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https://www.readbyqxmd.com/read/29782566/post-operative-radiation-therapy-in-locally-advanced-non-small-cell-lung-cancer-and-the-impact-of-sequential-versus-concurrent-chemotherapy
#1
EDITORIAL
Mark R Waddle, Stephen Ko, Margaret M Johnson, Yanyan Lou, Robert C Miller, Anna C Harrell, Daniel M Trifiletti
No abstract text is available yet for this article.
April 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29765614/bivalirudin-versus-heparin-in-primary-pci-clinical-outcomes-and-cost-analysis
#2
Pierre Deharo, Thomas W Johnson, Hazim Rahbi, Raveen Kandan, Ruth Bowles, Abdul Mozid, Stephen Dorman, Julian W Strange, Andreas Baumbach
Background: The evidence for benefits of bivalirudin over heparin has recently been challenged. We aimed to analyse the safety and cost-effectiveness following reintroduction of heparin instead of bivalirudin as the standard anticoagulation for primary percutaneous coronary intervention (PPCI) in a high-volume centre. Methods and results: This analysis was an open-label, prospective registry including all patients admitted to our centre for PPCI from April 2014 to April 2016...
2018: Open Heart
https://www.readbyqxmd.com/read/29765610/x-ray-and-cryo-em-structures-of-inhibitor-bound-cytochrome-bc-1-complexes-for-structure-based-drug-discovery
#3
Kangsa Amporndanai, Rachel M Johnson, Paul M O'Neill, Colin W G Fishwick, Alexander H Jamson, Shaun Rawson, Stephen P Muench, S Samar Hasnain, Svetlana V Antonyuk
Cytochrome bc 1 , a dimeric multi-subunit electron-transport protein embedded in the inner mitochondrial membrane, is a major drug target for the treatment and prevention of malaria and toxoplasmosis. Structural studies of cytochrome bc 1 from mammalian homologues co-crystallized with lead compounds have underpinned structure-based drug design to develop compounds with higher potency and selectivity. However, owing to the limited amount of cytochrome bc 1 that may be available from parasites, all efforts have been focused on homologous cytochrome bc 1 complexes from mammalian species, which has resulted in the failure of some drug candidates owing to toxicity in the host...
March 1, 2018: IUCrJ
https://www.readbyqxmd.com/read/29758282/stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-multicenter-retrospective-study-of-377-adult-patients-from-the-united-states
#4
Robert G Micheletti, Zelma Chiesa-Fuxench, Megan H Noe, Sasha Stephen, Maria Aleshin, Ashwin Agarwal, Jennifer Boggs, Adela R Cardones, Jennifer K Chen, Jonathan Cotliar, Mark Dp Davis, Arturo Dominguez, Lindy P Fox, Shayna Gordon, Ronald Hamrick, Baran Ho, Lauren C Hughey, Larry M Jones, Benjamin H Kaffenberger, Kimball Kindley, Daniela Kroshinsky, Bernice Y Kwong, Daniel D Miller, Arash Mostaghimi, Amy Musiek, Alex G Ortega-Loayza, Raj Patel, Alba Posligua, Monica Rani, Sandeep Saluja, Victoria R Sharon, Kanade Shinkai, Jessica St John, Nicole Strickland, Erika M Summers, Natalie Sun, Karolyn A Wanat, David A Wetter, Scott Worswick, Caroline Yang, David J Margolis, Joel M Gelfand, Misha Rosenbach
Stevens-Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) is a rare, severe mucocutaneous reaction with few large cohorts reported. This multicenter retrospective study included patients with SJS/TEN seen by inpatient consultative dermatologists at 18 academic medical centers in the United States. 377 adult patients with SJS/TEN between 1/1/2000 and 6/1/2015 were entered, including 69.0% from 2010 onward. The most frequent cause of SJS/TEN was medication reaction (89.7%), most often trimethoprim / sulfamethoxazole (27...
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29757843/strategies-used-to-facilitate-the-discussion-of-advance-care-planning-with-older-adults-in-primary-care-settings-a-literature-review
#5
Guillermina R Solis, Bibiana M Mancera, Megan Johnson Shen
BACKGROUND AND PURPOSE: The purpose of this literature review was to evaluate strategies used in primary care settings to initiate advance care planning (ACP) conversations leading to the completion of an advance directive (AD). Approximately 50% of older adults have an AD; few talk to their primary care provider (PCP) about end-of-life wishes. The Institute of Medicine report and recent changes in Medicare reimbursement policies create opportunities for PCPs to address ACP in primary care settings...
May 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29753633/does-mesenteric-venous-imaging-assessment-accurately-predict-pathologic-invasion-in-localized-pancreatic-ductal-adenocarcinoma
#6
Jesse Clanton, Stephen Oh, Stephen J Kaplan, Emily Johnson, Andrew Ross, Richard Kozarek, Adnan Alseidi, Thomas Biehl, Vincent J Picozzi, William S Helton, David Coy, Russell Dorer, Flavio G Rocha
BACKGROUND: Accurate prediction of mesenteric venous involvement in pancreatic ductal adenocarcinoma (PDAC) is necessary for adequate staging and treatment. METHODS: A retrospective cohort study was conducted in PDAC patients at a single institution. All patients with resected PDAC and staging CT and EUS between 2003 and 2014 were included and sub-divided into "upfront resected" and "neoadjuvant chemotherapy (NAC)" groups. Independent imaging re-review was correlated to venous resection and venous invasion...
May 9, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29752217/mass-spectrometric-identification-of-urinary-biomarkers-of-pulmonary-tuberculosis
#7
Flonza Isa, Sean Collins, Myung Hee Lee, Diessy Decome, Nancy Dorvil, Patrice Joseph, Lauren Smith, Stephen Salerno, Martin T Wells, Steven Fischer, James M Bean, Jean W Pape, Warren D Johnson, Daniel W Fitzgerald, Kyu Y Rhee
BACKGROUND: Tuberculosis (TB) is the leading infectious cause of death worldwide. A major barrier to control of the pandemic is a lack of clinical biomarkers with the ability to distinguish active TB from healthy and sick controls and potential for development into point-of-care diagnostics. METHODS: We conducted a prospective case control study to identify candidate urine-based diagnostic biomarkers of active pulmonary TB (discovery cohort) and obtained a separate blinded "validation" cohort of confirmed cases of active pulmonary TB and controls with non-tuberculous pulmonary disease for validation...
April 22, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29742105/white-matter-hyperintensities-and-the-mediating-role-of-cerebral-amyloid-angiopathy-in-dominantly-inherited-alzheimer-s-disease
#8
Seonjoo Lee, Molly E Zimmerman, Atul Narkhede, Sara E Nasrabady, Giuseppe Tosto, Irene B Meier, Tammie L S Benzinger, Daniel S Marcus, Anne M Fagan, Nick C Fox, Nigel J Cairns, David M Holtzman, Virginia Buckles, Bernardino Ghetti, Eric McDade, Ralph N Martins, Andrew J Saykin, Colin L Masters, John M Ringman, Stefan Fӧrster, Peter R Schofield, Reisa A Sperling, Keith A Johnson, Jasmeer P Chhatwal, Stephen Salloway, Stephen Correia, Clifford R Jack, Michael Weiner, Randall J Bateman, John C Morris, Richard Mayeux, Adam M Brickman
INTRODUCTION: White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer's disease (AD). One potential explanation is that WMH, conventionally considered a marker of cerebrovascular disease, are a reflection of cerebral amyloid angiopathy (CAA) and that increased WMH in this population is a manifestation of this vascular form of primary AD pathology. We examined whether the presence of cerebral microbleeds, a marker of CAA, mediates the relationship between WMH and estimated symptom onset in individuals with and without autosomal dominant mutations for AD...
2018: PloS One
https://www.readbyqxmd.com/read/29735480/comparative-transcriptomic-response-of-primary-and-immortalized-macrophage-to-murine-norovirus-infection
#9
Eric A Levenson, Craig Martens, Kishore Kanakabandi, Charles V Turner, Kimmo Virtaneva, Monica Paneru, Stacy Ricklefs, Stanislav V Sosnovtsev, Jordan A Johnson, Stephen F Porcella, Kim Y Green
Murine norovirus (NoV) is genetically similar to human NoV and offers both an efficient in vitro cell culture system and an animal model by which to investigate the molecular basis of replication. In this study, we present a detailed global view of host alterations to cellular pathways that occur during the progression of a NoV infection. This was accomplished for both Mus musculus BALB/c-derived RAW264.7 (RAW) cells, an immortalized cell line widely used in in vitro replication studies, and primary bone marrow-derived macrophages (BMDM), representing a permissive in vivo target cell in the host...
May 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29733766/hypermucoviscous-klebsiella-pneumoniae-isolates-from-stranded-and-wild-caught-marine-mammals-of-the-us-pacific-coast-prevalence-phenotype-and-genotype
#10
Dane M Whitaker, Stephen R Reichley, Matt J Griffin, Katherine Prager, Christine A Richey, Kirsten V Kenelty, Brittany N Stevens, James O Lloyd-Smith, Christine K Johnson, Padraig Duignan, Shawn Johnson, Carlos Rios, Robert DeLong, Barbie Halaska, Lauren Rust, Barbara A Byrne, Carsten Struve, Samantha Barnum, Esteban Soto
Emergent hypermucoviscous (HMV) strains of Klebsiella pneumoniae have been reported in multiple marine mammal species; however, there is limited information regarding the epidemiology and pathogenesis of this infection in these species. We determined the prevalence of HMV K. pneumoniae in wild-caught and stranded marine mammal populations on the US Pacific Coast. Samples were collected from 270 free-ranging California sea lions (CSLs, Zalophus californianus) captured at three discrete sampling sites and from 336 stranded marine mammals of various species...
May 7, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29731700/preventing-post-ercp-pancreatitis-the-role-of-prophylactic-pancreatic-duct-stenting-in-the-rectal-nsaid-era
#11
Noor-L-Houda Bekkali, Tom Thomas, Margaret Geraldine Keane, Sam Murray, Deepak Joshi, Ghassan Elsayed, Gavin James Johnson, Michael Huw Chapman, Stephen Paul Pereira, George John Mitchell Webster
Background: Rectal non-steroidal anti-inflammatory drug at endoscopic retrograde cholangiopancreatography is now the standard of care to reduce the risk of post-ERCP pancreatitis. Pancreatic duct stenting also reduces the risk of post- ERCP pancreatitis in high-risk patients, but failed pancreatic duct stenting carries an increased PEP rate (up to 35%). Study Aim: To assess the impact on post-ERCP pancreatitis of successful and unsuccessful pancreatic duct stent placement in the setting of universal rectal non-steroidal anti-inflammatory drug use...
July 2017: JOP: Journal of the Pancreas
https://www.readbyqxmd.com/read/29730243/docosahexaenoic-acid-regulates-the-formation-of-lipid-rafts-a-unified-view-from-experiment-and-simulation
#12
Stephen R Wassall, Xiaoling Leng, Samuel W Canner, Edward Ross Pennington, Jacob J Kinnun, Andres T Cavazos, Sahil Dadoo, Dylan Johnson, Frederick A Heberle, John Katsaras, Saame Raza Shaikh
Docosahexaenoic acid (DHA, 22:6) is an n-3 polyunsaturated fatty acid (n-3 PUFA) that influences immunological, metabolic, and neurological responses through complex mechanisms. One structural mechanism by which DHA exerts its biological effects is through its ability to modify the physical organization of plasma membrane signaling assemblies known as sphingomyelin/cholesterol (SM/chol)-enriched lipid rafts. Here we studied how DHA acyl chains esterified in the sn-2 position of phosphatidylcholine (PC) regulate the formation of raft and non-raft domains in mixtures with SM and chol on differing size scales...
May 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29729138/quantification-of-human-complement-c2-protein-using-an-automated-turbidimetric-immunoassay
#13
Clare Elizabeth Tange, Bridget Johnson-Brett, Alex Cook, Patrick Stordeur, Fabian Brohet, Stephen Jolles, Rachel Steven, Mark Ponsford, Andrew Roberts, Tariq El-Shanawany, Stephen Harding, Gregg Wallis, Antony Richard Parker
BACKGROUND: The measurement of complement components is clinically useful where a deficiency is suspected, or where excessive activation and consumption are present in disease. C2 deficiency carries an increased risk of developing systemic lupus erythematosus, recurrent infections and atherosclerosis. In this study, we have evaluated The Binding Site's Human Complement C2 SPAPLUS® assay. METHODS: Linearity was tested using 13 sample dilutions covering the standard measuring range...
May 5, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29728769/correction-to-patient-adherence-to-dysphagia-recommendations-a-systematic-review
#14
Brittany N Krekeler, Courtney K Broadfoot, Stephen Johnson, Nadine P Connor, Nicole Rogus-Pulia
The original version of this article unfortunately contains mistakes. The second sentence in the section "Results", under the heading "Study Design" was incorrect. It should read as: Two studies [24, 29] used a prospective cohort study design with a JAMA rating of 2. Four studies [17, 25, 27, 34] completed retrospective studies earning a JAMA score of 3. Four studies [26, 28, 30, 33] earned a JAMA quality rating score of 4 and used the following designs: case series [26, 28, 33], and pilot study [30]...
May 4, 2018: Dysphagia
https://www.readbyqxmd.com/read/29726617/copy-number-variant-analysis-using-genome-wide-mate-pair-sequencing
#15
James B Smadbeck, Sarah H Johnson, Stephanie A Smoley, Athanasios Gaitatzes, Travis M Drucker, Roman M Zenka, Farhad Kosari, Stephen J Murphy, Nicole Hoppman, Umut Aypar, William R Sukov, Robert B Jenkins, Hutton M Kearney, Andrew L Feldman, George Vasmatzis
Copy number variation (CNV) is a common form of structural variation detected in human genomes, occurring as both constitutional and somatic events. Cytogenetic techniques like chromosomal microarray (CMA) are widely used in analyzing CNVs. However, CMA techniques cannot resolve the full nature of these structural variations (i.e. the orientation and location of associated breakpoint junctions) and must be combined with other cytogenetic techniques, such as karyotyping or FISH, to do so. This makes the development of a next-generation sequencing (NGS) approach capable of resolving both CNVs and breakpoint junctions desirable...
May 4, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29725242/prospects-for-observing-and-localizing-gravitational-wave-transients-with-advanced-ligo-advanced-virgo-and-kagra
#16
REVIEW
B P Abbott, R Abbott, T D Abbott, M R Abernathy, F Acernese, K Ackley, C Adams, T Adams, P Addesso, R X Adhikari, V B Adya, C Affeldt, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, T Akutsu, B Allen, A Allocca, P A Altin, A Ananyeva, S B Anderson, W G Anderson, M Ando, S Appert, K Arai, A Araya, M C Araya, J S Areeda, N Arnaud, K G Arun, H Asada, S Ascenzi, G Ashton, Y Aso, M Ast, S M Aston, P Astone, S Atsuta, P Aufmuth, C Aulbert, A Avila-Alvarez, K Awai, S Babak, P Bacon, M K M Bader, L Baiotti, P T Baker, F Baldaccini, G Ballardin, S W Ballmer, J C Barayoga, S E Barclay, B C Barish, D Barker, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, M A Barton, I Bartos, R Bassiri, A Basti, J C Batch, C Baune, V Bavigadda, M Bazzan, B Bécsy, C Beer, M Bejger, I Belahcene, M Belgin, A S Bell, B K Berger, G Bergmann, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, S Bhagwat, R Bhandare, I A Bilenko, G Billingsley, C R Billman, J Birch, R Birney, O Birnholtz, S Biscans, A Bisht, M Bitossi, C Biwer, M A Bizouard, J K Blackburn, J Blackman, C D Blair, D G Blair, R M Blair, S Bloemen, O Bock, M Boer, G Bogaert, A Bohe, F Bondu, R Bonnand, B A Boom, R Bork, V Boschi, S Bose, Y Bouffanais, A Bozzi, C Bradaschia, P R Brady, V B Braginsky, M Branchesi, J E Brau, T Briant, A Brillet, M Brinkmann, V Brisson, P Brockill, J E Broida, A F Brooks, D A Brown, D D Brown, N M Brown, S Brunett, C C Buchanan, A Buikema, T Bulik, H J Bulten, A Buonanno, D Buskulic, C Buy, R L Byer, M Cabero, L Cadonati, G Cagnoli, C Cahillane, J Calderón Bustillo, T A Callister, E Calloni, J B Camp, K C Cannon, H Cao, J Cao, C D Capano, E Capocasa, F Carbognani, S Caride, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglià, F Cavalier, R Cavalieri, G Cella, C B Cepeda, L Cerboni Baiardi, G Cerretani, E Cesarini, S J Chamberlin, M Chan, S Chao, P Charlton, E Chassande-Mottin, B D Cheeseboro, H Y Chen, Y Chen, H-P Cheng, A Chincarini, A Chiummo, T Chmiel, H S Cho, M Cho, J H Chow, N Christensen, Q Chu, A J K Chua, S Chua, S Chung, G Ciani, F Clara, J A Clark, F Cleva, C Cocchieri, E Coccia, P-F Cohadon, A Colla, C G Collette, L Cominsky, M Constancio, L Conti, S J Cooper, T R Corbitt, N Cornish, A Corsi, S Cortese, C A Costa, M W Coughlin, S B Coughlin, J-P Coulon, S T Countryman, P Couvares, P B Covas, E E Cowan, D M Coward, M J Cowart, D C Coyne, R Coyne, J D E Creighton, T D Creighton, J Cripe, S G Crowder, T J Cullen, A Cumming, L Cunningham, E Cuoco, T Dal Canton, S L Danilishin, S D'Antonio, K Danzmann, A Dasgupta, C F Da Silva Costa, V Dattilo, I Dave, M Davier, G S Davies, D Davis, E J Daw, B Day, R Day, S De, D DeBra, G Debreczeni, J Degallaix, M De Laurentis, S Deléglise, W Del Pozzo, T Denker, T Dent, V Dergachev, R De Rosa, R T DeRosa, R DeSalvo, R C Devine, S Dhurandhar, M C Díaz, L Di Fiore, M Di Giovanni, T Di Girolamo, A Di Lieto, S Di Pace, I Di Palma, A Di Virgilio, Z Doctor, K Doi, V Dolique, F Donovan, K L Dooley, S Doravari, I Dorrington, R Douglas, M Dovale Álvarez, T P Downes, M Drago, R W P Drever, J C Driggers, Z Du, M Ducrot, S E Dwyer, K Eda, T B Edo, M C Edwards, A Effler, H-B Eggenstein, P Ehrens, J Eichholz, S S Eikenberry, R A Eisenstein, R C Essick, Z Etienne, T Etzel, M Evans, T M Evans, R Everett, M Factourovich, V Fafone, H Fair, S Fairhurst, X Fan, S Farinon, B Farr, W M Farr, E J Fauchon-Jones, M Favata, M Fays, H Fehrmann, M M Fejer, A Fernández Galiana, I Ferrante, E C Ferreira, F Ferrini, F Fidecaro, I Fiori, D Fiorucci, R P Fisher, R Flaminio, M Fletcher, H Fong, S S Forsyth, J-D Fournier, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, E M Fries, P Fritschel, V V Frolov, Y Fujii, M-K Fujimoto, P Fulda, M Fyffe, H Gabbard, B U Gadre, S M Gaebel, J R Gair, L Gammaitoni, S G Gaonkar, F Garufi, G Gaur, V Gayathri, N Gehrels, G Gemme, E Genin, A Gennai, J George, L Gergely, V Germain, S Ghonge, Abhirup Ghosh, Archisman Ghosh, S Ghosh, J A Giaime, K D Giardina, A Giazotto, K Gill, A Glaefke, E Goetz, R Goetz, L Gondan, G González, J M Gonzalez Castro, A Gopakumar, M L Gorodetsky, S E Gossan, M Gosselin, R Gouaty, A Grado, C Graef, M Granata, A Grant, S Gras, C Gray, G Greco, A C Green, P Groot, H Grote, S Grunewald, G M Guidi, X Guo, A Gupta, M K Gupta, K E Gushwa, E K Gustafson, R Gustafson, J J Hacker, A Hagiwara, B R Hall, E D Hall, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, M D Hannam, J Hanson, T Hardwick, J Harms, G M Harry, I W Harry, M J Hart, M T Hartman, C-J Haster, K Haughian, K Hayama, J Healy, A Heidmann, M C Heintze, H Heitmann, P Hello, G Hemming, M Hendry, I S Heng, J Hennig, J Henry, A W Heptonstall, M Heurs, S Hild, E Hirose, D Hoak, D Hofman, K Holt, D E Holz, P Hopkins, J Hough, E A Houston, E J Howell, Y M Hu, E A Huerta, D Huet, B Hughey, S Husa, S H Huttner, T Huynh-Dinh, N Indik, D R Ingram, R Inta, K Ioka, H N Isa, J-M Isac, M Isi, T Isogai, Y Itoh, B R Iyer, K Izumi, T Jacqmin, K Jani, P Jaranowski, S Jawahar, F Jiménez-Forteza, W W Johnson, D I Jones, R Jones, R J G Jonker, L Ju, J Junker, T Kagawa, T Kajita, M Kakizaki, C V Kalaghatgi, V Kalogera, M Kamiizumi, N Kanda, S Kandhasamy, S Kanemura, M Kaneyama, G Kang, J B Kanner, S Karki, K S Karvinen, M Kasprzack, Y Kataoka, E Katsavounidis, W Katzman, S Kaufer, T Kaur, K Kawabe, N Kawai, S Kawamura, F Kéfélian, D Keitel, D B Kelley, R Kennedy, J S Key, F Y Khalili, I Khan, S Khan, Z Khan, E A Khazanov, N Kijbunchoo, C Kim, H Kim, J C Kim, J Kim, W Kim, Y-M Kim, S J Kimbrell, N Kimura, E J King, P J King, R Kirchhoff, J S Kissel, B Klein, L Kleybolte, S Klimenko, P Koch, S M Koehlenbeck, Y Kojima, K Kokeyama, S Koley, K Komori, V Kondrashov, A Kontos, M Korobko, W Z Korth, K Kotake, I Kowalska, D B Kozak, C Krämer, V Kringel, B Krishnan, A Królak, G Kuehn, P Kumar, Rahul Kumar, Rakesh Kumar, L Kuo, K Kuroda, A Kutynia, Y Kuwahara, B D Lackey, M Landry, R N Lang, J Lange, B Lantz, R K Lanza, A Lartaux-Vollard, P D Lasky, M Laxen, A Lazzarini, C Lazzaro, P Leaci, S Leavey, E O Lebigot, C H Lee, H K Lee, H M Lee, H W Lee, K Lee, J Lehmann, A Lenon, M Leonardi, J R Leong, N Leroy, N Letendre, Y Levin, T G F Li, A Libson, T B Littenberg, J Liu, N A Lockerbie, A L Lombardi, L T London, J E Lord, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, C O Lousto, G Lovelace, H Lück, A P Lundgren, R Lynch, Y Ma, S Macfoy, B Machenschalk, M MacInnis, D M Macleod, F Magaña-Sandoval, E Majorana, I Maksimovic, V Malvezzi, N Man, V Mandic, V Mangano, S Mano, G L Mansell, M Manske, M Mantovani, F Marchesoni, M Marchio, F Marion, S Márka, Z Márka, A S Markosyan, E Maros, F Martelli, L Martellini, I W Martin, D V Martynov, K Mason, A Masserot, T J Massinger, M Masso-Reid, S Mastrogiovanni, F Matichard, L Matone, N Matsumoto, F Matsushima, N Mavalvala, N Mazumder, R McCarthy, D E McClelland, S McCormick, C McGrath, S C McGuire, G McIntyre, J McIver, D J McManus, T McRae, S T McWilliams, D Meacher, G D Meadors, J Meidam, A Melatos, G Mendell, D Mendoza-Gandara, R A Mercer, E L Merilh, M Merzougui, S Meshkov, C Messenger, C Messick, R Metzdorff, P M Meyers, F Mezzani, H Miao, C Michel, Y Michimura, H Middleton, E E Mikhailov, L Milano, A L Miller, A Miller, B B Miller, J Miller, M Millhouse, Y Minenkov, J Ming, S Mirshekari, C Mishra, V P Mitrofanov, G Mitselmakher, R Mittleman, O Miyakawa, A Miyamoto, T Miyamoto, S Miyoki, A Moggi, M Mohan, S R P Mohapatra, M Montani, B C Moore, C J Moore, D Moraru, G Moreno, W Morii, S Morisaki, Y Moriwaki, S R Morriss, B Mours, C M Mow-Lowry, G Mueller, A W Muir, Arunava Mukherjee, D Mukherjee, S Mukherjee, N Mukund, A Mullavey, J Munch, E A M Muniz, P G Murray, A Mytidis, S Nagano, K Nakamura, T Nakamura, H Nakano, Masaya Nakano, Masayuki Nakano, K Nakao, K Napier, I Nardecchia, T Narikawa, L Naticchioni, G Nelemans, T J N Nelson, M Neri, M Nery, A Neunzert, J M Newport, G Newton, T T Nguyen, W-T Ni, A B Nielsen, S Nissanke, A Nitz, A Noack, F Nocera, D Nolting, M E N Normandin, L K Nuttall, J Oberling, E Ochsner, E Oelker, G H Ogin, J J Oh, S H Oh, M Ohashi, N Ohishi, M Ohkawa, F Ohme, K Okutomi, M Oliver, K Ono, Y Ono, K Oohara, P Oppermann, Richard J Oram, B O'Reilly, R O'Shaughnessy, D J Ottaway, H Overmier, B J Owen, A E Pace, J Page, A Pai, S A Pai, J R Palamos, O Palashov, C Palomba, A Pal-Singh, H Pan, C Pankow, F Pannarale, B C Pant, F Paoletti, A Paoli, M A Papa, H R Paris, W Parker, D Pascucci, A Pasqualetti, R Passaquieti, D Passuello, B Patricelli, B L Pearlstone, M Pedraza, R Pedurand, L Pekowsky, A Pele, F E Peña Arellano, S Penn, C J Perez, A Perreca, L M Perri, H P Pfeiffer, M Phelps, O J Piccinni, M Pichot, F Piergiovanni, V Pierro, G Pillant, L Pinard, I M Pinto, M Pitkin, M Poe, R Poggiani, P Popolizio, A Post, J Powell, J Prasad, J W W Pratt, V Predoi, T Prestegard, M Prijatelj, M Principe, S Privitera, G A Prodi, L G Prokhorov, O Puncken, M Punturo, P Puppo, M Pürrer, H Qi, J Qin, S Qiu, V Quetschke, E A Quintero, R Quitzow-James, F J Raab, D S Rabeling, H Radkins, P Raffai, S Raja, C Rajan, M Rakhmanov, P Rapagnani, V Raymond, M Razzano, V Re, J Read, T Regimbau, L Rei, S Reid, D H Reitze, H Rew, S D Reyes, E Rhoades, F Ricci, K Riles, M Rizzo, N A Robertson, R Robie, F Robinet, A Rocchi, L Rolland, J G Rollins, V J Roma, R Romano, J H Romie, D Rosińska, S Rowan, A Rüdiger, P Ruggi, K Ryan, S Sachdev, T Sadecki, L Sadeghian, N Sago, M Saijo, Y Saito, K Sakai, M Sakellariadou, L Salconi, M Saleem, F Salemi, A Samajdar, L Sammut, L M Sampson, E J Sanchez, V Sandberg, J R Sanders, Y Sasaki, B Sassolas, B S Sathyaprakash, S Sato, T Sato, P R Saulson, O Sauter, R L Savage, A Sawadsky, P Schale, J Scheuer, E Schmidt, J Schmidt, P Schmidt, R Schnabel, R M S Schofield, A Schönbeck, E Schreiber, D Schuette, B F Schutz, S G Schwalbe, J Scott, S M Scott, T Sekiguchi, Y Sekiguchi, D Sellers, A S Sengupta, D Sentenac, V Sequino, A Sergeev, Y Setyawati, D A Shaddock, T J Shaffer, M S Shahriar, B Shapiro, P Shawhan, A Sheperd, M Shibata, Y Shikano, T Shimoda, A Shoda, D H Shoemaker, D M Shoemaker, K Siellez, X Siemens, M Sieniawska, D Sigg, A D Silva, A Singer, L P Singer, A Singh, R Singh, A Singhal, A M Sintes, B J J Slagmolen, B Smith, J R Smith, R J E Smith, K Somiya, E J Son, B Sorazu, F Sorrentino, T Souradeep, A P Spencer, A K Srivastava, A Staley, M Steinke, J Steinlechner, S Steinlechner, D Steinmeyer, B C Stephens, S P Stevenson, R Stone, K A Strain, N Straniero, G Stratta, S E Strigin, R Sturani, A L Stuver, Y Sugimoto, T Z Summerscales, L Sun, S Sunil, P J Sutton, T Suzuki, B L Swinkels, M J Szczepańczyk, M Tacca, H Tagoshi, S Takada, H Takahashi, R Takahashi, A Takamori, D Talukder, H Tanaka, K Tanaka, T Tanaka, D B Tanner, M Tápai, A Taracchini, D Tatsumi, R Taylor, S Telada, T Theeg, E G Thomas, M Thomas, P Thomas, K A Thorne, E Thrane, T Tippens, S Tiwari, V Tiwari, K V Tokmakov, K Toland, T Tomaru, C Tomlinson, M Tonelli, Z Tornasi, C I Torrie, D Töyrä, F Travasso, G Traylor, D Trifirò, J Trinastic, M C Tringali, L Trozzo, M Tse, R Tso, K Tsubono, T Tsuzuki, M Turconi, D Tuyenbayev, T Uchiyama, T Uehara, S Ueki, K Ueno, D Ugolini, C S Unnikrishnan, A L Urban, T Ushiba, S A Usman, H Vahlbruch, G Vajente, G Valdes, N van Bakel, M van Beuzekom, J F J van den Brand, C Van Den Broeck, D C Vander-Hyde, L van der Schaaf, J V van Heijningen, M H P M van Putten, A A van Veggel, M Vardaro, V Varma, S Vass, M Vasúth, A Vecchio, G Vedovato, J Veitch, P J Veitch, K Venkateswara, G Venugopalan, D Verkindt, F Vetrano, A Viceré, A D Viets, S Vinciguerra, D J Vine, J-Y Vinet, S Vitale, T Vo, H Vocca, C Vorvick, D V Voss, W D Vousden, S P Vyatchanin, A R Wade, L E Wade, M Wade, T Wakamatsu, M Walker, L Wallace, S Walsh, G Wang, H Wang, M Wang, Y Wang, R L Ward, J Warner, M Was, J Watchi, B Weaver, L-W Wei, M Weinert, A J Weinstein, R Weiss, L Wen, P Weßels, T Westphal, K Wette, J T Whelan, B F Whiting, C Whittle, D Williams, R D Williams, A R Williamson, J L Willis, B Willke, M H Wimmer, W Winkler, C C Wipf, H Wittel, G Woan, J Woehler, J Worden, J L Wright, D S Wu, G Wu, W Yam, H Yamamoto, K Yamamoto, T Yamamoto, C C Yancey, K Yano, M J Yap, J Yokoyama, T Yokozawa, T H Yoon, Hang Yu, Haocun Yu, H Yuzurihara, M Yvert, A Zadrożny, L Zangrando, M Zanolin, S Zeidler, J-P Zendri, M Zevin, L Zhang, M Zhang, T Zhang, Y Zhang, C Zhao, M Zhou, Z Zhou, S J Zhu, X J Zhu, M E Zucker, J Zweizig
We present possible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next decade, with the intention of providing information to the astronomy community to facilitate planning for multi-messenger astronomy with gravitational waves. We estimate the sensitivity of the network to transient gravitational-wave signals, and study the capability of the network to determine the sky location of the source. We report our findings for gravitational-wave transients, with particular focus on gravitational-wave signals from the inspiral of binary neutron star systems, which are the most promising targets for multi-messenger astronomy...
2018: Living Reviews in Relativity
https://www.readbyqxmd.com/read/29720402/structural-characterization-of-the-p-1-intermediate-state-of-the-p-cluster-of-nitrogenase
#17
Stephen M Keable, Oleg A Zadvornyy, Lewis E Johnson, Bojana Ginovska, Andrew J Rasmussen, Karamatullah Danyal, Brian J Eilers, Gregory A Prussia, Axl X LeVan, Simone Raugei, Lance C Seefeldt, John W Peters
Nitrogenase is the enzyme that reduces atmospheric dinitrogen (N2 ) to ammonia (NH3 ) in biological systems. It catalyzes a series of single-electron transfers from the donor iron protein (Fe protein) to the molybdenum-iron protein (MoFe protein) that contains the iron-molybdenum cofactor (FeMo-co) sites where N2 is reduced to NH3 The [8Fe-7S] P-cluster in the MoFe protein functions in nitrogenase catalysis as an intermediate electron carrier between the external electron donor, the Fe protein, and the FeMo-co sites of the MoFe protein...
May 2, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29719251/chaperone-mediated-sec61-channel-gating-during-er-import-of-small-precursor-proteins-overcomes-sec61-inhibitor-reinforced-energy-barrier
#18
Sarah Haßdenteufel, Nicholas Johnson, Adrienne W Paton, James C Paton, Stephen High, Richard Zimmermann
Protein transport into the mammalian endoplasmic reticulum (ER) is mediated by the heterotrimeric Sec61 channel. The signal recognition particle (SRP) and TRC systems and Sec62 have all been characterized as membrane-targeting components for small presecretory proteins, whereas Sec63 and the lumenal chaperone BiP act as auxiliary translocation components. Here, we report the transport requirements of two natural, small presecretory proteins and engineered variants using semipermeabilized human cells after the depletion of specific ER components...
May 1, 2018: Cell Reports
https://www.readbyqxmd.com/read/29717954/learning-health-systems-the-research-community-awareness-challenge
#19
Scott McLachlan, Kudakwashe Dube, Derek Buchanan, Stephen Lean, Owen Johnson, Henry Potts, Thomas Gallagher, William Marsh, Norman Fenton
No abstract text is available yet for this article.
March 27, 2018: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29712910/direct-binding-of-cep85-to-stil-ensures-robust-plk4-activation-and-efficient-centriole-assembly
#20
Yi Liu, Gagan D Gupta, Deepak D Barnabas, Fikret G Agircan, Shahid Mehmood, Di Wu, Etienne Coyaud, Christopher M Johnson, Stephen H McLaughlin, Antonina Andreeva, Stefan M V Freund, Carol V Robinson, Sally W T Cheung, Brian Raught, Laurence Pelletier, Mark van Breugel
Centrosomes are required for faithful chromosome segregation during mitosis. They are composed of a centriole pair that recruits and organizes the microtubule-nucleating pericentriolar material. Centriole duplication is tightly controlled in vivo and aberrations in this process are associated with several human diseases, including cancer and microcephaly. Although factors essential for centriole assembly, such as STIL and PLK4, have been identified, the underlying molecular mechanisms that drive this process are incompletely understood...
April 30, 2018: Nature Communications
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