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Diabetes mellitus/type 2

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https://www.readbyqxmd.com/read/29684904/excess-hospitalization-expenses-attributable-to-type-2-diabetes-mellitus-in-singapore
#1
May Ee Png, Joanne Yoong, Chuen Seng Tan, Kee Seng Chia
OBJECTIVES: To estimate the excess hospitalization expenses attributable to type 2 diabetes mellitus (T2DM) in a high-income Asian country from the health system perspective and the patient perspective. METHODS: Electronic medical records from a tertiary academic hospital in Singapore from 2012 to 2013 were used to create propensity score-matched cohorts with and without T2DM on the basis of their entry characteristics. A two-part model was then used to control for remaining differences between the cohorts...
April 20, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29684619/preventing-type-2-diabetes-and-cardiovascular-disease-in-women-with-gestational-diabetes-the-evidence-and-potential-strategies
#2
REVIEW
Graziano Di Cianni, Emilia Lacaria, Cristina Lencioni, Veronica Resi
Gestational Diabetes Mellitus is a condition strongly related to the development of type 2 diabetes later in life, although the risk and the onset have not been fully identified yet. Although glucose tolerance returns to normal levels after delivery in the majority of women with GDM, this condition represents an early stage in the natural history of T2DM. In addition, women with previous GDM exhibit an increased cardiovascular risk profile and a raised incidence of cardiovascular diseases. Lifestyle changes and pharmacological interventions might be able to reduce the incidence of type 2 diabetes in pGDM women, although results are still not conclusive...
April 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29684616/serum-fibrinogen-predicts-diabetic-esrd-in-patients-with-type-2-diabetes-mellitus
#3
Junlin Zhang, Yiting Wang, Rui Zhang, Hanyu Li, Qianqian Han, Yucheng Wu, Shanshan Wang, Ruikun Guo, Tingli Wang, Li Li, Fang Liu
AIMS: Although increased serum fibrinogen level was often observed in patients with diabetic nephropathy (DN), its association with DN severity and progression remains unclear. The aim of this study was to investigate the relationship between the serum fibrinogen levels and clinicopathological features and renal prognosis in Chinese patients with type 2 diabetes mellitus (T2DM) and DN. METHODS: A total of 174 patients with T2DM and biopsy-proven DN were enrolled...
April 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29684505/protective-effects-of-sulforaphane-on-cognitive-impairments-and-ad-like-lesions-in-diabetic-mice-are-associated-with-the-upregulation-of-nrf2-transcription-activity
#4
Die Pu, Yuxing Zhao, Jinliang Chen, Yue Sun, Ankang Lv, Shiyu Zhu, Cheng Luo, Kexiang Zhao, Qian Xiao
Type 2 diabetes mellitus (T2DM)-associated oxidative stress contributes to cognitive deficiencies and Alzheimer's disease (AD). Sulforaphane (SFN) is a pharmacological activator of Nrf2 that provokes Nrf2-mediated intracellular defenses, including antioxidant and anti-inflammatory responses, under oxidative stress (OS) conditions. This study investigated the effects of SFN on DM-related cognitive decline and its potential mechanisms. Morris water maze (MWM) tests showed that SFN (1 mg/kg i.p. for 28 days) mitigated the cognitive decline of db/db mice, a transgenic mouse model of T2DM...
April 20, 2018: Neuroscience
https://www.readbyqxmd.com/read/29684298/the-efficacy-of-selected-bariatric-surgery-methods-on-lipid-and-glucose-metabolism-a-retrospective-12-month-study
#5
Marek Bužga, Petra Marešová, Karin Petřeková, Pavol Holéczy, Kamil Kuča
OBJECTIVE: Approximately 25% of the Czech population is currently obese. Obesity rates are expected to increase in the future. Obesity not only raises the risk of health complications for individuals, but increasing rates also represent a significant and steadily growing economic burden for healthcare systems and society as a whole. The aim of this study was to evaluate the therapeutic efficacy of three methods of bariatric surgery: laparoscopic greater curve plication (LGCP), laparoscopic sleeve gastrectomy (LSG), and Roux-en-Y gastric bypass (RYBG) in patients with type 2 diabetes mellitus (DM)...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29684031/computationally-identified-novel-agonists-for-gprc6a
#6
Min Pi, Karan Kapoor, Ruisong Ye, Dong-Jin Hwang, Duane D Miller, Jeremy C Smith, Jerome Baudry, L Darryl Quarles
New insights into G protein coupled receptor regulation of glucose metabolism by β-cells, skeletal muscle and liver hepatocytes identify GPRC6A as a potential therapeutic target for treating type 2 diabetes mellitus (T2D). Activating GPRC6A with a small molecule drug represents a potential paradigm-shifting opportunity to make significant strides in regulating glucose homeostasis by simultaneously correcting multiple metabolic derangements that underlie T2D, including abnormalities in β-cell proliferation and insulin secretion and peripheral insulin resistance...
2018: PloS One
https://www.readbyqxmd.com/read/29683909/acog-committee-opinion-no-734-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#7
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683904/acog-committee-opinion-no-734-summary-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#8
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683361/human-recombinant-epidermal-growth-factor-in-skin-lesions-77-cases-in-epitelizando-project
#9
Jordi Esquirol-Caussa, Elisabeth Herrero-Vila
OBJECTIVE: To analyze compounded recombinant human Epidermal Growth Factor (rhEGF) effectiveness on skin lesions through a case series. DESIGN: Multicentric series of skin lesions treated with topical recombinant human Epidermal Growth Factor. SITE: Patients from 56 different health professionals, three different countries, two recruitment years. PARTICIPANTS: 77 patients with skin lesions, mean age 63.15 years (min = 18, max = 95); 53...
April 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29683271/piperine-promotes-glucose-uptake-through-ros-dependent-activation-of-the-camkk-ampk-signaling-pathway-in-skeletal-muscle
#10
Ayumi Maeda, Takeshi Shirao, Daishi Shirasaya, Yasukiyo Yoshioka, Yoko Yamashita, Mitsugu Akagawa, Hitoshi Ashida
SCOPE: The prevalence of type 2 diabetes mellitus (T2DM) is increasing yearly worldwide. Glycemic control is the basis for the treatment of T2DM, as it can prevent the progress of associated complications. Spices possess various health beneficial effects on humans. The aim of this study was to search for spices that can promote glucose uptake and to elucidate the underlying molecular mechanism(s). METHODS AND RESULTS: Among 24 spice extracts, the extracts from black and white pepper significantly increased glucose uptake in L6 myotubes...
April 23, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29683100/pioglitazone-therapy-and-fractures-systematic-review-and-meta-analysis
#11
Velichka Pavlova, Elena Filipova, Katya Uzunova, Krassimir Kalinov, Toni Vekov
INTRODUCTION: Thiazolidinediones are group of synthetic medications used in type 2 diabetes treatment. Among available thiazolidinediones pioglitazone is gaining increased attention due to its lower cardiovascular risk in type 2 diabetes mellitus sufferers and seems a promising future therapy. Accumulating evidence suggests that diabetic patients may exert bone fractures due to such treatments. Simultaneously, female population is thought to be at greater risk. Still the safety outcomes of pioglitazone treatment especially in terms of fractures are questionable and need to be clarified...
April 23, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29682579/glomerular-filtration-rate-and-or-ratio-of-urine-albumin-to-creatinine-as-markers-for-diabetic-retinopathy-a-ten-year-follow-up-study
#12
Pedro Romero-Aroca, Marc Baget-Bernaldiz, Raul Navarro-Gil, Antonio Moreno-Ribas, Aida Valls-Mateu, Ramon Sagarra-Alamo, Joan F Barrot-De La Puente, Xavier Mundet-Tuduri
Aims: To determine the relationship between diabetic nephropathy and diabetic retinopathy on a population of type 2 diabetes mellitus patients. Methods: A prospective ten-year follow-up population-based study. We determined differences between estimated glomerular filtration rate (eGFR) using the chronic kidney disease epidemiology collaboration equation and urine albumin to creatinine ratio. Results: Annual incidence of any-DR was 8.21 ± 0...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29682177/chemerin-induces-endothelial-cell-inflammation-activation-of-nuclear-factor-kappa-beta-and-monocyte-endothelial-adhesion
#13
Georgios K Dimitriadis, Jaspreet Kaur, Raghu Adya, Alexander D Miras, Harman S Mattu, John G Hattersley, Gregory Kaltsas, Bee K Tan, Harpal S Randeva
Chemerin, a chemoattractant protein, acts via a G-protein coupled chemokine receptor, i.e. Chemokine like Receptor 1/ChemR23; levels of which are elevated in pro-inflammatory states such as obesity and type 2 diabetes mellitus (T2DM). Obesity and T2DM patients are at high risk of developing cardiovascular disorders such as atherosclerosis. We have reported that chemerin induces human endothelial cell angiogenesis and since dysregulated angiogenesis and endothelial dysfunction are hallmarks of vascular disease; we sought to determine the effects of chemerin on monocyte-endothelial adhesion, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a critical pro-inflammatory transcription factor...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29682104/predictors-of-perioperative-stroke-death-after-carotid-artery-stenting-a-review-article
#14
REVIEW
Ali F AbuRahma
Carotid artery stenting (CAS) has been recommended as an alternative treatment to carotid endarterectomy for patients with significant carotid stenosis. Only a few studies have analyzed clinical/anatomical and technical variables that affect perioperative outcomes of CAS. Following a comprehensive Medline search, it was reported that clinical factors, including age of >80 years, chronic renal failure, diabetes mellitus, symptomatic indications, and procedures performed within 2 weeks of transient ischemic attack symptoms, are associated with high perioperative stroke and death rates...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29682103/cardiovascular-disease-in-japanese-patients-with-type-2-diabetes-mellitus
#15
REVIEW
Kazuya Fujihara, Hirohito Sone
Individuals with diabetes have a two- to four-fold increased risk of coronary artery disease (CAD) and higher mortality rates than those without diabetes. Because not only microvascular but also macrovascular disease in patients with diabetes are known to predispose patients to a lower quality of life as well as lead to higher mortality rates, identifying and managing risk factors of CAD is of clinical relevance in diabetes care. A number of antihyperglycemic drugs are currently approved for the treatment of hyperglycemia in patients with type 2 diabetes mellitus (T2DM), with several new drugs having been developed during the last decade...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29681991/the-relationship-between-mnsod-val16ala-gene-polymorphism-and-the-level-of-serum-total-antioxidant-capacity-with-the-risk-of-chronic-kidney-disease-in-type-2-diabetic-patients-a-nested-case-control-study-in-the-tehran-lipid-glucose-study
#16
Mehrnaz Abbasi, Maryam S Daneshpour, Mehdi Hedayati, Azadeh Mottaghi, Katayoun Pourvali, Fereidoun Azizi
Background: Several studies have shown significant associations between manganese superoxide dismutase (MnSOD) Val16Ala polymorphism and diabetic complications, but this association has not been explored in relation with chronic kidney disease (CKD) in Type 2 diabetes mellitus (T2DM) patients. Total antioxidant capacity (TAC) level changes in diabetic condition and may play important role in onset or progression of the disease and its complications. The present study investigated the association of MnSOD Val16Ala polymorphism and serum TAC with the risk of CKD in T2DM patients...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29681852/genotypic-and-phenotypic-factors-influencing-drug-response-in-mexican-patients-with-type-2-diabetes-mellitus
#17
Hector E Sanchez-Ibarra, Luisa M Reyes-Cortes, Xian-Li Jiang, Claudia M Luna-Aguirre, Dionicio Aguirre-Trevino, Ivan A Morales-Alvarado, Rafael B Leon-Cachon, Fernando Lavalle-Gonzalez, Faruck Morcos, Hugo A Barrera-Saldaña
The treatment of Type 2 Diabetes Mellitus (T2DM) consists primarily of oral antidiabetic drugs (OADs) that stimulate insulin secretion, such as sulfonylureas (SUs) and reduce hepatic glucose production (e.g., biguanides), among others. The marked inter-individual differences among T2DM patients' response to these drugs have become an issue on prescribing and dosing efficiently. In this study, fourteen polymorphisms selected from Genome-wide association studies (GWAS) were screened in 495 T2DM Mexican patients previously treated with OADs to find the relationship between the presence of these polymorphisms and response to the OADs...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29680417/gender-specific-independent-and-combined-dose-response-association-of-napping-and-night-sleep-duration-with-type-2-diabetes-mellitus-in-rural-chinese-adults-the-ruraldiab-study
#18
Ruihua Liu, Yuqian Li, Zhenxing Mao, Xiaotian Liu, Haiqing Zhang, Kaili Yang, Honglei Zhang, Runqi Tu, Xinling Qian, Jingjing Jiang, Ronghai Bie, Chongjian Wang
OBJECTIVE: The aim of this study was to explore the independent and combined dose-response association of napping and night sleep duration with type 2 diabetes mellitus (T2DM) among different genders in the rural Chinese population. METHODS: For this research, a total of 19,257 participants were enrolled in the Rural Diabetes, Obesity and Lifestyle (RuralDiab) study. Napping and night sleep duration were assessed using the Pittsburgh Sleep Quality Index (PSQI). Restricted cubic splines and logistic regression were used to estimate the relationship between napping and night sleep duration with T2DM...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29680319/comrade-a-randomized-trial-of-an-individually-tailored-integrated-care-intervention-for-uncontrolled-type-2-diabetes-with-depression-and-or-distress-in-the-rural-southeastern-us
#19
Lesley D Lutes, Doyle M Cummings, Kerry Littlewood, Chelsey Solar, Marissa Carraway, Kari Kirian, Shivajirao Patil, Alyssa Adams, Stefanie Ciszewski, Bertha Hambidge
BACKGROUND: Emerging evidence suggests that people living with Type 2 diabetes mellitus (T2D) are also at greater risk for depression and distress. If left untreated, these comorbid mental health concerns can have long-lasting impacts on medical and physical health outcomes. DESIGN: This prospective trial randomized rural men and women with uncontrolled T2D (HbA1c ≥ 7.0) who screened positive for co-morbid depressive (PHQ-2 > 3) or distress (DDS-2 > 3) symptoms in a primary medical care setting to receive either: 1) 16 sessions of cognitive and/or behavioral intervention tailored to symptom severity across 12 months along with routine medical care, or 2) usual primary care...
April 19, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29679925/tocotrienol-rich-fraction-supplementation-reduces-hyperglycemia-induced-skeletal-muscle-damage-through-regulation-of-insulin-signaling-and-oxidative-stress-in-type-2-diabetic-mice
#20
Heaji Lee, Yunsook Lim
Chronic hyperglycemia induces impairment of muscle growth and development of diabetes mellitus (DM). Since skeletal muscle is the major site for disposal of ingested glucose, impaired glucose metabolism causes imbalance between protein synthesis and degradation which adversely affects physical mobility. In this study, we investigated the effect of tocotrienol-rich fraction (TRF) supplementation on skeletal muscle damage in diabetic mice. Diabetes was induced by a high-fat diet with streptozotocin (STZ) injection (100 mg/kg) in male C57BL/6J mice...
March 21, 2018: Journal of Nutritional Biochemistry
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