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https://read.qxmd.com/read/34251740/xenon-diffusion-in-ionic-liquids-with-blurred-nanodomain-separation
#1
JOURNAL ARTICLE
Giacomo Saielli, Franca Castiglione, Michele Mauri, Roberto Simonutti, Andrea Mele
The dynamics of xenon gas, loaded in a series of 1-alkyl-3-methylimidazolium based ionic liquids, probes the formation of increasingly blurred polar/apolar nanodomains as a function of the anion type and the cation chain length. Exploiting 129 Xe NMR spectroscopy techniques, like Pulse Gradient Spin Echo (PGSE) and inversion recovery (IR), the diffusion motion and relaxation times are determined for 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [Cn C1 im][TFSI]. A correlation between the ILs nano-structure and both xenon diffusivity and relaxation times, as well as chemical shifts, is outlined...
September 15, 2021: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://read.qxmd.com/read/33730348/trabecular-bone-score-in-women-with-differentiated-thyroid-cancer-on-long-term-tsh-suppressive-therapy
#2
JOURNAL ARTICLE
B É C A Sousa, B C Silva, T de Oliveira Guidotti, M C Pires, M M S Soares, A M Kakehasi
INTRODUCTION: Thyrotropin stimulating hormone (TSH) suppression in patients with differentiated thyroid cancer (DTC) aims to decrease the growth and proliferation of thyroid cancer cells. However, the effect of TSH-suppressive therapy on bone microarchitecture remains undefined. METHODS: Cross-sectional study including 43 women with DTC undergoing TSH-suppressive therapy (sTSH) compared to 20 women also on levothyroxine (LT4) therapy but with TSH in the low-normal range (nTSH) since the thyroid surgery...
October 2021: Journal of Endocrinological Investigation
https://read.qxmd.com/read/33417967/arachidonic-acid-effect-on-the-allosteric-gating-mechanism-of-bk-slo1-channels-associated-with-the-%C3%AE-1-subunit
#3
JOURNAL ARTICLE
Pedro Martín, Melisa Moncada, Karen Castillo, Federico Orsi, Gerónimo Ducca, José Manuel Fernández-Fernández, Carlos Gonzalez, Verónica Milesi
Arachidonic acid (AA) is a fatty acid involved in the modulation of several ion channels. Previously, we reported that AA activates the high conductance Ca2+ - and voltage-dependent K+ channel (BK) in vascular smooth muscle depending on the expression of the auxiliary β1 subunit. Here, using the patch-clamp technique on BK channel co-expressed with β1 subunit in a heterologous cell expression system, we analyzed whether AA modifies the three functional modules involved in the channel gating: the voltage sensor domain (VSD), the pore domain (PD), and the intracellular calcium sensor domain (CSD)...
January 5, 2021: Biochimica et Biophysica Acta. Biomembranes
https://read.qxmd.com/read/27969918/tct-550-influence-of-12-month-late-incomplete-stent-apposition-after-biolimus-eluting-and-sirolimus-eluting-stent-implantation-on-5-year-clinical-outcomes-following-st-segment-elevation-myocardial-infarction-insigths-from-the-sort-out-v-trial-intravascular
#4
JOURNAL ARTICLE
Lisbeth Antonsen, Evald Christiansen, Michael Maeng, Jan Ravkilde, Knud Noerregaard Hansen, Lars Romer Krusell, Leif Thuesen, Mikkel Hougaard, Lisette Okkels Jensen
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://read.qxmd.com/read/25936670/epigenetic-based-therapies-in-the-preclinical-and-clinical-treatment-of-huntington-s-disease
#5
REVIEW
Luis M Valor
The study of epigenetics is providing novel insights about the functional and developmental complexity of the nervous system. In neuropathology, therapies aimed at correcting epigenetic dysregulation have been extensively documented in a large variety of models for neurodegenerative, neurodevelopmental and psychiatric disorders. Taking the treatment of Huntington's disease as a paradigm for the study of these ameliorative strategies, this review updates the main conclusions derived from the use of epigenetic drugs at the preclinical and clinical stages, including actions beyond epigenetics...
October 2015: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/24143051/molecular-docking-study-of-beta-glucosidase-with-cellobiose-cellotetraose-and-cellotetriose
#6
JOURNAL ARTICLE
Nurul Bahiyah Ahmad Khairudin, Nur Shima Fadhilah Mazlan
Beta-glucosidase (3.2.1.21) plays an essential role in the removal of non-reducing terminal glucosyl residues from glycosides. Recently, beta-glucosidase has been of interest for biomass conversion that acts in synergy with two other enzymes, endoglucanase and exo-glucanase. However, there is not much information available on the catalytic interactions of beta-glucosidase with its substrates. Thus, this study reports on the binding modes between beta-glucosidase from glycoside hydrolase family 1 namely BglB with cellobiose, cellotetraose and cellotetriose via molecular docking simulation...
2013: Bioinformation
https://read.qxmd.com/read/22544617/cardiovascular-risk-in-cognitively-preserved-elderlies-is-associated-with-glucose-hypometabolism-in-the-posterior-cingulate-cortex-and-precuneus-regardless-of-brain-atrophy-and-apolipoprotein-gene-variations
#7
COMPARATIVE STUDY
Jaqueline Hatsuko Tamashiro-Duran, Paula Squarzoni, Fábio Luís de Souza Duran, Pedro Kallas Curiati, Homero Pinto Vallada, Carlos Alberto Buchpiguel, Paulo Andrade Lotufo, Mauricio Wajngarten, Paulo Rossi Menezes, Márcia Scazufca, Tânia Corrêa de Toledo Ferraz Alves, Geraldo Filho Busatto
Cardiovascular risk factors (CVRF) possibly contribute to the emergence of Alzheimer's disease (AD). Fluorodeoxyglucose-positron emission tomography (FDG-PET) has been widely used to demonstrate specific patterns of reduced cerebral metabolic rates of glucose (CMRgl) in subjects with AD and in non-demented carriers of the apolipoprotein ε4 (APOE ε4) allele, the major genetic risk factor for AD. However, functional neuroimaging studies investigating the impact of CVRF on cerebral metabolism have been scarce to date...
June 2013: Age (2005-)
https://read.qxmd.com/read/21141677/osmotic-loading-of-in-situ-chondrocytes-in-their-native-environment
#8
JOURNAL ARTICLE
Rami K Korhonen, Sang-Kuy Han, Walter Herzog
Changes in the osmotic environment cause changes in volume of isolated cells and cells in tissue explants, and the osmotic environment becomes hypotonic in cartilage diseases such as osteoarthritis (OA). However, it is not known how cells respond to a hypotonic osmotic challenge when situated in the fully intact articular cartilage. A confocal laser scanning microscope was used to image chondrocytes of intact rabbit patellae in an isotonic (300 mOsm) and hypotonic (172 mOsm) immersion medium. Cell volumes were calculated before and 5, 15, 60, 120 and 240 minutes after the change in saline concentration...
September 2010: Molecular & Cellular Biomechanics: MCB
https://read.qxmd.com/read/19913718/evaluation-of-the-radiopacity-of-some-commercial-and-experimental-root-end-filling-materials
#9
COMPARATIVE STUDY
Rodrigo R Vivan, Ronald Ordinola-Zapata, Clóvis M Bramante, Norberti Bernardineli, Roberto B Garcia, Marco Antonio Hungaro Duarte, Ivaldo Gomes de Moraes
OBJECTIVE: The aim of the present study was to evaluate the radiopacity of 5 root end filling materials (white MTA Angelus, MTA Bio, light-cured MTA, Sealepox RP, and Portland cement clinker with bismuth oxide and calcium sulfate). METHOD: Five specimens, 10 mm in diameter and 1 mm in thickness according to specification ISO 6876:2001 were fabricated from each material and radiographed using Insigth occlusal films close to a graduated aluminum step-wedge (2 to 16 mm in thickness)...
December 2009: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
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