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https://www.readbyqxmd.com/read/27931050/improved-detection-of-right-colon-adenomas-with-additional-retroflexion-following-two-forward-view-examinations-a-prospective-study
#1
Hyun Seok Lee, Seong Woo Jeon, Hye Yoon Park, Seong Jae Yeo
Background and study aims Colonoscopy in the right colon is less effective than in the left colon in screening for colorectal cancer. The aim of this study was to prospectively evaluate the diagnostic value of retroflexion in the right colon. Patients and methods A total of 1020 patients undergoing screening or surveillance colonoscopy were enrolled. After the first cecal intubation, the scope was withdrawn from the cecum to the hepatic flexure in the standard forward view and all identified polyps were resected...
December 8, 2016: Endoscopy
https://www.readbyqxmd.com/read/27928460/asymptomatic-anisakiasis-of-the-colon-incidentally-diagnosed-and-treated-during-colonoscopy-by-retroflexion-in-the-ascending-colon
#2
Mamiko Tsukui, Naoki Morimoto, Hidekazu Kurata, Fumiko Sunada
A 74-year-old man with diabetes underwent colonoscopy as routine screening for colon cancer. An Anisakis larva was found incidentally during colonoscopy using the retroflexion technique in the ascending colon, and was removed using a forceps. Asymptomatic colonic anisakiasis is very rare, and few reports have described diagnosis and treatment of anisakiasis during colonoscopy by the retroflexion technique in the ascending colon. We have reported this rare case along with a literature review.
2016: Journal of Rural Medicine: JRM
https://www.readbyqxmd.com/read/27927666/epigenetic-biomarkers-in-progression-from-non-dysplastic-barrett-s-oesophagus-to-oesophageal-adenocarcinoma-a-systematic-review-protocol
#3
T Nieto, C L Tomlinson, J Dretzke, S Bayliss, M Dilworth, A D Beggs, O Tucker
INTRODUCTION: Barrett's oesophagus (BO), a metaplastic condition affecting the lower oesophagus due to long-standing gastro-oesophageal reflux and chronic inflammation, is a precursor lesion for oesophageal adenocarcinoma (OADC). There is no clinical test to predict which patients with BO will progress to OADC. The British Society of Gastroenterology recommends endoscopic surveillance of patients with BO. Epigenetic changes have been well characterised in the neoplastic progression of ulcerative colitis to colonic carcinoma, another gastrointestinal cancer associated with chronic inflammation...
December 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27926650/group-b-streptococci-screening-before-repeat-cesarean-delivery-a-cost-effectiveness-analysis
#4
Catherine M Albright, Caitlin MacGregor, Desmond Sutton, Meena Theva, Brenna L Hughes, Erika F Werner
OBJECTIVE: To estimate the cost-effectiveness of universal group B streptococci (GBS) screening in women with a singleton pregnancy planning a repeat cesarean delivery. METHODS: We conducted a decision analysis from a health care perspective to compare the cost-effectiveness of GBS screening for women planning a repeat cesarean delivery. With universal screening, all GBS-positive women who labored before a scheduled cesarean delivery received antibiotic prophylaxis...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926565/oncologic-outcomes-following-laparoscopic-versus-open-resection-of-pt4-colon-cancer-a-systematic-review-and-meta-analysis
#5
Adina E Feinberg, Tyler R Chesney, Sergio A Acuna, Tarik Sammour, Fayez A Quereshy
BACKGROUND: Locally advanced colon cancer is considered a relative contraindication for laparoscopic resection, and clinical trials addressing the oncologic safety are lacking. OBJECTIVE: The aim of this study was to synthesize the oncologic outcomes associated with laparoscopic versus conventional open surgery for locally advanced colon cancers. DATA SOURCES: We systematically searched Medline, Embase, Central, and ClinicalTrials.gov. STUDY SELECTION: Two reviewers independently screened the literature for controlled trials or observational studies comparing curative-intent laparoscopic and open surgery for colon cancer...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27923757/the-potentially-fatal-ogilvie-s-syndrome-in-lateral-transpsoas-access-surgery-a-multi-institutional-experience-with-2930-patients
#6
Jacob Januszewski, Sean K Keem, William Smith, Joshua M Beckman, Adam S Kanter, Rod J Oskuian, William Taylor, Juan S Uribe
BACKGROUND: Ogilvie's syndrome (OS) is a relatively uncommon pathology characterized by significant colonic dilation in the absence of mechanical obstruction. If unrecognized and untreated, cecal perforation resulting in mortality rate of 25-71% may occur. It is a potentially underdiagnosed condition in the lateral transpsoas appraoch population due to its uncommon nature and imitation of other well-known pathologies. METHODS: A total of 2930 patients from 6 separate institutions were retrospectively reviewed since 2007 and screened for OS...
December 3, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27923069/characterization-in-helicobacter-pylori-of-a-nickel-transporter-essential-for-colonization-that-was-acquired-during-evolution-by-gastric-helicobacter-species
#7
Frédéric Fischer, Marie Robbe-Saule, Evelyne Turlin, Francesco Mancuso, Valérie Michel, Pierre Richaud, Frédéric J Veyrier, Hilde De Reuse, Daniel Vinella
Metal acquisition is crucial for all cells and for the virulence of many bacterial pathogens. In particular, nickel is a virulence determinant for the human gastric pathogen Helicobacter pylori as it is the cofactor of two enzymes essential for in vivo colonization, urease and a [NiFe] hydrogenase. To import nickel despite its scarcity in the human body, H. pylori requires efficient uptake mechanisms that are only partially defined. Indeed, alternative ways of nickel entry were predicted to exist in addition to the well-described NixA permease...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27922695/effects-of-five-candidate-laxatives-derived-from-liriope-platyphylla-on-the-5-ht-receptor-signaling-pathway-in-three-cell-types-present-in-the-transverse-colon
#8
Ji Eun Kim, Eun Kyoung Koh, Sung Hwa Song, Ji Eun Sung, Hyun Ah Lee, Hong Gu Lee, Young Whan Choi, Dae Youn Hwang
The laxative effects of aqueous extract of Liriope platyphylla (AEtLP) on loperamide (Lop)‑induced constipation have been reported; however, the key compounds and the mechanism underlying these effects remain unclear. Therefore, the laxative effects of five candidates derived from L. platyphylla: Diosgenin (DG), 5-hydroxymethylfurfural (5-HMF), adenosine (AD), hydroxypropyl cellulose (HPC) and uridine (UD) were investigated by examining the alteration of G protein α (Gα) expression, protein kinase C (PKC) phosphorylation and inositol triphosphate (IP3) concentration levels in the 5-hydroxytryptamine (5‑HT; serotonin) receptor signaling pathway...
December 5, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27920469/role-of-ultrasound-in-colorectal-diseases
#9
REVIEW
Renáta Bor, Anna Fábián, Zoltán Szepes
Ultrasound is an undervalued non-invasive examination in the diagnosis of colonic diseases. It has been replaced by the considerably more expensive magnetic resonance imaging and computed tomography, despite the fact that, as first examination, it can usefully supplement the diagnostic process. Transabdominal ultrasound can provide quick information about bowel status and help in the choice of adequate further examinations and treatment. Ultrasonography, as a screening imaging modality in asymptomatic patients can identify several colonic diseases such as diverticulosis, inflammatory bowel disease or cancer...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27911391/a-murine-model-of-group-b-streptococcus-vaginal-colonization
#10
Kathryn A Patras, Kelly S Doran
Streptococcus agalactiae (group B Streptococcus, GBS), is a Gram-positive, asymptomatic colonizer of the human gastrointestinal tract and vaginal tract of 10 - 30% of adults. In immune-compromised individuals, including neonates, pregnant women, and the elderly, GBS may switch to an invasive pathogen causing sepsis, arthritis, pneumonia, and meningitis. Because GBS is a leading bacterial pathogen of neonates, current prophylaxis is comprised of late gestation screening for GBS vaginal colonization and subsequent peripartum antibiotic treatment of GBS-positive mothers...
November 16, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27910062/plasma-and-saliva-mir-21-expression-in-colorectal-cancer-patients
#11
A A Sazanov, E V Kiselyova, A A Zakharenko, M N Romanov, M I Zaraysky
MicroRNA-21 (miR-21) expression was quantified by real-time qRT-PCR in peripheral blood and saliva samples obtained from patients diagnosed with colorectal cancer (CRC) of varying degrees of malignancy and healthy volunteers. All patients had adenocarcinoma located in the distal colon at different stages. Significant differences were detected between the control group and the total experimental group of CRC patients (plasma, P = 0.0001; saliva, P = 5e-12). MiR-21 expression was also significantly different in certain subgroups of patients with CRC disease stages II-IV as compared to the control group...
December 2, 2016: Journal of Applied Genetics
https://www.readbyqxmd.com/read/27909459/a-case-of-ileus-in-a-patient-with-schizophrenia-under-paliperidone-palmitate-treatment
#12
Serdar Süleyman Can, Esra Kabadayı
Constipation is a side effect of antipsychotic drugs that have high affinity for muscarinic cholinergic receptors. In addition, ileus is an important side effect of antipsychotic treatment, with potentially morbid and mortal consequences if early detection fails. In this report, a colonic ileus case is described in a patient with schizophrenia under the treatment of paliperidone palmitate. Consequently, complete physical examination and close screening of side effects are recommended when antipsychotics are prescribed...
November 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27907032/genetic-structure-in-the-northern-range-margins-of-common-ash-fraxinus-excelsior-l
#13
Mari Mette Tollefsrud, Tor Myking, Jørn Henrik Sønstebø, Vaidotas Lygis, Ari Mikko Hietala, Myriam Heuertz
During post glacial colonization, loss of genetic diversity due to leading edge effects may be attenuated in forest trees because of their prolonged juvenile phase, allowing many migrants to reach the colonizing front before populations become reproductive. The northern range margins of temperate tree taxa in Europe are particularly suitable to study the genetic processes that follow colonization because they have been little affected by northern refugia. Here we examined how post glacial range dynamics have shaped the genetic structure of common ash (Fraxinus excelsior L...
2016: PloS One
https://www.readbyqxmd.com/read/27904404/phenolic-composition-antioxidant-capacity-and-in-vitro-cytotoxicity-assessment-of-fruit-wines
#14
Ana Ljevar, Natka Ćurko, Marina Tomašević, Kristina Radošević, Višnja Gaurina Srček, Karin Kovačević Ganić
Fruit wines contain a wide range of phenolic compounds with biological effects, but their composition and potential benefits to human health have been studied to the much lesser extent compared to grape wines. The aim of this research is to study the phenolic profile of different types of fruit wines and to evaluate their antioxidant and biological potential. Commercially available fruit wines from blackberry, cherry, raspberry, blackcurrant, strawberry and apple produced in Croatia were analyzed. To the best of our knowledge, this study represents the first comprehensive screening of Croatian fruit wines...
June 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27900697/screening-for-n-ahsl-based-signaling-interfering-enzymes
#15
Stéphane Uroz, Phil M Oger
Quorum sensing (QS)-based signaling is a widespread pathway used by bacteria for the regulation of functions involved in their relation to the environment or their host. QS relies upon the production, accumulation and perception of small diffusable molecules by the bacterial population, hence linking high gene expression with high cell population densities. Among the different QS signal molecules, an important class of signal molecules is the N-acyl homoserine lactone (N-AHSL). In pathogens such as Erwinia or Pseudomonas, N-AHSL based QS is crucial to overcome the host defenses and ensure a successful infection...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27900286/selective-and-efficient-elimination-of-vibrio-cholerae-with-a-chemical-modulator-that-targets-glucose-metabolism
#16
Young Taek Oh, Hwa Young Kim, Eun Jin Kim, Junhyeok Go, Wontae Hwang, Hyoung Rae Kim, Dong Wook Kim, Sang Sun Yoon
Vibrio cholerae, a Gram-negative bacterium, is the causative agent of pandemic cholera. Previous studies have shown that the survival of the seventh pandemic El Tor biotype V. cholerae strain N16961 requires production of acetoin in a glucose-rich environment. The production of acetoin, a neutral fermentation end-product, allows V. cholerae to metabolize glucose without a pH drop, which is mediated by the production of organic acid. This finding suggests that inhibition of acetoin fermentation can result in V...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27898265/prospects-for-biological-soil-borne-disease-control-application-of-indigenous-versus-synthetic-microbiomes
#17
Mark Mazzola, Shiri Freilich
Biological disease control of soil-borne plant diseases has traditionally employed the biopesticide approach whereby single strains or strain mixtures are introduced into production systems through inundative/inoculative release. The approach has significant barriers that have long been recognized, including a generally limited spectrum of target pathogens for any given biocontrol agent andinadequate colonization of the host rhizosphere, which can plague progress in the utilization of this resource in commercial field-based crop production systems...
November 29, 2016: Phytopathology
https://www.readbyqxmd.com/read/27895773/dysregulation-of-long-non-coding-rna-profiles-in-human-colorectal-cancer-and-its-association-with-overall-survival
#18
Lei Yang, Lingling Xu, Qian Wang, Min Wang, Guangyu An
Long non-coding RNAs (lncRNAs) emerged as key regulators of diverse roles during colorectal cancer (CRC) carcinogenesis, but their specific function still remains to be explored. The present study aimed to re-annotate the Affymetrix Human Exon 1.0 ST Array for defining differential lncRNAs in CRC. Their prognostic relevance was also developed for screening key regulators in CRC. The CRC datasets E-GEOD-31737, E-MATB-829, Affymetrix colon cancer dataset and E-GEOD-24550 were re-purposed for searching differential lncRNAs and exploring their association with overall survival (OS)...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895127/the-pathogenic-potential-of-proteus-mirabilis-is-enhanced-by-other-uropathogens-during-polymicrobial-urinary-tract-infection
#19
Chelsie E Armbruster, Sara N Smith, Alexandra O Johnson, Valerie DeOrnellas, Kathryn A Eaton, Alejandra Yep, Lona Mody, Weisheng Wu, Harry L T Mobley
Urinary catheter use is prevalent in health care settings, and polymicrobial colonization by urease-positive organisms, such as Proteus mirabilis and Providencia stuartii, commonly occurs with long-term catheterization. We previously demonstrated that coinfection with P. mirabilis and P. stuartii increased overall urease activity in vitro and disease severity in a model of urinary tract infection (UTI). In this study, we expanded these findings to a murine model of catheter-associated UTI (CAUTI), delineated the contribution of enhanced urease activity to coinfection pathogenesis, and screened for enhanced urease activity with other common CAUTI pathogens...
November 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27890334/control-of-carbapenemase-producing-enterobacteriaceae-outbreaks-in-acute-settings-an-evidence-review
#20
REVIEW
C E French, C Coope, L Conway, J P T Higgins, J McCulloch, G Okoli, B C Patel, I Oliver
BACKGROUND: In recent years, infections with carbapenemase-producing Enterobacteriaceae (CPE) have been increasing globally and present a major public health challenge. AIM: To review the international literature: (i) to describe CPE outbreaks in acute hospital settings globally; and (ii) to identify the control measures used during these outbreaks and report on their effectiveness. METHODS: A systematic search of MEDLINE and EMBASE databases, abstract lists for key conferences and reference lists of key reviews was undertaken, and information on unpublished outbreaks was sought for 2000-2015...
October 14, 2016: Journal of Hospital Infection
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