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Colon cancer epidemiology

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https://www.readbyqxmd.com/read/29791319/malignancy-in-a-retrospective-cohort-of-17-patients-with-dermatomyositis-or-polymyositis-in-southern-tunisia
#1
Khadija Sellami, Madiha Mseddi, Mouna Snoussi, Hela Gharbi, Faten Frikha, Rayda Ben Salah, Moez Jallouli, Sameh Marzouk, Abderrahmen Masmoudi, Zouhir Bahloul, Hamida Turki
INTRODUCTION: The prognosis of dermatomyositis (DM)/polymyositis (PM) in adults is partly related to their association with neoplasia. The aim of our study was to report the epidemiologic, clinical, paraclinical, therapeutic and evolutionary aspects of DM associated with malignancy in patients from Sfax, south eastern of Tunisia. METHODS: A retrospective cohort study of patients with DM or PM admitted in Dermatology and Internal Medicine Departments of Hedi Chaker University Hospital of Sfax between 1996 and 2015...
May 21, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29780357/altered-circadian-rhythms-and-breast-cancer-from-the-human-to-the-molecular-level
#2
REVIEW
Hui-Hsien Lin, Michelle E Farkas
Circadian clocks are fundamental, time-tracking systems that allow organisms to adapt to the appropriate time of day and drive many physiological and cellular processes. Altered circadian rhythms can result from night-shift work, chronic jet lag, exposure to bright lights at night, or other conditioning, and have been shown to lead to increased likelihood of cancer, metabolic and cardiovascular diseases, and immune dysregulation. In cases of cancer, worse patient prognoses and drug resistance during treatment have also been observed...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29770845/real-world-study-of-a-novel-prognostic-scoring-system-for-a-more-precise-prognostication-and-better-clinical-treatment-guidance-in-stages-ii-and-iii-colon-cancer
#3
Qi Liu, Yanlei Ma, Dakui Luo, Sanjun Cai, Qingguo Li, Xinxiang Li
PURPOSE: This study aimed to improve the American Joint Committee on Cancer (AJCC) Tumor Node Metastases (TNM) staging system and demonstrate the improvement in prognostic accuracy and clinical management guidance in colon cancer using the novel prognostic score (P score). METHODS: Eligible patients were identified using the Surveillance, Epidemiology, and End Results database. A P score (based on age, tumor size, and tumor grade) was assigned to each patient. The Cox proportional hazards regression analyses were performed to identify independent factors associated with prognosis...
May 16, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29761424/dietary-intake-of-total-polyphenol-and-polyphenol-classes-and-the-risk-of-colorectal-cancer-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-cohort
#4
Raul Zamora-Ros, Valerie Cayssials, Mazda Jenab, Joseph A Rothwell, Veronika Fedirko, Krasimira Aleksandrova, Anne Tjønneland, Cecilie Kyrø, Kim Overvad, Marie-Christine Boutron-Ruault, Franck Carbonnel, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Elissavet Valanou, Effie Vasilopoulou, Giovanna Masala, Valeria Pala, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Elisabete Weiderpass, Marko Lukic, Torkjel M Sandanger, Cristina Lasheras, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, Carmen Navarro, Eva Ardanaz, Emily Sonestedt, Bodil Ohlsson, Lena Maria Nilsson, Martin Rutegård, Bas Bueno-de-Mesquita, Petra H Peeters, Kay-Thee Khaw, Nicholas J Wareham, Kathryn Bradbury, Heinz Freisling, Isabelle Romieu, Amanda J Cross, Paolo Vineis, Augustin Scalbert
Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries...
May 15, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29757939/heterogeneity-in-the-relationship-between-disinfection-by-products-in-drinking-water-and-cancer-a-systematic-review
#5
Tarik Benmarhnia, Ianis Delpla, Lara Schwarz, Manuel J Rodriguez, Patrick Levallois
The epidemiological evidence demonstrating the effect of disinfection by-products (DBPs) from drinking water on colon and rectal cancers is well documented. However, no systematic assessment has been conducted to assess the potential effect measure modification (EMM) in the relationship between DBPs and cancer. The objective of this paper is to conduct a systematic literature review to determine the extent to which EMM has been assessed in the relationship between DBPs in drinking water in past epidemiological studies...
May 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29755764/tumor-location-impact-in-stage-ii-and-iii-colon-cancer-epidemiological-and-outcome-evaluation
#6
Nesrine Mejri, Manel Dridi, Houda El Benna, Soumaya Labidi, Nouha Daoud, Hamouda Boussen
Background: We aimed to describe clinico-pathological characteristics and differences between right-sided (RCC) and left-sided colon cancer (LCC) in Tunisian population. We also analyzed outcome to determine whether location is of prognostic significance. Methods: Clinico-pathological characteristics and Kaplan Meier survival were compared between two groups of LCC [150] and RCC [53] patients with stage II and III adenocarcinoma treated with curative intent between 2003-2014...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29751794/prognostic-value-of-total-number-of-lymph-nodes-retrieved-differs-between-left-sided-colon-cancer-and-right-sided-colon-cancer-in-stage-iii-patients-with-colon-cancer
#7
Lin Yang, Zhenchong Xiong, Qiankun Xie, Wenzhuo He, Shousheng Liu, Pengfei Kong, Chang Jiang, Guifang Guo, Liangping Xia
BACKGROUND: The consensus is that a minimum of 12 lymph nodes should be analyzed at colectomy for colon cancer. However, right colon cancer and left colon cancer have different characteristics, and this threshold value for total number of lymph nodes retrieved may not be universally applicable. METHODS: The data of 63,243 patients with colon cancer treated between 2004 and 2012 were retrieved from the National Cancer Institute's Surveillance, Epidemiology, and End Results database...
May 11, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29731694/the-role-of-some-adam-proteins-and-activation-of-the-insulin-growth-factor-related-pathway-in-colorectal-cancer
#8
REVIEW
Katarzyna Walkiewicz, Ewa Nowakowska-Zajdel, Paweł Kozieł, Małgorzata Muc-Wierzgoń
Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. In Poland, colorectal cancer ranks second in tumor incidence regardless of sex; moreover, there has been a steady increase in the incidence of CRC. CRC results from complex interactions between inherited susceptibility, clinical conditions and environmental/lifestyle-related risk factors such as physical inactivity, smoking, alcohol consumption, high-fat/low-fiber diet, and obesity/overweight. The activation of pathways associated with insulin resistance and insulin-like growth factors (IGF) appears to be the epidemiological link between the metabolic syndrome and the development of CRC, which is of particular importance...
2018: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29726125/long-term-oncological-outcomes-of-local-excision-versus-radical-resection-for-early-colorectal-cancer-in-young-patients-without-preoperative-chemoradiotherapy-a-population-based-propensity-matching-study
#9
Bin Cao, Li Min, Shengtao Zhu, Haiyun Shi, Shutian Zhang
The incidence and mortality of colorectal carcinoma are rising in young adults. This population-based propensity matching study aimed to compare long-term oncological outcomes of local excision with radical resection for early localized colorectal cancer (CRC) in young patients without preoperative chemoradiotherapy. Patients under 45 years old with T1 colon or rectal adenocarcinoma who underwent local excision or radical resection were included from the Surveillance, Epidemiology, and End Results (SEER) database between 1998 and 2014...
May 3, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29721198/global-burden-of-neuroendocrine-tumors-and-changing-incidence-in-kentucky
#10
Aman Chauhan, Qian Yu, Neha Ray, Zainab Farooqui, Bin Huang, Eric B Durbin, Thomas Tucker, Mark Evers, Susanne Arnold, Lowell B Anthony
Background: Neuroendocrine tumors (NETs) have a low incidence but relatively high prevalence. Over the last three decades, the incidence of NETs has risen 6-fold in the United States. We conducted an observational study to compare the incidence of NETs reported to the Kentucky Cancer Registry (KCR) versus that reported to Surveillance, Epidemiology, and End Results Program (SEER). We also provide a systematic review of the state of neuroendocrine tumors worldwide, and compare the available global and local published data...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29720903/colorectal-cancer-in-inflammatory-bowel-disease
#11
REVIEW
Ryan W Stidham, Peter D R Higgins
Patients with inflammatory bowel disease (IBD) are at significantly increased risk of colorectal cancer (CRC), principally resulting from the pro-neoplastic effects of chronic intestinal inflammation. Epidemiologic studies continue to highlight the increased risk of CRC in IBD. However, the incidence has declined over the past 30 years, attributed to both successful CRC-surveillance programs and improved control of mucosal inflammation. Risk factors that further increase the risk of IBD-related CRC include disease duration, extent and severity, the presence of inflammatory pseudopolyps, coexistent primary sclerosing cholangitis, and a family history of CRC...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29713943/the-association-of-diet-gut-microbiota-and-colorectal-cancer-what-we-eat-may-imply-what-we-get
#12
REVIEW
Jia Yang, Jun Yu
Despite the success of colonoscopy screening and recent advances in cancer treatment, colorectal cancer (CRC) still remains one of the most commonly diagnosed and deadly cancers, with a significantly increased incidence in developing countries where people are adapting to Western lifestyle. Diet has an important impact on risk of CRC. Multiple epidemiological studies have suggested that excessive animal protein and fat intake, especially red meat and processed meat, could increase the risk of developing CRC while fiber could protect against colorectal tumorigenesis...
April 30, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29705770/post-treatment-surveillance-testing-of-patients-with-colorectal-cancer-and-the-association-with-survival-protocol-for-a-retrospective-cohort-study-of-the-surveillance-epidemiology-and-end-results-seer-medicare-database
#13
Robert B Hines, Md Jibanul Haque Jiban, Kanak Choudhury, Victoria Loerzel, Adrian V Specogna, Steven P Troy, Shunpu Zhang
INTRODUCTION: Although the colorectal cancer (CRC) mortality rate has significantly improved over the past several decades, many patients will have a recurrence following curative treatment. Despite this high risk of recurrence, adherence to CRC surveillance testing guidelines is poor which increases cancer-related morbidity and potentially, mortality. Several randomised controlled trials (RCTs) with varying surveillance strategies have yielded conflicting evidence regarding the survival benefit associated with surveillance testing...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29699921/monte-carlo-study-of-out-of-field-exposure-in-carbon-ion-radiotherapy-with-a-passive-beam-organ-doses-in-prostate-cancer-treatment
#14
Shunsuke Yonai, Naruhiro Matsufuji, Keiichi Akahane
PURPOSE: The aim of this work was to estimate typical dose equivalents to out-of-field organs during carbon-ion radiotherapy (CIRT) with a passive beam for prostate cancer treatment. Additionally, sensitivity analyses of organ doses for various beam parameters and phantom sizes were performed. METHODS: Because the CIRT out-of-field dose depends on the beam parameters, the typical values of those parameters were determined from statistical data on the target properties of patients who received CIRT at the Heavy-Ion Medical Accelerator in Chiba (HIMAC)...
April 23, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29695234/cost-effectiveness-and-budget-impact-analyses-of-a-colorectal-cancer-screening-programme-in-a-high-adenoma-prevalence-scenario-using-miscan-colon-microsimulation-model
#15
Arantzazu Arrospide, Isabel Idigoras, Javier Mar, Harry de Koning, Miriam van der Meulen, Myriam Soto-Gordoa, Jose Miguel Martinez-Llorente, Isabel Portillo, Eunate Arana-Arri, Oliver Ibarrondo, Iris Lansdorp-Vogelaar
BACKGROUND: The Basque Colorectal Cancer Screening Programme began in 2009 and the implementation has been complete since 2013. Faecal immunological testing was used for screening in individuals between 50 and 69 years old. Colorectal Cancer in Basque country is characterized by unusual epidemiological features given that Colorectal Cancer incidence is similar to other European countries while adenoma prevalence is higher. The object of our study was to economically evaluate the programme via cost-effectiveness and budget impact analyses with microsimulation models...
April 25, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29675660/rates-of-prevalent-colorectal-cancer-occurrence-in-persons-75-years-of-age-and-older-a-population-based-national-study
#16
Vijit Chouhan, Emad Mansoor, Sravanthi Parasa, Gregory S Cooper
BACKGROUND/AIMS: There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, population-based database as this may impact screening guidelines in this population. METHODS: Utilizing a commercial database (Explorys Inc, Cleveland, OH), we identified a cohort of patients with a first-ever diagnosis of CRC between 2012 and 2017 based on the Systematized Nomenclature of Medicine-Clinical Terms...
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671617/oxazole-and-thiazole-analogs-of-sulindac-for-cancer-prevention
#17
Bini Mathew, Judith V Hobrath, Michele C Connelly, R Kiplin Guy, Robert C Reynolds
AIM: Experimental and epidemiological studies and clinical trials suggest that nonsteroidal anti-inflammatory drugs possess antitumor potential. Sulindac, a widely used nonsteroidal anti-inflammatory drug, can prevent adenomatous colorectal polyps and colon cancer, especially in patients with familial adenomatous polyposis. Sulindac sulfide amide (SSA) is an amide-linked sulindac sulfide analog that showed in vivo antitumor activity in a human colon tumor xenograft model. Results/methodology: A new analog series with heterocyclic rings such as oxazole or thiazole at the C-2 position of sulindac was prepared and screened against prostate, colon and breast cancer cell lines to probe the effect of these novel substitutions on the activity of sulindac analogs...
April 19, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29667174/impact-of-prior-cancer-history-on-the-overall-survival-of-patients-newly-diagnosed-with-cancer-a-pan-cancer-analysis-of-the-seer-database
#18
Huaqiang Zhou, Yan Huang, Zeting Qiu, Hongyun Zhao, Wenfeng Fang, Yunpeng Yang, Yuanyuan Zhao, Xue Hou, Yuxiang Ma, Shaodong Hong, Ting Zhou, Yaxiong Zhang, Li Zhang
The population of cancer survivors with prior cancer is rapidly growing. Whether a prior cancer diagnosis interferes with outcome is unknown. We conducted a pan-cancer analysis to determine the impact of prior cancer history for patients newly diagnosed with cancer. We identified 20 types of primary solid tumors between 2004 to 2008 in the Surveillance, Epidemiology, and End Results (SEER) database. Demographic and clinicopathologic variables were compared by chi-squared test and t-test as appropriate. The propensity score-adjusted Kaplan-Meier method and Cox proportional hazards models were used to evaluate the impact of prior cancer on overall survival (OS)...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29665621/on-the-analysis-of-discrete-time-competing-risks-data
#19
Minjung Lee, Eric J Feuer, Jason P Fine
Regression methodology has been well developed for competing risks data with continuous event times, both for the cause-specific hazard and cumulative incidence functions. However, in many applications, including those from the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute, the event times may be observed discretely. Naive application of continuous time regression methods to such data is not appropriate. We propose maximum likelihood inferences for estimation of model parameters for the discrete time cause-specific hazard functions, develop predictions for the associated cumulative incidence functions, and derive consistent variance estimators for the predicted cumulative incidence functions...
April 17, 2018: Biometrics
https://www.readbyqxmd.com/read/29658575/differences-between-carcinoma-of-the-cecum-and-ascending-colon-evidence-based-on-clinical-and-embryological-data
#20
Xin Xie, Zhangjian Zhou, Yongchun Song, Wei Wang, Chengxue Dang, Hao Zhang
Developing rapidly from the cecal diverticulum in a 5-week-old embryo, the cecum, which is developed from the caudal limb of the midgut loop, is different from the ascending colon. The aim of this study was to analyze the different clinicopathological and biological characteristics of patients with carcinoma of the cecum and ascending colon. We accessed data for 59,035 patients with adenocarcinomas of the cecum and ascending colon from the Surveillance, Epidemiology and End Results database to explore the potential associations between the clinicopathological characteristics and overall survival...
April 12, 2018: International Journal of Oncology
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