Rui Tian, Ping Zhou, Mengyuan Li, Jinfeng Tan, Zifeng Cui, Wei Xu, Jingyue Wei, Jingjing Zhu, Zhuang Jin, Chen Cao, Weiwen Fan, Weiling Xie, Zhaoyue Huang, Hongxian Xie, Zeshan You, Gang Niu, Canbiao Wu, Xiaofang Guo, Xuchu Weng, Xun Tian, Fubing Yu, Zhiying Yu, Jiuxing Liang, Zheng Hu
Human papillomavirus (HPV) integrating into human genome is the main cause of cervical carcinogenesis. HPV integration selection preference shows strong dependence on local genomic environment. Due to this theory, it is possible to predict HPV integration sites. However, a published bioinformatic tool is not available to date. Thus, we developed an attention-based deep learning model DeepHPV to predict HPV integration sites by learning environment features automatically. In total, 3608 known HPV integration sites were applied to train the model, and 584 reviewed HPV integration sites were used as the testing dataset...
October 16, 2020: Briefings in Bioinformatics