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https://www.readbyqxmd.com/read/29334549/cost-effectiveness-of-alternative-strategies-for-provision-of-hiv-pre-exposure-prophylaxis-for-people-who-inject-drugs
#1
Rui Fu, Douglas K Owens, Margaret L Brandeau
BACKGROUND: Oral HIV pre-exposure prophylaxis (PrEP) has been recommended as a means of HIV prevention among people who inject drugs (PWID) but, at current prices, is unlikely to be cost-effective for all PWID. OBJECTIVE: To determine the cost-effectiveness of alternative strategies for enrolling PWID in PrEP. DESIGN: Dynamic network model that captures HIV transmission and progression among PWID in a representative US urban center. OUTCOME MEASURES: HIV infections averted, discounted costs and quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs)...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334545/bacterial-vaginosis-modifies-the-association-between-hormonal-contraception-and-hiv-acquisition
#2
Lisa Haddad, Kristin M Wall, William Kilembe, Bellington Vwailika, Naw Htee, Ilene Brill, Elwyn Chomba, Amanda Tichacek, Susan Allen
OBJECTIVE: To examine BV as an effect modifier for the association between hormonal contraception (HC) and incident HIV infection DESIGN:: Serodiscordant couples enrolled in an open longitudinal cohort in Lusaka, Zambia from 1994-2012. This analysis was restricted to couples with an HIV-positive man enrolled between1994-2002 when a quarterly genital tract examination and HIV testing was performed. METHODS: Multivariate Cox models evaluated the association between contraceptive method and HIV-acquisition, stratified by time-varying BV status...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334178/factors-associated-with-perceived-accuracy-of-the-undetectable%C3%A2-%C3%A2-untransmittable-slogan-among-men-who-have-sex-with-men-implications-for-messaging-scale-up-and-implementation
#3
H Jonathon Rendina, Jeffrey T Parsons
INTRODUCTION: Recent research has shown high efficacy of HIV treatment for reducing the risk of HIV transmission to sexual partners. As the efficacy of treatment as prevention (TasP) has proliferated, a new messaging campaign, Undetectable = Untransmittable, has been gaining popularity. The purpose of this paper was to assess factors associated with the perceived accuracy of this TasP messaging strategy among a large and diverse sample of gay, bisexual, and other men who have sex with men (GBMSM) in order to inform subsequent efforts at large-scale and implementation of the HIV prevention message...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29327091/temporal-fluctuations-in-behavior-perceived-hiv-risk-and-willingness-to-use-pre-exposure-prophylaxis-prep
#4
Kristen Underhill, Kate M Guthrie, Christopher Colleran, Sarah K Calabrese, Don Operario, Kenneth H Mayer
Individual perceptions of HIV risk influence willingness to use pre-exposure prophylaxis (PrEP) for HIV prevention. Among men who have sex with men (MSM) and male sex workers (MSWs), temporal or episodic changes in risk behavior may influence perceived risk and PrEP acceptability over time. We investigated fluctuations in perceived HIV risk and PrEP acceptability, comparing MSWs against MSM who do not engage in sex work. We conducted 8 focus groups (n = 38) and 56 individual interviews among MSM and MSWs in Providence, RI...
January 11, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29326373/hepatitis-a-infections-in-men-who-have-sex-with-men-using-hiv-prep-in-paris
#5
Pauline Penot, Marie-Alice Colombier, Sarah Maylin, Jean-Michel Molina
The current hepatitis A outbreak in Europe is largely involving men having sex with multiple male partners. The objective of the present report was to warn teams dealing against the persistent risk of viral and bacterial sexually transmitted infection (STIs) in patients receiving HIV pre-exposure prophylaxis (PrEP). We have notified and investigated three cases of acute hepatitis A virus (HAV) infection in people receiving HIV PrEP in our clinic between December 2016 and March 2017. The patients were not epidemiologically related, had no recent travel history to HAV endemic areas, reported multiple STIs during this period and had not been vaccinated against HAV...
January 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29324178/sex-venue-based-network-analysis-to-identify-hiv-prevention-dissemination-targets-for-men-who-have-sex-with-men
#6
Rupa R Patel, Douglas A Luke, Enola K Proctor, William G Powderly, Philip A Chan, Kenneth H Mayer, Laura C Harrison, Amar Dhand
PURPOSE: The aim of this study was to identify sex venue-based networks among men who have sex with men (MSM) to inform HIV preexposure prophylaxis (PrEP) dissemination efforts. METHODS: Using a cross-sectional design, we interviewed MSM about the venues where their recent sexual partners were found. Venues were organized into network matrices grouped by condom use and race. We examined network structure, central venues, and network subgroups. RESULTS: Among 49 participants, the median age was 27 years, 49% were Black and 86% reported condomless anal sex (ncAS)...
January 2018: LGBT Health
https://www.readbyqxmd.com/read/29323688/preventing-hiv-infection-what-pediatricians-should-know-about-hiv-pre-exposure-prophylaxis
#7
Sabrina Fernandez
I recently diagnosed my first adolescent patient with new-onset HIV. As a primary care pediatrician, these cases are rare. I cried with the shock of the initial diagnosis, just as the patient did when I told him. One of my first thoughts was how could I have served him better. He had been inconsistent with condom use, and had several partners. I had encouraged safe sex practices, told him to talk to his partners about pregnancy prevention, and screened for sexually transmitted disease nearly every time he came into my office...
January 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29323558/optimizing-delivery-of-hiv-preexposure-prophylaxis-for-women-in-the-united-states
#8
Erika Aaron, Cori Blum, Dominika Seidman, Mary Jo Hoyt, Joanne Simone, Meg Sullivan, Dawn K Smith
Preexposure prophylaxis (PrEP) is a highly effective HIV prevention method; however, it is underutilized among women who are at risk for acquisition of HIV. Women comprise one in five HIV diagnoses in the United States, and significant racial disparities in new HIV diagnoses persist. The rate of new HIV diagnoses among black and African American women in 2015 was 16 times greater than that of white women. These disparities highlight the importance of HIV prevention strategies for women, including the use of PrEP...
January 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29297377/ethical-considerations-in-developing-an-evidence-base-for-pre-exposure-prophylaxis-in-pregnant-women
#9
Kristen A Sullivan, Anne D Lyerly
Though many women in need of access to HIV preventive regimes are pregnant, there is a dearth of data to guide these care decisions. While oral pre-exposure prophylaxis (PrEP) has been shown to prevent HIV infection in numerous high-risk populations, pregnant women have been excluded from all major prospective trials. We propose for ethical examination a theoretical trial-a prospective, observational study of PrEP for pregnant women at risk for HIV in sub-Saharan Africa-highlighting an ethical tradeoff that characterizes issues faced for advancing research in pregnancy...
December 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29297375/the-role-of-male-partners-in-women-s-participation-in-research-during-pregnancy-a-case-study-from-the-partners-demonstration-project
#10
Kenneth Ngure, Susan Brown Trinidad, Kristin Beima-Sofie, Jared M Baeten, Nelly R Mugo, Elizabeth A Bukusi, Renee Heffron, Grace John-Stewart, Maureen C Kelley
The exclusion of pregnant women from health research remains a significant challenge globally. In settings where cultural traditions and gender norms support a more restricted decision-making role for women in general, little is known about the attitudes of male partners toward the inclusion of women in research during pregnancy. Understanding the expectations of both men and women in such cultural settings offers an opportunity to engage and address local ethical concerns to improve women's access to research during pregnancy and enhance intervention development...
December 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29290075/expanding-the-menu-of-hiv-prevention-options-a-qualitative-study-of-experiences-with-long-acting-injectable-cabotegravir-as-prep-in-the-context-of-a-phase-ii-trial-in-the-united-states
#11
D Kerrigan, A Mantsios, R Grant, M Markowitz, P Defechereux, M La Mar, S W Beckham, P Hammond, D Margolis, M Murray
Adherence challenges with oral pre-exposure prophylaxis have stimulated interest in alternate modes of administration including long-acting injections. We conducted 30 in-depth interviews with 26 male trial participants and 4 clinical providers in a Phase IIa study (ÉCLAIR) evaluating the use of long-acting cabotegravir (CAB-LA) injections in New York and San Francisco. Interviews exploring attitudes and experiences with CAB-LA were audiotaped, transcribed, and analyzed using thematic content analysis. Despite a high frequency of some level of side effects, almost all participants reported being interested in continuing with CAB-LA, versus a daily oral, due to its convenience and the perceived advantage of not worrying about adhering to pills...
December 30, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29285638/the-use-of-online-posts-to-identify-barriers-to-and-facilitators-of-hiv-pre-exposure-prophylaxis-prep-among-men-who-have-sex-with-men-a-comparison-to-a-systematic-review-of-the-peer-reviewed-literature
#12
Alisse Hannaford, Madeleine Lipshie-Williams, Joanna L Starrels, Julia H Arnsten, Jessica Rizzuto, Phillip Cohen, Damon Jacobs, Viraj V Patel
Pre-exposure prophylaxis (PrEP) remains an under-utilized HIV prevention tool among men who have sex with men (MSM). To more comprehensively elucidate barriers and facilitators to PrEP use among US MSM, we conducted a systematic review of peer-reviewed published articles and content analysis of online posts about PrEP. We searched peer-reviewed databases (Medline, Web of Science, Google Scholar) using MESH headings and keywords about PrEP and/or HIV prevention from 2005 to 2015. We included original studies among MSM in the US that reported on barriers, facilitators, or other factors related to PrEP use...
December 28, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29281688/home-based-pre-exposure-prophylaxis-prep-services-for-gay-and-bisexual-men-an-opportunity-to-address-barriers-to-prep-uptake-and-persistence
#13
Steven A John, H Jonathon Rendina, Christian Grov, Jeffrey T Parsons
Gay, bisexual, and other men who have sex with men (GBM) are disproportionately affected by the HIV epidemic. Despite the promise of pre-exposure prophylaxis (PrEP) in reducing HIV transmission risk, barriers for uptake and persistence exist. We sought to identify whether GBM in a nationwide cohort who have not yet initiated PrEP (n = 906) would prefer to get PrEP-related care from a primary care provider (PCP) compared to a specialist clinic or provider. We then sought to identify their level of interest and factors associated with preference for using home-based PrEP services (i...
2017: PloS One
https://www.readbyqxmd.com/read/29280797/a-missed-opportunity-in-hiv-prevention
#14
Sibyl Wilmont
PrEP is effective in at-risk individuals, but barriers to widespread use remain.
January 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29280768/hiv-pre-exposure-prophylaxis-prep-prescribing-through-telehealth
#15
Joanne D Stekler, Vanessa Mcmahan, Lark Ballinger, Luis Viquez, Fred Swanson, Jon Stockton, Beth Crutsinger-Perry, David Kern, John D Scott
No abstract text is available yet for this article.
December 26, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29278971/prevention-strategies-against-hiv-transmission-a-proactive-approach
#16
Antonio J Carrion, Jovan D Miles, Juan F Mosley, Lillian L Smith, April S Prather, Marcus M Gurley, Linh D Phan, Emily C Everton
Human immunodeficiency virus (HIV) has now transformed into a manageable chronic condition. Highly active antiretroviral therapy (HAART) has proven efficacious at controlling the disease progression. Based on compelling evidence, the Department of Health and Human Services (DHHS) and the Infectious Disease Society of America (IDSA) developed guidelines for the management of persons infected with HIV. However, there are approximately 50 000 new cases of HIV in the United States each year. In this article, we review proactive methods to reduce the transmission of HIV, which include reinforcing patient education, gel-coated condoms that destroy HIV, HIV vaccinations, and adequately utilizing pre-exposure prophylaxis (PrEP), and post-exposure prophylaxis (PEP)...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278542/potential-kidney-toxicity-from-the-antiviral-drug-tenofovir-new-indications-new-formulations-and-a-new-prodrug
#17
Lili Chan, Benjamin Asriel, Ellen F Eaton, Christina M Wyatt
PURPOSE OF REVIEW: The antiviral agent tenofovir is highly effective for the treatment of HIV and hepatitis B virus infections, and the older prodrug tenofovir disoproxil fumarate (TDF) is also a component of daily preexposure prophylaxis (PrEP) to reduce the risk of HIV infection in high-risk populations. Although TDF is well tolerated, the potential for kidney and bone toxicity has important implications for public health given the large number of individuals exposed to TDF worldwide...
December 22, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29274655/do-you-prep-a-review-of-primary-care-provider-knowledge-of-prep-and-attitudes-on-prescribing-prep
#18
Leah Turner, Abbey Roepke, Emily Wardell, Anne M Teitelman
Oral preexposure prophylaxis (PrEP) has been proven to be a safe and effective means of preventing HIV. The purpose of our literature review was to examine primary care provider knowledge and attitudes about prescribing PrEP. PubMed, CINAHL, Web of Science, and Scopus were searched and additional articles were identified through other sources, yielding 11 articles that met inclusion criteria. Overall, there was high variability among providers regarding attitudes, knowledge, and prescriptive practices related to PrEP...
January 2018: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/29248392/targeting-human-immunodeficiency-virus-pre-exposure-prophylaxis-to-adolescent-sexual-minority-males-in-higher-prevalence-areas-of-the-united-states-a-modeling-study
#19
Steven M Goodreau, Deven T Hamilton, Samuel M Jenness, Patrick S Sullivan, Rachel K Valencia, Li Yan Wang, Richard L Dunville, Lisa C Barrios, Eli S Rosenberg
PURPOSE: Pre-exposure prophylaxis (PrEP) is an effective and safe intervention to prevent human immunodeficiency virus (HIV) transmission in men who have sex with men; current Centers for Disease Control and Prevention guidelines indicate its use among high-risk adults. Adolescent sexual minority males (ASMM) also have significant HIV risk, but implementation strategies are likely to differ for this population. We aimed to estimate impact and efficiency of PrEP for ASMM in higher prevalence US settings, using a variety of implementation strategies and assumptions about coverage, adherence, and background prevalence...
December 13, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29243109/hiv-pre-exposure-prophylaxis-prep-uptake-and-retention-among-men-who-have-sex-with-men-in-a-community-based-sexual-health-clinic
#20
J Carlo Hojilla, David Vlahov, Pierre-Cedric Crouch, Carol Dawson-Rose, Kellie Freeborn, Adam Carrico
In a community-based clinic serving men who have sex with men in San Francisco, California, this study characterized key steps of the pre-exposure prophylaxis (PrEP) cascade and identified correlates of retention in care. In total, 344 patients were evaluated for PrEP. Three-fourths (78%) of those who sought PrEP services initiated PrEP. The overall cumulative incidence of discontinuing PrEP at 13 months was 38%. Men with a sexually transmitted infection (STI) were 44% less likely to be retained (adjusted hazard ratio [aHR] 0...
December 14, 2017: AIDS and Behavior
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