keyword
https://read.qxmd.com/read/38503369/a-polyethylene-glycol-grafted-pullulan-polysaccharide-adhesive-improves-drug-loading-capacity-and-release-efficiency
#21
JOURNAL ARTICLE
Haoyuan Song, Longyi Nan, Jiaqi Wang, Yu Cai, Peng Sun, Jie Liu, Chao Liu, Liang Fang
In this study, polyethylene glycol was grafted onto pullulan polysaccharides, resulting in the development of a novel adhesive termed PLUPE, offering superior drug loading capacity and rapid release efficiency. The efficacy of PLUPE was rigorously evaluated through various tests, including the tack test, shear strength test, 180° peel strength test, and human skin adhesion test. The results demonstrated that PLUPE exhibited a static shear strength that was 4.6 to 9.3 times higher than conventional PSAs, ensuring secure adhesion for over 3 days on human skin...
March 17, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38502545/fabrication-evaluation-and-enhanced-penetration-of-vinyl-and-cellulose-engineered-transdermal-patch-of-nifedipine-using-essential-oil-as-penetration-enhancer
#22
JOURNAL ARTICLE
Stabak Das, Sudip Das, Sanjib Bahadur, Maitreyee Mukherjee, Gouranga Nandi, Sreejan Manna
The aim of this study was to develop and evaluate the transdermal patch formulations of nifedipine. The patch formulations containing nifedipine were prepared and optimized with different ratios of vinyl and cellulose-derived polymers, drug contents, and permeation enhancers. Among the various formulations, the patch formulation containing a 1:5 ratio of ethyl cellulose and polyvinyl pyrrolidone was selected for ex vivo pharmacokinetic study based on in vitro permeation studies using stratum corneum of the pig's skin...
March 19, 2024: Journal of Biomaterials Science. Polymer Edition
https://read.qxmd.com/read/38501457/preclinical-pharmacokinetic-investigation-of-the-bioavailability-and-skin-distribution-of-hy-072808-ointment-a-novel-drug-candidate-for-the-treatment-of-atopic-dermatitis-in-minipigs-by-a-newly-lc-ms-ms-method
#23
JOURNAL ARTICLE
Li Shao, Jiajia Mo, Qinlong Xu, Guangwei He, Chunyu Xing, Zhaoxing Chu
1. HY-072808 is a novel phosphodiesterase 4 inhibitor clinically used for topical atopic dermatitis treatment. Cytochrome P450 enzymes are involved in transforming it into major metabolite ZZ-24. An efficient UPLC-MS/MS method was established to detect HY-072808 and ZZ-24 in plasma and skin tissues of minipigs.2. One-step protein precipitation was performed with acetonitrile. Subsequently, elution was served with a methanol and water gradient containing 0.1% formic acid for 3.5 min. The plasma and skin tissue concentrations of HY-072808 and ZZ-24 showed good linearity from 0...
March 19, 2024: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://read.qxmd.com/read/38498325/reproductive-planning-short-acting-reversible-contraceptives
#24
JOURNAL ARTICLE
Megan L Wilson, Emily M Godfrey, Samantha Glass, Ying Zhang
Short-acting reversible contraceptives (SARCs) are prescribed routinely by primary care clinicians. SARCs are among the most commonly prescribed contraceptive methods and include combined hormonal oral contraceptive pills, the combined hormonal transdermal patch, the combined hormonal vaginal ring, progestin-only pills, and the 3-month depot medroxyprogesterone acetate injection. To ensure safe prescribing and reduce barriers to receiving SARC methods, family physicians should be familiar with two evidence-based national contraceptive guidelines, the U...
March 2024: FP Essentials
https://read.qxmd.com/read/38497274/development-of-a-novel-human-stratum-corneum-mimetic-phospholipid-vesicle-based-permeation-assay-models-for-in-vitro-permeation-studies
#25
JOURNAL ARTICLE
Yuerong Qian, Xuchao Wei, Yiwei Wang, Shaoping Yin, Jun Chen, Jie Dong
Objectives: Development and evaluation of a novel human stratum corneum (SC) mimetic phospholipid vesicle-based permeation assay (PVPASC ) model for in vitro permeation studies. Significance: Due Owing to the increasing restrictions ion the use of human and animal skins, artificial skin models have attracted lots of substantial interest in pharmaceuticals and cosmetic industrials. In this study, a modified PVPASC model containing both SC lipids and proteins was developed. Methods: The PVPASC model was optimized by altering changing the lipid composition and adding keratin in the formulation of large liposomes...
March 18, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38494171/multiple-widespread-fixed-drug-eruption-caused-by-in-a-transdermal-therapeutic-system
#26
Laura Taboada Paz, Pilar Iriarte Soter, Elena Vicente Basanta, Silvia Ojea Varona, Adrián Santiago López Caamaño, Laura López Solache, Benigno Monteagudo Sanchez
No abstract text is available yet for this article.
March 17, 2024: Contact Dermatitis
https://read.qxmd.com/read/38489702/effect-of-co2-fractional-laser-combined-with-recombinant-human-epidermal-growth-factor-gel-on-skin-barrier
#27
JOURNAL ARTICLE
Hua Wang, Fan Yang, Hui Wang, Tao Qin, Jia He, Chan Zhao
To evaluate the impact of CO2 fractional laser combined with recombinant human epidermal growth factor (rhEGF) gel on skin barrier in acne scar patients. In a retrospective analysis, we examined 105 acne scar patients admitted between July 2018 and August 2021. Of these, 51 received only CO2 fractional laser (control group), while 54 underwent a combination of CO2 fractional laser and rhEGF gel (observation group). We assessed treatment efficacy, symptom relief, skin barrier parameters, pre- and posttreatment inflammatory factors, adverse reactions, posttreatment quality of life, and patient satisfaction...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38484176/alpha-alert-utilization-of-transdermal-clonidine-for-refractory-agitation
#28
JOURNAL ARTICLE
Samantha Grable, Gary Houchard, Zach Rossfeld
Alpha-2 agonists are under-recognized for their class effects yet offer potential benefit in specialty palliative care via decreasing sympathetic output, inducing sedation, and modulating pain. Especially in clinical contexts where agitation predominates and patients are intolerant of oral medication route, transdermal medication delivery is advantageous. We report a case of agitated behaviors in setting of mixed Alzheimer/vascular-type dementia limiting hospital discharge to nursing facility that were ameliorated with transdermal clonidine...
March 14, 2024: Journal of Pain & Palliative Care Pharmacotherapy
https://read.qxmd.com/read/38482992/cold-responsive-hyaluronated-upconversion-nanoplatform-for-transdermal-cryo-photodynamic-cancer-therapy
#29
JOURNAL ARTICLE
Anara Molkenova, Hye Eun Choi, Gibum Lee, Hayeon Baek, Mina Kwon, Su Bin Lee, Jeong-Min Park, Jae-Hyuk Kim, Dong-Wook Han, Jungwon Park, Sei Kwang Hahn, Ki Su Kim
Cryotherapy leverages controlled freezing temperature interventions to engender a cascade of tumor-suppressing effects. However, its bottleneck lies in the standalone ineffectiveness. A promising strategy is using nanoparticle therapeutics to augment the efficacy of cryotherapy. Here, a cold-responsive nanoplatform composed of upconversion nanoparticles coated with silica - chlorin e6 - hyaluronic acid (UCNPs@SiO2 -Ce6-HA) is designed. This nanoplatform is employed to integrate cryotherapy with photodynamic therapy (PDT) in order to improve skin cancer treatment efficacy in a synergistic manner...
March 14, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38482628/deformable-vesicles-with-edge-activators-for-the-transdermal-delivery-of-non-psychoactive-cannabinoids
#30
JOURNAL ARTICLE
Elisa Vettorato, Marisa Fiordelisi, Silvia Ferro, Desirè Zanin, Erica Franceschinis, Giovanni Marzaro, Nicola Realdon
BACKGROUND: Transdermal delivery of highly lipophilic molecules is challenging due to the strong barrier function of the skin. Vesicles with penetration enhancers are safe and efficient systems that could improve the transdermal delivery of non-psychoactive cannabinoids such as cannabidiol and desoxy-cannabidiol. In the last decades, research interest in desoxy-cannabidiol as a potent drug with anti-nociceptive properties has risen. Still, its scarce market availability poses a limit for both research and clinical applications...
March 12, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38482519/co-delivery-of-aceclofenac-and-methotrexate-nanoparticles-presents-an-effective-treatment-for-rheumatoid-arthritis
#31
JOURNAL ARTICLE
Sushmita Negi, Nikunj Tandel, Neeraj K Garg, Prakriti Sharma, Rajinder Kumar, Praveen Sharma, Reetesh Kumar, Sheetal Saini, Aman Sharma, Rajeev K Tyagi
BACKGROUND: Rheumatoid arthritis (RA) is a common acute inflammatory autoimmune connective tissue arthropathy. The genetic studies, tissue analyses, experimental animal models, and clinical investigations have confirmed that stromal tissue damage and pathology driven by RA mounts the chronic inflammation and dysregulated immune events. METHODS: We developed methotrexate (MTX)-loaded lipid-polymer hybrid nanoparticles (MTX-LPHNPs) and aceclofenac (ACE)-loaded nanostructured lipid carriers (ACE-NLCs) for the efficient co-delivery of MTX and ACE via intravenous and transdermal routes, respectively...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38479485/comparative-evaluation-of-physical-and-chemical-enhancement-techniques-for-transdermal-delivery-of-linagliptin
#32
JOURNAL ARTICLE
Tanvi Karve, Ajay K Banga
Linagliptin is a dipeptidyl peptidase-4 inhibitor used for the management of type-2 diabetes. US FDA-approved products are available exclusively as oral tablets. The inherent drawbacks of the oral administration route necessitate exploring delivery strategies via other routes. In this study, we investigated the feasibility of transdermal administration of linagliptin through various approaches. We compared chemical penetration enhancers (oleic acid, oleyl alcohol, and isopropyl myristate) and physical enhancement techniques (iontophoresis, sonophoresis, microneedles, laser, and microdermabrasion) to understand their potential to improve transdermal delivery of linagliptin...
March 11, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38477350/novel-smartreservoirs-for-hydrogel-forming-microneedles-to-improve-the-transdermal-delivery-of-rifampicin
#33
JOURNAL ARTICLE
Abraham M Abraham, Qonita Kurnia Anjani, Masoud Adhami, Aaron R J Hutton, Eneko Larrañeta, Ryan F Donnelly
Hydrogel-forming microneedles (HF-MNs) are composed of unique cross-linked polymers that are devoid of the active pharmaceutical ingredient (API) within the microneedle array. Instead, the API is housed in a reservoir affixed on the top of the baseplate of the HF-MNs. To date, various types of drug-reservoirs and multiple solubility-enhancing approaches have been employed to deliver hydrophobic molecules combined with HF-MNs. These strategies are not without drawbacks, as they require multiple manufacturing steps, from solubility enhancement to reservoir production...
March 13, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38476651/commercial-hydrogel-product-for-drug-delivery-based-on-route-of-administration
#34
REVIEW
Amin Raeisi, Fatemeh Farjadian
Hydrogels are hydrophilic, three-dimensional, cross-linked polymers that absorb significant amounts of biological fluids or water. Hydrogels possess several favorable properties, including flexibility, stimulus-responsiveness, versatility, and structural composition. They can be categorized according to their sources, synthesis route, response to stimulus, and application. Controlling the cross-link density matrix and the hydrogels' attraction to water while they're swelling makes it easy to change their porous structure, which makes them ideal for drug delivery...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38471772/design-of-a-novel-delivery-efficiency-feedback-system-for-biphasic-dissolving-microarray-patches-based-on-poly-lactic-acid-and-moisture-indicating-silica
#35
JOURNAL ARTICLE
Huanhuan Li, Qonita Kurnia Anjani, Aaron R J Hutton, Juan Luis Paris, Natalia Moreno-Castellanos, Achmad Himawan, Eneko Larrañeta, Ryan F Donnelly
Dissolving microarray patches (DMAPs) represent an innovative approach to minimally invasive transdermal drug delivery, demonstrating efficacy in delivering both small and large therapeutic molecules. However, concerns raised in end-user surveys have hindered their commercialization efforts. One prevalent issue highlighted in these surveys is the lack of clear indicators for successful patch insertion and removal time. To address this challenge, we devised a colour-change-based feedback system that confirms insertion and dissolution of DMAPs, aiming to mitigate the aforementioned problems...
March 12, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38469958/spray-induced-and-nanocarrier-delivered-gene-silencing-system-targeting-juvenile-hormone-receptor-components-potential-application-as-fertility-inhibitors-for-adelphocoris-suturalis-management
#36
JOURNAL ARTICLE
Wanying Zheng, Xiaona Xu, Xingxing Huang, Jie Peng, Weihua Ma, J Joe Hull, Hongxia Hua, Lizhen Chen
BACKGROUND: Adelphocoris suturalis is a destructive pest that attacks >270 plants, including cotton, maize, soybean, and fruit trees. A. suturalis can cause tremendous crop losses when the density exceeds economic thresholds, but because it can be both phytophagous and zoophytophagous it can serve as a natural enemy of other pests when the density is below the economic threshold. Effective control of its population is beneficial for maximizing yield and profits. RNA interference (RNAi) has potential to be a viable alternative to conventional pesticide-based pest management, but the lack of efficient dsRNA delivery systems and candidate genes are currently limiting factors for field applications...
March 12, 2024: Pest Management Science
https://read.qxmd.com/read/38468261/microneedles-loaded-with-cerium-manganese-oxide-nanoparticles-for-targeting-macrophages-in-the-treatment-of-rheumatoid-arthritis
#37
JOURNAL ARTICLE
Tian Xia, Yuting Zhu, Kaiqiang Li, Ke Hao, Yingqian Chai, Hongyi Jiang, Chao Lou, Jiachen Yu, Wei Yang, Jilong Wang, Junjie Deng, Zhen Wang
BACKGROUND: Rheumatoid arthritis (RA) is a prevalent inflammatory autoimmune disease characterised by persistent inflammation and joint damage with elevated levels of reactive oxygen species (ROS). Current treatment modalities for RA have significant limitations, including poor bioavailability, severe side effects, and inadequate targeting of inflamed joints. Herein, we synthesised cerium/manganese oxide nanoparticles (NPs) as efficient drug carriers with antioxidant and catalytic-like functions that can eliminate ROS to facilitate the polarization of macrophages phenotype from M1 to M2 and alleviate inflammation...
March 11, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38467334/cyclodextrin-microneedles-for-the-delivery-of-a-nanoparticle-based-peptide-antigen-vaccine
#38
JOURNAL ARTICLE
Silvana Geisshüsler, Frida Nilsson, Nicole Ziak, Zuzanna Kotkowska, Marta Paolucci, Marina Green Buzhor, Nicole Zoratto, Pål Johansen, Jean-Christophe Leroux
In recent years, microneedles (MNs) have gained considerable interest in drug formulation due to their non-invasive and patient-friendly nature. Dissolving MNs have emerged as a promising approach to enhance drug delivery across the skin in a painless manner without generating sharp waste and providing the possibility for self-administration. Cyclodextrins, a group of cyclic oligosaccharides, are well-established in pharmaceutical products due to their safety and unique ability to form inclusion complexes with various drug molecules...
March 9, 2024: European Journal of Pharmaceutics and Biopharmaceutics
https://read.qxmd.com/read/38466676/chromolaena-odorata-layered-nitrile-rubber-polymer-transdermal-patch-enhanced-wound-healing-in-vivo
#39
JOURNAL ARTICLE
Mazlyzam Abdul Latif, Asrul Mustafa, Lee Chee Keong, Asmah Hamid
The objective is to investigate the healing efficacy of a Chromolaena odorata layered-nitrile rubber transdermal patch on excision wound healing in rats. Wounds were induced in Sprague-Dawley rats and were later treated as follows: wound A, the negative control, received no treatment (NC); wound B, the negative control with an empty nitrile rubber patch (NC-ERP); wound C, treated with a C. odorata layered-nitrile rubber patch (CO-NRP); and wound D, the positive control with Solcoseryl gel with a nitrile rubber patch (PC-SG-NRP)...
2024: PloS One
https://read.qxmd.com/read/38466016/ionic-liquid-mediated-ethosome-for-transdermal-delivery-of-insulin
#40
JOURNAL ARTICLE
Fahmida Habib Nabila, Rashedul Islam, Islam Md Shimul, Muhammad Moniruzzaman, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto
Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl- sn-glycero -3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability.
March 11, 2024: Chemical Communications: Chem Comm
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