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https://www.readbyqxmd.com/read/28809740/early-successes-in-an-open-access-provincially-funded-hepatitis-c-treatment-program-in-prince-edward-island
#1
Daniel Smyth, Jordan W Francheville, Robin Rankin, Jeremy Beck, Connie Hoare, Stefanie Materniak, Greg German, Lisa Barrett, Natalie Bunimov-Wall
INTRODUCTION: The availability of curative hepatitis C therapies has created an opportunity to improve delivery and access. Local providers, government, industry, and community groups in Prince Edward Island developed an innovative province-wide care model. Our goal was to describe the first year of program implementation. MATERIAL AND METHODS: Using a community based prospective observational study design, all chronic hepatitis C referrals received from April 2015 to April 2016 were recorded in a database...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28809734/wait-time-for-curative-intent-radio-frequency-ablation-is-associated-with-increased-mortality-in-patients-with-early-stage-hepatocellular-carcinoma
#2
Mayur Brahmania, Osman Ahmed, Melissa Kelley, David Wong, Matthew Kowgier, Korosh Khalili, Rob Beecroft, Eberhard L Renner, Hemant Shah, Jordan Feld, Harry L A Janssen, Morris Sherman
INTRODUCTION: Radiofrequency ablation (RFA) is a recommended curative intent treatment option for patients with early stage hepatocellular carcinoma (HCC). We investigated if wait times for RFA were associated with residual tumor, tumor recurrence, need for liver transplantation, or death. MATERIAL AND METHODS: We conducted a retrospective study of patients diagnosed with HCC between January 2010 and December 2013 presenting to University Health Network (UHN) in Toronto, Canada...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28807254/minimally-invasive-gastrectomy-for-gastric-cancer-a-national-perspective-on-oncologic-outcomes-and-overall-survival
#3
Kenneth Leung, Zhifei Sun, Daniel P Nussbaum, Mohamed A Adam, Mathias Worni, Dan G Blazer
BACKGROUND: Minimally invasive (MI) gastrectomy has become increasingly common as a resection technique for gastric cancer; however, data are limited regarding peri-operative morbidity, oncologic outcomes and long-term survival, particularly in the Western patient population. STUDY DESIGN: The 2010-2012 National Cancer Data Base was queried for adult patients who underwent gastrectomy for localized, intestinal-type gastric adenocarcinoma. Patients were classified by surgical approach (MI vs...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28805162/automated-telecommunication-interventions-to-promote-adherence-to-cardio-metabolic-medications-meta-analysis-of-effectiveness-and-meta-regression-of-behaviour-change-techniques
#4
Aikaterini Kassavou, Stephen Sutton
Automated telecommunication interventions, including short message service and interactive voice response, are increasingly being used to promote adherence to medications prescribed for cardio-metabolic conditions. This systematic review aimed to comprehensively assess the effectiveness of such interventions to support medication adherence, and to identify the Behaviour Change Techniques (BCTs) and other intervention characteristics that are positively associated with greater intervention effectiveness. Meta-analysis of 17 randomised controlled trials showed a small but statistically significant effect on medication adherence OR=1...
August 14, 2017: Health Psychology Review
https://www.readbyqxmd.com/read/28804684/bioresorbable-scaffold-as-a-dermal-substitute
#5
Lenon Cardoso, Marília Colturato Cleto, Maria Lourdes Peris Barbo, Andréa Rodrigues Esposito, Flavio Stillitano Orgaes, Eliana Aparecida de Rezende Duek
INTRODUCTION: Bioresorbable polymers are often used in medical procedures. Since they are biocompatible, this class of materials is a viable alternative for cases in which tissue regeneration is strongly compromised. Bioresorbable synthetic polymers may be used as membranes to support and guide cell growth through the process of tissue repair. OBJECTIVE: To assess the efficiency of a porous bioresorbable membrane Poly (L-co-DL lactic acid)-co-trimethylene carbonate, PL-co-DLA-co-TMC, as a dermal substitute associated with partial skin graft in rats...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/28802331/preliminary-physician-and-pharmacist-survey-of-the-national-health-insurance-pharmacloud-system-in-taiwan
#6
Yu-Ting Tseng, Elizabeth H Chang, Li-Na Kuo, Wan-Chen Shen, Kuan-Jen Bai, Chih-Chi Wang, Hsiang-Yin Chen
BACKGROUND: The PharmaCloud system, a cloud-based medication system, was launched by the Taiwan National Health Insurance Administration (NHIA) in 2013 to integrate patients' medication lists among different medical institutions. The aim of the preliminary study was to evaluate satisfaction with this system among physicians and pharmacists at the early stage of system implementation. METHODS: A questionnaire was developed through a review of the literature and discussion in 6 focus groups to understand the level of satisfaction, attitudes, and intentions of physicians and pharmacists using the PharmaCloud system...
October 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28800941/survival-and-safety-associated-with-aggressive-surgery-for-stage-iii-iv-epithelial-ovarian-cancer-a-single-institution-observation-study
#7
Shinichi Tate, Kazuyoshi Kato, Kyoko Nishikimi, Ayumu Matsuoka, Makio Shozu
OBJECTIVE: We evaluated the efficacy and safety of aggressive surgery for advanced ovarian cancer at a non-high-volume center. MATERIALS AND METHODS: We evaluated consecutive patients with stage III/IV ovarian, fallopian, and peritoneal cancer undergoing elective aggressive surgery from January 2008 to December 2012, which encompassed the first 5years after implementing an aggressive surgery protocol. After receiving appropriate training for 9months, a gynecological surgical team began performing multi-visceral resections...
August 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28794919/where-are-the-svhcs-10%C3%A2-years-consumer-s-right-to-know-about-substances-of-very-high-concern
#8
Ursula Klaschka
BACKGROUND: The European chemicals regulation REACH includes the legal duty for suppliers to inform consumers on request about the presence of substances of very high concern (SVHCs) in articles. Since this requirement has been in force now for 10 years, the intention of this study was to find out whether information on SVHCs is adequately communicated to the consumer today. Data on the presence of SVHCs in articles were collected as a prerequisite for the subsequent requests for a targeted choice of articles to examine the operability of the 'right to know...
2017: Environmental Sciences Europe
https://www.readbyqxmd.com/read/28779963/partial-breast-radiotherapy-after-breast-conservation-surgery-for-patients-with-early-breast-cancer-uk-import-low-trial-5-year-results-from-a-multicentre-randomised-controlled-phase-3-non-inferiority-trial
#9
Charlotte E Coles, Clare L Griffin, Anna M Kirby, Jenny Titley, Rajiv K Agrawal, Abdulla Alhasso, Indrani S Bhattacharya, Adrian M Brunt, Laura Ciurlionis, Charlie Chan, Ellen M Donovan, Marie A Emson, Adrian N Harnett, Joanne S Haviland, Penelope Hopwood, Monica L Jefford, Ronald Kaggwa, Elinor J Sawyer, Isabel Syndikus, Yat M Tsang, Duncan A Wheatley, Maggie Wilcox, John R Yarnold, Judith M Bliss
BACKGROUND: Local cancer relapse risk after breast conservation surgery followed by radiotherapy has fallen sharply in many countries, and is influenced by patient age and clinicopathological factors. We hypothesise that partial-breast radiotherapy restricted to the vicinity of the original tumour in women at lower than average risk of local relapse will improve the balance of beneficial versus adverse effects compared with whole-breast radiotherapy. METHODS: IMPORT LOW is a multicentre, randomised, controlled, phase 3, non-inferiority trial done in 30 radiotherapy centres in the UK...
August 2, 2017: Lancet
https://www.readbyqxmd.com/read/28771564/student-anxiety-in-introductory-biology-classrooms-perceptions-about-active-learning-and-persistence-in-the-major
#10
Benjamin J England, Jennifer R Brigati, Elisabeth E Schussler
Many researchers have called for implementation of active learning practices in undergraduate science classrooms as one method to increase retention and persistence in STEM, yet there has been little research on the potential increases in student anxiety that may accompany these practices. This is of concern because excessive anxiety can decrease student performance. Levels and sources of student anxiety in three introductory biology lecture classes were investigated via an online survey and student interviews...
2017: PloS One
https://www.readbyqxmd.com/read/28770631/go-grrrls-a-randomized-controlled-trial-of-a-gender-specific-intervention-to-reduce-sexual-risk-factors-in-middle-school-females
#11
Craig Winston LeCroy, Jenny McCullough Cosgrove, Katie Cotter, Marie Fordney
PURPOSE: Adolescent females continue to face health consequences associated with risky sexual behaviors such as unintended pregnancies and sexually transmitted diseases. The purpose of this study was to investigate the efficacy of a gender-specific intervention targeted to early adolescent females. METHOD: This study used an intent to treat randomized clinical trial comparing a broad-based female empowerment curriculum with a dose-matched science and technology female leadership curriculum...
August 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28770596/high-rates-of-viral-suppression-in-adults-and-children-with-high-cd4-counts-using-a-streamlined-art-delivery-model-in-the-search-trial-in-rural-uganda-and-kenya
#12
Dalsone Kwarisiima, Moses R Kamya, Asiphas Owaraganise, Florence Mwangwa, Dathan M Byonanebye, James Ayieko, Albert Plenty, Doug Black, Tamara D Clark, Bridget Nzarubara, Katherine Snyman, Lillian Brown, Elizabeth Bukusi, Craig R Cohen, Elvin H Geng, Edwin D Charlebois, Theodore D Ruel, Maya L Petersen, Diane Havlir, Vivek Jain
INTRODUCTION: The 2015 WHO recommendation of antiretroviral therapy (ART) for all HIV-positive persons calls for treatment initiation in millions of persons newly eligible with high CD4+ counts. Efficient and effective care models are urgently needed for this population. We evaluated clinical outcomes of asymptomatic HIV-positive adults and children starting ART with high CD4+ counts using a novel streamlined care model in rural Uganda and Kenya. METHODS: In the 16 intervention communities of the HIV test-and-treat Sustainable East Africa Research for Community Health Study (NCT01864603), all HIV-positive individuals irrespective of CD4 were offered ART (efavirenz [EFV]/tenofovir disoproxil fumarate + emtricitabine (FTC) or lamivudine (3TC)...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28768608/web-based-medical-service-technology-attractiveness-medical-creditability-information-source-and-behavior-intention
#13
Shan Huei Wang
BACKGROUND: Web-based medical service (WBMS), a cooperative relationship between medical service and Internet technology, has been called one of the most innovative services of the 21st century. However, its business promotion and implementation in the medical industry have neither been expected nor executed. Few studies have explored this phenomenon from the viewpoint of inexperienced patients. OBJECTIVE: The primary goal of this study was to explore whether technology attractiveness, medical creditability, and diversified medical information sources could increase users' behavior intention...
August 2, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28766463/long-term-effects-of-directed-forgetting
#14
Almut Hupbach
The intention to forget reduces the accessibility of information in memory, which is commonly explained with temporary retrieval difficulties. Long-term effects have rarely been studied, and results are inconsistent. The present study re-assessed the long-term effects of directed forgetting (DF). Participants encoded a first list of items (L1), and were then instructed to forget or to remember this list. Immediately afterwards, all participants were presented with a second list to remember. In Experiment 1, memory for L1 and L2 was assessed after a 24-h delay...
August 2, 2017: Memory
https://www.readbyqxmd.com/read/28766191/promoting-afterschool-quality-and-positive-youth-development-cluster-randomized-trial-of-the-pax-good-behavior-game
#15
Emilie Phillips Smith, D Wayne Osgood, Yoonkyung Oh, Linda C Caldwell
This randomized trial tested a strategy originally developed for school settings, the Pax Good Behavior Game (PAX GBG), in the new context of afterschool programs. We examined this approach in afterschool since 70% of all juvenile crime occurs between the hours of 3-6 pm, making afterschool an important setting for prevention and promotion. Dual-career and working families need monitoring and supervision for their children in quality settings that are safe and appropriately structured. While substantial work has identified important features of afterschool programs, increasing attention is being given to how to foster quality...
August 1, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28765104/a-technological-innovation-to-reduce-prescribing-errors-based-on-implementation-intentions-the-acceptability-and-feasibility-of-myprescribe
#16
Chris Keyworth, Jo Hart, Hong Thoong, Jane Ferguson, Mary Tully
BACKGROUND: Although prescribing of medication in hospitals is rarely an error-free process, prescribers receive little feedback on their mistakes and ways to change future practices. Audit and feedback interventions may be an effective approach to modifying the clinical practice of health professionals, but these may pose logistical challenges when used in hospitals. Moreover, such interventions are often labor intensive. Consequently, there is a need to develop effective and innovative interventions to overcome these challenges and to improve the delivery of feedback on prescribing...
August 1, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28764679/economic-evaluation-of-stepped-care-versus-usual-care-for-depression-and-anxiety-in-older-adults-with-vision-impairment-randomized-controlled-trial
#17
Hilde P A van der Aa, Ger H M B van Rens, Judith E Bosmans, Hannie C Comijs, Ruth M A van Nispen
BACKGROUND: A stepped-care program was found effective in preventing depressive and anxiety disorders in older adults with vision impairment. However, before a decision can be made about implementation, the cost-effectiveness of this program should be investigated. Therefore, we aimed to compare the cost-effectiveness of stepped-care versus usual care within low vision rehabilitation. METHODS: An economic evaluation from a societal perspective was performed alongside a multicenter randomized controlled trial...
August 1, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28764673/exploring-coronial-determination-of-intent-for-poisoning-related-deaths-in-australia-2001-2013
#18
Kate Churruca, Rebecca Mitchell
BACKGROUND: In countries like the United States and the United Kingdom, systematic variation in the classification of intent in pharmaceutical poisoning deaths have been identified between jurisdictions. This study aimed to explore whether the coronial determination of intent (unintentional, intentional, undetermined) for pharmaceutical-related poisoning deaths may have affected death rates over time and by jurisdiction in Australia. METHODS: A retrospective examination of mortality records in the National Coronial Information System (NCIS) during 1 January 2001 to 31 December 2013 was conducted...
August 1, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28760784/tablet-technology-in-medical-education-in-south-africa-a-mixed-methods-study
#19
L Lazarus, R Sookrajh, K S Satyapal
OBJECTIVE: The purpose of this study was to establish the use of mobile devices by learners at a selected medical school. Distribution of mobile devices was an inaugural initiative implemented by our college. DESIGN: A mixed methodology design using a questionnaire comprising both open-ended and close-ended questions was analysed from 179 (60 male; 119 female) second year medical students registered for the Anatomy course. Open-ended questions were analysed using a thematic approach by identifying emergent ideas and concepts...
July 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28758540/using-the-theoretical-domains-framework-to-guide-the-development-of-a-self-management-program-for-individuals-with-spinal-cord-injury-results-from-a-national-stakeholder-advisory-group
#20
Sarah E P Munce, Sonya Allin, Dalton L Wolfe, Karen Anzai, Gary Linassi, Vanessa K Noonan, Susan B Jaglal
OBJECTIVE: To determine the implementation considerations for a targeted self-management program for individuals with spinal cord injury (SCI) from the perspective of a national stakeholder advisory group using the Theoretical Domains Framework (TDF) as a guide. DESIGN: Qualitative descriptive approach. SETTING: Two focus groups held at the 6(th) National Spinal Cord Injury Conference (October 2-4(th), 2014) in Toronto, Ontario, Canada. PARTICIPANTS: A total of 25 stakeholders from across Canada participated in focus groups or "brainstorming sessions"...
July 30, 2017: Journal of Spinal Cord Medicine
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