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Heart failure readmission

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https://www.readbyqxmd.com/read/28634037/clinical-benefit-of-drugs-targeting-mitochondrial-function-as-an-adjunct-to-reperfusion-in-st-segment-elevation-myocardial-infarction-a-meta-analysis-of-randomized-clinical-trials
#1
Gianluca Campo, Rita Pavasini, Giampaolo Morciano, A Michael Lincoff, C Michael Gibson, Masafumi Kitakaze, Jacob Lonborg, Amrita Ahluwalia, Hideki Ishii, Michael Frenneaux, Michel Ovize, Marcello Galvani, Dan Atar, Borja Ibanez, Giampaolo Cerisano, Simone Biscaglia, Brandon J Neil, Masanori Asakura, Thomas Engstrom, Daniel A Jones, Dana Dawson, Roberto Ferrari, Paolo Pinton, Filippo Ottani
AIMS: To perform a systematic review and meta-analysis of randomized clinical trials (RCT) comparing the effectiveness of drugs targeting mitochondrial function vs. placebo in patients with ST-segment elevation myocardial infarction (STEMI) undergoing mechanical coronary reperfusion. METHODS: Inclusion criteria: RCTs enrolling STEMI patients treated with primary percutaneous coronary intervention (PCI) and comparing drugs targeting mitochondrial function vs. placebo...
June 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28630372/multitype-events-and-the-analysis-of-heart-failure-readmissions-illustration-of-a-new-modeling-approach-and-comparison-with-familiar-composite-end-points
#2
Paul M Brown, Justin A Ezekowitz
BACKGROUND: Heart failure-related hospital readmissions and mortality are often outcomes in clinical trials. Patients may experience multiple hospital readmissions over time with mortality acting as a dependent terminal event. Univariate composite end points are used for the analysis of readmissions. We may amend these approaches to include emergency department visits as a further outcome. An alternative multivariate modeling approach that categorizes hospital readmissions and emergency department visits as separate event types is proposed...
June 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28628516/risk-factors-for-readmission-to-hospital-in-adult-patients-with-heart-failure-and-reduced-ejection-fraction-a-systematic-review-protocol
#3
Inge Schjødt, Palle Larsen, Søren Paaske Johnsen, Anna Strömberg, Brian Bridal Løgstrup
The objective of this systematic review is to identify and synthesize the best available evidence on risk factors associated with hospital readmission at different time points within the first year after heart failure (HF) hospitalization in patients suffering from HF with reduced ejection fraction (EF).More specifically, the question is: what are the risk factors for the prediction of hospital readmission within seven, 15, 30, 60, 90, 180 and 365 days of discharge in hospitalized patients with HF with reduced EF aged 18 years or older?...
June 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28627404/pattern-and-outcome-of-heart-failure-related-hospitalization-over-5-years-in-a-remote-australian-population-a-retrospective-administrative-data-cohort-of-617-indigenous-and-non-indigenous-cases
#4
Camilla Tuttle, Matthew Reeves, Ta-Chi Zhong Hu, Ashley K Keates, Stephen Brady, Graeme Maguire, Simon Stewart
AIMS: To understand the pattern and outcomes for heart failure (HF) related hospitalization among Indigenous and non-Indigenous patients living in Central Australia. METHODS AND RESULTS: A retrospective analysis of administrative data for patients presenting with a primary or secondary diagnosis of HF to Central Australia's Alice Springs Hospital during 2008 to 2012 was performed. The population rate of admission and subsequent outcomes (including case-fatality and readmission) during the 5-year study period were examined...
June 13, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28625377/one-year-mortality-outcomes-and-hospital-readmissions-of-patients-admitted-with-acute-heart-failure-data-from-the-trivandrum-heart-failure-registry-in-kerala-india
#5
Sivadasanpillai Harikrishnan, Ganapathi Sanjay, Anubha Agarwal, N Pratap Kumar, K Krishna Kumar, Charantharayil Gopalan Bahuleyan, Govindan Vijayaraghavan, Sunitha Viswanathan, Madhu Sreedharan, R Biju, N Rajalekshmi, Tiny Nair, Krishnan Suresh, Panniyammakal Jeemon
BACKGROUND: There are sparse data on outcomes of patients with heart failure (HF) from India. The objective was to evaluate hospital readmissions and 1-year mortality outcomes of patients with HF in Kerala, India. METHODS: We followed 1,205 patients enrolled in the Trivandrum Heart Failure Registry for 1 year. A trained research nurse contacted each participant every 3 months using a structured questionnaire which included hospital readmission and mortality information...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28625318/prognostic-value-of-different-allelic-polymorphism-of-aldosterone-synthase-receptor-in-a-congestive-heart-failure-european-continental-ancestry-population
#6
Mauro Feola, Martino Monteverde, Daniela Vivenza, Marzia Testa, Laura Leto, Valentina Astesana, Francesco Mussapi, Antonello Vado, Marco Merlano, Cristiana Lo Nigro
Aldosterone synthase (CYP11B2) is as an 9-exon gene on chromosome 8q22 and exists as a common single nucleotide polymorphism C-T transition for position -344. The aim of this study was to assess the -344T/C polymorphism of the aldosterone synthase promoter in a European continental ancestry congestive heart failure (CHF) population. METHODS: Patients discharged after an acute decompensation were enrolled and underwent echocardiography, determination of BNP, evaluation of non-invasive cardiac outputs and determination of -344 T/C SNP in the aldosterone synthase gene...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28623639/anemia-after-continuous-flow-left-ventricular-assist-device-implantation-characteristics-and-implications
#7
Javier Amione-Guerra, Ana S Cruz-Solbes, Arvind Bhimaraj, Barry H Trachtenberg, Sai R Pingali, Jerry D Estep, Myung H Park, Ashrith Guha
BACKGROUND: Anemia is common in patients with heart failure and is associated with adverse outcomes. Management of anemia in CF-LVAD patients is not well studied. Our purpose is to characterize and identify the etiology of anemia in CF-LVAD patients. Secondary objectives are to describe the effect of CF-LVAD on pre-existing anemia and assess its impact after CF-LVAD support. METHODS: Cross-sectional study from January to July 2015 of ambulatory patients supported with a CF-LVAD for at least 6-months that presented with hemoglobin <12 g/dL and no recent gastrointestinal bleeding...
June 14, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28622740/impact-of-a-pharmacist-managed-heart-failure-postdischarge-bridge-clinic-for-veterans
#8
Genevieve M Hale, Sonia L Hassan, Scott L Hummel, Carrie Lewis, David Ratz, Michael Brenner
BACKGROUND: Hospitals that provide early postdischarge follow-up after heart failure (HF) hospitalization tend to have lower rates of readmission. However, HF postdischarge (bridge) clinics have not been extensively evaluated. OBJECTIVE: To assess the impact of a pharmacist-managed HF bridge clinic in a veteran population. METHODS: HF patients hospitalized from November 2010 to August 2013 were identified. Retrospective chart review was conducted of 122 HF patients seen at bridge clinic compared with 122 randomly selected HF patients not seen at this clinic (usual care)...
July 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28620976/oral-nutritional-supplement-use-in-relation-to-length-of-stay-in-heart-failure-patients-at-a-regional-medical-center
#9
Ellen B Babb, James Rohrer
RATIONALE, AIMS, AND OBJECTIVES: Improving the nutritional status of hospitalized patients has been shown to reduce length of stay (LOS), hospital costs, readmission rates, complication rates, and mortality. Provision of nutrient-rich, liquid, oral nutrition supplements (ONS) is one approach to improve nutritional status. Little information is available on ONS use and LOS among heart failure patients. METHODS: This study used a retrospective design to examine whether routine ONS use was associated with hospital LOS among 570 heart failure inpatients (89 ONS = yes; 481 ONS = no) at a regional medical center, adjusting for significant personal, locational, and time variables using multiple logistic regression analysis...
June 16, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28612904/prognostic-value-of-growth-differentiation-factor-15-in-chinese-patients-with-heart-failure-a-prospective-observational-study
#10
Hua Wang, Qingyong Chen, Yingying Li, Xianchao Jing, Jiefu Yang
BACKGROUND: Growth differentiation factor-15 (GDF-15), a biomarker associated with remodeling, oxidative stress and inflammation, has been used to stratify heart failure (HF) patients. However, its prognostic value in Chinese HF patients is still unknown. METHODS: GDF-15 levels were examined on admission in 272 consecutive HF patients in Beijing Hospital (a Chinese tertiary medical center) by a commercial enzyme-linked immunosorbent assay. We recorded the incidence of all-cause mortality and/or readmission for HF during a median follow-up period of 558 days...
June 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28611348/early-detection-of-subclinical-aortic-valve-endocarditis-with-the-cardiomems-heart-failure-system
#11
Sinan Sarsam, Georgy Kaspar, Shukri David, Marcel Zughaib
BACKGROUND The CardioMEMS Heart Failure System is a well validated tool to optimize management of systolic and diastolic heart failure and has been shown to reduce the risk of hospitalization by 37%. We are reporting a unique case of acute aortic valve insufficiency as a first sign of endocarditis, detected early in a patient with the CardioMEMS device. CASE REPORT A 79-year-old man with dual bioprosthetic mitral and aortic valve replacement and non-ischemic cardiomyopathy had a CardioMEMS Heart Failure System implanted 2 months following valve replacement surgery...
June 14, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28606799/patterns-of-readmissions-for-three-common-conditions-among-younger-u-s-adults
#12
Devraj Sukul, Shashank S Sinha, Andrew M Ryan, Michael W Sjoding, Scott L Hummel, Brahmajee K Nallamothu
BACKGROUND: Thirty-day readmissions among elderly Medicare patients are an important hospital quality measure. Although plans for employing 30-day readmission measures are under consideration for younger patients, little is known about readmission in younger patients or the relationship between readmissions in younger and elderly patients at the same hospital. METHODS: Using the 2014 Nationwide Readmissions Database, we examined readmission patterns in younger patients (18- to 64-years-old) using hierarchical models to evaluate associations between hospital 30-day risk-standardized readmission rates (RSRRs) in elderly Medicare patients and readmission risk in younger patients with acute myocardial infarction, heart failure, or pneumonia...
June 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28597803/prognostic-value-of-galectin-3-on-admission-in-chinese-patients-with-heart-failure-a-prospective-observational-study
#13
Hua Wang, Qingyong Chen, Yingying Li, Xianchao Jing, Tianya Liang, Jiefu Yang
Objective We performed a prospective observational study to explore the prognostic value of plasma galectin-3, a biomarker for fibrosis and inflammation, in Chinese patients with heart failure (HF). Methods and results Galectin-3, N-terminal pro B-type natriuretic peptide (NT-proBNP) and other clinically related variables were measured in consecutive HF patients in Beijing Hospital. Specifically, galectin-3 was detected by an enzyme-linked immunosorbent assay. The primary end point was major adverse cardiac events (MACE), including all-cause mortality or readmission at the end of follow-up...
April 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28593038/comprehensive-healthcare-resource-use-among-newly-diagnosed-congestive-heart-failure
#14
Lori D Bash, Dahlia Weitzman, Robert O Blaustein, Ofer Sharon, Varda Shalev, Gabriel Chodick
BACKGROUND: Congestive heart failure (CHF) is among the most common causes of hospital admissions and readmissions in the Western world. However, the burden of ambulatory care has not been as well investigated. The objective of this study was to assess the relative burden and direct medical costs of CHF including inpatient and outpatient care. METHODS: We used longitudinal clinical data from a two-million member health organization in Israel (Maccabi Healthcare Services) to identify adults with newly diagnosed CHF between January 2006 and December 2012, either in the in- or outpatient setting...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28591172/multi-state-modelling-of-heart-failure-care-path-a-population-based-investigation-from-italy
#15
Francesca Gasperoni, Francesca Ieva, Giulia Barbati, Arjuna Scagnetto, Annamaria Iorio, Gianfranco Sinagra, Andrea Di Lenarda
BACKGROUND: How different risk profiles of heart failure (HF) patients can influence multiple readmissions and outpatient management is largely unknown. We propose the application of two multi-state models in real world setting to jointly evaluate the impact of different risk factors on multiple hospital admissions, Integrated Home Care (IHC) activations, Intermediate Care Unit (ICU) admissions and death. METHODS AND FINDINGS: The first model (model 1) concerns only hospitalizations as possible events and aims at detecting the determinants of repeated hospitalizations...
2017: PloS One
https://www.readbyqxmd.com/read/28587613/prognostic-value-of-plasma-dpp4-activity-in-st-elevation-myocardial-infarction
#16
Jing-Wei Li, Yun-Dai Chen, Wei-Ren Chen, Qi You, Bo Li, Hao Zhou, Ying Zhang, Tian-Wen Han
BACKGROUND: Dipeptidyl peptidase-4 (DPP4) regulates blood glucose levels and inflammation, and it is also implicated in the pathophysiological process of myocardial infarction (MI). Plasma DPP4 activity (DPP4a) may provide prognostic information regarding outcomes for ST-segment elevation MI (STEMI) patients. METHODS: Blood samples were obtained from 625 consecutively admitted, percutaneous coronary intervention-treated STEMI patients with a mean age of 57 years old...
June 6, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28586100/obstructive-sleep-apnea-is-associated-with-increased-readmission-in-heart-failure-patients
#17
Alex Sommerfeld, Andrew D Althouse, Jennifer Prince, Charles W Atwood, Suresh R Mulukutla, Gavin W Hickey
BACKGROUND: Heart failure (HF) readmission rates have become an increasingly important quality metric since the advent of the Hospital Readmissions Reduction Program. Despite many well-intentioned efforts to reduce readmissions, clinicians continue to struggle with the problem of high HF readmission rates. HYPOTHESIS: HF patients with obstructive sleep apnea (OSA) will have higher burden of rehospitalization and mortality than HF patients without OSA. METHODS: Our study included 344 patient encounters (among 271 unique patients) with a diagnosis of HF from September 2014 through September 2015...
June 6, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28579167/risk-and-predictors-of-readmission-for-heart-failure-following-a-myocardial-infarction-between-2004-and-2013-a-swedish-nationwide-observational-study
#18
Liyew Desta, Tomas Jernberg, Jonas Spaak, Claes Hofman-Bang, Hans Persson
BACKGROUND: Data are scarce regarding the risk, temporal trends and predictors of late-onset heart failure (LOHF) after acute myocardial infarction (AMI). We aimed at studying the risk and predictors of LOHF and the composite event of LOHF or death after AMI. METHODS: AMI patients first entered in the nationwide SWEDEHEART registry between 2004 and 2013 were included. Patients with a prior history of heart failure (HF) and those who died in-hospital were excluded...
May 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28576264/causes-and-predictors-of-30-day-readmissions-in-atrial-fibrillation-from-the-nationwide-readmissions-database
#19
Muhammad Bilal Munir, Michael S Sharbaugh, Shahzad Ahmad, Shantanu Patil, Kathan Mehta, Andrew D Althouse, Samir Saba
Atrial fibrillation (AF) is the most common cause of arrhythmia-related hospitalizations. We assessed 30-day readmissions in patients admitted with AF in a national sample of US population. Data were extracted from Nationwide Readmissions Database for the calendar year 2013. Patients with primary discharge diagnosis of AF were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification, code 427.31. Patients who died during hospitalization and those <18 years were excluded...
May 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28566364/randomised-trial-of-mitral-valve-repair-with-leaflet-resection-versus-leaflet-preservation-on-functional-mitral-stenosis-the-camra-cardiolink-2-trial
#20
Vincent Chan, Michael W A Chu, Howard Leong-Poi, David A Latter, Judith Hall, Kevin E Thorpe, Benoit E de Varennes, Adrian Quan, Wendy Tsang, Natasha Dhingra, Kibar Yared, Hwee Teoh, F Victor Chu, Kwan-Leung Chan, Thierry G Mesana, Kim A Connelly, Marc Ruel, Peter Jüni, C David Mazer, Subodh Verma
BACKGROUND: The gold-standard treatment of severe mitral regurgitation (MR) due to degenerative disease is valve repair, which is surgically performed with either a leaflet resection or leaflet preservation approach. Recent data suggest that functional mitral stenosis (MS) may occur following valve repair using a leaflet resection strategy, which adversely affects patient prognosis. A randomised comparison of these two approaches to mitral repair on functional MS has not been conducted...
May 30, 2017: BMJ Open
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