keyword
https://read.qxmd.com/read/38534919/review-on-the-role-of-brca-mutations-in-genomic-screening-and-risk-stratification-of-prostate-cancer
#1
REVIEW
Nikolaos Kalampokis, Christos Zabaftis, Theodoros Spinos, Markos Karavitakis, Ioannis Leotsakos, Ioannis Katafigiotis, Henk van der Poel, Nikolaos Grivas, Dionysios Mitropoulos
(1) Background: Somatic and germline alterations can be commonly found in prostate cancer (PCa) patients. The aim of our present study was to perform a comprehensive review of the current literature in order to examine the impact of BRCA mutations in the context of PCa as well as their significance as genetic biomarkers. (2) Methods: A narrative review of all the available literature was performed. Only "landmark" publications were included. (3) Results: Overall, the number of PCa patients who harbor a BRCA2 mutation range between 1...
February 22, 2024: Current Oncology
https://read.qxmd.com/read/38534761/genetic-signatures-for-distinguishing-chemo-sensitive-from-chemo-resistant-responders-in-prostate-cancer-patients
#2
JOURNAL ARTICLE
Lemohang Gumenku, Mamello Sekhoacha, Beynon Abrahams, Samson Mashele, Aubrey Shoko, Ochuko L Erukainure
Prostate cancer remains a significant public health concern in sub-Saharan Africa, particularly impacting South Africa with high mortality rates. Despite many years of extensive research and significant financial expenditure, there has yet to be a definitive solution to prostate cancer. It is not just individuals who vary in their response to treatment, but even different nodules within the same tumor exhibit unique transcriptome patterns. These distinctions extend beyond mere differences in gene expression levels to encompass the control and networking of individual genes...
March 11, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533063/predictive-value-of-procollagen-c-protease-enhancer-protein-on-the-prognosis-of-glioma-patients
#3
JOURNAL ARTICLE
Luli Yu, Xinyao Hu, Hua Zhu
Procollagen c-protease enhancer protein (PCOLCE) performs an essential action in improving the recreation of procollagen c-protease and promoting the reconstruction of extracellular matrix. High PCOLCE expression was associated with a negative prognosis of stomach cancer, ovarian cancer, and osteosarcoma. The goal of this work is to investigate the function of PCOLCE in glioma. Multiple bioinformatics techniques have been employed to investigate the roles of PCOLCE in glioma, consisting of the correlation between PCOLCE and prognosis, immune checkpoints, immune cell infiltrates, and tumor microenvironment (TME)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38531804/investigating-the-spatial-distribution-of-proliferating-cells-in-primary-ovarian-cancers
#4
JOURNAL ARTICLE
Mohamed A A A Hegazi, Fabio Pasqualini, Gianluigi Taverna, Robert S Bresalier, Maurizio Chiriva-Internati, Fabio Grizzi
BACKGROUND: Ovarian cancer (OC) accounts for about 4% of female cancers globally. While Ki67-immunopositive (Ki67+ ) cell density is commonly used to assess proliferation in OC, the two-dimensional (2D) distribution pattern of these cells is poorly understood. This study explores the 2D distribution pattern of Ki67+ cells in primary OC tissues and models the proliferation process to improve our understanding of this hallmark of cancer. METHODS: A total of 100 tissue cores, included in a tissue microarray (TMA) representing 5 clear cell carcinomas, 62 serous carcinomas, 10 mucinous adenocarcinomas, 3 endometrioid adenocarcinomas, 10 lymph node metastases from OC, and 10 samples of adjacent normal ovary tissue, were stained using a standardized immunohistochemical protocol...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38529390/a-lactate-metabolism-related-signature-predicting-patient-prognosis-and-immune-microenvironment-in-ovarian-cancer
#5
JOURNAL ARTICLE
Linhua Zhu, Zhuoqun Lin, Kai Wang, Jiaxin Gu, Xiaojing Chen, Ruizhe Chen, Lingfang Wang, Xiaodong Cheng
INTRODUCTION: Ovarian cancer (OV) is a highly lethal gynecological malignancy with a poor prognosis. Lactate metabolism is crucial for tumor cell survival, proliferation, and immune evasion. Our study aims to investigate the role of lactate metabolism-related genes (LMRGs) in OV and their potential as biomarkers for prognosis, immune microenvironment, and immunotherapy response. METHODS: Ovarian samples were collected from the TCGA cohort. And 12 lactate-related pathways were identified from the MsigDB database...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38528610/metastasis-of-serous-ovarian-carcinoma-to-the-breast-a-case-report-and-review-of-the-literature
#6
REVIEW
Sofia Dueño, Rachel Stein, Mohsin Jamal, Gregory Lewis, Karina Hew
BACKGROUND: Breast metastasis from primary ovarian cancer is rare, with an estimated frequency of 0.07%. More than 110 cases are reported in the literature of metastatic spread of ovarian cancer to the breast and axilla. This entity usually represents aggressive late disease characterized by multi-drug chemoresistance and a poor prognosis with a median survival time of 16 months. Currently no standardized treatment protocol exists for this condition. CASE PRESENTATION: We present a case of a 59-year-old Caucasian female with recurrent high-grade serous ovarian cancer who was diagnosed with symptomatic unilateral breast metastasis while on fourth line chemotherapy with weekly paclitaxel...
March 26, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38516424/optimizing-in-vitro-fertilization-ivf-success-in-hypergonadotropic-hypogonadism-a-case-study-on-the-impact-of-the-shanghai-protocol
#7
Rokaiya Shaikh, Akash More, Shilpa Dutta, Namrata Choudhary, Jarul Shrivastava, Al Hera Ansari, Gauri Gajabe
This article evaluated the effect of the Shanghai protocol on a hypergonadotropic hypogonadism patient undergoing in vitro fertilization (IVF) treatment. Hypergonadotropic hypogonadism was characterized by low sex hormone levels and elevated gonadotropins, leading to infertility. Poor ovarian response and failed pregnancy outcomes were the results of previous IVF treatments using conventional stimulation methods. The 37-year-old female patient was advised to follow the Shanghai protocol, which involved gonadotropin stimulation following pituitary suppression with a long-acting gonadotropin-releasing hormone agonist (GnRH-a)...
February 2024: Curēus
https://read.qxmd.com/read/38514660/tertiary-lymphoid-structures-and-b-cells-determine-clinically-relevant-t-cell-phenotypes-in-ovarian-cancer
#8
JOURNAL ARTICLE
Lenka Kasikova, Jana Rakova, Michal Hensler, Tereza Lanickova, Jana Tomankova, Josef Pasulka, Jana Drozenova, Katerina Mojzisova, Anna Fialova, Sarka Vosahlikova, Jan Laco, Ales Ryska, Pavel Dundr, Roman Kocian, Tomas Brtnicky, Petr Skapa, Linda Capkova, Marek Kovar, Jan Prochazka, Ivan Praznovec, Vladimir Koblizek, Alice Taskova, Hisashi Tanaka, Robert Lischke, Fernando Casas Mendez, Jiri Vachtenheim, Viola Heinzelmann-Schwarz, Francis Jacob, Iain A McNeish, Michal J Halaska, Lukas Rob, David Cibula, Sandra Orsulic, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova
Intratumoral tertiary lymphoid structures (TLSs) have been associated with improved outcome in various cohorts of patients with cancer, reflecting their contribution to the development of tumor-targeting immunity. Here, we demonstrate that high-grade serous ovarian carcinoma (HGSOC) contains distinct immune aggregates with varying degrees of organization and maturation. Specifically, mature TLSs (mTLS) as forming only in 16% of HGSOCs with relatively elevated tumor mutational burden (TMB) are associated with an increased intratumoral density of CD8+ effector T (TEFF ) cells and TIM3+ PD1+ , hence poorly immune checkpoint inhibitor (ICI)-sensitive, CD8+ T cells...
March 21, 2024: Nature Communications
https://read.qxmd.com/read/38505752/development-and-validation-of-a-prediction-model-for-unexpected-poor-ovarian-response-during-ivf-icsi
#9
JOURNAL ARTICLE
Xiaohang Xu, Xue Wang, Yilin Jiang, Haoyue Sun, Yuanhui Chen, Cuilian Zhang
BACKGROUND: Identifying poor ovarian response (POR) among patients with good ovarian reserve poses a significant challenge within reproductive medicine. Currently, there is a lack of published data on the potential risk factors that could predict the occurrence of unexpected POR. The objective of this study was to develop a predictive model to assess the individual probability of unexpected POR during in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatments. METHODS: The development of the nomogram involved a cohort of 10,404 patients with normal ovarian reserve [age, ≤40 years; antral follicle count (AFC), ≥5; and anti-Müllerian hormone (AMH), ≥1...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38494342/association-between-body-mass-index-and-in-vitro-fertilization-intra-cytoplasmic-sperm-injection-outcomes-an-analysis-of-15-124-normal-ovarian-responders-in-china
#10
JOURNAL ARTICLE
Danlei Zheng, Yuanyuan Wang, Lixue Chen, Lin Zeng, Rong Li
BACKGROUND: High body mass index (BMI) results in decreased fecundity, and women with high BMI have reduced rates of clinical pregnancy and live birth in in vitro fertilization/intra-cytoplasmic sperm injection (IVF/ICSI). Meanwhile, ovarian responses show great heterogeneity in patients with a high BMI. This study aimed to analyze the effects of a high BMI on IVF/ICSI outcomes in the Chinese female with normal ovarian response. METHODS: We performed a retrospective cohort study comprising 15,124 patients from the medical record system of the Reproductive Center of Peking University Third Hospital, with 3530 (23...
March 18, 2024: Chinese Medical Journal
https://read.qxmd.com/read/38492533/potential-tools-for-predicting-response-to-chemotherapy-in-oc-assessment-of-immune-dysbiosis-participant-s-self-rated-health-and-microbial-dynamics
#11
JOURNAL ARTICLE
Taylor Badger, Elizabeth Anderson, Sarah Nelson, Kathleen Groesch, Teresa Wilson, Paula Diaz-Sylvester, Kristin Delfino, Nhung Le, Laurent Brard, Andrea Braundmeier-Fleming
Epithelial ovarian cancer (OC) is the deadliest female reproductive cancer; an estimated 13,270 women will die from OC in 2023. Platinum-based chemotherapy resistance mechanisms contribute to poor OC 5-year survival rates. Peripheral inflammation is linked to various disease states and we previously identified unique peritoneal microbial features predictive of OC. We hypothesized that unique peripheral immune profiles and peritoneal microbial features may be predictive of disease-free interval (time to recurrence) and response to chemotherapy in participants with OC...
March 12, 2024: Journal of Reproductive Immunology
https://read.qxmd.com/read/38485316/autophagy-activity-is-increased-in-the-cumulus-cells-of-women-with-poor-ovarian-response
#12
JOURNAL ARTICLE
Jie-Ru Zhu, Wei-Jie Zhu, Tao Li, Jian-Ping Ou
OBJECTIVE: To evaluate the autophagy status of cumulus cells (CCs) in women with poor ovarian response (POR). MATERIALS AND METHODS: CCs were divided into normal ovarian response (NOR) group and POR group. The ultrastructure of autophagy was analyzed by transmission electron microscopy (NOR: n = 18, POR: n = 26). The mRNA and protein of autophagy markers were detected by Quantitative real-time polymerase chain reaction (NOR: n = 15, POR: n = 19) and Western blotting (NOR: n = 41, POR: n = 38), respectively...
March 2024: Taiwanese Journal of Obstetrics & Gynecology
https://read.qxmd.com/read/38485315/comparison-of-miscarriage-rates-in-low-prognosis-patients-according-to-the-poseidon-criteria
#13
JOURNAL ARTICLE
Yu-Yang Hsiao, Ni-Chin Tsai, Yu-Ting Su, Yu-Ju Lin, Hsin-Ju Chiang, Fu-Tsai Kung, Kuo-Chung Lan
OBJECTIVE: The POSEIDON criteria stratified patients with poor ovarian response into four subgroups with exclusive characteristics and assisted reproductive technology success rates. However, limited studies focused on miscarriage in the POSEIDON population. This study aimed to explore whether the miscarriage rate different among low prognosis patients according to POSEIDON criteria. MATERIALS AND METHODS: This is a retrospective observational study. All clinical pregnancies achieved after in vitro fertilization or intracytoplasmic sperm injection treatment between January 1998 and April 2021 were analyzed...
March 2024: Taiwanese Journal of Obstetrics & Gynecology
https://read.qxmd.com/read/38472557/a-signature-of-circulating-mirnas-predicts-the-prognosis-and-therapeutic-outcome-of-taxane-platinum-regimen-in-advanced-ovarian-carcinoma-patients
#14
JOURNAL ARTICLE
Ranita Pal, Trisha Choudhury, Madhurima Ghosh, Manisha Vernakar, Partha Nath, Vilas Deorao Nasare
PURPOSE: Ovarian carcinoma (OC) is ranked as the eighth most lethal gynecological cancer due to late diagnosis and high recurrence. Existing biomarkers are lacking to predict the recurrence and stratify patients who are likely to benefit from chemotherapy. MicroRNAs (miRNAs/miRs) are persistently present in humans and are capable of predicting treatment outcomes. Thus, the purpose of the study was to assess the potential of circulatory miRNAs to predict the efficacy of OC. METHODS: Newly diagnosed n = 208 OC patients were administrated neoadjuvant/adjuvant chemotherapy (taxane + platinum) after surgery...
March 12, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38471508/phase-1b-study-of-intraperitoneal-ipilimumab-and-nivolumab-in-patients-with-recurrent-gynecologic-malignancies-with-peritoneal-carcinomatosis
#15
JOURNAL ARTICLE
Anne Knisely, Emily Hinchcliff, Bryan Fellman, Ann Mosley, Kathryn Lito, Sara Hull, Shannon N Westin, Anil K Sood, Kathleen M Schmeler, Jolyn S Taylor, Steven Y Huang, Rahul A Sheth, Karen H Lu, Amir A Jazaeri
BACKGROUND: Intravenous immune checkpoint blockade (ICB) has shown poor response rates in recurrent gynecologic malignancies. Intraperitoneal (i.p.) ICB may result in enhanced T cell activation and anti-tumor immunity. METHODS: In this phase 1b study, registered at Clinical. TRIALS: gov (NCT03508570), initial cohorts received i.p. nivolumab monotherapy, and subsequent cohorts received combination i.p. nivolumab every 2 weeks and i...
March 7, 2024: Med
https://read.qxmd.com/read/38459814/genomic-alterations-in-ovarian-endometriosis-and-subsequently-diagnosed-ovarian-carcinoma
#16
JOURNAL ARTICLE
A Linder, S Westbom-Fremer, C Mateoiu, A Olsson Widjaja, T Österlund, S Veerla, A Ståhlberg, B Ulfenborg, I Hedenfalk, K Sundfeldt
STUDY QUESTION: Can the alleged association between ovarian endometriosis and ovarian carcinoma be substantiated by genetic analysis of endometriosis diagnosed prior to the onset of the carcinoma? SUMMARY ANSWER: The data suggest that ovarian carcinoma does not originate from ovarian endometriosis with a cancer-like genetic profile; however, a common precursor is probable. WHAT IS KNOWN ALREADY: Endometriosis has been implicated as a precursor of ovarian carcinoma based on epidemiologic studies and the discovery of common driver mutations in synchronous disease at the time of surgery...
March 9, 2024: Human Reproduction
https://read.qxmd.com/read/38452353/risk-factors-for-poor-oocyte-yield-and-oocyte-immaturity-after-gnrh-agonist-triggering
#17
JOURNAL ARTICLE
S Gambini, C Sonigo, G Robin, I Cedrin-Durnerin, C Vinolas, C Sifer, Y Boumerdassi, A Mayeur, V Gallot, M Grynberg, M Peigné
STUDY QUESTION: What are the potential risk factors for poor oocyte recuperation rate (ORR) and oocyte immaturity after GnRH agonist (GnRHa) ovulation triggering? SUMMARY ANSWER: Lower ovarian reserve and LH levels after GnRHa triggering are risk factors of poor ORR. Higher BMI and anti-Müllerian hormone (AMH) levels are risk factors of poor oocyte maturation rate (OMR). WHAT IS KNOWN ALREADY: The use of GnRHa to trigger ovulation is increasing...
March 7, 2024: Human Reproduction
https://read.qxmd.com/read/38436697/apurinic-apyrimidinic-endodeoxyribonuclease-1-ape1-promotes-stress-granule-formation-via-ybx1-phosphorylation-in-ovarian-cancer
#18
JOURNAL ARTICLE
Shuyu Mao, Chong Xie, Yufeng Liu, Ye Zhao, Mengxia Li, Han Gao, Yue Xiao, Yongkang Zou, Zhiguo Zheng, Ya Gao, Juan Xie, Bing Tian, Liangyan Wang, Yuejin Hua, Hong Xu
APE1 is an essential gene involved in DNA damage repair, the redox regulation of transcriptional factors (TFs) and RNA processing. APE1 overexpression is common in cancers and correlates with poor patient survival. Stress granules (SGs) are phase-separated cytoplasmic assemblies that cells form in response to environmental stresses. Precise regulation of SGs is pivotal to cell survival, whereas their dysregulation is increasingly linked to diseases. Whether APE1 engages in modulating SG dynamics is worthy of investigation...
March 4, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38436182/age-and-dual-trigger-were-found-to-be-significant-predictors-of-live-birth-in-poseidon-group-3-and-4-women-treated-with-the-gnrh-antagonist-protocol-a-retrospective-cohort-study
#19
JOURNAL ARTICLE
B Varlı, Y E Sukur, B Ozmen, M Sönmezer, C Atabekoğlu, R Aytaç, B Berker
OBJECTIVE: Despite recent advancements in assisted reproductive technology (ART), the effective management of patients with poor ovarian response (POR) remains a formidable challenge. While various treatment strategies and predictors of live births have been documented to provide guidance to fertility specialists in managing poor responders, research efforts have predominantly encompassed all POSEIDON groups. In this study, our objective was to analyze the factors correlated with live births (LB) within a subset of the POSEIDON groups, with a particular focus on POSEIDON groups 3 and 4...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38433576/abrogation-of-klf5-sensitizes-brca1-proficient-pancreatic-cancer-to-parp-inhibition
#20
JOURNAL ARTICLE
Zheng Zhang, Yuxin Liu, Yaolin Xu, Zijin Xu, Jinbin Jia, Yun Jin, Wenquan Wang, Liang Liu
Poly ADP-ribose polymerase (PARP) inhibitor monotherapies are selectively effective in patients with pancreatic, breast, prostate, and ovarian cancers with BRCA1 mutations. Cancer patients with more frequent wild-type BRCA show poor responses to PARP inhibitors. Moreover, patients who are initially sensitive to these inhibitors eventually respond poorly to drugs. In the present study, we discover that abrogation of Kruppel-like factor 5 (KLF5) significantly inhibits homologous recombination, which is the main mechanism for DNA double-stranded repair...
March 4, 2024: Acta Biochimica et Biophysica Sinica
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