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Early onset psychosis

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https://www.readbyqxmd.com/read/29148264/negative-symptoms-in-first-episode-psychosis-clinical-correlates-and-1-year-follow-up-outcomes-in-london-early-intervention-services
#1
Aikaterini Rammou, Helen L Fisher, Sonia Johnson, Barnaby Major, Nikola Rahaman, Nick Chamberlain-Kent, James M Stone
AIM: Negative symptoms (NS) have been associated with poor outcome and remain difficult to treat in patients with psychosis. This study examined the association of NS with clinical features at first presentation to mental health services for psychosis and with outcomes at 1-year follow-up. METHODS: Clinical data were utilized from five London Early Intervention Services (EIS) included in the MiData audit database. The sample comprised 484 first-episode psychosis patients with complete Positive and Negative Syndrome Scale data at baseline and 1-year follow-up...
November 16, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29143717/white-matter-abnormalities-in-22q11-2-deletion-syndrome-patients-showing-cognitive-decline
#2
Jasper Olivier Nuninga, Marc Marijn Bohlken, Sanne Koops, Ania M Fiksinski, René C W Mandl, Elemi J Breetvelt, Sasja N Duijff, René S Kahn, Iris E C Sommer, Jacob A S Vorstman
BACKGROUND: Decline in cognitive functioning precedes the first psychotic episode in the course of schizophrenia and is considered a hallmark symptom of the disorder. Given the low incidence of schizophrenia, it remains a challenge to investigate whether cognitive decline coincides with disease-related changes in brain structure, such as white matter abnormalities. The 22q11.2 deletion syndrome (22q11DS) is an appealing model in this context, as 25% of patients develop psychosis. Furthermore, we recently showed that cognitive decline also precedes the onset of psychosis in individuals with 22q11DS...
November 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29128195/-what-support-of-young-presenting-a-first-psychotic-episode-when-schooling-is-being-challenged
#3
M-N Vacheron, H Veyrat-Masson, E Wehbe
Psychiatric disorders (more specifically mood disorders and psychosis) represent the 1st cause of disability among young people. Unemployment rate between 75 to 95% for the person with schizophrenia. It is correlated to poor social integration and bad economic status, worse symptomatology loss of autonomy as well as global bad functioning. It is responsible of more than half of the overall cost of psychosis. The onset of most of psychiatric disorders occur between the age of 25 and 35 years old, a critical time in young adult life when they should build their professional as well as social future...
November 8, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29125721/the-association-between-comorbid-autism-spectrum-disorders-and-antipsychotic-treatment-failure-in-early-onset-psychosis-a-historical-cohort-study-using-electronic-health-records
#4
Johnny M Downs, Suzannah Lechler, Harry Dean, Nicola Sears, Rashmi Patel, Hitesh Shetty, Emily Simonoff, Matthew Hotopf, Tamsin J Ford, Covadonga M Diaz-Caneja, Celso Arango, James H MacCabe, Richard D Hayes, Laura Pina-Camacho
OBJECTIVE: In a sample of children and adolescents with first-episode psychosis, we investigated whether multiple treatment failure (MTF, defined as the initiation of a third trial of novel antipsychotic due to nonadherence, adverse effects, or insufficient response) was associated with comorbid autism spectrum disorders. METHODS: Data were from the electronic health records of 638 children (51% male) aged from 10 to 17 years with first-episode psychosis (per ICD-10 criteria) from January 1, 2008, to November 1, 2014, referred to mental health services in South London, United Kingdom; data were extracted using the Clinical Record Interactive Search (CRIS) system...
November 7, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29121595/from-the-psychosis-prodrome-to-the-first-episode-of-psychosis-no-evidence-of-a-cognitive-decline
#5
Ricardo E Carrión, Deborah J Walder, Andrea M Auther, Danielle McLaughlin, Heather O Zyla, Steven Adelsheim, Roderick Calkins, Cameron S Carter, Bentson McFarland, Ryan Melton, Tara Niendam, J Daniel Ragland, Tamara G Sale, Stephan F Taylor, William R McFarlane, Barbara A Cornblatt
Cognitive deficits have an important role in the neurodevelopment of schizophrenia and other psychotic disorders. However, there is a continuing debate as to whether cognitive impairments in the psychosis prodrome are stable predictors of eventual psychosis or undergo a decline due to the onset of psychosis. In the present study, to determine how cognition changes as illness emerges, we examined baseline neurocognitive performance in a large sample of helping-seeking youth ranging in clinical state from low-risk for psychosis through individuals at clinical high-risk (CHR) for illness to early first-episode patients (EFEP)...
October 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29116582/late-onset-first-episode-psychosis-emerging-as-delusional-misidentification-of-familiar-sacred-places-during-a-holy-pilgrimage-a-case-report-and-literature-review
#6
Mahmoud A Awara, Hamdy F Moselhy, Manal O Elnenaei
BACKGROUND: The delusional misidentification syndromes (DMS) include a myriad of discrete but related syndromes, which have wide spectrum anomalies of familiarity. Several misidentification syndromes have been described in the psychiatric literature, the most common of these delusions are: the Capgras syndrome; the Fregoli syndrome; the syndrome of inter-metamorphosis; reduplicative paramnesia; and environmental reduplication. CASE PRESENTATION: The reported case highlights the emergence of late onset first episode psychosis in a Middle Eastern 65-year-old female who has no previous psychiatric history...
November 7, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/29106788/early-onset-inguinal-hernia-as-risk-factor-for-schizophrenia-or-related-psychosis-a-nationwide-register-based-cohort-study
#7
(no author information available yet)
OBJECTIVES: In an earlier interview study, we found that more men with familial schizophrenia had undergone inguinal hernia operation, than men with sporadic schizophrenia. However, there are no other studies published specifically on inguinal hernia and schizophrenia. Therefore, the aim of this study was to carry out a Swedish register-based cohort study on the association between inguinal hernia and schizophrenia or related psychosis. METHODS: Data from the Total Population- and Medical Birth-Registers were used to create a cohort of all individuals born in Sweden 1987-1999 (n=1 406 168)...
October 6, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29096386/cannabis-induced-psychosis-and-subsequent-psychiatric-disorders
#8
Dharav Shah, Prabhat Chand, Mrunal Bandawar, Vivek Benegal, Pratima Murthy
INTRODUCTION: Long term change in diagnosis of patients having Cannabis induced psychosis (CIP) at the index evaluation is well recognised. Some patients are known to achieve complete remission while others go on to develop independent schizophrenia or mood disorders. AIMS: To study the long-term course of CIP and factors influencing it. METHOD: Patients diagnosed as CIP (ICD 10: F12.5), admitted at NIMHANS, a tertiary neuropsychiatry centre at Bangalore, over the past 10 years were identified from medical records...
October 16, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29096206/risk-factors-in-early-and-late-onset-schizophrenia
#9
Laura Chen, Ajit Selvendra, Anne Stewart, David Castle
BACKGROUND: This study looks at key risk factors in patients with schizophrenia to identify trends according to age of onset, comparing presentations prior to 26years (youth onset), between 26 and 40years (middle onset), and after 40years of age (late onset). METHODS: The early psychosis program at St Vincent's Hospital Melbourne treats patients presenting in the early stages of psychosis between 16 and 65years of age. A database was developed to capture key risk factors in all patients with an eventual diagnosis of schizophrenia (n=225)...
September 20, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29092669/the-clinical-impact-of-a-positive-family-history-of-psychosis-or-mental-illness-in-psychotic-and-non-psychotic-mentally-ill-adolescents
#10
Saeeda Paruk, Khatija Jhazbhay, Keshika Singh, Benn Sartorius, Jonathan K Burns
BACKGROUND: A family history of psychosis is associated with negative clinical characteristics of psychosis. AIM: We aimed to determine the relationship between a family history (in first-degree relatives) of psychosis (FHP) or of any mental illness (FHM), and the clinical features (including cannabis use) of first episode early onset psychosis (EOP). METHOD: Forty-five adolescents with first episode EOP presenting to psychiatric services were assessed by clinical interview with the following tools: socio-demographic questionnaire, Positive and Negative Syndrome Scale (PANSS), Symptom Onset in Schizophrenia (SOS) inventory, and the World Health Organisation's (WHO) Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) for cannabis misuse...
November 2, 2017: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/29083450/the-potential-of-cannabidiol-treatment-for-cannabis-users-with-recent-onset-psychosis
#11
Britta Hahn
A major factor associated with poor prognostic outcome after a first psychotic break is cannabis misuse, which is prevalent in schizophrenia and particularly common in individuals with recent-onset psychosis. Behavioral interventions aimed at reducing cannabis use have been unsuccessful in this population. Cannabidiol (CBD) is a phytocannabinoid found in cannabis, although at low concentrations in modern-day strains. CBD has a broad pharmacological profile, but contrary to ∆9-tetrahydrocannabinol (THC), CBD does not activate CB1 or CB2 receptors and has at most subtle subjective effects...
August 11, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29074331/intra-individual-variability-and-psychotic-like-experiences-in-adolescents-findings-from-the-alspac-cohort
#12
Simon Wallace, Richard J Linscott
Clinical and epidemiological studies have demonstrated associations between elevated intra-individual variability (IIV) of reaction time and psychotic disorders. However, little attention has been paid to the relationship between performance stability and psychotic-like experiences (PLE) in adolescence, before psychotic disorder onset. Data from 6702 children from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to address this issue. Children took part in a semi-structured clinical interview regarding psychotic symptoms at age 12 and 18, and reaction time variability was assessed at age 13 and 15...
October 24, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29073635/huntington-s-disease-premotor-phase
#13
Ana Rita Saldanha Ramos, Carolina Garrett
Huntington's disease (HD) is an incurable, neurodegenerative disease, which manifests via a triad of progressive symptoms: motor impairment, psychiatric disorders, and cognitive decline. Conventionally, the HD diagnosis is based on the presence of involuntary choreiform movements and a positive genetic test for the CAG-expanded allele gene. Although the diagnosis focuses on the motor part of the triad, there is increasing evidence that both cognitive and neuropsychiatric symptoms can, and often do, present decades before the onset of motor symptoms...
October 27, 2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29072182/social-challenges-of-contemporary-psychiatry
#14
N Bouras
Psychiatry and society are interrelated and the biopsychosocial model continues to dominate the clinical psychiatric practice. Some doubts have been expressed in recent years about the value and the wide acceptance of the biopsychosocial model. Ghaemi (2009)1 considers it to be anti-humanistic and advocates the use of less eclectic, less generic, and less vague alternatives. The fundamental changes that have been witnessed in our times across the spectrum of biology, psychology and sociology have made necessary that a conceptual clarity should prevail...
July 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29055258/cognitive-functioning-in-first-episode-bipolar-i-disorder-patients-with-and-without-history-of-psychosis
#15
Chakrabarty Trisha, Alamian Golnoush, Kozicky Jan-Marie, Ivan J Torres, Lakshmi N Yatham
BACKGROUND: Psychosis in bipolar I disorder (BDI) has been associated with increased cognitive dysfunction, which may relate to poorer functional outcomes. However, it is not known whether cognition differs between BDI patients with (BDP+) or without (BDP-) history of psychosis early in the disease course, or if it is impacted by the presence of mood congruent (MCP) versus incongruent (MIC) psychotic features. We compare cognition between these groups in BDI patients recently recovered from first episode of mania...
October 2, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29052952/factor-structure-of-the-cannabis-experiences-questionnaire-in-a-first-episode-psychosis-sample
#16
Michael L Birnbaum, Sean D Cleary, Claire Ramsay Wan, Luca Pauselli, Michael T Compton
AIM: The Cannabis Experiences Questionnaire (CEQ) was developed to measure the subjective experiences of cannabis use both during and after intoxication. Despite the need to better understand the nature of the complex and significant relationship between cannabis use and early psychosis, this questionnaire has rarely been used in individuals with first-episode psychosis. METHODS: We conducted a set of factor analyses using CEQ data from 194 first-episode psychosis patients who used cannabis in order to uncover the underlying factor structure of the questionnaire and thus the overarching types of psychological experiences during/after using cannabis in young people with psychotic disorders...
October 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29048724/longitudinal-perspectives-on-the-psychosis-spectrum-in-22q11-2-deletion-syndrome
#17
REVIEW
Sunny X Tang, Raquel E Gur
The prevalence of psychotic disorders in individuals with 22q11.2 Deletion Syndrome (22q11DS) reaches 25-35% in young adulthood and may provide a neurogenetic model for clinical risk of psychotic disorders in the general population. This review focuses on prospective longitudinal studies in 22q11DS, which capture fluctuations in psychosis symptoms over time and may provide insights into potential demographic, clinical, cognitive, and neuroimaging predictors of psychosis-spectrum outcomes in the general population...
October 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29034144/exercise-treatments-for-psychosis-a-review
#18
Vijay A Mittal, Teresa Vargas, K Juston Osborne, Derek Dean, Tina Gupta, Ivanka Ristanovic, Christine I Hooker, Stewart A Shankman
Schizophrenia is a devastating mental illness that has profound effects on a person's health and quality of life. Exercise represents a promising new treatment option that may supplement current psychosocial and pharmacological interventions for psychosis. A large body of work suggests that exercise can improve cardio-metabolic and health behavior and facilitate neurogenesis in areas of the brain that are notably impacted by psychosis. Recent efforts to incorporate exercise as either stand-alone or adjunctive treatment for individuals with schizophrenia range from yoga and light stretching to moderately intense walking, bike riding, or team sports...
June 2017: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/29018160/dopamine-dysregulation-syndrome-in-parkinson-s-disease-a-systematic-review-of-published-cases
#19
Nicola Warren, Cullen O'Gorman, Alexander Lehn, Dan Siskind
OBJECTIVES: Dopamine dysregulation syndrome (DDS) is an uncommon complication of the treatment of Parkinson's disease, characterised by addictive behaviour and excessive use of dopaminergic medication. DDS may frequently go unrecognised or misdiagnosed. We aimed to clarify current understanding of presentation, risk factors, comorbidities and management of DDS. METHODS: Case reports were identified through a systematic search of databases (PubMed, Embase) with the following terms: dopaminergic dysregulation syndrome, hedonistic homeostatic dysregulation, dopamine/levodopa addiction...
October 10, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28986006/association-between-mismatch-negativity-and-global-functioning-is-specific-to-duration-deviance-in-early-stages-of-psychosis
#20
Daisuke Koshiyama, Kenji Kirihara, Mariko Tada, Tatsuya Nagai, Mao Fujioka, Shinsuke Koike, Motomu Suga, Tsuyoshi Araki, Kiyoto Kasai
BACKGROUND: Mismatch negativity (MMN) is a candidate biomarker for early stages of psychosis. Although an association among duration MMN (dMMN), cognitive deficits, and functional outcome in chronic schizophrenia has been shown by a large-scale study, the effects of deviant type and clinical stages have not been investigated. METHODS: We investigated the relationships among dMMN, frequency MMN (fMMN), global functioning, and cognitive function in early stages of psychosis...
October 3, 2017: Schizophrenia Research
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