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Luis M Valor
The study of epigenetics is providing novel insights about the functional and developmental complexity of the nervous system. In neuropathology, therapies aimed at correcting epigenetic dysregulation have been extensively documented in a large variety of models for neurodegenerative, neurodevelopmental and psychiatric disorders. Taking the treatment of Huntington's disease as a paradigm for the study of these ameliorative strategies, this review updates the main conclusions derived from the use of epigenetic drugs at the preclinical and clinical stages, including actions beyond epigenetics...
October 2015: International Journal of Biochemistry & Cell Biology
Nurul Bahiyah Ahmad Khairudin, Nur Shima Fadhilah Mazlan
Beta-glucosidase ( plays an essential role in the removal of non-reducing terminal glucosyl residues from glycosides. Recently, beta-glucosidase has been of interest for biomass conversion that acts in synergy with two other enzymes, endoglucanase and exo-glucanase. However, there is not much information available on the catalytic interactions of beta-glucosidase with its substrates. Thus, this study reports on the binding modes between beta-glucosidase from glycoside hydrolase family 1 namely BglB with cellobiose, cellotetraose and cellotetriose via molecular docking simulation...
2013: Bioinformation
Jaqueline Hatsuko Tamashiro-Duran, Paula Squarzoni, Fábio Luís de Souza Duran, Pedro Kallas Curiati, Homero Pinto Vallada, Carlos Alberto Buchpiguel, Paulo Andrade Lotufo, Mauricio Wajngarten, Paulo Rossi Menezes, Márcia Scazufca, Tânia Corrêa de Toledo Ferraz Alves, Geraldo Filho Busatto
Cardiovascular risk factors (CVRF) possibly contribute to the emergence of Alzheimer's disease (AD). Fluorodeoxyglucose-positron emission tomography (FDG-PET) has been widely used to demonstrate specific patterns of reduced cerebral metabolic rates of glucose (CMRgl) in subjects with AD and in non-demented carriers of the apolipoprotein ε4 (APOE ε4) allele, the major genetic risk factor for AD. However, functional neuroimaging studies investigating the impact of CVRF on cerebral metabolism have been scarce to date...
June 2013: Age (2005-)
Rami K Korhonen, Sang-Kuy Han, Walter Herzog
Changes in the osmotic environment cause changes in volume of isolated cells and cells in tissue explants, and the osmotic environment becomes hypotonic in cartilage diseases such as osteoarthritis (OA). However, it is not known how cells respond to a hypotonic osmotic challenge when situated in the fully intact articular cartilage. A confocal laser scanning microscope was used to image chondrocytes of intact rabbit patellae in an isotonic (300 mOsm) and hypotonic (172 mOsm) immersion medium. Cell volumes were calculated before and 5, 15, 60, 120 and 240 minutes after the change in saline concentration...
September 2010: Molecular & Cellular Biomechanics: MCB
Rodrigo R Vivan, Ronald Ordinola-Zapata, Clóvis M Bramante, Norberti Bernardineli, Roberto B Garcia, Marco Antonio Hungaro Duarte, Ivaldo Gomes de Moraes
OBJECTIVE: The aim of the present study was to evaluate the radiopacity of 5 root end filling materials (white MTA Angelus, MTA Bio, light-cured MTA, Sealepox RP, and Portland cement clinker with bismuth oxide and calcium sulfate). METHOD: Five specimens, 10 mm in diameter and 1 mm in thickness according to specification ISO 6876:2001 were fabricated from each material and radiographed using Insigth occlusal films close to a graduated aluminum step-wedge (2 to 16 mm in thickness)...
December 2009: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
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