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https://www.readbyqxmd.com/read/28346390/the-effect-and-mechanism-of-transdermal-penetration-enhancement-of-fu-s-cupping-therapy-new-physical-penetration-technology-for-transdermal-administration-with-traditional-chinese-medicine-tcm-characteristics
#1
Wei-Jie Xie, Yong-Ping Zhang, Jian Xu, Xiao-Bo Sun, Fang-Fang Yang
BACKGROUND: In this paper, a new type of physical penetration technology for transdermal administration with traditional Chinese medicine (TCM) characteristics is presented. Fu's cupping therapy (FCT), was established and studied using in vitro and in vivo experiments and the penetration effect and mechanism of FCT physical penetration technology was preliminarily discussed. METHODS: With 1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-ylacetic acid (indomethacin, IM) as a model drug, the establishment of high, medium, and low references was completed for the chemical permeation system via in vitro transdermal tests...
March 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28345030/wearable-disposable-sweat-based-glucose-monitoring-device-with-multistage-transdermal-drug-delivery-module
#2
Hyunjae Lee, Changyeong Song, Yong Seok Hong, Min Sung Kim, Hye Rim Cho, Taegyu Kang, Kwangsoo Shin, Seung Hong Choi, Taeghwan Hyeon, Dae-Hyeong Kim
Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28344656/levodopa-carbidopa-enteral-suspension-in-advanced-parkinson-s-disease-clinical-evidence-and-experience
#3
REVIEW
Johan Virhammar, Dag Nyholm
The duration of action of oral levodopa becomes shorter as Parkinson's disease (PD) progresses. Patients with advanced PD may develop potentially disabling motor fluctuations and abnormal involuntary movement (dyskinesia), which cannot be managed with optimized oral or transdermal PD medications. The progressively worsening symptoms can have a substantial impact on the patient quality of life (QoL). Levodopa-carbidopa intestinal gel (LCIG) is delivered continuously via a percutaneous endoscopic gastrostomy with a jejunal extension (PEG-J)...
March 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28344015/transdermal-delivery-of-atorvastatin-calcium-from-novel-nanovesicular-systems-using-polyethylene-glycol-fatty-acid-esters-ameliorated-effect-without-liver-toxicity-in-poloxamer-407-induced-hyperlipidemic-rats
#4
Mohamed O Mahmoud, Heba M Aboud, Amira H Hassan, Adel A Ali, Thomas P Johnston
CONTEXT: Atorvastatin calcium (ATV), a cholesterol-lowering agent, suffers from poor systemic availability (14%) after oral administration in addition to other side effects on the gastrointestinal tract, liver and muscle. OBJECTIVE: The goal of the present investigation was to improve ATV bioavailability and overcome complications attendant with peroral administration by developing a new nanovesicular system encapsulating ATV for its delivery via the transdermal route...
March 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28344014/fabrication-of-coated-polymer-microneedles-for-transdermal-drug-delivery
#5
Yang Chen, Bo Zhi Chen, Qi Lei Wang, Xuan Jin, Xin Dong Guo
As an alternative to hypodermic needles, coated polymer microneedles (MNs) are able to deliver drugs to subcutaneous tissues after being inserted into the skin. The dip-coating process is a versatile, rapid fabricating method that can form coated MNs in a short time. However, it is still a challenge to fabricate coated MNs with homogeneous and precise drug doses in the dip-coating process. In this study, to fabricate coated polymer microneedles with controlled drug loading, an adjustable apparatus that can be lifted and lowered was designed to immerse a polylactic acid (PLA) MN patch in the coating solutions...
March 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28344013/a-self-adherent-bullet-shaped-microneedle-patch-for-controlled-transdermal-delivery-of-insulin
#6
Keum-Yong Seong, Min-Soo Seo, Dae Yeon Hwang, Eoin D O'Cearbhaill, Seamus Sreenan, Jeffrey M Karp, Seung Yun Yang
Proteins are important biologic therapeutics used for the treatment of various diseases. However, owing to low bioavailability and poor skin permeability, transdermal delivery of protein therapeutics poses a significant challenge. Here, we present a new approach for transdermal protein delivery using bullet-shaped double-layered microneedle (MN) arrays with water-swellable tips. This design enabled the MNs to mechanically interlock with soft tissues by selective distal swelling after skin insertion. Additionally, prolonged release of loaded proteins by passive diffusion through the swollen tips was obtained...
March 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28343991/ftransdermal-iontophoretic-delivery-of-lysine-proline-valine-kpv-peptide-across-microporated-human-skin
#7
Kasturi Pawar, Chandra S Kolli, Vijaya K Rangari, R Jayachandra Babu
Lysine-Proline-Valine (KPV) is a C-terminal peptide fragment of α-MSH with potent anti-inflammatory properties. Current study investigates various transdermal enhancement strategies such as iontophoresis (ITP), microneedles (MN) and their combination (ITP+MN) on KPV delivery across dermatomed human skin. KPV attains a positive charge at pH below 7.0, thus anodal ITP was employed. The influence of current strength, KPV concentration, and duration of current application on the KPV delivery was investigated. At defined ITP parameters, the influence of MN on KPV delivery (ITP+MN) across skin was also determined...
March 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28343933/testing-the-immunocompetence-handicap-hypothesis-testosterone-manipulation-does-not-affect-wound-healing-in-male-salamanders
#8
Jessica R Thomas, Sarah K Woodley
In vertebrates, a bidirectional relationship exists between the immune system and the hypothalamic-pituitary-gonadal axis. In addition, sexual dimorphism in immunity has been documented in many vertebrates as well as some invertebrates, and males are generally less immunocompetent than their female counterparts. A possible explanation for this is described by the immunocompetence handicap hypothesis (ICHH), which proposes that elevated testosterone (T) levels direct resources towards the promotion of secondary sexual characteristics at a cost to immune function...
March 23, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28343798/assessment-of-a-novel-transdermal-selective-%C3%AE-1-blocker-the-bisoprolol-patch-for-treating-frequent-premature-ventricular-contractions-in-patients-without-structural-heart-disease
#9
Masaya Shinohara, Tadashi Fujino, Hideki Koike, Ken Kitahara, Toshio Kinoshita, Hitomi Yuzawa, Takeya Suzuki, Shunji Fukunaga, Kenzaburo Kobayashi, Jiro Aoki, Kengo Tanabe, Takanori Ikeda
BACKGROUND: The autonomic nervous system involves the genesis of premature ventricular contractions (PVCs). Previous studies demonstrated that heart rate (HR) dependency of idiopathic PVCs has different autonomic mechanisms. Recently, the bisoprolol patch, a novel transdermal β1-blocker formulation containing bisoprolol, became clinically available. We examined the efficacy of the bisoprolol patch for treating frequent PVCs in patients without structural heart disease (SHD) regarding the HR dependency of PVCs...
March 23, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28343120/nanoemulgel-using-a-bicephalous-heterolipid-as-a-novel-approach-to-enhance-transdermal-permeation-of-tenofovir
#10
Sanjeev Rambharose, Rahul S Kalhapure, Thirumala Govender
Improvements in permeation enhancement strategies, such as nanoemulsions (NEs) and nanoemulgels (NEGs), have led to a renewed interest in transdermal drug delivery (TDD). This study aimed to investigate the potential of LLA1E, a novel dendritic permeation enhancer, as an oily phase in the development of a NEG for the TDD of tenofovir (TNF). TNF loaded NEs (TNEs) were prepared and analysed for mean globule diameter (MGD), polydispersity index (PDI), zeta potential (ZP) and morphology. NEGs of the TNEs (TNEGs) were prepared and evaluated for ex vivo transdermal permeation efficacy...
March 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28342306/rotigotine-may-control-drooling-in-patients-with-parkinson-s-disease-preliminary-findings
#11
Tommaso Schirinzi, Paola Imbriani, Alessio D'Elia, Giulia Di Lazzaro, Nicola Biagio Mercuri, Antonio Pisani
OBJECTIVE: To evaluate the efficacy of rotigotine in controlling the drooling of Parkinson's Disease (PD) patients. PATIENTS AND METHODS: We assessed 7 PD patients (Hoehn and Yahr scale >2.5) with three different clinical scores (Drooling Severity and Frequency Scale - DSFS, Drooling Rating Scale - DRS and Sialorrhea Clinical Scale for PD - SCS) before and after 4 weeks of therapy. Statistical differences were analyzed with Wilcoxon signed-rank test. RESULTS: We observed that rotigotine significantly improves drooling as measured by the lowering of the three scores (p<0...
March 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28341597/effect-of-isopropyl-myristate-on-transdermal-permeation-of-testosterone-from-carbopol-gel
#12
Ahmed S Zidan, Nahid Kamal, Alaadin Alayoubi, Mark Seggel, Sarah Ibrahim, Ziyaur Rahman, Celia Cruz, Muhammad Ashraf
The objective of the current study was to investigate the effect of isopropyl myristate (IPM) on the in vitro permeation of Testosterone through human cadaver skin from carbopol- gels. Six Testosterone gel formulations were prepared employing different IPM contents of 0, 0.4, 0.7, 1, 2 and 3%. The gels were characterized for drug permeation, matrix morphology, pH, kinetics of ethanol evaporation and viscosity. Mass balance studies were performed to estimate testosterone distribution among the compartments of diffusion cells...
March 21, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28338352/formulation-challenges-for-21st-century-topical-and-transdermal-delivery-systems
#13
Mayank Singhal, Maria Lapteva, Yogeshvar N Kalia
No abstract text is available yet for this article.
March 24, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28338008/noninvasive-measurement-of-transdermal-drug-delivery-by-impedance-spectroscopy
#14
Pasquale Arpaia, Umberto Cesaro, Nicola Moccaldi
The effectiveness in transdermal delivery of skin permeation strategies (e.g., chemical enhancers, vesicular carrier systems, sonophoresis, iontophoresis, and electroporation) is poorly investigated outside of laboratory. In therapeutic application, the lack of recognized techniques for measuring the actually-released drug affects the scientific concept itself of dosage for topically- and transdermally-delivered drugs. Here we prove the suitability of impedance measurement for assessing the amount of drug penetrated into the skin after transdermal delivery...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337858/transdermal-protein-delivery-using-choline-and-geranate-cage-deep-eutectic-solvent
#15
Amrita Banerjee, Kelly Ibsen, Yasunori Iwao, Michael Zakrewsky, Samir Mitragotri
Transdermal delivery of peptides and other biological macromolecules is limited due to skin's inherent low permeability. Here, the authors report the use of a deep eutectic solvent, choline and geranate (CAGE), to enhance topical delivery of proteins such as bovine serum albumin (BSA, molecular weight: ≈66 kDa), ovalbumin (OVA, molecular weight: ≈45 kDa) and insulin (INS, molecular weight: 5.8 kDa). CAGE enhances permeation of BSA, OVA, and insulin into porcine skin ex vivo, penetrating deep into the epidermis and dermis...
March 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28337672/fentanyl-formulations-in-the-management-of-pain-an-update
#16
REVIEW
Stephan A Schug, Sonya Ting
Fentanyl is a synthetic, highly selective opioid with many desirable physicochemical properties, including a high lipophilicity and predictable pharmacokinetics. These properties have an established record in the management of pain in a variety of settings, particularly acute pain and breakthrough cancer pain. Fentanyl was initially developed for parenteral use; however, this is invasive and impractical in the outpatient setting. Unfortunately, the high first-pass metabolism of fentanyl makes oral formulations unfeasible...
March 23, 2017: Drugs
https://www.readbyqxmd.com/read/28336458/nile-red-nanosuspensions-as-investigative-model-to-study-the-follicular-targeting-of-drug-nanocrystals
#17
Francesco Corrias, Michele Schlich, Chiara Sinico, Rosa Pireddu, Donatella Valenti, Anna Maria Fadda, Salvatore Marceddu, Francesco Lai
The strategy of formulating poorly soluble actives as nanosuspension has been explored by more than a thousand research papers, with some medicinal products for oral and intravenous use having reached the market or advanced clinical trials. Interestingly, there is a limited number of reports of nanosuspensions formulated for dermal and transdermal drug delivery. In the present work, a nanocrystals suspension of the fluorescent, water-insoluble dye Nile Red, is prepared through a media milling technique and exploited to characterize the fate of the nanosuspended drug when applied on the skin...
March 20, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28334510/pharmacokinetics-of-testosterone-cream-applied-to-scrotal-skin
#18
R Iyer, S F Mok, S Savkovic, L Turner, G Fraser, R Desai, V Jayadev, A J Conway, D J Handelsman
Scrotal skin is thin and has high steroid permeability, but the pharmacokinetics of testosterone via the scrotal skin route has not been studied in detail. The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single-center, three-phase cross-over pharmacokinetic study of three single doses (12.5, 25, 50 mg) of testosterone cream administered in random sequence on different days with at least 2 days between doses to healthy eugonadal volunteers with endogenous testosterone suppressed by administration of nandrolone decanoate...
March 23, 2017: Andrology
https://www.readbyqxmd.com/read/28333671/compounding-transdermal-medication-for-feline-patients
#19
Lauren R Eichstadt
Transdermal medications are a desirable route of administration for feline patients. However, before compounding, pharmacists and veterinarians should critically evaluate if the medication is appropriate for administration via the transdermal route. This article discusses points to consider regarding transdermal therapy. Tables summarizing the current literature and medications that should never be used transdermally are included.
July 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28333667/effect-of-penetration-enhancers-on-the-percutaneous-delivery-of-pain-management-actives
#20
John Trimble, Bob Light
Transdermal compositions for pain management are comprised of nonsteroidal anti-inflammatory drugs, opioid drugs, and adjuvant drugs acting on: voltage-gated channels, gamma-aminobutyric acid receptors, acute musculoskeletal pain, and as an antidepressant. In this work, baclofen, bupivacaine, cyclobenzaprine, diclofenac, gabapentin, ibuprofen, ketamine, and pentoxifylline were loaded in transdermal compositions, prepared using a mixture of lipids (isopropyl palmitate and mineral oil) and one of two selected penetration enhancer mixtures: alkyl dimethicone, phenyl trimethicone, and polyoxyethylene sorbitan monostearate; and cetostearyl polyoxyethylene ether and ethylene oxide/propylene oxide copolymer...
May 2016: International Journal of Pharmaceutical Compounding
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