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https://www.readbyqxmd.com/read/28791876/limited-awareness-of-pre-exposure-prophylaxis-among-black-men-who-have-sex-with-men-and-transgender-women-in-new%C3%A2-york-city
#1
Matthew Garnett, Yael Hirsch-Moverman, Julie Franks, Eleanor Hayes-Larson, Wafaa M El-Sadr, Sharon Mannheimer
Awareness of Pre-exposure prophylaxis (PrEP) was assessed among a cohort of substance-using black men who have sex with men and transgender women (MSM/TGW) participating in the STAR Study, which recruited black MSM/TGW in New York City for HIV testing and linked HIV-infected individuals into care from July 2012 to April 2015. Sociodemographic, psychosocial, known HIV risk factors, and PrEP awareness were assessed among participants. Multivariable logistic regression was conducted to assess factors associated with PrEP awareness...
August 9, 2017: AIDS Care
https://www.readbyqxmd.com/read/28782336/willingness-to-use-pre-exposure-prophylaxis-prep-for-hiv-prevention-among-men-who-have-sex-with-men-msm-in-malaysia-findings-from-a-qualitative-study
#2
Adam Bourne, Matteo Cassolato, Clayton Koh Thuan Wei, Bangyuan Wang, Joselyn Pang, Sin How Lim, Iskandar Azwa, Ilias Yee, Gitau Mburu
BACKGROUND: Men who have sex with men (MSM) continue to be disproportionately affected by HIV in Malaysia. Recent success has been observed within demonstration projects examining the efficacy of HIV pre-exposure prophylaxis (PrEP), an antiretroviral -based medication taken by HIV-negative men to prevent sero-conversion. In order for such promising findings to be translated in real-world settings, it is important to understand the acceptability of PrEP, including perceived barriers to access or uptake...
August 2, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28780885/perspectives-on-biomedical-hiv-prevention-options-among-women-who-inject-drugs-in-kenya
#3
Angela Robertson Bazzi, Kelly A Yotebieng, Kawango Agot, Grace Rota, Jennifer L Syvertsen
Due to heightened vulnerability to HIV from frequent engagement in sex work and overlapping drug-using and sexual networks, women who inject drugs should be a high priority population for pre-exposure prophylaxis (PrEP) and other biomedical HIV prevention tools. Kenya is one of the first African countries to approve oral PrEP for HIV prevention among "key populations," including people who inject drugs and sex workers. The objective of this study was to explore preferences and perceived challenges to PrEP adoption among women who inject drugs in Kisumu, Kenya...
August 5, 2017: AIDS Care
https://www.readbyqxmd.com/read/28777265/-i-did-not-want-to-give-birth-to-a-child-who-has-hiv-experiences-using-prep-during-pregnancy-among-hiv-uninfected-kenyan-women-in-hiv-serodiscordant-couples
#4
Jillian Pintye, Kristin M Beima-Sofie, Grace Kimemia, Kenneth Ngure, Susan Brown Trinidad, Renee Heffron, Jared Baeten, Josephine Odoyo, Nelly Mugo, Elizabeth A Bukusi, Maureen C Kelley, Grace C John-Stewart
OBJECTIVES: The perceptions, motivations, and beliefs of HIV-uninfected women about PrEP use during pregnancy can influence its uptake and adherence. This study elicited the views of HIV-uninfected women with personal experience taking PrEP during pregnancy. DESIGN: Qualitative interviews were conducted with HIV-uninfected women who had personal experience taking PrEP while pregnant. METHODS: Semi-structured interviews were conducted with 21 HIV-uninfected Kenyan women in HIV-serodiscordant couples enrolled in an open-label PrEP demonstration project who became pregnant while using PrEP and continued PrEP through their pregnancy...
July 31, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28777264/feasibility-acceptability-and-adherence-with-short-term-hiv-pre-exposure-prophylaxis-in-female-sexual-partners-of-migrant-miners-in-mozambique
#5
Maria Lahuerta, Allison Zerbe, Rachel Baggaley, Joana Falcao, Laurence Ahoua, Pietro DiMattei, Fernando Morales, Isaias Ramiro, Wafaa M El-Sadr
BACKGROUND: Pre-exposure prophylaxis (PrEP) offers protection from HIV acquisition if taken as prescribed. We evaluated the feasibility, acceptability and adherence with short-term PrEP among female sexual partners of migrant miners in Mozambique. METHODS: HIV-negative female sexual partners of migrant miners were offered daily tenofovir/emtricitabine (TDF/FTC) for 6 weeks concurrent with miners' return home. Study visits occurred at baseline, Week 4, 6 and 8. Dried blood spots (DBS) were collected at Week 4 and 6...
August 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28771856/does-pre-exposure-prophylaxis-prep-for-hiv-prevention-in-men-who-have-sex-with-men-msm-change-risk-behavior-a-systematic-review
#6
REVIEW
Kellie Freeborn, Carmen J Portillo
BACKGROUND: Pre-exposure prophylaxis (PrEP) for HIV has been available since 2012. Even so, PrEP has not been widely accepted among healthcare providers and MSM some of whom are convinced that PrEP decreases condom use, and increases sexually transmitted infections (STIs). DESIGN: A systematic review of the state of the evidence regarding the association of PrEP with condom use, STI incidence and change in sexual risk behaviors in MSM. A structured search of databases resulted in 142 potential citations, but only ten publications met inclusion criteria and underwent data abstraction and critical appraisal...
August 3, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28771076/demand-for-pre-exposure-prophylaxis-for-hiv-and-the-impact-on-clinical-services-scottish-men-who-have-sex-with-men-perspectives
#7
R I Gilson, D J Clutterbuck, Z E Chen
There is a lack of data on ability and willingness of men who have sex with men (MSM) to self-fund HIV pre-exposure prophylaxis (PrEP). We aimed to explore how many eligible (PROUD study criteria) men may want PrEP and how many lower-risk MSM would be willing and able to self-fund this intervention. A self-completed anonymous questionnaire was distributed to MSM populations attending services. Of 377 participants, 81.5% were aware of PrEP. Fifty-three (15.5 %) were eligible, of whom 43 (81%) were very/extremely likely to want it...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28758027/australasian-society-for-hiv-viral-hepatitis-and-sexual-health-medicine-hiv-pre-exposure-prophylaxis-clinical-guidelines
#8
EDITORIAL
Edwina Wright, Andrew Grulich, Katy Roy, Mark Boyd, Vincent Cornelisse, Darren Russell, Darryl O'Donnell, Bill Whittaker, Levinia Crooks, Iryna Zablotska
Daily use of coformulated tenofovir and emtricitabine for HIV pre-exposure prophylaxis (PrEP) by populations at high risk of HIV infection is now recommended in guidelines from the United States, Europe and Australia and globally through the 2015 WHO guidelines. These 2017 Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine's (ASHM) PrEP Guidelines are an updated adaptation of the 2014 US Centers for Disease Control's PrEP guidelines and are designed to: •Support the prescription of PrEP using forms of coformulated tenofovir and emtricitabine that have been registered in Australia by the Therapeutic Goods Administration and other bioequivalent generic drugs that are available in Australia through self-importation, private prescription or Australian PrEP clinical trials•Assist clinicians in the evaluation of patients who are seeking PrEP•Assist clinicians in commencing and monitoring patients on PrEP including PrEP dosing schedules, management of side-effects and toxicity, use of PrEP in pregnancy and in chronic hepatitis B infection and how to cease PrEP Daily PrEP with co-formulated tenofovir and emtricitabine, used continuously or for shorter periods of time, is recommended in these guidelines as a key HIV-prevention option for men who have sex with men (MSM), transgender men and women, heterosexual men and women, and people who inject drugs (PWID) at substantial risk of HIV acquisition...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28756409/female-and-younger-subjects-have-lower-adherence-in-prep-trials-a-meta-analysis-with-implications-for-the-uptake-of-prep-service-to-prevent-hiv
#9
REVIEW
Ke Yun, Jun-Jie Xu, Jing Zhang, Jia-Ming Li, Qing-Hai Hu, Zhen-Xing Chu, Yong-Jun Jiang, Wen-Qing Geng, Hong Shang, Ning Wang
OBJECTIVE: To estimate the medicine-taking compliance (MTC) level, explore its facilitators and barriers, and quantify the association between MTC level and pre-exposure prophylaxis (PrEP) protective efficacy in individuals at risk of acquiring HIV being administered oral PrEP. DESIGN: Meta-analysis. DATA SOURCES: We searched PubMed, Cochrane and Embase databases for published randomized controlled trials (RCTs) pertaining to MTC of oral PrEP for HIV prevention up to 16 January 2017...
July 29, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28752354/acceptability-of-daily-use-of-free-oral-pre-exposure-prophylaxis-prep-among-transgender-women-sex-workers-in-shenyang-china
#10
Zixin Wang, Joseph T F Lau, Xueying Yang, Yong Cai, Danielle L Gross, Tiecheng Ma, Yan Liu
This study investigated the acceptability of daily use of free oral pre-exposure prophylaxis (PrEP) and associated factors among transgender women sex workers in Shenyang, China, following a briefing on PrEP. A total of 183 HIV negative or sero-status unknown participants completed the cross-sectional survey. The prevalence of acceptability of daily use of free oral PrEP was 61.2%. Adjusting for education level and monthly income, variables on negative attitudes toward PrEP (i.e., having concerns about the side-effects of PrEP) [Adjusted odds ratios (AOR): 0...
July 27, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28747302/prep-on-demand-reduces-hiv-infections-study-finds
#11
Sophie Cousins
No abstract text is available yet for this article.
July 26, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28747274/efficacy-safety-and-effect-on-sexual-behaviour-of-on-demand-pre-exposure-prophylaxis-for-hiv-in-men-who-have-sex-with-men-an-observational-cohort-study
#12
Jean-Michel Molina, Isabelle Charreau, Bruno Spire, Laurent Cotte, Julie Chas, Catherine Capitant, Cecile Tremblay, Daniela Rojas-Castro, Eric Cua, Armelle Pasquet, Camille Bernaud, Claire Pintado, Constance Delaugerre, Luis Sagaon-Teyssier, Soizic Le Mestre, Christian Chidiac, Gilles Pialoux, Diane Ponscarme, Julien Fonsart, David Thompson, Mark A Wainberg, Veronique Doré, Laurence Meyer
BACKGROUND: Data for on-demand pre-exposure prophylaxis (PrEP) are scarce. We implemented a cohort study to assess its efficacy, safety, and effect on sexual behaviour. METHODS: We invited men and transgender women who have sex with men, previously enrolled in the randomised placebo-controlled ANRS IPERGAY trial at seven sites (six in France and one in Canada), to participate in an open-label extension with on-demand tenofovir disoproxil fumarate (300 mg) and emtricitabine (200 mg) to be taken before and after sexual intercourse...
July 21, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28747167/combined-interventions-to-reduce-hiv-incidence-in-kwazulu-natal-a-modelling-study
#13
Stéphanie Blaizot, Helena Huerga, Benjamin Riche, Tom Ellman, Amir Shroufi, Jean-François Etard, René Ecochard
BACKGROUND: Combined prevention interventions, including early antiretroviral therapy initiation, may substantially reduce HIV incidence in hyperendemic settings. Our aim was to assess the potential short-term impact of combined interventions on HIV spreading in the adult population of Mbongolwane and Eshowe (KwaZulu-Natal, South Africa) using sex- and age-specific scenarios, and age-targeted interventions. METHODS: A mathematical model was used with data on adults (15-59 years) from the Mbongolwane and Eshowe HIV Impact in Population Survey to compare the effects of various interventions on the HIV incidence rate...
July 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28746164/implementation-of-a-novel-adherence-monitoring-strategy-in-a-phase-iii-blinded-placebo-controlled-hiv-1-prevention-clinical-trial
#14
Marla J Husnik, Elizabeth R Brown, Mark Marzinke, Edward Livant, Thesla Palanee-Phillips, Craig Hendrix, Flavia Matovu Kiweewa, Gonasagrie Nair, Lydia E Soto-Torres, Katie Schwartz, Sharon L Hillier, Jared M Baeten
BACKGROUND: Placebo-controlled HIV-1 prevention trials of pre-exposure prophylaxis (PrEP) have not generally used concurrent measurement of adherence due to the potential risk of unblinding. However, several PrEP trials for HIV-1 prevention among women failed to show effectiveness due to low product adherence. Evaluation of product adherence objectively during a study provides the opportunity for strengthening adherence activities at sites having low adherence. METHODS: During MTN-020/ASPIRE, a phase III, placebo-controlled trial of the dapivirine intravaginal ring, we implemented an adherence monitoring system...
July 24, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28744983/an-evaluation-of-a-clinical-pre-exposure-prophylaxis-education-intervention-among-men-who-have-sex-with-men
#15
Julia Raifman, Amy Nunn, Catherine E Oldenburg, Madeline C Montgomery, Alexi Almonte, Allison L Agwu, Renata Arrington-Sanders, Philip A Chan
OBJECTIVE: To evaluate the impact of an HIV pre-exposure prophylaxis (PrEP) education intervention on PrEP awareness and use among men who have sex with men (MSM) attending a sexually transmitted diseases (STD) clinic. DATA SOURCES/STUDY SETTING: Men who have sex with men STD clinic patients. STUDY DESIGN: We estimated a difference-in-differences linear regression model, comparing MSM whose first visit to the clinic was before ("control") or after ("treatment") intervention implementation and controlling for patient...
July 25, 2017: Health Services Research
https://www.readbyqxmd.com/read/28741332/willingness-to-use-hiv-pre-exposure-prophylaxis-among-gay-men-other-men-who-have-sex-with-men-and-transgender-women-in-myanmar
#16
Bridget L Draper, Zaw Min Oo, Zaw Win Thein, Poe Poe Aung, Vanessa Veronese, Claire Ryan, Myo Thant, Chad Hughes, Mark Stoové
INTRODUCTION: HIV pre-exposure prophylaxis (PrEP) has emerged as a key component of contemporary HIV combination prevention strategies. To explore the local suitability of PrEP, country-specific acceptability studies are needed to inform potential PrEP implementation. In the context of Myanmar, in addition to resource constraints, HIV service access by gay men, other men who have sex with men, and transgender women (GMT) continues to be constrained by legislative and community stigma and marginalization...
July 26, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28741331/alignment-of-adherence-and-risk-for-hiv-acquisition-in-a-demonstration-project-of-pre-exposure-prophylaxis-among-hiv-serodiscordant-couples-in-kenya-and-uganda-a-prospective-analysis-of-prevention-effective-adherence
#17
Jessica E Haberer, Lara Kidoguchi, Renee Heffron, Nelly Mugo, Elizabeth Bukusi, Elly Katabira, Stephen Asiimwe, Katherine K Thomas, Connie Celum, Jared M Baeten
INTRODUCTION: Adherence is essential for pre-exposure prophylaxis (PrEP) to protect against HIV acquisition, but PrEP use need not be life-long. PrEP is most efficient when its use is aligned with periods of risk - a concept termed prevention-effective adherence. The objective of this paper is to describe prevention-effective adherence and predictors of adherence within an open-label delivery project of integrated PrEP and antiretroviral therapy (ART) among HIV serodiscordant couples in Kenya and Uganda (the Partners Demonstration Project)...
July 25, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28732773/efficacy-of-oral-pre-exposure-prophylaxis-prep-for-hiv-among-women-with-abnormal-vaginal-microbiota-a-post-hoc-analysis-of-the-randomised-placebo-controlled-partners-prep-study
#18
Renee Heffron, R Scott McClelland, Jennifer E Balkus, Connie Celum, Craig R Cohen, Nelly Mugo, Elizabeth Bukusi, Deborah Donnell, Jairam Lingappa, James Kiarie, Tina Fiedler, Matthew Munch, David N Fredricks, Jared M Baeten
BACKGROUND: Daily oral tenofovir-based pre-exposure prophylaxis (PrEP) is high efficacious for HIV prevention among women with high adherence. However, the effect of abnormal vaginal microbiota on PrEP efficacy is of concern. We investigated whether bacterial vaginosis modified the efficacy of oral PrEP. METHODS: We used prospectively collected data from women in the Partners PrEP Study, a placebo-controlled trial of daily oral PrEP (either tenofovir monotherapy or a combination of tenofovir and emtricitabine) in HIV serodiscordant couples aged 18 years or older in Kenya and Uganda that showed high efficacy in women...
July 18, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28729879/safety-and-immunogenicity-of-the-quadrivalent-human-papillomavirus-qhpv-vaccine-in-hiv-positive-spanish-men-who-have-sex-with-men-msm
#19
Carmen Hidalgo-Tenorio, Jessica Ramírez-Taboada, Concepción Gil-Anguita, Javier Esquivias, Mohamed Omar-Mohamed-Balgahata, Antonio SamPedro, Miguel Lopez-Ruz, Juan Pasquau
BACKGROUND: Safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccine were evaluated in HIV-positive Spanish MSM. The prevalence of High Squamous Intraepithelial Lesions (HSIL) and genotypes of high-risk human papillomavirus (HR-HPV) were also determined, as well as risk factors associated with the presence of HR-HPV in anal mucosa. METHODS: This is a randomised, double blind, placebo-controlled trial of the quadrivalent HPV (qHPV) vaccine...
2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28729516/high-hiv-incidence-in-men-who-have-sex-with-men-following-an-early-syphilis-diagnosis-is-there-room-for-pre-exposure-prophylaxis-as-a-prevention-strategy
#20
Nicolò Girometti, Angela Gutierrez, Nneka Nwokolo, Alan McOwan, Gary Whitlock
OBJECTIVES: HIV pre-exposure prophylaxis (PrEP) is becoming a pivotal strategy for HIV prevention. Understanding the impact of risk factors for HIV transmission to identify those at highest risk would favour the implementation of PrEP, currently limited by costs. In this service evaluation, we estimated the incidence of bacterial STIs in men who have sex with men (MSM) diagnosed with early syphilis attending a London sexual health clinic according to their HIV status. In addition, we estimated the incidence of HIV infection in HIV-negative MSM, following a diagnosis of early syphilis...
August 2017: Sexually Transmitted Infections
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