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https://www.readbyqxmd.com/read/27909499/hyperacute-and-chronic-changes-in-cerebral-magnetic-resonance-images-after-pvac-nmarq-and-epicardial-thoracoscopic-surgical-ablation-for-paroxysmal-atrial-fibrillation
#1
Conn Sugihara Mbbs, Neil Barlow Mbbs, Emma Owens Mbbs, David Sallomi Mb ChB, Neil Sulke Md
Threshold testing of cardiac rhythm devices is essential to monitoring the proper functioning of such devices (1). However, the currently method of applying multiple ECG leads to the patient is burdensome and time consuming (2). We are presenting a completely new way to perform cardiac rhythm device threshold testing using pulse oximetry. Twenty patients, with varying cardiac rhythm devices and pacing modes, were enrolled and had their atrial and ventricular thresholds tested. A comparison was made between simultaneous threshold determinations via the standard EGM based method and the new pulse oximetry based method...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27878420/a-5-year-clinical-follow-up-after-duty-cycled-phased-rf-ablation-of-paroxysmal-atrial-fibrillation
#2
Antoine Lepillier, Xavier Copie, Gilles Lascault, Olivier Paziaud, Olivier Piot
PURPOSE: Catheter radiofrequency ablation (RFA) is an effective treatment for symptomatic paroxysmal atrial fibrillation (AF). It has been demonstrated that the multielectrode pulmonary vein ablation catheter (PVAC) has favourable outcomes at 6-12 months post-ablation, but there are only few studies with a long-term follow-up. METHODS: We retrospectively reviewed 77 consecutive PVAC procedures in our centre, from November 2007 to December 2012. RFA was attempted in patients with symptomatic paroxysmal AF (mean age 58...
November 22, 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/27752967/effective-contact-and-outcome-after-pulmonary-vein-isolation-in%C3%A2-novel%C3%A2-circular-multi-electrode-atrial-fibrillation-ablation
#3
P Gal, T J Buist, J J J Smit, A Adiyaman, A R Ramdat Misier, P P H M Delnoy, A Elvan
INTRODUCTION: Pulmonary vein (PV) reconnection is frequently the cause of recurrence of atrial fibrillation (AF) after ablation. The second-generation gold multi-electrode ablation (Gold-MEA) catheter has a new design possibly resulting in improved lesion formation compared with its predecessor. We aimed to determine the association between effective radiofrequency applications with the Gold-MEA catheter and outcome after AF ablation. METHODS: 50 consecutive patients with paroxysmal AF underwent Gold-MEA (PVAC GOLD(TM), Medtronic Inc...
October 17, 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27702508/miscanthus-giganteus-a-commercially-viable-sustainable-source-of-cellulose-nanocrystals
#4
Elvis Cudjoe, Mo Hunsen, Zhaojun Xue, Amanda E Way, Elizabeth Barrios, Rebecca A Olson, Michael J A Hore, Stuart J Rowan
With a goal of identifying a new scalable source for cellulose nanocrystals (CNCs), we successfully isolated CNCs from a sustainable, non-invasive grass, Miscanthus x. Giganteus (MxG). Subjecting MxG stalks to base hydrolysis, bleaching and acid hydrolysis allowed access to cellulose nanocrystals (MxG-CNC) in high yields. X-ray diffraction studies showed the crystallinity of the MxG-CNCs increased with subsequent treatment conditions (>90% after HCl hydrolysis). Transmission electron microscopy showed that the MxG-CNC exhibit relatively high aspect ratios (60-70), and small angle neutron scattering showed the crystals were ribbon-like with a width and thickness of 8...
January 2, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27486993/separation-of-water-from-ultralow-sulfur-diesel-using-novel-polymer-nanofiber-coated-glass-fiber-media
#5
Stuti S Rajgarhia, Sadhan C Jana, George G Chase
Polymer nanofibers with interpenetrating network (IPN) morphology are used in this work for the development of composite, hydrophobic filter media in conjunction with glass fibers for removal of water droplets from ultralow sulfur diesel (ULSD). The nanofibers are produced from hydrophobic polyvinyl acetate (PVAc) and hydrophilic polyvinylpyrrolidone (PVP) by spinning the polymer solutions using gas jet fiber (GJF) method. The nanofibers coat the individual glass fibers due to polar-polar interactions during the spinning process and render the filter media highly hydrophobic with a water contact angle approaching 150°...
August 24, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27414755/reduced-crystallization-temperature-methodology-for-polymer-selection-in-amorphous-solid-dispersions-stability-perspective
#6
Chandan Bhugra, Chitra Telang, Robert Schwabe, Li Zhong
API-polymer interactions, used to select the right polymeric matrix with an aim to stabilize an amorphous dispersion, are routinely studied using spectroscopic and/or calorimetric techniques (i.e., melting point depression). An alternate selection tool has been explored to rank order polymers for formation of stable amorphous dispersions as a pragmatic method for polymer selection. Reduced crystallization temperature of API, a parameter introduced by Zhou et al.,1 was utilized in this study for rank ordering interactions in API-polymeric systems...
September 6, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27377397/simple-rapid-and-cost-effective-fabrication-of-pdms-electrophoresis-microchips-using-poly-vinyl-acetate-as-photoresist-master
#7
Eulício O Lobo-Júnior, Ellen F M Gabriel, Rodrigo A Dos Santos, Fabrício R de Souza, Wanderson D Lopes, Renato S Lima, Angelo L Gobbi, Wendell K T Coltro
This study describes a simple, rapid and cost-effective fabrication of PDMS electrophoresis microchips using poly(vinyl acetate) (PVAc) emulsion as photoresist master. High-relief microfluidic structures were defined on PVAc previously deposited on printed circuit boards (PCB) surfaces without cleanroom facilities and sophisticated instrumentation. After a UV exposure, channels with heights ranging from 30 to 140 μm were obtained by controlling the emulsion mass deposited on the master surface. The developing stage was performed using water rather than the organic solvents that are applied for conventional masks...
July 4, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27327662/influence-of-clinical-parameters-and-anticoagulation-on-intraprocedural-cerebral-microembolic-signals-during-pulmonary-vein-isolation
#8
Robert Larbig, Ralf Dittrich, Simon Kochhaeuser, Patrick Leitz, Fatih Guener, Catharina Korsukewitz, Dirk Dechering, Christian Pott, Kristina Wasmer, Jan Schmitges, Monika Kerckhoff, Lars Eckardt, Gerold Moennig
OBJECTIVE: We had the objective to determine the impact of clinical parameters and anticoagulation status on cerebral microembolic signals (MES) during pulmonary vein isolation (PVI) for atrial fibrillation (AF). BACKGROUND: Thromboembolism and stroke are the most feared complications of PVI. MES can help to evaluate embolic burden. It is unknown whether clinical parameters have an impact on embolic risk during PVI. METHODS: In this retrospective analysis we investigated the impact of clinical parameters, including the CHADS2- and CHA2DS2-VASc-score, pulmonary vein variants and echocardiographic parameters on MES rates in patients that underwent PVI using three different ablation approaches (radiofrequency ablation (iRF), pulmonary vein ablation catheter (PVAC) with deactivated electrode pair 1 or 5 (PVAC-red) or PVAC without deactivation (PVAC-all)...
2016: PloS One
https://www.readbyqxmd.com/read/27230934/first-results-and-follow-up-of-a-second-generation-circular-mapping-and-ablation-catheter
#9
Stefan Weber, Martin Höher, Dominik Schultes
PURPOSE: Pulmonary vein isolation with radiofrequency energy is widely used as a strategy for catheter ablation of atrial fibrillation (AF). Anatomically designed catheters have been developed to increase the efficiency of AF ablation procedures. The second-generation circular ablation catheter, PVAC GOLD, was re-designed to improve energy delivery and mitigate emboli. We investigated the procedural efficiency, biophysics, and chronic efficacy of PVAC GOLD in patients with AF. METHODS: We consecutively enrolled 40 patients (60 ± 11 years) with highly symptomatic, drug refractory AF...
May 26, 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/27220967/spatial-distribution-of-electrical-reconnection-after-pulmonary-vein-isolation-in-patients-with-recurrent-paroxysmal-atrial-fibrillation
#10
L M Rademakers, I Romero, T A Simmers, P H van der Voort, A M Meijer, L R Dekker
INTRODUCTION: Recurrence of atrial fibrillation after pulmonary vein isolation (PVI) occurs frequently and may be associated with electrical reconnection of the pulmonary veins (PV). We investigated spatial distribution of electrical reconnection during re-do procedures in patients with paroxysmal atrial fibrillation who had previous successful acute electrical PVI with either single irrigated tip, antral ablation (s-RF; n = 38) or multi-electrode, duty-cycled ablation (PVAC; n = 48)...
July 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/26954494/support-vector-machine-based-on-microrna-expression-profiles-to-predict-histological-origin-of-ampullary-carcinoma-case-report-of-a-patient-affected-from-adenocarcinoma-of-the-papilla-of-vater-with-lynch-syndrome
#11
Francesca Tavano, Massimiliano Copetti, Ada Piepoli, Massimo Carella, Annamaria Gentile, Francesca Paola Burbaci, Andrea Fontana, Antonio De Bonis, Fabio Francesco di Mola, Pierluigi di Sebastiano, Angelo Andriulli
Adenocarcinomas of Vater's papilla (PVAC) may originate from either the pancreatic duct or the intestinal epithelium. Conflicting data have been reported about the frequency of the 2 anatomical entities and their influence on patients' prognosis. To ascertain the anatomical origin of PVAC in a family member of a Lynch syndrome kindred, we searched for microRNA (miRNA) expression profiles on resected tumor specimens. The support vector machine was trained on our previous miRNAs expression data sets of pancreatic and colorectal tissue samples and used to classify the site of origin of the tumor in our patient...
April 2016: Pancreas
https://www.readbyqxmd.com/read/26921762/predictability-of-lesion-durability-for-af-ablation-using-phased-radiofrequency-power-temperature-and-duration-impact-creation-of-transmural-lesions
#12
Mélèze Hocini, Cathy Condie, Mark T Stewart, Nicole Kirchhof, Jason D Foell
BACKGROUND: Long-term clinical outcomes for atrial fibrillation ablation depend on the creation of durable transmural lesions during pulmonary vein isolation and on substrate modification. Focal conventional radiofrequency (RF) ablation studies have demonstrated that tissue temperature and power are important factors for lesion formation. However, the impact and predictability of temperature and power on contiguous, transmural lesion formation with a phased RF system has not been described...
July 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/26921761/lower-rate-of-left-atrial-tachycardia-after-pulmonary-vein-isolation-with-pvac-versus-irrigated-tip-circumferential-antral-ablation
#13
Kristina Wasmer, David Krüsemann, Patrick Leitz, Fatih Güner, Christian Pott, Stephan Zellerhoff, Dirk Dechering, Julia Köbe, Philipp S Lange, Lars Eckardt, Gerold Mönnig
BACKGROUND: Left atrial tachycardias (LAT) occur in about 5% of patients after irrigated-tip circumferential antral (CA) pulmonary vein isolation (PVI). They may cause debilitating symptoms in the patient and may be very difficult to treat. OBJECTIVE: To assess the incidence of LAT after PVI with the multielectrode phased-radiofrequency pulmonary vein ablation catheter (PVAC) compared to circumferential antral PVI with an irrigated-tip catheter. METHODS: We analyzed data from our ablation database...
August 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/26804625/effect-of-polymer-binders-on-uv-responsive-organic-thin-film-phototransistors-with-benzothienobenzothiophene-semiconductor
#14
Darko Ljubic, Chad S Smithson, Yiliang Wu, Shiping Zhu
The influence of polymer binders on the UV response of organic thin-film phototransistors (OTF-PTs) is reported. The active channel of the OTF-PTs was fabricated by blending a UV responsive 2,7-dipenty-[1]benzothieno[2,3-b][1]benzothiophene (C5-BTBT) as small molecule semiconductor and a branched unsaturated polyester (B-upe) as dielectric binder (ratio 1:1). To understand the influence of the polymer composition on the photoelectrical properties and UV response of C5-BTBT, control blends were prepared using common dielectric polymers, namely, poly(vinyl acetate) (PVAc), polycarbonate (PC), and polystyrene (PS), for comparison...
February 17, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26787365/cobalt-mediated-radical-polymerization-of-vinyl-acetate-and-acrylonitrile-in-supercritical-carbon-dioxide
#15
Anthony Kermagoret, Ngoc Do Quyen Chau, Bruno Grignard, Daniela Cordella, Antoine Debuigne, Christine Jérôme, Christophe Detrembleur
Cobalt-mediated radical polymerization (CMRP) of vinyl acetate (VAc) is successfully achieved in supercritical carbon dioxide (scCO2). CMRP of VAc is conducted using an alkyl-cobalt(III) adduct that is soluble in scCO2. Kinetics studies coupled to visual observations of the polymerization medium highlight that the melt viscosity and PVAc molar mass (Mn) are key parameters that affect the CMRP in scCO2. It is noticed that CMRP is controlled for Mn up to 10 000 g mol(-1), but loss of control is progressively observed for higher molar masses when PVAc precipitates in the polymerization medium...
March 2016: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/26644279/esophageal-and-mediastinal-lesions-following-multielectrode-duty-cycled-radiofrequency-pulmonary-vein-isolation-simple-equals-safe
#16
Stephan Zellerhoff, Frank Lenze, Hansjörg Ullerich, Alex Bittner, Kristina Wasmer, Julia Köbe, Christian Pott, Lars Eckardt, Gerold Mönnig
BACKGROUND: The development of esophageal lesions following atrial fibrillation (AF) ablation has frequently been reported. Mediastinal tissue layers and the posterior wall of the left atrium are in close proximity to the site of ablation. Hence, mucosal lesions might solely represent the "tip of the iceberg." We therefore investigated patients undergoing multielectrode phased radiofrequency (RF) ablation (PVAC®, Medtronic Inc., Minneapolis, MN, USA) for symptomatic AF by radial endosonography (EUS) in conjunction with conventional endoscopy esophago-gastro-duodenoscopy (EGD) to visualize potential mediastinal injuries following pulmonary vein isolation (PVI)...
April 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/26628175/highly-sensitive-pseudo-differential-ac-nanocalorimeter-for-the-study-of-the-glass-transition
#17
Mohcine Laarraj, Rahma Adhiri, Said Ouaskit, Mohamed Moussetad, Christophe Guttin, Jacques Richard, Jean-Luc Garden
We present a nanocalorimeter designed for the measurement of the dynamic heat capacity of thin films. The microfabricated sensor, the thermal conditioning of the sensor, as well as the highly stable and low noise electronic chain allow measurements of the real and imaginary parts of the complex specific heat with a resolution Δ C/C of about 10(-5). The performances of this quasi-differential nanocalorimeter were tested on a model of polymeric glass-former, the polyvinyl acetate (PVAc). The high stability and low noise of the device are essential for accurate studies on non-equilibrium slow relaxing systems such as glasses...
November 2015: Review of Scientific Instruments
https://www.readbyqxmd.com/read/26572400/nanofiller-for-the-mechanical-reinforcement-of-maltodextrins-orodispersible-films
#18
Ilaria Franceschini, Francesca Selmin, Stefania Pagani, Paola Minghetti, Francesco Cilurzo
One of the most critical quality attributes of orodispersible films (ODFs) is related to the development of dosage forms with tensile properties suitable for the packaging and patient's handling. Aiming to develop a strategy to reinforce the tensile properties, the current work reported the feasibility to improve the tensile strength of maltodextrins (MDX) based ODFs by adding an amorphous water insoluble nanofiller, namely polyvinylacetate (PVAc). The possible interactions between components investigated by DSC and ATR-FTIR spectroscopy revealed that MDX and PVAc were immiscible; even if, the presence of plasticizers permitted the homogeneous dispersion of PVAc in the film until the 10% w/w concentration was reached...
January 20, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/26552799/site-localization-of-painful-lesions-during-radiofrequency-ablation-of-pulmonary-veins-using-circular-multi-electrode-catheters
#19
Avishag Laish-Farkash, Amos Katz, Ornit Cohen, Azriel Osherov, Sharon Bruocha, Vladimir Khalameizer
PURPOSE: Previous data showed that pain sensation was common during pulmonary vein isolation (PVI) using an 8-mm radiofrequency (RF) ablation catheter. Pain was more common in the left pulmonary veins (PVs). We characterized the location of pain during PVI using circular multi-electrode ablation catheters. METHODS: Included are all consecutive patients with atrial fibrillation (AF) who underwent PVI using the phased RF PVAC® catheter (Medtronic) or the irrigated nMARQ™ catheter (Biosense Webster) under conscious sedation between July 2011 and March 2015...
January 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/26505077/strong-surface-treatment-effects-on-reinforcement-efficiency-in-biocomposites-based-on-cellulose-nanocrystals-in-poly-vinyl-acetate-matrix
#20
Farhan Ansari, Michaela Salajková, Qi Zhou, Lars A Berglund
In this work, the problem to disperse cellulose nanocrystals (CNC) in hydrophobic polymer matrices has been addressed through application of an environmentally friendly chemical modification approach inspired by clay chemistry. The objective is to compare the effects of unmodified CNC and modified CNC (modCNC) reinforcement, where degree of CNC dispersion is of interest. Hydrophobic functionalization made it possible to disperse wood-based modCNC in organic solvent and cast well-dispersed nanocomposite films of poly(vinyl acetate) (PVAc) with 1-20 wt % CNC...
December 14, 2015: Biomacromolecules
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