus patients show normal hearing thresholds in the pure tone audiometry from 125Hz to 8000Hz (≤20dB). We report the characteristics of the course of those patients underwent tinnitus retraining therapy (TRT) compared with other patients suffering from chronic and severe tinnitus. METHODS: We identified 13 patients with normal hearing thresholds among 242 patients suffering over 3 months, Tinnitus Handicap Inventory (THI) ≥16/100, and follow up period is over 6 months...
April 20, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28422383/liquid-and-subcritical-fluid-chromatographic-enantioseparation-of-n-%C3%AE-fmoc-proteinogenic-amino-acids-on-quinidine-based-zwitterionic-and-anion-exchanger-type-chiral-stationary-phases-a-comparative-study
#2
Gyula Lajkó, Nóra Grecsó, Gábor Tóth, Ferenc Fülöp, Wolfgang Lindner, István Ilisz, Antal Péter
Stereoselective high-performance liquid chromatographic and subcritical fluid chromatographic separations of 19 N(α) -Fmoc proteinogenic amino acid enantiomers were carried out by using Quinidine-based zwitterionic and anion-exchanger-type chiral stationary phases Chiralpak ZWIX(-) and QD-AX. For optimization of retention and enantioselectivity, the ratio of bulk solvent components (MeOH/MeCN, H2 O/MeOH, or CO2 /MeOH) and the nature and concentration of the acid and base additives (counter- and co-ions) were systematically varied...
April 19, 2017: Chirality
https://www.readbyqxmd.com/read/28418420/selective-purification-and-chemical-labeling-of-a-target-protein-on-ruthenium-photocatalyst-functionalized-affinity-beads
#3
Michihiko Tsushima, Shinichi Sato, Hiroyuki Nakamura
Selective purification and chemical labeling of a target protein in a protein mixture were simultaneously achieved on the surface of affinity beads functionalized with ligands, such as benzenesulfonamide and methotrexate (MTX), and a ruthenium complex containing 2,2'-bipyridine-4,4'-dicarboxylic acid (dcbpy). Chemical labeling of the target protein with a tyrosine radical trapper (TRT) proceeded on the surface of the beads when the target protein was in close proximity to the ruthenium photocatalyst. Both the protein purification and chemical labeling abilities of the affinity beads functionalized with ruthenium photocatalyst were not compromised after recycling several times...
April 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28410143/targeted-radionuclide-therapy-frontiers-in-theranostics
#4
Francesca Gallivanone, Mauro Valente, Annarita Savi, Carla Canevari, Isabella Castiglioni
The concept of targeted radionuclide therapy (TRT) relies on the use of injected nuclear medicine as treating agents, targeted at the cellular or molecular level. The growth of the interest in TRT was stimulated by the advances in radionuclide production and labeling as well as by the improvement in the knowledge of appropriate and specific molecular targets. In recent years, different studies on TRT were focused on the evaluation of radionuclide compounds able to combine imaging of the disease with TRT, in a theranostic approach...
June 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28394396/effects-of-immunomodulatory-nutrients-on-growth-performance-and-immune-related-gene-expression-in-layer-chicks-challenged-with-lipopolysaccharide
#5
E L Wils-Plotz, K C Klasing
Immunomodulatory nutrients alter the immune response to pathogens. This study was conducted to determine the effects of immunomodulatory nutrients on the immune response to a lipopolysaccharide (LPS) challenge of layer chicks fed supplemental corn oil (control; 3%), fish oil (3%), conjugated linoleic acid (CLA; 1%), lutein (0.05 g/kg), or vitamin E (90 I.U./ kg). Four-week-old layer chicks were allotted to 10 treatment groups arranged as a 2 × 5 factorial with 2 sexes and 5 dietary treatments (TRT; 5 replicate pens of 2 male and 2 female chicks per TRT)...
March 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28388868/equivalence-and-test-retest-reproducibility-of-conventional-and-extended-high-frequency-audiometric-thresholds-obtained-using-pure-tone-and-narrow-band-noise-stimuli
#6
Andrew B John, Brian M Kreisman
OBJECTIVES: Extended high-frequency (EHF) audiometry is useful for evaluating ototoxic exposures and may relate to speech recognition, localisation and hearing aid benefit. There is a need to determine whether common clinical practice for EHF audiometry using tone and noise stimuli is reliable. We evaluated equivalence and compared test-retest (TRT) reproducibility for audiometric thresholds obtained using pure tones and narrowband noise (NBN) from 0.25 to 16 kHz. DESIGN: Thresholds and test-retest reproducibility for stimuli in the conventional (0...
April 7, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28382303/evaluation-of-the-efficacy-of-cisplatin-etoposide-and-the-role-of-thoracic-radiotherapy-and-prophylactic-cranial-irradiation-in-lcnec
#7
Arsela Prelaj, Sara Elena Rebuzzi, Gabriella Del Bene, Julio Rodrigo Giròn Berrìos, Alessandra Emiliani, Lucilla De Filippis, Alessandra Anna Prete, Silvia Pecorari, Gaia Manna, Carla Ferrara, Daniele Rossini, Flavia Longo
In small-cell lung cancer (SCLC), the role of chemotherapy and radiotherapy is well established. Large-cell neuroendocrine carcinoma (LCNEC) shares several clinicopathological features with SCLC, but its optimal therapy is not defined. We evaluated clinical response and survival outcomes of advanced LCNEC treated in first-line therapy compared with SCLC. 72 patients with stage III-IV LCNEC (n=28) and extensive-stage SCLC (ES-SCLC) (n=44) received cisplatin-etoposide with/without thoracic radiotherapy (TRT) and prophylactic cranial irradiation (PCI)...
January 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28377392/effects-of-testosterone-and-evoked-resistance-exercise-after-spinal-cord-injury-terex-sci-study-protocol-for-a-randomised-controlled-trial
#8
Ashraf S Gorgey, Refka E Khalil, Ranjodh Gill, Laura C O'Brien, Timothy Lavis, Teodoro Castillo, David X Cifu, Jeannie Savas, Rehan Khan, Christopher Cardozo, Edward J Lesnefsky, David R Gater, Robert A Adler
INTRODUCTION: Individuals with spinal cord injury (SCI) are at a lifelong risk of obesity and chronic metabolic disorders including insulin resistance and dyslipidemia. Within a few weeks of injury, there is a significant decline in whole body fat-free mass, particularly lower extremity skeletal muscle mass, and subsequent increase in fat mass (FM). This is accompanied by a decrease in anabolic hormones including testosterone. Testosterone replacement therapy (TRT) has been shown to increase skeletal muscle mass and improve metabolic profile...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28361372/state-of-the-art-a-review-of-cardiovascular-effects-of-testosterone-replacement-therapy-in-adult-males
#9
REVIEW
Ahmed Elsherbiny, Matthew Tricomi, Digant Bhatt, Hari Kumar Dandapantula
PURPOSE OF REVIEW: According to an Endocrine Society Clinical Practice Guideline published in June 2010, testosterone replacement therapy (TRT) should be administered only to men who are hypogonadal with documented low testosterone level on two morning measurements. This recommendation was based on previous studies that did not show an increased risk in cardiovascular events with TRT. In contrast, recent studies did show an increased risk which prompted the FDA to investigate further...
April 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28358911/assessment-of-the-retinal-posterior-pole-in-dominant-optic-atrophy-by-spectral-domain-optical-coherence-tomography-and-microperimetry
#10
Massimo Cesareo, Elena Ciuffoletti, Alessio Martucci, Jacopo Sebastiani, Roberto Pietro Sorge, Eleonora Lamantea, Barbara Garavaglia, Federico Ricci, Andrea Cusumano, Carlo Nucci, Francesco Brancati
BACKGROUND: To assess posterior pole (PP) retinal structure in patients with genetically confirmed autosomal dominant optic atrophy (ADOA) using new spectral domain optical coherence tomography (SD-OCT) segmentation technology. To analyze retinal PP thickness in relation to retinal sensitivity data from microperimetry (MP) in ADOA patients. METHODS AND FINDINGS: This prospective cross-sectional study included 11 patients with ADOA and 11 age-matched healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28349138/metal-coordination-of-ferrocene-histidine-conjugates
#11
Annaleizle Ferranco, Shibaji Basak, Alan Lough, Heinz-Bernhard Kraatz
This study presents a few bis(histidine) ligands working to build a small peptidic model system of zinc structural sites. Ferrocene-peptide conjugates Fc[CO-His(Trt)-His(Trt)-OMe]2 (3), Fc[CO-His(Trt)-Asp(OMe)-OMe]2 (4), and Fc[CO-His(Trt)-Glu(OMe)-OMe]2 (5) were synthesized and characterized spectroscopically. (1)H-NMR and IR spectroscopic studies reveal hydrogen bonding interactions and while more detailed circular dichroism studies show a 1,2'-P helical "Herrick conformation" for Fc-conjugates 4 and 5, we discovered M-helical chirality in Fc-peptide 3...
March 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28347184/effects-of-testosterone-replacement-therapy-on-hypogonadal-men-with-osteopenia-or-osteoporosis-a-subanalysis-of-a-prospective-randomized-controlled-study-in-japan-earth-study
#12
Kazuyoshi Shigehara, Hiroyuki Konaka, Eitetsu Koh, Kazufumi Nakashima, Masashi Iijima, Takahiro Nohara, Koji Izumi, Yasuhide Kitagawa, Yoshifumi Kadono, Kazuhiro Sugimoto, Teruaki Iwamoto, Atsushi Mizokami, Mikio Namiki
OBJECTIVE: We investigated the effects of testosterone replacement therapy (TRT) on bone mineral density (BMD) among hypogonadal men with osteopenia/osteoporosis. METHODS: From our previous EARTH study population, 74 patients with a clinical diagnosis of osteopenia or osteoporosis and hypogonadism were included in this study, as the TRT (n = 35) and control (n = 34) groups. The TRT group was administered 250 mg of testosterone enanthate injection every 4 weeks for 12 months...
March 28, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28346975/hypothyroidism-is-associated-with-all-cause-mortality-in-a-national-cohort-of-chronic-hemodialysis-patients
#13
Hsuan-Jen Lin, Chung-Chih Lin, Hsuan Ming Lin, Hsuan-Ju Chen, Che-Chen Lin, Chiz-Tzung Chang, Che-Yi Chou, Chiu-Ching Huang
BACKGROUND: The prevalence of hypothyroidism is high in hemodialysis (HD) patients and hypothyroidism increases all-cause mortality in HD patients. Comorbidities are common in HD patients and are associated with both mortality and hypothyroidism. The aim of the study is to explore the effect of the interactions of comorbidities and hypothyroidism on all-cause mortality in HD patients. METHOD: Patients with hypothyroidism (ICD-9-CM 244.0, 244.1, and 244.9) and matched patients without hypothyroidism in the Registry for Catastrophic Illness Patient Database of Taiwan Health Insurance from 2000 to 2010 were analyzed...
March 27, 2017: Nephrology
https://www.readbyqxmd.com/read/28344753/statin-testosterone-and-phosphodiesterase-5-inhibitor-treatments-and-age-related-mortality-in-diabetes
#14
Geoffrey Hackett, Peter W Jones, Richard C Strange, Sudarshan Ramachandran
AIM: To determine how statins, testosterone (T) replacement therapy (TRT) and phosphodiesterase 5-inhibitors (PDE5I) influence age related mortality in diabetic men. METHODS: We studied 857 diabetic men screened for the BLAST study, stratifying them (mean follow-up = 3.8 years) into: (1) Normal T levels/untreated (total T > 12 nmol/L and free T > 0.25 nmol/L), Low T/untreated and Low T/treated; (2) PDE5I/untreated and PDE5I/treated; and (3) statin/untreated and statin/treated groups...
March 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28340925/duration-of-twice-daily-thoracic-radiotherapy-and-time-from-the-start-of-any-treatment-to-the-end-of-chest-irradiation-as-significant-predictors-of-outcomes-in-limited-disease-small-cell-lung-cancer
#15
Masahiro Morimoto, Kyoichi Okishio, Masanori Akira, Naoki Omachi, Akihiro Tamiya, Kazuhiro Asami, Tomoya Kawaguchi, Shinji Atagi
BACKGROUND: The hypothesis of this retrospective study was that the duration of twice-daily (BID) thoracic radiotherapy (TRT) and time from the start of any treatment to the end of chest irradiation (SER) would predict outcomes in limited-disease small-cell lung cancer. MATERIALS AND METHODS: All 81 patients received 45 Gy in 30 fractions BID with a ≥ 6-hour interval and concurrent chemotherapy of platinum and etoposide. RESULTS: The median radiotherapy duration was 25 days (range, 21-38 days)...
March 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28339404/the-influence-of-task-related-training-combined-with-transcutaneous-electrical-nerve-stimulation-on-paretic-upper-limb-muscle-activation-in-patients-with-chronic-stroke
#16
Kyoungsim Jung, Jinhwa Jung, Taesung In, Taehoon Kim, Hwi-Young Cho
OBJECTIVES: This study investigated the efficacy of Task-Related Training (TRT) Combined with Transcutaneous Electrical Nerve Stimulation (TENS) on the improvement of upper limb muscle activation in chronic stroke survivors with mild or moderate paresis. METHODS: A single-blind, randomized clinical trial was conducted with 46stroke survivors with chronic paresis. They were randomly allocated two groups: the TRT+TENS group (n = 23) and the TRT+ placebo TENS (TRT+PLBO) group (n = 23)...
March 23, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28333214/-forever-young-%C3%A2-testosterone-replacement-therapy-a-blockbuster-drug-despite-flabby-evidence-and-broken-promises
#17
Andrea Busnelli, Edgardo Somigliana, Paolo Vercellini
In the last decade, testosterone replacement therapy (TRT) has been increasingly prescribed to treat a controversial condition known as 'late-onset hypogonadism (LOH)'. This syndrome is diagnosed in men who, for no discernible reason other than older age, obesity or ill health have serum testosterone concentrations below the normal range for healthy young men and report one or more of the following symptoms: muscle weakness or wasting, mood, behaviour and cognition-related symptoms and sexual function or libido impairment...
April 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28326834/thoracic-radiation-therapy-could-give-survival-benefit-to-elderly-patients-with-extensive-stage-small-cell-lung-cancer
#18
Changchun An, Wang Jing, Yan Zhang, Sujing Liu, Haiyong Wang, Kunli Zhu, Li Kong, Hongbo Guo, Hui Zhu
AIM: To evaluate the effect of thoracic radiation therapy (TRT) in elderly patients (aged ≥65 years) with extensive-stage small-cell lung cancer (ES-SCLC). PATIENTS & METHODS: This study reviewed the records of 118 elderly patients with ES-SCLC (all with distant metastasis) through January 2006-December 2013. The patients were divided into either a chemotherapy (ChT)/TRT-combination group or a ChT-alone group. RESULTS: The median survival time and 3-year overall survival rates in the ChT/TRT group were significantly higher than those in the ChT-alone group (17...
February 24, 2017: Future Oncology
https://www.readbyqxmd.com/read/28321884/electromechanical-response-times-in-the-knee-muscles-in-young-and-old-women
#19
Agnieszka Szpala, Alicja Rutkowska-Kucharska
INTRODUCTION: The aim of the study was to compare electromechanical response times (total reaction time, TRT; pre-motor time, PMT; electromechanical delay) in the knee muscles in groups of young and older women during release of peak torque (PT). METHODS: Fifty women (one group approximately 20 years of age and the other approximately 60) participated in the study. PT and electromyographic activity were measured for flexors and extensors of the right and left knee in static conditions in response to a visual stimulus...
March 21, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28319665/synthesis-of-four-disulfide-insulin-analogs-via-sequential-disulfide-bond-formation
#20
Fangzhou Wu, John P Mayer, Vasily M Gelfanov, Fa Liu, Richard D DiMarchi
Naturally occurring, multiple cysteine-containing peptides are a structurally unique class of compounds with a wide range of therapeutic and diagnostic applications. The development of reliable, precise chemical methods for their preparation is of paramount importance to facilitate exploration of their utility. We report here a straightforward and effective approach based on stepwise, sequentially directed disulfide bond formation, exemplified by the synthesis of four-disulfide bond-containing insulin analogs...
March 27, 2017: Journal of Organic Chemistry
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