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https://www.readbyqxmd.com/read/28229422/therapeutic-application-of-adult-stem-cells-in-the-heart
#1
Taylor A Johnson, Dinender K Singla
Cell therapies have been explored as a potential treatment avenue to treat heart diseases, such as myocardial infarction, doxorubicin-induced cardiomyopathy, and heart failure. Embryonic and adult stem cells (ASCs) have been examined in animal and clinical settings. Unlike embryonic and induced pluripotent stem cells, ASCs do not pose a threat to form teratomas, nor do they have immune system concerns, making them ideal for therapeutic use in humans. In this review, we will investigate different characteristics and sources of adult stem cells and progenitor cells, as well as determine their efficacy in cell transplantation in experimental and clinical trials...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28220117/the-tumorigenicity-of-multipotent-adult-germline-stem-cells-transplanted-into-the-heart-is-affected-by-natural-killer-cells-and-by-cyclosporine-a-independent-of-its-immunosuppressive-effects
#2
Daniela Hübscher, Diana Kaiser, Leslie Elsner, Sebastian Monecke, Ralf Dressel, Kaomei Guan
Transplantation of stem cells represents an upcoming therapy for many degenerative diseases. For clinical use, transplantation of pluripotent stem cell-derived cells should lead to integration of functional grafts without immune rejection or teratoma formation. Our previous studies showed that the risk of teratoma formation is highly influenced by the immune system of the recipients. In this study, we have observed a higher teratoma formation rate when undifferentiated so-called multipotent adult germline stem cells (maGSCs) were transplanted into the heart of T, B, and natural killer (NK) cell-deficient RAG2(-/-)γc(-/-) mice than in RAG2(-/-) mice, which still have NK cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28217238/fetus-in-fetu-case-report-and-brief-review-of-literature-on-embryologic-origin-clinical-presentation-imaging-and-differential-diagnosis
#3
Suhas Aithal Sitharama, Bibekanand Jindal, Mrudula Kumari Vuriti, Bikash Kumar Naredi, Sriram Krishnamurthy, Deepak Barathi Subramania
BACKGROUND: Fetus in fetu (FIF) is a rare entity in which a malformed diamniotic monochorionic parasitic fetal twin develops inside a normal co-twin's body, most commonly in the abdominal cavity. FIF is differentiated from the teratoma by the presence of vertebral column often with an appropriate arrangement of other organs or limbs around it. CASE REPORT: A two-and-a-half-year-old girl presented with a painless abdominal swelling in the right hypochondrium. On imaging, a heterogenous soft tissue mass with internal calcific densities was noted in the retroperitoneum...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28217075/giant-sacrococcygeal-teratoma-management-concerns-with-reporting-of-a-rare-occurrence-of-venous-air-embolism
#4
Anudeep Jafra, Deepak Dwivedi, Divya Jain, Indu Bala
No abstract text is available yet for this article.
January 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28214217/malignant-tumors-associated-with-ovarian-mature-teratoma-a-single-institution-experience
#5
Levent Trabzonlu, Guray Durmaz, Cigdem Vural, Bahar Muezzinoglu, Aydin Corakci
OBJECTIVE: The aims of this study are to present demographical features of cases diagnosed with malignant tumor associated with ovarian mature teratoma and to analyze histopathological features and clinical follow up of these tumors. STUDY DESIGN: Single-institution retrospective charts were reviewed to identify all cases of ovarian mature teratoma diagnosed from 1998 to 2015. Clinicopathological parameters that were analyzed include age, tumor size, tumor stage, histological type, laterality, IOC diagnosis and whether or not patient has received adjuvant chemotherapy...
January 22, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28208952/rare-site-of-parasitic-dermoid-cyst-at-uterovesical-fold-of-peritoneum-with-absent-one-sided-adnexa
#6
Sunita Dubey, Alka Sehgal, Puneeti Ballega, Rps Punia
Teratomas are the most common type of germ cell tumour. It can be congenital or acquired and are usually found in gonads (testes and ovaries). Parasitic dermoid cysts are rare and their actual incidence is unknown. We are reporting a case of 25-year-old gravida two, para one and one living child, who underwent emergency cesarean section in view of symptomatic placenta previa. A parasitic dermoid cyst was found incidently in front of uterus which was attached to uterovasical fold of bladder. This cyst did not show any connection to uterus or adnexa...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208935/mature-teratoma-at-left-lumbar-region-in-an-infant-a-case-report
#7
Rajendra Kumar Ghritlaharey
Common location of teratomas in children are sacrococcygeal, gonadal, mediastinal and retroperitoneal, but teratomas may also occur at very unusual locations. A six-month-old boy presented with a large swelling at his left lumbar region. He presented with gradually increasing lump at his back, involving more on left lumbar region and midline since birth. Clinical examination revealed a solitary, non-tender, soft to firm, irregular mass, occupying more on his left lumbar and midline region and also crossing the midline...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208869/mature-cystic-teratoma-with-co-existent-mucinous-cystadenocarcinoma-in-the-same-ovary-a-diagnostic-dilemma
#8
Sanjeet Roy, Sramana Mukhopadhayay, Mayank Gupta, Anuradha Chandramohan
Mature cystic teratoma co-existing with a mucinous cystadenocarcinoma is an infrequently encountered entity with only a handful of cases reported till date. The possibilities in such a case are either a malignant transformation of a benign teratoma into adenocarcinoma or a collision tumor between a mature cystic teratoma and a mucinous tumour of either a primary ovarian surface epithelial-stromal origin or a secondary from a primary gastrointestinal tract tumour. The importance of distinguishing between the two entities has significant bearing on subsequent therapeutic management...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207469/sequence-of-surgical-reconstruction-in-a-child-with-cleft-lip-and-palate-associated-with-congenital-facial-teratomas
#9
Oswaldo J Gómez Díaz, Mario D Cruz Sánchez
We describe a case of left homolateral complete cleft lip/palate associated with a congenital left maxillary teratoma and left orbital teratoma. The patient required step-by-step reconstruction that first included resection of the 2 teratomas in consideration of cleft lip repair, cleft palate repair, and correction of the left periorbital anomalies, which were performed later. After performing all the necessary procedures, complete resection of the tumors and correction of the anomalies associated with the lip, palate, and left orbit were achieved...
February 15, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28203171/a-squamous-cell-carcinoma-and-a-malignant-fibrous-histiocytoma-developing-in-a-patient-with-a-mature-cystic-teratoma
#10
Ali Emre Tahaoglu, Serhat Ege, Mehmet Sait Bakir, Gülbin Saruhan, Serif Aksin, Talip Gul
We present a very rare case of malignant transformation of a benign mature cystic teratoma. The pathology report revealed malignant transformation of both the epithelial and sarcomatous elements of a benign dermoid cyst. To the best of our knowledge, this appears to be the third case of a malignant fibrous histiocytoma and a squamous cell carcinoma developing from a mature cystic teratoma. Malignant transformation of a dermoid cyst is usually diagnosed postmenopausally, but our patient was premenopausal. The etiology and prognosis of malignant transformation of this benign condition remain unknown...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28195108/mucoepidermoid-carcinoma-in-a-mature-cystic-teratoma-a-rare-case-report-with-review-of-literature
#11
Yasmin Altaf Momin, Medha Pradip Kulkarni, Amitkumar Bapuso Pandav, Kalpana Ranjitsingh Sulhyan
Mature cystic teratoma, also known as dermoid cyst, is the most common germ cell tumor of the ovary with a relative incidence of 20%. Rarely, dermoid cysts undergo malignant transformation (0.94%-2%). We report a case of mucoepidermoid carcinoma within a mature cystic teratoma in a 35-year-old female.
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28191782/preventing-pluripotent-cell-teratoma-in-regenerative-medicine-applied-to-hematology-disorders
#12
Aurelie Bedel, François Beliveau, Isabelle Lamrissi-Garcia, Benoit Rousseau, Isabelle Moranvillier, Benoit Rucheton, Veronique Guyonnet-Dupérat, Bruno Cardinaud, Hubert de Verneuil, François Moreau-Gaudry, Sandrine Dabernat
Iatrogenic tumorigenesis is a major limitation for the use of human induced pluripotent stem cells (hiPSCs) in hematology. The teratoma risk comes from the persistence of hiPSCs in differentiated cell populations. Our goal was to evaluate the best system to purge residual hiPSCs before graft without compromising hematopoietic repopulation capability. Teratoma risk after systemic injection of hiPSCs expressing the reporter gene luciferase was assessed for the first time. Teratoma formation in immune-deficient mice was tracked by in vivo bioimaging...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28190856/virilism-and-ectopic-expression-of-hsd17b5-in-mature-cystic-teratoma
#13
Yohei Kawaguchi, Hiroko Mizuno, Mai Horikawa, Mayuko Kano, Kengo Yamada, Fumiko Yamakawa, Takashi Maekawa, Yuto Yamazaki, Keely M McNamara, Hironobu Sasano, Masayuki Hayashi
Mature cystic teratoma (MCT) is rarely involved in the overproduction of steroid hormones in contrast to sex cord stromal tumors. A 31-year-old woman visited our hospital with hirsutism, hoarseness, and hair loss from the scalp. Serum testosterone and free-testosterone levels were 7.3 ng/ml and 2.3 pg/ml, respectively, which were markedly in excess of the age adjusted female standard levels. Basal blood levels of steroid hormones and serum levels of 17-hydroxyprogesterone at 1 h after intravenous injection of adrenocorticotropic hormone demonstrated that 21-hydroxylase deficiency was not the underlying cause of her virilization...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28185769/intact-wound-repair-activity-of-human-mesenchymal-stem-cells-after-ym155-mediated-selective-ablation-of-undifferentiated-human-embryonic-stem-cells
#14
Keun-Tae Kim, Ho-Chang Jeong, C-Yoon Kim, Eun-Young Kim, Si-Hyun Heo, Seung-Ju Cho, Ki-Sung Hong, Hyuk-Jin Cha
BACKGROUND: Risk of teratoma formation during human pluripotent stem cell (hPSC)-based cell therapy is one of the technical hurdles that must be resolved before their wider clinical application. To this end, selective ablation of undifferentiated hPSCs has been achieved using small molecules whose application should be safe for differentiated cells derived from the hPSCs. OBJECTIVE: However, the functional safety of such small molecules in the cells differentiated from hPSCs has not yet been extensively validated...
January 31, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28185259/ips-cell-derived-gamete-associated-proteins-gaps-incite-rejection-of-ipscs-in-syngeneic-mice
#15
Eun-Mi Kim, Gohar Manzar, Nicholas Zavazava
The safety of iPS cells (iPSCs) in autologous recipients has been questioned after iPSCs, but not ES cells (ESCs), were reported to be rejected in syngeneic mice. This important topic has remained controversial because there has not been a mechanistic explanation for this phenomenon. Here, we hypothesized that iPSCs, but not ESCs, readily differentiate into gamete-forming cells that express meiotic antigens normally found in immune-privileged gonads. Because peripheral blood T cells are not tolerized to these antigens in the thymus, gamete-associated-proteins (GAPs) sensitize T cells leading to rejection...
February 10, 2017: Immunology
https://www.readbyqxmd.com/read/28179190/species-specific-developmental-timing-is-maintained-by-pluripotent-stem-cells-ex-utero
#16
Christopher Barry, Matthew T Schmitz, Peng Jiang, Michael P Schwartz, Bret M Duffin, Scott Swanson, Rhonda Bacher, Jennifer M Bolin, Angela L Elwell, Brian E McIntosh, Ron Stewart, James A Thomson
How species-specific developmental timing is controlled is largely unknown. By following human embryonic stem (ES) cell and mouse epiblast stem (EpiS) cell differentiation through detailed RNA-sequencing time courses, here we show that pluripotent stem cells closely retain in vivo species-specific developmental timing in vitro. In identical neural differentiation conditions in vitro, gene expression profiles are accelerated in mouse EpiS cells compared to human ES cells with relative rates of differentiation closely reflecting the rates of progression through the Carnegie stages in utero...
February 6, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28178716/invasive-haemophilus-influenzae-infection-in-patients-with-cancer
#17
Vivek Singh, Sowmya Nanjappa, Smitha Pabbathi, John N Greene
A major cause of morbidity and mortality in patients with cancer is infection. Since the introduction of the Haemophilus influenzae type b (Hib) vaccine in the United States in the 1990s, invasive H influenzae infection has become less common. We report on 5 patients with cancer and invasive H influenzae infection. A literature review was also performed of the dominant Haemophilus subtype and the clinical features associated with the infection and concomitant cancer. Of the 17 cases found in the literature, had hematological malignancies and 1 case each had thymoma, schwannoma, teratoma, and pancreatic, Merkel cell, pharyngeal, laryngeal, and rectal carcinomas...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28174646/agenesis-of-the-dorsal-pancreas-associated-with-mucinous-adenocarcinoma-and-cystic-teratoma-a-case-report-and-literature-review
#18
Elias Saikaly, Antoine El Asmar, Fahim Abi Fadel, Mona Aoun, Ziad El Rassi
Dorsal agenesis of the pancreas is a rare congenital anomaly. Fifty-eight cases were reported from 1913 till 2015, nine of which were associated with tumors. We present the 10th case, the first to be associated with pancreatic mucinous adenocarcinoma and cystic teratoma, successfully managed by Whipple procedure and total pancreatectomy.
February 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28170177/pluripotent-nontumorigenic-adipose-tissue-derived-muse-cells-have-immunomodulatory-capacity-mediated-by-transforming-growth-factor-%C3%AE-1
#19
María L Gimeno, Florencia Fuertes, Andres E Barcala Tabarrozzi, Alejandra I Attorressi, Rodolfo Cucchiani, Luis Corrales, Talita C Oliveira, Mari C Sogayar, Leticia Labriola, Ricardo A Dewey, Marcelo J Perone
Adult mesenchymal stromal cell-based interventions have shown promising results in a broad range of diseases. However, their use has faced limited effectiveness owing to the low survival rates and susceptibility to environmental stress on transplantation. We describe the cellular and molecular characteristics of multilineage-differentiating stress-enduring (Muse) cells derived from adipose tissue (AT), a subpopulation of pluripotent stem cells isolated from human lipoaspirates. Muse-AT cells were efficiently obtained using a simple, fast, and affordable procedure, avoiding cell sorting and genetic manipulation methods...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28166073/ovarian-tumors-pattern-of-histomorphological-types-a-10-years-study-in-a-tertiary-referral-center-and-review-of-literature
#20
A Ghosh, D Ghartimagar, S Thapa, B Sathian, R Narasimhan, O P Talwar
Background Ovarian cancer accounts for 6% of all cancers in females. Among cancers of female genital tract, the incidence of ovarian cancers ranks below only carcinoma of the cervix and the endometrium. Objective To find the frequency of different types of histomorphological types and their association with age, side and size distribution. Method This study is a hospital based retrospective study carried out in the Department of Pathology, Manipal Teaching Hospital over a time period from Jan. 2006 to Sep. 2015...
April 2016: Kathmandu University Medical Journal (KUMJ)
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