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https://www.readbyqxmd.com/read/29909597/recent-advances-and-future-of-gene-therapy-for-bone-regeneration
#1
REVIEW
Galina Shapiro, Raphael Lieber, Dan Gazit, Gadi Pelled
PURPOSE OF REVIEW: The purpose of this review is to discuss the recent advances in gene therapy as a treatment for bone regeneration. While most fractures heal spontaneously, patients who present with fracture nonunion suffer from prolonged pain, disability, and often require additional operations to regain musculoskeletal function. RECENT FINDINGS: In the last few years, BMP gene delivery by means of electroporation and sonoporation resulted in repair of nonunion bone defects in mice, rats, and minipigs...
June 16, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29909584/comparison-of-clinical-results-between-novel-percutaneous-pedicle-screw-and-traditional-open-pedicle-screw-fixation-for-thoracolumbar-fractures-without-neurological-deficit
#2
Ming Yang, Qinpeng Zhao, Dingjun Hao, Zhen Chang, Shichang Liu, Xinhua Yin
OBJECTIVES: To compare the efficacy and safety of novel percutaneous minimally invasive pedicle screw fixation and traditional open surgery for thoracolumbar fractures without neurological deficit. METHODS: Sixty adult patients with single thoracolumbar fracture between June 2014 and June 2016 were recruited in this study, randomly divided into open fixation group (group A) or minimally invasive percutaneous fixation group (group B). Clinical and surgical evaluation including surgery time, blood losses, radiation times, hospital stay, and complication were performed...
June 16, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29909254/guidelines-for-the-cleaning-and-sterilization-of-intraocular-surgical-instruments
#3
REVIEW
David F Chang, Nick Mamalis
These Guidelines for the Cleaning and Sterilization of Intraocular Surgical Instruments were written by the Ophthalmic Instrument Cleaning and Sterilization (OICS) Task Force, comprised of representatives of the American Society of Cataract and Refractive Surgery, the American Academy of Ophthalmology, and the Outpatient Ophthalmic Surgery Society. These consensus subspecialty guidelines include evidence-based recommendations regarding issues that may be unique to the cleaning and sterilization of intraocular instrumentation...
June 13, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29909253/long-term-safety-and-efficacy-of-single-port-pars-plana-anterior-vitrectomy-with-limbal-infusion-during-anterior-segment-surgery
#4
Ivey L Thornton, Brian K McMains, Michael E Snyder
PURPOSE: To report the safety and efficacy of single-port pars plana anterior vitrectomy. SETTING: Cincinnati Eye Institute, Cincinnati, Ohio, USA. DESIGN: Retrospective case series. METHODS: Eyes that had anterior vitrectomy from September 2010 to June 2016 were electronically identified. Charts were reviewed for demographics, history of ocular trauma, underlying ocular or systemic comorbidity, surgical indications, outcomes, and postoperative complications...
June 13, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29909089/safety-of-laparoscopic-surgery-for-benign-diseases-during-pregnancy-a-nationwide-retrospective-cohort-study
#5
Daisuke Shigemi, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
STUDY OBJECTIVE: To compare fetal, maternal, and operative outcomes of laparoscopic surgery versus laparotomy for major benign diseases including appendicitis, cholecystitis, adnexal masses, and uterine myoma during pregnancy. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: The Diagnosis Procedure Combination database, a national inpatient database for acute-care inpatients in Japan. PATIENTS: 6,018 eligible patients underwent abdominal surgery (4,047 laparotomy and 1,971 laparoscopy patients) from July 2010 through March 2016...
June 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29908339/radical-hysterectomy-efficacy-and-safety-in-the-dawn-of-minimally-invasive-techniques
#6
Antonio Gil-Moreno, Melchor Carbonell-Socias, Sabina Salicrú, Cristina Centeno-Mediavilla, Silvia Franco-Camps, Eva Colas, Ana Oaknin, Assumpció Pérez-Benavente, Berta Díaz-Feijoo
STUDY OBJECTIVE: To analyze the effect that the introduction of minimally invasive procedures has had on surgical and oncological outcomes when compared with conventional open radical hysterectomy (ORH) in a national reference cancer after 17 years of experience in radical hysterectomy (RH). DESIGN: A prospective controlled study (Canadian Task Force II-2) SETTING: A university teaching hospital PATIENTS: All patients that underwent RH as primary treatment for cervical cancer in our institution between May 1999 and June 2016, with a total of 188 patients...
June 13, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29907511/developing-and-assessing-electronic-checklists-for-safety-mindfulness-workload-and-performance
#7
Gregg S Tracton, Lukasz M Mazur, Prithima Mosaly, Lawrence B Marks, Shiva Das
PURPOSE: The aim of this study is to propose a set of innovative principles for the effective design of electronic checklists to enhance safety mindfulness (a specific safety mindful mindset that offers the opportunity to operate more preemptively during routine quality assurance tasks) and discuss some of our preliminary results from testing our proposed electronic checklist with dosimetrists and physicists. METHODS AND MATERIALS: A multidisciplinary team designed, developed, and evaluated the utility of the electronic checklist (vs paper-based checklist) to promote safety mindfulness...
May 16, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29907503/real-time-management-of-incident-learning-reports-in-a-radiation-oncology-department
#8
REVIEW
Jean L Wright, Arti Parekh, Byung-Han Rhieu, Valentina Opris, Annette Souranis, Amanda Choflet, Akila N Viswanathan, Theodore L DeWeese, Todd McNutt, Stephanie A Terezakis
PURPOSE: The optimal approach to managing incident learning system (ILS) reports remains unclear. Here, we describe our experience with prospective coding of events reported to the ILS with comparisons of risk scores on the basis of event type and process map location. METHODS AND MATERIALS: Reported events were coded by type, origin, and method of discovery. Events were given a risk priority number (RPN) and near-miss risk index (NMRI) score. We compared workflow versus near-miss events with respect to origin and detection in the process map and by risk scores...
May 8, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29907271/automation-of-mechanical-ventilation
#9
REVIEW
Richard D Branson
Closed loop control of mechanical ventilation is routine and operates behind the ventilator interface. Reducing caregiver interactions is neither an advantage for the patient or the staff. Automated systems causing lack of situational awareness of the intensive care unit are a concern. Along with autonomous systems must come monitoring and displays that display patients' current condition and response to therapy. Alert notifications for sudden escalation of therapy are required to ensure patient safety. Automated ventilation is useful in remote settings in the absence of experts...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907208/well-differentiated-thyroid-cancer-and-robotic-transaxillary-surgery-at-a-north-american-institution
#10
Meghan Garstka, Khuzema Mohsin, Daniah Bu Ali, Hosam Shalaby, Kareem Ibraheem, Mahmoud Farag, Sang-Wook Kang, Emad Kandil
BACKGROUND: Recent studies from Asia have reported the safety and feasibility of robotic-assisted thyroid surgery. In the United States, several small series and case reports have been published, mostly regarding treatment of benign disease. The aim of our study is to report the safety and feasibility of robotic surgery for well-differentiated thyroid cancer patients at a North American institution. MATERIALS AND METHODS: We performed a retrospective cohort study using a prospectively collected single-center clinical database at Tulane University Medical Center...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906644/retroperitoneal-versus-open-intraperitoneal-necrosectomy-in-step-up-therapy-for-infected-necrotizing-pancreatitis-a-meta-analysis
#11
REVIEW
Yun-Bing Wang, Xiao-Li Yang, Long Chen, Zheng-Ju Chen, Chun-Mu Miao, Jin Xia
BACKGROUND: Step-up therapy is the recommended therapy for infected necrotizing pancreatitis (INP). However, the most appropriate secondary therapy for use after initial drainage has not been fully determined. This meta-analysis was designed to evaluate the efficacy and safety of retroperitoneal versus open intraperitoneal necrosectomy as part of a step-up strategy for INP. MATERIALS AND METHODS: Eight online databases were searched for randomized controlled trials (RCTs) and cohorts comparing retroperitoneal and open intraperitoneal step-up approaches for treating INP...
June 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29906498/discovering-time-trends-of-the-german-populations-exposure-to-contaminants-by-analysis-of-human-samples-of-the-german-environmental-specimen-bank-esb
#12
Thomas Göen, Dominik Lermen, Jörg Hildebrand, Martina Bartel-Steinbach, Till Weber, Marike Kolossa-Gehring
The German Environmental Specimen Bank (ESB) is a monitoring instrument of the German Federal Ministry for the Environment, Nature Conservationand Nuclear Safety. The permanent biobank facility is run since 1981 containing environmental and human samples from Germany. All samples are collected according to standard operating procedures (SOP). An annually standardized collection of human samples at four different regional sites of the country has been established since 1997. Routine sampling is done once a year, recruiting healthy non occupationally exposed students aged 20-29 years, in an equal gender distribution...
June 12, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29906266/radiation-safety-in-the-catheterization-laboratory-current-perspectives-and-practices
#13
Rohan Menon, Aris Karatasakis, Siddharth Patel, Barbara A Danek, Judit Karacsonyi, Bavana V Rangan, Tayo Addo, Dharam Kumbhani, Samir Kapadia, Michael Luna, Ehtisham Mahmud, Charles Chambers, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: There is great variability in radiation safety practices in cardiac catheterization laboratories around the world. METHODS: We performed an international online survey on radiation safety including interventional cardiologists, electrophysiologists, interventional radiologists, and vascular surgeons. RESULTS: A total of 570 responses were received from various geographic locations, including the United States (77.9%), Asia (7.9%), Europe (6...
June 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29906265/transcatheter-mitral-valve-in-valve-and-valve-in-ring-replacement-in-high-risk-surgical-patients-feasibility-safety-and-longitudinal-outcomes-in-a-single-center-experience
#14
Ashleigh Long, Paul Mahoney
BACKGROUND: Transcatheter mitral valve-in-valve (TMVIV) or valve-in-ring (TMVIR) replacement has shown early promise in patients deemed poor surgical candidates as a less invasive alternative to conventional reoperative mitral valve (MV) replacement. OBJECTIVE: This retrospective, single-center study reviewed the procedural outcomes of all TMVIV and TMVIR procedures between 2013-2018 at a large tertiary referral center serving the southeastern United States. An analysis of patient safety measures was also performed, with a retrospective assessment of relative procedural safety that included preoperative risk stratification and postoperative mortality predictors, operative time, average blood loss, length of hospital stay, and readmission rates...
June 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29904745/promoting-safety-mindfulness-recommendations-for-the-design-and-use-of-simulation-based-training-in-radiation-therapy
#15
REVIEW
Lukasz M Mazur, Lawrence B Marks, Ron McLeod, Waldemar Karwowski, Prithima Mosaly, Gregg Tracton, Robert D Adams, Lesley Hoyle, Shiva Das, Bhishamjit Chera
There is a need to better prepare radiation therapy (RT) providers to safely operate within the health information technology (IT) sociotechnical system. Simulation-based training has been preemptively used to yield meaningful improvements during providers' interactions with health IT, including RT settings. Therefore, on the basis of the available literature and our experience, we propose principles for the effective design and use of simulated scenarios and describe a conceptual framework for a debriefing approach to foster successful training that is focused on safety mindfulness during RT professionals' interactions with health IT...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29904632/the-use-of-the-goldfinger-dissector-gd-in-laparoscopic-sacrocolpopexy
#16
Pascal Talla, Maria Ekotomati, Tara O'Leary, Nordine Ben Ali
We tested the employment of the GD to create a retroperitoneal tunnel between the promontory and the vaginal apex during the laparoscopic sacrocolpopexy with a mesh. Thus far no report has experimented the use of the GD in this indication. This study's aim was to evaluate the safety and the interest to use this laparoscopic instrument. Sixteen consecutive patients underwent a laparoscopic sacrocolpopexy with the use of the GD and were compared with a control group constituted by the previous 30 cases. The median operating time was 180 min with the use of the GD and represent a gain of time of 22 min in comparaison with our control group...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29904601/incidence-and-risk-factors-for-complications-after-definitive-skeletal-fixation-of-lower-extremity-in-multiple-injury-patients-a-retrospective-chart-review
#17
Thananit Sangkomkamhang, Wilaiphorn Thinkhamrop, Bandit Thinkhamrop, Wongsa Laohasiriwong
Background : The management of multiple injuries is complex. Type and timing of treatment for lower extremity fractures is a controversial subject. Although many studies have demonstrated the safety and effectiveness of early treatment, others have suggested that early definitive stabilization may cause complications, especially with chest and head injuries. The aim of this study was to determine the complications and effects of timing of fixation, and investigate risk factors for complications in multiple injuries patients with lower extremity fractures...
2018: F1000Research
https://www.readbyqxmd.com/read/29904451/thrombolysis-is-an-effective-and-safe-therapy-in-stuck-mitral-valves-with-delayed-presentation-as-well-as-hemodynamically-unstable-patients-a-single-centre-study
#18
Arun Shivajirao Bade, Shakil Sattar Ahmed Shaikh, Hemant Khemani, Gurkirat Singh, Narender Omprakash Bansal
Background: Thrombosis is a complication of prosthetic valves on oral anticoagulants which is associated with significant morbidity and mortality. A re-operation carries a substantial risk, with mortality rate from 10% to 15% in selected series, which may be 2- or 3-folds higher in critically ill patients. This study conducted in a tertiary care cardiology unit aimed to evaluate the effectiveness and safety of thrombolytic therapy in stuck mitral bileaflet heart valves. Methods: As a prospective observational study, clinical symptoms and fluoroscopy were the mainstay in diagnosis of stuck mitral valve...
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29904375/quantifying-the-responses-of-three-bacillus-cereus-strains-in-isothermal-conditions-and-during-spray-drying-of-different-carrier-agents
#19
Verônica O Alvarenga, Fernanda B Campagnollo, Arthur K R Pia, Deborah A Conceição, Yuri Abud, Celso Sant'Anna, Miriam D Hubinger, Anderson S Sant'Ana
Spray drying is a widely used method for producing milk powder. This process is not aimed to cause microbial inactivation, thus sporeforming bacteria may be abundant in the microbiota of milk powder. The first aim of this study was to determine the inactivation kinetics parameters in capillary tubes of three Bacillus cereus strains (436, B63, 540) in three menstrua (whole milk, phosphate buffer, and talc suspension) at 90, 100, and 110°C. D -values for B. cereus in the three menstrua were not significantly different at the highest tested temperature ( p > 0...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29903799/the-silkie-skin-grafting-low-friktion-environment-study-a-non-randomised-proof-of-concept-and-feasibility-study-on-the-impact-of-low-friction-nursing-environment-on-skin-grafting-success-rates-in-adult-and-paediatric-burns
#20
Linda Hollén, Rosemary Greenwood, Rebecca Kandiyali, Jenny Ingram, Chris Foy, Susan George, Sandra Mulligan, Francesca Spickett-Jones, Simon Booth, Anthony Sack, Alan Emond, Ken Dunn, Amber Young
OBJECTIVES: To evaluate the impact of low-friction (LF) bedding on graft loss in an acute burn care setting, and to examine the feasibility and costs of using LF bedding compared with standard care. DESIGN: Proof of concept before and after study with feasibility of delivering the intervention. SETTING: Three burns services within two UK hospital trusts. PARTICIPANTS: Inclusion criteria were patients older than 4 weeks, who received a skin graft after burn injury and were admitted overnight...
June 14, 2018: BMJ Open
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