Anara Molkenova, Hye Eun Choi, Gibum Lee, Hayeon Baek, Mina Kwon, Su Bin Lee, Jeong-Min Park, Jae-Hyuk Kim, Dong-Wook Han, Jungwon Park, Sei Kwang Hahn, Ki Su Kim
Cryotherapy leverages controlled freezing temperature interventions to engender a cascade of tumor-suppressing effects. However, its bottleneck lies in the standalone ineffectiveness. A promising strategy is using nanoparticle therapeutics to augment the efficacy of cryotherapy. Here, a cold-responsive nanoplatform composed of upconversion nanoparticles coated with silica - chlorin e6 - hyaluronic acid (UCNPs@SiO2 -Ce6-HA) is designed. This nanoplatform is employed to integrate cryotherapy with photodynamic therapy (PDT) in order to improve skin cancer treatment efficacy in a synergistic manner...
March 14, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)