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https://www.readbyqxmd.com/read/28431955/the-course-of-modic-vertebral-body-changes-after-posterolateral-lumbar-fusion-on-fused-and-adjacent-levels-a-systematic-review-of-the-literature
#1
REVIEW
Stella Taylor Portella, Marcus André Acioly
According to the original description by Modic et al., the natural course of bone marrow signal abnormalities is an inexorable, progressive one, however recent evidence has demonstrated in healthy individuals and those suffering from lumbar disc herniation that the course of endplate degenerative changes is rather dynamic and sometimes regressive. The evolution of such changes in lumbar fused segments and adjacent levels is largely unknown. The literature relevant to the course of Modic changes on fused and adjacent levels, as well as its clinical correspondence in patients undergoing posterolateral lumbar fusion was collected...
April 18, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28421295/do-modic-changes-affect-cervical-sagittal-alignment-and-motion-in-symptomatic-patients
#2
Tong Tong, Xian-Da Gao, Jia Li, Jing-Tao Zhang, Rui-Jie Niu, Zhao Liu, Yong Shen
PURPOSE: The cervical segmental instability often occurs simultaneously with Modic changes (MCs). However, it is unknown whether there is a relation between the two diseases. The aim of this study was to evaluate the relationship between MCs and cervical segmental instability, cervical curvature and range of motion (ROM) in the cervical spine. METHODS: A total of 464 patients with neck pain or cervical neurologic symptoms who underwent imaging examination were analyzed retrospectively...
April 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28402320/prevalence-of-modic-changes-in-the-lumbar-vertebrae-and-their-associations-with-workload-smoking-and-weight-in-northern-china
#3
Chao Han, Ming-Jie Kuang, Jian-Xiong Ma, Xin-Long Ma
The distribution of Modic changes (MCs) in the lumbar endplates and the evaluation of the relationships between MCs and risk factors are vital for research into MCs. The T1-weighted and T2-weighted sagittal MRI scans of 210 patients who exhibited lumbar intervertebral disc degeneration were retrospectively reviewed. The patients' weights, genders, smoking statuses, physical activity levels and specific types of MC were recorded. The associations between MCs and risk factors, such as physical work, smoking and body mass index, were also analysed...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28399545/propionibacterium-acnes-incubation-in-the-discs-can-result-in-time-dependent-modic-changes-a-long-term-rabbit-model
#4
Zhi Shan, Xuyang Zhang, Shengyun Li, Tianming Yu, Junhui Liu, Fengdong Zhao
STUDY DESIGN: A case control study of animal model of Modic changes (MCs) on Rabbits. OBJECTIVE: To evaluate the feasibility of inducing of MCs by injection of Propionibacterium acne (P. acnes) into the lumbar intervertebral discs of rabbits. SUMMARY OF BACKGROUND DATA: MCs have been widely observed, and assume to be closely associated with low back pain and P. acnes, but there are few animal models showing the progression of MCs. METHODS: Ten rabbits were used for the study...
April 10, 2017: Spine
https://www.readbyqxmd.com/read/28394776/correlation-analysis-between-modic-change-of-cervical-vertebrae-and-intramedullary-high-signal-intensity
#5
Hao Zhou, Jin Fan, Peng Sun, Wei Zhou, Qingqing Li, Lipeng Yu, Guoyong Yin
PURPOSE: Clinical studies have shown that endplate Modic change in the cervical spine and intramedullary high signal intensity often occurs simultaneously. We aimed to investigate whether there is a correlation between Modic change and intramedullary high signal intensity, and to explore the possible risk factors. MATERIALS AND METHODS: In total, 133 patients with cervical spondylotic myelopathy treated at the First Affiliated Hospital of Nanjing Medical University between May 2009 and March 2013 were enrolled in the study...
April 7, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28377243/hybrid-bone-spect-ct-imaging-in-evaluation-of-chronic-low-back-pain-correlation-with-modic-changes-and-degenerative-disc-disease
#6
Vittorio M Russo, Ranju T Dhawan, Nishanth Dharmarajah, I Baudracco, Antonio I Lazzarino, Adrian T Casey
BACKGROUND CONTEXT: Multiple radiological modalities are used in the evaluation of patients with low back pain (LBP). Only limited evidence currently exists to support the use of Bone HDP (hydroxydiphosphonate) SPECT/CT (Single Photon Emission Computed Tomography) in patients with Modic changes (MC) and degenerative disc disease (DDD). PURPOSE: The aim of this study was to assess the value of the hybrid Bone SPECT/CT imaging in patients with chronic low back pain...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28291179/the-influence-of-direct-inoculation-of-propionibacterium-acnes-on-modic-changes-in-the-spine-evidence-from-a-rabbit-model
#7
Zhi Shan, Xuyang Zhang, Shengyun Li, Tianming Yu, Maiwulanjiang Mamuti, Fengdong Zhao
BACKGROUND: Modic changes (inflammatory-like changes visible on magnetic resonance imaging [MRI] scans of a vertebral end plate) are common and are associated with low back pain, but their origin is unclear. To our knowledge, there have been no previous in vivo animal models of Modic changes. We hypothesized that Modic changes may be related to Propionibacterium acnes. METHODS: Ten New Zealand White rabbits were injected percutaneously with 1 mL of P. acnes (1.6 × 10 colony forming units/mL) into the subchondral bone superior to the L4-L5 and L5-L6 discs; 10 other control rabbits received sham injections at L4-L5 and 1 mL of normal saline solution (vehicle) at L5-L6...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28206726/are-modic-type-2-disc-changes-associated-with-low-grade-infections-a-pilot-study
#8
Lorenzo Drago, Carlo L Romanò, Riccardo Cecchinato, Jorge H Villafañe, Elena De Vecchi, Claudio Lamartina, Pedro Berjano
BACKGROUND: The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs. The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs. METHODS: Sixteen patients with Modic 2 changes were compared with 23 patients without Modic signs...
February 15, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28168339/automation-of-reading-of-radiological-features-from-magnetic-resonance-images-mris-of-the-lumbar-spine-without-human-intervention-is-comparable-with-an-expert-radiologist
#9
Amir Jamaludin, Meelis Lootus, Timor Kadir, Andrew Zisserman, Jill Urban, Michele C Battié, Jeremy Fairbank, Iain McCall
STUDY DESIGN: Investigation of the automation of radiological features from magnetic resonance images (MRIs) of the lumbar spine. OBJECTIVE: To automate the process of grading lumbar intervertebral discs and vertebral bodies from MRIs. MR imaging is the most common imaging technique used in investigating low back pain (LBP). Various features of degradation, based on MRIs, are commonly recorded and graded, e.g., Modic change and Pfirrmann grading of intervertebral discs...
February 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28158154/percutaneous-vertebroplasty-for-symptomatic-schmorl-s-nodes-11-cases-with-long-term-follow-up-and-a-literature-review
#10
Shi-Cheng He, Bin-Yan Zhong, Hai-Dong Zhu, Wen Fang, Li Chen, Jin-He Guo, Gang Deng, Gao-Jun Teng
BACKGROUND: Percutaneous vertebroplasty (PVP) is commonly used to treat symptomatic vertebral compression fractures. However, its long-term effectiveness and safety for use in the treatment of symptomatic Schmorl's nodes (SNs) refractory to conservative treatment is uncertain. OBJECTIVES: To present a case series with PVP for symptomatic SNs not responding to conservative therapy and assess the effectiveness and safety for such treatment with long-term follow-up...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28150049/expert-s-comment-concerning-grand-rounds-case-entitled-rehydration-of-a-degenerated-disc-on-mri-synchronized-with-transition-of-modic-changes-following-stand-alone-xlif-by-k-kita-t-sakai-m-abe-y-takata-and-k-sairyo-eur-spine-j-2017-doi-10-1007-s00586-017-4945
#11
https://www.readbyqxmd.com/read/28144734/rehydration-of-a-degenerated-disc-on-mri-synchronized-with-transition-of-modic-changes-following-stand-alone-xlif
#12
Kenichiro Kita, Toshinori Sakai, Mitsunobu Abe, Yoichiro Takata, Koichi Sairyo
Lumbar intervertebral disc degeneration (LDD) is known to be associated with low back pain (LBP) and leads to degenerative lumbar disease. LDD is considered to be irreversible, and no truly effective treatment that suppresses LDD or regenerates the degenerated disc has been established thus far. Here, we report the case of a 42-year-old woman with a 10-year history of persistent LBP. Magnetic resonance imaging (MRI) demonstrated degenerative changes (Pfirrmann classification: grade IV) in the L4-5 intervertebral disc with type I and III mixed Modic changes adjacent to the disc...
January 31, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28138783/intervertebral-disc-bone-marrow-cross-talk-with-modic-changes
#13
Stefan Dudli, David C Sing, Serena S Hu, Sigurd H Berven, Shane Burch, Vedat Deviren, Ivan Cheng, Bobby K B Tay, Todd F Alamin, Ma Agnes Martinez Ith, Eric M Pietras, Jeffrey C Lotz
STUDY DESIGN: Cross-sectional cohort analysis of patients with Modic Changes (MC). OBJECTIVE: Our goal was to characterize the molecular and cellular features of MC bone marrow and adjacent discs. We hypothesized that MC associate with biologic cross-talk between discs and bone marrow, the presence of which may have both diagnostic and therapeutic implications. BACKGROUND DATA: MC are vertebral bone marrow lesions that can be a diagnostic indicator for discogenic low back pain...
January 31, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28127375/predictors-of-reoperation-after-microdecompression-in-lumbar-spinal-stenosis
#14
Hee-Jong Hwang, Hyung-Ki Park, Gwang-Soo Lee, June-Young Heo, Jae-Chil Chang
OBJECTIVE: The risk factors of reoperation after microdecompression (MD) for lumbar spinal stenosis (LSS) are unclear. In this study, we presented the outcomes of MD for degenerative LSS and investigated the risk factors associated with reoperation. METHODS: A retrospective review was conducted using the clinical records and radiographs of patients with LSS who underwent MD. For clinical evaluation, we used the Japanese Orthopedic Association (JOA) scoring system for low back pain, body mass index, and Charlson comorbidity index...
December 2016: Korean Journal of Spine
https://www.readbyqxmd.com/read/28081267/single-nucleotide-variants-of-candidate-genes-in-aggrecan-metabolic-pathway-are-associated-with-lumbar-disc-degeneration-and-modic-changes
#15
Romain Shanil Perera, Poruwalage Harsha Dissanayake, Upul Senarath, Lalith Sirimevan Wijayaratne, Aranjan Lional Karunanayake, Vajira Harshadeva Weerabaddana Dissanayake
INTRODUCTION: Lumbar disc degeneration (LDD) is genetically determined and severity of LDD is associated with Modic changes. Aggrecan is a major proteoglycan in the intervertebral disc and end plate. Progressive reduction of aggrecan is a main feature of LDD and Modic changes. OBJECTIVES: The study investigated the associations of single nucleotide variants (SNVs) of candidate genes in the aggrecan metabolic pathway with the severity of LDD and Modic changes. In-silico functional analysis of significant SNVs was also assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28043884/risk-factors-for-the-recurrent-herniation-after-percutaneous-endoscopic-lumbar-discectomy
#16
Yuan Yao, Huan Liu, Huiyu Zhang, Honggang Wang, Chao Zhang, Zhengfeng Zhang, Junlong Wu, Yu Tang, Yue Zhou
BACKGROUND: Percutaneous endoscopic lumbar discectomy (PELD) has been widely used for treating lumbar disc herniation (LDH). Recurrence after PELD has been reported, but few studies have focused on the risk factors responsible for PELD recurrence. METHODS: From March 2005 to March 2016, 116 patients suffering from recurrent herniation after successful PELD were enrolled in this retrospective study. Kaplan-Meier methods and Cox regression analysis were employed to identify the significant risk factors predicting PELD recurrence...
December 30, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28031964/10-years-of-research-from-ignoring-modic-changes-to-considerations-regarding-treatment-and-prevention-of-low-grade-disc-infections
#17
EDITORIAL
Claus Manniche, Alan Jordan
No abstract text is available yet for this article.
June 2016: Future Science OA
https://www.readbyqxmd.com/read/27997510/a-whole-exome-study-identifies-novel-candidate-genes-for-vertebral-bone-marrow-signal-changes-modic-changes
#18
Minna Kraatari, Sini Skarp, Niinimäki Jaakko, Jaro Karppinen, Minna Männikkö
STUDY DESIGN: Family-based study OBJECTIVE.: To identify rare genetic factors predisposing to Modic changes (MC). SUMMARY OF BACKGROUND DATA: Lumbar disc degeneration (LDD) is one of the contributing factors behind low back pain (LBP). Lumbar MC visualized as bone marrow signal intensity changes on magnetic resonance imaging (MRI) represent a specific phenotype of LDD, which has stronger association with LBP than LDD without MC. METHODS: The study set consisted of two Finnish families: Family I included seven affected and four unaffected individuals and Family II eight affected and seven unaffected individuals...
December 16, 2016: Spine
https://www.readbyqxmd.com/read/27917347/identification-of-lumbar-disc-disease-hallmarks-a-large-cross-sectional-study
#19
Jun Zhang, Fei Zhao, Feng-Liang Wang, Yong-Feng Yang, Chen Zhang, Yue Cao, You-Lin Wang, Xiao-Juan Shi, Yi Wan, Min Zhang, Meng-Qiao Liu, Chun-Guang Zuo, Hai-Qiang Wang
BACKGROUND: Lumbar disc disease has a disabling impact on global people with heavy burden on society, mainly consisting of lumbar disc degeneration (LDD) and lumbar disc herniation (LDH). The recently released lumbar disc nomenclature version 2.0 deepens our understandings on the diseases. Consequently, there is an urgent need to clarify the occurrence and distribution features of LDD and LDH in a large-scale sample in terms of the novel version. QUESTION/PURPOSES: We asked: (1) Is there a difference in the occurrence and distribution hallmarks of LDD and LDH in a population-based large-scale sample? (2) Does the novel nomenclature version bring novel vision on lumbar disc disease? METHODS: Five thousand two hundred eighty-eight consecutive cases (26,440 lumbar discs) undergoing lumbar spine MRI were retrospectively included from Jan 2008 to Dec 2010 in a territory university hospital...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27885471/modic-changes-in-the-adjacent-vertebrae-due-to-disc-material-infection-with-propionibacterium-acnes-in-patients-with-lumbar-disc-herniation
#20
Javad Aghazadeh, Firooz Salehpour, Ehsan Ziaeii, Naghme Javanshir, Afshin Samadi, Javid Sadeghi, Farhad Mirzaei, Seyed Ahmad Naseri Alavi
INTRODUCTION: Modic changes (MCs) in vertebral bones are induced by two mechanisms of mechanical factors and infection. As Propionibacterium acnes (P. acnes) have been reported to be associated with LBP. The aim of this study is to evaluate the MCs in patients with disc herniation and positive for P. acnes. METHODS AND MATERIAL: A total of 120 patients with disc herniation surgery were enrolled into the study. The samples were excised during discectomy and then cultured in both anaerobic and aerobic incubations...
November 24, 2016: European Spine Journal
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