keyword
MENU ▼
Read by QxMD icon Read
search

Trt

keyword
https://www.readbyqxmd.com/read/27905300/intravital-imaging-of-mouse-urothelium-reveals-activation-of-extracellular-signal-regulated-kinase-by-stretch-induced-intravesical-release-of-atp
#1
Takeshi Sano, Takashi Kobayashi, Hiromitsu Negoro, Atsushi Sengiku, Takuya Hiratsuka, Yuji Kamioka, Louis S Liou, Osamu Ogawa, Michiyuki Matsuda
To better understand the roles played by signaling molecules in the bladder, we established a protocol of intravital imaging of the bladder of mice expressing a Förster/fluorescence resonance energy transfer (FRET) biosensor for extracellular signal-regulated kinase (ERK), which plays critical roles not only in cell growth but also stress responses. With an upright two-photon excitation microscope and a vacuum-stabilized imaging window, cellular ERK activity was visualized in the whole bladder wall, from adventitia to urothelium...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27877888/lysosomal-ph-inducible-supramolecular-dissociation-of-polyrotaxanes-possessing-acid-labile-n-triphenylmethyl-end-groups-and-their-therapeutic-potential-for-niemann-pick-type-c-disease
#2
Atsushi Tamura, Kei Nishida, Nobuhiko Yui
Niemann-Pick type C (NPC) disease is characterized by the accumulation of cholesterol in lysosomes. We have previously reported that biocleavable polyrotaxanes (PRXs) composed of β-cyclodextrins (β-CDs) threaded onto a linear polymer capped with bulky stopper molecules via intracellularly cleavable linkers show remarkable cholesterol reducing effects in NPC disease patient-derived fibroblasts owing to the stimuli-responsive intracellular dissociation of PRXs and subsequent β-CD release from the PRXs. Herein, we describe a series of novel acid-labile 2-(2-hydroxyethoxy)ethyl group-modified PRXs (HEE-PRXs) bearing terminal N-triphenylmethyl (N-Trt) groups as a cleavable component for the treatment of NPC disease...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27877216/investigating-a-correlation-between-chemoradiotherapy-schedule-parameters-and-overall-survival-in-a-real-life-ld-sclc-patient-cohort
#3
Farkhad Manapov, Chukwuka Eze, Maximilian Niyazi, Olarn Roengvoraphoj, Minglun Li, Nina-Sophie Hegemann, Guido Hildebrandt, Rainer Fietkau, Claus Belka
Background: Chemoradiotherapy (CRT) is a treatment standard in limited disease (LD) small cell lung cancer (SCLC). Currently, the timing of thoracic radiation therapy (TRT) remains the subject of randomised trials and meta-analyses. To investigate a correlation between CRT schedule parameters and overall survival (OS) in a real-life patient cohort, a temporal analysis was performed. Methods: 182 LD SCLC patients successfully treated with definitive CRT were retrospectively reviewed. TRT was applied concurrently or sequentially...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27859680/psychosocial-group-intervention-among-war-affected-children-an-analysis-of-changes-in-posttraumatic-cognitions
#4
Samuli Kangaslampi, Raija-Leena Punamäki, Samir Qouta, Marwan Diab, Kirsi Peltonen
Cognitive theories point to reduction in dysfunctional posttraumatic cognitions (PTCs) as one mechanism involved in recovery from posttraumatic stress symptoms (PTSS), yet research findings have shown individual differences in the recovery process. We tested the cognitive mediation hypothesis above in a previously published psychosocial group intervention among war-affected children. We also examined heterogeneity in children's PTCs during the intervention. We used a cluster randomized trial of Smith et al...
November 17, 2016: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/27818256/eurycoma-longifolia-as-a-potential-alternative-to-testosterone-for-the-treatment-of-osteoporosis-exploring-time-mannered-proliferative-differentiative-and-morphogenic-modulation-in-osteoblasts
#5
Hnin Ei Thu, Isa Naina Mohamed, Zahid Hussain, Ahmad Nazrun Shuid
ETHNOPHARMACOLOGICAL RELEVANCE: Eurycoma longifolia (EL) has been well-studied traditionally as a chief ingredient of many polyherbal formulations for the management of male osteoporosis. It has also been well-recognised to protect against bone calcium loss in orchidectomised rats. AIM OF THE STUDY: To evaluate the effects of EL on the time-mannered sequential proliferative, differentiative, and morphogenic modulation in osteoblasts compared with testosterone. MATERIALS AND METHODS: Cell proliferation was analysed using MTS assay and phase contrast microscopy...
November 3, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27794546/effects-of-coccidiosis-vaccination-administered-by-in-ovo-injection-on-the-hatchability-and-hatching-chick-quality-of-broilers
#6
A O Sokale, W Zhai, L M Pote, C J Williams, E D Peebles
Effects of the in ovo injection of a commercial coccidiosis vaccine on the hatchability and hatching chick quality variables of Ross × Ross 708 broilers were examined. Four treatment (TRT) groups were represented on each of 7 replicate tray levels of a single-stage incubator (28 TRT-replicate groups). Each TRT-replicate contained 63 eggs (1,764 total eggs). On d 18.5 of incubation, eggs were subjected to one of 4 TRT using a commercial multi-egg injector. Three control groups (non-injected, dry-punch, and diluent-injected) and one TRT group (injected with diluent containing Inovocox EM1 vaccine) were used...
October 28, 2016: Poultry Science
https://www.readbyqxmd.com/read/27789218/trends-in-testosterone-replacement-therapy-use-among-reproductive-age-us-men-2003-2013
#7
Pravin Kumar Rao, Sheree L Boulet, Akanksha Mehta, James Hotaling, Michael L Eisenberg, Stanton C Honig, Lee Warner, Dmitry M Kissin, Ajay K Nangia, Lawrence S Ross
PURPOSE: Although testosterone replacement therapy (TRT) use in the US has increased dramatically over the past decade, trends in TRT use among reproductive-aged men have not been investigated. We assessed changes in TRT use and practice patterns among 18-45-year-old US men from 2003-2013, and compared them to older men. MATERIALS AND METHODS: This is a retrospective, cross-sectional analysis of men ages 18-45 and 56-64 enrolled in the Truven Health MarketScan Commercial Claims Databases throughout each given calendar year from 2003-2013 (n=5,094,868 in 2013)...
October 24, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27785518/analysis-of-risk-factors-for-pulmonary-complications-in-patients-with-limited-stage-small-cell-lung-cancer-a-single-centre-retrospective-study
#8
Beata Sas-Korczyńska, Elżbieta Łuczyńska, Wojciech Kamzol, Andrzej Sokołowski
INTRODUCTION: The most effective therapy in patients with limited-stage small cell lung cancer (LS SCLC) seems to be chemotherapy (using platinum-based regimens) and thoracic radiotherapy (TRT), which is followed by prophylactic cranial irradiation. MATERIALS AND METHODS: The analysed group comprised 217 patients who received combined treatment for LS SCLC, i.e. chemotherapy (according to cisplatin and etoposide schedule) and TRT (concurrent in 101 and sequential in 116 patients)...
October 26, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27774779/testosterone-treatment-is-not-associated-with-increased-risk-of-adverse-cardiovascular-events-results-from-the-registry-of-hypogonadism-in-men-rhyme
#9
Mario Maggi, Frederick C W Wu, Thomas H Jones, Graham Jackson, Hermann M Behre, Geoffrey Hackett, Antonio Martin-Morales, Giancarlo Balercia, Adrian S Dobs, Stefan T E Arver, Marcello Maggio, Glenn R Cunningham, Andrea M Isidori, Richard Quinton, Olivia A Wheaton, Flora S Siami, Raymond C Rosen
AIMS: The aim of this study was to assess cardiovascular (CV) safety of testosterone replacement therapy (TRT) in a large, diverse cohort of European men with hypogonadism (HG). METHODS: The Registry of Hypogonadism in Men (RHYME) was designed as a multi-national, longitudinal disease registry of men diagnosed with hypogonadism (HG) at 25 clinical sites in six European countries. Data collection included a complete medical history, physical examination, blood sampling and patient questionnaires at multiple study visits over 2-3 years...
October 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27761361/paradoxical-delay-of-senescence-upon-depletion-of-brca2-in-telomerase-deficient-worms
#10
Mi-Sun Kwon, Jaewon Min, Hee-Yeon Jeon, Kwangwoo Hwang, Chuna Kim, Junho Lee, Je-Gun Joung, Woong-Yang Park, Hyunsook Lee
BRCA2 is a multifunctional tumor suppressor involved in homologous recombination (HR), mitotic checkpoint regulation, and telomere homeostasis. Absence of Brca2 in mice results in progressive shortening of telomeres and senescence, yet cells are prone to neoplastic transformation with elongated telomeres, suggesting that BRCA2 has positive and negative effects on telomere length regulation along the path to tumorigenesis. Using Caenorhabditis elegans as a model, we show here that depletion of BRC-2, an ortholog of BRCA2, paradoxically delays senescence in telomerase-deficient mutant worms...
October 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27760036/three-step-anti-ampv-iga-expression-profile-evaluation-in-turkeys-of-different-immunological-status-after-trt-vaccination
#11
M Śmiałek, B Tykałowski, D Pestka, J Welenc, T Stenzel, A Koncicki
Maternally derived antibodies (MDA) don not protect turkeys against rhinotracheitis (TRT) but high MDA influences upper respiratory tract (URT) immunity stimulation after avian Metapneumovirus (aMPV) vaccination. Humoral immunity can not be considered as an indicator of protection against TRT, but specific antibodies inhibit aMPV replication and alleviate the course of TRT. Scarce reports indicate the role of IgA in protection against TRT. The aim of our study was to investigate the impact of MDA on stimulation, antigen specificity acquisition of B lymphocytes, and the production of specific IgA after TRT vaccination of turkeys...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27747011/treatment-outcomes-of-patients-with-small-cell-lung-cancer-without-prophylactic-cranial-irradiation
#12
Masakuni Sakaguchi, Toshiya Maebayashi, Takuya Aizawa, Naoya Ishibashi, Tsutomu Saito
BACKGROUND: Prophylactic cranial irradiation (PCI) is indicated for limited disease (LD) in small cell lung cancer (SCLC) patients who achieve a complete or near-complete response; however, it is sometimes not administered because of possible adverse reactions or patient refusal. Here we assessed treatment outcomes among patients with SCLC who were not treated with PCI. METHODS: The medical records of 60 patients (45 men, 15 women; mean age, 68 years; age range, 51-82 years) with SCLC were retrospectively reviewed...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27713795/a-survey-of-canadian-urologists-opinions-and-prescribing-patterns-of-testosterone-replacement-therapy-in-men-on-active-surveillance-for-low-risk-prostate-cancer
#13
Adam C Millar, Dean S Elterman, Larry Goldenberg, Brandon Van Asseldonk, Ashley Curtis, Keith Jarvi
INTRODUCTION: Attitudes regarding the safety of testosterone replacement therapy (TRT) in hypogonadal men with prostate cancer (PCa) have changed over the past few years with the emergence of case studies suggesting a low risk of cancer progression and a better understanding of the interaction of different levels of androgen with prostate cellular metabolism. This new view has the potential to change clinical practice. METHODS: Active members of the Canadian Urological Association were surveyed about their opinions on the safety of TRT in men with low-risk PCa, as well as their current prescribing habits...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27707441/effect-of-manual-editing-of-total-recording-time-implications-for-home-sleep-testing
#14
Ying Y Zhao, Jia Weng, Daniel R Mobley, Rui Wang, Younghoon Kwon, Phyllis C Zee, Pamela L Lutsey, Susan Redline
STUDY OBJECTIVES: Type 3 home sleep apnea tests may underestimate the apnea-hypopnea index (AHI) due to overestimation of total sleep time (TST). We aimed to evaluate the effect of manual editing of the total recording time (TRT) on the TST and AHI. METHODS: Thirty 15-channel in-home polysomnography studies (AHI 0 to 30 events/h) scored using American Academy of Sleep Medicine criteria were rescored by two blinded polysomnologists after data from electroencephalogram, electrooculogram, and electromyogram were masked...
September 29, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27667131/trt-a-vertebrate-and-protozoan-tc1-like-transposon-current-activity-and-horizontal-transfer
#15
Hua-Hao Zhang, Guo-Yin Li, Xiao-Min Xiong, Min-Jin Han, Xiao-Gu Zhang, Fang-Yin Dai
We report a Danio rerio transposon named DrTRT, for D. rerio Transposon Related to Tc1 The complete sequence of the DrTRT transposon is 1,563 base pairs (bp) in length, and its transposase putatively encodes a 338-amino acid protein that harbors a DD37E motif in its catalytic domain. We present evidence based on searches of publicly available genomes that TRT elements commonly occur in vertebrates and protozoa. Phylogenetic and functional domain comparisons confirm that TRT constitutes a new subfamily within the Tc1 family...
October 5, 2016: Genome Biology and Evolution
https://www.readbyqxmd.com/read/27665357/prostate-magnetic-resonance-imaging-findings-in-patients-treated-for-testosterone-deficiency-while-on-active-surveillance-for-low-risk-prostate-cancer
#16
Takeshi Hashimoto, Krishnan Rahul, Toshikazu Takeda, Nicole Benfante, John P Mulhall, Hedvig Hricak, James A Eastham, Hebert Alberto Vargas
OBJECTIVE: To investigate the multiparametric prostate magnetic resonance imaging (mpMRI) findings in patients treated with testosterone replacement therapy (TRT) while on active surveillance for low-risk prostate cancer. METHODS: We retrospectively reviewed 12 patients who underwent mpMRI before and after TRT while on active surveillance. Changes in serum testosterone level, prostate-specific antigen (PSA), prostate biopsy findings, prostate volume, and Prostate Imaging Reporting and Data System Version 2 (PI-RADSv2) score before and after TRT were summarized...
December 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27660142/parametric-methods-for-dynamic-11c-phenytoin-pet-studies
#17
Mohd Syahir Mansor, Maqsood Yaqub, Ronald Boellaard, Femke E Froklage, Anke de Vries, Esther Dm Bakker, Rob A Voskuyl, Jonas Eriksson, Lothar A Schwarte, Joost Verbeek, Albert D Windhorst, Aadrian Lammertsma
PURPOSE: In this study the performance of various methods for generating quantitative parametric images of dynamic (11)C-phenytoin PET studies will be evaluated. METHODS: Double baseline 60 min dynamic (11)C-phenytoin PET studies, including online arterial sampling, were acquired for 6 healthy subjects. Parametric images were generated using Logan plot analysis, a basis function method (BFM) and spectral analysis (SA). Parametric distribution volume (VT) and influx rate (K1) were compared to those obtained from non-linear regression (NLR) analysis of time activity curves...
September 22, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27639459/is-progesterone-the-key-regulatory-factor-behind-ovulation-rate-in-sheep
#18
P M Bartlewski, J Sohal, V Paravinja, T Baby, M E F Oliveira, M Murawski, T Schwarz, D A Zieba, D H Keisler
Ovarian antral follicles in the ewe grow in an orderly succession, producing 3 to 4 waves per estrous cycle. In prolific sheep, some large antral follicles from the second-to-last wave of the estrous cycle are added to the ovulatory follicles emerging just before estrus to give a higher ovulation rate; it is feasible that regression of these follicles is prevented by an increase in serum concentrations of FSH or LH pulsatility at proestrus. Prolific sheep tend to have a shorter luteal phase than nonprolific ewes and there is a great deal of evidence that luteal progesterone (P4), in addition to regulating LH release, may govern the secretion of FSH heralding the emergence of follicular waves...
January 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27593554/null-allele-mutants-of-trt-1-the-catalytic-subunit-of-telomerase-in-caenorhabditis-elegans-are-less-sensitive-to-mn-induced-toxicity-and-daergic-degeneration
#19
Omamuyovwi M Ijomone, Mahfuzur R Miah, Tanara V Peres, Polycarp U Nwoha, Michael Aschner
Exposure to manganese (Mn) represents an environmental risk factor for Parkinson's disease (PD). Recent evidence suggests that telomerase reverse transcriptase (TERT), the catalytic subunit of mammalian telomerase participates in non-telomeric functions and may play a role in cellular protection from oxidative stress and DNA damage. trt-1 is the catalytic subunit of telomerase in Caenorhabditis elegans (C. elegans). The present study investigated the relationship between trt-1 mutation and Mn-induced neurotoxicity...
September 1, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27586511/opioid-induced-androgen-deficiency-opiad-diagnosis-management-and-literature-review
#20
REVIEW
Timothy K O'Rourke, Matthew S Wosnitzer
Opioid-induced androgen deficiency (OPIAD) was initially recognized as a possible consequence of opioid use roughly four decades ago. Long-acting opioid use carries risks of addiction, tolerance, and systemic side effects including hypogonadotropic hypogonadism with consequent testosterone depletion leading to multiple central and peripheral effects. Hypogonadism is induced through direct inhibitory action of opioids on receptors within the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes as well as testosterone production within the testes...
October 2016: Current Urology Reports
keyword
keyword
57215
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"