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https://www.readbyqxmd.com/read/28648909/clinical-efficacy-and-its-prognostic-factor-of-percutaneous-endoscopic-lumbar-annuloplasty-and-nucleoplasty-for-treatment-of-patients-with-discogenic-low-back-pain
#1
Jung Hwan Lee, Sang-Ho Lee
OBJECTIVE: The choice of appropriate treatment of discogenic low back pain (DLBP) was frequently difficult. This study was to identify the clinical efficacy of percutaneous endoscopic lumbar annuloplasty and nucleoplasty (PELAN) to treat the patients with DLBP and to investigate prognostic clinical or radiological variables. METHODS: Eighty-nine patients who underwent PELAN under diagnosis of DLBP were included. Numeric rating scale (NRS) for back pain, Oswestry disability index(%) (ODI%), and modified MacNab criteria were measured at short term(3-4 weeks) and long term follow up period(at least 12 months) to investigate clinical efficacy of PELAN...
June 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28645291/the-effect-of-zoledronic-acid-on-type-and-volume-of-modic-changes-among-patients-with-low-back-pain
#2
Katri Koivisto, Jyri Järvinen, Jaro Karppinen, Marianne Haapea, Markus Paananen, Eero Kyllönen, Osmo Tervonen, Jaakko Niinimäki
BACKGROUND: Modic changes (MC) are associated with low back pain (LBP). In this study, we compared changes in size and type of MC, after a single intravenous infusion of 5 mg zoledronic acid (ZA) or placebo, among chronic LBP patients with MC on magnetic resonance imaging (MRI), and evaluated whether the MRI changes correlate with symptoms. METHODS: All patients (N = 19 in ZA, 20 in placebo) had MRI at baseline (0.23-1.5 T) and at one year (1.5-3 T). We evaluated the level, type and volume of all the MC...
June 23, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28645289/degenerative-changes-of-the-canine-cervical-spine-after-discectomy-procedures-an-in-vivo-study
#3
Peter Grunert, Yu Moriguchi, Brian P Grossbard, Rodolfo J Ricart Arbona, Lawrence J Bonassar, Roger Härtl
BACKGROUND: Discectomies are a common surgical treatment for disc herniations in the canine spine. However, the effect of these procedures on intervertebral disc tissue is not fully understood. The objective of this study was to assess degenerative changes of cervical spinal segments undergoing discectomy procedures, in vivo. RESULTS: Discectomies led to a 60% drop in disc height and 24% drop in foraminal height. Segments did not fuse but showed osteophyte formation as well as endplate sclerosis...
June 23, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28643966/-what-is-the-role-of-surgery-in-low-back-pain-associated-with-modic-changes
#4
Pietro Aniello Laudato, Viktor Bartanusz
Benign low back pain is frequent in the lucratively active population. Degenerative changes are considered the most frequent causes. The identification of pain generators remain challenging. Bone marrow lesions, Modic changes, are frequently associated with benign low back pain, mostly type 1. The etiology of Modic changes is unknown, both infectious and autoimmune mechanisms have been suggested. Despite the strong association of Modic changes with low back pain it is not clear whether lumbar surgery (lumbar fusion, total disc replacement) has any role in the management of these patients...
June 21, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28632548/are-modic-changes-able-to-help-us-in-our-clinical-practice-a-study-of-the-modic-changes-in-young-adults-during-working-age
#5
José V Martínez-Quiñones, José Aso-Escario, Laura González-García, Fabián Consolini, Ricardo Arregui-Calvo
STUDY DESIGN: Modic changes [vertebral endplate spinal changes (VESC)] have been related to degenerative disk disease, and in past decades it was thought that their presence justified the surgical treatment, in particular spinal fusion. OBJECTIVE: The aim of the present study is to investigate its prevalence and features in a population of young workers suffering from low back pain, and explore the eventual relationship with the treatment applied in each case. BACKGROUND DATA: We conducted a retrospectively review of 450 magnetic resonance images from our hospital, in patients with low back pain or sciatica and age below 40...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28552835/effect-of-propionibacterium-acnes-pa-injection-on-intervertebral-disc-degeneration-in-a-rat-model-does-it-mimic-modic-changes
#6
Tomas Zamora, Joaquin Palma, Marcelo Andia, Patricia Garcia, Aniela Wozniak, Antonieta Solar, Mauricio Campos
INTRODUCTION: Multiple reports of bacterial isolates in human disc tissue have suggested a role of low-grade infection on intervertebral disc degeneration (IDD) and Modic Changes (MC) generation. Animal models have been extensively used to study IDD; however, until recently, no consideration had been given to eventual infectious processes. To reproduce the phenomena by inoculating an infecting agent would support the infectious hypothesis. Therefore, we studied the effect of Propionibacterium acnes (PA)inoculation on rat tails and determined whether it would produce MCs on the adjacent endplates...
May 25, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28548999/does-modic-change-progress-with-age
#7
Kiyoshi Tarukado, Teruaki Ono, Osamu Tono, Hiroki Tanaka, Ko Ikuta, Katsumi Harimaya, Toshio Doi
STUDY DESIGN: Cross-sectional imaging study. OBJECTIVE: The aim of this study was to clarify the trend in the generation distinctions about the prevalence of Modic change (MC) including elderly patients. SUMMARY OF BACKGROUND DATA: MC has been discussed regarding its clinical significance, relationship with low back pain, suitable treatments, prevalence, and natural history. However, previous reports have focused on younger subjects, with few studies conducted in elderly patients...
May 25, 2017: Spine
https://www.readbyqxmd.com/read/28496357/incidence-and-risk-factors-of-persistent-low-back-pain-following-posterior-decompression-and-instrumented-fusion-for-lumbar-disk-herniation
#8
Hui Wang, Tao Wang, Qian Wang, Wenyuan Ding
INTRODUCTION: The aim of this study was to explore the incidence and risk factors of persistent low back pain (PLBP) following posterior decompression and instrumented fusion for lumbar disk herniation and to provide references in decision-making and surgical planning for both spinal surgeons and surgically treated patients. PATIENTS AND METHODS: By retrieving the medical records from January 2013 to December 2016, 221 patients were retrospectively reviewed. Patients were classified as having PLBP if numeric rating scale (NRS) scores were >50 at all postoperative follow-up time points (3 months, 6 months, and 12 months)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28431955/the-course-of-modic-vertebral-body-changes-after-posterolateral-lumbar-fusion-on-fused-and-adjacent-levels-a-systematic-review-of-the-literature
#9
REVIEW
Stella Taylor Portella, Marcus André Acioly
According to the original description by Modic et al., the natural course of bone marrow signal abnormalities is an inexorable, progressive one, however recent evidence has demonstrated in healthy individuals and those suffering from lumbar disc herniation that the course of endplate degenerative changes is rather dynamic and sometimes regressive. The evolution of such changes in lumbar fused segments and adjacent levels is largely unknown. The literature relevant to the course of Modic changes on fused and adjacent levels, as well as its clinical correspondence in patients undergoing posterolateral lumbar fusion was collected...
July 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28421295/do-modic-changes-affect-cervical-sagittal-alignment-and-motion-in-symptomatic-patients
#10
Tong Tong, Xian-Da Gao, Jia Li, Jing-Tao Zhang, Rui-Jie Niu, Zhao Liu, Yong Shen
PURPOSE: The cervical segmental instability often occurs simultaneously with Modic changes (MCs). However, it is unknown whether there is a relation between the two diseases. The aim of this study was to evaluate the relationship between MCs and cervical segmental instability, cervical curvature and range of motion (ROM) in the cervical spine. METHODS: A total of 464 patients with neck pain or cervical neurologic symptoms who underwent imaging examination were analyzed retrospectively...
April 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28402320/prevalence-of-modic-changes-in-the-lumbar-vertebrae-and-their-associations-with-workload-smoking-and-weight-in-northern-china
#11
Chao Han, Ming-Jie Kuang, Jian-Xiong Ma, Xin-Long Ma
The distribution of Modic changes (MCs) in the lumbar endplates and the evaluation of the relationships between MCs and risk factors are vital for research into MCs. The T1-weighted and T2-weighted sagittal MRI scans of 210 patients who exhibited lumbar intervertebral disc degeneration were retrospectively reviewed. The patients' weights, genders, smoking statuses, physical activity levels and specific types of MC were recorded. The associations between MCs and risk factors, such as physical work, smoking and body mass index, were also analysed...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28399545/propionibacterium-acnes-incubation-in-the-discs-can-result-in-time-dependent-modic-changes-a-long-term-rabbit-model
#12
Zhi Shan, Xuyang Zhang, Shengyun Li, Tianming Yu, Junhui Liu, Fengdong Zhao
STUDY DESIGN: A case control study of animal model of Modic changes (MCs) on Rabbits. OBJECTIVE: To evaluate the feasibility of inducing of MCs by injection of Propionibacterium acne (P. acnes) into the lumbar intervertebral discs of rabbits. SUMMARY OF BACKGROUND DATA: MCs have been widely observed, and assume to be closely associated with low back pain and P. acnes, but there are few animal models showing the progression of MCs. METHODS: Ten rabbits were used for the study...
April 10, 2017: Spine
https://www.readbyqxmd.com/read/28394776/correlation-analysis-between-modic-change-of-cervical-vertebrae-and-intramedullary-high-signal-intensity
#13
Hao Zhou, Jin Fan, Peng Sun, Wei Zhou, Qingqing Li, Lipeng Yu, Guoyong Yin
PURPOSE: Clinical studies have shown that endplate Modic change in the cervical spine and intramedullary high signal intensity often occurs simultaneously. We aimed to investigate whether there is a correlation between Modic change and intramedullary high signal intensity, and to explore the possible risk factors. MATERIALS AND METHODS: In total, 133 patients with cervical spondylotic myelopathy treated at the First Affiliated Hospital of Nanjing Medical University between May 2009 and March 2013 were enrolled in the study...
April 7, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28377243/hybrid-bone-spect-ct-imaging-in-evaluation-of-chronic-low-back-pain-correlation-with-modic-changes-and-degenerative-disc-disease
#14
Vittorio M Russo, Ranju T Dhawan, Nishanth Dharmarajah, I Baudracco, Antonio I Lazzarino, Adrian T Casey
BACKGROUND CONTEXT: Multiple radiological modalities are used in the evaluation of patients with low back pain (LBP). Only limited evidence currently exists to support the use of Bone HDP (hydroxydiphosphonate) SPECT/CT (Single Photon Emission Computed Tomography) in patients with Modic changes (MC) and degenerative disc disease (DDD). PURPOSE: The aim of this study was to assess the value of the hybrid Bone SPECT/CT imaging in patients with chronic low back pain...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28291179/the-influence-of-direct-inoculation-of-propionibacterium-acnes-on-modic-changes-in-the-spine-evidence-from-a-rabbit-model
#15
Zhi Shan, Xuyang Zhang, Shengyun Li, Tianming Yu, Maiwulanjiang Mamuti, Fengdong Zhao
BACKGROUND: Modic changes (inflammatory-like changes visible on magnetic resonance imaging [MRI] scans of a vertebral end plate) are common and are associated with low back pain, but their origin is unclear. To our knowledge, there have been no previous in vivo animal models of Modic changes. We hypothesized that Modic changes may be related to Propionibacterium acnes. METHODS: Ten New Zealand White rabbits were injected percutaneously with 1 mL of P. acnes (1.6 × 10 colony forming units/mL) into the subchondral bone superior to the L4-L5 and L5-L6 discs; 10 other control rabbits received sham injections at L4-L5 and 1 mL of normal saline solution (vehicle) at L5-L6...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28206726/are-modic-type-2-disc-changes-associated-with-low-grade-infections-a-pilot-study
#16
Lorenzo Drago, Carlo L Romanò, Riccardo Cecchinato, Jorge H Villafañe, Elena De Vecchi, Claudio Lamartina, Pedro Berjano
BACKGROUND: The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs. The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs. METHODS: Sixteen patients with Modic 2 changes were compared with 23 patients without Modic signs...
February 15, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28168339/issls-prize-in-bioengineering-science-2017-automation-of-reading-of-radiological-features-from-magnetic-resonance-images-mris-of-the-lumbar-spine-without-human-intervention-is-comparable-with-an-expert-radiologist
#17
Amir Jamaludin, Meelis Lootus, Timor Kadir, Andrew Zisserman, Jill Urban, Michele C Battié, Jeremy Fairbank, Iain McCall
STUDY DESIGN: Investigation of the automation of radiological features from magnetic resonance images (MRIs) of the lumbar spine. OBJECTIVE: To automate the process of grading lumbar intervertebral discs and vertebral bodies from MRIs. MR imaging is the most common imaging technique used in investigating low back pain (LBP). Various features of degradation, based on MRIs, are commonly recorded and graded, e.g., Modic change and Pfirrmann grading of intervertebral discs...
May 2017: European Spine Journal
https://www.readbyqxmd.com/read/28158154/percutaneous-vertebroplasty-for-symptomatic-schmorl-s-nodes-11-cases-with-long-term-follow-up-and-a-literature-review
#18
Shi-Cheng He, Bin-Yan Zhong, Hai-Dong Zhu, Wen Fang, Li Chen, Jin-He Guo, Gang Deng, Gao-Jun Teng
BACKGROUND: Percutaneous vertebroplasty (PVP) is commonly used to treat symptomatic vertebral compression fractures. However, its long-term effectiveness and safety for use in the treatment of symptomatic Schmorl's nodes (SNs) refractory to conservative treatment is uncertain. OBJECTIVES: To present a case series with PVP for symptomatic SNs not responding to conservative therapy and assess the effectiveness and safety for such treatment with long-term follow-up...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28150049/expert-s-comment-concerning-grand-rounds-case-entitled-rehydration-of-a-degenerated-disc-on-mri-synchronized-with-transition-of-modic-changes-following-stand-alone-xlif-by-k-kita-t-sakai-m-abe-y-takata-and-k-sairyo-eur-spine-j-2017-doi-10-1007-s00586-017-4945
#19
https://www.readbyqxmd.com/read/28144734/rehydration-of-a-degenerated-disc-on-mri-synchronized-with-transition-of-modic-changes-following-stand-alone-xlif
#20
Kenichiro Kita, Toshinori Sakai, Mitsunobu Abe, Yoichiro Takata, Koichi Sairyo
Lumbar intervertebral disc degeneration (LDD) is known to be associated with low back pain (LBP) and leads to degenerative lumbar disease. LDD is considered to be irreversible, and no truly effective treatment that suppresses LDD or regenerates the degenerated disc has been established thus far. Here, we report the case of a 42-year-old woman with a 10-year history of persistent LBP. Magnetic resonance imaging (MRI) demonstrated degenerative changes (Pfirrmann classification: grade IV) in the L4-5 intervertebral disc with type I and III mixed Modic changes adjacent to the disc...
March 2017: European Spine Journal
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