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https://www.readbyqxmd.com/read/29759661/integrity-of-the-urethral-sphincter-complex-nerve-sparing-and-long-term-continence-status-after-robotic-assisted-radical-prostatectomy
#1
Myong Kim, Myungchan Park, Sahyun Pak, Seung-Kwon Choi, Myungsun Shim, Cheryn Song, Hanjong Ahn
BACKGROUND: The applicability of the sphincter complex integral theory to robotic-assisted radical prostatectomy (RARP) is unclear, with little known about the long-term effect of sphincter complex integrity on continence. OBJECTIVE: To determine whether the preoperative anatomical and functional features of the sphincter complex and the degree of nerve-sparing affect long-term continence after RARP. DESIGN, SETTING, AND PARTICIPANTS: Prospective study of 529 patients who underwent RARP at a single tertiary center...
May 11, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29722944/-effects-of-different-medications-with-tadalafil-on-erectile-dysfunction-in-males-with-primary-sexual-failure
#2
Wen-Ji Li, Ming-Xi Xu, Jian-Hua Guo, Zhi-Kang Cai, Yue-Qing Jiang, Zhong Wang
Objective: To evaluate the effects of three different medications with tadalafil on erectile dysfunction (ED) in young men with primary sexual failure. METHODS: This study included 76 male ED patients aged 21-35 years who had primary sexual failure but normal nocturnal penile tumescence and rigidity and failed to respond to psychotherapy. We randomly assigned them to receive oral tadalafil once daily, on demand, or once-daily + on-demand. After 2-3 months of treatment, we evaluated the effects based on the scores of the patients in the five domains of the International Index of Erectile Function (IIEF-5)...
June 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29667617/combination-of-stromal-vascular-fraction-and-ad-comp-ang1-gene-therapy-improves-long-term-therapeutic-efficacy-for-diabetes-induced-erectile-dysfunction
#3
Guo-Nan Yin, Lin Wang, Xiang-Nan Lin, Lei Shi, Zhen-Lin Gao, Feng-Chan Han, Ping Li, Yin-Chuan Jin, Jun-Kyu Suh, Ji-Kan Ryu, Xiong Wang, Hai-Rong Jin
Men with diabetic erectile dysfunction (ED) respond poorly to the currently available oral phosphodiesterase-5 inhibitors. Therefore, functional therapies for diabetic ED are needed. Stromal vascular fraction (SVF) and the adenovirus-mediated cartilage oligomeric matrix angiopoietin-1 (Ad-COMP-Ang1) gene are known to play critical roles in penile erection. We previously reported that SVF and Ad-COMP-Ang1 have only a short-term effect in restoring erectile function. Further improvements to ED therapy are needed for long-lasting effects...
April 17, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29574984/endopeptidase-inhibition-attenuates-the-contraction-induced-by-big-endothelin-1-of-isolated-human-penile-erectile-tissue
#4
P Shahin, H E Rahardjo, A Bannowsky, D Tsikas, M Sohn, M A Kuczyk, S Ückert
Peptides, such as C-type natriuretic peptide (CNP), vasoactive intestinal polypeptide (VIP) and endothelin 1 (ET-1), are involved in the control of penile erectile tissue (corpus cavernosum = CC). Inhibiting the degradation of CNP and VIP or conversion of Big ET-1 into ET-1 by endopeptidase enzymes should result in an enhancement of CC smooth muscle relaxation. Using the tissue bath technique, responses of isolated CC, challenged by noradrenaline (NA, 1 μm), to increasing concentrations of the endopeptidase inhibitor KC 12615 (1 nm - 10 μm), CNP and VIP (0...
March 25, 2018: Andrologia
https://www.readbyqxmd.com/read/29573106/the-effect-of-low-intensity-extracorporeal-shock-wave-therapy-in-an-obesity-associated-erectile-dysfunction-rat-model
#5
Yajun Ruan, Jun Zhou, Ning Kang, Amanda B Reed-Maldonado, Arianna Tamaddon, Bohan Wang, Hsun Shuan Wang, Guifang Wang, Lia Banie, Guiting Lin, Jihong Liu, Tom F Lue
OBJECTIVES: To investigate the feasibility of Zucker fatty rats as a model for obesity-associated erectile dysfunction (OAED) research and to determine the effect of low intensity extracorporeal shock wave therapy (Li-ESWT) on penile tissue and function in these rats. MATERIALS AND METHODS: Eight newborn male Zucker Lean (ZL group) rats (ZUC-Leprfa 186) and 16 newborn male Zucker Fatty (ZF) rats (ZUC-Leprfa 185) were injected with 5-ethynyl-2'-deoxyuridine (EdU) at birth to identify and monitor endogenous stem cells...
March 23, 2018: BJU International
https://www.readbyqxmd.com/read/29559443/pericyte-derived-dickkopf2-regenerates-damaged-penile-neurovasculature-through-an-angiopoietin-1-tie2-pathway
#6
Guo Nan Yin, Hai-Rong Jin, Min-Ji Choi, Anita Limanjaya, Kalyan Ghatak, Nguyen Nhat Minh, Jiyeon Ock, Mi-Hye Kwon, Kang-Moon Song, Heon Joo Park, Ho Min Kim, Young-Guen Kwon, Ji-Kan Ryu, Jun-Kyu Suh
Penile erection requires well-coordinated interactions between vascular and nervous system. Penile neurovascular dysfunction is a major cause of erectile dysfunction (ED) in patients with diabetes, which causes poor response to oral phosphodiesterase-5 inhibitors. Dickkopf2 (DKK2), a Wnt antagonist, is known to promote angiogenesis. Here, using DKK2-Tg mice or DKK2 protein administration, we demonstrate that overexpression of DKK2 in diabetic mice enhances penile angiogenesis and neural regeneration and restores erectile function...
March 20, 2018: Diabetes
https://www.readbyqxmd.com/read/29550465/galanin-administration-partially-restores-erectile-function-after-cavernous-nerve-injury-and-mediates-endogenous-nitrergic-nerve-outgrowth-in-vitro
#7
Emmanuel Weyne, Johanna L Hannan, Thomas Gevaert, Mohammad Ayodhia Soebadi, Hotaka Matsui, Fabio Castiglione, Koenraad van Renterghem, Dirk De Ridder, Frank Van der Aa, Trinity J Bivalacqua, Maarten Albersen
BACKGROUND: Previously, we found that the neuropeptide galanin was strongly upregulated soon after bilateral cavernous nerve injury (BCNI) and that galanin and its receptors were expressed in nitrergic erectile innervation. Galanin has been observed to exert neuroregenerative effects in dorsal root ganglion neurons, but evidence for these effects in the major pelvic ganglion (MPG) after BCNI is lacking. AIM: To evaluate the neurotropic effects of galanin receptor agonists and antagonists in vitro in nitrergic neurons and MPG and in vivo in rats after BCNI...
April 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29509578/penile-metastases-from-renal-cell-carcinoma-pre-and-postcontrast-sonographic-findings
#8
Salvatore Gitto, Marta Vaiani, Tommaso Cascella, Rodolfo Lanocita
The prostate and bladder are the most common primary cancer sites for penile metastases. Here, we describe an unusual case of metastases from renal cell carcinoma to the penis discovered 1 month after nephrectomy in a 60-year-old man. The diagnosis was achieved using B-mode and contrast-enhanced ultrasound.
March 5, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29502978/combined-transplantation-of-mesenchymal-stem-cells-and-endothelial-progenitor-cells-restores-cavernous-nerve-injury-related-erectile-dysfunction
#9
Jia-Feng Fang, Xu-Na Huang, Xiao-Yan Han, Xi Ouyang, Lei Fan, Xin Zhao, Ze-Hong Chen, Hong-Bo Wei
BACKGROUND: Whether combined transplantation of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) is more effective than transplantation of a single cell type in the restoration of erectile function is unknown. AIM: To investigate the effect of combined transplantation of MSCs and EPCs on restoration of erectile function in rats with cavernous nerve injury (CNI). METHODS: MSCs were isolated from human bone marrow and EPCs were isolated from human umbilical cord blood...
March 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29493182/the-pubovesical-complex-sparing-technique-on-laparoscopic-radical-prostatectomy
#10
Rafael Batista Rebouças, Rodrigo Campos Monteiro, João Paulo Pereira Lima, Filipe Pádua B F Almeida, Cesar Araujo Britto, Marcos Tobias-Machado, Carlo Passerotti
INTRODUCTION: Preservation of urinary continence is a great challenge in Radical Prostatectomy. In order to improve functional results, Asimakopoulos et al. (2010) described a robot-assisted surgical technique with preservation of the pubovesical complex (PVC). We present a pure laparoscopic execution. PRESENTATION: A 61-year-old male patient with a diagnosis of prostate cancer, with PSA 6.54ng/ml, DRE: T1C and Gleason 6 (3+3) 1/12 fragments. All therapeutic possibilities were discussed, including active surveillance...
March 1, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29373284/erythropoietin-to-enhance-recovery-of-erectile-function-in-men-following-radical-prostatectomy-the-erect-trial
#11
Hiten D Patel, Mohamad E Allaf
Erythropoietin receptors have been localized to human penile tissue and periprostatic neurovascular bundles. ERECT is a placebo-controlled, phase 2, randomized trial assessing the effect of erythropoietin on recovery of erectile function for men undergoing radical prostatectomy for prostate cancer.
January 17, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29344321/fixed-drug-eruption-to-supplement-containing-ginkgo-biloba-and-vinpocetine-a-case-report-and-review-of-related-cutaneous-side-effects
#12
Philip R Cohen
BACKGROUND: Fixed drug eruption is a cutaneous reaction to a systemic agent that typically presents as an annular or oval erythematous patch or blister and subsequently resolves with postinflammatory hyperpigmentation at the site. Ginkgo biloba leaf extract and vinpocetine are nutritional supplements used to enhance memory in patients with dementia and age-related memory impairment conditions such as Alzheimer's disease. PURPOSE: To describe a fixed drug eruption in a man who repeatedly developed pruritus and macular erythema on his distal penile shaft after ingesting a natural product containing Ginkgo biloba and vinpocetine...
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29327306/strengthening-the-case-for-gender-neutral-and-the-nonavalent-hpv-vaccine
#13
REVIEW
Justin M Hintze, James P O'Neill
PURPOSE: The purpose of this review is to highlight the benefits of gender-neutral and the nonavalent human papillomavirus vaccination. Human papillomavirus infection is the most commonly sexually transmitted disease and is known to cause several types of cancers, including cervical, vulvar, vaginal, penile, oropharyngeal, anal, and rectal. 5% of cancers every year are attributable to human papillomavirus infection, with cervical cancer the most common and oropharyngeal cancer estimated to surpass the incidence of cervical cancer by 2020...
April 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29325693/updates-in-the-eighth-edition-of-the-tumor-node-metastasis-staging-classification-for-urologic-cancers
#14
REVIEW
Gladell P Paner, Walter M Stadler, Donna E Hansel, Rodolfo Montironi, Daniel W Lin, Mahul B Amin
The Tumor-Node-Metastasis (TNM) classification on cancer staging, jointly developed by the American Joint Commission on Cancer (AJCC) and the Union for International Cancer Control (UICC), has been updated to its 8th edition with two contemporaneous versions published by the AJCC and UICC. While the goal of the AJCC and UICC is to have identical TNM staging systems, differences exist between these two publications including in the staging of urologic cancers. Among several new facets in the AJCC staging manual, a select few of greater import include an expanded section on imaging, presentation of levels of evidence for significant changes, and endorsement of risk assessment models that pass the AJCC quality criteria such as in prostate cancer...
April 2018: European Urology
https://www.readbyqxmd.com/read/29319007/calpain-inhibition-improves-erectile-function-in-diabetic-mice-via-upregulating-endothelial-nitric-oxide-synthase-expression-and-reducing-apoptosis
#15
Hao Li, Li-Ping Chen, Tao Wang, Shao-Gang Wang, Ji-Hong Liu
Calpain activation contributes to hyperglycemia-induced endothelial dysfunction and apoptosis. This study was designed to investigate the role of calpain inhibition in improving diabetic erectile dysfunction (ED) in mice. Thirty-eight-week-old male C57BL/6J mice were divided into three groups: (1) nondiabetic control group, (2) diabetic mice + vehicle group, and (3) diabetic mice + MDL28170 (an inhibitor of calpain) group. Type 1 diabetes was induced by intraperitoneal injection of streptozotocin at 60 mg kg-1 body weight for 5 consecutive days...
January 9, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29278308/effect-of-lysyl-oxidase-lox-on-corpus-cavernous-fibrosis-caused-by-ischaemic-priapism
#16
Liang Gao, Changjing Wu, Fudong Fu, Xuanhe You, Xue Ma, Feng Qin, Tao Li, Run Wang, Jiuhong Yuan
Penile fibrosis caused by ischemic priapism (IP) adversely affects patients' erectile function. We explored the role of lysyl oxidase (LOX) in rat and human penes after ischemic priapism (IP) to verify the effects of anti-LOX in relieving penile fibrosis and preventing erectile dysfunction caused by IP in rats. Seventy-two rats were randomly divided into six groups: control group, control + β-aminopropionitrile (BAPN) group, 9 hrs group, 9 hrs + BAPN group, 24 hrs group, and 24 hrs + BAPN group. β-aminopropionitrile (BAPN), a specific inhibitor of LOX, was administered in the drinking water...
March 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29260891/tnf-%C3%AE-antagonism-with-etanercept-enhances-penile-nos-expression-cavernosal-reactivity-and-testosterone-levels-in-aged-rats
#17
Tuğçe Demirtaş Şahin, Yusufhan Yazir, Tijen Utkan, Gulcin Gacar, Selenay Furat Rençber, Semil Selcen Gocmez
Erectile dysfunction (ED) has been reported to be associated with inflammation. This study investigated the effects of tumor necrosis factor alpha (TNF-α) inhibitor etanercept on penile neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS) expressions, testosterone concentrations, neurogenic and endothelium-dependent relaxations of corpus cavernosum (CC), and circulating and cavernosal levels of inflammatory markers in aged rats. Animals were separated into control, aged, and etanercept-treated aged groups...
February 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29259207/dickkopf2-rescues-erectile-function-by-enhancing-penile-neurovascular-regeneration-in-a-mouse-model-of-cavernous-nerve-injury
#18
Kalyan Ghatak, Guo Nan Yin, Min-Ji Choi, Anita Limanjaya, Nguyen Nhat Minh, Jiyeon Ock, Kang-Moon Song, Dong Hyuk Kang, Young-Guen Kwon, Ho Min Kim, Ji-Kan Ryu, Jun-Kyu Suh
Penile erection is a neurovascular event and neurologic or vascular disturbances are major causes of erectile dysfunction (ED). Radical prostatectomy for prostate cancer not only induces cavernous nerve injury (CNI) but also results in cavernous angiopathy, which is responsible for poor responsiveness to oral phosphodiesterase-5 inhibitors. Dickkopf2 (DKK2) is known as a Wnt signaling antagonist and is reported to promote mature and stable blood vessel formation. Here, we demonstrated in CNI mice that overexpression of DKK2 by administering DKK2 protein or by using DKK2-Tg mice successfully restored erectile function: this recovery was accompanied by enhanced neural regeneration through the secretion of neurotrophic factors, and restoration of cavernous endothelial cell and pericyte content...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29241310/indocyanine-green-fluorescence-guided-sentinel-lymph-node-identification-in-urologic-cancers-a-systematic-review-and-meta-analysis
#19
Fouad Aoun, Simone Albisinni, Marc Zanaty, Toufic Hassan, Gunter Janetschek, Roland van Velthoven
INTRODUCTION: To date, bilateral pelvic lymph node dissection (PLND) represents the most accurate and reliable staging procedure for the detection of lymph node invasion in prostate cancer and bladder cancer. However, the procedure is not devoid of complications. In this field, Indocyanine green fluorescence-guided sentinel lymph node (SLN) identification is an emerging and promising technique, as accurate staging of urologic cancer could be enhanced by a thorough evaluation of the sentinel lymph nodes...
December 14, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29238658/non-pharmacological-and-non-surgical-strategies-to-promote-sexual-recovery-for-men-with-erectile-dysfunction
#20
REVIEW
Richard Wassersug, Erik Wibowo
Erectile dysfunction (ED), the most commonly reported sexual problem for men, reduces the quality of life for both patients and their partners. Even when physiologically effective, long-term adherence to ED treatments is poor. We review here the implication of having patients' partners involved in ED treatment, starting with treatment selection. We suggest that having partners engaged from the outset may promote an erotic association of the treatment with the partner, i.e., conceptually linking the aid to the sexual pleasure that the partner provides...
November 2017: Translational Andrology and Urology
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