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https://www.readbyqxmd.com/read/28382926/aldosterone-induces-inflammatory-cytokines-in-penile-corpus-cavernosum-by-activating-the-nf-%C3%AE%C2%BAb-pathway
#1
Fei Wu, Zu-Quan Xiong, Shan-Hua Mao, Ji-Meng Hu, Jian-Qing Wang, Hao-Wen Jiang, Qiang Ding
Emerging evidence indicates that aldosterone and mineralocorticoid receptors (MRs) are associated with the pathogenesis of erectile dysfunction. However, the molecular mechanisms remain largely unknown. In this study, freshly isolated penile corpus cavernosum tissue from rats was treated with aldosterone, with or without MRs inhibitors. Nuclear factor (NF)-kappa B (NF-κB) activity was evaluated by real-time quantitative PCR, luciferase assay, and immunoblot. The results demonstrated that mRNA levels of the NF-κB target genes, including inhibitor of NF-κB alpha (IκB-α), NF-κB1, tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6), were higher after aldosterone treatment...
April 4, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28316936/granulomatous-inflammation-of-the-penis-and-scrotum-following-application-of-topical-cream
#2
Amir Ishaq Khan, Akanksha Mehta, Aarti Sekhar, Carla L Ellis
Granulomas are collections of histiocytes that develop as an inflammatory response to bacterial and fungal infections, as well as foreign substances. We discuss here the case of a 49-year-old male who presented with a penile and scrotal mass with granulomatous inflammation, after application of a topical cream for enhancement of erectile function. While granuloma formation can often be seen with penile injections, this case presents the rare development of a foreign body granuloma after topical cream application on the penis and scrotum...
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28280315/collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-patient-selection-and-perspectives
#3
REVIEW
Paige K Kuhlmann, Kenneth J DeLay, James Anaissie, Wayne Jg Hellstrom, Faysal A Yafi
The safety and efficacy of the use of collagenase Clostridium histolyticum (CCH) for the treatment of Peyronie's disease has been confirmed over the past several years. However, identification of the ideal patient population for use of this treatment is not well established. Multiple studies have attempted to delineate various patient-specific factors that may predict response to treatment with CCH, with the intent of enhancing patient selection. To date, these include baseline curvature severity, duration of disease, disease phase at presentation, plaque calcification, baseline erectile function, plaque size, age, comorbid diabetes, previous penile trauma, responsiveness to first treatment cycle, baseline penile shortening or pain, prior treatment with intralesional injection, compliance with plaque modeling, and atypical curvature...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28258955/inhibition-of-cyclic-gmp-export-by-multidrug-resistance-protein-4-a-new-strategy-to-treat-erectile-dysfunction
#4
Charlotte Boydens, Bart Pauwels, Laura Vanden Daele, Johan Van de Voorde
BACKGROUND: Intracellular cyclic guanosine monophosphate (cGMP) concentrations are regulated by degradation enzymes (phosphodiesterases) and by active transport across the plasma membrane by multidrug resistance proteins (MRPs) 4 and 5. AIM: To evaluate the functional effect of MRP-4 inhibition and the role of MRP-4-mediated cGMP export in mouse corpora cavernosa. METHODS: Isometric tension of mouse corpora cavernosa was measured after cumulative addition of MK-571, an inhibitor of MRP-4, or sildenafil, a phosphodiesterase type 5 inhibitor...
April 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28242178/biofilm-and-infectious-agents-present-at-the-time-of-penile-prosthesis-revision-surgery-times-are-a-changing
#5
REVIEW
Lauren E Dawn, Gerard D Henry, Gary K Tan, Steven K Wilson
INTRODUCTION: Although infection rates have decreased with the use of antibiotic-coated implants and other enhancements, the risk of infection is still considered a serious concern in penile implant revision surgeries. AIM: To review the literature for advances made in inflatable penile prosthesis (IPP) revision surgery and organisms found at the time of revision, the significance of biofilm in prosthetic infection, and the bacteriology of infection. METHODS: PubMed was reviewed for articles spanning the past three decades that discussed micro-organisms and biofilm in relation to penile implant revision surgery...
February 24, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28238678/penile-lengthening-girth-and-size-preservation-at-the-time-of-penile-prosthesis-insertion
#6
REVIEW
Henry Tran, Robert Goldfarb, Anika Ackerman, Robert J Valenzuela
INTRODUCTION: Penile prosthetic devices are the gold standard treatment of medication-refractory erectile dysfunction. Inflatable penile prosthetic (IPP) devices have been available and used for more than four decades. Oftentimes, medical conditions causing erectile dysfunction also cause penile shortening, causing decreased patient quality of life. AIM: To identify and review all available penile lengthening procedures that can be performed at time of IPP insertion...
February 23, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28215172/the-phosphodiesterase-5-inhibitors-pde-5i-for-erectile-dysfunction-ed-a-therapeutic-challenge-for-psychiatrists
#7
Chong Siew Koon, Hatta Sidi, Jaya Kumar, Srijit Das, Ong Wan Xi, Muhammad Hizri Hatta, Cesar Alfonso
Erectile function (EF) is a prerequisite for satisfactory sexual intercourse (SI) and central to male sexual functioning. Satisfactory SI eventually leads to orgasm - a biopsychophysiological state of euphoria - leading to a sense of bliss, enjoyment and positive mental well being. For a psychiatrist, treating ED is self-propelled to harmonize these pleasurable experiences alongside with encouragement of physical wellness and sensuality. Hence, the role of PDE-5i is pivotal in the context of treating ED constitutes a therapeutic challenge...
February 15, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28161078/erectile-dysfunction-in-heme-deficient-nitric-oxide-unresponsive-soluble-guanylate-cyclase-knock-in-mice
#8
Kelly Decaluwé, Bart Pauwels, Charlotte Boydens, Robrecht Thoonen, Emmanuel S Buys, Peter Brouckaert, Johan Van de Voorde
INTRODUCTION: The nitric oxide (NO), soluble guanylate cyclase (sGC), and cyclic guanosine monophosphate (cGMP) pathway is the leading pathway in penile erection. AIM: To assess erectile function in a mouse model in which sGC is deficient in heme (apo-sGC) and unresponsive to NO. METHODS: Mutant mice (sGCβ1(ki/ki)) that express an sGC enzyme that retains basal activity but fails to respond to NO because of heme deficiency (apo-sGC) were used...
February 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28088045/uhplc-ms-ms-method-for-the-quantitation-of-penicillin-g-and-metabolites-in-citrus-fruit-using-internal-standards
#9
Daniele Canzani, Kevin Hsieh, Matthew Standland, Walter Hammack, Fadi Aldeek
Penicillin G has been applied to citrus trees as a potential treatment in the fight against Huanglongbing (HLB). Here, we have developed and validated a method to identify and quantitate penicillin G and two of its metabolites, penillic acid and penilloic acid, in citrus fruit using ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). This method improves upon a previous method by incorporating isotopically labeled internal standards, namely, penillic acid-D5, and penilloic acid-D5...
February 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28073192/the-use-of-autologous-platelet-rich-plasma-gel-in-bulbar-and-penile-buccal-mucosa-urethroplasty-preliminary-report-of-our-first-series
#10
Marcello Scarcia, Francesco Paolo Maselli, Giuseppe Cardo, Giuseppe Mario Ludovico
OBJECTIVE: The Buccal Mucosa (BM) UrethroPlasty (UP) is one of the preferred treatments for long or compli-cated urethral strictures. We propose the use of autologous Platelet Rich Plasma gel (aPRPg) in order to enhance to vascularization of BM graft and reduce the fibrous spongy. We report the outcome of our ten cases of bulbar and penile UP and the safety of this technique. Materials and metods: Ten patients underwent to BM UP with use of aPRP gel. Median age was 46. Stricture etiology was idiopathic, failed hypospadias and flogistic...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/27931509/transplantation-of-human-urine-derived-stem-cells-transfected-with-pigment-epithelium-derived-factor-to-protect-erectile-function-in-a-rat-model-of-cavernous-nerve-injury
#11
Qiyun Yang, Xin Chen, Tao Zheng, Dayu Han, Heng Zhang, Yanan Shi, Jun Bian, Xiangzhou Sun, Kai Xia, Xiaoyan Liang, Guihua Liu, Yuanyuan Zhang, Chunhua Deng
The aim of this study was to investigate whether intracavernous injection of urine-derived stem cells (USCs) or USCs genetically modified with pigment epithelium-derived factor (PEDF) could protect the erectile function and cavernous structure in a bilateral cavernous nerve injury-induced erectile dysfunction (CNIED) rat model. USCs were cultured from the urine of six healthy male donors. Seventy-five rats were randomly divided into five groups (n=15 per group): sham, bilateral cavernous nerve (CN) crush injury (BCNI), USC, USCGFP+, and USCGFP/PEDF+ groups...
November 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27879305/partial-segmental-thrombosis-of-the-corpus-cavernosum-presenting-with-perineal-pain
#12
Michelle Christodoulidou, Arie Parnham, Navin Ramachandran, Asif Muneer
We describe the case of a man aged 43 years who presented with a 2-week history of a palpable lump in the right proximal penile shaft. This was preceded by a 6-month history of perineal pain, accompanied by erectile dysfunction. An urgent MRI scan of his penis identified a thrombus within the right crus and corpus of the penis. His thrombophilia screen was normal. The patient was started on oral anticoagulation and a phosphodiesterase inhibitor (PDE-5i) to prevent thrombus progression and maintain erectile function...
November 22, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27871962/penile-implant-review-of-a-no-touch-technique
#13
REVIEW
J Francois Eid
INTRODUCTION: Over 25% of the more than 725,000 cases of nosocomial infection in the United States are related to an implantable device. Despite the standard typical strategies available, infection rates for breast implants, cerebrospinal shunts, and penile implants remain unacceptably high. This paper will review use of a "no-touch" technique in varied surgical procedures from orthopedic fracture repair, cerebrospinal fluid shunt placement, and breast reconstruction/augmentation to penile prosthesis implantation...
July 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27855594/when-chems-meet-sex-a-rising-phenomenon-called-chemsex
#14
Raffaele Giorgetti, Adriano Tagliabracci, Fabrizio Schifano, Simona Zaami, Enrico Marinelli, Francesco Paolo Busardò
BACKGROUND: The term "chemsex" was coined to indicate the voluntary intake of psychoactive and non psychoactive drugs in the context of recreational settings to facilitate and/or to enhance sexual intercourses mostly among men who have sex with other men (MSM). OBJECTIVE: The authors aimed to review the mechanisms of action, the toxicity and the pattern of use and abuse of substances involved in "chemsex" practice together with the sociocultural background underlying it and the health-related consequences that they may have...
November 17, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27822104/the-danish-national-penile-cancer-quality-database
#15
REVIEW
Jakob Kristian Jakobsen, Buket Öztürk, Mette Søgaard
AIM OF DATABASE: The Danish National Penile Cancer Quality database (DaPeCa-data) aims to improve the quality of cancer care and monitor the diagnosis, staging, and treatment of all incident penile cancer cases in Denmark. The aim is to assure referral practice, guideline adherence, and treatment and development of the database in order to enhance research opportunities and increase knowledge and survival outcomes of penile cancer. STUDY POPULATION: The DaPeCa-data registers all patients with newly diagnosed invasive squamous cell carcinoma of the penis in Denmark since June 2011...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27689159/investigation-of-penile-conditions-by-ultrasound-and-contrast-enhanced-ultrasound-presentation-of-three-clinical-cases
#16
J F Topsøe, D Dencker
No abstract text is available yet for this article.
November 2015: Ultrasound International Open
https://www.readbyqxmd.com/read/27650039/propping-up-pharma-s-natural-neoliberal-phallic-man-pharmaceutical-representations-of-the-ideal-sexuopharmaceutical-user
#17
Maria Gurevich, Usra Leedham, Amy Brown-Bowers, Nicole Cormier, Zara Mercer
Contemporary social theorists emphasise the cultural quest for authenticity under conditions of increasing artificiality. Within this context, the body is commonly treated as an 'unfinished' surface requiring ongoing transformation to fulfil identity obligations. In this paper, we examine one such identity authentication project in the form of marketing of men's sexuopharmaceuticals. We use online pharmaceutical advertising for four approved sexuopharmaceuticals (Viagra, Cialis, STAXYN and Stendra) to describe the ideal neoliberal consumer...
September 21, 2016: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/27624510/phosphodiesterase-5-inhibitor-use-an-under-reported-cause-of%C3%A2-profuse-nasal-bleeding
#18
Petros V Vlastarakos, Thomas P Nikolopoulos
BACKGROUND: Phosphodiesterase-5 (PDE-5) inhibitors enhance penile erection and have gained popularity not only for erectile dysfunction, but also in recreational settings. Nevertheless, adverse effects have been associated with their use, with nasal bleeding among them. PDE-5 inhibitor action is materialized through the inhibition of the cyclic guanosine monophosphate (cGMP) enzyme. cGMP is present at several sites of the human body in addition to the corpus cavernosum, leading to the adverse effects associated with its nonselective inhibition...
November 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27593920/kelly-procedure-for-male-primary-epispadias
#19
Pankaj Mishra, Simon Rajendran, Maria Asimakidou, Imran Mushtaq
INTRODUCTION: Primary epispadias is a rare congenital malformation involving the urogenital system. In patients with epispadias, bladder closure enhances bladder growth and continence. METHODS: Several steps were carried out to bring the bladder neck to the midline and allow tension-free bladder neck reconstruction and recreation of the natural angulation of urethra. The urethral plate and penile shaft were dissected and the corpora cavernosa separated, and then the bladder neck repair was performed...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27557611/anti-inflammatory-and-anti-fibrotic-effects-of-annexin1-on-erectile-function-after-cavernous-nerve-injury-in-rats
#20
F N Facio, M F Facio, L F Spessoto, D Pessutti, L O Reis, S G Campos, S Taboga
The aim of this study was to investigate the effect of the anti-inflammatory and anti-fibrotic actions of ANX1 on erectile function (EF). Forty-eight male Wistar rats were randomly distributed into four equal groups: one group (sham operation-control) and three groups (bilateral cavernous nerve (CN) crush injury). Crush injury groups were treated prior to injury with an intravascular injection of either ANX1 (50 or 100 μg kg(-1)) or vehicle. EF was assessed by CN electrical stimulation at 2 and 7 days after CN injury with histomorphometric and immunohistochemical analysis...
November 2016: International Journal of Impotence Research
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