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Colon cancer epidemiology

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https://www.readbyqxmd.com/read/29344654/tunicamycin-inhibits-colon-carcinoma-growth-and-aggressiveness-via-modulation-of-the-erk-jnk-mediated-akt-mtor-signaling-pathway
#1
Shuping You, Weihong Li, Yun Guan
Epidemiology and evidence have demonstrated that colon carcinoma is one of the most common gastrointestinal tumors in the clinic. Reports have suggested that Tunicamycin significantly inhibits aggressiveness of colon carcinoma cells by promotion of apoptosis. In the present study, the inhibitory effect of tunicamycin on colon cancer cells and the potential underlying molecular mechanism was investigated. Western blotting, immunohistochemistry, apoptotic assays and immunofluorescence were used to analyze the therapeutic effects of tunicamycin on apoptosis, growth, aggressiveness and cell cycle of colon tumor cells, by downregulation of fibronectin, vimentin and E‑cadherin expression levels...
January 17, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29342230/metformin-as-an-anti-cancer-agent-actions-and-mechanisms-targeting-cancer-stem-cells
#2
Nipun Saini, Xiaohe Yang
Metformin, a first line medication for type II diabetes, initially entered the spotlight as a promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk and improved clinical outcomes in diabetic patients taking metformin. To uncover the anti-cancer mechanisms of metformin, preclinical studies determined that metformin impairs cellular metabolism and suppresses oncogenic signaling pathways, including receptor tyrosine kinase, PI3K/Akt, and mTOR pathways. Recently, the anti-cancer potential of metformin has gained increasing interest due to its inhibitory effects on cancer stem cells (CSCs), which are associated with tumor metastasis, drug resistance, and relapse...
October 7, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29342165/increased-colon-cancer-risk-after-severe-salmonella-infection
#3
Lapo Mughini-Gras, Michael Schaapveld, Jolanda Kramers, Sofie Mooij, E Andra Neefjes-Borst, Wilfrid van Pelt, Jacques Neefjes
BACKGROUND: Colon cancer constitutes one of the most frequent malignancies. Previous studies showed that Salmonella manipulates host cell signaling pathways and that Salmonella Typhimurium infection facilitates colon cancer development in genetically predisposed mice. This epidemiological study examined whether severe Salmonella infection, usually acquired from contaminated food, is associated with increased colon cancer risk in humans. METHODS AND FINDINGS: We performed a nationwide registry-based study to assess colon cancer risk after diagnosed Salmonella infection...
2018: PloS One
https://www.readbyqxmd.com/read/29330379/identification-of-shared-genetic-variants-between-schizophrenia-and-lung-cancer
#4
Verena Zuber, Erik G Jönsson, Oleksandr Frei, Aree Witoelar, Wesley K Thompson, Andrew J Schork, Francesco Bettella, Yunpeng Wang, Srdjan Djurovic, Olav B Smeland, Ingrid Dieset, Ayman H Fanous, Rahul S Desikan, Sébastien Küry, Stéphane Bézieau, Anders M Dale, Ian G Mills, Ole A Andreassen
Epidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there is a shared genetic architecture between schizophrenia and cancer, with the aim to identify specific overlapping genetic loci. First, we performed genome-wide enrichment analysis and second, we analyzed specific loci jointly associated with schizophrenia and cancer by the conjunction false discovery rate...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317745/preventive-and-promotive-effects-of-habitual-hot-spa-bathing-on-the-elderly-in-japan
#5
Toyoki Maeda, Koshi Mimori, Sadao Suzuki, Takahiko Horiuchi, Naoki Makino
Although body-warming with hot spa-bathing has been proposed to exert medical therapeutic effects on certain diseases, whether body-warming has preventive and promotive effects remains unknown. To clarify this issue, an epidemiological questionnaire study regarding personal hot spa-bathing habits and disease history was carried out in Japan, where individuals engage in daily warm water bathing. Questionnaires regarding hot spa-bathing habits and disease history were randomly sent to 20,000 residents aged ≥65 years living in Beppu, a city in Japan that has the highest concentration of hot spa sources in the world...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317052/iron-therapy-as-treatment-of-anemia-a-potentially-detrimental-and-hazardous-strategy-in-colorectal-cancer-patients
#6
M J Wilson, J J Harlaar, J Jeekel, M Schipperus, J J Zwaginga
In colorectal cancer patients, iron therapy, and especially intravenous iron therapy, is increasingly used to treat anemia and reduce the use of blood transfusions. However, iron has also been shown to be an essential nutrient for rapidly proliferating tissues and cells. In this respect, anemia of inflammation, characterized by limited duodenal iron uptake and sequestration of iron into the reticuloendothelial system, might be regarded as a potentially effective defense strategy of the human body against tumor growth...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29313183/predictors-of-unknown-cancer-in-patients-with-ischemic-stroke
#7
Sonia Quintas, Jacobo Rogado, Pedro Gullón, Vilma Pacheco-Barcia, Julio Dotor García-Soto, Gemma Reig-Roselló, Rebeca Mondéjar, Ramón Colomer, Jose Vivancos
Stroke is the second most frequent neurologic finding in postmortem studies of cancer patients. It has also been described as the first expression of an occult cancer. We have studied patients diagnosed with cancer after an ischemic stroke (IS) and we analyze differences with non-tumor patients. Single cohort longitudinal retrospective study of patients admitted to our center with IS diagnosis from 1 January 2012 to 12 December 2014. All patients were followed for 18 months. Patients with transient ischemic infarction or cerebral hemorrhage, active cancer or in the last 5 years, inability to follow-up or absence of complete complementary study (holter-EKG, echocardiogram, and dupplex/angiography-CT) were excluded...
January 8, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29311051/relationship-between-state-level-google-online-search-volume-and-cancer-incidence-in-the-united-states-retrospective-study
#8
Charles A Phillips, Allison Barz Leahy, Yimei Li, Marilyn M Schapira, L Charles Bailey, Raina M Merchant
BACKGROUND: In the United States, cancer is common, with high morbidity and mortality; cancer incidence varies between states. Online searches reflect public awareness, which could be driven by the underlying regional cancer epidemiology. OBJECTIVE: The objective of our study was to characterize the relationship between cancer incidence and online Google search volumes in the United States for 6 common cancers. A secondary objective was to evaluate the association of search activity with cancer-related public events and celebrity news coverage...
January 8, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29310582/identification-of-uncommon-oral-yeasts-from-cancer-patients-by-maldi-tof-mass-spectrometry
#9
Narges Aslani, Ghasem Janbabaei, Mahdi Abastabar, Jacques F Meis, Mahasti Babaeian, Sadegh Khodavaisy, Teun Boekhout, Hamid Badali
BACKGROUND: Opportunistic infections due to Candida species occur frequently in cancer patients because of their inherent immunosuppression. The aim of the present study was to investigate the epidemiology of yeast species from the oral cavity of patients during treatment for oncological and haematological malignancies. METHODS: MALDI-TOF was performed to identify yeasts isolated from the oral cavity of 350 cancer patients. Moreover, antifungal susceptibility testing was performed in according to CLSI guidelines (M27-A3)...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29244630/epidemiology-and-outcomes-of-bloodstream-infections-in-patients-with-solid-tumors-in-a-central-american-population-at-mexico-hospital-san-jose-costa-rica
#10
Jorge Calvo-Lon, Denis U Landaverde, Allan Ramos-Esquivel, Juan M Villalobos-Vindas
Purpose Bloodstream infections (BSIs) are an important cause of mortality in patients with solid tumors. We conducted a retrospective study to evaluate the epidemiologic profile and mortality of patients with solid tumors who have BSIs and were admitted to Mexico Hospital. This is the first study in Costa Rica and Central America describing the current epidemiologic situation. Methods We analyzed the infectious disease database for BSIs in patients with solid tumors admitted to Mexico Hospital from January 2012 to December 2014...
December 15, 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29238222/the-burden-of-selected-cancers-in-the-us-health-behaviors-and-health-care-resource-utilization
#11
Laura Iadeluca, Jack Mardekian, Pratibha Chander, Markay Hopps, Geoffrey T Makinson
Objective: To characterize the disease burden among survivors of those cancers having the highest incidence in the US. Methods: Adult (≥18 years) survivors of the 11 most frequently diagnosed cancers were identified from publically available data sources, including the Surveillance Epidemiology and End Results 9 1973-2012, National Health Interview Survey 2013, and the Medical Expenditure Panel Survey 2011. Chi-square tests and one-way analyses of variance were utilized to assess differences between cancer survivors and non-cancer controls in behavioral characteristics, symptoms and functions, preventative screenings, and health care costs...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29233694/insight-of-nitric-oxide-signalling-a-potential-biomarker-in-bio-regulation-with-multifaceted-complex-mechanism-in-colorectal-carcinogenesis
#12
Paramita Mandal
Colorectal carcinogenesis (CRC) is the most important health concerns throughout the World as the tumour cells rapidly spread and abruptly grow in colon and rectum to further organs. Several etiological factors are associated with colorectal carcinogenesis. During invasion and proliferation of tumour cells, various mechanistic molecular pathways are involved in the cells. Nitric Oxide pathway (NO) is one of the important cellular mechanisms associated with tumour cells initiation, invasion and progression. Epidemiological evidences suggest that NO has potential role in development of cancer...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29230377/clinical-significance-of-circulating-immune-cells-in-left-and-right-sided-colon-cancer
#13
Jiabo Di, Meng Zhuang, Hong Yang, Beihai Jiang, Zaozao Wang, Xiangqian Su
Background: Left-sided and right-sided colon cancers (LCCs and RCCs, respectively) differ in their epidemiology, pathogenesis, genetic and epigenetic alterations, molecular pathways and prognosis. Notably, immune response gene expression profiles have been shown to differ between patients with LCC and patients with RCC. The immune system plays an important role in tumor immunosurveillance, and there is increasing evidence that peripheral blood immune cells have a profound influence on tumor prognosis...
2017: PeerJ
https://www.readbyqxmd.com/read/29198492/adequate-lymph-node-evaluation-in-the-elderly-is-associated-with-improved-survival-in-patients-with-stage-i-iii-colon-cancer-a-validation-study-using-the-national-cancer-data-base
#14
Jeffrey Reha, Shiva Kumar Reddy Mukkamalla, Ritesh Rathore, Ponnandai Sadasivan Somasundar
BACKGROUND: Lymph node involvement (LNI) is an important prognostic factor in colon cancer. But, variations in LNI among different age groups are less known. Adequate lymph node evaluation (LNE) requires assessment of ≥12 nodes. In our previous study, using Surveillance, Epidemiology and End Results (SEER) data, we demonstrated that older patients are less likely to have LNI (Khan et al. 2014). Our current study validates those findings using National Cancer Data Base (NCDB). METHODS: NCDB was queried for patients diagnosed with stages I-III colon adenocarcinoma from 2004 to 2008 who underwent surgical resections...
November 23, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29194365/the-role-of-resveratrol-in-cancer-therapy
#15
REVIEW
Jeong-Hyeon Ko, Gautam Sethi, Jae-Young Um, Muthu K Shanmugam, Frank Arfuso, Alan Prem Kumar, Anupam Bishayee, Kwang Seok Ahn
Abstract: Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven diseases, including cancer. A significant amount of research, including preclinical, clinical, and epidemiological studies, has indicated that dietary consumption of polyphenols, found at high levels in cereals, pulses, vegetables, and fruits, may prevent the evolution of an array of diseases, including cancer. Cancer development is a carefully orchestrated progression where normal cells acquires mutations in their genetic makeup, which cause the cells to continuously grow, colonize, and metastasize to other organs such as the liver, lungs, colon, and brain...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29190993/whether-partial-colectomy-is-oncologically-safe-for-patients-with-transverse-colon-cancer-a-large-population-based-study
#16
Xu Guan, Zhixun Zhao, Ming Yang, Haipeng Chen, Wei Chen, Zheng Liu, Zheng Jiang, Yinggang Chen, Guiyu Wang, Xishan Wang
Due to special tumor location and technical difficulty of transverse colon cancer (TCC), partial colectomy (PC) is being widely applied in selected TCC patients, instead of extended hemicolectomy (HC). However, the oncological safety of this less aggressive surgical approach is not well studied. Here, we identified 10344 TCC patients from Surveillance, Epidemiology, and End-Results (SEER) database. The surgical treatment for those patients included PC and HC. Firstly, we compared lymph nodes evaluations between patients treated with HC and PC, including median number of nodes, the rate of nodes ≥ 12 and the rate of node positivity...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29184688/age-and-factors-associated-with-access-and-time-to-post-operative-adjuvant-chemotherapy-in-colon-cancer-a-french-epidemiological-study
#17
Jean Capsec, Carole Lefebvre, Fabienne Chupé, Patrick Heitzmann, Céline Raveneau, Véronique Dardaine-Giraud, Carine Sauger, Jean-Paul Lagasse, Kevin Kraft, Claude Linassier, Etienne Dorval
Background: Studies have shown the negative prognostic impact of increased time between colectomy and postoperative adjuvant chemotherapy (AC) in colon cancer (CC). Our aim was to investigate the role of age and non-organizational factors on access and time to AC. Methods: All adult patients undergoing surgery for stage II or III CC in the "Région Centre-Val de Loire" in 2013, were selected. Time to AC and socio-demographic factors were collected. Logistic regression modeling was used to identify factors associated with access to AC, and a multivariate analysis performed to identify factors associated with time to AC...
October 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29179513/the-impacts-of-surgery-of-the-primary-cancer-and-radiotherapy-on-the-survival-of-patients-with-metastatic-rectal-cancer
#18
Duo Tong, Fei Liu, Wenhua Li, Wen Zhang
The role of surgery of the primary cancer and radiation in metastatic colorectal cancer (mCRC) is still controversial currently, and evidence implied that colon cancer (CC) and rectal cancer (RC) should be treated with difference. Hence we focused on metastatic rectal cancer (mRC) solely to compare the cancer cause-specific survival (CSS) of patients receiving varied treatments of the primary cancer: no treatment, surgery only, radiation only, and surgery plus radiation, based on the records of the Surveillance, Epidemiology, and End Results (SEER) database...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29168934/challenging-a-dogma-five-year-survival-does-not-equal-cure-in-all-colorectal-cancer-patients
#19
Omar Abdel-Rahman
BACKGROUND: The current study tried to evaluate the factors affecting 10- to 20- years' survival among long term survivors (>5 years) of colorectal cancer (CRC). METHODS: Surveillance, Epidemiology and End Results (SEER) database (1988-2008) was queried through SEER*Stat program.Univariate probability of overall and cancer-specific survival was determined and the difference between groups was examined. Multivariate analysis for factors affecting overall and cancer-specific survival was also conducted...
November 26, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29166866/the-risk-and-survival-outcome-of-subsequent-primary-colorectal-cancer-after-the-first-primary-colorectal-cancer-cases-from-1973-to-2012
#20
Jiao Yang, Xianglin L Du, Shuting Li, Yinying Wu, Meng Lv, Danfeng Dong, Lingxiao Zhang, Zheling Chen, Biyuan Wang, Fan Wang, Yanwei Shen, Enxiao Li, Min Yi, Jin Yang
BACKGROUND: Among colorectal cancer (CRC) survivors, how the prior tumor location affects the risk of subsequent primary colorectal cancer (SPCRC) and the outcome of those suffering from SPCRC remain unknown. METHODS: CRC cases diagnosed from 1973 to 2012 were screened for SPCRC development using the Surveillance, Epidemiology, and End Results database. The relative risk of SPCRC was estimated using the standardized incidence ratio. Survivals were analyzed using the Kaplan-Meier and Cox regression model...
November 22, 2017: BMC Cancer
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