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https://www.readbyqxmd.com/read/28291050/medication-sharing-is-rare-among-african-hiv-1-serodiscordant-couples-enrolled-in-an-efficacy-trial-of-oral-pre-exposure-prophylaxis-prep-for-hiv-1-prevention
#1
Kerry A Thomson, Jessica E Haberer, Mark Marzinke, Andrew Mujugira, Craig Hendrix, Connie Celum, Patrick Ndase, Alan Ronald, David R Bangsberg, Jared M Baeten
Sharing of pre-exposure prophylaxis (PrEP) medications is a concern for PrEP implementation. For HIV-1 serodiscordant couples, sharing may undermine HIV-1 prevention benefits and also cause antiretroviral resistance if taken by HIV-1 infected partners. Within a PrEP efficacy trial among HIV-1 serodiscordant couples, we assessed the occurrence of PrEP sharing by self-report and plasma tenofovir concentrations in HIV-1 infected partners. PrEP sharing was self-reported at <0.01% of visits and 0-1.6% of randomly selected and 0% of purposively selected specimens from HIV-1 infected participants had detectable tenofovir concentrations (median: 66...
March 10, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28291047/the-impact-of-pre-exposure-prophylaxis-among-men-who-have-sex-with-men-an-individual-based-model
#2
Parastu Kasaie, Jeff Pennington, Maunank S Shah, Stephen A Berry, Danielle German, Colin P Flynn, Chris Beyrer, David W Dowdy
OBJECTIVES: Pre-exposure prophylaxis (PrEP) is recommended for preventing HIV infection among individuals at high risk, including men who have sex with men (MSM). Although its individual-level efficacy is proven, questions remain regarding population-level impact of PrEP implementation. DESIGN: We developed an agent-based simulation of HIV transmission among MSM, accounting for demographics, sexual contact network, HIV disease stage and use of antiretroviral therapy...
March 10, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28286983/stigma-medical-mistrust-and-perceived-racism-may-affect-prep-awareness-and-uptake-in-black-compared-to-white-gay-and-bisexual-men-in-jackson-mississippi-and-boston-massachusetts
#3
Sean Cahill, S Wade Taylor, Steven A Elsesser, Leandro Mena, DeMarc Hickson, Kenneth H Mayer
Gay and bisexual men and other men who have sex with men (MSM) account for more than two thirds of new HIV infections in the U.S., with Black MSM experiencing the greatest burden. Antiretroviral pre-exposure prophylaxis (PrEP) can reduce MSM's vulnerability to HIV infection. Uptake of PrEP has been limited, particularly among racial and ethnic minority MSM. Four semi-structured focus groups with gay and bisexual men and other MSM at risk for HIV infection were convened in Boston and Jackson in late 2013. The analysis plan utilized a within-case, across-case approach to code and analyze emerging themes, and to compare results across the two cities...
March 12, 2017: AIDS Care
https://www.readbyqxmd.com/read/28279949/usability-and-acceptability-of-a-mobile-comprehensive-hiv-prevention-app-for-men-who-have-sex-with-men-a-pilot-study
#4
Patrick S Sullivan, Robert Driggers, Joanne D Stekler, Aaron Siegler, Tamar Goldenberg, Sarah J McDougal, Jason Caucutt, Jeb Jones, Rob Stephenson
BACKGROUND: Men who have sex with men (MSM) are the group most impacted by the human immunodeficiency virus (HIV) epidemic and the only subgroup in the United States among which new HIV diagnoses are not decreasing. To achieve the US National HIV/AIDS (acquired immunodeficiency syndrome) Strategy goals of reducing new diagnoses by 25%, high (eg, 30-50%) coverage of multiple HIV prevention interventions is needed in both urban and rural areas. Mobile phone "apps" are an important channel through which prevention services could be provided at scale and at low marginal cost...
March 9, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28276922/science-technology-power-and-sex-prep-and-hiv-positive-gay-men-in-paris
#5
Julien Brisson, Vinh-Kim Nguyen
The pre-exposure prophylaxis (PrEP) drug Truvada is a new HIV prevention technology that is predominantly promoted as relevant to HIV-negative gay men. This paper explores what PrEP represents for HIV-positive gay men living in Paris, based upon data collected through interviews and ethnographic research. While HIV-positive gay men do not directly consume Truvada through PrEP, they nonetheless hold opinions and understandings of this drug, specifically as it relates to their own sexuality. This paper expands the representations and meanings of this new technology in a different light through the voices of gay men living with HIV in Paris...
February 21, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28274904/gender-specific-combination-hiv-prevention-for-youth-in-high-burden-settings-the-mp3-youth-observational-pilot-study-protocol
#6
Jasmine Buttolph, Irene Inwani, Kawango Agot, Charles M Cleland, Peter Cherutich, James N Kiarie, Alfred Osoti, Connie L Celum, Jared M Baeten, Ruth Nduati, John Kinuthia, Timothy B Hallett, Ramzi Alsallaq, Ann E Kurth
BACKGROUND: Nearly three decades into the epidemic, sub-Saharan Africa (SSA) remains the region most heavily affected by human immunodeficiency virus (HIV), with nearly 70% of the 34 million people living with HIV globally residing in the region. In SSA, female and male youth (15 to 24 years) are at a disproportionately high risk of HIV infection compared to adults. As such, there is a need to target HIV prevention strategies to youth and to tailor them to a gender-specific context. This protocol describes the process for the multi-staged approach in the design of the MP3 Youth pilot study, a gender-specific, combination, HIV prevention intervention for youth in Kenya...
March 8, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28271718/acceptability-of-microbicidal-vaginal-rings-and-oral-pre-exposure-prophylaxis-for-hiv-prevention-among-female-sex-workers-in-a-high-prevalence-us-city
#7
Sarah M Peitzmeier, Catherine Tomko, Erin Wingo, Anne Sawyer, Susan G Sherman, Nancy Glass, Chris Beyrer, Michele R Decker
Biomedical HIV prevention tools including oral pre-exposure prophylaxis (PrEP) and vaginal microbicidal rings hold unique value for high-risk women who may have limited capacity for condom negotiation, including the key populations of sex workers and drug users. Commercial sex is a PrEP indicator in CDC guidelines, yet little is known about female sex workers' (FSWs) knowledge of and attitudes toward PrEP or the recently developed monthly vaginal microbicide rings. We describe knowledge and attitudes toward PrEP and microbicide rings in a sample of 60 mostly drug-using FSWs in Baltimore, Maryland, a high HIV-prevalence US city...
March 8, 2017: AIDS Care
https://www.readbyqxmd.com/read/28260694/a-case-study-of-chewed-truvada-%C3%A2-for-prep-maintaining-protective-drug-levels-as-measured-by-a-novel-urine-tenofovir-assay
#8
Linden Lalley-Chareczko, Devon Clark, Athena F Zuppa, Ganesh Moorthy, Caitlin Conyngham, Karam Mounzer, Helen Koenig
FTC/TDF (Truvada®) given as pre-exposure prophylaxis (PrEP) successfully blocks HIV when taken once daily prior to potential HIV exposure. A 22 year old male reported difficulty swallowing FTC/TDF for PrEP and subsequently began chewing the FTC/TDF tablets. Monthly urine samples assessed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) indicated tenofovir levels >1000 ng/mL, indicative of protection from HIV acquisition, over a 48 week period. Data from observational studies of HIV positive patients details the successful treatment of HIV using crushed FTC/TDF delivered via feeding and gastronomy tubes while small, randomized trials of healthy volunteers demonstrate bioequivalence between whole and crushed FTC/TDF...
March 6, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28257475/awareness-and-attitudes-of-pre-exposure-prophylaxis-for-hiv-prevention-among-physicians-in-guatemala-implications-for-country-wide-implementation
#9
Ian Ross, Carlos Mejia, Johanna Melendez, Philip A Chan, Amy C Nunn, William Powderly, Katherine Goodenberger, Jingxia Liu, Kenneth H Mayer, Rupa R Patel
INTRODUCTION: HIV continues to be a major health concern with approximately 2.1 million new infections occurring worldwide in 2015. In Central America, Guatemala had the highest incident number of HIV infections (3,700) in 2015. Antiretroviral pre-exposure prophylaxis (PrEP) was recently recommended by the World Health Organization (WHO) as an efficacious intervention to prevent HIV transmission. PrEP implementation efforts are underway in Guatemala and success will require providers that are knowledgeable and willing to prescribe PrEP...
2017: PloS One
https://www.readbyqxmd.com/read/28253024/differences-in-cumulative-exposure-and-adherence-to-tenofovir-in-the-voice-iprex-ole-and-prep-demo-studies-as-determined-via-hair-concentrations
#10
Catherine A Koss, Peter Bacchetti, Sharon L Hillier, Edward Livant, Howard Horng, Nyaradzo Mgodi, Brenda G Mirembe, Kailazarid Gomez Feliciano, Stephanie Horn, Albert Y Liu, David V Glidden, Robert M Grant, Leslie Z Benet, Alexander Louie, Ariane van der Straten, Z Mike Chirenje, Jeanne M Marrazzo, Monica Gandhi
Pre-exposure prophylaxis (PrEP) with oral tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) prevented HIV acquisition among men and women in several trials and is broadly recommended. In the VOICE and FEM-PrEP trials, however, TDF/FTC-based PrEP did not prevent HIV acquisition among women in eastern and southern Africa. Tenofovir was detected in plasma, reflecting exposure and adherence in recent days, in fewer than one-third of participants. Drug concentrations in hair, which represent cumulative exposure and adherence over weeks to months, have never previously been examined among women on PrEP...
March 2, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28248625/raising-awareness-of-pre-exposure-prophylaxis-prep-among-women-in-new-york-city-community-and-provider-perspectives
#11
Kate L Collier, Lisa G Colarossi, Kim Sanders
This study explored the knowledge, attitudes, and perceived facilitators and barriers to adoption of HIV pre-exposure prophylaxis (PrEP) among black women and Latinas in the Bronx, NY. Data were collected in focus group discussions (FGDs) held separately with staff (n = 21) and black and Latina female clients aged 18 to 50 (n = 23) of four organizations providing health and social services. Participants were also asked to give feedback about four action messages regarding PrEP for a social marketing campaign...
March 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28238119/use-of-pre-exposure-prophylaxis-prep-in-young-men-who-have-sex-with-men-is-associated-with-race-sexual-risk-behavior-and-peer-network-size
#12
Lisa M Kuhns, Anna L Hotton, John Schneider, Robert Garofalo, Kayo Fujimoto
Pre-exposure prophylaxis (PrEP) is efficacious to prevent HIV infection, however, uptake among young men who have sex with men (YMSM) is relatively low. The purpose of this study was to describe PrEP use and related factors in a representative sample of YMSM in two cities, Chicago and Houston. YMSM, ages 16-29, were recruited via respondent-driven sampling (RDS) from 2014 to 2016. Correlates of PrEP uptake were assessed in weighted multivariable logistic regression models. A total of 12.2% of participants (of 394) reported ever taking PrEP; Black YMSM had the lowest rates of uptake (4...
February 25, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28236498/executive-summary-pre-exposure-prophylaxis-for-prevention-of-hiv-infection-in-adults-in-spain-july-2016
#13
Santiago Moreno, Antonio Antela, Felipe García, Julia Del Amo, Vicente Boix, Pep Coll, Claudia Fortuny, Juan L Gómez Sirvent, Félix Gutiérrez, José A Iribarren, Josep M Llibre, Juan C López Bernaldo de Quirós, Juan Emilio Losa, Ana Lozano, Michael Meulbroek, Julián Olalla, Ferran Pujol, Federico Pulido, Manuel Crespo Casal, Juan González García, José López Aldeguer, Jose A Pérez Molina, Daniel Podzamczer Palter, Antonio Rivero Román
Administration of antiretroviral drugs to individuals exposed to, but not infected by, HIV has been shown to reduce the risk of transmission. The efficacy of pre-exposure prophylaxis (PrEP) makes it obligatory to include it in an integral program of prevention of HIV transmission, together with other measures, such as use of the condom, training, counseling, and appropriate treatment of infected individuals. In this document, the AIDS Study Group (GeSIDA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica [SEIMC]) provides its views on this important subject...
February 21, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28222118/social-structural-behavioral-and-clinical-factors-influencing-retention-in-pre-exposure-prophylaxis-prep-care-in-mississippi
#14
Trisha Arnold, Lauren Brinkley-Rubinstein, Philip A Chan, Amaya Perez-Brumer, Estefany S Bologna, Laura Beauchamps, Kendra Johnson, Leandro Mena, Amy Nunn
Pre-exposure prophylaxis (PrEP) is a biomedical intervention that can reduce rates of HIV transmission when taken once daily by HIV-negative individuals. Little is understood about PrEP uptake and retention in care among the populations most heavily impacted by the HIV epidemic, particularly among young men who have sex with men (YMSM) in the Deep South. Therefore, this study explored the structural, social, behavioral, and clinical factors that affect PrEP use and retention in care among YMSM in Jackson, Mississippi...
2017: PloS One
https://www.readbyqxmd.com/read/28214391/correlates-of-willingness-to-initiate-pre-exposure-prophylaxis-and-anticipation-of-practicing-safer-drug-and-sex-related-behaviors-among-high-risk-drug-users-on-methadone-treatment
#15
Roman Shrestha, Pramila Karki, Frederick L Altice, Tania B Huedo-Medina, Jaimie P Meyer, Lynn Madden, Michael Copenhaver
BACKGROUND: Although people who use drugs (PWUD) are key populations recommended to receive pre-exposure prophylaxis (PrEP) to prevent HIV, few data are available to guide PrEP delivery in this underserved group. We therefore examined the willingness to initiate PrEP and the anticipation of HIV risk reduction while on PrEP among high-risk PWUD. METHODS: In a cross-sectional study of 400 HIV-negative, opioid dependent persons enrolled in a methadone program and reporting recent risk behaviors, we examined independent correlates of being willing to initiate PrEP...
February 2, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28209492/reproductive-considerations-in-the-setting-of%C3%A2-chronic-viral-illness
#16
REVIEW
Brent M Hanson, Jessie A Dorais
Special considerations must be taken when patients with human immunodeficiency virus (HIV), hepatitis B, or hepatitis C desire to become pregnant. Patients with chronic viral illnesses desire to have children at rates similar to the general population, and options are available to decrease both vertical transmission and viral transmission between partners. Preconception counseling or consultation with fertility specialists is imperative in patients with HIV, hepatitis B, and hepatitis C so that reproductive goals can be addressed and optimized...
February 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28208119/hiv-prevention-opportunities-and-challenges
#17
Jeanne M Marrazzo
Preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF)-based regimens has been shown to be effective in preventing acquisition of HIV infection, with protective efficacy being dependent on adherence to treatment. Data from the PROUD (Preexposure Option for Reducing HIV in the UK) and IPERGAY (Action to Prevent Risk Exposure By and For Gay Men) studies, the later of which employed event-driven PrEP, showed a high rate of protective efficacy of PrEP with TDF and emtricitabine among men who have sex with men...
December 2017: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/28187084/uptake-of-hiv-pre-exposure-prophylaxis-prep-in-a-national-cohort-of-gay-and-bisexual-men-in-the-united-states
#18
Jeffrey T Parsons, H Jonathon Rendina, Jonathan M Lassiter, Thomas H F Whitfield, Tyrel J Starks, Christian Grov
OBJECTIVES: The HIV care cascade provides milestones to track the progress of HIV-positive people from seroconversion through viral suppression. We propose a Motivational pre-exposure prophylaxis (PrEP) Cascade involving 5 stages based on the Transtheoretical Model of Change. METHODS: We analyzed data from 995 men in One Thousand Strong, a longitudinal study of a national panel of HIV-negative gay and bisexual men in the United States. RESULTS: Nearly all (89%) participants were sexually active in the past 3 months and 65% met Centers for Disease Control criteria for PrEP candidacy...
March 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28176168/a-global-estimate-of-the-acceptability-of-pre-exposure-prophylaxis-for-hiv-among-men-who-have-sex-with-men-a-systematic-review-and-meta-analysis
#19
Peng Peng, Shu Su, Christopher K Fairley, Minjie Chu, Shengyang Jiang, Xun Zhuang, Lei Zhang
Pre-exposure prophylaxis (PrEP) is a new biomedical intervention for HIV prevention. This study systematically reviews the acceptability of PrEP among men who have sex with men (MSM) worldwide. We searched major English databases to identify English-language articles published between July 2007 and July 2016, which reported the acceptability of PrEP and associated population characteristics. Meta-analysis was conducted to estimate a pooled acceptability, and meta-regression and subgroup analysis were used to analyse heterogeneities...
February 7, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28170424/generational-analysis-of-trends-in-unprotected-sex-in-france-among-men-who-have-sex-with-men-the-major-role-of-context-driven-evolving-patterns
#20
Nicolas Méthy, Laurence Meyer, Nathalie Bajos, Annie Velter
OBJECTIVE: Using a generational approach, this study analyses how unprotected anal intercourse has evolved since 1991 in France across different generations of men who have sex with men (MSM) whose sexual lives began at different periods in the history of the HIV epidemic. DESIGN: Data were collected from 18-59 year-old respondents to the French Gay Press surveys Enquêtes Presse Gay, conducted repeatedly between 1991 and 2011 (N = 32,196) using self-administered questionnaires distributed in gay magazines and over the internet...
2017: PloS One
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