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de-cellularised scaffold

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https://www.readbyqxmd.com/read/29048769/in-vivo-implantation-of-a-tissue-engineered-stem-cell-seeded-hemi-laryngeal-replacement-maintains-airway-phonation-and-swallowing-in-pigs
#1
P Herrmann, T Ansari, A Southgate, A Varanou Jenkins, L Partington, C Carvalho, S Janes, M Lowdell, P Sibbons, M A Birchall
BACKGROUND: Laryngeal functional impairment relating to swallowing, vocalisation and respiration can be life changing and devastating for patients. A tissue engineering approach to regenerating vocal folds would represent a significant advantage over current clinical practice. METHOD: Porcine hemi-larynx were de-cellularised under negative pressure. The resultant acellular scaffold was seeded with human bone marrow derived mesenchymal stem cells and primary human epithelial cells...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28360084/the-revitalisation-of-flexor-tendon-allografts-with-bone-marrow-stromal-cells-and-mechanical-stimulation-an-ex-vivo-model-revitalising-flexor-tendon-allografts
#2
J H Wu, A R Thoreson, A Gingery, K N An, S L Moran, P C Amadio, C Zhao
OBJECTIVES: The present study describes a novel technique for revitalising allogenic intrasynovial tendons by combining cell-based therapy and mechanical stimulation in an ex vivo canine model. METHODS: Specifically, canine flexor digitorum profundus tendons were used for this study and were divided into the following groups: (1) untreated, unprocessed normal tendon; (2) decellularised tendon; (3) bone marrow stromal cell (BMSC)-seeded tendon; and (4) BMSC-seeded and cyclically stretched tendon...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/26797607/lung-regeneration-endogenous-and-exogenous-stem-cell-mediated-therapeutic-approaches
#3
REVIEW
Khondoker M Akram, Neil Patel, Monica A Spiteri, Nicholas R Forsyth
The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration. Disruption in this process results in healing by fibrosis causing aberrant lung remodelling and organ dysfunction. Post-insult failure of regeneration leads to various incurable lung diseases including chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis...
January 19, 2016: International Journal of Molecular Sciences
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