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Early onset psychosis

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https://www.readbyqxmd.com/read/29787962/long-term-outcomes-of-acute-and-transient-psychotic-disorders-the-missed-opportunity-of-preventive-interventions
#1
Grazia Rutigliano, Sergio Merlino, Amedeo Minichino, Rashmi Patel, Cathy Davies, Dominic Oliver, Andrea De Micheli, Philip McGuire, Paolo Fusar-Poli
BACKGROUND: Acute and transient psychotic disorders (ATPD) are characterized by an acute onset and a remitting course, and overlap with subgroups of the clinical high-risk state for psychosis. The long-term course and outcomes of ATPD are not completely clear. METHODS: Electronic health record-based retrospective cohort study, including all patients who received a first index diagnosis of ATPD (F23, ICD-10) within the South London and Maudsley (SLaM) National Health Service Trust, between 1 st April 2006 and 15th June 2017...
May 19, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29781657/longitudinal-stability-of-cognitive-control-in-early-psychosis-nondegenerative-deficits-across-diagnoses
#2
Jason Smucny, Tyler A Lesh, Ana-Maria Iosif, Tara A Niendam, Laura M Tully, Cameron S Carter
Cognitive impairment, particularly in the domain of cognitive control, is characteristic of schizophrenia (SZ) spectrum and bipolar disorders (BDs). The longitudinal trajectory of these impairments, however, remains unclear. Indeed, some studies have observed degeneration and others stability or even improvement over time in these illnesses. Here we examined the longitudinal stability of the AX-Continuous Performance Task (AX-CPT), a cognitive control task, in 52 patients with recent-onset SZ (<2 years from first study measurement), 20 patients with recent-onset BD Type I with psychotic features, and 70 healthy control subjects...
May 21, 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29779964/childhood-trauma-and-clinical-high-risk-for-psychosis
#3
Rachel L Loewy, Sarah Corey, Felix Amirfathi, Sawsan Dabit, Daniel Fulford, Rahel Pearson, Jessica P Y Hua, Danielle Schlosser, Barbara K Stuart, Daniel H Mathalon, Sophia Vinogradov
As a risk factor for psychosis, childhood trauma rates are elevated in the clinical-high-risk (CHR) syndrome compared to the general population. However, it is unknown whether trauma is typically experienced in childhood or adolescence/young adulthood, whether it occurred prior to CHR syndrome onset, and how severe trauma relates to presenting symptoms. In this study, we examined the relationship of trauma history to symptoms and functioning in individuals diagnosed with the CHR syndrome on the Structured Interview for Psychosis-Risk Syndromes (N = 103)...
May 18, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29759055/results-of-a-coordinated-specialty-care-program-for-early-psychosis-and-predictors-of-outcomes
#4
Ilana Nossel, Melanie M Wall, Jennifer Scodes, Leslie A Marino, Sacha Zilkha, Iruma Bello, Igor Malinovsky, Rufina Lee, Marleen Radigan, Thomas E Smith, Lloyd Sederer, Gyojeong Gu, Lisa Dixon
OBJECTIVE: This study prospectively evaluated outcomes of OnTrackNY, a statewide coordinated specialty care (CSC) program for treatment of early psychosis in community settings, as well as predictors of outcomes. METHODS: The sample included 325 individuals ages 16-30 with recent-onset nonaffective psychosis who were enrolled in OnTrackNY and who had at least one three-month follow-up. Clinicians provided data at baseline and quarterly up to one year. Domains assessed included demographic and clinical characteristics, social and occupational functioning, medications, suicidality and violence, hospitalization, and time to intervention...
May 15, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29754121/early-intervention-services-in-greece-time-to-focus-on-people-at-high-risk
#5
S I Bargiota, V P Bozikas, G Garyfallos, P McGuire
Over the last twenty years, a lot of early intervention services operate worldwide with the aim of offering assistance and promoting the early diagnosis and management, not only of people who experience a first episode of psychosis but also of individuals that are at high risk of developing psychosis. The early intervention services that operate in other countries have been reviewed in correlation with the current status of early intervention services for psychosis in Greece. Early intervention services were first established in Australia, and now hundreds of similar programs exist in Europe, North America and Asia...
January 2018: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29740953/recent-violence-and-legal-involvement-among-young-adults-with-early-psychosis-enrolled-in-coordinated-specialty-care
#6
Stephanie A Rolin, Leslie A Marino, Leah G Pope, Michael T Compton, Rufina J Lee, Barry Rosenfeld, Merrill Rotter, Ilana Nossel, Lisa Dixon
AIM: Individuals with serious mental illnesses have a small increased risk of engaging in violence or legal involvement compared to the general population. This seems to be particularly true for young adults experiencing early stages of psychosis. This study analysed the prevalence of and risk factors for reports of violence and legal involvement in a sample of young adults receiving Coordinated Specialty Care for early non-affective psychosis. METHODS: A total of 373 young adults (ages 16-30) within 2 years of the onset of non-affective psychosis were enrolled in 10 Coordinated Specialty Care sites in New York State from October 2013 to August 2016...
May 9, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29730662/anomalous-self-experiences-markers-of-schizophrenia-vulnerability-or-symptoms-of-depersonalization-disorder-a-phenomenological-investigation-of-two-cases
#7
Tor Gunnar Værnes, Jan Ivar Røssberg, Paul Møller
BACKGROUND: Basic self-disturbance (BSD) is proposed to constitute the clinical core of schizophrenia spectrum disorders, including prodromal states and schizotypy. Anomalous self-experiences (ASEs) are suggested as phenotypic variants of BSD, representing markers of schizophrenia vulnerability. However, ASEs are not restricted to the schizophrenia spectrum, but may also occur in non-psychotic states like depersonalization disorder (DPD). It is unclear to what extent the prevalence and nature of ASEs are differing between the two conditions...
May 4, 2018: Psychopathology
https://www.readbyqxmd.com/read/29728871/psychological-interventions-in-psychosis-in-children-and-adolescents-a-systematic-review
#8
REVIEW
Nefeli Anagnostopoulou, Marinos Kyriakopoulos, Anca Alba
BACKGROUND: Early onset psychosis (EOP), referring to psychosis with onset before the age of 18 years, is a more severe form of psychosis associated with worse prognosis. While medication is the treatment of choice, psychological interventions are also considered to have an important role in the management of symptoms and disability associated with this condition. The present review aimed to explore the effectiveness of such interventions. METHOD: An electronic search was conducted on the Embase, Medline, and PsychInfo databases for papers of randomized controlled trials (RCTs) referring to psychological interventions in EOP...
May 4, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29717522/brain-morphologic-changes-in-early-stages-of-psychosis-implications-for-clinical-application-and-early-intervention
#9
Tsutomu Takahashi, Michio Suzuki
To date, a large number of magnetic resonance imaging (MRI) studies have been conducted in schizophrenia, which generally demonstrate gray matter reduction predominantly in the frontal and temporo-limbic regions, as well as gross brain abnormalities (e.g., a deviated sulcogyral pattern). Although the causes as well as timing and course of these findings remain elusive, these morphologic changes (especially gross brain abnormalities and medial temporal lobe atrophy) are likely present at illness onset, possibly reflecting early neurodevelopmental abnormalities...
May 1, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29712475/developmental-delay-treatment-resistant-psychosis-and-early-onset-dementia-in-a-man-with-22q11-deletion-syndrome-and-huntington-s-disease
#10
Martilias Farrell, Maya Lichtenstein, James J Crowley, Dawn M Filmyer, Gabriel Lázaro-Muñoz, Rita A Shaughnessy, Ian R Mackenzie, Veronica Hirsch-Reinshagen, Robert Stowe, James P Evans, Jonathan S Berg, Jin Szatkiewicz, Richard C Josiassen, Patrick F Sullivan
No abstract text is available yet for this article.
May 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29710118/disorganized-gyrification-network-properties-during-the-transition-to-psychosis
#11
Tushar Das, Stefan Borgwardt, Daniel J Hauke, Fabienne Harrisberger, Undine E Lang, Anita Riecher-Rössler, Lena Palaniyappan, André Schmidt
Importance: There is urgent need to improve the limited prognostic accuracy of clinical instruments to predict psychosis onset in individuals at clinical high risk (CHR) for psychosis. As yet, no reliable biological marker has been established to delineate CHR individuals who will develop psychosis from those who will not. Objectives: To investigate abnormalities in a graph-based gyrification connectome in the early stages of psychosis and to test the accuracy of this systems-based approach to predict a transition to psychosis among CHR individuals...
April 25, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29698400/the-complex-association-between-the-antioxidant-defense-system-and-clinical-status-in-early-psychosis
#12
Saínza García, Susana Alberich, Mónica Martínez-Cengotitabengoa, Celso Arango, Josefina Castro-Fornieles, Mara Parellada, Inmaculada Baeza, Carmen Moreno, Juan Antonio Micó, Esther Berrocoso, Montserrat Graell, Soraya Otero, Tatiana Simal, Ana González-Pinto
Oxidative stress is a pathophysiological mechanism potentially involved in psychiatric disorders. The objective of this study was to assess the relationship between total antioxidant status (TAS) and the functional status of patients with a first episode of psychosis at the onset of the disease. For this purpose, a sample of 70 patients aged between 9 and 17 years with a first episode of psychosis were followed up for a period of two years. Blood samples were drawn to measure TAS levels at three time points: at baseline, at one year, and at two years...
2018: PloS One
https://www.readbyqxmd.com/read/29675994/psychotic-like-experiences-in-pre-adolescence-what-precedes-the-antecedent-symptoms-of-severe-mental-illness
#13
K Bolhuis, M E Koopman-Verhoeff, L M E Blanken, D Cibrev, V W V Jaddoe, F C Verhulst, M H J Hillegers, S A Kushner, H Tiemeier
OBJECTIVE: Adolescent psychotic-like experiences predict the onset of psychosis, but also predict subsequent non-psychotic disorders. Therefore, it is crucial to better understand the aetiology of psychotic-like experiences. This study examined whether (a) child emotional and behavioural problems at 3 and 6 years, or (b) childhood adversities were associated with psychotic-like experiences at age 10 years. METHOD: This prospective study was embedded in the Generation R Study; 3984 children (mean age 10 years) completed a psychotic-like experiences questionnaire...
April 19, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29659460/clozapine-titration-for-people-in-early-psychosis-a-chart-review-and-treatment-guideline
#14
Jacob S Ballon, Hera Ashfaq, Douglas L Noordsy
PURPOSE/BACKGROUND: The use of clozapine, particularly in young people, is often limited by early treatment-emergent adverse effects including drowsiness and lethargy. Concerns about adverse effects, medication adherence, and the need for blood monitoring often impede the use of clozapine in this population, leading to repeated trials of less effective medications. Current clozapine dosing recommendations are based on people further in the course of their illness and thus reflect different responsiveness and sensitivities to antipsychotic medication...
June 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29656909/corpus-callosum-shape-and-morphology-in-youth-across-the-psychosis-spectrum
#15
D M Prendergast, K H Karlsgodt, C L Fales, B A Ardekani, P R Szeszko
The corpus callosum is the largest white matter tract in the human brain connecting and coordinating homologous regions of the right and left hemispheres and has been strongly implicated in the pathogenesis of psychosis. We investigated corpus callosum morphology in a large community cohort of 917 individuals (aged 8-21), including 267 endorsing subsyndromal or threshold psychotic symptoms (207 on the psychosis spectrum and 60 with limited psychosis based on previously published criteria) and 650 non-psychotic volunteers...
April 12, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29614389/duration-of-active-psychosis-and-functional-outcomes-in-first-episode-non-affective-psychosis
#16
José María Pelayo-Terán, Virginia Gajardo-Galán, Marcos Gómez-Revuelta, Victor Ortiz-García de la Foz, Rosa Ayesa-Arriola, Rafael Tabarés-Seisdedos, Benedicto Crespo-Facorro
BACKGROUND: The duration of untreated psychosis (DUP) has been associated with negative outcomes in psychosis; however, few studies have focused on the duration of active psychotic symptoms after commencing treatment (DAT). In this study, we aimed to evaluate the effect of DUP and DAT on functional long-term outcomes (3 years) in patients with early psychosis. METHODS: We evaluated the Scale for the Assessment of Positive Symptoms (SAPS) at frequent intervals for 3 years after presentation to determine the DAT for 307 individuals with first-episode psychosis together with DUP and clinical variables...
March 31, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29593580/self-reported-visual-perceptual-abnormalities-are-strongly-associated-with-core-clinical-features-in-psychotic-disorders
#17
Brian P Keane, Lisa N Cruz, Danielle Paterno, Steven M Silverstein
Background: Past studies using the Bonn Scale for the Assessment of Basic Symptoms (hereafter, Bonn Scale) have shown that self-reported perceptual/cognitive disturbances reveal which persons have or will soon develop schizophrenia. Here, we focused specifically on the clinical value of self-reported visual perceptual abnormalities (VPAs) since they are underexplored and have been associated with suicidal ideation, negative symptoms, and objective visual dysfunction. Method: Using the 17 Bonn Scale vision items, we cross-sectionally investigated lifetime occurrence of VPAs in 21 first-episode psychosis and 22 chronic schizophrenia/schizoaffective disorder (SZ/SA) patients...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29575691/individual-factors-influencing-the-duration-of-untreated-psychosis
#18
Lama Souaiby, Claire Gauthier, Mathilde Kazes, Célia Mam-Lam-Fook, Claire Daban, Marion Plaze, Raphaël Gaillard, Marie-Odile Krebs
AIM: Duration of untreated psychosis (DUP), or the time between onset of psychosis and treatment initiation, is a prognostic factor of schizophrenia. However, few studies evaluated the relative influence of individual-related factors on this duration. The objective of this study was to evaluate the influence of socio-demographic, clinical and cannabis use on DUP. METHODS: This study was part of a large prospective study in help-seeking individuals referred to our specialized early detection / intervention clinic in the Service Hospitalo-Universitaire of Sainte-Anne Hospital in Paris (ICAAR study)...
March 25, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29573345/do-clinical-characteristics-predict-the-cognitive-course-in-early-onset-schizophrenia-spectrum-disorders
#19
Charlotte M Teigset, Christine Mohn, Cathrine Brunborg, Monica Juuhl-Langseth, Aina Holmén, Bjørn Rishovd Rund
BACKGROUND: Being in a period with extensive brain maturation, adolescents with early-onset schizophrenia-spectrum disorders (EOS) provide unique neurodevelopmental data that may contribute to a better understanding of schizophrenia at all ages. Cognitive dysfunction is a central feature of schizophrenia and is more pronounced in EOS than in later onset illness. However, there is limited research on both the long-term course of global cognition in EOS, and how cognition over time is influenced by clinical characteristics during the early illness period...
March 24, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29546860/neurophysiological-correlates-of-excitement-in-men-with-recent-onset-psychosis
#20
Alexander Sumich, Anthony Harris, Thomas Whitford, Daniel Hermens, Nadja Heym, John Anderson, Claire Bloxsom, Fraenze Kibowski, Veena Kumari
OBJECTIVE: Right frontal function, as indicated by the N200 component of the event-related potential during target detection, has previously been associated with excitement (excitement, impulsivity, hostility, uncooperativeness) in men with a long-term diagnosis of schizophrenia. The current study investigated excitement in relation to N200 in men who had recently experienced their first episode of psychosis. SUBJECTS AND METHODS: Twenty men who had recently suffered their first psychotic episode underwent a clinical interview and auditory oddball task...
March 2018: Psychiatria Danubina
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