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Juhani Määttä, Hannu Kautiainen, Ville Leinonen, Jaakko Niinimäki, Salme Järvenpää, Tatu Koskelainen, Pirkka Mäkelä, Juha Pesälä, Timo Nyyssönen, Sakari Savolainen, Olavi Airaksinen, Eero Kyllönen, Kenneth M C Cheung, Jaro Karppinen
Background and purpose Modic changes (MC) are bone marrow and vertebral endplate lesions seen in magnetic resonance imaging (MRI) which have been found to be associated with low back pain (LBP), but the association between MC and health-related quality of life (HRQoL) is poorly understood. The aim of this study was to assess the relationship between MC and HRQoL among patients referred to spine surgery. Methods The study population consisted of 181 patients referred to lumbar spine surgery in Northern and Eastern Finland between June 2007 and January 2011...
December 29, 2017: Scandinavian Journal of Pain
Lunhao Chen, Xiaojian Hu, Jingfeng Zhang, Michele C Battié, Xiangjin Lin, Yue Wang
STUDY DESIGN: This is a cross-sectional study. OBJECTIVE: To determine the prevalence and distribution patterns of Modic changes (MCs) in the lumbar spine and their associations with disk degeneration in mainland Chinese using a sample of general population. SUMMARY OF BACKGROUND DATA: Previous studies reported that the prevalence of MCs in Hong Kong Chinese was much lower than in other populations. Moreover, their associations with disk degeneration need further study...
May 25, 2018: Clinical Spine Surgery
Sabrina Munir, Maxim B Freidin, Marinko Rade, Juhani Määttä, Gregory Livshits, Frances M K Williams
STUDY DESIGN: Longitudinal study of spine magnetic resonance imaging (MRI) in a large-scale population-based study. OBJECTIVE: To determine the order of appearance of degenerative change in vertebral bodies and intervertebral discs. We also sought to define the influence of endplate defect on low back pain (LBP) and to determine whether there is a genetic influence on endplate defect. SUMMARY OF BACKGROUND DATA: Endplate defect is a magnetic resonance imaging trait, found to be associated with intervertebral disc degeneration...
May 25, 2018: Spine
Håvard Furunes, Christian Hellum, Ansgar Espeland, Jens Ivar Brox, Milada Cvancarova Småstuen, Linda Berg, Kjersti Storheim
STUDY DESIGN: Randomized controlled multicenter trial with eight-year follow-up. OBJECTIVE: To assess the long-term development of adjacent disc degeneration (ADD) after lumbar total disc replacement (TDR) or non-operative treatment, and to analyze the association between ADD development and clinical outcome. SUMMARY OF BACKGROUND DATA: TDR was introduced as a motion-preserving alternative to spinal fusion, which has been reported to increase the risk of ADD...
May 22, 2018: Spine
Weiwei Xia, Chenjun Liu, Shuo Duan, Shuai Xu, Kaifeng Wang, Zhenqi Zhu, Haiying Liu
BACKGROUND: The typical degeneration of the vertebral endplate shown in MRI imaging is Modic change. The aim of this study was to observe the distribution of the Modic changes of vertebral endplate in degenerative thoracolumbar/lumbar kyphosis (DTK/LK) patients and analyse the correlation between spinal-pelvic parameters and Modic changes. METHODS: The imaging data of 58 patients diagnosed with DTK/LK (coronal Cobb angle<10°with sagittal imbalance) in our hospital from March 2016 to May 2017 were reviewed retrospectively...
2018: PloS One
Shu Nakamura, Mitsuto Taguchi
Study Design: Retrospective clinical study. Purpose: This study investigated the relationship between surgical approaches and surgical outcomes in patients undergoing percutaneous endoscopic cervical discectomy (PECD), including the reduction in intervertebral disc height and the incidence of Modic changes. Overview of Literature: The anterior approach involves partial invasion of the intervertebral disc, with a reported reduction in intervertebral disc height after PECD...
April 2018: Asian Spine Journal
Yilei Chen, Xianjun Wang, Xuyang Zhang, Hong Ren, Bao Huang, Jian Chen, Junhui Liu, Zhi Shan, Zhihai Zhu, Fengdong Zhao
STUDY DESIGN: A prospective cross-sectional case series study. OBJECTIVE: To investigate the prevalence of low virulence disc infection and its associations with characteristics of patients or discs in the cervical spine. BACKGROUND: Low virulence bacterial infections could be a possible cause of intervertebral disc degeneration and/or back pain. Controversies are continuing over whether these bacteria, predominantly Propionibacterium acnes (P...
April 19, 2018: European Spine Journal
Pan Qiao, Tian-Tong Xu, Wen Zhang, Rong Tian
BACKGROUND: The distribution and related factors of Modic changes (MC) in the lumbar spine has been evaluated. In the present study, the MC in the cervical endplate of patients with cervical spondylotic myelopathy (CSM) was investigated. METHODS: A total of 6422 cervical endplates of 539 patients suffered from CSM (259 males and 280 females) with mean age of 46 ± 5.2 years. All patients underwent MRI scans and X-ray for evaluating the distribution of MC. The clinical information were recorded...
April 18, 2018: Journal of Orthopaedic Surgery and Research
Kenichi Kawaguchi, Katsumi Harimaya, Yoshihiro Matsumoto, Mitsumasa Hayashida, Seiji Okada, Keiichiro Iida, Go Kato, Kuniyoshi Tsuchiya, Toshio Doi, Yoshinao Oda, Yukihide Iwamoto, Yasuharu Nakashima
OBJECTIVE: The aim of this study was to investigate the clinicopathologic features of lumbar disc herniation (LDH) with endplate degeneration and the association between cartilaginous fragments and inflammatory response to the herniated disc. SUMMARY OF BACKGROUND DATA: LDH often involves hyaline cartilage fragments pulled from the vertebral endplates. Modic changes are closely associated with LDH that contains hyaline cartilage, and cartilaginous endplates seem to affect resorption of the herniated disc...
2018: PloS One
Xianda Gao, Jia Li, Yiqing Shi, Shaoqing Li, Yong Shen
BACKGROUND: The current study aimed to discuss the prevalence and surgical outcomes of the asymmetrical Modic changes and identify its correlative factors by multivariate logistic regression analysis. METHODS: Two hundred seventy-eight patients with single-level Modic changes and nerve compression symptoms were reviewed retrospectively from January 2008 to January 2015. 1.5-T MRI was performed to determine the Modic changes. Multivariate logistic regression analysis was used to identify the correlative factors of asymmetrical Modic changes...
April 16, 2018: Journal of Orthopaedic Surgery and Research
L M Romero-Muñoz, A Barriga-Martín, A Segura-Fragoso, C Martín-González
OBJECTIVE: Establish the long-term (10 years) predictive value of Modic changes in the course of lumbar pain and the need for surgical treatment. MATERIAL AND METHOD: Observational longitudinal prospective cohort study. Comparison of progression at 10 years of 2 groups of patients with chronic lumbar pain: group A with Modic changes in MRI and group B with no Modic changes. EXCLUSION CRITERIA: neoplasia, inflammatory or infectious diseases, or previous surgery...
March 31, 2018: Revista Española de Cirugía Ortopédica y Traumatología
Fan Zhang, Hongli Wang, Haocheng Xu, Minghao Shao, Feizhou Lu, Jianyuan Jiang, Xiaosheng Ma, Xinlei Xia
OBJECTIVE: The kinematic characteristics of Modic changes (MCs) in the lumbar spine have rarely been reported; furthermore, the effect of disc degeneration (DD) on segmental motion has not been considered in analyzing the motion characteristics of MCs. Therefore, this study was designed to evaluate the kinematic characteristics of MCs based on different DD grades. METHODS: 894 patients with 4470 lumbar segments were reviewed, and those with MCs were selected for segmental motion evaluation...
June 2018: World Neurosurgery
Jiangbo Bai, Kunlun Yu, Yaning Sun, Lingde Kong, Yong Shen
Background: The aim of this study was to assess the prevalence of cervical Modic change (MC) in patients with cervical spondylosis and to develop a better understanding of the possible risk factors for the prevalence of MC. Methods: Between January 2014 and April 2017, patients with cervical spondylosis were included in our study. All patients underwent magnetic resonance imaging (MRI) to evaluate the presence of MC. The MC was classified into three types according to the Modic classification...
2018: Journal of Pain Research
Rikke K Jensen, Peter Kent, Tue S Jensen, Per Kjaer
BACKGROUND: Research into the clinical importance of spinal MRI findings in patients with low back pain (LBP) has primarily focused on single imaging findings, such as Modic changes or disc degeneration, and found only weak associations with the presence of pain. However, numerous MRI findings almost always co-exist in the lumbar spine and are often present at more than one lumbar level. It is possible that multiple MRI findings are more strongly associated with LBP than single MRI findings...
February 20, 2018: BMC Musculoskeletal Disorders
Jeffrey S Fischgrund, A Rhyne, J Franke, R Sasso, S Kitchel, H Bae, C Yeung, E Truumees, M Schaufele, P Yuan, P Vajkoczy, M DePalma, D G Anderson, L Thibodeau, B Meyer
PURPOSE: To evaluate the safety and efficacy of radiofrequency (RF) ablation of the basivertebral nerve (BVN) for the treatment of chronic low back pain (CLBP) in a Food and Drug Administration approved Investigational Device Exemption trial. The BVN has been shown to innervate endplate nociceptors which are thought to be a source of CLBP. METHODS: A total of 225 patients diagnosed with CLBP were randomized to either a sham (78 patients) or treatment (147 patients) intervention...
February 8, 2018: European Spine Journal
Koji Tamai, Jessica Chen, Michael Stone, Anush Arakelyan, Permsak Paholpak, Hiroaki Nakamura, Zorica Buser, Jeffrey C Wang
PURPOSE: The cross-sectional area and fat infiltration are accepted as standard parameters for quantitative and qualitative evaluation of muscle degeneration. However, they are time-consuming, which prevents them from being used in a clinical setting. The aim of this study was to analyze the relationship between lumbar muscle degeneration and spinal degenerative disorders, using lumbar indentation value (LIV) as quantitative and Goutallier classification as qualitative measures. METHODS: This is a retrospective analysis of kinematic magnetic resonance images (kMRI)...
May 2018: European Spine Journal
Hanna Hebelka, Andreia Miron, Izabela Kasperska, Helena Brisby, Kerstin Lagerstrand
BACKGROUND: The function of the endplate (EP) is the most important factor influencing nutritional supply to the avascular intervertebral disc (IVD). It is desired to have a non-invasive method to assess functional EP characteristics in vivo. Assessment of functional EP characteristics is important in order to understand its relation to IVD degeneration, which in turn might deepen the understanding of the pathophysiology behind low back pain (LBP). It was hypothesized that, by comparing quantitative MRI of EPs performed with conventional supine MRI (unloaded MRI) with axial loading during MRI (alMRI), dynamical properties of the EP can be displayed...
January 30, 2018: Journal of Orthopaedic Surgery and Research
Koji Tamai, Joshua Romanu, Phillip Grisdela, Permsak Paholpak, Pengfei Zheng, Hiroaki Nakamura, Zorica Buser, Jeffrey C Wang
BACKGROUND CONTEXT: Cervical sagittal vertical axis (cSVA) of ≥40 mm is recognized as the key factor of poor health-related quality of life, poor surgical outcomes, and correction loss after surgery for cervical deformity. However, little is known about the radiological characteristics of patients with cSVA≥40 mm. PURPOSE: The purpose of this study was to identify the radiological characteristics of patients with cervical imbalance. DESIGN: Retrospective analysis of weight-bearing cervical magnetic resonance (MR) images...
January 31, 2018: Spine Journal: Official Journal of the North American Spine Society
Guoqi Cai, Laura L Laslett, Dawn Aitken, Andrew Halliday, Feng Pan, Petr Otahal, Deborah Speden, Tania M Winzenberg, Graeme Jones
The aim of this study was to evaluate the effect of zoledronic acid (ZA) and denosumab on low back pain (LBP) and Modic change (MC) over 6 months. Adults aged ≥40 years with significant LBP for at least 6 months duration and MC (type 1, 2, or mixed) were randomized to receive ZA (5 mg/100 mL), denosumab (60 mg), or placebo. LBP was measured monthly by visual analogue scale (VAS) and the LBP Rating Scale (RS). MC was measured from MRIs of T12 -S1 vertebrae at screening and 6 months. A total of 103 participants with moderate/severe LBP (mean VAS = 57 mm; mean RS = 18) and median total MC area 538 mm2 were enrolled...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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