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https://www.readbyqxmd.com/read/28915894/cardiovascular-risk-in-patients-with-alpha-1-antitrypsin-deficiency
#1
Sebastian Fähndrich, Frank Biertz, Annika Karch, Björn Kleibrink, Armin Koch, Helmut Teschler, Tobias Welte, Hans-Ulrich Kauczor, Sabina Janciauskiene, Rudolf A Jörres, Timm Greulich, Claus F Vogelmeier, Robert Bals
BACKGROUND: Alpha-1-antitrypsin deficiency (AATD) is a rare inherited condition caused by mutations of the SERPINA1 gene that is associated with the development of a COPD like lung disease. The comorbidities in patients with AATD-related lung diseases are not well defined. The aim of this study was to analyze the clinical phenotype of AATD patients within the German COPD cohort study COSYCONET ("COPD and SYstemic consequences-COmorbidities NETwork") cohort focusing on the distribution of comorbidities...
September 15, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28910817/the-lung-in-dysregulated-states-of-humoral-immunity
#2
Yurdagül Uzunhan, Florence Jeny, Marianne Kambouchner, Morgane Didier, Diane Bouvry, Hilario Nunes, Jean-François Bernaudin, Dominique Valeyre
In common variable immunodeficiency, lung manifestations are related to different mechanisms: recurrent pneumonias due to encapsulated bacteria responsible for diffuse bronchiectasis, diffuse infiltrative pneumonia with various patterns, and lymphomas, mostly B cell extranodal non-Hodgkin type. The diagnosis relies on significant serum Ig deficiency and the exclusion of any primary or secondary cause. Histopathology may be needed. Immunoglobulin (IgG) replacement is crucial to prevent infections and bronchiectasis...
September 15, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28910509/the-experience-of-palliative-care-service-provision-for-people-with-non-malignant-respiratory-disease-and-their-family-carers-an-all-ireland-qualitative-study
#3
Clare Mc Veigh, Joanne Reid, Philip Larkin, Sam Porter, Peter Hudson
AIM: To explore specialist and generalist palliative care provision for people with non-malignant respiratory disease, in rural and urban areas in the North and Republic of Ireland. BACKGROUND: Globally, palliative care is recommended as an appropriate healthcare option for people with advanced non- malignant lung disease. Yet, there is limited evidence regarding the integration of palliative care for this client group. DESIGN: Qualitative study...
September 14, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28898770/immunoglobulin-replacement-therapy-in-primary-and-secondary-antibody-deficiency-the-correct-clinical-approach
#4
REVIEW
Antonio Pecoraro, Ludovica Crescenzi, Francescopaolo Granata, Arturo Genovese, Giuseppe Spadaro
Immunoglobulin therapy is the administration of human polyvalent IgG and represents the most effective treatment to prevent recurrent infections in antibody deficiency patients. Primary antibody deficiency represents the main indication of immunoglobulin replacement therapy and includes a wide range of disorders characterized by impaired antibody production in response to pathogens and recurrent infections. However, not all primary antibody deficiency patients require immunoglobulin replacement. Indeed, immunoglobulin preparations are expensive and, once prescribed, usually result in lifelong therapy...
September 9, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28894613/pneumonia-due-to-a-rare-pathogen-achromobacter-xylosoxidans-subspecies-denitrificans
#5
Hesham Awadh, Munthir Mansour, Obadah Aqtash, Yousef Shweihat
Achromobacter xylosoxidans, subspecies denitrificans, is a gram-negative rod recently implicated as an emerging cause of infection in both immunosuppressed and immunocompetent populations. Few cases are reported in literature involving multiple body systems. Diagnosis depends on cultures of appropriate specimens, and management usually is by administration of appropriate antibiotics (usually agents with antipseudomonal activity). We report a rare case of pneumonia due to infection with this organism, in a patient with preexisting bronchiectasis secondary to chronic aspiration...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28894480/patient-participation-in-ers-guidelines-and-research-projects-the-embarc-experience
#6
REVIEW
James D Chalmers, Alan Timothy, Eva Polverino, Marta Almagro, Thomas Ruddy, Pippa Powell, Jeanette Boyd
The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) is a European Respiratory Society (ERS) Clinical Research Collaboration dedicated to improving research and clinical care for people with bronchiectasis. EMBARC has created a European Bronchiectasis Registry, funded by the ERS and by the European Union (EU) Innovative Medicines Initiative Programme. From the outset, EMBARC had the ambition to be a patient-focussed project. In contrast to many respiratory diseases, however, there are no specific patient charities or European patient organisations for patients with bronchiectasis and no existing infrastructure for patient engagement...
September 2017: Breathe
https://www.readbyqxmd.com/read/28894479/the-european-multicentre-bronchiectasis-audit-and-research-collaboration-embarc-experiences-from-a-successful-ers-clinical-research-collaboration
#7
REVIEW
James D Chalmers, Megan Crichton, Pieter C Goeminne, Michael R Loebinger, Charles Haworth, Marta Almagro, Montse Vendrell, Anthony De Soyza, Raja Dhar, Lucy Morgan, Francesco Blasi, Stefano Aliberti, Jeanette Boyd, Eva Polverino
In contrast to airway diseases like chronic obstructive pulmonary disease or asthma, and rare diseases such as cystic fibrosis, there has been little research and few clinical trials in bronchiectasis. Guidelines are primarily based on expert opinion and treatment is challenging because of the heterogeneous nature of the disease. In an effort to address decades of underinvestment in bronchiectasis research, education and clinical care, the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) was established in 2012 as a collaborative pan-European network to bring together bronchiectasis researchers...
September 2017: Breathe
https://www.readbyqxmd.com/read/28891169/computed-tomographic-findings-in-three-dogs-naturally-infected-with-crenosoma-vulpis
#8
Jeremy R Mortier, Caroline J Fina, Elsa Edery, Crystal L White, Marc P Dhumeaux
Crenosoma vulpis is a nematode lungworm found in wild and domestic canids in some parts of North America and Europe. Reported radiographic findings are nonspecific and consist of a combination of bronchial and interstitial changes of variable severity. This retrospective, case series study aimed to describe thoracic computed tomographic (CT) findings for a group of dogs with confirmed crenosomosis. Selection criteria were presentation with a chronic cough during the period of January 2016 to February 2017, evaluation by thoracic CT, and final diagnosis of C...
September 10, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28889896/bronchiectasis-complicating-lung-volume-reduction-coil-treatment
#9
Marie Pierre Debray, Armelle Marceau, Marie Christine Dombret, Vincent Bunel, Sylvie Leroy, Gaëtan Deslée, Hervé Mal
Endoscopic lung volume reduction has emerged over the past several years as a promising technique to improve the respiratory functional status of patients with advanced emphysema. Nevertheless, the procedure may be associated with various complications; among them, the development of bronchiectasis related to the coils has not yet been described. We report the case of a patient with emphysema who developed localized bronchiectasis at the site of coil insertion several months after lung volume reduction coil treatment...
September 2017: Chest
https://www.readbyqxmd.com/read/28889110/european-respiratory-society-guidelines-for-the-management-of-adult-bronchiectasis
#10
Eva Polverino, Pieter C Goeminne, Melissa J McDonnell, Stefano Aliberti, Sara E Marshall, Michael R Loebinger, Marlene Murris, Rafael Cantón, Antoni Torres, Katerina Dimakou, Anthony De Soyza, Adam T Hill, Charles S Haworth, Montserrat Vendrell, Felix C Ringshausen, Dragan Subotic, Robert Wilson, Jordi Vilaró, Bjorn Stallberg, Tobias Welte, Gernot Rohde, Francesco Blasi, Stuart Elborn, Marta Almagro, Alan Timothy, Thomas Ruddy, Thomy Tonia, David Rigau, James D Chalmers
Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent exacerbations in many patients. There have been no previous international guidelines.The European Respiratory Society guidelines for the management of adult bronchiectasis describe the appropriate investigation and treatment strategies determined by a systematic review of the literature.A multidisciplinary group representing respiratory medicine, microbiology, physiotherapy, thoracic surgery, primary care, methodology and patients considered the most relevant clinical questions (for both clinicians and patients) related to management of bronchiectasis...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28887201/reactive-oxygen-therapy-a-novel-antimicrobial
#11
REVIEW
Matthew Dryden
The main solution to the global antibiotic resistance crisis is reducing the volume of antibiotic use in medicine, agriculture and the environment. However there is also a pressing need for novel antimicrobials. Despite much rhetoric, there are few entirely novel agents in development. One such therapy to reach clinical use is an agent using Reactive Oxygen Species (ROS), oxygen radicals, as an antimicrobial mechanism. ROS can be delivered to the site of infection in various formats. ROS is highly antimicrobial against Gram positive and negative bacteria, viruses and fungi...
September 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28886040/residual-volume-total-lung-capacity-ratio-confers-limited-additive-significance-to-lung-clearance-index-for-assessment-of-adults-with-bronchiectasis
#12
Wei-Jie Guan, Jing-Jing Yuan, Yan Huang, Hui-Min Li, Rong-Chang Chen, Nan-Shan Zhong
BACKGROUND: Mosaicism and hyperinflation are common pathophysiologic features of bronchiectasis. The magnitude of ventilation heterogeneity might have been affected by the degree of hyperinflation. Some studies have evaluated the discriminative performance of lung clearance index (LCI) in bronchiectasis patients, but the additive diagnostic value of hyperinflation metrics to LCI is unknown. OBJECTIVE: To compare LCI and the ratio of residual volume to total lung capacity (RV/TLC), along with the LCI normalized with RV/TLC, in terms of discriminative performance, correlation and concordance with clinical variables in adults with bronchiectasis...
2017: PloS One
https://www.readbyqxmd.com/read/28884072/ochroconis-gallopava-bronchitis-mimicking-haemoptysis-in-a-patient-with-bronchiectasis
#13
M Bernasconi, C Voinea, P M Hauser, L P Nicod, R Lazor
Ochroconis gallopava is an anamorphic mould characterized by slow growth rate and production of a maroon pigment, which has been isolated worldwide from soil, thermal springs, decaying vegetation, and chicken litter. It has been reported to cause localized, mostly pulmonary, and systemic infection in severely immunocompromised patients. We describe the case of a 76-year-old woman known for ulcerative colitis-related bronchiectasis treated with low dose oral steroids, who developed a fungal bronchitis with dark, bloody-like, sputum which was initially misinterpreted as haemoptysis...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28883249/pneumonitis-with-diffuse-alveolar-hemorrhage-induced-by-sho-seiryu-to
#14
Kazuo Tsuchiya, Mikio Toyoshima, Takafumi Suda
A 78-year-old man presented with acute-onset fever and dyspnea. He had been taking Sho-seiryu-to for allergic rhinitis. A chest radiograph showed diffuse bilateral ground-glass opacities with subpleural sparing, crazy-paving pattern, and traction bronchiectasis. The patient's bronchoalveolar lavage fluid was bloody and transbronchial lung biopsy specimens showed alveolitis, organizing pneumonia, and type 2 alveolar epithelial cell proliferation. There were no clinical and laboratory findings suggestive of respiratory tract infection or connective tissue disease...
September 6, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28881106/quantitative-assessment-of-airway-dimensions-in-young-children-with-cystic-fibrosis-lung-disease-using-chest-computed-tomography
#15
Wieying Kuo, Thomas Soffers, Eleni-Rosalina Andrinopoulou, Tim Rosenow, Sarath Ranganathan, Lidija Turkovic, Stephen M Stick, Harm A W M Tiddens
OBJECTIVE: To evaluate lung disease progression using airway and artery (AA) dimensions on chest CT over 2-year interval in young CF patients longitudinally and compare to disease controls cross-sectionally. METHODS: Retrospective analysis of pressure controlled end-inspiratory CTs, 12 routine baseline (CT1 ) and follow up (CT2 ) from AREST CF cohort; 12 disease controls with normal CT. All visible AA-pairs were measured perpendicular to the airway axis. Inner and outer airway diameters and wall (outer-inner radius) thickness were divided by adjacent arteries to compute Ain A-, Aout A-, and AWT A-ratios, respectively...
September 7, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28870218/respiratory-problems-in-children-with-esophageal-atresia-and-tracheoesophageal-fistula
#16
Federica Porcaro, Laura Valfré, Lelia Rotondi Aufiero, Luigi Dall'Oglio, Paola De Angelis, Alberto Villani, Pietro Bagolan, Sergio Bottero, Renato Cutrera
BACKGROUND: Children with congenital esophageal atresia (EA) and tracheoesophageal fistula (TEF) have chronic respiratory symptoms including recurrent pneumonia, wheezing and persistent cough. The aim of this study is to describe the clinical findings of a large group of children with EA and TEF surgically corrected and the instrumental investigation to which they have undergone in order to better understand the patient's needs and harmonize the care. METHODS: A retrospective data collection was performed on 105 children with EA and TEF followed at Department of Pediatric Medicine of Bambino Gesù Children's Hospital (Rome, Italy) between 2010 and 2015...
September 5, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28869119/does-home-based-pulmonary-rehabilitation-improve-functional-capacity-peripheral-muscle-strength-and-quality-of-life-in-patients-with-bronchiectasis-compared-to-standard-care
#17
Anderson José, Anne E Holland, Cristiane S de Oliveira, Jessyca P R Selman, Rejane A S de Castro, Rodrigo A Athanazio, Samia Z Rached, Alberto Cukier, Rafael Stelmach, Simone Dal Corso
BACKGROUND: Home-based pulmonary rehabilitation is a promising intervention that may help patients to overcome the barriers to undergoing pulmonary rehabilitation. However, home-based pulmonary rehabilitation has not yet been investigated in patients with bronchiectasis. OBJECTIVES: To investigate the effects of home-based pulmonary rehabilitation in patients with bronchiectasis. METHODS: An open-label, randomized controlled trial with 48 adult patients with bronchiectasis will be conducted...
August 19, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28867755/successful-treatment-of-three-patients-with-organizing-pneumonia-associated-with-rheumatoid-arthritis-using-clarithromycin-and-prednisolone
#18
Masashi Ohe, Haruki Shida, Tetsuya Horita, Kenichiro Ito, Mitsuru Sugiura, Atsuo Hattori, Kenji Oku
Macrolides have anti-inflammatory effects and have been used to treat diffuse panbronchiolitis, bronchiectasis, and cystic fibrosis. Lately, several cases of cryptogenic organizing pneumonia (COP) and radiotherapy-related organizing pneumonia (OP) that were successfully treated with macrolides considering their anti-inflammatory effects were reported. We report three cases of OP associated with rheumatoid arthritis (RA) successfully treated with clarithromycin (CAM) and prednisolone (PSL). Case 1: A 70-year-old woman suffering from RA was admitted with cough and severe dyspnea...
2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28866642/the-quantitative-link-of-lung-clearance-index-to-bronchial-segments-affected-by-bronchiectasis
#19
Sylvia Verbanck, Gregory G King, Wenxiao Zhou, Anne Miller, Cindy Thamrin, Daniel Schuermans, Bart Ilsen, Caroline W Ernst, Johan de Mey, Walter Vincken, Eef Vanderhelst
In adult patients with cystic fibrosis (CF), the lung clearance index (LCI) derived from the multiple breath washout relates to both acinar and conductive ventilation heterogeneity. The latter component predicts an association between LCI and the number of bronchial segments affected by bronchiectasis. Here, we experimentally demonstrated this association in patients with CF, and also examined an ancillary group of patients with non-CF bronchiectasis. We conclude that lung disease severity in terms of number of bronchial segments results in an associated LCI increase, likely constituting a portion of LCI that cannot be reversed by treatment in patients with CF lung disease...
September 2, 2017: Thorax
https://www.readbyqxmd.com/read/28863927/the-role-of-non-invasive-modalities-for-assessing-inflammation-in-patients-with-non-cystic-fibrosis-bronchiectasis
#20
Stamatoula Tsikrika, Katerina Dimakou, Andriana I Papaioannou, Georgios Hillas, Loukas Thanos, Kostantinos Kostikas, Stelios Loukides, Spyros Papiris, Nickolaos Koulouris, Petros Bakakos
INTRODUCTION: Bronchiectasis is a heterogeneous entity, taking into account clinical characteristics, inflammatory response, effectiveness of treatment and frequency of exacerbations. In stable state non-cystic fibrosis (non-CF) bronchiectasis, little is known about non-invasive techniques used for evaluating airway inflammation in obstructive airway diseases. OBJECTIVES: We sought to evaluate the associations between induced sputum and clinical/radiologic characteristics, and the differences between biomarkers expressing Th1 and Th2 response in patients with non-CF bronchiectasis and to compare our findings with a previously studied population of patients with asthma and COPD...
August 29, 2017: Cytokine
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