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https://www.readbyqxmd.com/read/29774669/obstructive-sleep-apnea-and-testosterone-deficiency
#1
REVIEW
Sung Dong Kim, Kyu Sup Cho
Obstructive sleep apnea (OSA) is a common disorder characterized by intermittent hypoxia and sleep fragmentation. OSA in middle-aged men is often associated with decreased testosterone secretion, together with obesity and aging. Although OSA treatment does not reliably increase testosterone levels in most studies, OSA treatment with testosterone replacement therapy (TRT) may not only improve hypogonadism, but can also alleviate erectile/sexual dysfunction. However, because TRT may exacerbate OSA in some patients, patients should be asked about OSA symptoms before and after starting TRT...
May 16, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29767498/reagentless-detection-of-low-molecular-weight-triamterene-using-self-doped-tio2-nanotubes
#2
Felipe F Hudari, Guilherme G Bessegato, Flavio Cesar Bedatty Fernandes, Maria Valnice Boldrin Zanoni, Paulo Roberto Bueno
TiO2 nanotube electrodes were self-doped by electrochemical cathodic polarisation, presumably converting Ti4+ into Ti3+, which demonstrably increased both the conductance and capacitance of the electrodes. One-hundred-fold and two-fold concomitant increases in capacitance and conductance, respectively, were achieved in self-doped TiO2 nanotubes, in comparison to their undoped counterparts. The increase in both capacitance and conductance reveals that Ti3+ states upsurge the density of electronic states, which is ascribed to an existing relationship between conductance and capacitance for mesoscopic structures built up on macroscopic electrodes...
May 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29766354/image-based-spect-calibration-based-on-the-evaluation-of-the-fraction-of-activity-in-the-field-of-view
#3
Adrien Halty, Jean-Noël Badel, Olga Kochebina, David Sarrut
BACKGROUND: SPECT quantification is important for dosimetry in targeted radionuclide therapy (TRT) and the calibration of SPECT images is a crucial stage for image quantification. The current standardized calibration protocol (MIRD 23) uses phantom acquisitions to derive a global calibration factor in specific conditions. It thus requires specific acquisitions for every clinical protocols. We proposed an alternative and complementary image-based calibration method that allows to determine a calibration factor adapted to each patient, radionuclide, and acquisition protocol and that may also be used as an additional independent calibration...
May 16, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29762760/evaluation-of-different-dietary-alterations-in-their-ability-to-mitigate-the-incidence-and-severity-of-woody-breast-and-white-striping-in-commercial-male-broilers
#4
B C Bodle, C Alvarado, R B Shirley, Y Mercier, J T Lee
The following study was conducted to define how multiple nutritional strategies affect broiler performance, meat yield, and the presence and severity of white striping (WS) and woody breast (WB) in high-yielding broilers. Relative to a commercial set of reference broiler diets (Commercial reference diet; Trt 1) that were fed in a 4-phase program, the following nutritional strategies were investigated: increasing the ratio of digestible arginine: digestible lysine (dArg: dLys ranged from 113 to 126; Trt 2), supplementing Trt 1 with 94...
May 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29762742/effects-of-reduced-digestible-lysine-density-on-myopathies-of-the-pectoralis-major-muscles-in-broiler-chickens-at-48-and-62-days-of-age
#5
K J Meloche, B I Fancher, D A Emmerson, S F Bilgili, W A Dozier
Quantitative control of nutrient intake may decrease the incidence of wooden breast (WB) and white striping (WS) myopathies with some impairment of live performance. Two experiments (Exp) utilizing Yield Plus × Ross 708 male broilers were conducted to determine if a reduction in myopathies may be obtained through a qualitative approach by reducing digestible lysine (dLys) density. All birds received an identical starter diet until 11 d of age. In Exp 1 (63 pens; 22 birds/pen), each pen was then randomly assigned to 1 of the following 7 dietary treatments (TRT) for a 47 d production period...
May 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29761311/comparison-of-fatigue-responses-and-rapid-force-characteristics-between-explosive-and-traditional-resistance-trained-males
#6
Cameron S Mackey, Ryan M Thiele, Eric C Conchola, Jason M DeFreitas
PURPOSE: To compare maximal and rapid force characteristics, as well as fatigability, between traditional (TRT) and explosive (ERT) resistance-trained men. METHODS: Fourteen TRT (mean age = 25 years) and twelve ERT (mean age = 22 years) men performed rapid maximal contractions followed by an isokinetic fatigue protocol consisting of 50 maximal knee extension (KE) and flexions (KF) at a moderate speed (180° s- ¹). Baseline measures included: isokinetic peak torque (PT), isometric rate of torque development (RTD0-50 ), peak acceleration (ACCmax ), and peak velocity (Vmax )...
May 14, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29734846/the-efficacy-and-safety-of-short-acting-testosterone-ointment-glowmin-for-late-onset-hypogonadism-in-accordance-with-testosterone-circadian-rhythm
#7
Toshiyasu Amano, Teruaki Iwamoto, Yoshikazu Sato, Tetsuya Imao, Carolyn Earle
INTRODUCTION: It is well known that there is a reduction of circadian rhythm in blood testosterone levels with aging. Our previous report revealed that 3 mg of short-acting testosterone ointment (Glowmin: GL) elevated serum testosterone levels to within the physiological range for 4-6 h. The aim of this study was to clarify the clinical efficacy and safety of GL used topically once every morning, to enhance the circadian rhythm of testosterone, for late-onset hypogonadism (LOH). METHODS: A total of 61 LOH patients received 3 mg of GL topically once a day in the morning on scrotal skin for 24 weeks...
May 8, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29733908/the-impact-of-staging-by-positron-emission-tomography-on-overall-survival-and-progression-free-survival-in-patients-with-locally-advanced-non-small-cell-lung-cancer
#8
Everett E Vokes, Ramaswamy Govindan, Neill Iscoe, Anwar M Hossain, Belen San Antonio, Nadia Chouaki, Marianna Koczywas, Suresh Senan
OBJECTIVE: We investigated the potential impact of stage migration because of positron emission tomography (PET) scan staging on survival in the locally advanced (Stage IIIA/B) non-small cell lung cancer (NSCLC) setting. METHODS: In PROCLAIM, 598 patients with stage IIIA/B nonsquamous NSCLC (intent-to-treat [ITT] population) were randomized to either pemetrexed plus cisplatin and concurrent thoracic radiotherapy (TRT) for 3 cycles followed by 4 cycles of pemetrexed consolidation or etoposide plus cisplatin and concurrent TRT for 2 cycles followed by a consolidation platinum-based doublet regimen for up to 2 cycles...
May 4, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29727002/hormone-replacement-therapy-and-opioid-tapering-for-opioid-induced-hypogonadism-among-patients-with-chronic-noncancer-pain-a-systematic-review
#9
Mahmood AminiLari, Priya Manjoo, Samantha Craigie, Rachel Couban, Li Wang, Jason W Busse
Objective: To systematically review evidence addressing the efficacy of testosterone replacement therapy (TRT) and opioid tapering for opioid-induced hypogonadism among patients with chronic noncancer pain. Study Design: Systematic review of randomized controlled trials (RCTs) and observational studies. Methods: We searched MEDLINE, CINAHL, AMED, CENTRAL, CINAHL, DARE, EMBASE, and PsycINFO through August 2017. Eligible studies enrolled ≥10 patients with chronic noncancer pain and opioid-induced hypogonadism and reported the effect of TRT or opioid tapering on a patient-important outcome collected ≥14 days after treatment...
May 2, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29716649/preexisting-radiological-interstitial-lung-abnormalities-are-a-risk-factor-for-severe-radiation-pneumonitis-in-patients-with-small-cell-lung-cancer-after-thoracic-radiation-therapy
#10
Fangjuan Li, Ziyang Zhou, Ailu Wu, Yong Cai, Hongyu Wu, Ming Chen, Shixiong Liang
BACKGROUND: Previous studies reported that patients with preexisting radiological interstitial lung abnormalities (ILAs) were more susceptible to developing radiation pneumonitis (RP) after thoracic radiation therapy (TRT). The present study aimed to evaluate the incidence and predictors of RP after TRT in patients with small-cell lung cancer (SCLC) with or without preexisting radiological ILAs. METHODS: A total of 95 consecutive patients with SCLC between January 2015 and December 2015, who were treated with thoracic intensity-modulated radiation therapy at Shanghai Pulmonary Hospital,Tongji University School of Medicine, were analyzed...
May 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29713545/systematic-review-of-hormone-replacement-therapy-in-the-infertile-man
#11
REVIEW
Amr El Meliegy, Ahmad Motawi, Mohamed Ahmed Abd El Salam
Objectives: To highlight alternative treatment options other than exogenous testosterone administration for hypogonadal men with concomitant infertility or who wish to preserve their fertility potential, as testosterone replacement therapy (TRT) inhibits spermatogenesis, representing a problem for hypogonadal men of reproductive age. Materials and methods: We performed a comprehensive literature review for the years 1978-2017 via PubMed. Also abstracts from major urological/surgical conferences were reviewed...
March 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29708829/the-impact-of-testosterone-replacement-therapy-on-glycemic-control-vascular-function-and-components-of-the-metabolic-syndrome-in-obese-hypogonadal-men-with-type-2-diabetes
#12
Kristina Groti, Ivan Žuran, Blaž Antonič, Lidija Foršnarič, Marija Pfeifer
OBJECTIVE: This study set out to assess effects of testosterone replacement therapy (TRT) on parameters of metabolic syndrome and vascular function in obese hypogonadal males with type 2 diabetes mellitus (DM2). STUDY DESIGN: Fifty-five obese hypogonadal diabetic males on oral hypoglycemic treatment were enrolled into this one-year, double-blind, randomized, placebo-controlled clinical study. Group T (n = 28) was treated with testosterone undecanoate (1000 mg i...
April 30, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29701773/effects-of-active-dry-yeast-on-ruminal-ph-characteristics-and-energy-partitioning-of-finishing-steers-under-thermoneutral-or-heat-stressed-environment
#13
W L Crossland, A B Norris, L O Tedeschi, T R Callaway
The objective of this trial was to determine the effects of supplementing active dried yeast (ADY) in the diets of finishing steers on energy and nitrogen metabolism and ruminal pH characteristics under thermoneutral (TN) or heat-stressed (HS) conditions. Eight British-cross steers received one of two treatment (TRT) (either a control finishing diet (CON) or supplemented with 3 g/d of ADY) under one of two temperatures (TEMP: TN = 18 ± 0.55°C and 20 ± 1.2% relative humidity (RH) or HS = 35 ± 0.55°C and 42 ± 6...
April 26, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29696556/long-term-effect-of-testosterone-replacement-therapy-on-bone-in-hypogonadal-men-with-klinefelter-syndrome
#14
N Tahani, L Nieddu, G Prossomariti, M Spaziani, S Granato, F Carlomagno, A Anzuini, A Lenzi, A F Radicioni, E Romagnoli
PURPOSE: To assess different aspects of bone damage in untreated adult patients with Klinefelter Syndrome (KS) before and during testosterone replacement therapy (TRT). METHODS: Fifteen untreated hypogonadal men with KS and 26 control subjects (C) matched for age and BMI were recruited. Sex hormone levels were measured in all subjects. Lumbar spine (LS) and femoral (neck: FN and total hip: TH) bone mineral density (BMD), trabecular bone score (TBS), hip structure analysis (HSA) and fat measures (percentage of fat mass, android/gynoid ratio and visceral adipose tissue) were evaluated by DEXA...
April 25, 2018: Endocrine
https://www.readbyqxmd.com/read/29689435/exploring-radiotherapy-targeting-strategy-and-dose-a-pooled-analysis-of-cooperative-group-trials-of-combined-modality-therapy-for-stage-iii-non-small-cell-lung-cancer
#15
Steven E Schild, Wen Fan, Thomas E Stinchcombe, Everett E Vokes, Suresh S Ramalingam, Jeffrey D Bradley, Karen Kelly, Herbert H Pang, Xiaofei Wang
INTRODUCTION: Concurrent chemoradiotherapy(CRT) is standard therapy for locally-advanced non-small-cell lung cancer(LA-NSCLC)patients. This study was performed to examine thoracic radiotherapy(TRT) parameters and their impact on patient survival. METHODS: We collected Individual patient data(IPD) from 3600LA-NSCLC patients participating in 16 cooperative group trials of concurrent CRT. The primary TRT parameters examined included field design strategy(elective nodal irradiation(ENI) compared to involved field TRT(IF-TRT)), total dose, and biologically effective dose(BED)...
April 21, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29675273/assessment-of-global-and-local-alterations-in-retinal-layer-thickness-in-ins2-akita-diabetic-mice-by-spectral-domain-optical-coherence-tomography
#16
Andrew W Francis, Justin Wanek, Mahnaz Shahidi
Purpose/Aim: The Ins2 (Akita) mouse is a spontaneous diabetic mouse model with a heterozygous mutation in the insulin 2 gene that results in sustained hyperglycemia. The purpose of the study was to assess global and local retinal layer thickness alterations in Akita mice by analysis of spectral domain optical coherence tomography (SD-OCT) images. Materials and Methods: SD-OCT imaging was performed in Akita and wild-type mice at 12 and 24 weeks of age. Inner retinal thickness (IRT), outer retinal thickness (ORT), total retinal thickness (TRT), and photoreceptor outer segment length (OSL) were measured...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29674209/possible-mechanisms-underlying-fatty-liver-in-a-rat-model-of-male-hypogonadism-a-protective-role-for-testosterone
#17
Hussein F Sakr, Abdelaziz M Hussein, Elsayed A Eid, Mahmoud AlKhateeb
AIMS: To investigate the effects of testosterone (Test) deficiency and testosterone replacement therapy (TRT) on the development of non-alcoholic fatty liver disease (NAFLD) and associated peripheral insulin resistance (IR) in male rats and to illustrate the underlying mechanisms of action. MATERIALS AND METHODS: male Sprague Dawley rats were divided into 3 groups as follows: 1) sham-operated group (n=11), 2) ORCD-induced group (n=9) exposed to orchidectomy (ORCD), achieved by complete surgical removal of testicles, and 3) ORCD+ Test treated group (n=10) (11 ng/ mL Test propionate, 3x/week, S...
April 16, 2018: Steroids
https://www.readbyqxmd.com/read/29667546/seminal-supar-levels-as-marker-of-abacterial-male-accessory-gland-inflammation-in-hypogonadism
#18
Domenico Milardi, Giuseppe Grande, Chiara Autilio, Francesca Mancini, Laura De Marinis, Riccardo Marana, Cecilia Zuppi, Andrea Urbani, Alfredo Pontecorvi, Silvia Baroni
Recent evidences suggest that hypogonadism is an important risk factor for lower urinary tract symptoms and benign prostatic hyperplasia. Several papers have discussed the role of chronic inflammation in the development of BPH, which may be modulated by the hypogonadal state. Soluble urokinase-type plasminogen activator receptor (suPAR), known protein marker of systemic inflammation, can be assayed in the seminal plasma and represents a reliable and sensitive marker of inflammation for the male accessory gland inflammation (MAGI)...
April 18, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29656500/mitochondria-glycogen-and-lipid-droplets-in-skeletal-muscle-during-testosterone-treatment-and-strength-training-a-randomized-double-blinded-placebo-controlled-trial
#19
R C Jensen, L L Christensen, J Nielsen, H D Schrøder, T Kvorning, K Gejl, K Højlund, D Glintborg, M Andersen
Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double-blinded, placebo-controlled study, we investigated the effects of six-month testosterone replacement therapy (TRT) and strength training (ST) on mitochondrial, glycogen, and lipid droplet (LD) content in skeletal muscle of aging men with subnormal bioavailable testosterone (BioT) levels...
April 15, 2018: Andrology
https://www.readbyqxmd.com/read/29623698/shifting-the-paradigm-of-testosterone-replacement-therapy-in-prostate-cancer
#20
REVIEW
Michael A Bell, Jeffrey D Campbell, Gregory Joice, Nikolai A Sopko, Arthur L Burnett
Historically, testosterone and prostate cancer have been demonstrated to have a positive association leading providers to forgo testosterone replacement therapy (TRT) in men with concurrent histories of hypogonadism and prostate cancer. This paradigm has been gradually shifting with our evolving understanding of the relationship between testosterone and prostate cancer and the gaining popularity of the saturation model. Newer data suggests improved quality of life for men with hypogonadism after TRT leading to a more tempered view of the effects of this treatment and its risk in prostate cancer...
March 22, 2018: World Journal of Men's Health
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