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Cardio-Renal syndrome

Cinzia Ferreri, Marzia Testa, Laura Leto, Mauro Feola
No abstract text is available yet for this article.
December 2016: Minerva Cardioangiologica
Cinzia Ferreri, Marzia Testa, Laura Leto, Mauro Feola
No abstract text is available yet for this article.
December 2016: Minerva Cardioangiologica
Francesca Saccon, Mariele Gatto, Anna Ghirardello, Luca Iaccarino, Leonardo Punzi, Andrea Doria
Galectins are evolutionary conserved β-galactoside binding proteins with a carbohydrate-recognition domain (CRD) of approximately 130 amino acids. In mammals, 15 members of the galectin family have been identified and classified into three subtypes according to CRD organization: prototype, tandem repeat-type and chimera-type galectins. Galectin-3 (gal-3) is the only chimera type galectin in vertebrates containing one CRD linked to an unusual long N-terminal domain which displays non-lectin dependent activities...
September 23, 2016: Autoimmunity Reviews
Silvia Lai, Mauro Ciccariello, Mira Dimko, Alessandro Galani, Silvio Lucci, Rosario Cianci, Amalia Mariotti
: Bakground/Aims: Cardiovascular diseases represent the leading causes of morbidity and mortality in patients with cronich kidney disease (CKD). The pathogenesis includes a complex, bidirectional interaction between heart and kidney termed cardiorenal syndrome type 4. The aim of study was to evaluate the association between renal and cardiovascular ultrasonographic parameters and identify early markers of cardiovascular risk. METHODS: A total of 35 patients with CKD and 25 healthy controls, were enrolled and we have evaluated inflammatory indexes, mineral metabolism, renal function, renal and cardiovascular ultrasonographic parameters...
September 26, 2016: Kidney & Blood Pressure Research
Joseph Gnanaraj, Jai Radhakrishnan
Cardio-renal syndrome is a commonly encountered problem in clinical practice. Its pathogenesis is not fully understood. The purpose of this article is to highlight the interaction between the cardiovascular system and the renal system and how their interaction results in the complex syndrome of cardio-renal dysfunction. Additionally, we outline the available therapeutic strategies to manage this complex syndrome.
2016: F1000Research
Joerg C Schefold, Gerasimos Filippatos, Gerd Hasenfuss, Stefan D Anker, Stephan von Haehling
Heart failure (HF) is a major health-care problem and the prognosis of affected patients is poor. HF often coexists with a number of comorbidities of which declining renal function is of particular importance. A loss of glomerular filtration rate, as in acute kidney injury (AKI) or chronic kidney disease (CKD), independently predicts mortality and accelerates the overall progression of cardiovascular disease and HF. Importantly, cardiac and renal diseases interact in a complex bidirectional and interdependent manner in both acute and chronic settings...
October 2016: Nature Reviews. Nephrology
Nir Flint, Natalia Kaufman, Amir Gal-Oz, Gilad Margolis, Yan Topilsky, Gad Keren, Yacov Shacham
OBJECTIVE: Increased transmitral flow velocity (E) to the early mitral annulus velocity (e') ratio (E/e'), signifying increased cardiac filling pressure, was previously found to be associated with deterioration of renal function in patients with congestive heart failure. No study, however, included patients with acute myocardial ischemia. We hypothesized that elevated E/e' ratio would be associated with an increased risk of acute kidney injury (AKI) in ST elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI)...
August 22, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Chet R Villa, Ahmad Kaddourah, Jacob Mathew, Thomas D Ryan, Brenda L Wong, Stuart L Goldstein, John L Jefferies
Patients with Duchenne muscular dystrophy (DMD) develop dilated cardiomyopathy and are at risk for kidney injury. Creatinine based estimated glomerular filtration rate (eGFR) is limited by low muscle mass with low serum creatinine levels in DMD. We assessed the relationship between cardiac function, modified Schwartz eGFR and cystatin C eGFR in patients with DMD. Ninety-three patients with DMD were screened for renal dysfunction in an outpatient neuromuscular clinic. Patients with new nephrotoxic medications, recent hospitalization or decompensated heart failure were excluded from the analysis...
October 2016: Neuromuscular Disorders: NMD
M Bordicchia, M Ceresiani, M Pavani, R Sarzani
OBJECTIVE: Natriuretic peptides (NP), ANP and BNP, regulate not only the homeostasis of the cardiovascular system but also lipid metabolism in adipocytes by promoting lipolysis and thermogenesis. NP circulating levels and therefore their systemic effects are largely dependent on the expression ratio between NPRA (principal biologically active receptor) and NPRC (clearance receptor). Adipocytes affect NP levels and their cardio-renal effects through the expression of NPRC. AIM: To evaluate the role of insulin and ANP on lipolysis, looking for a common mechanism underlying the metabolic syndrome and hypertension...
September 2016: Journal of Hypertension
Claire Mounier-Vehier, Anne-Laure Madika, Fanny Boudghène-Stambouli, Guillaume Ledieu, Pascal Delsart, Vassilis Tsatsaris
Preeclampsia is a specific risk factor chronic of hypertension, of coronary events (Ray et al., 2005), of stroke (Brown et al., 2006), of chronic renal failure (Kattah and Garovic, 2005; McDonald et al., 2003; Williams, 2003) and a specific risk factor of cardio-cerebrovascular mortality (Magnussen et al., 2009). According to Magnusson et al. (2009), the relative long-term risk of developing hypertension is multiplied by 4; the risk of diabetes and metabolic syndrome multiplied by 3; the risk of coronary heart disease and stroke multiplied by 2...
July 2016: La Presse Médicale
L Bozzetto, G Annuzzi, M Ragucci, O Di Donato, G Della Pepa, G Della Corte, E Griffo, G Anniballi, A Giacco, M Mancini, A A Rivellese
BACKGROUND AND AIMS: The role of the different factors associated with fatty liver is still poorly defined. We evaluated the relationships between liver fat content (LF) and metabolic, inflammatory and nutritional factors in a homogeneous cohort of individuals at high cardio-metabolic risk. METHODS AND RESULTS: In 70 individuals with high waist circumference and at least one more criterion for metabolic syndrome enrolled in a nutritional intervention study, LF was evaluated at baseline by hepatic/renal echo intensity ratio (H/R), together with dietary habits (7-day dietary record), insulin sensitivity and β-cell function (fasting and OGTT-derived indices), fasting and postprandial plasma GLP-1 and lipoproteins, and plasma inflammatory markers...
July 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M Bordicchia, M Ceresiani, M Pavani, D Minardi, M Polito, M Wabitsch, V Cannone, J C Burnett, P Dessì-Fulgheri, R Sarzani
Cardiac natriuretic peptides (NP) are involved in cardiorenal regulation and in lipolysis. The NP activity is largely dependent on the ratio between the signaling receptor NPRA and the clearance receptor NPRC. Lipolysis increases when NPRC is reduced by starving or very-low-calorie diet. On the contrary, insulin is an antilipolytic hormone that increases sodium retention, suggesting a possible functional link with NP. We examined the insulin-mediated regulation of NP receptors in differentiated human adipocytes and tested the association of NP receptor expression in visceral adipose tissue (VAT) with metabolic profiles of patients undergoing renal surgery...
July 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Tansu Sav, Faruk Cecen, Enver S Albayrka
BACKGROUND: Cardiorenal syndrome (CRS) is defined as complex pathophysiological disorder of the heart and kidneys. Both heart and renal failure are characterized by increased systemic oxidative stress in CRS. The aim of the present study is to assess the impacts of ultrafiltration (UF) and furosemide treatment on oxidative stress markers and renal functions in patients with CRS. METHOD: 77 patients with CRS (37 patients in the UF group and 40 patients in the furosemide group) were included in the study...
April 20, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
M Piastra, A Tempera, E Luca, E Buffone, C Cafforio, V Briganti, O Genovese, M Marano, D Rigante
Streptococcus pneumoniae sepsis has high morbidity, particularly if complicated by renal injury. Four patients with S. pneumonia invasive infections complicated by renal disorders are presented. The first case was an 18-month-old girl with pneumococcal empyema complicated by haemolytic uraemic (HUS) syndrome. She made a full recovery after mechanical ventilation, inotropic support and haemodiafiltration. The second was a 4-year-old boy who presented with acute post-infectious glomerulonephritis associated with bilateral pneumococcal pneumonia...
January 29, 2016: Paediatrics and International Child Health
Jianyong Yin, Zeyuan Lu, Feng Wang, Zhenzhen Jiang, Limin Lu, Naijun Miao, Niansong Wang
Chronic kidney disease is associated with higher risk of cardiovascular complication and this interaction can lead to accelerated dysfunction in both organs. Renalase, a kidney-derived cytokine, not only protects against various renal diseases but also exerts cardio-protective effects. Here, we investigated the role of renalase in the progression of cardiorenal syndrome (CRS) after subtotal nephrectomy. Sprague-Dawley rats were randomly subjected to sham operation or subtotal (5/6) nephrectomy (STNx). Two weeks after surgery, sham rats were intravenously injected with Hanks' balanced salt solution (sham), and STNx rats were randomly intravenously injected with adenovirus-β-gal (STNx+Ad-β-gal) or adenovirus-renalase (STNx+Ad-renalase) respectively...
June 2016: Journal of Cellular and Molecular Medicine
D Batouche, M A Djazouli, L Sadaoui, W Berrached, N Benatta
OBJECTIFS: La cardiomyopathie idiopathique du péripartum (CIPP) est une affection rare de cause inconnue, dont l'évolution est grevée par de nombreuses complications hémodynamiques, thrombo - emboliques et rythmiques. L'objectif de ce travail rétrospectif est de décrire les aspects cliniques, paracliniques, évolutifs. MéTHODES: Nous avons mené une étude dans le Service de Gynécologie du CHU d'Oran, portant sur 12 patientes atteintes de CIPP, de septembre 2010 à septembre 2014...
December 2015: Annales de Cardiologie et D'angéiologie
I V Khomyak, O V Rotar, V I Rotar, G G Petrovskiy
There were examined 113 patients, in whom an acute necrotic pancreatitis was diagnosed. While admittance to hospital a constant organ insufficiency was revealed in 50 (44%), a transient one--in 63 (56%) patients. In total 31 (27.4%) patients died. Respiratory insufficiency have occurred in 67% patients, and almost with similar rate--cardio-vascular (in 59%), renal (in 56%) and enteral (in 54%), dominating in the lethality structure. The BISAP (Bedcide Index for Severity in Acute Pancreatitis) scales applied permit with high probability to prognosticate the organ insufficiency and lethality in patients, suffering an acute necrotic pancreatitis...
September 2015: Klinichna Khirurhiia
Frederik H Verbrugge, Wilfried Mullens, W H Wilson Tang
Diuretic resistance in acute heart failure has emerged as a powerful predictor of adverse outcome, which is often independent of underlying glomerular filtration rate (GFR). Metrics of diuretic efficacy differ in their accuracy, convenience, and biological plausibility, which should be taken into account when interpreting their results. Loop diuretic efficacy depends on adequate delivery of both the pharmacological agent itself and its substrate (i.e., sodium chloride) to the loop diuretic site of action at the luminal side of the thick ascending limb of Henle's loop...
February 2016: Current Treatment Options in Cardiovascular Medicine
Wen-Chih Liu, Chia-Chao Wu, Yao-Min Hung, Min-Tser Liao, Jia-Fwu Shyu, Yuh-Feng Lin, Kuo-Cheng Lu, Kun-Chieh Yeh
Low 25(OH)D levels are common in chronic kidney disease (CKD) patients and are implicated in all-cause mortality and morbidity risks. Furthermore, the progression of CKD is accompanied by a gradual decline in 25(OH)D production. Vitamin D deficiency in CKD causes skeletal disorders, such as osteoblast or osteoclast cell defects, bone turnover imbalance, and deterioration of bone quality, and nonskeletal disorders, such as metabolic syndrome, hypertension, immune dysfunction, hyperlipidemia, diabetes, and anemia...
January 30, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Udipi Badikillaya Vijayalakshmi, Manasa Rayidi
INTRODUCTION: The global prevalence of chronic kidney disease (CKD) is estimated to be 8-16%. Studies have shown that the increased mortality in patients with CKD is due to anemia that leads to cardiovascular disease (CVD), also known as "Cardio renal anemia syndrome". The present study was undertaken to look into the laboratory profiles of end stage renal disease (ESRD) patients. AIM: To study the laboratory profiles of End stage renal disease (ESRD) patients coming for hemodialysis...
October 2015: Journal of Clinical and Diagnostic Research: JCDR
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