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https://www.readbyqxmd.com/read/29334271/the-safety-of-available-treatments-of-male-hypogonadism-in-organic-and-functional-hypogonadism
#1
G Corona, G Rastrelli, Y Reisman, A Sforza, M Maggi
In the case of primary male hypogonadism (HG), only testosterone (T) replacement therapy (TRT) is possible whereas when the problem is secondary to a pituitary or hypothalamus alteration both T production and fertility can be, theoretically, restored. We here systematically reviewed and discussed the advantages and limits of medications formally approved for the treatment of HG. Areas covered: Data derived from available meta-analyses of placebo controlled randomized trials (RCTs) were considered and analyzed...
January 15, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29324887/the-tracked-roaming-transect-and-distance-sampling-methods-increase-the-efficiency-of-underwater-visual-censuses
#2
Alejo J Irigoyen, Irene Rojo, Antonio Calò, Gastón Trobbiani, Noela Sánchez-Carnero, José A García-Charton
Underwater visual census (UVC) is the most common approach for estimating diversity, abundance and size of reef fishes in shallow and clear waters. Abundance estimation through UVC is particularly problematic in species occurring at low densities and/or highly aggregated because of their high variability at both spatial and temporal scales. The statistical power of experiments involving UVC techniques may be increased by augmenting the number of replicates or the area surveyed. In this work we present and test the efficiency of an UVC method based on diver towed GPS, the Tracked Roaming Transect (TRT), designed to maximize transect length (and thus the surveyed area) with respect to diving time invested in monitoring, as compared to Conventional Strip Transects (CST)...
2018: PloS One
https://www.readbyqxmd.com/read/29321947/portal-vein-thrombosis-due-to-an-increase-in-dose-of-testosterone-in-a-young-man-with-klinefelter-syndrome
#3
Waseem Amjad, Salma Khatoon, Twara Tarasaria, Gulru Sharifova
Klinefelter syndrome (KS) is associated with increased incidence of thrombotic events. Hypofibrinolysis is associated with increased risk of thromboembolism. Although testosterone replacement therapy (TRT) inhibits the hypofibrinolysis, it can still cause thrombosis paradoxically due to increased dose and duration of use. Herein, we present a case of a young male diagnosed with KS who was taking testosterone. The dose was increased to boost the energy levels, and the patient presented with abdominal pain. Computed tomography (CT) of the abdomen showed extensive portal vein thrombosis...
November 6, 2017: Curēus
https://www.readbyqxmd.com/read/29316103/easy-to-attach-detach-solubilizing-tag-aided-chemical-synthesis-of-an-aggregative-capsid-protein
#4
Shugo Tsuda, Masayoshi Mochizuki, Hiroyuki Ishiba, Kumiko Yoshizawa-Kumagaye, Hideki Nishio, Shinya Oishi, Taku Yoshiya
A solubilizing "Trt-K10" tag was developed for the effective chemical preparation of peptides/proteins with low solubility. The Trt-K10 tag comprises a hydrophilic oligo-Lys sequence and a trityl anchor, and can be selectively introduced to a side chain thiol of Cys of deprotected peptides/proteins with a trityl alcohol-type introducing reagent "Trt(OH)-K10" under acidic conditions. Significantly, the ligation product in the reaction mixture of a thiol-additive-free native chemical ligation can be modified directly in a one-pot manner to facilitate the isolation of the product by high-performance liquid chromatography...
January 6, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29312641/impact-of-epidermal-growth-factor-receptor-sensitizing-mutations-on-outcomes-of-patients-with-non-small-cell-lung-cancer-treated-with-definitive-thoracic-radiation-therapy-a-systematic-review-and-meta-analysis
#5
Yu Yang Soon, Balamurugan Vellayappan, Jeremy Chee Seong Tey, Cheng Nang Leong, Wee Yao Koh, Ivan Weng Keong Tham
Background: To determine if the presence of epidermal growth factor receptor (EGFR) sensitizing mutations improves tumor control and survival outcomes in patients with non-metastatic non-small cell lung cancer (NSCLC) who received definitive thoracic radiation therapy (TRT) with or without chemotherapy. Materials and Methods: We searched MEDLINE for eligible comparative studies which compared the outcomes of patients treated with definitive TRT according to EGFR mutation status...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311520/validation-of-a-novel-timed-artificial-insemination-protocol-in-beef-cows-with-a-functional-corpus-luteum-detected-by-ultrasonography
#6
Hisashi Funakura, Ayumi Shiki, Yuji Tsubakishita, Shogo Mido, Hiromu Katamoto, Go Kitahara, Takeshi Osawa
This study aimed to clarify the feasibility of a novel timed artificial insemination (TAI) protocol using ultrasonography, and to determine the associations between the ovarian component and fertility. In Experiment 1,272 Japanese Black cows with a corpus luteum (CL) ≥ 18 mm in diameter were divided randomly into either the TRT group (134 cows that were administered gonadotropin-releasing hormone [GnRH] 56 h [day 2] after prostaglandin F2α [PGF] administration [day 0], followed by TAI 16-20 h later) or the CN-1 group (138 cows that were administered PGF followed by AI after estrus detection)...
January 5, 2018: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29310290/adsorptive-stripping-voltammetry-for-simultaneous-determination-of-hydrochlorothiazide-and-triamterene-in-hemodialysis-samples-using-a-multi-walled-carbon-nanotube-modified-glassy-carbon-electrode
#7
Felipe Fantinato Hudari, João Carlos Souza, Maria Valnice Boldrin Zanoni
Hemodialysis is the most commonly used method for the treatment of chronic kidney disease. In this procedure, some patients use diuretics to control weight gain and blood pressure. In this work, a voltammetric sensor based on a glassy carbon electrode modified with carbon nanotubes (GCE/MWCNT) is described for the simultaneous determination of the diuretics hydrochlorothiazide (HCT) and triamterene (TRT). The oxidation of the diuretics on the GCE/MWCNT surface was observed at 1.01 and 1.17V for HCT and TRT, respectively, allowing simultaneous determination, which was not possible with the unmodified glassy carbon electrode...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29290808/dosimetric-evaluation-of-radionuclides-for-vcam-1-targeted-radionuclide-therapy-of-early-brain-metastases
#8
Nadia Falzone, Nicole L Ackerman, Liset de la Fuente Rosales, Mario A Bernal, Xiaoxuan Liu, Sarah Gja Peeters, Manuel Sarmiento Soto, Aurélien Corroyer-Dulmont, Myriam Bernaudin, Elisa Grimoin, Omar Touzani, Nicola R Sibson, Katherine A Vallis
Brain metastases develop frequently in patients with breast cancer, and present a pressing therapeutic challenge. Expression of vascular cell adhesion molecule 1 (VCAM-1) is upregulated on brain endothelial cells during the early stages of metastasis and provides a target for the detection and treatment of early brain metastases. The aim of this study was to use a model of early brain metastasis to evaluate the efficacy of α-emitting radionuclides, 149Tb, 211At, 212Pb, 213Bi and 225Ac; β-emitting radionuclides, 90Y, 161Tb and 177Lu; and Auger electron (AE)-emitters 67Ga, 89Zr, 111In and 124I, for targeted radionuclide therapy (TRT)...
2018: Theranostics
https://www.readbyqxmd.com/read/29260422/teaching-recovery-techniques-evaluation-of-a-group-intervention-for-unaccompanied-refugee-minors-with-symptoms-of-ptsd-in-sweden
#9
Anna Sarkadi, Kajsa Ådahl, Emma Stenvall, Richard Ssegonja, Hemrin Batti, Parthena Gavra, Karin Fängström, Raziye Salari
In 2015, a total of 35,369 unaccompanied refugee minors (URMs) sought asylum in Sweden. In a previous study of 208 URMs, we found that 76% screened positive for PTSD. This study aimed to (1) evaluate the indicated prevention program Teaching Recovery Techniques (TRT) in a community setting and describe the program's effects on symptoms of PTSD and depression in URMs; and (2) examine participants' experiences of the program. The study included 10 groups. Methods for evaluation included the Children's Revised Impact of Event Scale (CRIES-8) and the Montgomery-Åsberg Depression Rating Scale Self-report (MADRS-S) at baseline and at post-intervention...
December 19, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29228638/thoracic-radiation-induced-pleural-effusion-and-risk-factors-in-patients-with-lung-cancer
#10
Jing Zhao, Regina M Day, Jian-Yue Jin, Leslie Quint, Hadyn Williams, Catherine Ferguson, Li Yan, Maurice King, Ahmad Albsheer, Martha Matuszak, Feng-Ming Spring Kong
The risk factors and potential practice implications of radiation-induced pleural effusion (RIPE) are undefined. This study examined lung cancer patients treated with thoracic radiation therapy (TRT) having follow-up computed tomography (CT) or 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT. Increased volumes of pleural effusion after TRT without evidence of tumor progression was considered RIPE. Parameters of lung dose-volume histogram including percent volumes irradiated with 5-55 Gy (V5-V55) and mean lung dose (MLD) were analyzed by receiver operating characteristic analysis...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227564/novel-mold-resistant-building-materials-impregnated-with-thermally-reduced-nano-silver
#11
Yen-Chi Chen, Kuo-Pin Yu, Wen-Cheng Shao, Chao-Heng Tseng, Wen-Chi Pan
In this study, we evaluated the long-term antifungal effectiveness of 3 types of interior building materials (gypsum board (GB), cement board (CB) and softwood plywood (S-PW)) impregnated with thermally reduced silver nanoparticles supported by titanium dioxide (AgNPs/TiO2 ) under 95% relative humidity for four weeks. AgNPs/TiO2 was synthesized at two thermal reduction temperatures (TRTs, 120 and 200°C) with two different AgNP weight percentages (2 and 5 wt%). Four different silver loading levels (SLLs, 0...
December 11, 2017: Indoor Air
https://www.readbyqxmd.com/read/29216720/testosterone-replacement-therapy-trt-and-its-effect-on-bone-marrow-how-serious-is-it-and-is-there-a-true-polyglobulia
#12
M Levcikova, J Breza, J Luha, J Dubravicky, E Kovacova, J Fillo
INTRODUCTION: TRT in men with testosterone deficiency syndrome (TDS) had multiple positive effects and restore a quality of life of affected men. Polyglobulia is the most common dose-limiting adverse effect of TRT, but the mechanisms of TRT-mediated erythropoesis remain unclear. In this study, we evaluated long term haematological side effects of TRT: polyglobulia, elevated hemoglobin (Hb) and haematocrit (Ht). METHODS: In a cross-sectional descriptive study, the authors treated 69 men with TDS and the average age 59 years and the follow-up period 81...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29205178/association-of-subcutaneous-testosterone-pellet-therapy-with-developing-secondary-polycythemia
#13
Katherine Lang Rotker, Michael Alavian, Bethany Nelson, Grayson L Baird, Martin M Miner, Mark Sigman, Kathleen Hwang
A variety of methods for testosterone replacement therapy (TRT) exist, and the major potential risks of TRT have been well established. The risk of developing polycythemia secondary to exogenous testosterone (T) has been reported to range from 0.4% to 40%. Implantable T pellets have been used since 1972, and secondary polycythemia has been reported to be as low as 0.4% with this administration modality. However, our experience has suggested a higher rate. We conducted an institutional review board-approved, single-institution, retrospective chart review (2009-2013) to determine the rate of secondary polycythemia in 228 men treated with subcutaneously implanted testosterone pellets...
December 5, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29200082/pneumonitis-in-irradiated-lungs-after-nivolumab-a-brief-communication-and-review-of-the-literature
#14
Farkhad Manapov, Olarn Roengvoraphoj, Maurice Dantes, Sebastian Marschner, Minglun Li, Chukwuka Eze
Nivolumab is a feasible therapy option in patients with advanced non-small cell lung cancer (NSCLC) who progress on first-line treatment. However, there is limited information about an overlapping toxicity of PD-1 inhibitors when administered following thoracic radiotherapy (TRT). Three of 25 patients with advanced NSCLC were treated with palliative or curative intent. Nivolumab was initiated as second or third-line therapy after TRT for recurrent or progressive disease. All 3 patients developed grade 3 pneumonitis at some point during nivolumab therapy...
December 1, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29199702/palliative-thoracic-radiotherapy-in-advanced-lung-cancer-a-single-institution-experience
#15
C Hotwani, J P Agarwal, K Prabhash, A Munshi, A Joshi, S Misra, D Kumar, S Das, S G Laskar
BACKGROUND: Majority of patients of lung cancer present with locally advanced or metastatic disease, where systemic therapy is the treatment of choice. Many of these patients have local symptoms due to thoracic disease, wherein radiotherapy is proven to be an effective modality for alleviation of symptoms. However, the optimal dose of radiotherapy for adequate palliation remains debatable. The purpose of this retrospective study was to assess the efficacy of two different schedules of thoracic radiotherapy (TRT) with respect to symptom palliation...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29183245/variation-in-practice-pattern-of-male-hypogonadism-a-comparative-analysis-of-primary-care-urology-endocrinology-and-hiv-specialists
#16
Yash S Khandwala, Omer A Raheem, Mir Amaan Ali, Tung-Chin Hsieh
The objective of the current study was to measure the adherence of guideline-based evaluation and treatment of hypogonadism by medical specialty. A retrospective review was performed analyzing patients from a single academic institution within the past 10 years. The cohort of 193 men was grouped according to medical specialty of the diagnosing physician (50 urology, 49 primary care, 44 endocrinology, and 50 HIV medicine). Adherence to guidelines was assessed using the Endocrine Society's criteria. Primary care patients were older compared to the rest of the cohort ( p < ...
November 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/29174614/marketing-and-testosterone-treatment-in-the-usa-a-systematic-review
#17
REVIEW
Jathin Bandari, Omar M Ayyash, Sherry L Emery, Charles B Wessel, Benjamin J Davies
CONTEXT: Testosterone replacement therapy (TRT) is currently approved by the Food and Drug Administration only for classic hypogonadism, although off-label indications have resulted in a dramatic expansion in prescriptions in the USA. Marketing may significantly affect prescriber behavior. OBJECTIVE: To systematically review all available evidence on marketing and TRT in the USA. EVIDENCE ACQUISITION: PubMed, Embase, and Scopus were searched up to July 2017 for all relevant publications reporting on assessments of the TRT market size, economic costs associated with hypogonadism, trends in TRT prescriptions, drug discontinuation rates, and advertising and sales efforts in the USA...
November 22, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29158844/quantitative-imaging-for-targeted-radionuclide-therapy-dosimetry-technical-review
#18
REVIEW
Tiantian Li, Edwin C I Ao, Bieke Lambert, Boudewijn Brans, Stefaan Vandenberghe, Greta S P Mok
Targeted radionuclide therapy (TRT) is a promising technique for cancer therapy. However, in order to deliver the required dose to the tumor, minimize potential toxicity in normal organs, as well as monitor therapeutic effects, it is important to assess the individualized internal dosimetry based on patient-specific data. Advanced imaging techniques, especially radionuclide imaging, can be used to determine the spatial distribution of administered tracers for calculating the organ-absorbed dose. While planar scintigraphy is still the mainstream imaging method, SPECT, PET and bremsstrahlung imaging have promising properties to improve accuracy in quantification...
2017: Theranostics
https://www.readbyqxmd.com/read/29157335/hyperoxia-and-hypoxic-hypoxia-effects-on-simple-and-choice-reaction-times
#19
Todd Dart, Megan Gallo, Jeremy Beer, Joseph Fischer, Thomas Morgan, Andrew Pilmanis
INTRODUCTION: Effects of exposure to hyperoxia (PiO2 > 105 mmHg), normoxia (PiO2 95-105 mmHg) and hypoxia (PiO2 < 95 mmHg) on simple and choice reaction performance tasks were evaluated. METHODS: Ten subjects performed simple and choice reaction time tests (SRT and CRT, respectively) at ground level for 40 min (20 min normoxic, 20 min hyperoxic, randomly assigned), 3048 m (10,000 ft) for 75 min (15 min hyperoxic, 60 min hypoxic), 4572 m (15,000 ft) for 60 min (15 min hyperoxic, 45 min hypoxic), and 6096 m (20,000 ft) for 35 min (15 min hyperoxic, 20 min hypoxic)...
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29152036/case-study-quasi-qualitative-analysis-of-peer-group-supervision-of-a-child-trauma-recovery-program-in-occupied-palestine
#20
Ian G Barron, Ghassan Abdallah, Unni Heltne
This case study explores the impact of peer group supervision (PGS) for counselors delivering Teaching Recovery Techniques (TRT), a group psycho-social program for traumatized adolescents. Interviews were conducted with seven school counselors, from villages near East Jerusalem in occupied Palestine; a skilled supervisor; and an international trainer. A quasi-qualitative analysis was conducted to quantify responses and themes along with a measure of inter-rater reliability. Participants reported that even in a context of military violence, PGS provided a reflective process inclusive of formative, normative and restorative functions...
2017: Journal of Child & Adolescent Trauma
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