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https://www.readbyqxmd.com/read/29423885/intraosseous-basivertebral-nerve-ablation-for-the-treatment-of-chronic-low-back-pain-a-prospective-randomized-double-blind-sham-controlled-multi-center-study
#1
Jeffrey S Fischgrund, A Rhyne, J Franke, R Sasso, S Kitchel, H Bae, C Yeung, E Truumees, M Schaufele, P Yuan, P Vajkoczy, M DePalma, D G Anderson, L Thibodeau, B Meyer
PURPOSE: To evaluate the safety and efficacy of radiofrequency (RF) ablation of the basivertebral nerve (BVN) for the treatment of chronic low back pain (CLBP) in a Food and Drug Administration approved Investigational Device Exemption trial. The BVN has been shown to innervate endplate nociceptors which are thought to be a source of CLBP. METHODS: A total of 225 patients diagnosed with CLBP were randomized to either a sham (78 patients) or treatment (147 patients) intervention...
February 8, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29396765/the-evaluation-of-lumbar-paraspinal-muscle-quantity-and-quality-using-the-goutallier-classification-and-lumbar-indentation-value
#2
Koji Tamai, Jessica Chen, Michael Stone, Anush Arakelyan, Permsak Paholpak, Hiroaki Nakamura, Zorica Buser, Jeffrey C Wang
PURPOSE: The cross-sectional area and fat infiltration are accepted as standard parameters for quantitative and qualitative evaluation of muscle degeneration. However, they are time-consuming, which prevents them from being used in a clinical setting. The aim of this study was to analyze the relationship between lumbar muscle degeneration and spinal degenerative disorders, using lumbar indentation value (LIV) as quantitative and Goutallier classification as qualitative measures. METHODS: This is a retrospective analysis of kinematic magnetic resonance images (kMRI)...
February 2, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29378613/axial-loading-during-mri-induces-significant-t2-value-changes-in-vertebral-endplates-a-feasibility-study-on-patients-with-low-back-pain
#3
Hanna Hebelka, Andreia Miron, Izabela Kasperska, Helena Brisby, Kerstin Lagerstrand
BACKGROUND: The function of the endplate (EP) is the most important factor influencing nutritional supply to the avascular intervertebral disc (IVD). It is desired to have a non-invasive method to assess functional EP characteristics in vivo. Assessment of functional EP characteristics is important in order to understand its relation to IVD degeneration, which in turn might deepen the understanding of the pathophysiology behind low back pain (LBP). It was hypothesized that, by comparing quantitative MRI of EPs performed with conventional supine MRI (unloaded MRI) with axial loading during MRI (alMRI), dynamical properties of the EP can be displayed...
January 30, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29355790/small-c7-t1-lordotic-angle-and-muscle-degeneration-at-c7-level-were-independent-radiological-characteristics-of-patients-with-cervical-imbalance-a-propensity-score-matched-analysis
#4
Koji Tamai, Joshua Romanu, Phillip Grisdela, Permsak Paholpak, Pengfei Zheng, Hiroaki Nakamura, Zorica Buser, Jeffrey C Wang
BACKGROUND CONTEXT: Cervical sagittal vertical axis (cSVA) of ≥40mm is recognized as the key factor of poor health-related quality of life, poor surgical outcomes, and correction loss after surgery for cervical deformity. However, little is known about the radiological characteristics of patients with cSVA≥40mm. PURPOSE: The purpose of this study was to identify the radiological characteristics of patients with cervical imbalance. DESIGN: Retrospective analysis of weight-bearing cervical magnetic resonance (MR) images PATIENT SAMPLE: Consecutive 1,500 MR images of symptomatic patients in weight-bearing position OUTCOME MEASURES: cSVA, cervical alignment, cervical balance parameters (T1 slope, Co-C2 angle, C2-C7 angle, C7-T1 angle, neck tilt and thoracic inlet angle), disc degeneration (Pfirmann and Suzuki classification), endplate degeneration (Modic change), Spondylolisthesis (antero- and retrolisthesis), antero-posterior (AP) diameter of dural sac, cross-sectional area (CSA) and fat infiltration ratio of the transversospinalis muscles at C4 and C7 levels METHODS: Patients were divided into two groups: cervical sagittal vertical axis (cSVA) ≥40mm and <40mm...
January 17, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29297602/effect-of-zoledronic-acid-and-denosumab-in-patients-with-low-back-pain-and-modic-change-a-proof-of-principle-trial
#5
Guoqi Cai, Laura L Laslett, Dawn Aitken, Andrew Halliday, Feng Pan, Petr Otahal, Deborah Speden, Tania M Winzenberg, Graeme Jones
The aim of this study was to evaluate the effect of zoledronic acid (ZA) and denosumab on low back pain (LBP) and Modic change (MC) over 6 months. Adults aged ≥40 years with significant LBP for at least 6 months duration and MC (type 1, 2 or mixed) were randomised to receive ZA (5mg/100ml), denosumab (60mg), or placebo. LBP was measured monthly by Visual Analogue Scale (VAS) and the LBP Rating Scale (RS). MC was measured from MRIs of T12-S1 vertebrae at screening and 6 months. 103 participants with moderate/severe LBP (mean VAS=57mm, mean RS=18) and median total MC area 538 mm2 , were enrolled...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29279162/do-modic-changes-disc-degeneration-translation-and-angular-motion-affect-facet-osteoarthritis-of-the-lumbar-spine
#6
Permsak Paholpak, Emin Dedeogullari, Christopher Lee, Koji Tamai, Kaku Barkoh, Kittipong Sessumpun, Jeffrey C Wang, Zorica Buser
The objective of the study is to identified the correlation between Modic changes (MCs), disc degeneration, motions (translation and angulation) and facet osteoarthritis in lumbar spine. 425 patients who underwent multi-positional lumbar MRI were reviewed. A total of 2250 lumbar spinal segments in neutral position were evaluated for MCs, disc degeneration grading, translation and angulation motion, and facet osteoarthritis. The chi-square test, Kruskal-Wallis, Mann-Whitney U test, Pearson's correlation and linear regression were used to test for statistically significant difference between parameters...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29246188/antibiotic-treatment-in-patients-with-chronic-low-back-pain-and-modic-changes-the-aim-study-study-protocol-for-a-randomised-controlled-trial
#7
Kjersti Storheim, Ansgar Espeland, Lars Grøvle, Jan Sture Skouen, Jörg Aßmus, Audny Anke, Anne Froholdt, Linda M Pedersen, Anne Julsrud Haugen, Terese Fors, Elina Schistad, Olav Lutro, Gunn Hege Marchand, Thomas Kadar, Nils Vetti, Sigrun Randen, Øystein Petter Nygaard, Jens Ivar Brox, Margreth Grotle, John-Anker Zwart
BACKGROUND: A previous randomised controlled trial (RCT) of patients with chronic low back pain (LBP) and vertebral bone marrow (Modic) changes (MCs) on magnetic resonance imaging (MRI), reported that a 3-month, high-dose course of antibiotics had a better effect than placebo at 12 months' follow-up. The present study examines the effects of antibiotic treatment in chronic LBP patients with MCs at the level of a lumbar disc herniation, similar to the previous study. It also aims to assess the cost-effectiveness of the treatment, refine the MRI assessment of MCs, and further evaluate the impact of the treatment and the pathogenesis of MCs by studying genetic variability and the gene and protein expression of inflammatory biomarkers...
December 15, 2017: Trials
https://www.readbyqxmd.com/read/29214613/antibiotics-in-the-treatment-of-patients-with-lower-back-pain-associated-with-modic-changes-a-case-series
#8
Gaurav Gupta, Peter Jarzem, Sean Meredith, Mohan Radhakrishna, Markus Besemann, Maria Francisca Elgueta, Roshanak Charghi, Jeffrey Chankowsky
PURPOSE: To determine the clinical effect of antibiotic treatment for patients with low back pain and Modic 1 changes. METHODS: This is a retrospective case series of patients treated at the Canadian Forces Health Services Centre in Ottawa and the McGill University Health Centre. Where available, pain, functional, and imaging outcomes in 11 patients treated between 2013 and 2015 were analyzed to determine effect of antibiotic treatment for patients with low back pain and associated Modic 1 changes on magnetic resonance imaging...
October 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/29151051/subclinical-propionibacterium-acnes-infection-estimation-in-the-intervertebral-disc-spine-id-protocol-for-a-prospective-cohort
#9
Nelson Astur, Delio E Martins, Marcelo Wajchenberg, Mario Ferretti, Fernando G Menezes, Andre M Doi, Laercio A Rosemberg, Durval C B Santos, Alexandre S Iutaka, Luciano M R Rodrigues, Marines D V Martino, Jorge R Pagura, Eduardo N Kihara Filho, Mario Lenza
INTRODUCTION: Low back pain and vertebral endplate abnormalities are common conditions within the population. Subclinical infection caused by indolent pathogens can potentially lead to these findings, with differentiation between them notably challenging from a clinical perspective. Progressive infection of the intervertebral disc has been extensively associated with increasing low back pain, with Propionibacterium acnes specifically implicated with in relation to sciatica. The main purpose of this study is to identify if the presence of an infective pathogen within the intervertebral disc is primary or is a result of intraoperative contamination, and whether this correlates to low back pain...
November 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/29141001/the-associations-between-magnetic-resonance-imaging-findings-and-low-back-pain-a-10-year-longitudinal-analysis
#10
Juichi Tonosu, Hiroyuki Oka, Akiro Higashikawa, Hiroshi Okazaki, Sakae Tanaka, Ko Matsudaira
PURPOSE: To conduct a 10-year longitudinal analysis of the relationship between magnetic resonance imaging (MRI) findings and low back pain (LBP). MATERIALS AND METHODS: Ninety-one volunteers with a history of LBP, but without current LBP were recruited between 2005 and 2006. Participants' baseline demographics and MRI findings were recorded. All volunteers were invited for a follow-up MRI in 2016; of these, 49 volunteers (53.8%) participated in the follow-up. We enquired whether they had LBP history during the 10 years between the baseline and follow-up examinations...
2017: PloS One
https://www.readbyqxmd.com/read/29103126/lumbar-total-disc-replacement-predictors-for-long-term-outcome
#11
Håvard Furunes, Christian Hellum, Jens Ivar Brox, Ivar Rossvoll, Ansgar Espeland, Linda Berg, Helga Maria Brøgger, Milada Cvancarova Småstuen, Kjersti Storheim
PURPOSE: We aimed to identify patient characteristics associated with favourable long-term outcomes after lumbar total disc replacement (TDR). METHODS: We analysed a cohort of 82 patients with degenerative disc and chronic low back pain (LBP) who were treated with TDR and originally participated in a randomised trial comparing TDR and multidisciplinary rehabilitation. Potential predictors were measured at baseline, and the outcomes assessed 8 years after they received allocated treatment...
November 4, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29069048/predictive-factors-associated-with-neck-pain-in-patients-with-cervical-disc-degeneration-a-cross-sectional-study-focusing-on-modic-changes
#12
Lingde Kong, Weifeng Tian, Peng Cao, Haonan Wang, Bing Zhang, Yong Shen
The predictive factors associated with neck pain remain unclear. We conducted a cross-sectional study to assess predictive factors, especially Modic changes (MCs), associated with the intensity and duration of neck pain in patients with cervical disc degenerative disease.We retrospectively reviewed patients in our hospital from January 2013 to December 2016. Severe neck pain (SNP) and persistent neck pain (PNP) were the 2 main outcomes, and were assessed based on the numerical rating scale (NRS). Basic data, and also imaging data, were collected and analyzed as potential predictive factors...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29032381/analysis-of-correlation-between-vertebral-endplate-change-and-lumbar-disc-degeneration
#13
Long Xiao, Chunlin Ni, Jiandong Shi, Zhirong Wang, Suchun Wang, Jianwei Zhang, Aiqing Lu
BACKGROUND To evaluate the correlation between vertebral endplate change and the level of lumbar disc degeneration via magnetic resonance imaging (MRI). MATERIAL AND METHODS A total of 345 patients who were recruited from our hospital from May 2012 to May 2016 were evaluated for the presence of intervertebral disc degeneration or herniation. The degree of degeneration was assessed according to Pfirrmann grade. Vertebral endplate change was evaluated based on the endplate concave angle (ECA), and Modic change on sagittal MRI...
October 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29019806/lumbar-vertebral-endplate-defects-on-magnetic-resonance-images-classification-distribution-patterns-and-associations-with-modic-changes-and-disc-degeneration
#14
Zhiyun Feng, Yuanhao Liu, Ge Yang, Michele C Battié, Yue Wang
STUDY DESIGN: A cross-sectional MR imaging study. OBJECTIVE: To classify and characterize endplate defects using routine lumbar MR images, and to determine associations of endplate defects with Modic Changes (MCs) and disc degeneration. SUMMARY OF BACKGROUND DATA: Previously, a cadaveric study revealed that endplate lesions were common and associated with back pain history. New in vivo approaches appropriate for clinical studies are needed to further this potentially important line of research on the clinical significance of endplate lesions, including their relation with MCs, disc degeneration and back pain...
October 10, 2017: Spine
https://www.readbyqxmd.com/read/28985974/what-is-the-role-of-the-bacterium-propionibacterium-acnes-in-type-1-modic-changes-a-review-of-the-literature
#15
REVIEW
Mark Georgy, Mark Stern, Kieran Murphy
This review presents a summary of the pathology and epidemiology of Modic changes and the possible role of Propionibacterium acnes. This information is followed by a synthesis of the most recent clinical research involved in culturing the discs of patients with degenerative disc disease for the presence of bacteria. We also discuss a randomized controlled trial that investigates the effects of antibiotics on patients with chronic low back pain and type 1 Modic changes. We conclude with a brief discussion of the difficulties involved in this research and the significance of the findings...
November 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28947993/the-value-of-radiographic-indexes-in-the-diagnosis-of-discogenic-low-back-pain-a-retrospective-analysis-of-imaging-results
#16
Jian Song, Hong-Li Wang, Xiao-Sheng Ma, Xin-Lei Xia, Fei-Zhou Lu, Chao-Jun Zheng, Jian-Yuan Jiang
To explore value of different radiographic indexes in the diagnosis of discogenic low back pain (LBP). A total number of 120 cases (60 patients diagnosed with discogenic LBP and 60 healthy people) were retrospectively analysed to identify factors in the diagnosis of discogenic LBP by using univariate and multivariate analyses. A receiver operating characteristic (ROC) curve was drew to show the predictive accuracy of the finally enrolled factors. Among all the included patients, 60 were strictly admitted in the discogenic LBP group while the other 60 were enrolled in the control group...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900744/structural-vertebral-endplate-nomenclature-and-etiology-a-study-by-the-issls-spinal-phenotype-focus-group
#17
Uruj Zehra, Cora Bow, Jeffrey C Lotz, Frances M K Williams, S Rajasekaran, Jaro Karppinen, Keith D K Luk, Michele C Battiê, Dino Samartzis
PURPOSE: Vertebral endplate abnormalities may be associated with disc degeneration and, perhaps, pain generation. However, consensus definitions for endplate findings on spine MRI do not exist, posing a challenge to compare findings between studies and ethnic groups. The following survey was created to characterize the variability among the global spine community regarding endplate structural findings with respect to nomenclature and etiology. METHODS: A working group within the International Society for the Study of the Lumbar Spine (ISSLS) Spinal Phenotype Focus Group was established to assess the endplate phenotype...
September 12, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28894387/modic-changes-of-the-cervical-spine-t1-slope-and-its-impact-on-axial-neck-pain
#18
Jia Li, Shuhui Qin, Yongqian Li, Yong Shen
BACKGROUND: The purpose of the research was to evaluate cervical sagittal parameters on magnetic resonance imaging (MRI) in patients with Modic changes and its impact on axial neck pain. METHODS: This study consisted of 266 consecutive asymptomatic or symptomatic patients with Modic changes, whose average age was 50.9±12.6 years from January 2015 to December 2016. Cervical sagittal parameters included sagittal alignment of the cervical spine (SACS), T1 slope, thoracic inlet angle (TIA), and neck tilt (NT)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28890222/identifying-subsets-of-patients-with-single-level-degenerative-disc-disease-for-lumbar-fusion-the-value-of-prognostic-tests-in-surgical-decision-making
#19
Victor E Staartjes, Pieter-Paul A Vergroesen, Dick J Zeilstra, Marc L Schröder
BACKGROUND CONTEXT: Fusion surgery for degenerative disc disease (DDD) has become a standard of care, albeit not without controversy. Outcomes are inconsistent and a superiority over conservative treatment is debatable. Proper patient selection is key to clinical success, and a comprehensive understanding of prognostic tests does not currently exist. PURPOSE: To investigate the value of prognostic tests and sociodemographic factors in predicting outcomes following lumbar fusion surgery for DDD...
September 7, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28884220/inflammatory-response-of-disc-cells-against-propionibacterium-acnes-depends-on-the-presence-of-lumbar-modic-changes
#20
Stefan Dudli, S Miller, S Demir-Deviren, J C Lotz
PURPOSE: Intervertebral disc with Propionibacterium acnes (P. acnes) is suggested to be an etiology of Modic type I changes in the adjacent bone marrow. However it is unknown if disc cells can respond to P. acnes and if bone marrow cells respond to bacterial and disc metabolites draining from infected discs. METHODS: Human disc cells (n = 10) were co-cultured with 10- and 100-fold excess of P. acnes over disc cells for 3 h and 24 h. Lipopolysaccharide was used as positive control...
September 7, 2017: European Spine Journal
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