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https://www.readbyqxmd.com/read/29150390/pulmonary-embolism-rule-out-criteria-perc-rule-in-european-patients-with-low-implicit-clinical-probability-percepic-a-multicentre-prospective-observational-study
#1
Andrea Penaloza, Caroline Soulié, Thomas Moumneh, Quentin Delmez, Alexandre Ghuysen, Dominique El Kouri, Christian Brice, Nicolas S Marjanovic, Jacques Bouget, Fares Moustafa, Albert Trinh-Duc, Catherine Le Gall, Lionel Imsaad, Jean-Marie Chrétien, Béatrice Gable, Philippe Girard, Olivier Sanchez, Jeannot Schmidt, Grégoire Le Gal, Guy Meyer, Nicolas Delvau, Pierre-Marie Roy
BACKGROUND: The ability of the pulmonary embolism rule-out criteria (PERC) to exclude pulmonary embolism without further testing remains debated outside the USA, especially in the population with suspected pulmonary embolism who have a high prevalence of the condition. Our main objective was to prospectively assess the predictive value of negative PERC to rule out pulmonary embolism among European patients with low implicit clinical probability. METHODS: We did a multicentre, prospective, observational study in 12 emergency departments in France and Belgium...
November 14, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29149194/understanding-linkage-to-care-with-hiv-self-test-approach-in-lusaka-zambia-a-mixed-method-approach
#2
Jenala Chipungu, Samuel Bosomprah, Arianna Zanolini, Harsha Thimurthy, Roma Chilengi, Anjali Sharma, Charles B Holmes
INTRODUCTION: HIV self-testing (HIVST) is a novel approach designed to assist in achieving the goal of at least 90% of the population that learn their HIV status. A self-test user with a positive test is required to visit a clinic to link into HIV care, yet little is known about patient preferences for linkage strategies. We examined the intention to link to care amongst potential HIVST users and the suitability of three linkage to care strategies in Lusaka Province, Zambia. METHODS: We conducted a representative cross sectional survey of 1,617 individuals aged 16-49 years old in Lusaka Province...
2017: PloS One
https://www.readbyqxmd.com/read/29148311/for-which-clinical-rules-do-doctors-want-decision-support-and-why-a-survey-of-dutch-general-practitioners
#3
Stephanie Medlock, Saeid Eslami, Marjan Askari, Derk L Arts, Esther M van de Glind, Henk J Brouwer, Henk C van Weert, Sophia E de Rooij, Ameen Abu-Hanna
Despite the promise of decision support for improving care, alerts are often overridden or ignored. We evaluated Dutch general practitioners' intention to accept decision support in a proposed implementation based on clinical rules regarding care for elderly patients, and their reasons for wanting or not wanting support. We developed a survey based on literature and structured interviews and distributed it to all doctors who would receive support in the proposed implementation (n = 43), of which 65 percent responded...
November 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/29148146/factors-influencing-nurse-assessed-quality-nursing-care-a-cross-sectional-study-in-hospitals
#4
Ying Liu, Yupin Aungsuroch
AIM: To propose a hypothesized theoretical model and apply it to examine the structural relationships among work environment, patient-to-nurse ratio, job satisfaction, burnout, intention to leave and quality nursing care. BACKGROUND: Improving quality nursing care is a first consideration in nursing management globally. A better understanding of factors influencing quality nursing care can help hospital administrators implement effective programs to improve quality of services...
November 17, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29146401/neratinib-after-trastuzumab-based-adjuvant-therapy-in-her2-positive-breast-cancer-extenet-5-year-analysis-of-a-randomised-double-blind-placebo-controlled-phase-3-trial
#5
Miguel Martin, Frankie A Holmes, Bent Ejlertsen, Suzette Delaloge, Beverly Moy, Hiroji Iwata, Gunter von Minckwitz, Stephen K L Chia, Janine Mansi, Carlos H Barrios, Michael Gnant, Zorica Tomašević, Neelima Denduluri, Robert Šeparović, Erhan Gokmen, Anna Bashford, Manuel Ruiz Borrego, Sung-Bae Kim, Erik Hugger Jakobsen, Audrone Ciceniene, Kenichi Inoue, Friedrich Overkamp, Joan B Heijns, Anne C Armstrong, John S Link, Anil Abraham Joy, Richard Bryce, Alvin Wong, Susan Moran, Bin Yao, Feng Xu, Alan Auerbach, Marc Buyse, Arlene Chan
BACKGROUND: ExteNET showed that 1 year of neratinib, an irreversible pan-HER tyrosine kinase inhibitor, significantly improves 2-year invasive disease-free survival after trastuzumab-based adjuvant therapy in women with HER2-positive breast cancer. We report updated efficacy outcomes from a protocol-defined 5-year follow-up sensitivity analysis and long-term toxicity findings. METHODS: In this ongoing randomised, double-blind, placebo-controlled, phase 3 trial, eligible women aged 18 years or older (≥20 years in Japan) with stage 1-3c (modified to stage 2-3c in February, 2010) operable breast cancer, who had completed neoadjuvant and adjuvant chemotherapy plus trastuzumab with no evidence of disease recurrence or metastatic disease at study entry...
November 13, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29145852/a-preliminary-evaluation-of-influence-of-body-mass-index-on-in-vitro-fertilization-outcome-in-non-obese-endometriosis-patients
#6
Eliana Garalejic, Biljana Arsic, Jovana Radakovic, Dragana Bojovic Jovic, Dragana Lekic, Biljana Macanovic, Ivan Soldatovic, Milan Perovic
BACKGROUND/AIMS: Obese and overweight women experience a lower probability for pregnancy after IVF. However, despite the increasing prevalence of obesity, the large majority of infertile women are non-obese. One of the most common indications for IVF is endometriosis. Thought-provoking inverse correlation has been established between BMI and endometriosis. Lower BMI is a risk factor for development of endometriosis and a predictive factor for severe endometriosis. Since severe endometriosis carries lower reproductive chances, even after IVF, we preliminary tested a hypothesis that higher BMI among non-obese endometriosis patients improves IVF outcomes...
November 16, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29143456/early-intervention-in-psychosis-from-clinical-intervention-to-health-system-implementation
#7
Claudio Csillag, Merete Nordentoft, Masafumi Mizuno, David McDaid, Celso Arango, Jo Smith, Antonio Lora, Swapna Verma, Teresa Di Fiandra, Peter B Jones
AIM: Early intervention in psychosis (EIP) is a well-established approach with the intention of early detection and treatment of psychotic disorders. Its clinical and economic benefits are well documented. This paper presents basic aspects of EIP services, discusses challenges to their implementation and presents ideas and strategies to overcome some of these obstacles. METHODS: This paper is a narrative review about the evidence supporting EIP, with examples of successful implementation of EIP and of cases where major obstacles still need to be overcome...
November 16, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29141719/chloroquine-primaquine-versus-chloroquine-alone-to-treat-vivax-malaria-in-afghanistan-an-open-randomized-superiority-trial
#8
Ghulam Rahim Awab, Mallika Imwong, Germana Bancone, Atthanee Jeeyapant, Nicholas P J Day, Nicholas J White, Charles J Woodrow
Afghanistan's national guidelines recommend primaquine (PQ) for radical treatment of Plasmodium vivax malaria, but this is rarely implemented because of concerns over potential hemolysis in patients who have G6PD deficiency. Between August 2009 and February 2014, we conducted an open-label, randomized controlled trial of chloroquine (CQ) alone versus chloroquine plus primaquine (0.25 mg base/kg/day for 14 days) (CQ+PQ) in patients aged 6 months and older with microscopy confirmed P. vivax infection. In the CQ+PQ group, G6PD deficiency was excluded by fluorescent spot testing...
October 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29137839/predictors-of-intention-of-reporting-child-abuse-among-emergency-nurses
#9
Hye-Mi Lee, Ji-Soo Kim
PURPOSE: The current study investigates predictors of intention of reporting child abuse among emergency nurses in Korea. DESIGN AND METHODS: A descriptive cross-sectional design was used. Data were collected from 200 emergency nurses in eight general hospitals in Korea through a questionnaire that asked about their general characteristics, knowledge about child abuse, perceived behavioral control, experiences of child abuse cases and reporting, and attitude toward child abuse...
November 11, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29137659/the-effectiveness-of-research-implementation-strategies-for-promoting-evidence-informed-policy-and-management-decisions-in-healthcare-a-systematic-review
#10
REVIEW
Mitchell N Sarkies, Kelly-Ann Bowles, Elizabeth H Skinner, Romi Haas, Haylee Lane, Terry P Haines
BACKGROUND: It is widely acknowledged that health policy and management decisions rarely reflect research evidence. Therefore, it is important to determine how to improve evidence-informed decision-making. The primary aim of this systematic review was to evaluate the effectiveness of research implementation strategies for promoting evidence-informed policy and management decisions in healthcare. The secondary aim of the review was to describe factors perceived to be associated with effective strategies and the inter-relationship between these factors...
November 14, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29134434/fluoroscopy-free-af-ablation-using-transesophageal-echocardiography-and-electroanatomical-mapping-technology
#11
Benjamin O'Brien, Damian C Balmforth, Ross J Hunter, Richard J Schilling
PURPOSE: Guidelines recommend that radiation exposure during AF catheter ablation procedures should be 'as low as reasonably achievable' (ALARA), particularly since many patients may have multiple procedures. Consequently, avoiding radiation exposure altogether must, if safe to do so, be the ultimate goal. The primary objective was to determine the feasibility and efficacy of fluoroscopy-free AF ablation compared to the fluoroscopy-assisted procedure. METHODS: Patients underwent AF ablation using commercially available technology with no routine pre-procedural imaging...
November 14, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29133014/incorporation-of-brentuximab-vedotin-into-first-line-treatment-of-advanced-classical-hodgkin-s-lymphoma-final-analysis-of-a-phase-2-randomised-trial-by-the-german-hodgkin-study-group
#12
Dennis A Eichenauer, Annette Plütschow, Stefanie Kreissl, Martin Sökler, Johannes C Hellmuth, Julia Meissner, Stephan Mathas, Max S Topp, Karolin Behringer, Wolfram Klapper, Georg Kuhnert, Markus Dietlein, Carsten Kobe, Michael Fuchs, Volker Diehl, Andreas Engert, Peter Borchmann
BACKGROUND: A high proportion of patients with relapsed classical Hodgkin's lymphoma achieve a response with the antibody-drug conjugate brentuximab vedotin, and the drug is well tolerated. We modified the escalated BEACOPP regimen (eBEACOPP; bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) and implemented brentuximab vedotin with the aim to reduce toxic effects while maintaining the protocol's efficacy. METHODS: We did an open-label, multicentre, randomised phase 2 study at 20 study sites in Germany...
November 10, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29131333/examining-the-characteristics-and-clinical-features-of-in-and-between-session-suicide-risk-assessments-among-psychiatric-outpatients
#13
Melanie A Hom, Ian H Stanley, Megan L Rogers, Julia L Sheffler, Katherine R Nelson, Thomas E Joiner, Elisabeth Schramm
OBJECTIVE: To evaluate the characteristics of suicide risk assessments completed using the Decision Tree framework both in and between psychotherapy sessions, clinical features of patients for whom between-session assessments are indicated, and data collected across assessments. METHOD: Data were collected from 1,358 suicide risk assessments conducted with psychiatric outpatients (N = 41) at elevated suicide risk engaged in care at a psychology training clinic...
November 13, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29131195/compact-single-shot-d-scan-setup-for-the-characterization-of-few-cycle-laser-pulses
#14
Maïté Louisy, Chen Guo, Lana Neoričić, Shiyang Zhong, Anne L'Huillier, Cord L Arnold, Miguel Miranda
We present a compact implementation of the ultrashort pulse measurement technique based on dispersion scans (d-scan), allowing single-shot measurement of few-cycle pulses. The main novelty in our design, making our setup extremely compact and simple, is the use, after a prism, of a spherical mirror in an off-axis geometry. The intentionally introduced strong astigmatism makes it possible to image the output of the crystal in one direction while focusing it in the other direction, resulting in the output face of the prism being imaged into a line in the second-harmonic crystal...
November 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29126341/-acceptance-of-online-based-therapy-by-patients-with-light-to-moderate-depressive-disorders
#15
Christoph Dockweiler, Anna Kupitz, Claudia Hornberg
Objectives Over the past few years, there has been a considerable increase in online-based therapeutic services for people affected by depressive disorders. The efficacy and efficiency of these programmes is well documented by now. User acceptance is considered as a significant factor of success in establishing this new patient-centered care. Theory-based acceptance surveys can provide valuable scientific knowledge regarding long-term introduction. Methods A nationwide online survey was conducted to determine the attitude towards web-based psychotherapy services for depressive disorders, the current state of knowledge and the intention of 186 participants (124 female and 62 male participants; aged 21 and above) to use these services...
November 10, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29126207/effects-of-30-and-50-cigarette-pack-graphic-warning-labels-on-visual-attention-negative-affect-quit-intentions-and-smoking-susceptibility-among-disadvantaged-populations-in-the-united-states
#16
Chris Skurka, Deena Kemp, Julie Davydova, James F Thrasher, Sahara Byrne, Amelia Greiner Safi, Rosemary J Avery, Michael C Dorf, Alan D Mathios, Leah Scolere, Jeff Niederdeppe
Introduction: Though the WHO Framework Convention for Tobacco Control (FCTC) calls for the implementation of large graphic warning labels on cigarette boxes (GWLs), the courts have blocked the implementation of 50% labels in the U.S. We conducted an experiment to explore whether changing the size of GWLs is associated with changes in visual attention, negative affect, risk beliefs, and behavioral intentions. Method: We recruited adult smokers (N = 238) and middle-school youth (N = 237) throughout New York state in May 2016...
November 4, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29125942/conditions-for-addressing-environmental-determinants-of-health-behavior-in-intersectoral-policy-networks-a-fuzzy-set-qualitative-comparative-analysis
#17
D T J M Peters, S Verweij, K Grêaux, K Stronks, J Harting
Improving health requires changes in the social, physical, economic and political determinants of health behavior. For the realization of policies that address these environmental determinants, intersectoral policy networks are considered necessary for the pooling of resources to implement different policy instruments. However, such network diversity may increase network complexity and therefore hamper network performance. Network complexity may be reduced by network management and the provision of financial resources...
September 1, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29124626/examining-delivery-method-and-infant-feeding-intentions-between-women-in-traditional-and-non-traditional-prenatal-care
#18
Deb Risisky, Ronna L Chan, Victoria A Zigmont, Syed Masood Asghar, Nancy DeGennaro
Introduction The purpose of the study is to evaluate delivery method and breastfeeding initiation in women enrolled in group prenatal care (CenteringPregnancy) and in traditional prenatal care. Methods Data were obtained from medical records of a hospital-based midwifery practice in south central Connecticut that offered both types of prenatal care programs. Medical information from 307 women enrolled in this practice was included in the analysis. Out of the 307, 80 were enrolled in group prenatal care. Socio-demographic, lifestyle, and previous and current obstetrical information from medical records formed the basis of comparison...
November 9, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29121961/a-multicomponent-intervention-for-the-management-of-chronic-pain-in-older-adults-study-protocol-for-a-randomized-controlled-trial
#19
Sheung-Tak Cheng, Ka Long Chan, Rosanna W L Lam, Monique H T Mok, Phoon Ping Chen, Yu Fat Chow, Joanne W Y Chung, Alexander C B Law, Jenny S W Lee, Edward M F Leung, Cindy W C Tam
BACKGROUND: Studies have shown that physical interventions and psychological methods based on the cognitive behavioral approach are efficacious in alleviating pain and that combining both tends to yield more benefits than either intervention alone. In view of the aging population with chronic pain and the lack of evidence-based pain management programs locally, we developed a multicomponent intervention incorporating physical exercise and cognitive behavioral techniques and examined its long-term effects against treatment as usual (i...
November 9, 2017: Trials
https://www.readbyqxmd.com/read/29121413/person-centredness-in-elder-care-a-secondary-analysis-of-data-from-a-study-among-home-dwelling-men-and-women-in-the-faroe-islands
#20
Ása Róin
AIMS AND OBJECTIVES: As individuals in Western societies age, there is increasing demand for home-based care to help older people stay in their homes for as long as possible and provide services that ensure a person's quality of life in old age. Numerous attempts are made to develop a framework to secure quality of care. However, research has shown insufficient quality in care for older people. In this paper, the purpose is to study how older people's experiences with home care reflect a person-centred approach to care...
November 9, 2017: Journal of Clinical Nursing
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