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Early onset psychosis

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https://www.readbyqxmd.com/read/28928050/predictors-of-onset-of-psychosis-in-patients-with-parkinson-s-disease-who-gets-it-early
#1
Abhishek Lenka, Lija George, Shyam Sundar Arumugham, Shantala Hegde, Venkateswara Reddy, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal
INTRODUCTION: Psychosis is one of the common non-motor symptoms of PD, which substantially worsens the quality of life. Hence, it is important to identify factors that are associated with early onset of psychosis in PD. In order to identify those factors, the current study aims to compare various demographic and clinical features of PD patients with early and late onset psychosis. METHODOLOGY: In this prospective case-control study, 51 consecutive patients with PD having psychosis (PDP) were recruited...
September 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28922588/persistent-negative-symptoms-in-first-episode-psychosis-early-cognitive-and-social-functioning-correlates-and-differences-between-early-and-adult-onset
#2
Olga Puig, Immaculada Baeza, Elena de la Serna, Bibiana Cabrera, Gisela Mezquida, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Mara Parellada, Iluminada Corripio, Eduard Vieta, Julio Bobes, Judith Usall, Fernando Contreras, Manuel J Cuesta, Miquel Bernardo, Josefina Castro-Fornieles, The PEPs Group
OBJECTIVE: To characterize the early cognitive and social functioning characteristics of a sample of first-episode psychosis patients with and without persistent negative symptoms (PNS) and to examine the prevalence and cognitive and functional correlates of PNS in patients with early-onset versus adult-onset first-episode psychosis. METHODS: Participants were 235 patients with first-episode psychosis (51 early-onset, 184 adult-onset) and 240 healthy controls from a multicenter longitudinal study (recruited between 2009 and 2011)...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28901206/rural-urban-differences-in-accessing-mental-health-treatment-in-patients-with-psychosis
#3
Jagadisha Thirthalli, K Shanivaram Reddy, Manoranjitha Kare, Soumitra Das, B N Gangadhar
BACKGROUND: Delay in accessing psychiatric treatment has considerable influence on the outcome of psychoses. Systematic studies examining the source of the delay are lacking in India. In this article, we examine rural-urban differences regarding delay in accessing psychiatric care in patients with psychosis, an issue which was hitherto not studied. AIMS: To evaluate the rural-urban differences in treatment seeking among patients with psychosis. METHODS: Patients with psychotic disorders who presented to the outpatient department of an academic psychiatric institute for the first time ( n = 551) were interviewed using a semi-structured interview tool to assess the date of onset of illness...
September 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28888362/risk-factors-for-increased-duration-of-untreated-psychosis-results-from-the-face-sz-dataset
#4
G Fond, L Boyer, M Andrianarisoa, O Godin, L Brunel, E Bulzacka, N Coulon, P M Llorca, F Berna, B Aouizerate, D Capdevielle, T D'Amato, C Dubertret, J Dubreucq, C Faget, F Gabayet, J Mallet, D Misdrahi, R Rey, R Richieri, P Roux, C Passerieux, A Schandrin, A M Tronche, P Vidailhet, M Leboyer, F Schürhoff
OBJECTIVES: Reducing the duration of untreated psychosis (DUP) may improve the prognosis of schizophrenia. This study investigated the prevalence, and associated risk factors, of long DUP in a large, non-selected sample of community-dwelling schizophrenia patients (SZ). METHOD: 478 community-dwelling stable SZ participants (122 women and 356 men; mean age 32.37±9.86years) were recruited between 2010 and 2016. The mean retrospective DUP was evaluated from both patient and family reports, as well as hospital/psychiatrists records...
September 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28888360/an-examination-of-components-of-recovery-after-five-years-of-treatment-in-an-early-intervention-program-for-psychosis
#5
Ross M G Norman, Arlene MacDougall, Rahul Manchanda, Raj Harricharan
Recovery from psychotic disorders includes both symptomatic and functional components. Progress in understanding recovery requires careful replication and extension of findings using comparable measures. In the current paper, we present a study of five year recovery rates in an early intervention program in London, Canada with the same operational criteria as those used in a previous report from the OPUS cohort in Denmark. Our analysis extends the OPUS reports by including additional potential predictors of overall recovery, such as cognitive functioning, adherence to medication and early social support, and examining rates and predictors of individual components of recovery at five year follow-up...
September 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28870686/-risk-factors-related-to-homicide-in-moroccan-patients-with-schizophrenia
#6
A Kachouchi, M Sebbani, S Salim, I Adali, F Manoudi, M Amine, F Asri
BACKGROUND: Persons with schizophrenia are thought to be at increased risk of committing violent crime - 4 to 6 times the level of general population individuals without this disorder. The relationship between schizophrenia and homicide is complex and cannot be reduced to a simple causal link. OBJECTIVES: The objectives of this study were to describe the characteristics of homicide in Moroccan patients suffering from schizophrenia and to determine the correlated sociodemographic, clinical and toxic variables...
September 1, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28852253/very-early-onset-schizophrenia-with-secondary-onset-tic-disorder
#7
Shilpa A Telgote, Shreyas Shrikant Pendharkar, Amol D Kelkar, Sachin Bhojane
Very early-onset schizophrenia (defined as an onset of psychosis before 13 years of age) is a rare and severe form of the disorder which is clinically and neurobiologically continuous with the adult-onset disorder. It is rarely reported <12 years of age in Indian literature. Here, we present a 15-year-old boy who developed psychosis at 9 years of age and during illness developed tic disorder.
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28830453/experiences-of-antipsychotic-use-in-patients-with-early-psychosis-a-two-year-follow-up-study
#8
Rafal A H Yeisen, Jone Bjornestad, Inge Joa, Jan Olav Johannessen, Stein Opjordsmoen
BACKGROUND: Non-adherence is a major public health problem despite treatment advances. Poor drug adherence in patients with psychosis is associated with more frequent relapse, re-hospitalization, increased consumption of health services and poor outcomes on a variety of measures. Adherence rate in patients with first episode psychosis have been found to vary from 40 to 60%. However, most previous studies have addressed the consequences of non-adherence rather than its potential causes...
August 22, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28828697/metacognitive-training-in-patients-recovering-from-a-first-psychosis-an-experience-sampling-study-testing-treatment-effects
#9
Karin Pos, Carin J Meijer, Oukje Verkerk, Onno Ackema, Lydia Krabbendam, Lieuwe de Haan
Cognitive biases, negative affect and negative self-esteem are associated with paranoia in people with psychotic disorders. Metacognitive group training (MCT) aims to target these biases although research has shown mixed results. Our objective was to establish the effect of MCT on paranoid ideation in patients with recent onset psychosis in a powerful experience sampling design. 50 patients between the age of 18 and 35 were included in a single-blind, parallel group RCT comparing MCT with occupational therapy (OT) as an active control condition...
August 21, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28817993/early-psychosis-in-central-vietnam-a-longitudinal-study-of-short-term-functional-outcomes-and-their-predictors
#10
Seiji Humphries, Robert King, Michael P Dunne, Cat Huu Nguyen
BACKGROUND: Few longitudinal studies have investigated the functional outcomes of individuals with recent-onset psychotic illness in low- and middle-income countries. AIMS: To investigate short-term functional remission and its predictors in a central Vietnamese sample. METHODS: A naturalistic 6-month prospective cohort study recruited 79 patients of public health facilities who had experienced a first episode of schizophrenia or related illness in the past 18 months...
August 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28768599/pre-onset-risk-characteristics-for-mania-among-young-people-at-clinical-high-risk-for-psychosis
#11
Aswin Ratheesh, Susan M Cotton, Christopher G Davey, Ashleigh Lin, Stephen Wood, Hok Pan Yuen, Andreas Bechdolf, Patrick D McGorry, Alison Yung, Michael Berk, Barnaby Nelson
INTRODUCTION: Psychosis and mania share conceptual, genetic and clinical features, which suggest the possibility that they have common antecedents. Participants identified to be at-risk for psychosis might also be at-risk for mania. We aimed to identify the rate and predictors of transition to mania in a cohort of youth with clinical or familial risk for psychosis. METHODS: Among a cohort of 416 young people with an at-risk mental state for psychosis defined using the Ultra-High-Risk (UHR) criteria, 74...
May 4, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28764561/cpa-guidelines-for-the-pharmacological-treatment-of-schizophrenia-spectrum-and-other-psychotic-disorders-in-children-and-youth
#12
Sabina Abidi, Irfan Mian, Iliana Garcia-Ortega, Tania Lecomte, Thomas Raedler, Kevin Jackson, Kim Jackson, Tamara Pringsheim, Donald Addington
OBJECTIVE: Schizophrenia spectrum and other psychotic disorders often have their onset in adolescence. The sequelae of these illnesses can negatively alter the trajectory of emotional, cognitive, and social development in children and youth if left untreated. Early and appropriate interventions can improve outcomes. This article aims to identify best practices in the pharmacotherapy management of children and youth with schizophrenia spectrum disorders. METHODS: A systematic search was conducted for published guidelines for schizophrenia and schizophrenia spectrum disorders in children and youth (under age 18 years)...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28748485/early-onset-first-episode-psychosis-dimensional-structure-of-symptoms-clinical-subtypes-and-related-neurodevelopmental-markers
#13
Maria Giuseppina Petruzzelli, Lucia Margari, Andrea Bosco, Francesco Craig, Roberto Palumbi, Francesco Margari
Despite the growing interest in a dimensional approach to the assessment of symptoms and clinically relevant phenomena in schizophrenia spectrum disorders, very few studies, to date, have examined the dimensional structure of symptoms in early onset first episode psychosis. In the present study, we assessed a sample of 60 children and adolescents of both sexes with first episode schizophrenia spectrum psychosis. A principal component analysis (PCA) of the Positive and Negative Syndrome Scale (PANSS) was performed and the factors obtained were used to carry out a cluster analysis...
July 26, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28745387/clinical-and-psychosocial-characterization-of-at-risk-mental-state-and-recent-onset-psychosis-patients-from-an-early-psychosis-program-in-barcelona-spain
#14
Tecelli Domínguez-Martínez, Paula Cristóbal-Narváez, Thomas R Kwapil, Neus Barrantes-Vidal
INTRODUCTION: This study aimed to describe and compare socio-demographic, background, treatment history, and service use, psychopathological and psychosocial characteristics of At-Risk Mental States (ARMS) and First-Episode Psychosis (FEP) patients from the Sant Pere Claver-Early Psychosis Program (SPC-EPP) in Barcelona. METHODS: 43 ARMS-patients and 40 FEP-patients were assessed with several clinical and psychosocial measures at study baseline. RESULTS: Clinical and psychosocial characteristics of the SPC-EPP sample were comparable to those of previous early psychosis studies...
July 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28738349/towards-an-integrated-view-of-early-molecular-changes-underlying-vulnerability-to-social-stress-in-psychosis
#15
Henry Barron, Sina Hafizi, Romina Mizrahi
Psychotic disorders are heterogeneous and complex, involving many putative causal factors interacting along the course of disease development. Many of the factors implicated in the pathogenesis of psychosis also appear to be involved in disease onset and subsequent neuroprogression. Herein, we highlight the pertinent literature implicating inflammation and oxidative stress in the pathogenesis of psychosis, and the potential contribution of N-methyl-D-aspartate receptors (NMDARs). We also emphasize the role of peripubertal social stress in psychosis, and the ways in which hippocampal dysfunction can mediate dysregulation of the hypothalamic-pituitary-adrenal axis and cortisol release...
2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28728091/age-at-the-time-of-onset-of-psychosis-a-marker-of-specific-needs-rather-than-a-determinant-of-outcome
#16
P Golay, L Alameda, N Mebdouhi, P Baumann, C Ferrari, A Solida, P Progin, J Elowe, P Conus
BACKGROUND: While there is suggestion that early onset of psychosis is a determinant of outcome; knowledge regarding correlates of later onset age is more limited. This study explores the characteristics of patients developing psychosis after age 26, towards the end of the usual age range of early intervention programs, in order to identify potential specific needs of such patients. METHODS: Two hundred and fifty-six early psychosis patients aged 18-35 were followed-up prospectively over 36 months...
June 21, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28723956/psychosis-risk-research-versus-daily-prognosis-uncertainties-a-qualitative-study-of-french-youth-psychiatrists-attitudes-toward-predictive-practices
#17
Laelia Benoit, Marie Rose Moro, Bruno Falissard, Nicolas Henckes
BACKGROUND: Over the last twenty years, predicting psychosis has become a priority of both research and policies. Those approaches include the use of the At Risk Mental State category (ARMS) and of standardized predictive tools. In comparison to most developed countries, early interventions programs are only little developed in France. However, cases of young patients presenting unclear symptoms that might be a beginning psychosis or might as well reflect some adolescent unease are commonplace in psychiatry...
2017: PloS One
https://www.readbyqxmd.com/read/28719151/staged-treatment-in-early-psychosis-a-sequential-multiple-assignment-randomised-trial-of-interventions-for-ultra-high-risk-of-psychosis-patients
#18
REVIEW
Barnaby Nelson, G Paul Amminger, Hok Pan Yuen, Nicky Wallis, Melissa J Kerr, Lisa Dixon, Cameron Carter, Rachel Loewy, Tara A Niendam, Martha Shumway, Sarah Morris, Julie Blasioli, Patrick D McGorry
AIM: Previous research indicates that preventive intervention is likely to benefit patients "at risk" of psychosis, in terms of functional improvement, symptom reduction and delay or prevention of onset of threshold psychotic disorder. The primary aim of the current study is to test outcomes of ultra high risk (UHR) patients, primarily functional outcome, in response to a sequential intervention strategy consisting of support and problem solving (SPS), cognitive-behavioural case management and antidepressant medication...
July 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28707138/gray-matter-changes-and-cognitive-predictors-of-2-year-follow-up-abnormalities-in-early-onset-first-episode-psychosis
#19
Josefina Castro-Fornieles, Nuria Bargalló, Anna Calvo, Celso Arango, Immaculada Baeza, Ana Gonzalez-Pinto, Mara Parellada, Montserrat Graell, Carmen Moreno, Soraya Otero, Joost Janssen, Marta Rapado-Castro, Elena de la Serna
This study aims to examine regional gray matter (GM) changes over a period of 2 years in patients diagnosed with early-onset first-episode psychosis (EO-FEP), and to identify baseline predictors of abnormalities at the follow-up. Fifty-nine patients with EO-FEP aged 11-17 years were assessed. Magnetic resonance imaging was carried out at admission and 2 years later. Changes over time were assessed with voxel-based morphometry. Fifty-nine patients (34 schizophrenia-SCZ, 15 bipolar disorder-BP, and 10 other psychotic disorders) and 70 healthy controls were assessed...
July 13, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28689474/a-qualitative-phenomenological-analysis-of-the-subjective-experience-and-understanding-of-the-at-risk-mental-state
#20
Benjamin Brew, Ciaran Shannon, Lesley Storey, Adrian Boyd, Ciaran Mulholland
Over recent years there has been a growing interest in identifying the early stages of psychosis. The At Risk Mental State (ARMS) is characteristic of the prodromal stages of psychosis and its identification gives rise to a number of clinical and research opportunities including early intervention and prevention of psychosis. This study employs interpretative phenomenological analysis to gain insights into the subjective experience and individuals understanding of the development of their ARMS. Five participants took part and provided information on the experience of symptoms, life prior to onset of their ARMS and their understanding of symptoms and their development through a semi structured interview...
December 2017: International Journal of Qualitative Studies on Health and Well-being
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