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https://www.readbyqxmd.com/read/29780687/the-intention-to-use-hiv-pre-exposure-prophylaxis-prep-among-men-who-have-sex-with-men-in-switzerland-testing-an-extended-explanatory-model-drawing-on-the-unified-theory-of-acceptance-and-use-of-technology-utaut
#1
Sibylle Nideröst, Daniel Gredig, Benedikt Hassler, Franziska Uggowitzer, Patrick Weber
Aim: The aim of this study was to determine the intention to use pre-exposure prophylaxis (PrEP) when available and to identify predictors of the intention to use PrEP among men who have sex with men (MSM) living in Switzerland. The theoretical model drew on the Unified Theory of Acceptance and Use of Technology and considered additional variables related specifically to PrEP, HIV protection and the resources of MSM. Subject and methods: For data collection, we used an anonymous, standardized self-administered online questionnaire...
2018: Journal of Public Health
https://www.readbyqxmd.com/read/29770060/setting-the-stage-for-expanding-hiv-pre-exposure-prophylaxis-use-in-canada
#2
EDITORIAL
M Hull, Dhs Tan
Human immunodeficiency virus (HIV) infection continues to disproportionately affect vulnerable populations in Canada; particularly men who have sex with men (MSM). Novel HIV prevention strategies have recently expanded from the use of non-occupational post-exposure prophylaxis (nPEP) after high risk exposures to the use of pre-exposure prophylaxis (PrEP) in which individuals reduce risk of HIV infection through use of combination antiretrovirals taken prior to risk exposure. With approval of tenofovir/emtricitabine (TDF/FTC) for use as PrEP only in early 2016, and with limited public funding to date, uptake in Canada is in its preliminary stages...
December 7, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29767638/pre-exposure-prophylaxis-with-tenofovir-disoproxil-fumarate-emtricitabine-and-kidney-tubular-dysfunction-in-hiv-uninfected-individuals
#3
Vasantha Jotwani, Rebecca Scherzer, David V Glidden, Megha Mehrotra, Patricia Defechereux, Albert Liu, Monica Gandhi, Michael Bennett, Steven G Coca, Chirag R Parikh, Robert M Grant, Michael G Shlipak
BACKGROUND: Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) is becoming increasingly adopted for HIV prevention. Tenofovir can cause proximal tubular damage and chronic kidney disease in HIV-infected persons, but little is known regarding its nephrotoxic potential among HIV-uninfected persons. In this study, we evaluated the effects of PrEP on urine levels of the following: α1-microglobulin (α1m), a marker of impaired tubular reabsorption; albuminuria, a measure of glomerular injury; and total proteinuria...
June 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29767324/an-empiric-risk-score-to-guide-prep-targeting-among-msm-in-coastal-kenya
#4
Elizabeth Wahome, Alexander N Thiong'o, Grace Mwashigadi, Oscar Chirro, Khamisi Mohamed, Evans Gichuru, John Mwambi, Matt A Price, Susan M Graham, Eduard J Sanders
Men who have sex with men (MSM), who have heterogeneous HIV-acquisition risks are not specifically targeted in Kenyan pre-exposure prophylaxis (PrEP) guidelines. We used data from an open cohort, which followed 753 initially HIV-negative MSM participants for more than 1378.5 person-years, to develop an empiric risk score for targeting PrEP delivery. Independent predictors of incident HIV-1 infection in this cohort were an age of 18-24 years, having only male sex partners, having receptive anal intercourse, having any unprotected sex, and having group sex...
May 16, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29762175/pregnancy-outcomes-and-infant-growth-among-babies-with-in-utero-exposure-to-tenofovir-based-pre-exposure-prophylaxis-for-hiv-prevention
#5
Renee Heffron, Nelly Mugo, Ting Hong, Connie Celum, Mark A Marzinke, Kenneth Ngure, Stephen Asiimwe, Elly Katabira, Elizabeth Bukusi, Josephine Odoyo, Edna Tindimwebwa, Nulu Bulya, Jared M Baeten
BACKGROUND: Global guidelines recommend pre-exposure prophylaxis (PrEP) use by women at risk for HIV, including during pregnancy, a period with heightened HIV risk. However, data to support safety of PrEP use during pregnancy are limited, particularly from women using PrEP throughout pregnancy. METHODS: In an open-label delivery study of PrEP integrated with ART for high risk HIV serodiscordant couples in Kenya and Uganda (the Partners Demonstration Project), women who became pregnant while using PrEP were offered the option to continue PrEP throughout pregnancy...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29762169/change-in-sexual-risk-behaviour-after-six-months-of-pre-exposure-prophylaxis-use-results-from-the-amsterdam-prep-demonstration-project
#6
Elske Hoornenborg, Liza Coyer, Anna van Laarhoven, Roel Achterbergh, Henry de Vries, Maria Prins, Maarten Schim van der Loeff
OBJECTIVE: HIV pre-exposure prophylaxis (PrEP) use may lead to higher STI incidence via behavioral risk compensation. We examined changes in sexual behaviour between baseline and six months after PrEP initiation among men who have sex with men (MSM) and transgender women (TGW). DESIGN: Prospective, open-label demonstration study at a large sexually transmitted infections (STI) clinic in Amsterdam, the Netherlands. METHODS: Participants answered questions about sexual behaviour in the preceding three months, including number of anal sex partners and frequency of anal sex with and without condom by partner type and were tested for STI...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29758064/risk-perception-and-sex-behaviour-in-pregnancy-and-breastfeeding-in-high-hiv-prevalence-settings-programmatic-implications-for-prep-delivery
#7
Dvora Joseph Davey, Elise Farley, Catriona Towriss, Yolanda Gomba, Linda-Gail Bekker, Pamina Gorbach, Steven Shoptaw, Thomas Coates, Landon Myer
HIV acquisition during pregnancy and breastfeeding significantly contributes toward paediatric HIV infection; however, little is known about risk behaviours in HIV-uninfected pregnant and postpartum women. We conducted twenty-six in-depth-interviews between July and December 2016 using a semi-structured interview guide among HIV-uninfected pregnant and recently postpartum women at-risk of HIV acquisition (defined as reporting ≥1 of the following: partner's serostatus unknown or HIV-infected, recent condomless sex in pregnancy, and/or alcohol use during pregnancy) who attended primary healthcare services...
2018: PloS One
https://www.readbyqxmd.com/read/29754268/the-role-of-social-relationships-in-prep-uptake-and-use-among-transgender-women-and-men-who-have-sex-with-men
#8
Megha L Mehrotra, K Rivet Amico, Vanessa McMahan, David V Glidden, Patricia Defechereux, Juan V Guanira, Robert M Grant
Qualitative studies suggest that social relationships play an important role in HIV pre-exposure prophylaxis (PrEP) use, but there have been few quantitative assessments of the role of social relationships in PrEP uptake or adherence. We examined the association between disclosure of study participation or LGBT identity and PrEP use in the 1603 HIV-negative participants enrolled in the iPrEx OLE study. We also evaluated the association between LGBT social group involvement and PrEP use. Study participation disclosure to parents and LGBT identity disclosure to anyone in a participant's social network were associated with greater PrEP uptake...
May 12, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29745290/healthcare-providers-understanding-of-hiv-serodiscordance-in-south-africa-and-uganda-implications-for-hiv-prevention-in-sub-saharan-africa
#9
Ross Greener, Cecilia Milford, Francis Bajunirwe, Faith N Mosery, Claudia K Ng, Rachel Rifkin, Jasmine Kastner, Lavanya Pillay, Angela Kaida, David R Bangsberg, Jennifer A Smit, Lynn T Matthews
HIV transmission within stable heterosexual HIV serodiscordant couples accounts for almost half the new incident infections in South Africa and Uganda. Advances in HIV prevention provide opportunities to reduce transmission risk within serodiscordant partnerships (e.g., antiretroviral treatment (ART), pre-exposure prophylaxis (PrEP), medical male circumcision, and couples-based HIV counselling and testing). These interventions require a clinical encounter with a provider who recognises prevention opportunities within these partnerships...
May 10, 2018: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29744767/poppers-and-prep-use-of-pre-exposure-prophylaxis-among-men-who-have-sex-with-men-who-use-inhaled-nitrites
#10
H Rhodes Hambrick, Su Hyun Park, John A Schneider, Kenneth H Mayer, Adam W Carrico, Scott E Sherman, Dustin T Duncan
Men who have sex with men (MSM) commonly use inhaled nitrites, or poppers, though their use is a risk factor HIV seroconversion. Pre-exposure prophylaxis, or PrEP, is effective for HIV prevention, but is not widely used, and little is known regarding PrEP use and acceptability among MSM who use inhaled nitrites. We surveyed 580 MSM in Paris, France in 2016 about popper use, sexual behaviors including condomless anal intercourse (CAI), serosorting, and sexual positioning, PrEP use, PrEP candidacy, and interest in alternate PrEP delivery modalities...
May 9, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29741665/evaluation-of-prep-eligibility-criteria-using-sexually-transmissible-infections-as-hiv-risk-markers-at-enrolment-in-prepx-a-large-australian-hiv-pre-exposure-prophylaxis-trial
#11
Vincent J Cornelisse, Christopher K Fairley, Mark Stoove, Jason Asselin, Eric P F Chow, Brian Price, Norman J Roth, Jeff Willcox, B K Tee, Matthew Penn, Christina C Chang, Judith Armishaw, George Forgan-Smith, Edwina J Wright
Background: The PrEPX trial provided HIV pre-exposure prophylaxis (PrEP) to 2600 people in Victoria, Australia. To determine participants' HIV risk, PrEPX used six eligibility criteria derived from the Australian PrEP guidelines, based on the CDC PrEP guidelines. Participants who fulfilled no eligibility criteria could be enrolled if clinically assessed to need PrEP. This study evaluated whether PREPX eligibility criteria correlated with biological HIV risk markers, namely syphilis, anorectal chlamydia or anorectal gonorrhoea (STIs)...
May 7, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29741594/early-adopters-of-hiv-preexposure-prophylaxis-in-a-population-based-combination-prevention-study-in-rural-kenya-and-uganda
#12
Catherine A Koss, James Ayieko, Florence Mwangwa, Asiphas Owaraganise, Dalsone Kwarisiima, Laura B Balzer, Albert Plenty, Norton Sang, Jane Kabami, Theodore D Ruel, Douglas Black, Carol S Camlin, Craig R Cohen, Elizabeth A Bukusi, Tamara D Clark, Edwin D Charlebois, Maya L Petersen, Moses R Kamya, Diane V Havlir
Background: Global guidelines recommend preexposure prophylaxis (PrEP) for individuals with substantial HIV risk. Data on PrEP uptake in sub-Saharan Africa outside of clinical trials are limited. We report on "early adopters" of PrEP in SEARCH, an ongoing population-based study in rural Uganda and Kenya. Methods: Following community mobilization and education on PrEP, population-based HIV testing was conducted. HIV-uninfected adults were offered PrEP based on an empirically-derived HIV risk score or an individual's self-identified HIV risk (if not identified by score)...
May 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29736816/pre-exposure-prophylaxis-for-hiv-infection-in-the-older-patient-what-can-be-recommended
#13
Iacopo Franconi, Giovanni Guaraldi
Over the past 15 years, a significant increase in new HIV/AIDS diagnoses has been observed in the elderly population. This new epidemiological shift has been attributed to a longer sex life, lifestyle and changes in sexual behavior, poor sexual health education, and misconceptions about the absence of sexually transmitted disease in later life. Although many biomedical and behavioral interventions have proven useful to prevent sexually transmitted infections and HIV, pre-exposure prophylaxis (PrEP) has been shown to be the most successful biomedical intervention to prevent HIV in high-risk individuals...
May 8, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29732896/weighing-the-evidence-of-efficacy-of-oral-prep-for-hiv-prevention-in-women-in-southern-africa
#14
Holly Janes, Lawrence Corey, Gita Ramjee, Lindsay N Carpp, Carl Lombard, Myron S Cohen, Peter B Gilbert, Glenda E Gray
As oral tenofovir-based regimens for pre-exposure prophylaxis (PrEP) are adopted as standard of care for HIV prevention, their utilization in clinical trials among women in southern Africa will require an accurate estimate of oral PrEP efficacy in this population. This information is critical for women in choosing this prevention strategy, and in public health policy making. Estimates of the efficacy of oral pre-exposure prophylaxis (PrEP) regimens containing tenofovir have varied widely across trials that enrolled women, with some studies reporting high efficacy and others reporting no efficacy...
May 6, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29728949/threefold-increase-in-prep-uptake-over-time-with-high-adherence-among-young-men-who-have-sex-with-men-in-chicago
#15
Ethan Morgan, Kevin Moran, Daniel T Ryan, Brian Mustanski, Michael E Newcomb
The goal of this work is to better understand utilization and uptake of pre-exposure prophylaxis (PrEP) among young men who have sex with men (YMSM) and transgender women (TGW). We assessed trends and correlates of PrEP use and adherence across three time points of longitudinal data collection among 885 YMSM and TGW (aged 16-29) from the RADAR cohort in Chicago, 2015-2017. Past 6-month PrEP use increased across three visits: from 6.6 to 17.5%. In multivariable models, past 6-month PrEP use was significantly associated with participation in condomless sex, having more sexual partners, and older age...
May 4, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29727292/croi-2018-epidemic-trends-and-advances-in-hiv-prevention
#16
Susan P Buchbinder, Albert Y Liu
At the 2018 Conference on Retroviruses and Opportunistic Infections, trends in and risk factors for in HIV infection were highlighted. In the United States, new HIV diagnoses are highest in the South and among African Americans and are increasing in rural areas. Youth remain highly vulnerable to HIV infection globally. The epidemiology of HIV infections among people who inject drugs is changing, with overdose deaths, a major public health concern. Phylogenetics are being used to identify HIV transmission clusters and hotspots, which can inform prevention efforts...
May 2018: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/29725192/african-american-clergy-perspectives-about-the-hiv-care-continuum-results-from-a-qualitative-study-in-jackson-mississippi
#17
Amy Nunn, Sharon Parker, Katryna McCoy, Mauda Monger, Melverta Bender, Joanna Poceta, Julia Harvey, Gladys Thomas, Kendra Johnson, Yusuf Ransome, Cassandra Sutten Coats, Phil Chan, Leandro Mena
Mississippi has some of the most pronounced racial disparities in HIV infection in the country; African Americans comprised 37% of the Mississippi population but represented 80% of new HIV cases in 2015. Improving outcomes along the HIV care continuum, including linking and retaining more individuals and enhancing adherence to medication, may reduce the disparities faced by African Americans in Mississippi. Little is understood about clergy's views about the HIV care continuum. We assessed knowledge of African American pastors and ministers in Jackson, Mississippi about HIV and the HIV care continuum...
2018: Ethnicity & Disease
https://www.readbyqxmd.com/read/29714824/physiologically-based-pharmacokinetic-model-of-vaginally-administered-dapivirine-ring-and-film-formulations
#18
Katherine Kay, Dhaval K Shah, Lisa Rohan, Robert Bies
AIMS: A physiologically-based pharmacokinetic (PBPK) model of the vaginal space was developed with the aim of predicting concentrations in the vaginal and cervical space. These predictions can be used to optimize the probability of success of vaginally administered dapivirine (DPV) for HIV prevention. We focus on vaginal delivery using either a ring [1] or film [2]. METHODS: A PBPK model describing the physiological structure of the vaginal tissue and fluid was defined mathematically and implemented in MATLAB...
May 1, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29713838/acceptability-of-antiretroviral-pre-exposure-prophylaxis-from-a-cohort-of-sexually-experienced-young-transgender-women-in-two-u-s-cities
#19
Arjee J Restar, Lisa Kuhns, Sari L Reisner, Adedotun Ogunbajo, Robert Garofalo, Matthew J Mimiaga
Emtricitabine/tenofovir disoproxil fumarate as pre-exposure prophylaxis (PrEP) can prevent HIV infection among at-risk individuals, including young transgender women (YTW). We used baseline data from 230 HIV-uninfected YTW (ages 16-29 years) who were enrolled in Project LifeSkills during 2012-2015. We examined factors associated with perceived acceptability of PrEP use (mean score = 23.4, range 10.0-30.0). Participants were largely transgender women of color (67%) and had a mean age of 23 years (SD = 3...
April 30, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29702659/provider-perspectives-on-prep-for-adolescent-girls-and-young-women-in-tanzania-the-role-of-provider-biases-and-quality-of-care
#20
Nanlesta Pilgrim, Nrupa Jani, Sanyukta Mathur, Catherine Kahabuka, Vaibhav Saria, Neema Makyao, Lou Apicella, Julie Pulerwitz
BACKGROUND: Oral pre-exposure prophylaxis (PrEP) has the potential to reduce HIV acquisition among adolescent girls and young women (AGYW) in sub-Saharan Africa. However, health care providers' (HCPs) perspectives and interactions with potential clients can substantially influence effective provision of quality health services. We examine if HCPs' knowledge, attitude, and skills, as well as their perceptions of facility readiness to provide PrEP are associated with their willingness to provide PrEP to AGYW at high risk of HIV in Tanzania...
2018: PloS One
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