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https://www.readbyqxmd.com/read/28626308/relationship-between-trunk-function-evaluated-using-the-trunk-righting-test-and-physical-function-in-patients-with-knee-osteoarthritis
#1
Kazuaki Kinoshita, Kazunari Ishida, Masashi Hashimoto, Yuki Yoneda, Yuta Naka, Hideyuki Kitanishi, Hiroki Oyagi, Yuichi Hoshino, Masahiro Kurosaka, Nao Shibanuma
[Purpose] The present study was to validate the importance of the trunk function evaluated by trunk righting test (TRT) with motor function in patients with knee osteoarthritis (OA) and to show the clinical use of TRT. [Subjects and Methods] This study included 50 patients with knee osteoarthritis who underwent total knee arthroplasty in our hospital. Correlations between physical functional test, such as muscle strength, balance function, and performance and TRT were statistically evaluated. [Results] The independent factors for ipsilateral TRT were maximal isometric knee extensor strength test and ipsilateral step test...
June 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28625628/which-patients-with-es-sclc-are-most-likely-to-benefit-from-more-aggressive-radiotherapy-a-secondary-analysis-of-the-phase-iii-crest-trial
#2
Ben J Slotman, Corinne Faivre-Finn, Harm van Tinteren, Astrid Keijser, John Praag, Joost Knegjens, Matthew Hatton, Iris van Dam, Annija van der Leest, Bart Reymen, Jos Stigt, Kate Haslett, Devashish Tripathi, Egbert F Smit, Suresh Senan
INTRODUCTION: In ES-SCLC patients with residual intrathoracic disease after first-line chemotherapy, the addition of thoracic radiotherapy reduces the risk of intrathoracic recurrence, and improves 2-year survival. To identify patient subgroups for future trials investigating higher dose (extra)thoracic radiotherapy, we investigated the prognostic importance of number and sites of metastases in patients included in the CREST trial. MATERIALS/ METHODS: Additional data on sites and numbers of metastases were collected from individual records of 260 patients from the top 9 recruiting centers in the randomized CREST trial (53% of 495 study patients), which compared thoracic radiotherapy (TRT) to no TRT in ES-SCLC patients after any response to chemotherapy...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28602052/multicenter-retrospective-analysis-of-clinical-characteristics-treatment-patterns-and-outcomes-in-very-elderly-patients-with-diffuse-large-b-cell-lymphoma-the-korean-cancer-study-group-ly16-01
#3
Jung Hye Choi, Tae Min Kim, Hyo Jung Kim, Sung Ae Koh, Yeung-Chul Mun, Hye Jin Kang, Yun Hwa Jung, Hyeok Shim, So Young Chong, Der-Sheng Sun, Soonil Lee, Byeong Bae Park, Jung Hye Kwon, Seung-Hyun Nam, Jun Ho Yi, Young Jin Yuh, Jong-Youl Jin, Jae Joon Han, Seok-Hyun Kim
Purpose: The treatment strategy for elderly patients older than 80 years with diffuse large B-cell lymphoma (DLBCL) has not been established because of poor treatment tolerability and lack of data. Materials and Methods: This multicenter retrospective study was conducted to investigate clinical characteristics, treatment patterns and outcomes of patients older than 80 years who were diagnosed with DLBCL at 19 institutions in Korea between 2005 and 2016. Results: A total of 194 patients were identified (median age, 83...
June 9, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28584268/pulmonary-emphysema-is-a-risk-factor-for-radiation-pneumonitis-in-nsclc-patients-with-squamous-cell-carcinoma-after-thoracic-radiation-therapy
#4
Ziyang Zhou, Xiao Song, Ailu Wu, Hui Liu, Hongyu Wu, Qiongya Wu, Yu Liu, Yefei Li, Yong Cai, Shixiong Liang
Pulmonary emphysema (PE) has been demonstrated to have a high prevalence in patients with locally advanced non-small cell lung cancer (NSCLC). A total of 153 patients with locally advanced NSCLC were enrolled in this study to investigate the association between PE and radiation pneumonitis (RP) after definitive thoracic radiation therapy (TRT). The incidence of RP in Grade 2, 3 and 5 were 11.1%, 9.8% and 0.7%, respectively. Univariate analysis revealed that age, PE, forced vital capacity (FVC), arterial partial pressure of oxygen (PO2) and mean lung dose (MLD) were significantly associated with the risk of Grade ≥2 or Grade ≥3 RP in patients with squamous cell carcinoma (SCC, P < 0...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28573047/simultaneous-fluorescein-angiography-and-spectral-domain-optical-coherence-tomography-correlate-retinal-thickness-changes-to-vascular-abnormalities-in-an-in-vivo-mouse-model-of-retinopathy-of-prematurity
#5
Olachi J Mezu-Ndubuisi, Lauren K Taylor, Jamee A Schoephoerster
BACKGROUND: Retinopathy of prematurity (ROP) is a condition of abnormal retinal vascular development (RVD) in premature infants. Fluorescein angiography (FA) has depicted phases (early, mid, late, and mature) of RVD in oxygen-induced retinopathy (OIR) mice. We sought to establish the relationship between retinal structural and vascular changes using simultaneous FA and spectral domain optical coherence tomography (SD-OCT). METHOD: 63 mice were exposed to 77% oxygen at postnatal day 7 (P7) for 5 days, while 63 mice remained in room air (RA)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28549414/phase-i-ii-study-of-induction-chemotherapy-using-carboplatin-plus-irinotecan-and-sequential-thoracic-radiotherapy-trt-for-elderly-patients-with-limited-disease-small-cell-lung-cancer-ld-sclc-torg-0604
#6
Yuki Misumi, Hiroaki Okamoto, Jiichiro Sasaki, Noriyuki Masuda, Mari Ishii, Tsuneo Shimokawa, Yukio Hosomi, Yusuke Okuma, Makoto Nagamata, Takashi Ogura, Terufumi Kato, Masafumi Sata, Sakiko Otani, Akira Takakura, Koichi Minato, Yosuke Miura, Takuma Yokoyama, Saori Takata, Katsuhiko Naoki, Koshiro Watanabe
BACKGROUND: The role of irinotecan for elderly patients with LD-SCLC has been unclear, and the timing of TRT combined with chemotherapy has not been fully evaluated. METHODS: Patients aged > 70 years with untreated, measurable, LD-SCLC, performance status (PS) 0-2, and adequate organ function were eligible. Treatment consisted of induction with carboplatin on day 1 and irinotecan on days 1 and 8, every 21 days for 4 cycles, and sequential TRT (54Gy in 27 fractions)...
May 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28548282/estimating-the-effect-of-immortal-time-bias-in-urologic-research-a-case-example-of-testosterone-replacement-therapy
#7
Christopher J D Wallis, Refik Saskin, Steven A Narod, Calvin Law, Girish S Kulkarni, Arun Seth, Robert K Nam
OBJECTIVE: To quantify the effect of immortal-time bias in an observational study examining the effect of cumulative testosterone exposure on mortality. SUBJECTS AND METHODS: We used a population-based matched cohort study of men aged 66 and older newly treated with testosterone replacement therapy and matched-controls from 2007-2012 in Ontario, Canada to quantify the effects of immortal-time bias. We used generalized estimating equations to determine the association between cumulative testosterone replacement therapy exposure and mortality...
May 26, 2017: BJU International
https://www.readbyqxmd.com/read/28547759/blood-donors-attitudes-towards-voluntary-non-remunerated-donation-in-trinidad-and-tobago
#8
K S Charles, A Poon King, A Ramai, K Rajnath, D Ramkissoon, S Ramkissoon, C Ramlal, K Ramnarine, K Rampersad, G Legall, S Pooransingh, A D Chantry
OBJECTIVES: To assess the attitude towards voluntary non-remunerated blood donation among blood donors in Trinidad and Tobago (TRT). BACKGROUND: Blood donors in TRT are either family replacement (F/R, 87%) or remunerated (13%). There is chronic blood shortage and high seroreactivity for transfusion-transmissible infections (TTI) in donors. Converting existing to voluntary non-remunerated donors (VNRD) reduces the need to recruit news donors in achieving 100% VNRD...
May 26, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28545092/are-thermal-barriers-higher-in-deep-sea-turtle-nests
#9
Pilar Santidrián Tomillo, Luis Fonseca, Frank V Paladino, James R Spotila, Daniel Oro
Thermal tolerances are affected by the range of temperatures that species encounter in their habitat. Daniel Janzen hypothesized in his "Why mountain passes are higher in the tropics" that temperature gradients were effective barriers to animal movements where climatic uniformity was high. Sea turtles bury their eggs providing some thermal stability that varies with depth. We assessed the relationship between thermal uniformity and thermal tolerance in nests of three species of sea turtles. We considered that barriers were "high" when small thermal changes had comparatively large effects and "low" when the effects were small...
2017: PloS One
https://www.readbyqxmd.com/read/28540225/testosterone-deficiency-in-adults-and-corresponding-treatment-patterns-across-the-globe
#10
REVIEW
James Anaissie, Kent J DeLay, William Wang, Georgios Hatzichristodoulou, Wayne J Hellstrom
The global prevalence of testosterone deficiency (TD) ranges from 10-40%. The actual diagnosis of TD is controversial, as a wide range of total testosterone (TT) thresholds are used for diagnosis (200-400 ng/dL), and physicians differ in their emphasis placed on clinical symptoms. There are also significant global differences in the prescription patterns of testosterone replacement therapy (TRT). In the United States, prescription of TRT is significantly higher than the rest of the world, increasing 3-fold over the last 10 years and more so in eugonadal men...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28522646/mr-spectroscopy-of-hepatic-fat-and-adiponectin-and-leptin-levels-during-testosterone-therapy-in-type-2-diabetes-a-randomized-double-blinded-placebo-controlled-trial
#11
Line Velling Magnussen, Poul Erik Andersen, Anabel Diaz, Jelena Markovic Ostojic, Kurt Højlund, David M Hougaard, Anders Nymark Christensen, Torben Leo Nielsen, Marianne Skovsager Andersen
BACKGROUND: Men with type 2 diabetes mellitus (T2D) often have lowered testosterone levels and an increased risk of cardiovascular disease (CVD). Ectopic fat increases the risk of CVD, whereas subcutaneous gluteofemoral fat protects against CVD and has a beneficial adipokine secreting profile. HYPOTHESIS: Testosterone replacement therapy (TRT) may reduce the content of ectopic fat and improve the adipokine profile in men with T2D. DESIGN AND METHODS: A randomized, double-blinded, placebo-controlled study in 39 men aged 50-70 years with T2D and bioavailable testosterone levels <7...
May 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28513492/repeatability-and-agreement-of-five-imaging-systems-for-measuring-anterior-segment-parameters-in-healthy-eyes
#12
Mukesh Kumar, Rohit Shetty, Chaitra Jayadev, Harsha L Rao, Debarun Dutta
PURPOSE: The purpose of this study is to assess the repeatability and agreement of five imaging devices, namely, the Pentacam (Oculus), Sirius (CSO), Orbscan IIz (Bausch and Lomb), Corvis (Oculus), and ultrasound pachymetry (UP, Tomey) in measuring steep keratometry (sKm), flat keratometry (fKm), central corneal thickness (CCT), thinnest corneal thickness (TCT), and anterior chamber depth (ACD) in healthy individuals. DESIGN: This was prospective, comparative study...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28497534/effects-of-testosterone-replacement-therapy-on-metabolic-syndrome-among-japanese-hypogonadal-men-a-subanalysis-of-a-prospective-randomised-controlled-trial-earth-study
#13
K Shigehara, H Konaka, T Nohara, K Izumi, Y Kitagawa, Y Kadono, T Iwamoto, E Koh, A Mizokami, M Namiki
We investigated the effects of testosterone replacement therapy (TRT) on metabolic factors among hypogonadal men with a metabolic syndrome. From the study population of the EARTH study, which was a randomised controlled study in Japan, 65 hypogonadal patients with a metabolic syndrome, comprising the TRT group (n = 32) and controls (n = 33), were included in this study analysis. The TRT group was administered 250 mg of testosterone enanthate as an intramuscular injection every 4 weeks for 12 months...
May 12, 2017: Andrologia
https://www.readbyqxmd.com/read/28494459/influence-of-bovine-serum-lipids-and-fetal-bovine-serum-on-the-expression-of-cell-surface-markers-in-cultured-bovine-preadipocytes
#14
Mansur A Sandhu, Sandra Jurek, Susanne Trappe, Martin Kolisek, Gerhard Sponder, Jörg R Aschenbach
To establish the influence of fetal bovine serum (FBS) and bovine serum lipids (BSL) on cell differentiation marker expression, bovine adipose-derived stem cells from subcutaneous tissue were incubated for 14 days in 4 types of differentiation media containing 10% FBS and 10 µL/mL BSL (TRT-1), no FBS and 10 µL/mL of BSL (TRT-2), 10% FBS and no BSL (TRT-3), or no supplements (TRT-4). Cells were subjected to Nile red staining, immunocytochemistry (CD73, CD90, CD105, DLK1, FabP4), and quantitative real-time PCR (CD73, CD90, CD105, FabP4)...
May 12, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28487389/normalization-of-testosterone-levels-after-testosterone-replacement-therapy-is-associated-with-decreased-incidence-of-atrial-fibrillation
#15
Rishi Sharma, Olurinde A Oni, Kamal Gupta, Mukut Sharma, Ram Sharma, Vikas Singh, Deepak Parashara, Surineni Kamalakar, Buddhadeb Dawn, Guoqing Chen, John A Ambrose, Rajat S Barua
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac dysrhythmia associated with significant morbidity and mortality. Several small studies have reported that low serum total testosterone (TT) levels were associated with a higher incidence of AF. In contrast, it is also reported that anabolic steroid use is associated with an increase in the risk of AF. To date, no study has explored the effect of testosterone normalization on new incidence of AF after testosterone replacement therapy (TRT) in patients with low testosterone...
May 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28472560/nedaplatin-and-irinotecan-with-concurrent-thoracic-radiotherapy-followed-by-docetaxel-consolidation-in-patients-with-locally-advanced-non-small-cell-lung-cancer
#16
Fumihiro Oshita, Shuji Murakami, Tetsuro Kondo, Haruhiro Saito, Kouzo Yamada, Yuko Nakayama
OBJECTIVE: We conducted a phase II study of nedaplatin (NP) and irinotecan (CPT) with concurrent thoracic radiotherapy (TRT) followed by docetaxel for locally advanced non-small cell lung cancer (NSCLC) to determine the safety and efficacy of the treatment. Patients with stage IIIA or IIIB NSCLC were treated with 3 cycles of chemotherapy comprising NP at 50 mg/m(2) and CPT at 50 mg/m(2) on days 1 and 8 every 4 weeks with concurrent TRT (2 Gy/day, total 66 Gy) followed by 3 cycles of docetaxel at 60 mg/m(2) on day 1 every 3 weeks...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28463538/targeted-radionuclide-therapy-an-evolution-toward-precision-cancer-treatment
#17
Hossein Jadvar
OBJECTIVE: This article reviews recent developments in targeted radionuclide therapy (TRT) approaches directed to malignant liver lesions, bone metastases, neuroendocrine tumors, and castrate-resistant metastatic prostate cancer and discusses challenges and opportunities in this field. CONCLUSION: TRT has been employed since the first radioiodine thyroid treatment almost 75 years ago. Progress in the understanding of the complex underlying biology of cancer and advances in radiochemistry science, multimodal imaging techniques including the concept of "see and treat" within the framework of theranostics, and universal traction with the notion of precision medicine have all contributed to a resurgence of TRT...
May 2, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28459143/testosterone-deficiency-and-nocturia-a-review
#18
REVIEW
Kazuyoshi Shigehara, Koji Izumi, Atsushi Mizokami, Mikio Namiki
Nocturia causes lack of sleep and excessive daytime somnolence, reducing overall well-being, vitality, productivity, and mental health. Nocturia is significantly associated with testosterone deficiency, lower urinary tract symptoms (LUTS), and sleep disorders. The development of LUTS is commonly associated with testosterone deficiency in elderly men, and recent studies have suggested that testosterone has an ameliorative effect on nocturia. In hypogonadal men with nocturia, a negative feedback cycle can arise, in which testosterone deficiency leads to the development of nocturia, and nocturia contributes to the decline in testosterone levels...
April 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28450138/test-retest-reliability-of-prefrontal-transcranial-direct-current-stimulation-tdcs-effects-on-functional-mri-connectivity-in-healthy-subjects
#19
Jana Wörsching, Frank Padberg, Konstantin Helbich, Alkomiet Hasan, Lena Koch, Stephan Goerigk, Sophia Stoecklein, Birgit Ertl-Wagner, Daniel Keeser
Transcranial Direct Current Stimulation (tDCS) of the prefrontal cortex (PFC) can be used for probing functional brain connectivity and meets general interest as novel therapeutic intervention in psychiatric and neurological disorders. Along with a more extensive use, it is important to understand the interplay between neural systems and stimulation protocols requiring basic methodological work. Here, we examined the test-retest (TRT) characteristics of tDCS-induced modulations in resting-state functional-connectivity MRI (RS fcMRI)...
April 24, 2017: NeuroImage
https://www.readbyqxmd.com/read/28449887/sleep-deficiency-on-school-days-in-icelandic-youth-as-assessed-by-wrist-accelerometry
#20
Vaka Rognvaldsdottir, Sigridur L Gudmundsdottir, Robert J Brychta, Soffia M Hrafnkelsdottir, Sunna Gestsdottir, Sigurbjorn A Arngrimsson, Kong Y Chen, Erlingur Johannsson
AIMS: The purpose of this study was to objectively measure, with wrist-worn actigraphy, free-living sleeping patterns in Icelandic adolescents, and to compare sleep duration, sleep quality and clock times between school days (SchD) and non-school days (NSchD) and the association between sleep and body mass index (BMI). METHODS: A cross-sectional study on 15.9-year-old (±0.3) adolescents from six schools in Reykjavík, Iceland, took place in the spring of 2015. Free-living sleep was measured on 301 subjects (122 boys and 179 girls) over seven days using wrist-worn actigraphy accelerometers...
May 2017: Sleep Medicine
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