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stem cell urinary incontinence carr

L K Carr, D Steele, S Steele, D Wagner, R Pruchnic, R Jankowski, J Erickson, J Huard, M B Chancellor
We hereby report a 1-year follow-up on eight women in the first North America trial in which stress urinary incontinence (SUI) was treated with muscle-derived stem cell injections. Mean and median follow-up in this group was 16.5 and 17 months (range 3-24 months). Improvement in SUI was seen in five of eight women, with one achieving total continence. Onset of improvement was between 3 and 8 months after injection. Cure or improvement continued at a median of 10 months. No serious adverse events were reported...
June 2008: International Urogynecology Journal and Pelvic Floor Dysfunction
Akira Furuta, Lesley K Carr, Naoki Yoshimura, Michael B Chancellor
The middle urethra and external urethral sphincter are the focus in management of stress urinary incontinence, and recent cellular-therapy research suggests a new paradigm in treatment. Cell-based therapies are most often described as using autologous multipotent stem cells procured from bone marrow in procedures that may be painful, require anesthesia, and yield low numbers of mesenchymal stem cells upon processing. In contrast, muscleand adipose-derived stem cells can be obtained easily in large quantities under local anesthesia...
2007: Reviews in Urology
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