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https://www.readbyqxmd.com/read/28522646/mr-spectroscopy-of-hepatic-fat-and-adiponectin-and-leptin-levels-during-testosterone-therapy-in-type-2-diabetes-a-randomized-double-blinded-placebo-controlled-trial
#1
Line Velling Magnussen, Poul Erik Andersen, Anabel Diaz, Jelena Markovic Ostojic, Kurt Højlund, David M Hougaard, Anders Nymark Christensen, Torben Leo Nielsen, Marianne Skovsager Andersen
BACKGROUND: Men with type 2 diabetes mellitus (T2D) often have lowered testosterone levels and an increased risk of cardiovascular disease (CVD). Ectopic fat increases the risk of CVD, whereas subcutaneous gluteofemoral fat protects against CVD and has a beneficial adipokine secreting profile. HYPOTHESIS: Testosterone replacement therapy (TRT) may reduce the content of ectopic fat and improve the adipokine profile in men with T2D. DESIGN AND METHODS: A randomized, double-blinded, placebo-controlled study in 39 men aged 50-70 years with T2D and bioavailable testosterone levels <7...
May 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28513492/repeatability-and-agreement-of-five-imaging-systems-for-measuring-anterior-segment-parameters-in-healthy-eyes
#2
Mukesh Kumar, Rohit Shetty, Chaitra Jayadev, Harsha L Rao, Debarun Dutta
PURPOSE: The purpose of this study is to assess the repeatability and agreement of five imaging devices, namely, the Pentacam (Oculus), Sirius (CSO), Orbscan IIz (Bausch and Lomb), Corvis (Oculus), and ultrasound pachymetry (UP, Tomey) in measuring steep keratometry (sKm), flat keratometry (fKm), central corneal thickness (CCT), thinnest corneal thickness (TCT), and anterior chamber depth (ACD) in healthy individuals. DESIGN: This was prospective, comparative study...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28497534/effects-of-testosterone-replacement-therapy-on-metabolic-syndrome-among-japanese-hypogonadal-men-a-subanalysis-of-a-prospective-randomised-controlled-trial-earth-study
#3
K Shigehara, H Konaka, T Nohara, K Izumi, Y Kitagawa, Y Kadono, T Iwamoto, E Koh, A Mizokami, M Namiki
We investigated the effects of testosterone replacement therapy (TRT) on metabolic factors among hypogonadal men with a metabolic syndrome. From the study population of the EARTH study, which was a randomised controlled study in Japan, 65 hypogonadal patients with a metabolic syndrome, comprising the TRT group (n = 32) and controls (n = 33), were included in this study analysis. The TRT group was administered 250 mg of testosterone enanthate as an intramuscular injection every 4 weeks for 12 months...
May 12, 2017: Andrologia
https://www.readbyqxmd.com/read/28494459/influence-of-bovine-serum-lipids-and-fetal-bovine-serum-on-the-expression-of-cell-surface-markers-in-cultured-bovine-preadipocytes
#4
Mansur A Sandhu, Sandra Jurek, Susanne Trappe, Martin Kolisek, Gerhard Sponder, Jörg R Aschenbach
To establish the influence of fetal bovine serum (FBS) and bovine serum lipids (BSL) on cell differentiation marker expression, bovine adipose-derived stem cells from subcutaneous tissue were incubated for 14 days in 4 types of differentiation media containing 10% FBS and 10 µL/mL BSL (TRT-1), no FBS and 10 µL/mL of BSL (TRT-2), 10% FBS and no BSL (TRT-3), or no supplements (TRT-4). Cells were subjected to Nile red staining, immunocytochemistry (CD73, CD90, CD105, DLK1, FabP4), and quantitative real-time PCR (CD73, CD90, CD105, FabP4)...
May 12, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28487389/normalization-of-testosterone-levels-after-testosterone-replacement-therapy-is-associated-with-decreased-incidence-of-atrial-fibrillation
#5
Rishi Sharma, Olurinde A Oni, Kamal Gupta, Mukut Sharma, Ram Sharma, Vikas Singh, Deepak Parashara, Surineni Kamalakar, Buddhadeb Dawn, Guoqing Chen, John A Ambrose, Rajat S Barua
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac dysrhythmia associated with significant morbidity and mortality. Several small studies have reported that low serum total testosterone (TT) levels were associated with a higher incidence of AF. In contrast, it is also reported that anabolic steroid use is associated with an increase in the risk of AF. To date, no study has explored the effect of testosterone normalization on new incidence of AF after testosterone replacement therapy (TRT) in patients with low testosterone...
May 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28472560/nedaplatin-and-irinotecan-with-concurrent-thoracic-radiotherapy-followed-by-docetaxel-consolidation-in-patients-with-locally-advanced-non-small-cell-lung-cancer
#6
Fumihiro Oshita, Shuji Murakami, Tetsuro Kondo, Haruhiro Saito, Kouzo Yamada, Yuko Nakayama
OBJECTIVE: We conducted a phase II study of nedaplatin (NP) and irinotecan (CPT) with concurrent thoracic radiotherapy (TRT) followed by docetaxel for locally advanced non-small cell lung cancer (NSCLC) to determine the safety and efficacy of the treatment. Patients with stage IIIA or IIIB NSCLC were treated with 3 cycles of chemotherapy comprising NP at 50 mg/m(2) and CPT at 50 mg/m(2) on days 1 and 8 every 4 weeks with concurrent TRT (2 Gy/day, total 66 Gy) followed by 3 cycles of docetaxel at 60 mg/m(2) on day 1 every 3 weeks...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28463538/targeted-radionuclide-therapy-an-evolution-toward-precision-cancer-treatment
#7
Hossein Jadvar
OBJECTIVE: This article reviews recent developments in targeted radionuclide therapy (TRT) approaches directed to malignant liver lesions, bone metastases, neuroendocrine tumors, and castrate-resistant metastatic prostate cancer and discusses challenges and opportunities in this field. CONCLUSION: TRT has been employed since the first radioiodine thyroid treatment almost 75 years ago. Progress in the understanding of the complex underlying biology of cancer and advances in radiochemistry science, multimodal imaging techniques including the concept of "see and treat" within the framework of theranostics, and universal traction with the notion of precision medicine have all contributed to a resurgence of TRT...
May 2, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28459143/testosterone-deficiency-and-nocturia-a-review
#8
REVIEW
Kazuyoshi Shigehara, Koji Izumi, Atsushi Mizokami, Mikio Namiki
Nocturia causes lack of sleep and excessive daytime somnolence, reducing overall well-being, vitality, productivity, and mental health. Nocturia is significantly associated with testosterone deficiency, lower urinary tract symptoms (LUTS), and sleep disorders. The development of LUTS is commonly associated with testosterone deficiency in elderly men, and recent studies have suggested that testosterone has an ameliorative effect on nocturia. In hypogonadal men with nocturia, a negative feedback cycle can arise, in which testosterone deficiency leads to the development of nocturia, and nocturia contributes to the decline in testosterone levels...
April 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28450138/test-retest-reliability-of-prefrontal-transcranial-direct-current-stimulation-tdcs-effects-on-functional-mri-connectivity-in-healthy-subjects
#9
Jana Wörsching, Frank Padberg, Konstantin Helbich, Alkomiet Hasan, Lena Koch, Stephan Goerigk, Sophia Stoecklein, Birgit Ertl-Wagner, Daniel Keeser
Transcranial Direct Current Stimulation (tDCS) of the prefrontal cortex (PFC) can be used for probing functional brain connectivity and meets general interest as novel therapeutic intervention in psychiatric and neurological disorders. Along with a more extensive use, it is important to understand the interplay between neural systems and stimulation protocols requiring basic methodological work. Here, we examined the test-retest (TRT) characteristics of tDCS-induced modulations in resting-state functional-connectivity MRI (RS fcMRI)...
April 24, 2017: NeuroImage
https://www.readbyqxmd.com/read/28449887/sleep-deficiency-on-school-days-in-icelandic-youth-as-assessed-by-wrist-accelerometry
#10
Vaka Rognvaldsdottir, Sigridur L Gudmundsdottir, Robert J Brychta, Soffia M Hrafnkelsdottir, Sunna Gestsdottir, Sigurbjorn A Arngrimsson, Kong Y Chen, Erlingur Johannsson
AIMS: The purpose of this study was to objectively measure, with wrist-worn actigraphy, free-living sleeping patterns in Icelandic adolescents, and to compare sleep duration, sleep quality and clock times between school days (SchD) and non-school days (NSchD) and the association between sleep and body mass index (BMI). METHODS: A cross-sectional study on 15.9-year-old (±0.3) adolescents from six schools in Reykjavík, Iceland, took place in the spring of 2015. Free-living sleep was measured on 301 subjects (122 boys and 179 girls) over seven days using wrist-worn actigraphy accelerometers...
May 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28447913/testosterone-replacement-therapy-and-risk-of-favorable-and-aggressive-prostate-cancer
#11
Stacy Loeb, Yasin Folkvaljon, Jan-Erik Damber, Joseph Alukal, Mats Lambe, Pär Stattin
Purpose The association between exposure to testosterone replacement therapy (TRT) and prostate cancer risk is controversial. The objective was to examine this association through nationwide, population-based registry data. Methods We performed a nested case-control study in the National Prostate Cancer Register of Sweden, which includes all 38,570 prostate cancer cases diagnosed from 2009 to 2012, and 192,838 age-matched men free of prostate cancer. Multivariable conditional logistic regression was used to examine associations between TRT and risk of prostate cancer (overall, favorable, and aggressive)...
May 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28434756/evaluation-of-tinnitus-retraining-therapy-for-patients-with-normal-audiograms-versus-patients-with-hearing-loss
#12
Kana Lee, Kunihiko Makino, Kohei Yamahara
OBJECTIVE: A few chronic tinnitus patients show normal hearing thresholds in the pure tone audiometry from 125Hz to 8000Hz (≤20dB). We report the characteristics of the course of those patients underwent tinnitus retraining therapy (TRT) compared with other patients suffering from chronic and severe tinnitus. METHODS: We identified 13 patients with normal hearing thresholds among 242 patients suffering over 3 months, Tinnitus Handicap Inventory (THI) ≥16/100, and follow up period is over 6 months...
April 20, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28422383/liquid-and-subcritical-fluid-chromatographic-enantioseparation-of-n-%C3%AE-fmoc-proteinogenic-amino-acids-on-quinidine-based-zwitterionic-and-anion-exchanger-type-chiral-stationary-phases-a-comparative-study
#13
Gyula Lajkó, Nóra Grecsó, Gábor Tóth, Ferenc Fülöp, Wolfgang Lindner, István Ilisz, Antal Péter
Stereoselective high-performance liquid chromatographic and subcritical fluid chromatographic separations of 19 N(α) -Fmoc proteinogenic amino acid enantiomers were carried out by using Quinidine-based zwitterionic and anion-exchanger-type chiral stationary phases Chiralpak ZWIX(-) and QD-AX. For optimization of retention and enantioselectivity, the ratio of bulk solvent components (MeOH/MeCN, H2 O/MeOH, or CO2 /MeOH) and the nature and concentration of the acid and base additives (counter- and co-ions) were systematically varied...
April 19, 2017: Chirality
https://www.readbyqxmd.com/read/28418420/selective-purification-and-chemical-labeling-of-a-target-protein-on-ruthenium-photocatalyst-functionalized-affinity-beads
#14
Michihiko Tsushima, Shinichi Sato, Hiroyuki Nakamura
Selective purification and chemical labeling of a target protein in a protein mixture were simultaneously achieved on the surface of affinity beads functionalized with ligands, such as benzenesulfonamide and methotrexate (MTX), and a ruthenium complex containing 2,2'-bipyridine-4,4'-dicarboxylic acid (dcbpy). Chemical labeling of the target protein with a tyrosine radical trapper (TRT) proceeded on the surface of the beads when the target protein was in close proximity to the ruthenium photocatalyst. Both the protein purification and chemical labeling abilities of the affinity beads functionalized with ruthenium photocatalyst were not compromised after recycling several times...
April 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28410143/targeted-radionuclide-therapy-frontiers-in-theranostics
#15
Francesca Gallivanone, Mauro Valente, Annarita Savi, Carla Canevari, Isabella Castiglioni
The concept of targeted radionuclide therapy (TRT) relies on the use of injected nuclear medicine as treating agents, targeted at the cellular or molecular level. The growth of the interest in TRT was stimulated by the advances in radionuclide production and labeling as well as by the improvement in the knowledge of appropriate and specific molecular targets. In recent years, different studies on TRT were focused on the evaluation of radionuclide compounds able to combine imaging of the disease with TRT, in a theranostic approach...
June 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28394396/effects-of-immunomodulatory-nutrients-on-growth-performance-and-immune-related-gene-expression-in-layer-chicks-challenged-with-lipopolysaccharide
#16
E L Wils-Plotz, K C Klasing
Immunomodulatory nutrients alter the immune response to pathogens. This study was conducted to determine the effects of immunomodulatory nutrients on the immune response to a lipopolysaccharide (LPS) challenge of layer chicks fed supplemental corn oil (control; 3%), fish oil (3%), conjugated linoleic acid (CLA; 1%), lutein (0.05 g/kg), or vitamin E (90 I.U./ kg). Four-week-old layer chicks were allotted to 10 treatment groups arranged as a 2 × 5 factorial with 2 sexes and 5 dietary treatments (TRT; 5 replicate pens of 2 male and 2 female chicks per TRT)...
March 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28388868/equivalence-and-test-retest-reproducibility-of-conventional-and-extended-high-frequency-audiometric-thresholds-obtained-using-pure-tone-and-narrow-band-noise-stimuli
#17
Andrew B John, Brian M Kreisman
OBJECTIVES: Extended high-frequency (EHF) audiometry is useful for evaluating ototoxic exposures and may relate to speech recognition, localisation and hearing aid benefit. There is a need to determine whether common clinical practice for EHF audiometry using tone and noise stimuli is reliable. We evaluated equivalence and compared test-retest (TRT) reproducibility for audiometric thresholds obtained using pure tones and narrowband noise (NBN) from 0.25 to 16 kHz. DESIGN: Thresholds and test-retest reproducibility for stimuli in the conventional (0...
April 7, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28382303/evaluation-of-the-efficacy-of-cisplatin-etoposide-and-the-role-of-thoracic-radiotherapy-and-prophylactic-cranial-irradiation-in-lcnec
#18
Arsela Prelaj, Sara Elena Rebuzzi, Gabriella Del Bene, Julio Rodrigo Giròn Berrìos, Alessandra Emiliani, Lucilla De Filippis, Alessandra Anna Prete, Silvia Pecorari, Gaia Manna, Carla Ferrara, Daniele Rossini, Flavia Longo
In small-cell lung cancer (SCLC), the role of chemotherapy and radiotherapy is well established. Large-cell neuroendocrine carcinoma (LCNEC) shares several clinicopathological features with SCLC, but its optimal therapy is not defined. We evaluated clinical response and survival outcomes of advanced LCNEC treated in first-line therapy compared with SCLC. 72 patients with stage III-IV LCNEC (n=28) and extensive-stage SCLC (ES-SCLC) (n=44) received cisplatin-etoposide with/without thoracic radiotherapy (TRT) and prophylactic cranial irradiation (PCI)...
January 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28377392/effects-of-testosterone-and-evoked-resistance-exercise-after-spinal-cord-injury-terex-sci-study-protocol-for-a-randomised-controlled-trial
#19
Ashraf S Gorgey, Refka E Khalil, Ranjodh Gill, Laura C O'Brien, Timothy Lavis, Teodoro Castillo, David X Cifu, Jeannie Savas, Rehan Khan, Christopher Cardozo, Edward J Lesnefsky, David R Gater, Robert A Adler
INTRODUCTION: Individuals with spinal cord injury (SCI) are at a lifelong risk of obesity and chronic metabolic disorders including insulin resistance and dyslipidemia. Within a few weeks of injury, there is a significant decline in whole body fat-free mass, particularly lower extremity skeletal muscle mass, and subsequent increase in fat mass (FM). This is accompanied by a decrease in anabolic hormones including testosterone. Testosterone replacement therapy (TRT) has been shown to increase skeletal muscle mass and improve metabolic profile...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28361372/state-of-the-art-a-review-of-cardiovascular-effects-of-testosterone-replacement-therapy-in-adult-males
#20
REVIEW
Ahmed Elsherbiny, Matthew Tricomi, Digant Bhatt, Hari Kumar Dandapantula
PURPOSE OF REVIEW: According to an Endocrine Society Clinical Practice Guideline published in June 2010, testosterone replacement therapy (TRT) should be administered only to men who are hypogonadal with documented low testosterone level on two morning measurements. This recommendation was based on previous studies that did not show an increased risk in cardiovascular events with TRT. In contrast, recent studies did show an increased risk which prompted the FDA to investigate further...
April 2017: Current Cardiology Reports
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