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Histoplasma cutaneous

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https://www.readbyqxmd.com/read/27707938/development-and-evaluation-of-a-molecular-diagnostic-method-to-rapidly-detect-histoplasma-capsulatum-var-farciminosum-the-causative-agent-of-epizootic-lymphangitis-in-equine-clinical-samples
#1
C E Scantlebury, G L Pinchbeck, P Loughnane, N Aklilu, T Ashine, A P Stringer, L Gordon, M Marshall, R M Christley, A J McCarthy
Histoplasma capsulatum var. farciminosum (HCF), the causative agent of epizootic lymphangitis (EZL), is endemic in parts of Africa. Diagnosis based on clinical signs and microscopy lacks specificity, and is a barrier to further understanding this neglected disease. Here, a nested PCR method targeting the ITS region of the rRNA operon was validated for application to equine clinical samples. Twenty-nine horses with signs of EZL, from different climatic regions of Ethiopia, were clinically examined. Blood samples and aspirates of pus from cutaneous nodules were taken, along with blood from a further 20 horses with no cutaneous EZL lesions...
October 5, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27516534/cutaneous-histoplasmosis-with-prominent-parasitization-of-epidermal-keratinocytes-report-of-a-case
#2
Hedieh H Honarpisheh, Jonathan L Curry, Kristen Richards, Priyadharsini Nagarajan, Phyu P Aung, Carlos A Torres-Cabala, Doina Ivan, Carol R Drucker, Richard Cartun, Victor G Prieto, Michael T Tetzlaff
Disseminated histoplasmosis most commonly occurs in immunosuppressed individuals and involves the skin in approximately 6% of patients. Cutaneous histoplasmosis with an intraepithelial-predominant distribution has not been described. A 47-year-old man was admitted to our institution with fever and vancomycin-resistant enterococcal bacteremia. He had been diagnosed with T-cell prolymphocytic leukemia 4 years earlier and had undergone matched-unrelated-donor stem cell transplant 2 years earlier; on admission, he had relapsed disease...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27227446/histoplasma-capsulatum-sinusitis-possible-way-of-revelation-to-the-disseminated-form-of-histoplasmosis-in-hiv-patients-case-report-and-literature-review
#3
R Elansari, R Abada, S Rouadi, M Roubal, M Mahtar
INTRODUCTION: Histoplasma capsulatum is rarely found in nose and sinuses in immunocompetent and even in immunosupressed patients. A literature review revealed rare cases of H. capsulatum sinusitis and the case we describe in this paper is the first case of H. capsulatum sinusitis in Morocco. The purpose of our work is to present a rare case of H. capsulatum sinusitis and a literature review. CASE REPORT: A male patient, at his 39 presented to the emergency with suffered from nasal congestion and yellow postnasal rhinorrhea, occasional headaches and epistaxis for over than two months...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27166049/primary-cutaneous-histoplasmosis-mimicking-basal-cell-carcinoma-of-the-eyelid-a-case-report-and-review-of-literature
#4
Santhi Radhakrishnan, Namrata G Adulkar, Usha Kim
We present the case of a 46 years old gentleman with longstanding ulcerative lesion of the right upper eyelid. Biopsy of the lesion revealed intracellular periodic acid-Schiff positive round to oval organisms with a surrounding clear halo suggestive of histoplasmosis. Histoplasma capsulatum specific polymerase chain reaction was positive. The patient was treated with oral antifungals and showed a prompt response to treatment. We report this rare case of primary cutaneous histoplasmosis of the eyelid in an otherwise healthy adult patient...
April 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/26976880/disseminated-histoplasmosis-with-skin-lesions-and-osteomyelitis-in-a-patient-from-the-philippines
#5
Marwan M Azar, Maricar F Malinis
Histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, is a disease of protean manifestations and of global distribution. Although increasingly reported in Asia, there are few reports from the Philippines. Here, we describe a case of microbiologically diagnosed histoplasmosis, probably acquired from the Philippines, in a returning traveler who presented with a right foot wound and papular rash. The final diagnosis was disseminated histoplasmosis with cutaneous and bone involvement, both unusual manifestations of the disease...
July 6, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/26597996/diagnosis-of-hiv-infection-on-the-basis-of-histoplasmosis-related-oral-ulceration
#6
Isadora Peres Klein, Marco Antonio Trevizani Martins, Manoela Domingues Martins, Vinicius Coelho Carrard
Histoplasmosis is an endemic systemic mycosis caused by the dimorphic fungus Histoplasma capsulatum. In immunocompromised patients, histoplasmosis generally occurs as an opportunistic disease, with dissemination to various organs. Cutaneous involvement is observed in 38% to 85% of cases, with oral mucosal involvement in 30% to 60% of cases. This article describes the case study of a 32-year-old woman who presented an extensive tongue ulcer due to histoplasmosis and had the HIV infection diagnosis based on laboratory tests requested by the dentist...
March 2016: Special Care in Dentistry
https://www.readbyqxmd.com/read/26449511/burden-of-serious-fungal-infections-in-trinidad-and-tobago
#7
David W Denning, Harish C Gugnani
The information on the prevalence of fungal infections in the Caribbean region including Trinidad and Tobago (population 1,339,000 million) is scanty. Tinea capitis is common in children, being predominant in those of African descent, with no definitive estimate. Asthma is also common affecting 77,000-139,000 adults with an estimated 1927-3491 affected by allergic bronchopulmonary aspergillosis (ABPA) and 2544-4608 with severe asthma and fungal sensitisation (SAFS). An estimated 23,763 women have ≥4 attacks of vaginal candidiasis annually...
October 2015: Mycoses
https://www.readbyqxmd.com/read/26069920/-imported-histoplasmosis
#8
Katarina Stete, Winfried V Kern, Siegbert Rieg, Annerose Serr, Christian Maurer, Kathrin Tintelnot, Dirk Wagner
Infections with Histoplasma capsulatum are rare in Germany, and mostly imported from endemic areas. Infections can present as localized or disseminated diseases in immunocompromised as well as immunocompetent hosts. A travel history may be a major clue for diagnosing histoplasmosis. Diagnostic tools include histology, cultural and molecular detection as well as serology. Here we present four cases of patients diagnosed and treated in Freiburg between 2004 and 2013 that demonstrate the broad range of clinical manifestations of histoplasmosis: an immunocompetent patient with chronic basal meningitis; a patient with HIV infection and fatal disseminated disease; a patient with pulmonary and cutaneous disease and mediastinal and cervical lymphadenopathy; and an immunosuppressed patient with disseminated involvement of lung, bone marrow and adrenal glands...
June 2015: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/25831000/primary-cutaneous-histoplasmosis-developed-in-the-penis-of-an-immunocompetent-patient
#9
Mauricio Paixão, Hélio Amante Miot, João Avancini, Walter Belda Júnior
A 70-year-old male presenting a 3-month history of genital painless erythematous nodules in the balanopreputial sulcus was referred to our service. Histopathological exam presented a chronic dermatitis with epithelioid granulomas and Grocott staining revealed numerous fungal structures with a suggestive morphology of Histoplasma sp. Cultures evidenced Histoplasma capsulatum var. capsulatum. Treatment with oral itraconazole led to complete remission of lesions.
March 2015: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/25550386/molecular-identification-of-fungal-pathogens-in-nodular-skin-lesions-of-cats
#10
Anne Bernhardt, Wolf von Bomhard, Elisabeth Antweiler, Kathrin Tintelnot
In a retrospective study, we investigated 52 formalin-fixed, paraffin-embedded (FFPE) samples from cats with histologically confirmed cutaneous and subcutaneous mycoses to determine if the pathogens could be identified by molecular methods. Aim of the study was to obtain a deep understanding of the spectrum of infectious agents, which, as we hypothesized, was not available by histopathology alone. Detection of feline and fungal DNA was achieved in 92.3% and 94.2% of the samples, respectively. Most of the subcutaneous infections in cats were caused by Alternaria spp...
February 1, 2015: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/25514986/african-histoplasmosis-the-first-report-of-an-indigenous-case-in-india
#11
Sheeba Ravindran, Kunjumani Sobhanakumari, Machiyanickel Celine, Seena Palakkal
OBJECTIVES: African histoplasmosis, caused by Histoplasma capsulatum var. duboisii, is an invasive fungal infection endemic in Central and West Africa. Cases seen outside Africa are generally imported. We report a disseminated purely cutaneous form of this infection in an otherwise healthy person from Kerala, in southern India. METHODS: A 59-year-old farmer presented with asymptomatic, generalized, reddish skin lesions of five months in duration. Dermatologic examination revealed multiple erythematous papules and plaques of varying sizes, predominantly over the trunk and upper limbs...
April 2015: International Journal of Dermatology
https://www.readbyqxmd.com/read/25419751/a-case-report-of-primary-cutaneous-histoplasmosis-requiring-deep-tissue-sampling-for-diagnosis
#12
Ramya Kollipara, Amneet Hans, John Hall, Ken Watson
This is a case of primary cutaneous histoplasmosis, without any systemic involvement, that occurred without a history of trauma. Due to its rarity and varied clinical presentation, there is much difficulty in diagnosis of this disease entitiy, especially in differentiating it from pyoderma gangreosum. This patient required deep tissue sampling and a DNA probe for Histoplasma to establish a time-sensitive diagnosis as multiple superficial biopsies are nondiagnositic.
November 2014: Dermatology Online Journal
https://www.readbyqxmd.com/read/25155354/late-occurrence-of-histoplasma-duboisii-cutaneous-and-pulmonary-infection-18-years-after-exposure
#13
E Régnier-Rosencher, B Dupont, S Jacobelli, A Paugam, A Carlotti, F Boitier, I Gorin, N Dupin, M F Avril
We report an imported case of Histoplasma capsulatum var. duboisii (H. duboisii) infection in a white French woman revealed by cutaneous lesions of the scalp, 18 years after her last stay in West and Central Africa. Asymptomatic bilateral pulmonary infiltrates were discovered on thoracic computed tomography. Skin biopsy allowed the positive diagnosis showing the typical yeasts; culture of biopsy specimens was positive for H. capsulatum. In the absence of criteria of severity, the patient was treated for one year with oral itraconazole 400mg/day...
September 2014: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/25096644/cutaneous-and-bone-marrow-histoplasmosis-after-18-years-of-renal-allograft-transplant
#14
K Y Ibrahim, N B Carvalho, E V Mimicos, H Yeh-Li, M N Sotto, F O S França
The frequency of histoplasmosis among solid organ transplant (SOT) recipients appears to be low where there are only a few case series, mostly among renal and liver transplant recipients. Herein we report a case of a 44-year-old woman who underwent a living-related renal transplant 18 years prior to evaluation, developed a nodule after followed by ulceration upon her posterior right leg and a second one upon her left leg 3 months and 2 months before her hospitalisation, respectively. The biopsy of lesion revealed the presence of Histoplasma spp...
October 2014: Mycopathologia
https://www.readbyqxmd.com/read/24937841/cutaneous-ulcer-in-an-immunosuppressed-patient-with-adult-onset-still-s-disease-primary-cutaneous-histoplasmosis
#15
Michelle Larissa Zini Lise, Ronaldo Nunes Godinho, Flávia Moojen Brollo, Henrique Luiz Staub
Histoplasmosis is caused by the dimorphic fungus Histoplasma capsulatum.Primary infection occurs through inhalation of spores from the air. Immunocompetent individuals are usually asymptomatic, but may develop pulmonary disease. Immunocompromised patients tend to present systemic histoplasmosis with cutaneous lesions occurring by secondary invasion. In this case report, we describe a probable primary cutaneous histoplasmosis (PCH) in a patient with adult onset Still's disease under immunosuppression.
May 2014: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/24772760/primary-cutaneous-histoplasmosis-simulating-molluscum-contagiosum
#16
J Pa, A N Ray, P Sherp, B B Majumdar, D Modak, S Chatterjee, P Sarkar
Primary cutaneous histoplasmosis in a HIV positive patient ie isolated cutaneous involvement without any deeper structures is a very rare entity. Only a handful cases have been reported worldwide. This patient presented with cutaneous lesion simulating Molluscum but histopathology revealed Histoplasma capsulatum. The patient had no deep organ involvement. The patient was put on Itraconazole which caused rapid dissolution of the lesions. He was subsequently put on HAART and discharged.
July 2013: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/24451565/probable-primary-cutaneous-histoplasmosis-in-a-patient-infected-with-hiv
#17
E Gomez-Moyano, V Crespo-Erchiga, A Vera-Casaño
Histoplasmosis is a fungal infection caused by a dimorphic fungus, Histoplasma capsulatum. Most infections occur after inhalation of fungal spores. A wide variety of clinical manifestations can occur depending on the host response and the extent of inoculation. We report a case of probable cutaneous histoplasmosis after trauma in a 26-year-old man from Paraguay who was also infected with the human immunodeficiency virus. Diagnosis was based on histological and mycological examination. No systemic involvement was found...
September 2011: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/24451506/-disseminated-histoplasmosis-due-to-histoplasma-capsulatum-var-duboisii-in-senegal-a-case-in-hiv-infected-patient
#18
D Ndiaye, M Diallo, P D Sene, M Ndiaye, O Ndir
INTRODUCTION: Histoplasmosis, a disease due to Histoplasma capsulatum, is an invasive opportunistic fungal infection, endemic in Africa. So, the occurrence of african histoplasmosis associated with HIV infection has been rarely reported despite the high prevalence of both pathogens in this area. We report the first case of disseminated african histoplasmosis in an HIV-infected Senegalese patient. OBSERVATION: A patient, 50-year-old has been admitted for umbilicate, necrotic and disseminated papulonodular lesions with oral infection, fever and reduction of total body mass...
March 2011: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/23798850/disseminated-histoplasmosis-with-oral-and-cutaneous-manifestations
#19
S Vidyanath, Pm Shameena, S Sudha, Resmi G Nair
Histoplasmosis is a systemic mycotic infection caused by the dimorphic fungus, Histoplasma capsulatum. Systemic histoplasmosis has emerged as an important opportunistic infection in human immunodeficiency virus (HIV) patients and those in endemic areas. Reported cases of histoplasmosis have been low in India with less than 50 cases being reported. We are reporting a case of disseminated histoplasmosis with oral and cutaneous involvement in an HIV seronegative patient.
January 2013: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/23661050/perforation-of-the-nasal-septum-as-the-first-sign-of-histoplasmosis-associated-with-aids-and-review-of-published-literature
#20
REVIEW
Angel Jaimes, Sandra Muvdi, Zulma Alvarado, Gerzaín Rodríguez
Disseminated histoplasmosis in South America is associated with AIDS in 70-90 % of cases. It is visceral and cutaneous, compromising the oral, pharynx, and laryngeal mucous membranes. The involvement of the nasal mucosa is unusual. Two patients with perforation of the nasal septum as the only sign of their disease were clinically and histopathologically diagnosed as leishmaniasis. The revision of the biopsies and the culture of nasal discharge secretions showed that the pathogens seen were not amastigotes but Histoplasma capsulatum...
August 2013: Mycopathologia
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