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Posterior fossa teratoma

Christopher Daugherty, Thang Ngo, Dennis Drehner, Todd Maugans
Mature teratomas located solely in the posterior fossa are rare. We describe a girl who presented with hydrocephalus caused by a posterior fossa tumor that was ultimately diagnosed as a mature teratoma following complete extirpation. Unusual imaging characteristics which produced confusion preoperatively were, however, very consistent with mature teratomas that are encountered in the gonads. Immature elements were universally absent; therefore, extirpation was curative. Hydrocephalus is unlikely to resolve after tumor removal, and cerebrospinal fluid diversion may be required...
2016: Pediatric Neurosurgery
A Adorno, C Alafaci, F Sanfilippo, D Cafarella, M Scordino, F Granata, G Grasso, F M Salpietro
INTRODUCTION: Klippel-Feil syndrome is characterized by a congenital fusion of cervical vertebrae. Intracranial teratomas are nongerminomatous germ cell tumors and they account for 0.3 to 0.9% of all intracranial tumors. Teratomas with malignant transformation refer to lesions which give rise to malignant cancer of somatic type. The association between tumors of dermoid origin and Klippel-Feil malformation is extremely rare. Only 23 other cases have so far been reported, and only one case of dermoid tumor with areas of dedifferentiation on squamous cell carcinoma has been described...
October 4, 2015: Journal of Medical Case Reports
Tryggve Lundar, Bernt Johan Due-Tønnessen, Arild Egge, Bård Krossnes, Einar Stensvold, Paulina Due-Tønnessen, Petter Brandal
OBJECT: The aim of this study is to delineate the long-term results for patients going through surgery for pediatric brain tumors in the first 6 months of life. METHODS: Thirty consecutive children (1-182 days old) who underwent primary resection for a brain tumor during the years 1973-2012 were included in this retrospective study on surgical morbidity, mortality rate, academic achievement, and/or work participation. Gross motor function and activities of daily life were scored according to the Barthel index...
December 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Hrushikesh U Kharosekar, S Jasmit, V Velho, D A Palande
Congenital orbital teratoma is a rare condition which presents as marked proptosis of eyeball in a newborn. It is rapidly progressive with secondary damage to eyeball due to pressure effect. This case presented by us is of interest due to radiological features and rarity of this tumor extending into posterior fossa.
May 2014: Journal of Pediatric Neurosciences
W Reith, R Mühl-Benninghaus, A Simgen, U Yilmaz
Germ cell tumors, which constitute approximately 3-5% of tumors of the central nervous system (CNS), can be subdivided into germinomas, embryonal carcinomas, yolk sac tumors, choriocarcinomas, teratomas and mixed germ cell tumors. The diagnosis of intracranial germ cell tumor is based on the clinical symptoms, detection of tumor markers, such as alpha fetoprotein (AFP) and the beta subunit of human chorionic gonadotropin (beta-hCG) in blood and cerebrospinal fluid (CSF), magnetic resonance imaging (MRI) of the brain and spinal cord, CSF cytology and histology...
August 2014: Der Radiologe
Sabrine Teixeira Ferraz, Elvis Terci Valera, María Sol Brassesco, Ricardo Santos de Oliveira, Antonio Carlos dos Santos, Fabiano Pinto Saggioro, Luciano Neder, Carlos Alberto Scrideli, Luiz Gonzaga Tone
Teratomas are very rare intracranial tumors and cytogenetic information on this group remains rare. We report a case of a mature teratoma with abnormal +21 trisomy in tumor karyotype ocurring in a non-Down syndrome(DS) infant. Additionally, the evidence for the contribution of chromosome 21 trisomy in this neoplasia are briefly reviewed. The 6-month-old male baby presented with a posterior fossa tumor. Histological evaluation of tumor specimen showed a mature teratoma composed of fully differentiated ectodermal, mesodermal and endodermal components...
April 2014: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Stefanie Catherine Thust, Debjani Nandi, Gayle Hann
An 11-week-old baby was brought to the paediatric emergency department by his mother with a 2-day history of inconsolable crying. On examination, clinical features of macrocephaly, separated sutures and 'sunsetting' of the eyes were noted. Abnormal head circumference measurements had been obtained on several occasions since birth, but were not acted on contrary to local guidance. During the emergency admission, an urgent CT scan revealed a large posterior fossa tumour consistent with a teratoma causing severe obstructive hydrocephalus...
2014: BMJ Case Reports
Kohei Fukuoka, Takaaki Yanagisawa, Tomonari Suzuki, Kenji Wakiya, Masao Matsutani, Atsushi Sasaki, Ryo Nishikawa
Congenital intracranial immature teratomas carry a dismal prognosis, and the usefulness of chemotherapy for these tumors has not been elucidated. The authors report on the successful management of a case of congenital intracranial immature teratoma by using neoadjuvant chemotherapy and surgery after the failure of an initial attempt at resection. The patient was an infant who had begun vomiting frequently at the age of 12 days and had been admitted to a hospital at the age of 18 days with continued vomiting, increased head circumference, and disturbance of consciousness...
January 2014: Journal of Neurosurgery. Pediatrics
Hussein A Algahtani, Mohammed W Al-Rabia, Hatim Q Al-Maghrabi, Husam Y Kutub
Germ cell tumors comprise approximately 2-5% of all childhood brain tumors. They arise predominantly in the pineal and suprasellar region, but may occur throughout the brain. Teratomas are generally divided into gonadal and extragonadal types. A posterior fossa teratoma is a rare occurrence. The focus of this discussion is a 5-year-old boy with posterior fossa teratoma who recovered completely after medical and surgical intervention. We also present his interesting imaging and pathological findings.
October 2013: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Jinxi Gao, Zhaocong Zheng
The present study analyzed a case of immature teratoma in the posterior cranial fossa of an infant and compared the clinical data with the associated literature. Ventricular drainage was initially performed upon the patient's admission to the hospital. Following adequate pre-operative preparations, the tumor in the posterior cranial fossa was resected on the third day. No significant neurological function deficiency was observed following the surgery and no recurrence was noted within an 18-month follow-up period...
July 2013: Oncology Letters
Ashish Aggarwal, Manoj Kumar Tewari, Bishan Radotra, Vivek Gupta
Intrauterine intracranial brain tumor is a rare entity. Traditionally, the outcome of this tumor had been dismal. In a large series of congenital brain tumor, the commonest have been teratoma followed by astrocytoma and craniopharyngioma. We report a case of intracranial dermoid in post-fossa diagnosed at 8 months of intrauterine life during routine prenatal ultrasonography. The child's clinical picture, the surgery performed and the final outcome have been discussed. As far as our knowledge goes, this is perhaps the first reported case of intrauterine-diagnosed intracranial dermoid...
February 2014: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Parikshit Sanyal, Sanghita Barui, Smriti Mathur, Utpal Basak
Intracranial teratomas represent a rare lesion accounting for 0.1%-0.7% of all intracranial tumors. Those in the fourth ventricle have rarely been reported. The present case is that of a 28-year-old man with occipital headache for two months. MRI examination revealed a well-defined extra-axial cystic lesion in posterior fossa in the midline herniating through the foramen magnum. Pre operatively, the mass was seen to be occupying the whole of the posterior fossa and arising from the roof of the fourth ventricle...
2013: Case Reports in Pathology
Mostafa El-Khashab, Taraneh Hashemi Zonouzi, Iman Moeini Naghani, Farideh Nejat
BACKGROUND: Brain abscess in young infants is extremely rare and usually associated with a previous history of bacterial meningitis or septicemia. CASE PRESENTATION: Here we report a cerebellar abscess mimicking brain tumor with atypical clinical and paraclinical presentations. A two-month old previously well-baby boy was referred to us with persistent vomiting, strabismus and developmental regression. The brain imaging showed a right cerebellar mass with multiple small cysts inside the lesion...
December 2012: Iranian Journal of Pediatrics
Manoj Bohara, Hajime Yonezawa, Prasanna Karki, Yuriz Bakhtiar, Hirofumi Hirano, Ikumi Kitazono, Nozomu Matsuyama, Kazunori Arita
We describe a very rare case of mature posterior fossa teratoma in an adult who presented with clinico-radiological findings consistent with a dermoid cyst. A computed tomography scan showed a hypodense mass in the cistern magna with calcification and a sinus tract in the occipital bone. Magnetic resonance imaging revealed a hypo- to hyperintense mass without contrast enhancement. The intraoperative picture showed a dermal sinus and a cyst containing lipid, keratin and hair. Histopathological examination showed a tumor with components of all the three germ layers; thereby, a diagnosis of mature teratoma was made...
October 2013: Brain Tumor Pathology
Yuriz Bakhtiar, Hajime Yonezawa, Manoj Bohara, Ryosuke Hanaya, Yasuhiro Okamoto, Kazuhiko Sugiyama, Takako Yoshioka, Kazunori Arita
BACKGROUND: Intracranial teratoma associated with Down syndrome is rare. With only three previously reported cases, our case is the first one presenting an immature component. CASE DESCRIPTION: A 2-month-old boy with trisomy 21 presented with lethargy and head enlargement. A magnetic resonance imaging (MRI) study showed an obstructive hydrocephalus with 0.5 cm posterior fossa tumor compressing the cerebellum. The tumor revealed a mixed intensity on T1- and T2-weighted MRI images and was surrounded by peritumoral cysts...
2012: Surgical Neurology International
Fang Li, Qiuping Gui, Yueshan Piao
Atypical teratoid/rhabdoid tumor is a highly malignant tumor of the central nervous system, usually occurring in the posterior fossa in infants and young children. Supratentorial example is relatively rare, especially with involvement of the cerebral ventricle system. Herein, we reported 2 cases of atypical teratoid/rhabdoid tumor located in the septum pellucidum within the lateral and third ventricles and right parietooccipital region, respectively. Histopathologically, both of the tumors were composed of rhabdoid tumor cells and mesenchymal components, without primitive neuroectodermal tumor or epithelial differentiation...
March 2013: Journal of Child Neurology
Atsushi Kuge, Shinya Sato, Kaori Sakurada, Sunao Takemura, Takamasa Kayama
Atypical teratoid rhabdoid tumor (AT/RT) is a rare entity. In the central nervous system, AT/RT generally arises from the posterior fossa of infants and behaves aggressively. AT/RT is reported to arise from the infratentorial region (63%) and other sites, such as the suprasellar region, cerebellopontine angle, and spinal cord. The pineal region is rare (6%) as a site of origin. Radiation-induced brain tumors are well known. In this report, we present a case of a pineal region tumor causing acute hydrocephalus that could be pathologically diagnosed as AT/RT following prophylactic cranial irradiation for acute lymphoblastic leukemia...
July 2012: Brain Tumor Pathology
O Coulibaly, I El Kacemi, N Fatemi, R Gana, A Saïdi, R Maaqili, M Jiddane, F Bellakhdar
Intracranial teratomas are congenital neoplasms mostly diagnosed in the pediatric hood and usually involve supratentorial midline structures. These teratomas, especially those involving the posterior fossa are an uncommon and representing less than 0.5% of all intracranial tumors. We report a case of mature posterior fossa teratoma in an adult patient diagnosed in the 4th decade of life. This lesion was taken for a huge infratentorial meningioma.
February 2012: Neuro-Chirurgie
A Hasan, M Palumbo, J Atkinson, A S Carret, J-P Farmer, J Montes, S Albrecht, C Saint-Martin, C R Freeman
BACKGROUND: Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive malignant brain tumor that, since it was first identified, has been treated with aggressive treatment regimens, e.g. high-dose chemotherapy with stem cell rescue and early radiotherapy. We reviewed our experience because of concerns with respect to treatment-related toxicity in our patients. METHODS: Seven patients with a median age at presentation of 18 months were diagnosed with AT/RT between 1996 and 2006...
2011: Pediatric Neurosurgery
Tomotsugu Ichikawa, Shuji Hamazaki, Naoto Sakai, Yoshiro Otsuki, Takafumi Wataya, Hirokazu Kambara, Taro Shuin, Isao Date
We report a case of a cerebellar tumor consisting of a mixed germ cell tumor (GCT) and a hemangioblastoma. A 22-year-old man presented with myoclonus and cerebellar ataxia. Magnetic resonance imaging showed a tumor mass in the left cerebellar hemisphere. The tumor was totally removed, and the histological diagnosis was an undetermined neoplasm. Ten months later, the patient returned with cerebellar hemorrhage at the site of the previous tumor. An emergency craniotomy was performed, and a tumor mass adjacent to the hematoma was resected...
July 2011: Brain Tumor Pathology
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